#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P42574	uniprotkb:P07949-2	intact:EBI-524064|ensembl:ENSP00000311032|ensembl:ENSP00000428929|uniprotkb:Q96AN1|uniprotkb:Q96KP2|uniprotkb:A8K5M2|uniprotkb:D3DP53	intact:EBI-4423689|ensembl:ENSP00000344798	psi-mi:casp3_human(display_long)|uniprotkb:Apopain(gene name synonym)|uniprotkb:Cysteine protease CPP32(gene name synonym)|uniprotkb:Protein Yama(gene name synonym)|uniprotkb:SREBP cleavage activity 1(gene name synonym)|uniprotkb:CASP3(gene name)|psi-mi:CASP3(display_short)|uniprotkb:CPP32(gene name synonym)	psi-mi:p07949-2(display_long)|uniprotkb:RET9(isoform synonym)|uniprotkb:RET(gene name)|psi-mi:RET(display_short)|uniprotkb:CDHF12(gene name synonym)|uniprotkb:Cadherin family member 12(gene name synonym)|uniprotkb:Proto-oncogene c-Ret(gene name synonym)|uniprotkb:CDHR16(gene name synonym)|uniprotkb:PTC(gene name synonym)|uniprotkb:RET51(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Bordeaux et al. (2000)	pubmed:10921886|imex:IM-17200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4423698|imex:IM-17200-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0009749"(response to glucose)|go:"GO:0001554"(luteolysis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002020"(protease binding)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000164305(gene)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|ensembl:ENST00000308394(transcript)|ensembl:ENST00000523916(transcript)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007611"(learning or memory)|go:"GO:0008233"(peptidase activity)|go:"GO:0008627"(intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:0009411"(response to UV)|go:"GO:0010165"(response to X-ray)|go:"GO:0016005"(phospholipase A2 activator activity)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016485"(protein processing)|go:"GO:0021766"(hippocampus development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035094"(response to nicotine)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045165"(cell fate commitment)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061713"(anterior neural tube closure)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|rcsb pdb:1GFW|rcsb pdb:1I3O|rcsb pdb:1NME|rcsb pdb:1NMQ|rcsb pdb:1NMS|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P42574|interpro:IPR002398(Peptidase C14, caspase precursor p45)|rcsb pdb:1CP3|rcsb pdb:4QUH|rcsb pdb:4QUI|rcsb pdb:4QUD|rcsb pdb:4QUJ|rcsb pdb:4QUL|rcsb pdb:5I9B|rcsb pdb:5I9T|rcsb pdb:5IAB|rcsb pdb:5IAE|rcsb pdb:5IAG|rcsb pdb:4QUE|rcsb pdb:5IAJ|rcsb pdb:4QUG|rcsb pdb:5IAK|rcsb pdb:5IAN|rcsb pdb:5IAR|rcsb pdb:5IAS|rcsb pdb:5IBC|rcsb pdb:5IBP|rcsb pdb:5IBR|rcsb pdb:5IC4|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111465|reactome:R-HSA-111469|reactome:R-HSA-140342|reactome:R-HSA-1474228|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-211736|reactome:R-HSA-264870|reactome:R-HSA-351906|reactome:R-HSA-418889|reactome:R-HSA-449836|reactome:R-HSA-5620971|reactome:R-HSA-111464|rcsb pdb:1QX3|rcsb pdb:1RE1|rcsb pdb:1RHJ|rcsb pdb:1RHK|rcsb pdb:1RHM|rcsb pdb:1RHQ|rcsb pdb:1RHR|rcsb pdb:1RHU|rcsb pdb:2C1E|rcsb pdb:2C2K|rcsb pdb:2C2M|rcsb pdb:2C2O|rcsb pdb:2CDR|rcsb pdb:2CJX|rcsb pdb:2CJY|rcsb pdb:2CNK|rcsb pdb:2CNL|rcsb pdb:2CNN|rcsb pdb:2CNO|rcsb pdb:2DKO|rcsb pdb:2H5I|rcsb pdb:2H5J|rcsb pdb:2H65|rcsb pdb:2J30|rcsb pdb:2J31|rcsb pdb:2J32|rcsb pdb:2J33|rcsb pdb:2XYG|rcsb pdb:2XYH|rcsb pdb:2XYP|rcsb pdb:2XZD|rcsb pdb:2XZT|rcsb pdb:2Y0B|rcsb pdb:3DEH|rcsb pdb:1PAU|rcsb pdb:3DEI|rcsb pdb:3DEJ|rcsb pdb:3DEK|rcsb pdb:3EDQ|rcsb pdb:3GJQ|rcsb pdb:3GJS|rcsb pdb:3GJT|rcsb pdb:3H0E|rcsb pdb:3ITN|rcsb pdb:3KJF|rcsb pdb:3PCX|rcsb pdb:3PD0|rcsb pdb:3PD1|rcsb pdb:4DCJ|rcsb pdb:4DCO|rcsb pdb:4DCP|rcsb pdb:4EHA|rcsb pdb:4EHD|rcsb pdb:4EHF|rcsb pdb:4EHH|rcsb pdb:4EHK|rcsb pdb:4EHL|rcsb pdb:4EHN|rcsb pdb:4JJE|rcsb pdb:4JQY|rcsb pdb:4JQZ|rcsb pdb:4JR0|rcsb pdb:4PRY|rcsb pdb:4PS0|rcsb pdb:4QTX|rcsb pdb:3GJR|rcsb pdb:4QTY|rcsb pdb:4QU0|rcsb pdb:4QU5|rcsb pdb:4QU8|rcsb pdb:4QU9|rcsb pdb:4QUA|rcsb pdb:4QUB|refseq:XP_011530603.1|refseq:NP_004337.2|refseq:NP_116786.1|dip:DIP-268N	ensembl:ENST00000340058(transcript)|ensembl:ENSG00000165731(gene)|intact:EBI-2480756(isoform-parent)	go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)	-	-	figure legend:5a and 5b|comment:Mutations asp707asn and asp1017asn partially prevent the cleavage of ret and the formation of the 42 and 36 kDa fragments that result from casp3 proteolysis of the wild type.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/07	2014/10/16	rogid:o7/WP52saFha1/FD2z1rIgVLDfI9606	rogid:ogUdvBYF4rHN85J3QKd2jDBsPFA9606	intact-crc:BB0F2FE85B5358EF|rigid:M6lvaQH7DbsvVoN391+8kpIU91E	false	his tag:c-c	mutation:707-707|sufficient binding region:656-1072|35s radiolabel:?-?|mutation:1017-1017	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)