#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O75475 uniprotkb:P04585 intact:EBI-1801773|uniprotkb:O00256|uniprotkb:O95368|uniprotkb:Q6P391|uniprotkb:Q86YB9|uniprotkb:Q9NZI3|uniprotkb:Q9UER6|uniprotkb:D3DRI9|ensembl:ENSP00000370109|ensembl:ENSP00000370114 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:psip1_human(display_long)|uniprotkb:PSIP1(gene name)|psi-mi:PSIP1(display_short)|uniprotkb:DFS70(gene name synonym)|uniprotkb:LEDGF(gene name synonym)|uniprotkb:PSIP2(gene name synonym)|uniprotkb:Lens epithelium-derived growth factor(gene name synonym)|uniprotkb:Transcriptional coactivator p75/p52(gene name synonym)|uniprotkb:Dense fine speckles 70 kDa protein(gene name synonym)|uniprotkb:CLL-associated antigen KW-7(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8539578|mint:MINT-8053074 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001304827.1|refseq:NP_001304829.1|refseq:NP_001121689.1|refseq:NP_066967.3|refseq:NP_150091.2|dip:DIP-46656N|ensembl:ENSG00000164985(gene)|ensembl:ENST00000380733(transcript)|ensembl:ENST00000380738(transcript)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009408"(response to heat)|go:"GO:0034399"(nuclear periphery)|go:"GO:0035327"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000313(PWWP)|interpro:IPR021567|interpro:IPR035441|interpro:IPR035496|interpro:IPR036218|mint:O75475|rcsb pdb:1Z9E|rcsb pdb:2B4J|rcsb pdb:2M16|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2N3A|rcsb pdb:3F9K|rcsb pdb:3HPG|rcsb pdb:3HPH|rcsb pdb:3U88|rcsb pdb:3ZEH|rcsb pdb:4FU6|rcsb pdb:5N88|rcsb pdb:5OYM|rcsb pdb:5YI9|rcsb pdb:6EMO|rcsb pdb:6EMP|rcsb pdb:6EMQ|rcsb pdb:6EMR|rcsb pdb:6S01|rcsb pdb:6TRJ|rcsb pdb:6TVM|rcsb pdb:6Z2Y|reactome:R-HSA-162592|reactome:R-HSA-164843|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|mint:MINT-8053086(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053077(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:MRtOw4kH/FxVku25dO5RQiNTjDA9606 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:F8B8D59EEC08BF8D|rigid:8SNUoG3BxkzZIpj6DbpnH/gwuDM false biotin tag:?-?(MINT-8053087)|binding-associated region:401-413(MINT-8053090) polyprotein fragment:1148-1435(MINT-8053080)|binding-associated region:246-260(MINT-8053082) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04585 uniprotkb:O75475 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-1801773|uniprotkb:O00256|uniprotkb:O95368|uniprotkb:Q6P391|uniprotkb:Q86YB9|uniprotkb:Q9NZI3|uniprotkb:Q9UER6|uniprotkb:D3DRI9|ensembl:ENSP00000370109|ensembl:ENSP00000370114 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:psip1_human(display_long)|uniprotkb:PSIP1(gene name)|psi-mi:PSIP1(display_short)|uniprotkb:DFS70(gene name synonym)|uniprotkb:LEDGF(gene name synonym)|uniprotkb:PSIP2(gene name synonym)|uniprotkb:Lens epithelium-derived growth factor(gene name synonym)|uniprotkb:Transcriptional coactivator p75/p52(gene name synonym)|uniprotkb:Dense fine speckles 70 kDa protein(gene name synonym)|uniprotkb:CLL-associated antigen KW-7(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8539619|mint:MINT-8053093 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053095(identity) refseq:NP_001304827.1|refseq:NP_001304829.1|refseq:NP_001121689.1|refseq:NP_066967.3|refseq:NP_150091.2|dip:DIP-46656N|ensembl:ENSG00000164985(gene)|ensembl:ENST00000380733(transcript)|ensembl:ENST00000380738(transcript)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009408"(response to heat)|go:"GO:0034399"(nuclear periphery)|go:"GO:0035327"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000313(PWWP)|interpro:IPR021567|interpro:IPR035441|interpro:IPR035496|interpro:IPR036218|mint:O75475|rcsb pdb:1Z9E|rcsb pdb:2B4J|rcsb pdb:2M16|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2N3A|rcsb pdb:3F9K|rcsb pdb:3HPG|rcsb pdb:3HPH|rcsb pdb:3U88|rcsb pdb:3ZEH|rcsb pdb:4FU6|rcsb pdb:5N88|rcsb pdb:5OYM|rcsb pdb:5YI9|rcsb pdb:6EMO|rcsb pdb:6EMP|rcsb pdb:6EMQ|rcsb pdb:6EMR|rcsb pdb:6S01|rcsb pdb:6TRJ|rcsb pdb:6TVM|rcsb pdb:6Z2Y|reactome:R-HSA-162592|reactome:R-HSA-164843|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|mint:MINT-8053101(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:MRtOw4kH/FxVku25dO5RQiNTjDA9606 intact-crc:2F567D7D186E1E0D|rigid:8SNUoG3BxkzZIpj6DbpnH/gwuDM false binding-associated region:38-52(MINT-8053096)|polyprotein fragment:1148-1435(MINT-8053098) biotin tag:?-?(MINT-8053104)|binding-associated region:401-413(MINT-8053102) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:P04585 uniprotkb:O75475 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-1801773|uniprotkb:O00256|uniprotkb:O95368|uniprotkb:Q6P391|uniprotkb:Q86YB9|uniprotkb:Q9NZI3|uniprotkb:Q9UER6|uniprotkb:D3DRI9|ensembl:ENSP00000370109|ensembl:ENSP00000370114 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:psip1_human(display_long)|uniprotkb:PSIP1(gene name)|psi-mi:PSIP1(display_short)|uniprotkb:DFS70(gene name synonym)|uniprotkb:LEDGF(gene name synonym)|uniprotkb:PSIP2(gene name synonym)|uniprotkb:Lens epithelium-derived growth factor(gene name synonym)|uniprotkb:Transcriptional coactivator p75/p52(gene name synonym)|uniprotkb:Dense fine speckles 70 kDa protein(gene name synonym)|uniprotkb:CLL-associated antigen KW-7(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8539704|mint:MINT-8053135 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053137(identity) refseq:NP_001304827.1|refseq:NP_001304829.1|refseq:NP_001121689.1|refseq:NP_066967.3|refseq:NP_150091.2|dip:DIP-46656N|ensembl:ENSG00000164985(gene)|ensembl:ENST00000380733(transcript)|ensembl:ENST00000380738(transcript)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009408"(response to heat)|go:"GO:0034399"(nuclear periphery)|go:"GO:0035327"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000313(PWWP)|interpro:IPR021567|interpro:IPR035441|interpro:IPR035496|interpro:IPR036218|mint:O75475|rcsb pdb:1Z9E|rcsb pdb:2B4J|rcsb pdb:2M16|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2N3A|rcsb pdb:3F9K|rcsb pdb:3HPG|rcsb pdb:3HPH|rcsb pdb:3U88|rcsb pdb:3ZEH|rcsb pdb:4FU6|rcsb pdb:5N88|rcsb pdb:5OYM|rcsb pdb:5YI9|rcsb pdb:6EMO|rcsb pdb:6EMP|rcsb pdb:6EMQ|rcsb pdb:6EMR|rcsb pdb:6S01|rcsb pdb:6TRJ|rcsb pdb:6TVM|rcsb pdb:6Z2Y|reactome:R-HSA-162592|reactome:R-HSA-164843|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|mint:MINT-8053145(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:MRtOw4kH/FxVku25dO5RQiNTjDA9606 intact-crc:D29FD3B410063D46|rigid:8SNUoG3BxkzZIpj6DbpnH/gwuDM false binding-associated region:182-196(MINT-8053138)|polyprotein fragment:1148-1435(MINT-8053142) biotin tag:?-?