#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P22681	uniprotkb:P08581	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	intact:EBI-1039152|uniprotkb:O60366|uniprotkb:Q12875|uniprotkb:Q9UDX7|uniprotkb:Q9UPL8|uniprotkb:A1L467|uniprotkb:B5A932|uniprotkb:E7EQ94|ensembl:ENSP00000380860	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:met_human(display_long)|uniprotkb:MET(gene name)|psi-mi:MET(display_short)|uniprotkb:Scatter factor receptor(gene name synonym)|uniprotkb:HGF/SF receptor(gene name synonym)|uniprotkb:Tyrosine-protein kinase Met(gene name synonym)|uniprotkb:Proto-oncogene c-Met(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Sun et al. (2011)	mint:MINT-8076605|pubmed:21163258|doi:10.1016/j.febslet.2010.11.060|mint:d-10-01881	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8546473|mint:MINT-8076662	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|mint:MINT-8076665(identity)	refseq:NP_000236.2|refseq:NP_001120972.1|rcsb pdb:2UZY|rcsb pdb:2WD1|rcsb pdb:2WGJ|rcsb pdb:2WKM|rcsb pdb:3A4P|rcsb pdb:3BUX|rcsb pdb:3C1X|rcsb pdb:3CCN|rcsb pdb:3CD8|rcsb pdb:3CE3|rcsb pdb:3CTH|rcsb pdb:3CTJ|rcsb pdb:3DKC|rcsb pdb:3DKF|rcsb pdb:3DKG|rcsb pdb:3EFJ|rcsb pdb:3EFK|rcsb pdb:3F66|rcsb pdb:3F82|rcsb pdb:3U6H|rcsb pdb:3I5N|rcsb pdb:3L8V|rcsb pdb:3LQ8|rcsb pdb:3Q6U|rcsb pdb:3Q6W|rcsb pdb:3QTI|rcsb pdb:3R7O|rcsb pdb:3RHK|go:"GO:0043235"(receptor complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|ensembl:ENSG00000105976(gene)|ensembl:ENST00000397752(transcript)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0005008"(hepatocyte growth factor-activated receptor activity)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0005524"(ATP binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:1901299"(negative regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|interpro:IPR002909(Cell surface receptor IPT/TIG)|go:"GO:0006909"(phagocytosis)|go:"GO:0007165"(signal transduction)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010507"(negative regulation of autophagy)|interpro:IPR011009(Protein kinase-like)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019903"(protein phosphatase binding)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031016"(pancreas development)|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0031116"(positive regulation of microtubule polymerization)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|interpro:IPR016201(Plexin-like fold)|interpro:IPR016244(Tyrosine-protein kinase, HGF/MSP receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR031148|interpro:IPR036352|mint:P08581|rcsb pdb:1FYR|rcsb pdb:1R0P|rcsb pdb:1R1W|rcsb pdb:1SHY|rcsb pdb:1SSL|rcsb pdb:1UX3|rcsb pdb:2G15|rcsb pdb:2RFN|rcsb pdb:2RFS|rcsb pdb:2UZX|rcsb pdb:3VW8|rcsb pdb:3ZBX|rcsb pdb:3ZC5|rcsb pdb:3ZCL|rcsb pdb:3U6I|rcsb pdb:3ZXZ|rcsb pdb:3ZZE|rcsb pdb:4AOI|rcsb pdb:4AP7|rcsb pdb:4DEG|rcsb pdb:4DEH|rcsb pdb:4DEI|rcsb pdb:4EEV|rcsb pdb:4GG5|rcsb pdb:4GG7|rcsb pdb:4IWD|rcsb pdb:4K3J|rcsb pdb:4KNB|rcsb pdb:4MXC|rcsb pdb:4O3T|rcsb pdb:4O3U|rcsb pdb:4R1V|rcsb