#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P32829	uniprotkb:P12753	intact:EBI-11255|uniprotkb:P87289|uniprotkb:Q07173|uniprotkb:D6W049|ensemblfungi:YMR224C	intact:EBI-14700|uniprotkb:D6W0U3|ensemblfungi:YNL250W	psi-mi:mre11_yeast(display_long)|uniprotkb:YM9959.06C(orf name)|uniprotkb:YMR224C(locus name)|uniprotkb:MRE11(gene name)|psi-mi:MRE11(display_short)	psi-mi:rad50_yeast(display_long)|uniprotkb:RAD50(gene name)|psi-mi:RAD50(display_short)|uniprotkb:YNL250W(locus name)|uniprotkb:N0872(orf name)|uniprotkb:153 kDa protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Usui et al. (1998)	pubmed:9845372|imex:IM-19306	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2794721|imex:IM-19306-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0010780"(meiotic DNA double-strand break formation involved in reciprocal meiotic recombination)|go:"GO:0010791"(DNA double-strand break processing involved in repair via synthesis-dependent strand annealing)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030437"(ascospore formation)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046940"(nucleoside monophosphate phosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0051037"(regulation of transcription involved in meiotic cell cycle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR003701(DNA repair exonuclease)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR007281(Mre11, DNA-binding)|interpro:IPR029052|interpro:IPR038487|interpro:IPR041796|reactome:R-SCE-1834949|reactome:R-SCE-5693548|go:"GO:0051880"(G-quadruplex DNA binding)|ensemblfungi:YMR224C(gene)|ensemblfungi:YMR224C_mRNA(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|refseq:NP_013951.1|sgd:S000004837|mint:P32829|dip:DIP-1313N	refseq:NP_014149.1|sgd:S000005194|ensemblfungi:YNL250W(gene)|ensemblfungi:YNL250W_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004017"(adenylate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0032078"(negative regulation of endodeoxyribonuclease activity)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR004584(Recombination/repair protein Rad50)|interpro:IPR013134(Zinc hook, Rad50)|interpro:IPR027417|interpro:IPR038729|reactome:R-SCE-5693548|go:"GO:0007129"(homologous chromosome pairing at meiosis)|dip:DIP-2419N|mint:P12753	-	crc64:D58433E32E852B73	crc64:58A0AA173AC5677E	comment:Two phospho-forms of Xrs2 were formed.|figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/06/16	2014/10/16	rogid:q3Y06P4MqnJ1vjF7TFYmEzYB9zI559292	rogid:5Fc4FL8mWNa6ZVO7CVaEwv5ccuk559292	intact-crc:FB63BECFB2AF469C|rigid:yZf89qyO97mr7yLmN2GqNxx5Xm4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P32829	uniprotkb:P33301	intact:EBI-11255|uniprotkb:P87289|uniprotkb:Q07173|uniprotkb:D6W049|ensemblfungi:YMR224C	intact:EBI-20599|uniprotkb:D6VT00|ensemblfungi:YDR369C	psi-mi:mre11_yeast(display_long)|uniprotkb:YM9959.06C(orf name)|uniprotkb:YMR224C(locus name)|uniprotkb:MRE11(gene name)|psi-mi:MRE11(display_short)	psi-mi:xrs2_yeast(display_long)|uniprotkb:XRS2(gene name)|psi-mi:XRS2(display_short)|uniprotkb:D9481.13(orf name)|uniprotkb:YDR369C(locus name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Usui et al. (1998)	pubmed:9845372|imex:IM-19306	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2794721|imex:IM-19306-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0010780"(meiotic DNA double-strand break formation involved in reciprocal meiotic recombination)|go:"GO:0010791"(DNA double-strand break processing involved in repair via synthesis-dependent strand annealing)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030437"(ascospore formation)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046940"(nucleoside monophosphate phosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0051037"(regulation of transcription involved in meiotic cell