(MINT-8053148)|binding-associated region:361-370(MINT-8053146) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:P04585 uniprotkb:O75475 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-1801773|uniprotkb:O00256|uniprotkb:O95368|uniprotkb:Q6P391|uniprotkb:Q86YB9|uniprotkb:Q9NZI3|uniprotkb:Q9UER6|uniprotkb:D3DRI9|ensembl:ENSP00000370109|ensembl:ENSP00000370114 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:psip1_human(display_long)|uniprotkb:PSIP1(gene name)|psi-mi:PSIP1(display_short)|uniprotkb:DFS70(gene name synonym)|uniprotkb:LEDGF(gene name synonym)|uniprotkb:PSIP2(gene name synonym)|uniprotkb:Lens epithelium-derived growth factor(gene name synonym)|uniprotkb:Transcriptional coactivator p75/p52(gene name synonym)|uniprotkb:Dense fine speckles 70 kDa protein(gene name synonym)|uniprotkb:CLL-associated antigen KW-7(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8539642|mint:MINT-8053115 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053117(identity) refseq:NP_001304827.1|refseq:NP_001304829.1|refseq:NP_001121689.1|refseq:NP_066967.3|refseq:NP_150091.2|dip:DIP-46656N|ensembl:ENSG00000164985(gene)|ensembl:ENST00000380733(transcript)|ensembl:ENST00000380738(transcript)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009408"(response to heat)|go:"GO:0034399"(nuclear periphery)|go:"GO:0035327"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000313(PWWP)|interpro:IPR021567|interpro:IPR035441|interpro:IPR035496|interpro:IPR036218|mint:O75475|rcsb pdb:1Z9E|rcsb pdb:2B4J|rcsb pdb:2M16|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2N3A|rcsb pdb:3F9K|rcsb pdb:3HPG|rcsb pdb:3HPH|rcsb pdb:3U88|rcsb pdb:3ZEH|rcsb pdb:4FU6|rcsb pdb:5N88|rcsb pdb:5OYM|rcsb pdb:5YI9|rcsb pdb:6EMO|rcsb pdb:6EMP|rcsb pdb:6EMQ|rcsb pdb:6EMR|rcsb pdb:6S01|rcsb pdb:6TRJ|rcsb pdb:6TVM|rcsb pdb:6Z2Y|reactome:R-HSA-162592|reactome:R-HSA-164843|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|mint:MINT-8053126(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:MRtOw4kH/FxVku25dO5RQiNTjDA9606 intact-crc:91B5AA92DFE3785D|rigid:8SNUoG3BxkzZIpj6DbpnH/gwuDM false polyprotein fragment:1148-1435(MINT-8053118)|binding-associated region:70-84(MINT-8053120) binding-associated region:361-370(MINT-8053129)|biotin tag:?-?(MINT-8053127) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:O75475 uniprotkb:P04585 intact:EBI-1801773|uniprotkb:O00256|uniprotkb:O95368|uniprotkb:Q6P391|uniprotkb:Q86YB9|uniprotkb:Q9NZI3|uniprotkb:Q9UER6|uniprotkb:D3DRI9|ensembl:ENSP00000370109|ensembl:ENSP00000370114 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:psip1_human(display_long)|uniprotkb:PSIP1(gene name)|psi-mi:PSIP1(display_short)|uniprotkb:DFS70(gene name synonym)|uniprotkb:LEDGF(gene name synonym)|uniprotkb:PSIP2(gene name synonym)|uniprotkb:Lens epithelium-derived growth factor(gene name synonym)|uniprotkb:Transcriptional coactivator p75/p52(gene name synonym)|uniprotkb:Dense fine speckles 70 kDa protein(gene name synonym)|uniprotkb:CLL-associated antigen KW-7(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8539739|mint:MINT-8053154 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001304827.1|refseq:NP_001304829.1|refseq:NP_001121689.1|refseq:NP_066967.3|refseq:NP_150091.2|dip:DIP-46656N|ensembl:ENSG00000164985(gene)|ensembl:ENST00000380733(transcript)|ensembl:ENST00000380738(transcript)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009408"(response to heat)|go:"GO:0034399"(nuclear periphery)|go:"GO:0035327"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000313(PWWP)|interpro:IPR021567|interpro:IPR035441|interpro:IPR035496|interpro:IPR036218|mint:O75475|rcsb pdb:1Z9E|rcsb pdb:2B4J|rcsb pdb:2M16|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2N3A|rcsb pdb:3F9K|rcsb pdb:3HPG|rcsb pdb:3HPH|rcsb pdb:3U88|rcsb pdb:3ZEH|rcsb pdb:4FU6|rcsb pdb:5N88|rcsb pdb:5OYM|rcsb pdb:5YI9|rcsb pdb:6EMO|rcsb pdb:6EMP|rcsb pdb:6EMQ|rcsb pdb:6EMR|rcsb pdb:6S01|rcsb pdb:6TRJ|rcsb pdb:6TVM|rcsb pdb:6Z2Y|reactome:R-HSA-162592|reactome:R-HSA-164843|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|mint:MINT-8053162(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053156(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:MRtOw4kH/FxVku25dO5RQiNTjDA9606 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:ABBFA9091F76F915|rigid:8SNUoG3BxkzZIpj6DbpnH/gwuDM false binding-associated region:401-413(MINT-8053165)|biotin tag:?-?(MINT-8053163) binding-associated region:62-76(MINT-8053159)|polyprotein fragment:1148-1435(MINT-8053157) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04585 uniprotkb:O75475 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-1801773|uniprotkb:O00256|uniprotkb:O95368|uniprotkb:Q6P391|uniprotkb:Q86YB9|uniprotkb:Q9NZI3|uniprotkb:Q9UER6|uniprotkb:D3DRI9|ensembl:ENSP00000370109|ensembl:ENSP00000370114 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:psip1_human(display_long)|uniprotkb:PSIP1(gene name)|psi-mi:PSIP1(display_short)|uniprotkb:DFS70(gene name synonym)|uniprotkb:LEDGF(gene name synonym)|uniprotkb:PSIP2(gene name synonym)|uniprotkb:Lens epithelium-derived growth factor(gene name synonym)|uniprotkb:Transcriptional coactivator p75/p52(gene name synonym)|uniprotkb:Dense fine speckles 70 kDa protein(gene name synonym)|uniprotkb:CLL-associated antigen KW-7(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8539762|mint:MINT-8053173 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053175(identity) refseq:NP_001304827.1|refseq:NP_001304829.1|refseq:NP_001121689.1|refseq:NP_066967.3|refseq:NP_150091.2|dip:DIP-46656N|ensembl:ENSG00000164985(gene)|ensembl:ENST00000380733(transcript)|ensembl:ENST00000380738(transcript)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009408"(response to heat)|go:"GO:0034399"(nuclear periphery)|go:"GO:0035327"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000313(PWWP)|interpro:IPR021567|interpro:IPR035441|interpro:IPR035496|interpro:IPR036218|mint:O75475|rcsb pdb:1Z9E|rcsb pdb:2B4J|rcsb pdb:2M16|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2N3A|rcsb pdb:3F9K|rcsb pdb:3HPG|rcsb pdb:3HPH|rcsb pdb:3U88|rcsb pdb:3ZEH|rcsb pdb:4FU6|rcsb pdb:5N88|rcsb pdb:5OYM|rcsb pdb:5YI9|rcsb pdb:6EMO|rcsb pdb:6EMP|rcsb pdb:6EMQ|rcsb pdb:6EMR|rcsb pdb:6S01|rcsb pdb:6TRJ|rcsb pdb:6TVM|rcsb pdb:6Z2Y|reactome:R-HSA-162592|reactome:R-HSA-164843|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|mint:MINT-8053181(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:MRtOw4kH/FxVku25dO5RQiNTjDA9606 intact-crc:68FC7D70C563D3F6|rigid:8SNUoG3BxkzZIpj6DbpnH/gwuDM false polyprotein fragment:1148-1435(MINT-8053178)|binding-associated region:94-108(MINT-8053176) binding-associated region:401-413(MINT-8053182)|biotin tag:?-?