pdb:4R1Y|rcsb pdb:4XMO|rcsb pdb:4XYF|rcsb pdb:5DG5|rcsb pdb:5EOB|rcsb pdb:5EYC|rcsb pdb:5EYD|rcsb pdb:5HLW|rcsb pdb:5HNI|rcsb pdb:5HO6|rcsb pdb:5HOA|rcsb pdb:5HOR|rcsb pdb:5HTI|rcsb pdb:5LSP|rcsb pdb:5T3Q|rcsb pdb:5UAB|rcsb pdb:5UAD|rcsb pdb:5YA5|rcsb pdb:6GCU|rcsb pdb:6I04|rcsb pdb:6SD9|rcsb pdb:6SDC|rcsb pdb:6SDD|rcsb pdb:6SDE|rcsb pdb:6UBW|rcsb pdb:6WVZ|rcsb pdb:7B3Q|rcsb pdb:7B3T|rcsb pdb:7B3V|rcsb pdb:7B3W|rcsb pdb:7B3Z|rcsb pdb:7B40|rcsb pdb:7B41|rcsb pdb:7B42|rcsb pdb:7B43|rcsb pdb:7B44|rcsb pdb:7MO8|rcsb pdb:7MO9|rcsb pdb:7MOA|rcsb pdb:7MOB|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-416550|reactome:R-HSA-5673001|reactome:R-HSA-6806942|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8865999|reactome:R-HSA-8874081|reactome:R-HSA-8875360|rcsb pdb:7MO7|reactome:R-HSA-8875513|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8875791|reactome:R-HSA-9022699|dip:DIP-6023N|mint:MINT-8076669(identity)	-	-	-	comment:homomint|comment:mint|figure legend:t2 f2 f3	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/12/01	2014/10/16	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	rogid:Xhr+H4h5JjKYOhEqtgK7PNh1brs9606	intact-crc:D2945B78B7FAA51D|rigid:3JTwY9G/pPlPsmIHrZwiRGsBsog	false	binding-associated region:2-351(MINT-8076666)	mutation decreasing interaction:1004-1004(MINT-8076672)|mutation decreasing interaction:1002-1002(MINT-8076674)|phosphorylated residue:1003-1003(MINT-8076670)|binding-associated region:997-1009(MINT-8076676)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:P08581	uniprotkb:P22681	intact:EBI-1039152|uniprotkb:O60366|uniprotkb:Q12875|uniprotkb:Q9UDX7|uniprotkb:Q9UPL8|uniprotkb:A1L467|uniprotkb:B5A932|uniprotkb:E7EQ94|ensembl:ENSP00000380860	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	psi-mi:met_human(display_long)|uniprotkb:MET(gene name)|psi-mi:MET(display_short)|uniprotkb:Scatter factor receptor(gene name synonym)|uniprotkb:HGF/SF receptor(gene name synonym)|uniprotkb:Tyrosine-protein kinase Met(gene name synonym)|uniprotkb:Proto-oncogene c-Met(gene name synonym)	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Sun et al. (2011)	mint:MINT-8076605|pubmed:21163258|doi:10.1016/j.febslet.2010.11.060|mint:d-10-01881	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8546510|mint:MINT-8076616	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000236.2|refseq:NP_001120972.1|rcsb pdb:2UZY|rcsb pdb:2WD1|rcsb pdb:2WGJ|rcsb pdb:2WKM|rcsb pdb:3A4P|rcsb pdb:3BUX|rcsb pdb:3C1X|rcsb pdb:3CCN|rcsb pdb:3CD8|rcsb pdb:3CE3|rcsb pdb:3CTH|rcsb pdb:3CTJ|rcsb pdb:3DKC|rcsb pdb:3DKF|rcsb pdb:3DKG|rcsb pdb:3EFJ|rcsb pdb:3EFK|rcsb pdb:3F66|rcsb pdb:3F82|rcsb pdb:3U6H|rcsb pdb:3I5N|rcsb pdb:3L8V|rcsb pdb:3LQ8|rcsb pdb:3Q6U|rcsb pdb:3Q6W|rcsb pdb:3QTI|rcsb pdb:3R7O|rcsb pdb:3RHK|go:"GO:0043235"(receptor complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|ensembl:ENSG00000105976(gene)|ensembl:ENST00000397752(transcript)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0005008"(hepatocyte growth factor-activated receptor