#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9ES52	uniprotkb:P08101	intact:EBI-300210|ensembl:ENSMUSP00000127941|uniprotkb:Q3UPF9|uniprotkb:Q4U212|uniprotkb:Q61034|uniprotkb:Q61173|uniprotkb:Q61181|uniprotkb:Q9JKR7|uniprotkb:Q9JLF9|uniprotkb:Q9JLG0|uniprotkb:Q9QVN8|uniprotkb:Q9WUC2	intact:EBI-3592455|uniprotkb:P08102|uniprotkb:P12316|uniprotkb:P97917|uniprotkb:Q60938|uniprotkb:Q60939|uniprotkb:Q60940|uniprotkb:Q61170|uniprotkb:Q61558	psi-mi:ship1_mouse(display_long)|uniprotkb:Inpp5d(gene name)|psi-mi:Inpp5d(display_short)|uniprotkb:Ship(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase of 145 kDa(gene name synonym)|uniprotkb:p150Ship(gene name synonym)|uniprotkb:7a33(gene name synonym)|uniprotkb:Ship1(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase D(gene name synonym)|uniprotkb:Phosphatidylinositol-4,5-bisphosphate 5-phosphatase(gene name synonym)	psi-mi:fcgr2_mouse(display_long)|uniprotkb:Fcgr2(gene name)|psi-mi:Fcgr2(display_short)|uniprotkb:Fcgr2b(gene name synonym)|uniprotkb:Ly-17(gene name synonym)|uniprotkb:Fc gamma receptor IIB(gene name synonym)|uniprotkb:IgG Fc receptor II beta(gene name synonym)|uniprotkb:Lymphocyte antigen 17(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tridandapani et al. (1999)	mint:MINT-6731024|pubmed:9973396	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8669127|mint:MINT-8025674	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000026288(gene)|ensembl:ENSMUST00000169754(transcript)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030487"(inositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045659"(negative regulation of neutrophil differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR036860|go:"GO:0050777"(negative regulation of immune response)|rcsb pdb:6DLG|reactome:R-MMU-1660499|reactome:R-MMU-1855204|reactome:R-MMU-202424|reactome:R-MMU-210990|reactome:R-MMU-912526|refseq:NP_001103662.1|refseq:NP_001103663.1|refseq:NP_034696.2|mint:MINT-8025675(identity)|uniprotkb:Q9ES52(original identifier)	interpro:IPR036179|refseq:NP_034317.1|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001811"(negative regulation of type I hypersensitivity)|go:"GO:0002434"(immune complex clearance)|go:"GO:0002865"(negative regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0002924"(negative regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0006952"(defense response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0016358"(dendrite development)|go:"GO:0019772"(low-affinity IgG receptor activity)|go:"GO:0019864"(IgG binding)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021549"(cerebellum development)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0033030"(negative regulation of neutrophil apoptotic process)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043197"(dendritic spine)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:0002638"(negative regulation of immunoglobulin production)|reactome:R-MMU-198933|reactome:R-MMU-2029481|reactome:R-MMU-2029482|reactome:R-MMU-2029485|reactome:R-MMU-6798695|mint:MINT-8025678(identity)|uniprotkb:P08101(original identifier)	-	-	-	comment:mint|partial coverage:partial coverage	taxid:-3(unknown)|taxid:-3(Unknown)	-	2010/09/28	2014/10/16	rogid:ipXHzUIAHLTMnjElS7ngcCqFuak10090	rogid:ffILGupZ54cxJGz7XGD9GNYqtbc10090	intact-crc:1B6596FD0F78B11D|rigid:phIWFbkRLcKfItSZYmJP8fsJnqQ	false	-	phosphorylated residue:309-309(MINT-8025683)|binding-associated region:302-315(MINT-8025681)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9ES52	