(MINT-8053184) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:O75475 uniprotkb:P04585 intact:EBI-1801773|uniprotkb:O00256|uniprotkb:O95368|uniprotkb:Q6P391|uniprotkb:Q86YB9|uniprotkb:Q9NZI3|uniprotkb:Q9UER6|uniprotkb:D3DRI9|ensembl:ENSP00000370109|ensembl:ENSP00000370114 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:psip1_human(display_long)|uniprotkb:PSIP1(gene name)|psi-mi:PSIP1(display_short)|uniprotkb:DFS70(gene name synonym)|uniprotkb:LEDGF(gene name synonym)|uniprotkb:PSIP2(gene name synonym)|uniprotkb:Lens epithelium-derived growth factor(gene name synonym)|uniprotkb:Transcriptional coactivator p75/p52(gene name synonym)|uniprotkb:Dense fine speckles 70 kDa protein(gene name synonym)|uniprotkb:CLL-associated antigen KW-7(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8539806|mint:MINT-8053190 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001304827.1|refseq:NP_001304829.1|refseq:NP_001121689.1|refseq:NP_066967.3|refseq:NP_150091.2|dip:DIP-46656N|ensembl:ENSG00000164985(gene)|ensembl:ENST00000380733(transcript)|ensembl:ENST00000380738(transcript)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009408"(response to heat)|go:"GO:0034399"(nuclear periphery)|go:"GO:0035327"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000313(PWWP)|interpro:IPR021567|interpro:IPR035441|interpro:IPR035496|interpro:IPR036218|mint:O75475|rcsb pdb:1Z9E|rcsb pdb:2B4J|rcsb pdb:2M16|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2N3A|rcsb pdb:3F9K|rcsb pdb:3HPG|rcsb pdb:3HPH|rcsb pdb:3U88|rcsb pdb:3ZEH|rcsb pdb:4FU6|rcsb pdb:5N88|rcsb pdb:5OYM|rcsb pdb:5YI9|rcsb pdb:6EMO|rcsb pdb:6EMP|rcsb pdb:6EMQ|rcsb pdb:6EMR|rcsb pdb:6S01|rcsb pdb:6TRJ|rcsb pdb:6TVM|rcsb pdb:6Z2Y|reactome:R-HSA-162592|reactome:R-HSA-164843|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|mint:MINT-8053198(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053192(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:MRtOw4kH/FxVku25dO5RQiNTjDA9606 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:2CB1CE4E6C039EC7|rigid:8SNUoG3BxkzZIpj6DbpnH/gwuDM false binding-associated region:401-413(MINT-8053201)|biotin tag:?-?(MINT-8053199) binding-associated region:118-132(MINT-8053195)|polyprotein fragment:1148-1435(MINT-8053193) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04585 uniprotkb:O75475 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-1801773|uniprotkb:O00256|uniprotkb:O95368|uniprotkb:Q6P391|uniprotkb:Q86YB9|uniprotkb:Q9NZI3|uniprotkb:Q9UER6|uniprotkb:D3DRI9|ensembl:ENSP00000370109|ensembl:ENSP00000370114 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:psip1_human(display_long)|uniprotkb:PSIP1(gene name)|psi-mi:PSIP1(display_short)|uniprotkb:DFS70(gene name synonym)|uniprotkb:LEDGF(gene name synonym)|uniprotkb:PSIP2(gene name synonym)|uniprotkb:Lens epithelium-derived growth factor(gene name synonym)|uniprotkb:Transcriptional coactivator p75/p52(gene name synonym)|uniprotkb:Dense fine speckles 70 kDa protein(gene name synonym)|uniprotkb:CLL-associated antigen KW-7(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8539829|mint:MINT-8053207 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053209(identity) refseq:NP_001304827.1|refseq:NP_001304829.1|refseq:NP_001121689.1|refseq:NP_066967.3|refseq:NP_150091.2|dip:DIP-46656N|ensembl:ENSG00000164985(gene)|ensembl:ENST00000380733(transcript)|ensembl:ENST00000380738(transcript)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009408"(response to heat)|go:"GO:0034399"(nuclear periphery)|go:"GO:0035327"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000313(PWWP)|interpro:IPR021567|interpro:IPR035441|interpro:IPR035496|interpro:IPR036218|mint:O75475|rcsb pdb:1Z9E|rcsb pdb:2B4J|rcsb pdb:2M16|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2N3A|rcsb pdb:3F9K|rcsb pdb:3HPG|rcsb pdb:3HPH|rcsb pdb:3U88|rcsb pdb:3ZEH|rcsb pdb:4FU6|rcsb pdb:5N88|rcsb pdb:5OYM|rcsb pdb:5YI9|rcsb pdb:6EMO|rcsb pdb:6EMP|rcsb pdb:6EMQ|rcsb pdb:6EMR|rcsb pdb:6S01|rcsb pdb:6TRJ|rcsb pdb:6TVM|rcsb pdb:6Z2Y|reactome:R-HSA-162592|reactome:R-HSA-164843|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|mint:MINT-8053215(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:MRtOw4kH/FxVku25dO5RQiNTjDA9606 intact-crc:147669ECEE9421A5|rigid:8SNUoG3BxkzZIpj6DbpnH/gwuDM false polyprotein fragment:1148-1435(MINT-8053212)|binding-associated region:98-112(MINT-8053210) binding-associated region:401-413(MINT-8053216)|biotin tag:?-?(MINT-8053218) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:O75475 uniprotkb:P04585 intact:EBI-1801773|uniprotkb:O00256|uniprotkb:O95368|uniprotkb:Q6P391|uniprotkb:Q86YB9|uniprotkb:Q9NZI3|uniprotkb:Q9UER6|uniprotkb:D3DRI9|ensembl:ENSP00000370109|ensembl:ENSP00000370114 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:psip1_human(display_long)|uniprotkb:PSIP1(gene name)|psi-mi:PSIP1(display_short)|uniprotkb:DFS70(gene name synonym)|uniprotkb:LEDGF(gene name synonym)|uniprotkb:PSIP2(gene name synonym)|uniprotkb:Lens epithelium-derived growth factor(gene name synonym)|uniprotkb:Transcriptional coactivator p75/p52(gene name synonym)|uniprotkb:Dense fine speckles 70 kDa protein(gene name synonym)|uniprotkb:CLL-associated antigen KW-7(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8539852|mint:MINT-8053224 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001304827.1|refseq:NP_001304829.1|refseq:NP_001121689.1|refseq:NP_066967.3|refseq:NP_150091.2|dip:DIP-46656N|ensembl:ENSG00000164985(gene)|ensembl:ENST00000380733(transcript)|ensembl:ENST00000380738(transcript)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009408"(response to heat)|go:"GO:0034399"(nuclear periphery)|go:"GO:0035327"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000313(PWWP)|interpro:IPR021567|interpro:IPR035441|interpro:IPR035496|interpro:IPR036218|mint:O75475|rcsb pdb:1Z9E|rcsb pdb:2B4J|rcsb pdb:2M16|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2N3A|rcsb pdb:3F9K|rcsb pdb:3HPG|rcsb pdb:3HPH|rcsb pdb:3U88|rcsb pdb:3ZEH|rcsb pdb:4FU6|rcsb pdb:5N88|rcsb pdb:5OYM|rcsb pdb:5YI9|rcsb pdb:6EMO|rcsb pdb:6EMP|rcsb pdb:6EMQ|rcsb pdb:6EMR|rcsb pdb:6S01|rcsb pdb:6TRJ|rcsb pdb:6TVM|rcsb pdb:6Z2Y|reactome:R-HSA-162592|reactome:R-HSA-164843|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|mint:MINT-8053232(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053226(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:MRtOw4kH/FxVku25dO5RQiNTjDA9606 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:6A743BFC8822D6CE|rigid:8SNUoG3BxkzZIpj6DbpnH/gwuDM false binding-associated region:361-370(MINT-8053233)|biotin tag:?-?(MINT-8053235) polyprotein fragment:1148-1435(MINT-8053229)|binding-associated region:98-112(MINT-8053227) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04585 uniprotkb:O75475 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-1801773|uniprotkb:O00256|uniprotkb:O95368|uniprotkb:Q6P391|uniprotkb:Q86YB9|uniprotkb:Q9NZI3|uniprotkb:Q9UER6|uniprotkb:D3DRI9|ensembl:ENSP00000370109|ensembl:ENSP00000370114 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:psip1_human(display_long)|uniprotkb:PSIP1(gene name)|psi-mi:PSIP1(display_short)|uniprotkb:DFS70(gene name synonym)|uniprotkb:LEDGF(gene name synonym)|uniprotkb:PSIP2(gene name synonym)|uniprotkb:Lens epithelium-derived growth factor(gene name synonym)|uniprotkb:Transcriptional coactivator p75/p52(gene name synonym)|uniprotkb:Dense fine speckles 70 kDa protein(gene name synonym)|uniprotkb:CLL-associated antigen KW-7(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8539898|mint:MINT-8053257 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053259(identity) refseq:NP_001304827.1|refseq:NP_001304829.1|refseq:NP_001121689.1|refseq:NP_066967.3|refseq:NP_150091.2|dip:DIP-46656N|ensembl:ENSG00000164985(gene)|ensembl:ENST00000380733(transcript)|ensembl:ENST00000380738(transcript)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009408"(response to heat)|go:"GO:0034399"(nuclear periphery)|go:"GO:0035327"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000313(PWWP)|interpro:IPR021567|interpro:IPR035441|interpro:IPR035496|interpro:IPR036218|mint:O75475|rcsb pdb:1Z9E|rcsb pdb:2B4J|rcsb pdb:2M16|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2N3A|rcsb pdb:3F9K|rcsb pdb:3HPG|rcsb pdb:3HPH|rcsb pdb:3U88|rcsb pdb:3ZEH|rcsb pdb:4FU6|rcsb pdb:5N88|rcsb pdb:5OYM|rcsb pdb:5YI9|rcsb pdb:6EMO|rcsb pdb:6EMP|rcsb pdb:6EMQ|rcsb pdb:6EMR|rcsb pdb:6S01|rcsb pdb:6TRJ|rcsb pdb:6TVM|rcsb pdb:6Z2Y|reactome:R-HSA-162592|reactome:R-HSA-164843|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|mint:MINT-8053265(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:MRtOw4kH/FxVku25dO5RQiNTjDA9606 intact-crc:52B39C5E0AB569AC|rigid:8SNUoG3BxkzZIpj6DbpnH/gwuDM false binding-associated region:118-132(MINT-8053260)|polyprotein fragment:1148-1435(MINT-8053262) biotin tag:?