#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P15379 uniprotkb:P41241 intact:EBI-7565891|intact:EBI-15579519|uniprotkb:Q62063|uniprotkb:Q62061|uniprotkb:Q05732|intact:UNK-5943644|uniprotkb:Q9QYX8|uniprotkb:Q62408|uniprotkb:Q99J14|uniprotkb:Q64296|uniprotkb:Q61395|uniprotkb:Q62060|uniprotkb:Q62062|uniprotkb:Q62409 intact:EBI-2553183|uniprotkb:Q80WU4|uniprotkb:Q8VCW1|ensembl:ENSMUSP00000034863|ensembl:ENSMUSP00000150590|ensembl:ENSMUSP00000150984|uniprotkb:Q03143 psi-mi:cd44_mouse(display_long)|uniprotkb:Phagocytic glycoprotein I(gene name synonym)|uniprotkb:Cd44(gene name)|psi-mi:Cd44(display_short)|uniprotkb:Ly-24(gene name synonym)|uniprotkb:Phagocytic glycoprotein 1(gene name synonym)|uniprotkb:HUTCH-I(gene name synonym)|uniprotkb:Extracellular matrix receptor III(gene name synonym)|uniprotkb:GP90 lymphocyte homing/adhesion receptor(gene name synonym)|uniprotkb:Hermes antigen(gene name synonym)|uniprotkb:Hyaluronate receptor(gene name synonym)|uniprotkb:Lymphocyte antigen 24(gene name synonym) psi-mi:csk_mouse(display_long)|uniprotkb:Csk(gene name)|psi-mi:Csk(display_short)|uniprotkb:C-Src kinase(gene name synonym)|uniprotkb:Protein-tyrosine kinase MPK-2(gene name synonym)|uniprotkb:p50CSK(gene name synonym) psi-mi:"MI:0029"(cosedimentation through density gradient) Li et al. (2001) pubmed:11369760|mint:MINT-8212425|doi:10.1074/jbc.M100158200 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7847705|mint:MINT-8212434 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001171257.1|refseq:NP_001034240.1|refseq:NP_001171258.1|refseq:NP_033981.2|refseq:NP_001171256.1|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0002246"(wound healing involved in inflammatory response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0031175"(neuron projection development)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060442"(branching involved in prostate gland morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070487"(monocyte aggregation)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000392"(regulation of lamellipodium morphogenesis)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|interpro:IPR000538(Link)|interpro:IPR001231(CD44 antigen)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR043210|rcsb pdb:2JCP|rcsb pdb:2JCQ|rcsb pdb:5BZJ|rcsb pdb:2JCR|rcsb pdb:5BZK|rcsb pdb:5BZL|rcsb pdb:5BZM|rcsb pdb:5BZN|rcsb pdb:5BZO|rcsb pdb:2ZPY|rcsb pdb:5BZP|rcsb pdb:5BZQ|rcsb pdb:5BZR|rcsb pdb:5BZS|rcsb pdb:5BZT|rcsb pdb:4MRD|rcsb pdb:4MRE|rcsb pdb:4MRF|rcsb pdb:4MRG|rcsb pdb:4MRH|rcsb pdb:4NP2|rcsb pdb:4NP3|rcsb pdb:5BZC|rcsb pdb:5BZE|rcsb pdb:5BZF|rcsb pdb:5BZG|rcsb pdb:5BZH|rcsb pdb:5BZI|dip:DIP-29095N|reactome:R-MMU-1474228|reactome:R-MMU-202733|reactome:R-MMU-216083|reactome:R-MMU-2160916|reactome:R-MMU-6798695|mint:MINT-8212438(identity) refseq:NP_001291690.1|go:"GO:0016740"(transferase activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005911"(cell-cell junction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048709"(oligodendrocyte differentiation)|ensembl:ENSMUSG00000032312(gene)|ensembl:ENSMUST00000034863(transcript)|ensembl:ENSMUST00000215396(transcript)|ensembl:ENSMUST00000217314(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|go:"GO:0050765"(negative regulation of phagocytosis)|interpro:IPR035027|interpro:IPR036028|interpro:IPR036860|rcsb