#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q06124	uniprotkb:P35568	intact:EBI-297779|uniprotkb:Q96HD7|ensembl:ENSP00000340944|uniprotkb:A8K1D9|intact:EBI-14351608|intact:EBI-11988773|intact:EBI-13004965	intact:EBI-517592|intact:EBI-28983786|ensembl:ENSP00000304895	psi-mi:ptn11_human(display_long)|uniprotkb:PTPN11(gene name)|psi-mi:PTPN11(display_short)|uniprotkb:PTP2C(gene name synonym)|uniprotkb:SHPTP2(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 2C(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1D(gene name synonym)|uniprotkb:SH-PTP3(gene name synonym)|uniprotkb:SH-PTP2(gene name synonym)	psi-mi:irs1_human(display_long)|uniprotkb:IRS1(gene name)|psi-mi:IRS1(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Sugimoto et al. (1994)	mint:MINT-6672794|pubmed:7513703	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8560679|mint:MINT-8032601	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:5I6V|rcsb pdb:5IBM|rcsb pdb:5IBS|rcsb pdb:5X7B|rcsb pdb:5X94|rcsb pdb:5XZR|rcsb pdb:6ATD|rcsb pdb:6BMR|rcsb pdb:6BMU|rcsb pdb:6BMV|rcsb pdb:6BMW|rcsb pdb:6BMX|rcsb pdb:6BMY|rcsb pdb:6BN5|rcsb pdb:6CMP|rcsb pdb:6CMQ|rcsb pdb:6CMR|rcsb pdb:6CMS|rcsb pdb:6CRF|rcsb pdb:6CRG|rcsb pdb:6MD7|rcsb pdb:6MD9|rcsb pdb:6MDA|rcsb pdb:6MDB|rcsb pdb:6MDC|rcsb pdb:6MDD|rcsb pdb:6R5G|rcsb pdb:6WU8|rcsb pdb:7EMN|rcsb pdb:7JVM|rcsb pdb:7JVN|reactome:R-HSA-1059683|reactome:R-HSA-109704|reactome:R-HSA-110056|reactome:R-HSA-112411|rcsb pdb:5EHR|reactome:R-HSA-114604|reactome:R-HSA-1170546|reactome:R-HSA-512988|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-1257604|reactome:R-HSA-5654695|reactome:R-HSA-5654700|reactome:R-HSA-1295596|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-1433557|reactome:R-HSA-180292|reactome:R-HSA-5654733|reactome:R-HSA-186763|reactome:R-HSA-6811558|reactome:R-HSA-210990|reactome:R-HSA-210993|reactome:R-HSA-877312|reactome:R-HSA-8853659|reactome:R-HSA-8854691|reactome:R-HSA-8865999|reactome:R-HSA-8934593|reactome:R-HSA-9008059|reactome:R-HSA-2219530|reactome:R-HSA-2586552|reactome:R-HSA-388841|reactome:R-HSA-389513|reactome:R-HSA-9028731|reactome:R-HSA-389948|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-391160|reactome:R-HSA-936964|reactome:R-HSA-418886|reactome:R-HSA-432142|reactome:R-HSA-9607240|reactome:R-HSA-9645135|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703648|ensembl:ENSG00000179295(gene)|ensembl:ENST00000351677(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030220"(platelet formation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032528"(microvillus organization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035265"(organ growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048609"(multicellular organismal reproductive process)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0048806"(genitalia development)|go:"GO:0048839"(inner ear development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051463"(negative regulation of cortisol secretion)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0061582"(intestinal epithelial cell migration)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|rcsb pdb:3ZM0|rcsb pdb:3ZM1|rcsb pdb:3ZM2|rcsb pdb:3ZM3|interpro:IPR029021|rcsb pdb:4DGP|rcsb pdb:4DGX|interpro:IPR036860|mint:Q06124|rcsb pdb:4GWF|rcsb pdb:4H1O|rcsb pdb:4H34|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4JMG|rcsb pdb:4NWF|rcsb pdb:4NWG|rcsb pdb:4OHD|rcsb pdb:4OHE|rcsb pdb:4OHH|rcsb pdb:4OHI|rcsb pdb:4OHL|rcsb pdb:2SHP|rcsb pdb:3B7O|rcsb pdb:3MOW|rcsb pdb:3O5X|rcsb pdb:3TKZ|rcsb pdb:3TL0|rcsb pdb:4PVG|rcsb pdb:4QSY|rcsb pdb:4RDD|rcsb pdb:5BK8|rcsb pdb:5DF6|rcsb