#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q6P6U0 uniprotkb:P14317 intact:EBI-8648405|ensembl:ENSRNOP00000013779|ensembl:ENSRNOP00000075272|uniprotkb:Q63206|intact:UNK-5464446 intact:EBI-750369|uniprotkb:B4DQ69|uniprotkb:Q53Y93|uniprotkb:Q6IBK9|uniprotkb:Q9UDK0|ensembl:ENSP00000320176 psi-mi:fgr_rat(display_long)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)|uniprotkb:p55-Fgr(gene name synonym)|uniprotkb:Fgr(gene name)|psi-mi:Fgr(display_short) psi-mi:hcls1_human(display_long)|uniprotkb:Hematopoietic cell-specific LYN substrate 1(gene name synonym)|uniprotkb:LckBP1(gene name synonym)|uniprotkb:p75(gene name synonym)|uniprotkb:HCLS1(gene name)|psi-mi:HCLS1(display_short)|uniprotkb:HS1(gene name synonym) psi-mi:"MI:0415"(enzymatic study) Ruzzene et al. (1997) mint:MINT-6730787|pubmed:9183008|doi:10.1111/j.1432-1033.1997.t01-1-00701 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8648402|mint:MINT-8026797 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSRNOG00000009912(gene)|ensembl:ENSRNOT00000013778(transcript)|ensembl:ENSRNOT00000085674(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016235"(aggresome)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035693|interpro:IPR036028|interpro:IPR036860|reactome:R-RNO-2029481|reactome:R-RNO-432142|reactome:R-RNO-6798695|go:"GO:0005886"(plasma membrane)|refseq:NP_077059.2|rgd:621319|refseq:XP_006239141.1|refseq:XP_006239142.1|refseq:XP_006239143.1|refseq:XP_006239144.1|mint:MINT-8026798(identity)|uniprotkb:Q63206(original identifier) ensembl:ENSP00000320176|ensembl:ENST00000495491|ensembl:ENSP00000418299|refseq:NP_001278970.1|refseq:NP_005326.2|ensembl:ENSG00000180353(gene)|ensembl:ENST00000314583(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000107"(negative regulation of leukocyte apoptotic process)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR028534|interpro:IPR036028|mint:P14317|mint:MINT-8026801(identity)|uniprotkb:P14317(original identifier) - comment:mint - comment:mint|partial coverage:partial coverage taxid:-3(unknown)|taxid:-3(Unknown) - 2010/09/28 2014/10/16 rogid:OZ7YWHQpxXY39UOKqFYmgKrJHtg10116 rogid:sViasWf8ZiLb/dmYn3VEr7t2L0Y9606 intact-crc:92898ECD25E6D4CA|rigid:Fg8AHcS6/dS+0orusBxCRTa88Rw false - phosphorylated residue:397-397(MINT-8026806)|binding-associated region:390-403(MINT-8026804) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)