pdb:1JEG|reactome:R-MMU-180292|reactome:R-MMU-202427|reactome:R-MMU-354192|reactome:R-MMU-389948|reactome:R-MMU-5674135|reactome:R-MMU-9013407|reactome:R-MMU-9706369|refseq:NP_031809.2|refseq:XP_006510864.1|refseq:XP_006510865.1|mint:MINT-8212436(identity) - function:Main cell surface receptor for hyaluronate. Adhesion to mucosal high endothelial venule and to types I and VI collagen. Probably involved in matrix adhesion, lymphocyte activation and lymph node homing|comment:mint - comment:homomint|comment:mint|figure legend:f5 t1|partial coverage:partial coverage taxid:10090(mouse)|taxid:10090(Mus musculus) - 2011/10/05 2018/04/06 rogid:1Rlb+aBsm9z0HJuB6Oz4Oilui1o10090 rogid:2unY4cD7qXpvYgIJ59ajuZ/FSiQ10090 intact-crc:2933908CD3B81E8C|rigid:b9P5HT7gUw2p8qNdeo5S+Xs5SRA false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P15379 uniprotkb:P06240 intact:EBI-7565891|intact:EBI-15579519|uniprotkb:Q62063|uniprotkb:Q62061|uniprotkb:Q05732|intact:UNK-5943644|uniprotkb:Q9QYX8|uniprotkb:Q62408|uniprotkb:Q99J14|uniprotkb:Q64296|uniprotkb:Q61395|uniprotkb:Q62060|uniprotkb:Q62062|uniprotkb:Q62409 intact:EBI-1401|ensembl:ENSMUSP00000066209|ensembl:ENSMUSP00000099656|uniprotkb:Q62320|uniprotkb:Q61795|uniprotkb:Q61794|uniprotkb:Q91X65 psi-mi:cd44_mouse(display_long)|uniprotkb:Phagocytic glycoprotein I(gene name synonym)|uniprotkb:Cd44(gene name)|psi-mi:Cd44(display_short)|uniprotkb:Ly-24(gene name synonym)|uniprotkb:Phagocytic glycoprotein 1(gene name synonym)|uniprotkb:HUTCH-I(gene name synonym)|uniprotkb:Extracellular matrix receptor III(gene name synonym)|uniprotkb:GP90 lymphocyte homing/adhesion receptor(gene name synonym)|uniprotkb:Hermes antigen(gene name synonym)|uniprotkb:Hyaluronate receptor(gene name synonym)|uniprotkb:Lymphocyte antigen 24(gene name synonym) psi-mi:lck_mouse(display_long)|uniprotkb:Lck(gene name)|psi-mi:Lck(display_short)|uniprotkb:Lsk-t(gene name synonym)|uniprotkb:Lymphocyte cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:p56-LCK(gene name synonym)|uniprotkb:Leukocyte C-terminal Src kinase(gene name synonym) psi-mi:"MI:0029"(cosedimentation through density gradient) Li et al. (2001) pubmed:11369760|mint:MINT-8212425|doi:10.1074/jbc.M100158200 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7847705|mint:MINT-8212434 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001171257.1|refseq:NP_001034240.1|refseq:NP_001171258.1|refseq:NP_033981.2|refseq:NP_001171256.1|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0002246"(wound healing involved in inflammatory response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0031175"(neuron projection development)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060442"(branching involved in prostate gland morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070487"(monocyte aggregation)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000392"(regulation of lamellipodium morphogenesis)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|interpro:IPR000538(Link)|interpro:IPR001231(CD44 antigen)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR043210|rcsb pdb:2JCP|rcsb pdb:2JCQ|rcsb pdb:5BZJ|rcsb pdb:2JCR|rcsb pdb:5BZK|rcsb pdb:5BZL|rcsb pdb:5BZM|rcsb pdb:5BZN|rcsb pdb:5BZO|rcsb pdb:2ZPY|rcsb pdb:5BZP|rcsb pdb:5BZQ|rcsb pdb:5BZR|rcsb pdb:5BZS|rcsb pdb:5BZT|rcsb pdb:4MRD|rcsb pdb:4MRE|rcsb pdb:4MRF|rcsb pdb:4MRG|rcsb pdb:4MRH|rcsb pdb:4NP2|rcsb pdb:4NP3|rcsb pdb:5BZC|rcsb pdb:5BZE|rcsb pdb:5BZF|rcsb pdb:5BZG|rcsb pdb:5BZH|rcsb