pdb:5EHP|refseq:NP_002825.3|refseq:NP_542168.1|refseq:NP_001317366.1|dip:DIP-516N|mint:MINT-8032602(identity)|uniprotkb:Q06124(original identifier)	refseq:NP_005535.1|ensembl:ENSP00000304895|dip:DIP-523N|ensembl:ENSG00000169047(gene)|ensembl:ENST00000305123(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0071398"(cellular response to fatty acid)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|mint:P35568|rcsb pdb:1IRS|rcsb pdb:1K3A|rcsb pdb:1QQG|rcsb pdb:2Z8C|rcsb pdb:5U1M|rcsb pdb:6BNT|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-112412|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-2219530|reactome:R-HSA-2428928|reactome:R-HSA-2586552|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-9603381|reactome:R-HSA-982772|mint:MINT-8032605(identity)|uniprotkb:P35568(original identifier)	-	-	-	comment:homomint|comment:mint|partial coverage:partial coverage	taxid:-3(unknown)|taxid:-3(Unknown)	-	2010/09/28	2020/01/07	rogid:I1qRE/L3Wi7q+l/n0NnjKRQ5vqU9606	rogid:n/9Epczwu5jOLSKCKhmIgR7CdOw9606	intact-crc:571EA204E0872E3D|rigid:E6RxY8r5ATzcXuSzxqQo7OZrU3Q	false	-	binding-associated region:1172-1185(MINT-8032608)|phosphorylated residue:1179-1179(MINT-8032610)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q06124	uniprotkb:P35568	intact:EBI-297779|uniprotkb:Q96HD7|ensembl:ENSP00000340944|uniprotkb:A8K1D9|intact:EBI-14351608|intact:EBI-11988773|intact:EBI-13004965	intact:EBI-517592|intact:EBI-28983786|ensembl:ENSP00000304895	psi-mi:ptn11_human(display_long)|uniprotkb:PTPN11(gene name)|psi-mi:PTPN11(display_short)|uniprotkb:PTP2C(gene name synonym)|uniprotkb:SHPTP2(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 2C(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1D(gene name synonym)|uniprotkb:SH-PTP3(gene name synonym)|uniprotkb:SH-PTP2(gene name synonym)	psi-mi:irs1_human(display_long)|uniprotkb:IRS1(gene name)|psi-mi:IRS1(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Sugimoto et al. (1994)	mint:MINT-6672794|pubmed:7513703	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8560715|mint:MINT-8037305	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:5I6V|rcsb pdb:5IBM|rcsb pdb:5IBS|rcsb pdb:5X7B|rcsb pdb:5X94|rcsb pdb:5XZR|rcsb pdb:6ATD|rcsb pdb:6BMR|rcsb pdb:6BMU|rcsb pdb:6BMV|rcsb pdb:6BMW|rcsb pdb:6BMX|rcsb pdb:6BMY|rcsb pdb:6BN5|rcsb pdb:6CMP|rcsb pdb:6CMQ|rcsb pdb:6CMR|rcsb pdb:6CMS|rcsb pdb:6CRF|rcsb pdb:6CRG|rcsb pdb:6MD7|rcsb pdb:6MD9|rcsb pdb:6MDA|rcsb pdb:6MDB|rcsb pdb:6MDC|rcsb pdb:6MDD|rcsb pdb:6R5G|rcsb pdb:6WU8|rcsb pdb:7EMN|rcsb pdb:7JVM|rcsb pdb:7JVN|reactome:R-HSA-1059683|reactome:R-HSA-109704|reactome:R-HSA-110056|reactome:R-HSA-112411|rcsb pdb:5EHR|reactome:R-HSA-114604|reactome:R-HSA-1170546|reactome:R-HSA-512988|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-1257604|reactome:R-HSA-5654695|reactome:R-HSA-5654700|reactome:R-HSA-1295596|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-1433557|reactome:R-HSA-180292|reactome:R-HSA-5654733|reactome:R-HSA-186763|reactome:R-HSA-6811558|reactome:R-HSA-210990|reactome:R-HSA-210993|reactome:R-HSA-877312|reactome:R-HSA-8853659|reactome:R-HSA-8854691|reactome:R-HSA-8865999|reactome:R-HSA-8934593|reactome:R-HSA-9008059|reactome:R-HSA-2219530|reactome:R-HSA-2586552|reactome:R-HSA-388841|reactome:R-HSA-389513|reactome:R-HSA-9028731|reactome:R-HSA-389948|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-391160|reactome:R-HSA-936964|reactome:R-HSA-418886|reactome:R-HSA-432142|reactome:R-HSA-9607240|reactome:R-HSA-9645135|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703648|ensembl:ENSG00000179295(gene)|ensembl:ENST00000351677(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030220"(platelet