-?(MINT-8053268)|binding-associated region:361-370(MINT-8053266) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:O75475 uniprotkb:P04585 intact:EBI-1801773|uniprotkb:O00256|uniprotkb:O95368|uniprotkb:Q6P391|uniprotkb:Q86YB9|uniprotkb:Q9NZI3|uniprotkb:Q9UER6|uniprotkb:D3DRI9|ensembl:ENSP00000370109|ensembl:ENSP00000370114 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:psip1_human(display_long)|uniprotkb:PSIP1(gene name)|psi-mi:PSIP1(display_short)|uniprotkb:DFS70(gene name synonym)|uniprotkb:LEDGF(gene name synonym)|uniprotkb:PSIP2(gene name synonym)|uniprotkb:Lens epithelium-derived growth factor(gene name synonym)|uniprotkb:Transcriptional coactivator p75/p52(gene name synonym)|uniprotkb:Dense fine speckles 70 kDa protein(gene name synonym)|uniprotkb:CLL-associated antigen KW-7(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8539875|mint:MINT-8053241 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001304827.1|refseq:NP_001304829.1|refseq:NP_001121689.1|refseq:NP_066967.3|refseq:NP_150091.2|dip:DIP-46656N|ensembl:ENSG00000164985(gene)|ensembl:ENST00000380733(transcript)|ensembl:ENST00000380738(transcript)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009408"(response to heat)|go:"GO:0034399"(nuclear periphery)|go:"GO:0035327"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000313(PWWP)|interpro:IPR021567|interpro:IPR035441|interpro:IPR035496|interpro:IPR036218|mint:O75475|rcsb pdb:1Z9E|rcsb pdb:2B4J|rcsb pdb:2M16|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2N3A|rcsb pdb:3F9K|rcsb pdb:3HPG|rcsb pdb:3HPH|rcsb pdb:3U88|rcsb pdb:3ZEH|rcsb pdb:4FU6|rcsb pdb:5N88|rcsb pdb:5OYM|rcsb pdb:5YI9|rcsb pdb:6EMO|rcsb pdb:6EMP|rcsb pdb:6EMQ|rcsb pdb:6EMR|rcsb pdb:6S01|rcsb pdb:6TRJ|rcsb pdb:6TVM|rcsb pdb:6Z2Y|reactome:R-HSA-162592|reactome:R-HSA-164843|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|mint:MINT-8053249(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053243(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:MRtOw4kH/FxVku25dO5RQiNTjDA9606 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:16FE2F60A3D5249D|rigid:8SNUoG3BxkzZIpj6DbpnH/gwuDM false binding-associated region:361-370(MINT-8053252)|biotin tag:?-?(MINT-8053250) polyprotein fragment:1148-1435(MINT-8053244)|binding-associated region:94-108(MINT-8053246) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75475 uniprotkb:P04585 intact:EBI-1801773|uniprotkb:O00256|uniprotkb:O95368|uniprotkb:Q6P391|uniprotkb:Q86YB9|uniprotkb:Q9NZI3|uniprotkb:Q9UER6|uniprotkb:D3DRI9|ensembl:ENSP00000370109|ensembl:ENSP00000370114 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:psip1_human(display_long)|uniprotkb:PSIP1(gene name)|psi-mi:PSIP1(display_short)|uniprotkb:DFS70(gene name synonym)|uniprotkb:LEDGF(gene name synonym)|uniprotkb:PSIP2(gene name synonym)|uniprotkb:Lens epithelium-derived growth factor(gene name synonym)|uniprotkb:Transcriptional coactivator p75/p52(gene name synonym)|uniprotkb:Dense fine speckles 70 kDa protein(gene name synonym)|uniprotkb:CLL-associated antigen KW-7(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8539944|mint:MINT-8053289 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001304827.1|refseq:NP_001304829.1|refseq:NP_001121689.1|refseq:NP_066967.3|refseq:NP_150091.2|dip:DIP-46656N|ensembl:ENSG00000164985(gene)|ensembl:ENST00000380733(transcript)|ensembl:ENST00000380738(transcript)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009408"(response to heat)|go:"GO:0034399"(nuclear periphery)|go:"GO:0035327"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000313(PWWP)|interpro:IPR021567|interpro:IPR035441|interpro:IPR035496|interpro:IPR036218|mint:O75475|rcsb pdb:1Z9E|rcsb pdb:2B4J|rcsb pdb:2M16|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2N3A|rcsb pdb:3F9K|rcsb pdb:3HPG|rcsb pdb:3HPH|rcsb pdb:3U88|rcsb pdb:3ZEH|rcsb pdb:4FU6|rcsb pdb:5N88|rcsb pdb:5OYM|rcsb pdb:5YI9|rcsb pdb:6EMO|rcsb pdb:6EMP|rcsb pdb:6EMQ|rcsb pdb:6EMR|rcsb pdb:6S01|rcsb pdb:6TRJ|rcsb pdb:6TVM|rcsb pdb:6Z2Y|reactome:R-HSA-162592|reactome:R-HSA-164843|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|mint:MINT-8053297(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053291(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:MRtOw4kH/FxVku25dO5RQiNTjDA9606 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:F41D7418F99FEA86|rigid:8SNUoG3BxkzZIpj6DbpnH/gwuDM false binding-associated region:361-370(MINT-8053298)|biotin tag:?-?(MINT-8053300) polyprotein fragment:1148-1435(MINT-8053294)|binding-associated region:158-172(MINT-8053292) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04585 uniprotkb:O75475 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-1801773|uniprotkb:O00256|uniprotkb:O95368|uniprotkb:Q6P391|uniprotkb:Q86YB9|uniprotkb:Q9NZI3|uniprotkb:Q9UER6|uniprotkb:D3DRI9|ensembl:ENSP00000370109|ensembl:ENSP00000370114 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:psip1_human(display_long)|uniprotkb:PSIP1(gene name)|psi-mi:PSIP1(display_short)|uniprotkb:DFS70(gene name synonym)|uniprotkb:LEDGF(gene name synonym)|uniprotkb:PSIP2(gene name synonym)|uniprotkb:Lens epithelium-derived growth factor(gene name synonym)|uniprotkb:Transcriptional coactivator p75/p52(gene name synonym)|uniprotkb:Dense fine speckles 70 kDa protein(gene name synonym)|uniprotkb:CLL-associated antigen KW-7(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8539967|mint:MINT-8053305 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053307(identity) refseq:NP_001304827.1|refseq:NP_001304829.1|refseq:NP_001121689.1|refseq:NP_066967.3|refseq:NP_150091.2|dip:DIP-46656N|ensembl:ENSG00000164985(gene)|ensembl:ENST00000380733(transcript)|ensembl:ENST00000380738(transcript)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009408"(response to heat)|go:"GO:0034399"(nuclear periphery)|go:"GO:0035327"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000313(PWWP)|interpro:IPR021567|interpro:IPR035441|interpro:IPR035496|interpro:IPR036218|mint:O75475|rcsb pdb:1Z9E|rcsb pdb:2B4J|rcsb pdb:2M16|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2N3A|rcsb pdb:3F9K|rcsb pdb:3HPG|rcsb pdb:3HPH|rcsb pdb:3U88|rcsb pdb:3ZEH|rcsb pdb:4FU6|rcsb pdb:5N88|rcsb pdb:5OYM|rcsb pdb:5YI9|rcsb pdb:6EMO|rcsb pdb:6EMP|rcsb pdb:6EMQ|rcsb pdb:6EMR|rcsb pdb:6S01|rcsb pdb:6TRJ|rcsb pdb:6TVM|rcsb pdb:6Z2Y|reactome:R-HSA-162592|reactome:R-HSA-164843|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|mint:MINT-8053313(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:MRtOw4kH/FxVku25dO5RQiNTjDA9606 intact-crc:DA3B9F5C7CECF9AC|rigid:8SNUoG3BxkzZIpj6DbpnH/gwuDM false binding-associated region:162-176(MINT-8053310)|polyprotein fragment:1148-1435(MINT-8053308) binding-associated region:361-370(MINT-8053316)|biotin tag:?