cycle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR003701(DNA repair exonuclease)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR007281(Mre11, DNA-binding)|interpro:IPR029052|interpro:IPR038487|interpro:IPR041796|reactome:R-SCE-1834949|reactome:R-SCE-5693548|go:"GO:0051880"(G-quadruplex DNA binding)|ensemblfungi:YMR224C(gene)|ensemblfungi:YMR224C_mRNA(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|refseq:NP_013951.1|sgd:S000004837|mint:P32829|dip:DIP-1313N	sgd:S000002777|refseq:NP_010657.3|ensemblfungi:YDR369C(gene)|ensemblfungi:YDR369C_mRNA(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0003677"(DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006284"(base-excision repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|dip:DIP-2420N|mint:P33301	-	crc64:D58433E32E852B73	crc64:833DAD6D20F6693E	comment:Two phospho-forms of Xrs2 were formed.|figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/06/16	2014/10/16	rogid:q3Y06P4MqnJ1vjF7TFYmEzYB9zI559292	rogid:o505mxGL67ZY1mBUls7e15A4JTY559292	intact-crc:FB63BECFB2AF469C|rigid:yZf89qyO97mr7yLmN2GqNxx5Xm4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P32829	uniprotkb:P12753	intact:EBI-11255|uniprotkb:P87289|uniprotkb:Q07173|uniprotkb:D6W049|ensemblfungi:YMR224C	intact:EBI-14700|uniprotkb:D6W0U3|ensemblfungi:YNL250W	psi-mi:mre11_yeast(display_long)|uniprotkb:YM9959.06C(orf name)|uniprotkb:YMR224C(locus name)|uniprotkb:MRE11(gene name)|psi-mi:MRE11(display_short)	psi-mi:rad50_yeast(display_long)|uniprotkb:RAD50(gene name)|psi-mi:RAD50(display_short)|uniprotkb:YNL250W(locus name)|uniprotkb:N0872(orf name)|uniprotkb:153 kDa protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Usui et al. (1998)	pubmed:9845372|imex:IM-19306	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2794765|imex:IM-19306-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0010780"(meiotic DNA double-strand break formation involved in reciprocal meiotic recombination)|go:"GO:0010791"(DNA double-strand break processing involved in repair via synthesis-dependent strand annealing)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030437"(ascospore formation)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046940"(nucleoside monophosphate phosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0051037"(regulation of transcription involved in meiotic cell cycle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR003701(DNA repair exonuclease)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR007281(Mre11, DNA-binding)|interpro:IPR029052|interpro:IPR038487|interpro:IPR041796|reactome:R-SCE-1834949|reactome:R-SCE-5693548|go:"GO:0051880"(G-quadruplex DNA binding)|ensemblfungi:YMR224C(gene)|ensemblfungi:YMR224C_mRNA(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|refseq:NP_013951.1|sgd:S000004837|mint:P32829|dip:DIP-1313N	refseq:NP_014149.1|sgd:S000005194|ensemblfungi:YNL250W(gene)|ensemblfungi:YNL250W_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004017"(adenylate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0032078"(negative regulation of endodeoxyribonuclease activity)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR004584(Recombination/repair protein Rad50)|interpro:IPR013134(Zinc hook, Rad50)|interpro:IPR027417|interpro:IPR038729|reactome:R-SCE-5693548|go:"GO:0007129"(homologous chromosome pairing at meiosis)|dip:DIP-2419N|mint:P12753	-	crc64:D58433E32E852B73	crc64:58A0AA173AC5677E	comment:Interaction observed in XRS2-/- cells.