#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q00655	uniprotkb:P15498	intact:EBI-8669196|intact:MINT-6622752	intact:EBI-625518|ensembl:ENSP00000472929|uniprotkb:Q15860|uniprotkb:B4DVK9|uniprotkb:M0QXX6	psi-mi:ksyk_pig(display_long)|uniprotkb:SYK(gene name)|psi-mi:SYK(display_short)|uniprotkb:Spleen tyrosine kinase(gene name synonym)	psi-mi:vav_human(display_long)|uniprotkb:VAV1(gene name)|psi-mi:VAV1(display_short)|uniprotkb:VAV(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Deckert et al. (1996)	pubmed:8986718|mint:MINT-6730716	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8669193|mint:MINT-8035291	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031623"(receptor internalization)|go:"GO:0032009"(early phagosome)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032928"(regulation of superoxide anion generation)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038156"(interleukin-3-mediated signaling pathway)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043313"(regulation of neutrophil degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090237"(regulation of arachidonic acid secretion)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001945"(lymph vessel development)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002554"(serotonin secretion by platelet)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|interpro:IPR023420|refseq:NP_001098422.1|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR020635|interpro:IPR011009(Protein kinase-like)|interpro:IPR000980(SH2 motif)|interpro:IPR035838|interpro:IPR036860|mint:MINT-8035295(identity)|uniprotkb:Q00655(original identifier)	go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0072593"(reactive oxygen species metabolic process)|ensembl:ENSG00000141968(gene)|ensembl:ENST00000602142(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030168"(platelet activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031295"(T cell costimulation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0140031"(phosphorylation-dependent protein binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR028530|interpro:IPR035729|interpro:IPR035730|interpro:IPR035879|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P15498|rcsb pdb:2CRH|rcsb pdb:2LCT|rcsb pdb:2MC1|rcsb pdb:2ROR|rcsb pdb:3BJI|rcsb pdb:3KY9|rcsb pdb:6NEW|rcsb pdb:6NF1|rcsb pdb:6NFA|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2219530|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-389359|reactome:R-HSA-416482|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5218920|reactome:R-HSA-6811558|reactome:R-HSA-8980692|reactome:R-HSA-9013149|reactome:R-HSA-9013408|reactome:R-HSA-9027284|reactome:R-HSA-912631|reactome:R-HSA-9664422|reactome:R-HSA-983695|reactome:R-HSA-9013404|refseq:NP_005419.2|refseq:NP_001245136.1|dip:DIP-1061N|mint:MINT-8035292(identity)|uniprotkb:P15498(original identifier)	-	function:"Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-341 and Tyr-345. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion"|comment:mint	-	comment:mint|partial coverage:partial coverage	taxid:-3(unknown)|taxid:-3(Unknown)	-	2010/09/28	2014/10/16	rogid:kA7K7L2Ygxrd7RMAJFBV0EwlvEA9823	rogid:bQbV6leh4WHm+d0VGVCMuZtR6pU9606	intact-crc:C7818DE75713083A|rigid:9W3/BT/dzIA3zfprP0H6Pk42JVU	false	phosphorylated residue:341-341(MINT-8035300)|binding-associated region:334-347(MINT-8035298)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)