activity)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0005524"(ATP binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:1901299"(negative regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|interpro:IPR002909(Cell surface receptor IPT/TIG)|go:"GO:0006909"(phagocytosis)|go:"GO:0007165"(signal transduction)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010507"(negative regulation of autophagy)|interpro:IPR011009(Protein kinase-like)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019903"(protein phosphatase binding)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031016"(pancreas development)|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0031116"(positive regulation of microtubule polymerization)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|interpro:IPR016201(Plexin-like fold)|interpro:IPR016244(Tyrosine-protein kinase, HGF/MSP receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR031148|interpro:IPR036352|mint:P08581|rcsb pdb:1FYR|rcsb pdb:1R0P|rcsb pdb:1R1W|rcsb pdb:1SHY|rcsb pdb:1SSL|rcsb pdb:1UX3|rcsb pdb:2G15|rcsb pdb:2RFN|rcsb pdb:2RFS|rcsb pdb:2UZX|rcsb pdb:3VW8|rcsb pdb:3ZBX|rcsb pdb:3ZC5|rcsb pdb:3ZCL|rcsb pdb:3U6I|rcsb pdb:3ZXZ|rcsb pdb:3ZZE|rcsb pdb:4AOI|rcsb pdb:4AP7|rcsb pdb:4DEG|rcsb pdb:4DEH|rcsb pdb:4DEI|rcsb pdb:4EEV|rcsb pdb:4GG5|rcsb pdb:4GG7|rcsb pdb:4IWD|rcsb pdb:4K3J|rcsb pdb:4KNB|rcsb pdb:4MXC|rcsb pdb:4O3T|rcsb pdb:4O3U|rcsb pdb:4R1V|rcsb pdb:4R1Y|rcsb pdb:4XMO|rcsb pdb:4XYF|rcsb pdb:5DG5|rcsb pdb:5EOB|rcsb pdb:5EYC|rcsb pdb:5EYD|rcsb pdb:5HLW|rcsb pdb:5HNI|rcsb pdb:5HO6|rcsb pdb:5HOA|rcsb pdb:5HOR|rcsb pdb:5HTI|rcsb pdb:5LSP|rcsb pdb:5T3Q|rcsb pdb:5UAB|rcsb pdb:5UAD|rcsb pdb:5YA5|rcsb pdb:6GCU|rcsb pdb:6I04|rcsb pdb:6SD9|rcsb pdb:6SDC|rcsb pdb:6SDD|rcsb pdb:6SDE|rcsb pdb:6UBW|rcsb pdb:6WVZ|rcsb pdb:7B3Q|rcsb pdb:7B3T|rcsb pdb:7B3V|rcsb pdb:7B3W|rcsb pdb:7B3Z|rcsb pdb:7B40|rcsb pdb:7B41|rcsb pdb:7B42|rcsb pdb:7B43|rcsb pdb:7B44|rcsb pdb:7MO8|rcsb pdb:7MO9|rcsb pdb:7MOA|rcsb pdb:7MOB|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-416550|reactome:R-HSA-5673001|reactome:R-HSA-6806942|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8865999|reactome:R-HSA-8874081|reactome:R-HSA-8875360|rcsb pdb:7MO7|reactome:R-HSA-8875513|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8875791|reactome:R-HSA-9022699|dip:DIP-6023N|mint:MINT-8076619(identity)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|mint:MINT-8076618(identity)	-	-	-	comment:homomint|comment:mint|figure legend:t1 f1	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.4x10^-6(molar)	2010/12/01	2014/10/16	rogid:Xhr+H4h5JjKYOhEqtgK7PNh1brs9606	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	intact-crc:E8D5556C058B24B6|rigid:3JTwY9G/pPlPsmIHrZwiRGsBsog	false	binding-associated region:997-1009(MINT-8076627)|phosphorylated residue:1003-1003(MINT-8076659)|mutation disrupting interaction:1005-1005(MINT-8076632)|mutation disrupting interaction:1004-1004(MINT-8076629)	binding-associated region:2-351(MINT-8076623)	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22681	