|figure legend:Fig. 1A, 6B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/06/16	2014/10/16	rogid:q3Y06P4MqnJ1vjF7TFYmEzYB9zI559292	rogid:5Fc4FL8mWNa6ZVO7CVaEwv5ccuk559292	intact-crc:6E1218ED0B6D1427|rigid:vJK543uqRq1hmrItqlQd9FtIePA	false	mutation disrupting interaction:225-225,213-213	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P32829	uniprotkb:P33301	intact:EBI-11255|uniprotkb:P87289|uniprotkb:Q07173|uniprotkb:D6W049|ensemblfungi:YMR224C	intact:EBI-20599|uniprotkb:D6VT00|ensemblfungi:YDR369C	psi-mi:mre11_yeast(display_long)|uniprotkb:YM9959.06C(orf name)|uniprotkb:YMR224C(locus name)|uniprotkb:MRE11(gene name)|psi-mi:MRE11(display_short)	psi-mi:xrs2_yeast(display_long)|uniprotkb:XRS2(gene name)|psi-mi:XRS2(display_short)|uniprotkb:D9481.13(orf name)|uniprotkb:YDR369C(locus name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Usui et al. (1998)	pubmed:9845372|imex:IM-19306	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2794779|imex:IM-19306-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0010780"(meiotic DNA double-strand break formation involved in reciprocal meiotic recombination)|go:"GO:0010791"(DNA double-strand break processing involved in repair via synthesis-dependent strand annealing)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030437"(ascospore formation)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046940"(nucleoside monophosphate phosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0051037"(regulation of transcription involved in meiotic cell cycle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR003701(DNA repair exonuclease)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR007281(Mre11, DNA-binding)|interpro:IPR029052|interpro:IPR038487|interpro:IPR041796|reactome:R-SCE-1834949|reactome:R-SCE-5693548|go:"GO:0051880"(G-quadruplex DNA binding)|ensemblfungi:YMR224C(gene)|ensemblfungi:YMR224C_mRNA(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|refseq:NP_013951.1|sgd:S000004837|mint:P32829|dip:DIP-1313N	sgd:S000002777|refseq:NP_010657.3|ensemblfungi:YDR369C(gene)|ensemblfungi:YDR369C_mRNA(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0003677"(DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006284"(base-excision repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|dip:DIP-2420N|mint:P33301	-	crc64:D58433E32E852B73	crc64:833DAD6D20F6693E	comment:Two phospho-forms of Xrs2 were formed.|figure legend:Fig. 1A|comment:Interaction observed in Rad50-/- cells.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/06/16	2014/10/16	rogid:q3Y06P4MqnJ1vjF7TFYmEzYB9zI559292	rogid:o505mxGL67ZY1mBUls7e15A4JTY559292	intact-crc:221BDC63613D06B7|rigid:W5fZhoFxd2KhSRYKUjeDENmKYCk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P33301	uniprotkb:P12753	intact:EBI-20599|uniprotkb:D6VT00|ensemblfungi:YDR369C	intact:EBI-14700|uniprotkb:D6W0U3|ensemblfungi:YNL250W	psi-mi:xrs2_yeast(display_long)|uniprotkb:XRS2(gene name)|psi-mi:XRS2(display_short)|uniprotkb:D9481.13(orf name)|uniprotkb:YDR369C(locus name)	psi-mi:rad50_yeast(display_long)|uniprotkb:RAD50(gene name)|psi-mi:RAD50(display_short)|uniprotkb:YNL250W(locus name)|uniprotkb:N0872(orf name)|uniprotkb:153 kDa protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Usui et al. (1998)	pubmed:9845372|imex:IM-19306	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2794791|imex:IM-19306-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000002777|refseq:NP_010657.3|ensemblfungi:YDR369C(gene)|ensemblfungi:YDR369C_mRNA(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0003677"(DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006284"(base-excision repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|dip:DIP-2420N|mint:P33301	refseq:NP_014149.1|sgd:S000005194|ensemblfungi:YNL250W(gene)|ensemblfungi:YNL250W_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004017"(adenylate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0032078"(negative regulation of endodeoxyribonuclease activity)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR004584(Recombination/repair protein Rad50)|interpro:IPR013134(Zinc hook, Rad50)|interpro:IPR027417|interpro:IPR038729|reactome:R-SCE-5693548|go:"GO:0007129"(homologous chromosome pairing at meiosis)|dip:DIP-2419N|mint:P12753	-	crc64:833DAD6D20F6693E	crc64:58A0AA173AC5677E	comment:Two phospho-forms of Xrs2 were observed.