#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P49593	uniprotkb:Q9UK73	intact:EBI-719945|uniprotkb:Q96PM2|uniprotkb:A8K6G3|uniprotkb:B7Z2C3|ensembl:ENSP00000263212	intact:EBI-310482|uniprotkb:O43146|ensembl:ENSP00000307298	psi-mi:ppm1f_human(display_long)|uniprotkb:"Ca(2+)/calmodulin-dependent protein kinase phosphatase"(gene name synonym)|uniprotkb:Partner of PIX 2(gene name synonym)|uniprotkb:PPM1F(gene name)|psi-mi:PPM1F(display_short)|uniprotkb:KIAA0015(gene name synonym)|uniprotkb:POPX2(gene name synonym)|uniprotkb:Protein fem-2 homolog(gene name synonym)	psi-mi:fem1b_human(display_long)|uniprotkb:FEM1B(gene name)|psi-mi:FEM1B(display_short)|uniprotkb:KIAA0396(gene name synonym)|uniprotkb:F1AA(gene name synonym)|uniprotkb:FEM1-beta(gene name synonym)|uniprotkb:Fem-1-like death receptor-binding protein alpha(gene name synonym)|uniprotkb:Fem-1-like in apoptotic pathway protein alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tan et al. (2001)	pubmed:11559703|mint:MINT-8215466|doi:10.1074/jbc.M105880200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7975025|mint:MINT-8215474	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055449.1|ensembl:ENSG00000100034(gene)|ensembl:ENST00000263212(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035690"|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903827"|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000222(Protein phosphatase 2C,  manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|mint:P49593|reactome:R-HSA-9617324|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|mint:MINT-8215476(identity)	refseq:NP_056137.1|ensembl:ENSG00000169018(gene)|ensembl:ENST00000306917(transcript)|go:"GO:0005123"(death receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051438"(regulation of ubiquitin-protein transferase activity)|go:"GO:0060442"(branching involved in prostate gland morphogenesis)|go:"GO:0060743"(epithelial cell maturation involved in prostate gland development)|go:"GO:0140627"(ubiquitin-dependent protein catabolic process via the C-end degron rule pathway)|go:"GO:1902041"(regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:6LBF|rcsb pdb:7CNG|rcsb pdb:7EL6|reactome:R-HSA-8951664|go:"GO:2000001"(regulation of DNA damage checkpoint)|dip:DIP-31663N|mint:MINT-8215478(identity)	-	-	-	figure legend:f5b|comment:homomint|comment:mint|partial coverage:partial coverage	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/13	2014/10/16	rogid:G2Zr0KQjJ8rebVMjL+Wf+OuY6rU9606	rogid:ODOxw01NrJ8fUJv2XopsdTYtAr49606	intact-crc:CD46612E376D5512|rigid:r4ZEikh1TlQGSr+QIeZFHt0n8iw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UK73	uniprotkb:P49593	intact:EBI-310482|uniprotkb:O43146|ensembl:ENSP00000307298	intact:EBI-719945|uniprotkb:Q96PM2|uniprotkb:A8K6G3|uniprotkb:B7Z2C3|ensembl:ENSP00000263212	psi-mi:fem1b_human(display_long)|uniprotkb:FEM1B(gene name)|psi-mi:FEM1B(display_short)|uniprotkb:KIAA0396(gene name synonym)|uniprotkb:F1AA(gene name synonym)|uniprotkb:FEM1-beta(gene name synonym)|uniprotkb:Fem-1-like death receptor-binding protein alpha(gene name synonym)|uniprotkb:Fem-1-like in apoptotic pathway protein alpha(gene name synonym)	psi-mi:ppm1f_human(display_long)|uniprotkb:"Ca(2+)/calmodulin-dependent protein kinase phosphatase"(gene name synonym)|uniprotkb:Partner of PIX 2(gene name synonym)|uniprotkb:PPM1F(gene name)|psi-mi:PPM1F(display_short)|uniprotkb:KIAA0015(gene name synonym)|uniprotkb:POPX2(gene name synonym)|uniprotkb:Protein fem-2 homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tan et al. (2001)	