uniprotkb:P08581	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	intact:EBI-1039152|uniprotkb:O60366|uniprotkb:Q12875|uniprotkb:Q9UDX7|uniprotkb:Q9UPL8|uniprotkb:A1L467|uniprotkb:B5A932|uniprotkb:E7EQ94|ensembl:ENSP00000380860	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:met_human(display_long)|uniprotkb:MET(gene name)|psi-mi:MET(display_short)|uniprotkb:Scatter factor receptor(gene name synonym)|uniprotkb:HGF/SF receptor(gene name synonym)|uniprotkb:Tyrosine-protein kinase Met(gene name synonym)|uniprotkb:Proto-oncogene c-Met(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Sun et al. (2011)	mint:MINT-8076605|pubmed:21163258|doi:10.1016/j.febslet.2010.11.060|mint:d-10-01881	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8546546|mint:MINT-8076636	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|mint:MINT-8076639(identity)	refseq:NP_000236.2|refseq:NP_001120972.1|rcsb pdb:2UZY|rcsb pdb:2WD1|rcsb pdb:2WGJ|rcsb pdb:2WKM|rcsb pdb:3A4P|rcsb pdb:3BUX|rcsb pdb:3C1X|rcsb pdb:3CCN|rcsb pdb:3CD8|rcsb pdb:3CE3|rcsb pdb:3CTH|rcsb pdb:3CTJ|rcsb pdb:3DKC|rcsb pdb:3DKF|rcsb pdb:3DKG|rcsb pdb:3EFJ|rcsb pdb:3EFK|rcsb pdb:3F66|rcsb pdb:3F82|rcsb pdb:3U6H|rcsb pdb:3I5N|rcsb pdb:3L8V|rcsb pdb:3LQ8|rcsb pdb:3Q6U|rcsb pdb:3Q6W|rcsb pdb:3QTI|rcsb pdb:3R7O|rcsb pdb:3RHK|go:"GO:0043235"(receptor complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|ensembl:ENSG00000105976(gene)|ensembl:ENST00000397752(transcript)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0005008"(hepatocyte growth factor-activated receptor activity)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0005524"(ATP binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:1901299"(negative regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|interpro:IPR002909(Cell surface receptor IPT/TIG)|go:"GO:0006909"(phagocytosis)|go:"GO:0007165"(signal transduction)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010507"(negative regulation of autophagy)|interpro:IPR011009(Protein kinase-like)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019903"(protein phosphatase binding)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031016"(pancreas development)|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0031116"(positive regulation of microtubule polymerization)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|interpro:IPR016201(Plexin-like fold)|interpro:IPR016244(Tyrosine-protein kinase, HGF/MSP receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR031148|interpro:IPR036352|mint:P08581|rcsb pdb:1FYR|rcsb pdb:1R0P|rcsb pdb:1R1W|rcsb pdb:1SHY|rcsb pdb:1SSL|rcsb pdb:1UX3|rcsb pdb:2G15|rcsb pdb:2RFN|rcsb pdb:2RFS|rcsb pdb:2UZX|rcsb pdb:3VW8|rcsb pdb:3ZBX|rcsb pdb:3ZC5|rcsb pdb:3ZCL|rcsb pdb:3U6I|rcsb pdb:3ZXZ|rcsb pdb:3ZZE|rcsb pdb:4AOI|rcsb pdb:4AP7|rcsb pdb:4DEG|rcsb pdb:4DEH|rcsb pdb:4DEI|rcsb pdb:4EEV|rcsb pdb:4GG5|rcsb pdb:4GG7|rcsb pdb:4IWD|rcsb pdb:4K3J|rcsb pdb:4KNB|rcsb pdb:4MXC|rcsb pdb:4O3T|rcsb pdb:4O3U|rcsb pdb:4R1V|rcsb pdb:4R1Y|rcsb pdb:4XMO|rcsb pdb:4XYF|rcsb pdb:5DG5|rcsb