|figure legend:Figs. 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/06/16	2014/10/16	rogid:o505mxGL67ZY1mBUls7e15A4JTY559292	rogid:5Fc4FL8mWNa6ZVO7CVaEwv5ccuk559292	intact-crc:ECD0CD1106712C45|rigid:yZf89qyO97mr7yLmN2GqNxx5Xm4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P33301	uniprotkb:P32829	intact:EBI-20599|uniprotkb:D6VT00|ensemblfungi:YDR369C	intact:EBI-11255|uniprotkb:P87289|uniprotkb:Q07173|uniprotkb:D6W049|ensemblfungi:YMR224C	psi-mi:xrs2_yeast(display_long)|uniprotkb:XRS2(gene name)|psi-mi:XRS2(display_short)|uniprotkb:D9481.13(orf name)|uniprotkb:YDR369C(locus name)	psi-mi:mre11_yeast(display_long)|uniprotkb:YM9959.06C(orf name)|uniprotkb:YMR224C(locus name)|uniprotkb:MRE11(gene name)|psi-mi:MRE11(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Usui et al. (1998)	pubmed:9845372|imex:IM-19306	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2794791|imex:IM-19306-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000002777|refseq:NP_010657.3|ensemblfungi:YDR369C(gene)|ensemblfungi:YDR369C_mRNA(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0003677"(DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006284"(base-excision repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|dip:DIP-2420N|mint:P33301	go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0010780"(meiotic DNA double-strand break formation involved in reciprocal meiotic recombination)|go:"GO:0010791"(DNA double-strand break processing involved in repair via synthesis-dependent strand annealing)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030437"(ascospore formation)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046940"(nucleoside monophosphate phosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0051037"(regulation of transcription involved in meiotic cell cycle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR003701(DNA repair exonuclease)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR007281(Mre11, DNA-binding)|interpro:IPR029052|interpro:IPR038487|interpro:IPR041796|reactome:R-SCE-1834949|reactome:R-SCE-5693548|go:"GO:0051880"(G-quadruplex DNA binding)|ensemblfungi:YMR224C(gene)|ensemblfungi:YMR224C_mRNA(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|refseq:NP_013951.1|sgd:S000004837|mint:P32829|dip:DIP-1313N	-	crc64:833DAD6D20F6693E	crc64:D58433E32E852B73	comment:Two phospho-forms of Xrs2 were observed.|figure legend:Figs. 1B, 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/06/16	2014/10/16	rogid:o505mxGL67ZY1mBUls7e15A4JTY559292	rogid:q3Y06P4MqnJ1vjF7TFYmEzYB9zI559292	intact-crc:ECD0CD1106712C45|rigid:yZf89qyO97mr7yLmN2GqNxx5Xm4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P33301	uniprotkb:P32829	intact:EBI-20599|uniprotkb:D6VT00|ensemblfungi:YDR369C	intact:EBI-11255|uniprotkb:P87289|uniprotkb:Q07173|uniprotkb:D6W049|ensemblfungi:YMR224C	psi-mi:xrs2_yeast(display_long)|uniprotkb:XRS2(gene name)|psi-mi:XRS2(display_short)|uniprotkb:D9481.13(orf name)|uniprotkb:YDR369C(locus name)	psi-mi:mre11_yeast(display_long)|uniprotkb:YM9959.06C(orf name)|uniprotkb:YMR224C(locus name)|uniprotkb:MRE11(gene name)|psi-mi:MRE11(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Usui et al. (1998)	pubmed:9845372|imex:IM-19306	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2794797|imex:IM-19306-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000002777|refseq:NP_010657.3|ensemblfungi:YDR369C(gene)|ensemblfungi:YDR369C_mRNA(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0003677"(DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006284"(base-excision repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|dip:DIP-2420N|mint:P33301	go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0010780"(meiotic