pubmed:11559703|mint:MINT-8215466|doi:10.1074/jbc.M105880200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7975096|mint:MINT-8215483	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056137.1|ensembl:ENSG00000169018(gene)|ensembl:ENST00000306917(transcript)|go:"GO:0005123"(death receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051438"(regulation of ubiquitin-protein transferase activity)|go:"GO:0060442"(branching involved in prostate gland morphogenesis)|go:"GO:0060743"(epithelial cell maturation involved in prostate gland development)|go:"GO:0140627"(ubiquitin-dependent protein catabolic process via the C-end degron rule pathway)|go:"GO:1902041"(regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:6LBF|rcsb pdb:7CNG|rcsb pdb:7EL6|reactome:R-HSA-8951664|go:"GO:2000001"(regulation of DNA damage checkpoint)|dip:DIP-31663N|mint:MINT-8215486(identity)	refseq:NP_055449.1|ensembl:ENSG00000100034(gene)|ensembl:ENST00000263212(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035690"|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903827"|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000222(Protein phosphatase 2C,  manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|mint:P49593|reactome:R-HSA-9617324|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|mint:MINT-8215485(identity)	-	-	-	figure legend:f5a|comment:homomint|comment:mint|partial coverage:partial coverage	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2011/10/13	2014/10/16	rogid:ODOxw01NrJ8fUJv2XopsdTYtAr49606	rogid:G2Zr0KQjJ8rebVMjL+Wf+OuY6rU9606	intact-crc:34050CBFA193E72A|rigid:r4ZEikh1TlQGSr+QIeZFHt0n8iw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UQM7	uniprotkb:P49593	intact:EBI-1383687|uniprotkb:Q9UL21|uniprotkb:Q9Y2H4|uniprotkb:Q9Y352|ensembl:ENSP00000261793|ensembl:ENSP00000500642	intact:EBI-719945|uniprotkb:Q96PM2|uniprotkb:A8K6G3|uniprotkb:B7Z2C3|ensembl:ENSP00000263212	psi-mi:kcc2a_human(display_long)|uniprotkb:CAMK2A(gene name)|psi-mi:CAMK2A(display_short)|uniprotkb:CAMKA(gene name synonym)|uniprotkb:KIAA0968(gene name synonym)	psi-mi:ppm1f_human(display_long)|uniprotkb:"Ca(2+)/calmodulin-dependent protein kinase phosphatase"(gene name synonym)|uniprotkb:Partner of PIX 2(gene name synonym)|uniprotkb:PPM1F(gene name)|psi-mi:PPM1F(display_short)|uniprotkb:KIAA0015(gene name synonym)|uniprotkb:POPX2(gene name synonym)|uniprotkb:Protein fem-2 homolog(gene name synonym)	psi-mi:"MI:0434"(phosphatase assay)	Tan et al. (2001)	pubmed:11559703|mint:MINT-8215466|doi:10.1074/jbc.M105880200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0203"(dephosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7975161|mint:MINT-8215492	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_741960.1|ensembl:ENSG00000070808(gene)|ensembl:ENST00000348628(transcript)|ensembl:ENST00000672479(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060996"(dendritic spine development)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|go:"GO:2000124"(regulation of endocannabinoid signaling pathway)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:Q9UQM7|rcsb pdb:2VZ6|rcsb pdb:3SOA|rcsb pdb:5IG3|rcsb pdb:6OF8|rcsb pdb:6VZK|rcsb pdb:6W4O|rcsb pdb:6W4P|rcsb pdb:6X5G|rcsb pdb:6X5Q|rcsb pdb:6X8V|rcsb pdb:6XBP|rcsb pdb:6XBX|rcsb pdb:6XDL|rcsb pdb:6XDU|rcsb pdb:6XF0|rcsb pdb:6XOE|rcsb pdb:7KL0|rcsb pdb:7KL1|rcsb pdb:7KL2|rcsb pdb:7KL4|reactome:R-HSA-111932|reactome:R-HSA-3371571|reactome:R-HSA-399719|reactome:R-HSA-4086398|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-6802946|go:"GO:0016301"(kinase