pdb:5BZI|dip:DIP-29095N|reactome:R-MMU-1474228|reactome:R-MMU-202733|reactome:R-MMU-216083|reactome:R-MMU-2160916|reactome:R-MMU-6798695|mint:MINT-8212438(identity) ensembl:ENSMUSG00000000409(gene)|ensembl:ENSMUST00000067240(transcript)|ensembl:ENSMUST00000102596(transcript)|go:"GO:0000242"(pericentriolar material)|refseq:NP_001155905.1|refseq:NP_034823.1|refseq:XP_006502881.1|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003823"(antigen binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010038"(response to metal ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070474"(positive regulation of uterine smooth muscle contraction)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|go:"GO:1990405"(protein antigen binding)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202424|reactome:R-MMU-202427|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-389948|reactome:R-MMU-6811558|reactome:R-MMU-9013407|reactome:R-MMU-9020558|reactome:R-MMU-9706374|mint:MINT-8212437(identity) - function:Main cell surface receptor for hyaluronate. Adhesion to mucosal high endothelial venule and to types I and VI collagen. Probably involved in matrix adhesion, lymphocyte activation and lymph node homing|comment:mint - comment:homomint|comment:mint|figure legend:f5 t1|partial coverage:partial coverage taxid:10090(mouse)|taxid:10090(Mus musculus) - 2011/10/05 2018/04/06 rogid:1Rlb+aBsm9z0HJuB6Oz4Oilui1o10090 rogid:yjMU0fxTseBSR5/aEXmp2cR7Mts10090 intact-crc:2933908CD3B81E8C|rigid:b9P5HT7gUw2p8qNdeo5S+Xs5SRA false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P15379 uniprotkb:P06800 intact:EBI-7565891|intact:EBI-15579519|uniprotkb:Q62063|uniprotkb:Q62061|uniprotkb:Q05732|intact:UNK-5943644|uniprotkb:Q9QYX8|uniprotkb:Q62408|uniprotkb:Q99J14|uniprotkb:Q64296|uniprotkb:Q61395|uniprotkb:Q62060|uniprotkb:Q62062|uniprotkb:Q62409 intact:EBI-1672|uniprotkb:E9QLT5|uniprotkb:Q61812|uniprotkb:Q61813|uniprotkb:Q61814|uniprotkb:Q61815|uniprotkb:Q78EF1|ensembl:ENSMUSP00000138350|uniprotkb:S4R1S4|uniprotkb:S4R2V1 psi-mi:cd44_mouse(display_long)|uniprotkb:Phagocytic glycoprotein I(gene name synonym)|uniprotkb:Cd44(gene name)|psi-mi:Cd44(display_short)|uniprotkb:Ly-24(gene name synonym)|uniprotkb:Phagocytic glycoprotein 1(gene name synonym)|uniprotkb:HUTCH-I(gene name synonym)|uniprotkb:Extracellular matrix receptor III(gene name synonym)|uniprotkb:GP90 lymphocyte homing/adhesion receptor(gene name synonym)|uniprotkb:Hermes antigen(gene name synonym)|uniprotkb:Hyaluronate receptor(gene name synonym)|uniprotkb:Lymphocyte antigen 24(gene name synonym) psi-mi:ptprc_mouse(display_long)|uniprotkb:Ptprc(gene name)|psi-mi:Ptprc(display_short)|uniprotkb:Ly-5(gene name synonym)|uniprotkb:Lymphocyte antigen 5(gene name synonym)|uniprotkb:T200(gene name synonym)|uniprotkb:Leukocyte common antigen(gene name synonym) psi-mi:"MI:0029"(cosedimentation through density gradient) Li et al. (2001) pubmed:11369760|mint:MINT-8212425|doi:10.1074/jbc.M100158200 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7847705|mint:MINT-8212434 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001171257.1|refseq:NP_001034240.1|refseq:NP_001171258.1|refseq:NP_033981.2|refseq:NP_001171256.1|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0002246"(wound healing involved in inflammatory response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0031175"(neuron projection development)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034238"(macrophage