DNA double-strand break formation involved in reciprocal meiotic recombination)|go:"GO:0010791"(DNA double-strand break processing involved in repair via synthesis-dependent strand annealing)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030437"(ascospore formation)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046940"(nucleoside monophosphate phosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0051037"(regulation of transcription involved in meiotic cell cycle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR003701(DNA repair exonuclease)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR007281(Mre11, DNA-binding)|interpro:IPR029052|interpro:IPR038487|interpro:IPR041796|reactome:R-SCE-1834949|reactome:R-SCE-5693548|go:"GO:0051880"(G-quadruplex DNA binding)|ensemblfungi:YMR224C(gene)|ensemblfungi:YMR224C_mRNA(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|refseq:NP_013951.1|sgd:S000004837|mint:P32829|dip:DIP-1313N	-	crc64:833DAD6D20F6693E	crc64:D58433E32E852B73	comment:Two phospho-forms of Xrs2 were observed.|figure legend:Fig. 1B|comment:Interaction observed in Rad50-/- cells.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/06/16	2014/10/16	rogid:o505mxGL67ZY1mBUls7e15A4JTY559292	rogid:q3Y06P4MqnJ1vjF7TFYmEzYB9zI559292	intact-crc:DB43594963EB9293|rigid:W5fZhoFxd2KhSRYKUjeDENmKYCk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P32829	uniprotkb:P12753	intact:EBI-11255|uniprotkb:P87289|uniprotkb:Q07173|uniprotkb:D6W049|ensemblfungi:YMR224C	intact:EBI-14700|uniprotkb:D6W0U3|ensemblfungi:YNL250W	psi-mi:mre11_yeast(display_long)|uniprotkb:YM9959.06C(orf name)|uniprotkb:YMR224C(locus name)|uniprotkb:MRE11(gene name)|psi-mi:MRE11(display_short)	psi-mi:rad50_yeast(display_long)|uniprotkb:RAD50(gene name)|psi-mi:RAD50(display_short)|uniprotkb:YNL250W(locus name)|uniprotkb:N0872(orf name)|uniprotkb:153 kDa protein(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Usui et al. (1998)	pubmed:9845372|imex:IM-19306	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2794813|imex:IM-19306-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0010780"(meiotic DNA double-strand break formation involved in reciprocal meiotic recombination)|go:"GO:0010791"(DNA double-strand break processing involved in repair via synthesis-dependent strand annealing)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030437"(ascospore formation)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046940"(nucleoside monophosphate phosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0051037"(regulation of transcription involved in meiotic cell cycle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR003701(DNA repair exonuclease)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR007281(Mre11, DNA-binding)|interpro:IPR029052|interpro:IPR038487|interpro:IPR041796|reactome:R-SCE-1834949|reactome:R-SCE-5693548|go:"GO:0051880"(G-quadruplex DNA binding)|ensemblfungi:YMR224C(gene)|ensemblfungi:YMR224C_mRNA(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|refseq:NP_013951.1|sgd:S000004837|mint:P32829|dip:DIP-1313N	refseq:NP_014149.1|sgd:S000005194|ensemblfungi:YNL250W(gene)|ensemblfungi:YNL250W_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004017"(adenylate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0032078"(negative regulation of endodeoxyribonuclease activity)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR004584(Recombination/repair protein Rad50)|interpro:IPR013134(Zinc hook, Rad50)|interpro:IPR027417|interpro:IPR038729|reactome:R-SCE-5693548|go:"GO:0007129"(homologous chromosome pairing at meiosis)|dip:DIP-2419N|mint:P12753	go:"GO:0005634"(nucleus)|go:"GO:0007126"	crc64:D58433E32E852B73	crc64:58A0AA173AC5677E	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/06/16	2014/10/16	rogid:q3Y06P4MqnJ1vjF7TFYmEzYB9zI559292	