-?(MINT-8053314) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:P04585 uniprotkb:O75475 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-1801773|uniprotkb:O00256|uniprotkb:O95368|uniprotkb:Q6P391|uniprotkb:Q86YB9|uniprotkb:Q9NZI3|uniprotkb:Q9UER6|uniprotkb:D3DRI9|ensembl:ENSP00000370109|ensembl:ENSP00000370114 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:psip1_human(display_long)|uniprotkb:PSIP1(gene name)|psi-mi:PSIP1(display_short)|uniprotkb:DFS70(gene name synonym)|uniprotkb:LEDGF(gene name synonym)|uniprotkb:PSIP2(gene name synonym)|uniprotkb:Lens epithelium-derived growth factor(gene name synonym)|uniprotkb:Transcriptional coactivator p75/p52(gene name synonym)|uniprotkb:Dense fine speckles 70 kDa protein(gene name synonym)|uniprotkb:CLL-associated antigen KW-7(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8539921|mint:MINT-8053273 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053275(identity) refseq:NP_001304827.1|refseq:NP_001304829.1|refseq:NP_001121689.1|refseq:NP_066967.3|refseq:NP_150091.2|dip:DIP-46656N|ensembl:ENSG00000164985(gene)|ensembl:ENST00000380733(transcript)|ensembl:ENST00000380738(transcript)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009408"(response to heat)|go:"GO:0034399"(nuclear periphery)|go:"GO:0035327"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000313(PWWP)|interpro:IPR021567|interpro:IPR035441|interpro:IPR035496|interpro:IPR036218|mint:O75475|rcsb pdb:1Z9E|rcsb pdb:2B4J|rcsb pdb:2M16|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2N3A|rcsb pdb:3F9K|rcsb pdb:3HPG|rcsb pdb:3HPH|rcsb pdb:3U88|rcsb pdb:3ZEH|rcsb pdb:4FU6|rcsb pdb:5N88|rcsb pdb:5OYM|rcsb pdb:5YI9|rcsb pdb:6EMO|rcsb pdb:6EMP|rcsb pdb:6EMQ|rcsb pdb:6EMR|rcsb pdb:6S01|rcsb pdb:6TRJ|rcsb pdb:6TVM|rcsb pdb:6Z2Y|reactome:R-HSA-162592|reactome:R-HSA-164843|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|mint:MINT-8053281(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:MRtOw4kH/FxVku25dO5RQiNTjDA9606 intact-crc:A66B113A2E1AEE5A|rigid:8SNUoG3BxkzZIpj6DbpnH/gwuDM false binding-associated region:154-168(MINT-8053278)|polyprotein fragment:1148-1435(MINT-8053276) biotin tag:?-?(MINT-8053282)|binding-associated region:361-370(MINT-8053284) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:O75475 uniprotkb:P04585 intact:EBI-1801773|uniprotkb:O00256|uniprotkb:O95368|uniprotkb:Q6P391|uniprotkb:Q86YB9|uniprotkb:Q9NZI3|uniprotkb:Q9UER6|uniprotkb:D3DRI9|ensembl:ENSP00000370109|ensembl:ENSP00000370114 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:psip1_human(display_long)|uniprotkb:PSIP1(gene name)|psi-mi:PSIP1(display_short)|uniprotkb:DFS70(gene name synonym)|uniprotkb:LEDGF(gene name synonym)|uniprotkb:PSIP2(gene name synonym)|uniprotkb:Lens epithelium-derived growth factor(gene name synonym)|uniprotkb:Transcriptional coactivator p75/p52(gene name synonym)|uniprotkb:Dense fine speckles 70 kDa protein(gene name synonym)|uniprotkb:CLL-associated antigen KW-7(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540013|mint:MINT-8053337 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001304827.1|refseq:NP_001304829.1|refseq:NP_001121689.1|refseq:NP_066967.3|refseq:NP_150091.2|dip:DIP-46656N|ensembl:ENSG00000164985(gene)|ensembl:ENST00000380733(transcript)|ensembl:ENST00000380738(transcript)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009408"(response to heat)|go:"GO:0034399"(nuclear periphery)|go:"GO:0035327"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000313(PWWP)|interpro:IPR021567|interpro:IPR035441|interpro:IPR035496|interpro:IPR036218|mint:O75475|rcsb pdb:1Z9E|rcsb pdb:2B4J|rcsb pdb:2M16|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2N3A|rcsb pdb:3F9K|rcsb pdb:3HPG|rcsb pdb:3HPH|rcsb pdb:3U88|rcsb pdb:3ZEH|rcsb pdb:4FU6|rcsb pdb:5N88|rcsb pdb:5OYM|rcsb pdb:5YI9|rcsb pdb:6EMO|rcsb pdb:6EMP|rcsb pdb:6EMQ|rcsb pdb:6EMR|rcsb pdb:6S01|rcsb pdb:6TRJ|rcsb pdb:6TVM|rcsb pdb:6Z2Y|reactome:R-HSA-162592|reactome:R-HSA-164843|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|mint:MINT-8053345(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053339(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:MRtOw4kH/FxVku25dO5RQiNTjDA9606 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:29F027025E534514|rigid:8SNUoG3BxkzZIpj6DbpnH/gwuDM false binding-associated region:361-370(MINT-8053348)|biotin tag:?-?(MINT-8053346) polyprotein fragment:1148-1435(MINT-8053340)|binding-associated region:170-184(MINT-8053342) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04585 uniprotkb:O75475 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-1801773|uniprotkb:O00256|uniprotkb:O95368|uniprotkb:Q6P391|uniprotkb:Q86YB9|uniprotkb:Q9NZI3|uniprotkb:Q9UER6|uniprotkb:D3DRI9|ensembl:ENSP00000370109|ensembl:ENSP00000370114 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:psip1_human(display_long)|uniprotkb:PSIP1(gene name)|psi-mi:PSIP1(display_short)|uniprotkb:DFS70(gene name synonym)|uniprotkb:LEDGF(gene name synonym)|uniprotkb:PSIP2(gene name synonym)|uniprotkb:Lens epithelium-derived growth factor(gene name synonym)|uniprotkb:Transcriptional coactivator p75/p52(gene name synonym)|uniprotkb:Dense fine speckles 70 kDa protein(gene name synonym)|uniprotkb:CLL-associated antigen KW-7(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8539990|mint:MINT-8053321 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053323(identity) refseq:NP_001304827.1|refseq:NP_001304829.1|refseq:NP_001121689.1|refseq:NP_066967.3|refseq:NP_150091.2|dip:DIP-46656N|ensembl:ENSG00000164985(gene)|ensembl:ENST00000380733(transcript)|ensembl:ENST00000380738(transcript)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009408"(response to heat)|go:"GO:0034399"(nuclear periphery)|go:"GO:0035327"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000313(PWWP)|interpro:IPR021567|interpro:IPR035441|interpro:IPR035496|interpro:IPR036218|mint:O75475|rcsb pdb:1Z9E|rcsb pdb:2B4J|rcsb pdb:2M16|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2N3A|rcsb pdb:3F9K|rcsb pdb:3HPG|rcsb pdb:3HPH|rcsb pdb:3U88|rcsb pdb:3ZEH|rcsb pdb:4FU6|rcsb pdb:5N88|rcsb pdb:5OYM|rcsb pdb:5YI9|rcsb pdb:6EMO|rcsb pdb:6EMP|rcsb pdb:6EMQ|rcsb pdb:6EMR|rcsb pdb:6S01|rcsb pdb:6TRJ|rcsb pdb:6TVM|rcsb pdb:6Z2Y|reactome:R-HSA-162592|reactome:R-HSA-164843|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|mint:MINT-8053329(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:MRtOw4kH/FxVku25dO5RQiNTjDA9606 intact-crc:35242F1F8D309FB0|rigid:8SNUoG3BxkzZIpj6DbpnH/gwuDM false polyprotein fragment:1148-1435(MINT-8053326)|binding-associated region:166-180(MINT-8053324) biotin tag:?-?