formation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032528"(microvillus organization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035265"(organ growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048609"(multicellular organismal reproductive process)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0048806"(genitalia development)|go:"GO:0048839"(inner ear development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051463"(negative regulation of cortisol secretion)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0061582"(intestinal epithelial cell migration)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|rcsb pdb:3ZM0|rcsb pdb:3ZM1|rcsb pdb:3ZM2|rcsb pdb:3ZM3|interpro:IPR029021|rcsb pdb:4DGP|rcsb pdb:4DGX|interpro:IPR036860|mint:Q06124|rcsb pdb:4GWF|rcsb pdb:4H1O|rcsb pdb:4H34|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4JMG|rcsb pdb:4NWF|rcsb pdb:4NWG|rcsb pdb:4OHD|rcsb pdb:4OHE|rcsb pdb:4OHH|rcsb pdb:4OHI|rcsb pdb:4OHL|rcsb pdb:2SHP|rcsb pdb:3B7O|rcsb pdb:3MOW|rcsb pdb:3O5X|rcsb pdb:3TKZ|rcsb pdb:3TL0|rcsb pdb:4PVG|rcsb pdb:4QSY|rcsb pdb:4RDD|rcsb pdb:5BK8|rcsb pdb:5DF6|rcsb pdb:5EHP|refseq:NP_002825.3|refseq:NP_542168.1|refseq:NP_001317366.1|dip:DIP-516N|mint:MINT-8037306(identity)|uniprotkb:Q06124(original identifier)	refseq:NP_005535.1|ensembl:ENSP00000304895|dip:DIP-523N|ensembl:ENSG00000169047(gene)|ensembl:ENST00000305123(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0071398"(cellular response to fatty acid)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|mint:P35568|rcsb pdb:1IRS|rcsb pdb:1K3A|rcsb pdb:1QQG|rcsb pdb:2Z8C|rcsb pdb:5U1M|rcsb pdb:6BNT|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-112412|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-2219530|reactome:R-HSA-2428928|reactome:R-HSA-2586552|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-9603381|reactome:R-HSA-982772|mint:MINT-8037309(identity)|uniprotkb:P35568(original identifier)	-	-	-	comment:homomint|comment:mint|partial coverage:partial coverage	taxid:-3(unknown)|taxid:-3(Unknown)	-	2010/09/28	2020/01/07	rogid:I1qRE/L3Wi7q+l/n0NnjKRQ5vqU9606	rogid:n/9Epczwu5jOLSKCKhmIgR7CdOw9606	intact-crc:15D39914E32B9BE3|rigid:E6RxY8r5ATzcXuSzxqQo7OZrU3Q	false	-	phosphorylated residue:1229-1229(MINT-8037314)|binding-associated region:1222-1235(MINT-8037312)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35568	uniprotkb:Q06124	intact:EBI-517592|intact:EBI-28983786|ensembl:ENSP00000304895	intact:EBI-297779|uniprotkb:Q96HD7|ensembl:ENSP00000340944|uniprotkb:A8K1D9|intact:EBI-14351608|intact:EBI-11988773|intact:EBI-13004965	psi-mi:irs1_human(display_long)|uniprotkb:IRS1(gene name)|psi-mi:IRS1(display_short)	psi-mi:ptn11_human(display_long)|uniprotkb:PTPN11(gene name)|psi-mi:PTPN11(display_short)|uniprotkb:PTP2C(gene name synonym)|uniprotkb:SHPTP2(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 2C(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1D(gene name synonym)|uniprotkb:SH-PTP3(gene name synonym)|uniprotkb:SH-PTP2(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Sugimoto et al. (1994)	mint:MINT-6672794|pubmed:7513703	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8560697|mint:MINT-8035069	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005535.1|ensembl:ENSP00000304895|dip:DIP-523N|ensembl:ENSG00000169047(gene)|ensembl:ENST00000305123(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0071398"(cellular response to fatty acid)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|mint:P35568|rcsb pdb:1IRS|rcsb pdb:1K3A|rcsb pdb:1QQG|rcsb