rogid:5Fc4FL8mWNa6ZVO7CVaEwv5ccuk559292	intact-crc:2FABD90B3C696A59|rigid:vJK543uqRq1hmrItqlQd9FtIePA	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P33301	uniprotkb:P32829	intact:EBI-20599|uniprotkb:D6VT00|ensemblfungi:YDR369C	intact:EBI-11255|uniprotkb:P87289|uniprotkb:Q07173|uniprotkb:D6W049|ensemblfungi:YMR224C	psi-mi:xrs2_yeast(display_long)|uniprotkb:XRS2(gene name)|psi-mi:XRS2(display_short)|uniprotkb:D9481.13(orf name)|uniprotkb:YDR369C(locus name)	psi-mi:mre11_yeast(display_long)|uniprotkb:YM9959.06C(orf name)|uniprotkb:YMR224C(locus name)|uniprotkb:MRE11(gene name)|psi-mi:MRE11(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Usui et al. (1998)	pubmed:9845372|imex:IM-19306	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2794820|imex:IM-19306-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000002777|refseq:NP_010657.3|ensemblfungi:YDR369C(gene)|ensemblfungi:YDR369C_mRNA(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0003677"(DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006284"(base-excision repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|dip:DIP-2420N|mint:P33301	go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0010780"(meiotic DNA double-strand break formation involved in reciprocal meiotic recombination)|go:"GO:0010791"(DNA double-strand break processing involved in repair via synthesis-dependent strand annealing)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030437"(ascospore formation)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046940"(nucleoside monophosphate phosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0051037"(regulation of transcription involved in meiotic cell cycle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR003701(DNA repair exonuclease)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR007281(Mre11, DNA-binding)|interpro:IPR029052|interpro:IPR038487|interpro:IPR041796|reactome:R-SCE-1834949|reactome:R-SCE-5693548|go:"GO:0051880"(G-quadruplex DNA binding)|ensemblfungi:YMR224C(gene)|ensemblfungi:YMR224C_mRNA(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|refseq:NP_013951.1|sgd:S000004837|mint:P32829|dip:DIP-1313N	go:"GO:0005634"(nucleus)|go:"GO:0007126"	crc64:833DAD6D20F6693E	crc64:D58433E32E852B73	figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/06/16	2014/10/16	rogid:o505mxGL67ZY1mBUls7e15A4JTY559292	rogid:q3Y06P4MqnJ1vjF7TFYmEzYB9zI559292	intact-crc:F07893AF14225FED|rigid:W5fZhoFxd2KhSRYKUjeDENmKYCk	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P32829	intact:EBI-1203195	intact:EBI-11255|uniprotkb:P87289|uniprotkb:Q07173|uniprotkb:D6W049|ensemblfungi:YMR224C	-	psi-mi:mre11_yeast(display_long)|uniprotkb:YM9959.06C(orf name)|uniprotkb:YMR224C(locus name)|uniprotkb:MRE11(gene name)|psi-mi:MRE11(display_short)	psi-mi:m13(display_short)|psi-mi:EBI-1203195(display_long)	psi-mi:"MI:0415"(enzymatic study)	Usui et al. (1998)	pubmed:9845372|imex:IM-19306	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:10870(bpm13)|taxid:10870(Enterobacteria phage M13)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2794847|imex:IM-19306-9	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0010780"(meiotic DNA double-strand break formation involved in reciprocal meiotic recombination)|go:"GO:0010791"(DNA double-strand break processing involved in repair via synthesis-dependent strand annealing)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030437"(ascospore formation)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046940"(nucleoside monophosphate phosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0051037"(regulation of transcription involved in meiotic cell cycle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR003701(DNA repair exonuclease)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR007281(Mre11, DNA-binding)|interpro:IPR029052|interpro:IPR038487|interpro:IPR041796|reactome:R-SCE-1834949|reactome:R-SCE-5693548|go:"GO:0051880"(G-quadruplex