pdb:5EOB|rcsb pdb:5EYC|rcsb pdb:5EYD|rcsb pdb:5HLW|rcsb pdb:5HNI|rcsb pdb:5HO6|rcsb pdb:5HOA|rcsb pdb:5HOR|rcsb pdb:5HTI|rcsb pdb:5LSP|rcsb pdb:5T3Q|rcsb pdb:5UAB|rcsb pdb:5UAD|rcsb pdb:5YA5|rcsb pdb:6GCU|rcsb pdb:6I04|rcsb pdb:6SD9|rcsb pdb:6SDC|rcsb pdb:6SDD|rcsb pdb:6SDE|rcsb pdb:6UBW|rcsb pdb:6WVZ|rcsb pdb:7B3Q|rcsb pdb:7B3T|rcsb pdb:7B3V|rcsb pdb:7B3W|rcsb pdb:7B3Z|rcsb pdb:7B40|rcsb pdb:7B41|rcsb pdb:7B42|rcsb pdb:7B43|rcsb pdb:7B44|rcsb pdb:7MO8|rcsb pdb:7MO9|rcsb pdb:7MOA|rcsb pdb:7MOB|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-416550|reactome:R-HSA-5673001|reactome:R-HSA-6806942|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8865999|reactome:R-HSA-8874081|reactome:R-HSA-8875360|rcsb pdb:7MO7|reactome:R-HSA-8875513|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8875791|reactome:R-HSA-9022699|dip:DIP-6023N|mint:MINT-8076643(identity)	-	-	-	comment:homomint|comment:mint|figure legend:t1 f1	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:6.7x10^-6(molar)	2010/12/01	2014/10/16	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	rogid:Xhr+H4h5JjKYOhEqtgK7PNh1brs9606	intact-crc:96876E9765ACB19A|rigid:3JTwY9G/pPlPsmIHrZwiRGsBsog	false	binding-associated region:2-351(MINT-8076640)	binding-associated region:997-1009(MINT-8076648)|mutation decreasing interaction:1004-1004(MINT-8076646)|phosphorylated residue:1003-1003(MINT-8076653)|mutation decreasing interaction:1002-1002(MINT-8076644)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:P08581	uniprotkb:P22681	intact:EBI-1039152|uniprotkb:O60366|uniprotkb:Q12875|uniprotkb:Q9UDX7|uniprotkb:Q9UPL8|uniprotkb:A1L467|uniprotkb:B5A932|uniprotkb:E7EQ94|ensembl:ENSP00000380860	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	psi-mi:met_human(display_long)|uniprotkb:MET(gene name)|psi-mi:MET(display_short)|uniprotkb:Scatter factor receptor(gene name synonym)|uniprotkb:HGF/SF receptor(gene name synonym)|uniprotkb:Tyrosine-protein kinase Met(gene name synonym)|uniprotkb:Proto-oncogene c-Met(gene name synonym)	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:"MI:0069"(mass spectrometry studies of complexes)	Sun et al. (2011)	mint:MINT-8076605|pubmed:21163258|doi:10.1016/j.febslet.2010.11.060|mint:d-10-01881	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8546666|mint:MINT-8076689	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000236.2|refseq:NP_001120972.1|rcsb pdb:2UZY|rcsb pdb:2WD1|rcsb pdb:2WGJ|rcsb pdb:2WKM|rcsb pdb:3A4P|rcsb pdb:3BUX|rcsb pdb:3C1X|rcsb pdb:3CCN|rcsb pdb:3CD8|rcsb pdb:3CE3|rcsb pdb:3CTH|rcsb pdb:3CTJ|rcsb pdb:3DKC|rcsb pdb:3DKF|rcsb pdb:3DKG|rcsb pdb:3EFJ|rcsb pdb:3EFK|rcsb pdb:3F66|rcsb pdb:3F82|rcsb pdb:3U6H|rcsb pdb:3I5N|rcsb pdb:3L8V|rcsb pdb:3LQ8|rcsb pdb:3Q6U|rcsb pdb:3Q6W|rcsb pdb:3QTI|rcsb pdb:3R7O|rcsb pdb:3RHK|go:"GO:0043235"(receptor complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|ensembl:ENSG00000105976(gene)|ensembl:ENST00000397752(transcript)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0005008"(hepatocyte growth factor-activated receptor