(MINT-8053332)|binding-associated region:361-370(MINT-8053330) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:P04585 uniprotkb:O75475 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-1801773|uniprotkb:O00256|uniprotkb:O95368|uniprotkb:Q6P391|uniprotkb:Q86YB9|uniprotkb:Q9NZI3|uniprotkb:Q9UER6|uniprotkb:D3DRI9|ensembl:ENSP00000370109|ensembl:ENSP00000370114 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:psip1_human(display_long)|uniprotkb:PSIP1(gene name)|psi-mi:PSIP1(display_short)|uniprotkb:DFS70(gene name synonym)|uniprotkb:LEDGF(gene name synonym)|uniprotkb:PSIP2(gene name synonym)|uniprotkb:Lens epithelium-derived growth factor(gene name synonym)|uniprotkb:Transcriptional coactivator p75/p52(gene name synonym)|uniprotkb:Dense fine speckles 70 kDa protein(gene name synonym)|uniprotkb:CLL-associated antigen KW-7(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540037|mint:MINT-8053353 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053355(identity) refseq:NP_001304827.1|refseq:NP_001304829.1|refseq:NP_001121689.1|refseq:NP_066967.3|refseq:NP_150091.2|dip:DIP-46656N|ensembl:ENSG00000164985(gene)|ensembl:ENST00000380733(transcript)|ensembl:ENST00000380738(transcript)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009408"(response to heat)|go:"GO:0034399"(nuclear periphery)|go:"GO:0035327"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000313(PWWP)|interpro:IPR021567|interpro:IPR035441|interpro:IPR035496|interpro:IPR036218|mint:O75475|rcsb pdb:1Z9E|rcsb pdb:2B4J|rcsb pdb:2M16|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2N3A|rcsb pdb:3F9K|rcsb pdb:3HPG|rcsb pdb:3HPH|rcsb pdb:3U88|rcsb pdb:3ZEH|rcsb pdb:4FU6|rcsb pdb:5N88|rcsb pdb:5OYM|rcsb pdb:5YI9|rcsb pdb:6EMO|rcsb pdb:6EMP|rcsb pdb:6EMQ|rcsb pdb:6EMR|rcsb pdb:6S01|rcsb pdb:6TRJ|rcsb pdb:6TVM|rcsb pdb:6Z2Y|reactome:R-HSA-162592|reactome:R-HSA-164843|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|mint:MINT-8053361(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:MRtOw4kH/FxVku25dO5RQiNTjDA9606 intact-crc:7EF705B2EFF53291|rigid:8SNUoG3BxkzZIpj6DbpnH/gwuDM false polyprotein fragment:1148-1435(MINT-8053358)|binding-associated region:214-228(MINT-8053356) biotin tag:?-?(MINT-8053364)|binding-associated region:361-370(MINT-8053362) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:O75475 uniprotkb:P04585 intact:EBI-1801773|uniprotkb:O00256|uniprotkb:O95368|uniprotkb:Q6P391|uniprotkb:Q86YB9|uniprotkb:Q9NZI3|uniprotkb:Q9UER6|uniprotkb:D3DRI9|ensembl:ENSP00000370109|ensembl:ENSP00000370114 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:psip1_human(display_long)|uniprotkb:PSIP1(gene name)|psi-mi:PSIP1(display_short)|uniprotkb:DFS70(gene name synonym)|uniprotkb:LEDGF(gene name synonym)|uniprotkb:PSIP2(gene name synonym)|uniprotkb:Lens epithelium-derived growth factor(gene name synonym)|uniprotkb:Transcriptional coactivator p75/p52(gene name synonym)|uniprotkb:Dense fine speckles 70 kDa protein(gene name synonym)|uniprotkb:CLL-associated antigen KW-7(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540074|mint:MINT-8053370 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001304827.1|refseq:NP_001304829.1|refseq:NP_001121689.1|refseq:NP_066967.3|refseq:NP_150091.2|dip:DIP-46656N|ensembl:ENSG00000164985(gene)|ensembl:ENST00000380733(transcript)|ensembl:ENST00000380738(transcript)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009408"(response to heat)|go:"GO:0034399"(nuclear periphery)|go:"GO:0035327"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000313(PWWP)|interpro:IPR021567|interpro:IPR035441|interpro:IPR035496|interpro:IPR036218|mint:O75475|rcsb pdb:1Z9E|rcsb pdb:2B4J|rcsb pdb:2M16|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2N3A|rcsb pdb:3F9K|rcsb pdb:3HPG|rcsb pdb:3HPH|rcsb pdb:3U88|rcsb pdb:3ZEH|rcsb pdb:4FU6|rcsb pdb:5N88|rcsb pdb:5OYM|rcsb pdb:5YI9|rcsb pdb:6EMO|rcsb pdb:6EMP|rcsb pdb:6EMQ|rcsb pdb:6EMR|rcsb pdb:6S01|rcsb pdb:6TRJ|rcsb pdb:6TVM|rcsb pdb:6Z2Y|reactome:R-HSA-162592|reactome:R-HSA-164843|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|mint:MINT-8053378(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053372(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:MRtOw4kH/FxVku25dO5RQiNTjDA9606 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:2C8160903870364D|rigid:8SNUoG3BxkzZIpj6DbpnH/gwuDM false binding-associated region:361-370(MINT-8053381)|biotin tag:?-?(MINT-8053379) binding-associated region:218-232(MINT-8053375)|polyprotein fragment:1148-1435(MINT-8053373) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75475 uniprotkb:P04585 intact:EBI-1801773|uniprotkb:O00256|uniprotkb:O95368|uniprotkb:Q6P391|uniprotkb:Q86YB9|uniprotkb:Q9NZI3|uniprotkb:Q9UER6|uniprotkb:D3DRI9|ensembl:ENSP00000370109|ensembl:ENSP00000370114 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:psip1_human(display_long)|uniprotkb:PSIP1(gene name)|psi-mi:PSIP1(display_short)|uniprotkb:DFS70(gene name synonym)|uniprotkb:LEDGF(gene name synonym)|uniprotkb:PSIP2(gene name synonym)|uniprotkb:Lens epithelium-derived growth factor(gene name synonym)|uniprotkb:Transcriptional coactivator p75/p52(gene name synonym)|uniprotkb:Dense fine speckles 70 kDa protein(gene name synonym)|uniprotkb:CLL-associated antigen KW-7(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540110|mint:MINT-8053386 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001304827.1|refseq:NP_001304829.1|refseq:NP_001121689.1|refseq:NP_066967.3|refseq:NP_150091.2|dip:DIP-46656N|ensembl:ENSG00000164985(gene)|ensembl:ENST00000380733(transcript)|ensembl:ENST00000380738(transcript)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009408"(response to heat)|go:"GO:0034399"(nuclear periphery)|go:"GO:0035327"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000313(PWWP)|interpro:IPR021567|interpro:IPR035441|interpro:IPR035496|interpro:IPR036218|mint:O75475|rcsb pdb:1Z9E|rcsb pdb:2B4J|rcsb pdb:2M16|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2N3A|rcsb pdb:3F9K|rcsb pdb:3HPG|rcsb pdb:3HPH|rcsb pdb:3U88|rcsb pdb:3ZEH|rcsb pdb:4FU6|rcsb pdb:5N88|rcsb pdb:5OYM|rcsb pdb:5YI9|rcsb pdb:6EMO|rcsb pdb:6EMP|rcsb pdb:6EMQ|rcsb pdb:6EMR|rcsb pdb:6S01|rcsb pdb:6TRJ|rcsb pdb:6TVM|rcsb pdb:6Z2Y|reactome:R-HSA-162592|reactome:R-HSA-164843|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|mint:MINT-8053394(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053388(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:MRtOw4kH/FxVku25dO5RQiNTjDA9606 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:02A78BD4BD032567|rigid:8SNUoG3BxkzZIpj6DbpnH/gwuDM false binding-associated region:361-370(MINT-8053395)|biotin tag:?-?