fusion)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060442"(branching involved in prostate gland morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070487"(monocyte aggregation)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000392"(regulation of lamellipodium morphogenesis)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|interpro:IPR000538(Link)|interpro:IPR001231(CD44 antigen)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR043210|rcsb pdb:2JCP|rcsb pdb:2JCQ|rcsb pdb:5BZJ|rcsb pdb:2JCR|rcsb pdb:5BZK|rcsb pdb:5BZL|rcsb pdb:5BZM|rcsb pdb:5BZN|rcsb pdb:5BZO|rcsb pdb:2ZPY|rcsb pdb:5BZP|rcsb pdb:5BZQ|rcsb pdb:5BZR|rcsb pdb:5BZS|rcsb pdb:5BZT|rcsb pdb:4MRD|rcsb pdb:4MRE|rcsb pdb:4MRF|rcsb pdb:4MRG|rcsb pdb:4MRH|rcsb pdb:4NP2|rcsb pdb:4NP3|rcsb pdb:5BZC|rcsb pdb:5BZE|rcsb pdb:5BZF|rcsb pdb:5BZG|rcsb pdb:5BZH|rcsb pdb:5BZI|dip:DIP-29095N|reactome:R-MMU-1474228|reactome:R-MMU-202733|reactome:R-MMU-216083|reactome:R-MMU-2160916|reactome:R-MMU-6798695|mint:MINT-8212438(identity) refseq:XP_006529323.1|ensembl:ENSMUSG00000026395(gene)|ensembl:ENSMUST00000183301(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002711"(positive regulation of T cell mediated immunity)|go:"GO:0002923"(regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004725"(protein tyrosine phosphatase activity)|refseq:NP_001104786.2|refseq:XP_006529320.1|refseq:XP_006529321.1|refseq:XP_006529322.1|refseq:NP_035340.3|go:"GO:0006933"(negative regulation of cell adhesion involved in substrate-bound cell migration)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030507"(spectrin binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032059"(bleb)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0032677"(regulation of interleukin-8 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0044855"(plasma membrane raft distribution)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045121"(membrane raft)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048539"(bone marrow development)|go:"GO:0048864"(stem cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071944"(cell periphery)|go:"GO:0098857"(membrane microdomain)|go:"GO:1903615"(positive regulation of protein tyrosine phosphatase activity)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:2000473"(positive regulation of hematopoietic stem cell migration)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050857"(positive regulation of antigen receptor-mediated signaling pathway)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061097"(regulation of protein tyrosine kinase activity)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR016335(Leukocyte common antigen)|interpro:IPR024739|interpro:IPR029021|interpro:IPR036116|mint:P06800|reactome:R-MMU-202427|reactome:R-MMU-416700|reactome:R-MMU-6798695|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|mint:MINT-8212439(identity) - function:Main cell surface receptor for hyaluronate. Adhesion to mucosal high endothelial venule and to types I and VI collagen. Probably involved in matrix adhesion, lymphocyte activation and lymph node homing|comment:mint - comment:homomint|comment:mint|figure legend:f5 t1|partial coverage:partial coverage taxid:10090(mouse)|taxid:10090(Mus musculus) - 2011/10/05 2018/04/06 rogid:1Rlb+aBsm9z0HJuB6Oz4Oilui1o10090 rogid:rVsavXUDYPWKoE9O8SxF2EvjLFQ10090 intact-crc:2933908CD3B81E8C|rigid:b9P5HT7gUw2p8qNdeo5S+Xs5SRA false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)