activity)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0005524"(ATP binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:1901299"(negative regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|interpro:IPR002909(Cell surface receptor IPT/TIG)|go:"GO:0006909"(phagocytosis)|go:"GO:0007165"(signal transduction)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010507"(negative regulation of autophagy)|interpro:IPR011009(Protein kinase-like)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019903"(protein phosphatase binding)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031016"(pancreas development)|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0031116"(positive regulation of microtubule polymerization)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|interpro:IPR016201(Plexin-like fold)|interpro:IPR016244(Tyrosine-protein kinase, HGF/MSP receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR031148|interpro:IPR036352|mint:P08581|rcsb pdb:1FYR|rcsb pdb:1R0P|rcsb pdb:1R1W|rcsb pdb:1SHY|rcsb pdb:1SSL|rcsb pdb:1UX3|rcsb pdb:2G15|rcsb pdb:2RFN|rcsb pdb:2RFS|rcsb pdb:2UZX|rcsb pdb:3VW8|rcsb pdb:3ZBX|rcsb pdb:3ZC5|rcsb pdb:3ZCL|rcsb pdb:3U6I|rcsb pdb:3ZXZ|rcsb pdb:3ZZE|rcsb pdb:4AOI|rcsb pdb:4AP7|rcsb pdb:4DEG|rcsb pdb:4DEH|rcsb pdb:4DEI|rcsb pdb:4EEV|rcsb pdb:4GG5|rcsb pdb:4GG7|rcsb pdb:4IWD|rcsb pdb:4K3J|rcsb pdb:4KNB|rcsb pdb:4MXC|rcsb pdb:4O3T|rcsb pdb:4O3U|rcsb pdb:4R1V|rcsb pdb:4R1Y|rcsb pdb:4XMO|rcsb pdb:4XYF|rcsb pdb:5DG5|rcsb pdb:5EOB|rcsb pdb:5EYC|rcsb pdb:5EYD|rcsb pdb:5HLW|rcsb pdb:5HNI|rcsb pdb:5HO6|rcsb pdb:5HOA|rcsb pdb:5HOR|rcsb pdb:5HTI|rcsb pdb:5LSP|rcsb pdb:5T3Q|rcsb pdb:5UAB|rcsb pdb:5UAD|rcsb pdb:5YA5|rcsb pdb:6GCU|rcsb pdb:6I04|rcsb pdb:6SD9|rcsb pdb:6SDC|rcsb pdb:6SDD|rcsb pdb:6SDE|rcsb pdb:6UBW|rcsb pdb:6WVZ|rcsb pdb:7B3Q|rcsb pdb:7B3T|rcsb pdb:7B3V|rcsb pdb:7B3W|rcsb pdb:7B3Z|rcsb pdb:7B40|rcsb pdb:7B41|rcsb pdb:7B42|rcsb pdb:7B43|rcsb pdb:7B44|rcsb pdb:7MO8|rcsb pdb:7MO9|rcsb pdb:7MOA|rcsb pdb:7MOB|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-416550|reactome:R-HSA-5673001|reactome:R-HSA-6806942|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8865999|reactome:R-HSA-8874081|reactome:R-HSA-8875360|rcsb pdb:7MO7|reactome:R-HSA-8875513|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8875791|reactome:R-HSA-9022699|dip:DIP-6023N|mint:MINT-8076695(identity)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|mint:MINT-8076691(identity)	-	-	-	comment:homomint|figure legend:sf1|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/12/01	2014/10/16	rogid:Xhr+H4h5JjKYOhEqtgK7PNh1brs9606	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	intact-crc:DE1B876C1EDE75BD|rigid:3JTwY9G/pPlPsmIHrZwiRGsBsog	false	phosphorylated residue:1003-1003(MINT-8076702)|mutation decreasing interaction:1004-1004(MINT-8076696)|binding-associated region:997-1009(MINT-8076700)|mutation decreasing interaction:1002-1002(MINT-8076698)	binding-associated region:2-351(MINT-8076692)	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0396"(predetermined participant)