(MINT-8053397) polyprotein fragment:1148-1435(MINT-8053391)|binding-associated region:222-236(MINT-8053389) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04585 uniprotkb:O75475 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-1801773|uniprotkb:O00256|uniprotkb:O95368|uniprotkb:Q6P391|uniprotkb:Q86YB9|uniprotkb:Q9NZI3|uniprotkb:Q9UER6|uniprotkb:D3DRI9|ensembl:ENSP00000370109|ensembl:ENSP00000370114 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:psip1_human(display_long)|uniprotkb:PSIP1(gene name)|psi-mi:PSIP1(display_short)|uniprotkb:DFS70(gene name synonym)|uniprotkb:LEDGF(gene name synonym)|uniprotkb:PSIP2(gene name synonym)|uniprotkb:Lens epithelium-derived growth factor(gene name synonym)|uniprotkb:Transcriptional coactivator p75/p52(gene name synonym)|uniprotkb:Dense fine speckles 70 kDa protein(gene name synonym)|uniprotkb:CLL-associated antigen KW-7(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540133|mint:MINT-8053402 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053404(identity) refseq:NP_001304827.1|refseq:NP_001304829.1|refseq:NP_001121689.1|refseq:NP_066967.3|refseq:NP_150091.2|dip:DIP-46656N|ensembl:ENSG00000164985(gene)|ensembl:ENST00000380733(transcript)|ensembl:ENST00000380738(transcript)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009408"(response to heat)|go:"GO:0034399"(nuclear periphery)|go:"GO:0035327"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000313(PWWP)|interpro:IPR021567|interpro:IPR035441|interpro:IPR035496|interpro:IPR036218|mint:O75475|rcsb pdb:1Z9E|rcsb pdb:2B4J|rcsb pdb:2M16|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2N3A|rcsb pdb:3F9K|rcsb pdb:3HPG|rcsb pdb:3HPH|rcsb pdb:3U88|rcsb pdb:3ZEH|rcsb pdb:4FU6|rcsb pdb:5N88|rcsb pdb:5OYM|rcsb pdb:5YI9|rcsb pdb:6EMO|rcsb pdb:6EMP|rcsb pdb:6EMQ|rcsb pdb:6EMR|rcsb pdb:6S01|rcsb pdb:6TRJ|rcsb pdb:6TVM|rcsb pdb:6Z2Y|reactome:R-HSA-162592|reactome:R-HSA-164843|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|mint:MINT-8053410(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:MRtOw4kH/FxVku25dO5RQiNTjDA9606 intact-crc:F75E17B137BCE7D8|rigid:8SNUoG3BxkzZIpj6DbpnH/gwuDM false binding-associated region:242-256(MINT-8053407)|polyprotein fragment:1148-1435(MINT-8053405) binding-associated region:361-370(MINT-8053413)|biotin tag:?-?(MINT-8053411) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:P69718 uniprotkb:P04585 intact:EBI-8540156|intact:MINT-8053053|uniprotkb:P04617 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:rev_hv1h3(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11707(hv1h3)|taxid:11707("Human immunodeficiency virus type 1 group M subtype B (isolate HXB3)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540175|mint:MINT-8053418 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-61764N|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0051028"(mRNA transport)|interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:3LPH|rcsb pdb:4PMI|mint:MINT-8053434(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053420(identity) - comment:mint - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:MxSi+DZ5ahh2uJZAvCq/FnlK4UY11707 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:0AF234B88CDE3D90|rigid:GAYsC4HLLqwfI6M+tvnHZ1bbjyg false biotin tag:?-?(MINT-8053435)|binding-associated region:53-67(MINT-8053438) polyprotein fragment:1148-1435(MINT-8053423)|binding-associated region:66-80(MINT-8053421) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P69718 uniprotkb:P04585 intact:EBI-8540156|intact:MINT-8053053|uniprotkb:P04617 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:rev_hv1h3(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11707(hv1h3)|taxid:11707("Human immunodeficiency virus type 1 group M subtype B (isolate HXB3)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540221|mint:MINT-8053458 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-61764N|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0051028"(mRNA transport)|interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:3LPH|rcsb pdb:4PMI|mint:MINT-8053466(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053460(identity) - comment:mint - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:MxSi+DZ5ahh2uJZAvCq/FnlK4UY11707 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:14EABD344689115D|rigid:GAYsC4HLLqwfI6M+tvnHZ1bbjyg false biotin tag:?-?(MINT-8053467)|binding-associated region:53-67(MINT-8053469) binding-associated region:170-184(MINT-8053461)|polyprotein fragment:1148-1435(MINT-8053463) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P69718 uniprotkb:P04585 intact:EBI-8540156|intact:MINT-8053053|uniprotkb:P04617 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:rev_hv1h3(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11707(hv1h3)|taxid:11707("Human immunodeficiency virus type 1 group M subtype B (isolate HXB3)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540198|mint:MINT-8053442 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-61764N|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0051028"(mRNA transport)|interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:3LPH|rcsb pdb:4PMI|mint:MINT-8053450(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053444(identity) - comment:mint - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:MxSi+DZ5ahh2uJZAvCq/FnlK4UY11707 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:755A807D8FDA74F7|rigid:GAYsC4HLLqwfI6M+tvnHZ1bbjyg false binding-associated region:53-67(MINT-8053451)|biotin tag:?-?(MINT-8053453) binding-associated region:70-84(MINT-8053447)|polyprotein fragment:1148-1435(MINT-8053445) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P69718 uniprotkb:P04585 intact:EBI-8540156|intact:MINT-8053053|uniprotkb:P04617 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:rev_hv1h3(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11707(hv1h3)|taxid:11707("Human immunodeficiency virus type 1 group M subtype B (isolate HXB3)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540244|mint:MINT-8053474 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-61764N|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0051028"(mRNA transport)|interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:3LPH|rcsb pdb:4PMI|mint:MINT-8053482(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053476(identity) - comment:mint - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:MxSi+DZ5ahh2uJZAvCq/FnlK4UY11707 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:AEBEEB2D640466BF|rigid:GAYsC4HLLqwfI6M+tvnHZ1bbjyg false binding-associated region:53-67(MINT-8053483)|biotin tag:?-?(MINT-8053485) binding-associated region:174-188(MINT-8053479)|polyprotein fragment:1148-1435(MINT-8053477) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P69718 uniprotkb:P04585 intact:EBI-8540156|intact:MINT-8053053|uniprotkb:P04617 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:rev_hv1h3(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11707(hv1h3)|taxid:11707("Human immunodeficiency virus type 1 group M subtype B (isolate HXB3)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540290|mint:MINT-8053523 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-61764N|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0051028"(mRNA transport)|interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:3LPH|rcsb pdb:4PMI|mint:MINT-8053531(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053525(identity) - comment:mint - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:MxSi+DZ5ahh2uJZAvCq/FnlK4UY11707 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:B49FB779C0E1A172|rigid:GAYsC4HLLqwfI6M+tvnHZ1bbjyg false binding-associated region:13-23(MINT-8053532)|biotin tag:?-?