#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P42226 uniprotkb:P24394 intact:EBI-1186478|uniprotkb:Q5FBW5|uniprotkb:Q71UP4|uniprotkb:A8K316|uniprotkb:B7ZA27|uniprotkb:F5GXI9|intact:EBI-28971408|ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENSP00000438451|ensembl:ENSP00000451742 intact:EBI-367009|uniprotkb:Q96P01|uniprotkb:Q9H181|uniprotkb:Q9H182|uniprotkb:Q9H183|uniprotkb:Q9H184|uniprotkb:Q9H185|uniprotkb:Q9H186|uniprotkb:Q9H187|uniprotkb:Q9H188|uniprotkb:B4E076|uniprotkb:B9EKU8|uniprotkb:H3BSY5|ensembl:ENSP00000379111|ensembl:ENSP00000441667 psi-mi:stat6_human(display_long)|uniprotkb:IL-4 Stat(gene name synonym)|uniprotkb:STAT6(gene name)|psi-mi:STAT6(display_short) psi-mi:il4ra_human(display_long)|uniprotkb:IL4R(gene name)|psi-mi:IL4R(display_short)|uniprotkb:582J2.1(orf name)|uniprotkb:IL4RA(gene name synonym) psi-mi:"MI:0096"(pull down) Mikita et al. (1998) mint:MINT-6730923|pubmed:9651359 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8690248|mint:MINT-8038160 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000300134|ensembl:ENSP00000401486|ensembl:ENST00000537215|ensembl:ENSP00000444530|ensembl:ENST00000538913|ensembl:ENSP00000445409|ensembl:ENSP00000438451|ensembl:ENSP00000451742|refseq:NP_001171549.1|refseq:NP_001171550.1|refseq:NP_003144.3|refseq:XP_006719638.1|refseq:NP_001171551.1|ensembl:ENSG00000166888(gene)|ensembl:ENST00000300134(transcript)|ensembl:ENST00000454075(transcript)|ensembl:ENST00000543873(transcript)|ensembl:ENST00000556155(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|mint:P42226|rcsb pdb:1OJ5|rcsb pdb:4Y5U|rcsb pdb:4Y5W|rcsb pdb:5D39|rcsb pdb:5NWM|rcsb pdb:5NWX|reactome:R-HSA-186763|reactome:R-HSA-3249367|reactome:R-HSA-6785807|dip:DIP-39855N|mint:MINT-8038161(identity)|uniprotkb:P42226(original identifier) refseq:NP_001244336.1|refseq:NP_000409.1|refseq:XP_011544127.1|refseq:XP_011544128.1|refseq:XP_011544129.1|refseq:NP_001244335.1|go:"GO:0045626"(negative regulation of T-helper 1 cell differentiation)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901741"(positive regulation of myoblast fusion)|rcsb pdb:3BPL|rcsb pdb:3BPN|rcsb pdb:3BPO|go:"GO:1990834"(response to odorant)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015319(Interleukin-4 receptor alpha chain, N-terminal)|interpro:IPR036116|rcsb pdb:1IAR|rcsb pdb:5E4E|rcsb pdb:6OEL|rcsb pdb:1IRS|rcsb pdb:1ITE|rcsb pdb:6WGL|reactome:R-HSA-6785807|ensembl:ENSG00000077238(gene)|ensembl:ENST00000395762(transcript)|go:"GO:0042832"(defense response to protozoan)|ensembl:ENST00000543915(transcript)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043235"(receptor complex)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043627"(response to estrogen)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0004913"(interleukin-4 receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0030728"(ovulation)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042127"(regulation of cell population proliferation)|dip:DIP-3223N|mint:MINT-8038164(identity)|uniprotkb:P24394(original identifier) - - - comment:homomint|comment:mint|partial coverage:partial coverage taxid:-3(unknown)|taxid:-3(Unknown) - 2010/09/29 2014/10/16 rogid:BuSBP6PMmA3hcOmnaH3/r4XoiVw9606 rogid:18E1cLQsvHGc0WRFqUzuGssLVg09606 intact-crc:8C0F8B0B059B0FA2|rigid:SoERC/5XB4Hrt6+2bboCDgCyWJU false - binding-associated region:624-637(MINT-8038167)|phosphorylated residue:631-631(MINT-8038169) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)