uniprotkb:P29353	intact:EBI-300210|ensembl:ENSMUSP00000127941|uniprotkb:Q3UPF9|uniprotkb:Q4U212|uniprotkb:Q61034|uniprotkb:Q61173|uniprotkb:Q61181|uniprotkb:Q9JKR7|uniprotkb:Q9JLF9|uniprotkb:Q9JLG0|uniprotkb:Q9QVN8|uniprotkb:Q9WUC2	intact:EBI-78835|uniprotkb:O15290|ensembl:ENSP00000357430|uniprotkb:Q5T180|uniprotkb:Q5T183|uniprotkb:Q5T184|uniprotkb:Q5T185|uniprotkb:Q5T186|uniprotkb:Q8N4K5|uniprotkb:Q96CL1|uniprotkb:B5BU19|uniprotkb:D3DV78	psi-mi:ship1_mouse(display_long)|uniprotkb:Inpp5d(gene name)|psi-mi:Inpp5d(display_short)|uniprotkb:Ship(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase of 145 kDa(gene name synonym)|uniprotkb:p150Ship(gene name synonym)|uniprotkb:7a33(gene name synonym)|uniprotkb:Ship1(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase D(gene name synonym)|uniprotkb:Phosphatidylinositol-4,5-bisphosphate 5-phosphatase(gene name synonym)	psi-mi:shc1_human(display_long)|uniprotkb:SHC1(gene name)|psi-mi:SHC1(display_short)|uniprotkb:SHC(gene name synonym)|uniprotkb:SHCA(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)|uniprotkb:SHC-transforming protein 3(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Tridandapani et al. (1999)	mint:MINT-6731024|pubmed:9973396	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8669157|mint:MINT-8032807	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000026288(gene)|ensembl:ENSMUST00000169754(transcript)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030487"(inositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045659"(negative regulation of neutrophil differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR036860|go:"GO:0050777"(negative regulation of immune response)|rcsb pdb:6DLG|reactome:R-MMU-1660499|reactome:R-MMU-1855204|reactome:R-MMU-202424|reactome:R-MMU-210990|reactome:R-MMU-912526|refseq:NP_001103662.1|refseq:NP_001103663.1|refseq:NP_034696.2|mint:MINT-8032808(identity)|uniprotkb:Q9ES52(original identifier)	go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|ensembl:ENSG00000160691(gene)|ensembl:ENST00000368445(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000980(SH2 motif)|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|mint:P29353|rcsb pdb:1MIL|rcsb pdb:1N3H|rcsb pdb:1OY2|rcsb pdb:1QG1|rcsb pdb:1SHC|rcsb pdb:1TCE|rcsb pdb:1WCP|refseq:NP_001123512.1|refseq:NP_001123513.1|refseq:NP_001189788.1|refseq:NP_003020.2|refseq:NP_892113.4|reactome:R-HSA-8851805|rcsb pdb:2L1C|rcsb pdb:4JMH|rcsb pdb:4XWX|rcsb pdb:5CZI|rcsb pdb:6DM4|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-167044|reactome:R-HSA-180336|reactome:R-HSA-210993|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-381038|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654699|reactome:R-HSA-5654704|reactome:R-HSA-5654719|reactome:R-HSA-5673001|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-9009391|reactome:R-HSA-9020558|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-9634285|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9674555|dip:DIP-699N|mint:MINT-8032811(identity)|uniprotkb:P29353(original identifier)	-	-	-	comment:homomint|comment:mint|partial coverage:partial coverage	taxid:-3(unknown)|taxid:-3(Unknown)	-	2010/09/28	2014/10/16	rogid:ipXHzUIAHLTMnjElS7ngcCqFuak10090	rogid:fe+pniai+VLkQLjeUjcpIvdDfIM9606	intact-crc:8DB45294CC245892|rigid:oWQ6Io0y8XCvIsNUumPgdkVkK8k	false	-	binding-associated region:420-433(MINT-8032814)|phosphorylated residue:427-427(MINT-8032816)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)