activity)|reactome:R-HSA-6802952|reactome:R-HSA-877300|reactome:R-HSA-9022692|reactome:R-HSA-936837|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-6802955|dip:DIP-39705N|mint:MINT-8215495(identity)	refseq:NP_055449.1|ensembl:ENSG00000100034(gene)|ensembl:ENST00000263212(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035690"|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903827"|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000222(Protein phosphatase 2C,  manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|mint:P49593|reactome:R-HSA-9617324|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|mint:MINT-8215494(identity)	-	comment:"Resulting Phenotypic qualities (properties)[PATO]: PATO:0002263 (dephosphorylated)"	-	figure legend:f3|comment:homomint|comment:mint|partial coverage:partial coverage	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/13	2014/10/16	rogid:7uql+9kLfmK9drY5L0oKOH7zPk49606	rogid:G2Zr0KQjJ8rebVMjL+Wf+OuY6rU9606	intact-crc:C71D1E21AD700F2B|rigid:rFie7KY6BSe9D6Dy3R5t26Aq+Ms	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9WVR7	uniprotkb:Q9UQM7	intact:EBI-7975218|intact:MINT-4621280|ensembl:ENSRNOP00000002530	intact:EBI-1383687|uniprotkb:Q9UL21|uniprotkb:Q9Y2H4|uniprotkb:Q9Y352|ensembl:ENSP00000261793|ensembl:ENSP00000500642	psi-mi:ppm1f_rat(display_long)|uniprotkb:Ppm1f(gene name)|psi-mi:Ppm1f(display_short)|uniprotkb:Popx2(gene name synonym)|uniprotkb:"Ca(2+)/calmodulin-dependent protein kinase phosphatase"(gene name synonym)|uniprotkb:Partner of PIX 2(gene name synonym)	psi-mi:kcc2a_human(display_long)|uniprotkb:CAMK2A(gene name)|psi-mi:CAMK2A(display_short)|uniprotkb:CAMKA(gene name synonym)|uniprotkb:KIAA0968(gene name synonym)	psi-mi:"MI:0434"(phosphatase assay)	Tan et al. (2001)	pubmed:11559703|mint:MINT-8215466|doi:10.1074/jbc.M105880200	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0203"(dephosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7975254|mint:MINT-8215509	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_786931.1|rgd:631363|refseq:XP_006248736.1|ensembl:ENSRNOG00000037909(gene)|ensembl:ENSRNOT00000002530(transcript)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0035690"|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903827"|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000222(Protein phosphatase 2C,  manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|mint:MINT-8215512(identity)	refseq:NP_741960.1|ensembl:ENSG00000070808(gene)|ensembl:ENST00000348628(transcript)|ensembl:ENST00000672479(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060996"(dendritic spine development)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|go:"GO:2000124"(regulation of endocannabinoid signaling pathway)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:Q9UQM7|rcsb pdb:2VZ6|rcsb pdb:3SOA|rcsb pdb:5IG3|rcsb pdb:6OF8|rcsb pdb:6VZK|rcsb pdb:6W4O|rcsb pdb:6W4P|rcsb pdb:6X5G|rcsb pdb:6X5Q|rcsb pdb:6X8V|rcsb pdb:6XBP|rcsb pdb:6XBX|rcsb pdb:6XDL|rcsb pdb:6XDU|rcsb pdb:6XF0|rcsb pdb:6XOE|rcsb pdb:7KL0|rcsb pdb:7KL1|rcsb pdb:7KL2|rcsb pdb:7KL4|reactome:R-HSA-111932|reactome:R-HSA-3371571|reactome:R-HSA-399719|reactome:R-HSA-4086398|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-6802946|go:"GO:0016301"(kinase activity)|reactome:R-HSA-6802952|reactome:R-HSA-877300|reactome:R-HSA-9022692|reactome:R-HSA-936837|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-6802955|dip:DIP-39705N|mint:MINT-8215511(identity)	-	comment:mint|function:Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis	comment:"Resulting Phenotypic qualities (properties)[PATO]: PATO:0002263 (dephosphorylated)"	figure legend:f3|comment:homomint|comment:mint|partial coverage:partial coverage	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/13	2014/10/16	rogid:/9gCSuPRiD84oVXWuJbwJytvRgo10116	rogid:7uql+9kLfmK9drY5L0oKOH7zPk49606	intact-crc:AAA647761E544DB9|rigid:QbquL6VW8d3CCJeRUvvg9c6COhc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49594	uniprotkb:Q9UQM7	intact:EBI-1998402|ensemblmetazoa:T19C3.8.1|ensemblmetazoa:T19C3.8.2	intact:EBI-1383687|uniprotkb:Q9UL21|uniprotkb:Q9Y2H4|uniprotkb:Q9Y352|ensembl:ENSP00000261793|ensembl:ENSP00000500642	psi-mi:fem2_caeel(display_long)|uniprotkb:"Ca(2+)/calmodulin-dependent protein kinase phosphatase"(gene name synonym)|uniprotkb:fem-2(gene name)|psi-mi:fem-2(display_short)|uniprotkb:Sex-determining protein fem-2(gene name synonym)|uniprotkb:Feminization of XX and XO animals protein 2(gene name synonym)|uniprotkb:T19C3.8(orf name)	psi-mi:kcc2a_human(display_long)|uniprotkb:CAMK2A(gene name)|psi-mi:CAMK2A(display_short)|uniprotkb:CAMKA(gene name synonym)|uniprotkb:KIAA0968(gene name synonym)	psi-mi:"MI:0434"(phosphatase assay)	Tan et al. (2001)	pubmed:11559703|mint:MINT-8215466|doi:10.1074/jbc.M105880200	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0203"(dephosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7975183|mint:MINT-8215504	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_497224.1|wormbase:T19C3.8|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR000222(Protein phosphatase 2C,  manganese/magnesium aspartate binding site)|interpro:IPR015655(Protein phosphatase 2C)|rcsb pdb:4JND|interpro:IPR036457|ensemblmetazoa:T19C3.8.1(transcript)|ensemblmetazoa:T19C3.8.2(transcript)|ensemblmetazoa:WBGene00001412(gene)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0030154"(cell differentiation)|go:"GO:0030238"(male sex determination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042006"(masculinization of hermaphroditic germ-line)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045138"(nematode male tail tip morphogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|mint:MINT-8215506(identity)	refseq:NP_741960.1|ensembl:ENSG00000070808(gene)|ensembl:ENST00000348628(transcript)|ensembl:ENST00000672479(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060996"(dendritic spine development)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|go:"GO:2000124"(regulation of endocannabinoid signaling pathway)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:Q9UQM7|rcsb pdb:2VZ6|rcsb pdb:3SOA|rcsb pdb:5IG3|rcsb pdb:6OF8|rcsb pdb:6VZK|rcsb pdb:6W4O|rcsb pdb:6W4P|rcsb pdb:6X5G|rcsb pdb:6X5Q|rcsb pdb:6X8V|rcsb pdb:6XBP|rcsb pdb:6XBX|rcsb pdb:6XDL|rcsb pdb:6XDU|rcsb pdb:6XF0|rcsb pdb:6XOE|rcsb pdb:7KL0|rcsb pdb:7KL1|rcsb pdb:7KL2|rcsb pdb:7KL4|reactome:R-HSA-111932|reactome:R-HSA-3371571|reactome:R-HSA-399719|reactome:R-HSA-4086398|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-6802946|go:"GO:0016301"(kinase activity)|reactome:R-HSA-6802952|reactome:R-HSA-877300|reactome:R-HSA-9022692|reactome:R-HSA-936837|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-6802955|dip:DIP-39705N|mint:MINT-8215507(identity)	-	-	comment:"Resulting Phenotypic qualities (properties)[PATO]: PATO:0002263 (dephosphorylated)"	figure legend:f3|comment:mint|partial coverage:partial coverage	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/13	2014/10/16	rogid:R70Rc3Xej/Sikn9mEg+MTaYT4eE6239	rogid:7uql+9kLfmK9drY5L0oKOH7zPk49606	intact-crc:1E469A119F7C1253|rigid:iea9NPk26QL9dCj5H2x6JMFsbcc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)