DNA binding)|ensemblfungi:YMR224C(gene)|ensemblfungi:YMR224C_mRNA(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|refseq:NP_013951.1|sgd:S000004837|mint:P32829|dip:DIP-1313N	ddbj/embl/genbank:V00604(primary-reference)	go:"GO:0008310"(single-stranded DNA 3'-5' exodeoxyribonuclease activity)	crc64:D58433E32E852B73	-	comment:M13mp8 circular viral ssDNA was converted to the linear form, and further incubation resulted in extensive degradation of the substrate suggesting 3'-to-5' ssDNA exonuclease activity.|figure legend:Figs. 4, 5C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/16	2014/10/16	rogid:q3Y06P4MqnJ1vjF7TFYmEzYB9zI559292	-	intact-crc:6626FB82704DF294	false	glutathione s tranferase tag:?-?|his tag:?-?|binding-associated region:1-512	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32829	uniprotkb:P12753	intact:EBI-11255|uniprotkb:P87289|uniprotkb:Q07173|uniprotkb:D6W049|ensemblfungi:YMR224C	intact:EBI-14700|uniprotkb:D6W0U3|ensemblfungi:YNL250W	psi-mi:mre11_yeast(display_long)|uniprotkb:YM9959.06C(orf name)|uniprotkb:YMR224C(locus name)|uniprotkb:MRE11(gene name)|psi-mi:MRE11(display_short)	psi-mi:rad50_yeast(display_long)|uniprotkb:RAD50(gene name)|psi-mi:RAD50(display_short)|uniprotkb:YNL250W(locus name)|uniprotkb:N0872(orf name)|uniprotkb:153 kDa protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Usui et al. (1998)	pubmed:9845372|imex:IM-19306	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2794934|imex:IM-19306-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0010780"(meiotic DNA double-strand break formation involved in reciprocal meiotic recombination)|go:"GO:0010791"(DNA double-strand break processing involved in repair via synthesis-dependent strand annealing)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030437"(ascospore formation)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046940"(nucleoside monophosphate phosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0051037"(regulation of transcription involved in meiotic cell cycle)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR003701(DNA repair exonuclease)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR007281(Mre11, DNA-binding)|interpro:IPR029052|interpro:IPR038487|interpro:IPR041796|reactome:R-SCE-1834949|reactome:R-SCE-5693548|go:"GO:0051880"(G-quadruplex DNA binding)|ensemblfungi:YMR224C(gene)|ensemblfungi:YMR224C_mRNA(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|refseq:NP_013951.1|sgd:S000004837|mint:P32829|dip:DIP-1313N	refseq:NP_014149.1|sgd:S000005194|ensemblfungi:YNL250W(gene)|ensemblfungi:YNL250W_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0004017"(adenylate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0032078"(negative regulation of endodeoxyribonuclease activity)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0035753"(maintenance of DNA trinucleotide repeats)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|interpro:IPR004584(Recombination/repair protein Rad50)|interpro:IPR013134(Zinc hook, Rad50)|interpro:IPR027417|interpro:IPR038729|reactome:R-SCE-5693548|go:"GO:0007129"(homologous chromosome pairing at meiosis)|dip:DIP-2419N|mint:P12753	-	crc64:D58433E32E852B73	crc64:58A0AA173AC5677E	comment:The S1 and S2 segments bound to Rad50  with similar efficiency showing that Mre11 has two binding sites for the Rad50.|figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/16	2014/10/16	rogid:q3Y06P4MqnJ1vjF7TFYmEzYB9zI559292	rogid:5Fc4FL8mWNa6ZVO7CVaEwv5ccuk559292	intact-crc:2972AA4D47170A7A|rigid:vJK543uqRq1hmrItqlQd9FtIePA	false	glutathione s tranferase tag:?-?	flag tag:?-?|his tag:?-?|sufficient binding region:1-292(IPR004843)|sufficient binding region:293-512(IPR007281)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)