pdb:2Z8C|rcsb pdb:5U1M|rcsb pdb:6BNT|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-112412|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-2219530|reactome:R-HSA-2428928|reactome:R-HSA-2586552|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-9603381|reactome:R-HSA-982772|mint:MINT-8035073(identity)|uniprotkb:P35568(original identifier)	rcsb pdb:5I6V|rcsb pdb:5IBM|rcsb pdb:5IBS|rcsb pdb:5X7B|rcsb pdb:5X94|rcsb pdb:5XZR|rcsb pdb:6ATD|rcsb pdb:6BMR|rcsb pdb:6BMU|rcsb pdb:6BMV|rcsb pdb:6BMW|rcsb pdb:6BMX|rcsb pdb:6BMY|rcsb pdb:6BN5|rcsb pdb:6CMP|rcsb pdb:6CMQ|rcsb pdb:6CMR|rcsb pdb:6CMS|rcsb pdb:6CRF|rcsb pdb:6CRG|rcsb pdb:6MD7|rcsb pdb:6MD9|rcsb pdb:6MDA|rcsb pdb:6MDB|rcsb pdb:6MDC|rcsb pdb:6MDD|rcsb pdb:6R5G|rcsb pdb:6WU8|rcsb pdb:7EMN|rcsb pdb:7JVM|rcsb pdb:7JVN|reactome:R-HSA-1059683|reactome:R-HSA-109704|reactome:R-HSA-110056|reactome:R-HSA-112411|rcsb pdb:5EHR|reactome:R-HSA-114604|reactome:R-HSA-1170546|reactome:R-HSA-512988|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-1257604|reactome:R-HSA-5654695|reactome:R-HSA-5654700|reactome:R-HSA-1295596|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-1433557|reactome:R-HSA-180292|reactome:R-HSA-5654733|reactome:R-HSA-186763|reactome:R-HSA-6811558|reactome:R-HSA-210990|reactome:R-HSA-210993|reactome:R-HSA-877312|reactome:R-HSA-8853659|reactome:R-HSA-8854691|reactome:R-HSA-8865999|reactome:R-HSA-8934593|reactome:R-HSA-9008059|reactome:R-HSA-2219530|reactome:R-HSA-2586552|reactome:R-HSA-388841|reactome:R-HSA-389513|reactome:R-HSA-9028731|reactome:R-HSA-389948|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-391160|reactome:R-HSA-936964|reactome:R-HSA-418886|reactome:R-HSA-432142|reactome:R-HSA-9607240|reactome:R-HSA-9645135|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703648|ensembl:ENSG00000179295(gene)|ensembl:ENST00000351677(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030220"(platelet formation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032528"(microvillus organization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035265"(organ growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048609"(multicellular organismal reproductive process)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0048806"(genitalia development)|go:"GO:0048839"(inner ear development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051463"(negative regulation of cortisol secretion)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0061582"(intestinal epithelial cell migration)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|rcsb pdb:3ZM0|rcsb pdb:3ZM1|rcsb pdb:3ZM2|rcsb pdb:3ZM3|interpro:IPR029021|rcsb pdb:4DGP|rcsb pdb:4DGX|interpro:IPR036860|mint:Q06124|rcsb pdb:4GWF|rcsb pdb:4H1O|rcsb pdb:4H34|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4JMG|rcsb pdb:4NWF|rcsb pdb:4NWG|rcsb pdb:4OHD|rcsb pdb:4OHE|rcsb pdb:4OHH|rcsb pdb:4OHI|rcsb pdb:4OHL|rcsb pdb:2SHP|rcsb pdb:3B7O|rcsb pdb:3MOW|rcsb pdb:3O5X|rcsb pdb:3TKZ|rcsb pdb:3TL0|rcsb pdb:4PVG|rcsb pdb:4QSY|rcsb pdb:4RDD|rcsb pdb:5BK8|rcsb pdb:5DF6|rcsb pdb:5EHP|refseq:NP_002825.3|refseq:NP_542168.1|refseq:NP_001317366.1|dip:DIP-516N|mint:MINT-8035070(identity)|uniprotkb:Q06124(original identifier)	-	-	-	comment:homomint|comment:mint|partial coverage:partial coverage	taxid:-3(unknown)|taxid:-3(Unknown)	-	2010/09/28	2020/01/07	rogid:n/9Epczwu5jOLSKCKhmIgR7CdOw9606	rogid:I1qRE/L3Wi7q+l/n0NnjKRQ5vqU9606	intact-crc:B541575BEDAD6851|rigid:E6RxY8r5ATzcXuSzxqQo7OZrU3Q	false	phosphorylated residue:896-896(MINT-8035078)|binding-associated region:889-902(MINT-8035076)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)