#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P16234 uniprotkb:P19174 intact:EBI-2861522|uniprotkb:Q96KZ7|uniprotkb:B2RE69|uniprotkb:Q9UD28|uniprotkb:E9PBH0|uniprotkb:Q6P4H5|ensembl:ENSP00000257290 intact:EBI-79387|uniprotkb:Q2V575|uniprotkb:B9EGH4|uniprotkb:B7ZLY7|uniprotkb:E1P5W4|intact:EBI-3959906|ensembl:ENSP00000362368 psi-mi:pgfra_human(display_long)|uniprotkb:PDGFRA(gene name)|psi-mi:PDGFRA(display_short)|uniprotkb:CD140 antigen-like family member A(gene name synonym)|uniprotkb:CD140a antigen(gene name synonym)|uniprotkb:Alpha-type platelet-derived growth factor receptor(gene name synonym)|uniprotkb:Alpha platelet-derived growth factor receptor(gene name synonym)|uniprotkb:Platelet-derived growth factor receptor 2(gene name synonym)|uniprotkb:RHEPDGFRA(gene name synonym)|uniprotkb:PDGFR2(gene name synonym)|uniprotkb:Platelet-derived growth factor alpha receptor(gene name synonym) psi-mi:plcg1_human(display_long)|uniprotkb:PLC-148(gene name synonym)|uniprotkb:PLC1(gene name synonym)|uniprotkb:Phospholipase C-II(gene name synonym)|uniprotkb:PLCG1(gene name)|psi-mi:PLCG1(display_short)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym) psi-mi:"MI:0045"(experimental interaction detection) Eriksson et al. (1995) mint:MINT-6730369|pubmed:7535778 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8572159|mint:MINT-8033627 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001334758.1|refseq:NP_006197.1|refseq:XP_005265800.1|dip:DIP-5736N|ensembl:ENSG00000134853(gene)|ensembl:ENST00000257290(transcript)|go:"GO:0001553"(luteinization)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001775"(cell activation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005018"(platelet-derived growth factor alpha-receptor activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005929"(cilium)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030054"(cell junction)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030324"(lung development)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030539"(male genitalia development)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0072277"(metanephric glomerular capillary formation)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000739"(regulation of mesenchymal stem cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027290|interpro:IPR036179|rcsb pdb:1GQ5|rcsb pdb:5GRN|rcsb pdb:5K5X|rcsb pdb:6A32|rcsb pdb:6JOI|rcsb pdb:6JOJ|rcsb pdb:6JOK|rcsb pdb:6JOL|rcsb pdb:7LBF|reactome:R-HSA-1257604|reactome:R-HSA-186763|go:"GO:0060021"(roof of mouth development)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035790"(platelet-derived growth factor receptor-alpha signaling pathway)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0038091"(positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|reactome:R-HSA-186797|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674396|reactome:R-HSA-9674401|reactome:R-HSA-9674403|reactome:R-HSA-9674404|reactome:R-HSA-9674428|mint:MINT-8033631(identity)|uniprotkb:P16234(original identifier) refseq:NP_002651.2|refseq:NP_877963.1|dip:DIP-100N|ensembl:ENSG00000124181(gene)|ensembl:ENST00000373271(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042995"(cell projection)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR035724|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P19174|rcsb pdb:1HSQ|rcsb pdb:2HSP|rcsb pdb:4EY0|rcsb pdb:4FBN|rcsb pdb:7NXE|reactome:R-HSA-1169408|reactome:R-HSA-1236382|reactome:R-HSA-1251932|reactome:R-HSA-1489509|reactome:R-HSA-167021|reactome:R-HSA-1855204|reactome:R-HSA-186763|reactome:R-HSA-202433|reactome:R-HSA-2029485|reactome:R-HSA-210990|reactome:R-HSA-212718|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-418890|reactome:R-HSA-5218921|reactome:R-HSA-5637810|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-9026527|reactome:R-HSA-9027277|reactome:R-HSA-9034793|reactome:R-HSA-9664323|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|mint:MINT-8033628(identity)|uniprotkb:P19174(original identifier) - - - comment:homomint|comment:mint|partial coverage:partial coverage taxid:-3(unknown)|taxid:-3(Unknown) - 2010/09/28 2014/10/16 rogid:MkKEhNlBrHysJ4mct8Rvqjy2f7U9606 rogid:pJsNLrqg3cUj0SdjoyLf+/91yBo9606 intact-crc:6EC5E5C703514792|rigid:6OOBwQTIC13IbxFWpIb7ebRIW7o false binding-associated region:1011-1024(MINT-8033634)|phosphorylated residue:1018-1018(MINT-8033636) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)