#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q63584	uniprotkb:Q63524	intact:EBI-918648|uniprotkb:Q9R0W6|ensembl:ENSRNOP00000010512	intact:EBI-918600|ensembl:ENSRNOP00000001397	psi-mi:tmeda_rat(display_long)|uniprotkb:21 kDa transmembrane-trafficking protein(gene name synonym)|uniprotkb:Transmembrane protein Tmp21(gene name synonym)|uniprotkb:Tmed10(gene name)|psi-mi:Tmed10(display_short)|uniprotkb:Tmp21(gene name synonym)|uniprotkb:p24 family protein delta-1(gene name synonym)	psi-mi:tmed2_rat(display_long)|uniprotkb:RNP21.4(gene name synonym)|uniprotkb:Tmed2(gene name)|psi-mi:Tmed2(display_short)|uniprotkb:Rnp24(gene name synonym)|uniprotkb:Membrane protein p24A(gene name synonym)|uniprotkb:p24 family protein beta-1(gene name synonym)|uniprotkb:COPI-coated vesicle membrane protein p24(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gommel et al. (1999)	pubmed:10214941|imex:IM-17269	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4404325|imex:IM-17269-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620970|refseq:NP_445919.1|ensembl:ENSRNOG00000007901(gene)|ensembl:ENSRNOT00000010512(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001822"(kidney development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006903"(vesicle targeting)|go:"GO:0007030"(Golgi organization)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0035964"(COPI-coated vesicle budding)|go:"GO:0042470"(melanosome)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043279"(response to alkaloid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0048199"(vesicle targeting, to, from or within Golgi)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0106272"(protein localization to ERGIC)|go:"GO:0106273"(cytosol to ERGIC protein transport)|go:"GO:1902003"(regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|rcsb pdb:5AZX|rcsb pdb:5AZY|reactome:R-RNO-204005|reactome:R-RNO-5694530|reactome:R-RNO-6807878|reactome:R-RNO-6811434	rgd:69243|refseq:NP_113910.1|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0008104"(protein localization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0030663"(COPI-coated vesicle membrane)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060717"(chorion development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1905069"(allantois development)|go:"GO:2000638"(regulation of SREBP signaling pathway)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|interpro:IPR036598|reactome:R-RNO-1912420|reactome:R-RNO-204005|reactome:R-RNO-5694530|reactome:R-RNO-6807878|reactome:R-RNO-6811434|ensembl:ENSRNOG00000001053(gene)|ensembl:ENSRNOT00000001397(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006903"(vesicle targeting)	go:"GO:0000139"(Golgi membrane)|go:"GO:0031410"(cytoplasmic vesicle)	-	-	figure legend:3c and d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-liver)|taxid:10116(rattus norvegicus liver)	-	2011/09/15	2014/10/16	rogid:E5kc3oLWmHd2jYmV7UgVVX1IdWo10116	rogid:AkWi3UzhfnHE9tYW4/BJzXratrk10116	intact-crc:F633C29EE55A1B4B|rigid:TBL9qZI68WabJcmAwyAkhOrUH1w	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49020	uniprotkb:G3HFR3	intact:EBI-4406065	intact:EBI-4406063	psi-mi:tmed2_crigr(display_long)|uniprotkb:TMED2(gene name)|psi-mi:TMED2(display_short)|uniprotkb:RNP24(gene name synonym)|uniprotkb:COPI-coated vesicle membrane protein p24(gene name synonym)|uniprotkb:p24 family protein beta-1(gene name synonym)	psi-mi:g3hfr3_crigr(display_long)|uniprotkb:I79_009427(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Gommel et al. (1999)	pubmed:10214941|imex:IM-17269	taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)")	taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4406074|imex:IM-17269-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR009038(GOLD)|interpro:IPR036598|interpro:IPR015720(TMP21 related)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007030"(Golgi organization)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0030663"(COPI-coated vesicle membrane)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0072659"(protein localization to plasma membrane)	interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)	-	comment:Similar to Q15363	-	figure legend:Fig. 3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2011/09/15	2014/10/16	rogid:mMYLHyWJkjhogWhIS5CkOMjIuVc10029	rogid:G+QIgGyDzNR5QrgyAeGA26W3Nx410029	intact-crc:2299D953E9E6636E|rigid:coaVFT6oIEBdeg4kOVU5UIvoGgA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15363	uniprotkb:Q28735	intact:EBI-998485|ensembl:ENSP00000262225	intact:EBI-4404338|ensembl:ENSOCUP00000004033	psi-mi:tmed2_human(display_long)|uniprotkb:TMED2(gene name)|psi-mi:TMED2(display_short)|uniprotkb:RNP24(gene name synonym)|uniprotkb:Membrane protein p24A(gene name synonym)|uniprotkb:p24 family protein beta-1(gene name synonym)|uniprotkb:p24(gene name synonym)	psi-mi:tmeda_rabit(display_long)|uniprotkb:TMED10(gene name)|psi-mi:TMED10(display_short)|uniprotkb:TMP21(gene name synonym)|uniprotkb:21 kDa transmembrane-trafficking protein(gene name synonym)|uniprotkb:Integral membrane protein p23(gene name synonym)|uniprotkb:Transmembrane protein Tmp21(gene name synonym)|uniprotkb:p24 family protein delta-1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Gommel et al. (1999)	pubmed:10214941|imex:IM-17269	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-4404356|imex:IM-17269-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000086598(gene)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001843"(neural tube closure)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|ensembl:ENST00000262225(transcript)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048205"(COPI coating of Golgi vesicle)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060717"(chorion development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0030663"(COPI-coated vesicle membrane)|go:"GO:1905069"(allantois development)|go:"GO:2000638"(regulation of SREBP signaling pathway)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|interpro:IPR036598|rcsb pdb:5AZW|reactome:R-HSA-1912420|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-6807878|refseq:NP_001308374.1|reactome:R-HSA-6811434|refseq:NP_006806.1	refseq:NP_001075877.1|refseq:XP_008270117.1|ensembl:ENSOCUG00000004669(gene)|ensembl:ENSOCUT00000004668(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005886"(plasma membrane)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0035964"(COPI-coated vesicle budding)|go:"GO:0042470"(melanosome)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0106272"(protein localization to ERGIC)|go:"GO:0106273"(cytosol to ERGIC protein transport)|go:"GO:1902003"(regulation of amyloid-beta formation)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|rcsb pdb:1M23|rcsb pdb:1P23	-	-	-	figure legend:4o|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2011/09/15	2014/10/16	rogid:TKdrbEIvtqutTXM3C6UcmMQU0eQ9606	rogid:tnzYKZyRr6y1f5Rt5XVVzKcvIIs9986	intact-crc:07033555186BFA45|rigid:Rhs0RQO8SvWmXlUNurymuELnWnE	false	-	myc tag:n-n	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)