(MINT-8053534) polyprotein fragment:1148-1435(MINT-8053526)|binding-associated region:122-136(MINT-8053528) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P69718 uniprotkb:P04585 intact:EBI-8540156|intact:MINT-8053053|uniprotkb:P04617 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:rev_hv1h3(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11707(hv1h3)|taxid:11707("Human immunodeficiency virus type 1 group M subtype B (isolate HXB3)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540267|mint:MINT-8053506 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-61764N|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0051028"(mRNA transport)|interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:3LPH|rcsb pdb:4PMI|mint:MINT-8053514(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053508(identity) - comment:mint - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:MxSi+DZ5ahh2uJZAvCq/FnlK4UY11707 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:B1ECA453F294528A|rigid:GAYsC4HLLqwfI6M+tvnHZ1bbjyg false binding-associated region:13-23(MINT-8053517)|biotin tag:?-?(MINT-8053515) polyprotein fragment:1148-1435(MINT-8053511)|binding-associated region:118-132(MINT-8053509) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P69718 uniprotkb:P04585 intact:EBI-8540156|intact:MINT-8053053|uniprotkb:P04617 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:rev_hv1h3(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11707(hv1h3)|taxid:11707("Human immunodeficiency virus type 1 group M subtype B (isolate HXB3)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540313|mint:MINT-8053539 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-61764N|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0051028"(mRNA transport)|interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:3LPH|rcsb pdb:4PMI|mint:MINT-8053547(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053541(identity) - comment:mint - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:MxSi+DZ5ahh2uJZAvCq/FnlK4UY11707 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:650A88EBABC385F2|rigid:GAYsC4HLLqwfI6M+tvnHZ1bbjyg false biotin tag:?-?(MINT-8053548)|binding-associated region:13-23(MINT-8053550) polyprotein fragment:1148-1435(MINT-8053544)|binding-associated region:170-184(MINT-8053542) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P69718 uniprotkb:P04585 intact:EBI-8540156|intact:MINT-8053053|uniprotkb:P04617 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:rev_hv1h3(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11707(hv1h3)|taxid:11707("Human immunodeficiency virus type 1 group M subtype B (isolate HXB3)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540336|mint:MINT-8053555 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-61764N|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0051028"(mRNA transport)|interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:3LPH|rcsb pdb:4PMI|mint:MINT-8053563(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053557(identity) - comment:mint - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:MxSi+DZ5ahh2uJZAvCq/FnlK4UY11707 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:DF5EDEF2894EF210|rigid:GAYsC4HLLqwfI6M+tvnHZ1bbjyg false binding-associated region:13-23(MINT-8053564)|biotin tag:?-?(MINT-8053566) binding-associated region:174-188(MINT-8053560)|polyprotein fragment:1148-1435(MINT-8053558) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04585 uniprotkb:P04585 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540385|mint:MINT-8053597 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053599(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053605(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:99467D522350F121|rigid:nj+NNwCMsCEn0fSzHso4hJYn+eI false binding-associated region:66-80(MINT-8053602)|polyprotein fragment:1148-1435(MINT-8053600) polyprotein fragment:1148-1435(MINT-8053608)|biotin tag:?-?(MINT-8053610)|binding-associated region:171-187(MINT-8053606) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:P04585 uniprotkb:P04585 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540359|mint:MINT-8053571 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053573(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053587(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:D6A2AEB940519491|rigid:nj+NNwCMsCEn0fSzHso4hJYn+eI false polyprotein fragment:1148-1435(MINT-8053576)|binding-associated region:62-76(MINT-8053574) binding-associated region:171-187(MINT-8053593)|biotin tag:?-?(MINT-8053588)|polyprotein fragment:1148-1435(MINT-8053591) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:P04585 uniprotkb:P04585 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540411|mint:MINT-8053615 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053617(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053623(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:E45F7B10209F2BA1|rigid:nj+NNwCMsCEn0fSzHso4hJYn+eI false polyprotein fragment:1148-1435(MINT-8053620)|binding-associated region:94-108(MINT-8053618) binding-associated region:171-187(MINT-8053628)|biotin tag:?-?(MINT-8053624)|polyprotein fragment:1148-1435(MINT-8053626) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:P04585 uniprotkb:P04585 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540437|mint:MINT-8053633 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053641(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053635(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:E0FF5A0CF76AC7BE|rigid:nj+NNwCMsCEn0fSzHso4hJYn+eI false binding-associated region:171-187(MINT-8053642)|biotin tag:?-?(MINT-8053646)|polyprotein fragment:1148-1435(MINT-8053644) polyprotein fragment:1148-1435(MINT-8053636)|binding-associated region:118-132(MINT-8053638) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04585 uniprotkb:P04585 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540463|mint:MINT-8053651 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053653(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053659(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:434656E4ACA74C1F|rigid:nj+NNwCMsCEn0fSzHso4hJYn+eI false polyprotein fragment:1148-1435(MINT-8053656)|binding-associated region:122-136(MINT-8053654) binding-associated region:171-187(MINT-8053664)|polyprotein fragment:1148-1435(MINT-8053662)|biotin tag:?-?(MINT-8053660) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:P04585 uniprotkb:P04585 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540489|mint:MINT-8053669 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053671(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053677(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:FE6D90A868FC1D5A|rigid:nj+NNwCMsCEn0fSzHso4hJYn+eI false binding-associated region:126-140(MINT-8053674)|polyprotein fragment:1148-1435(MINT-8053672) polyprotein fragment:1148-1435(MINT-8053680)|biotin tag:?-?(MINT-8053682)|binding-associated region:171-187(MINT-8053678) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:P04585 uniprotkb:P04585 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540523|mint:MINT-8053687 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053689(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053695(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:122D972987F12E09|rigid:nj+NNwCMsCEn0fSzHso4hJYn+eI false binding-associated region:154-168(MINT-8053690)|polyprotein fragment:1148-1435(MINT-8053692) polyprotein fragment:1148-1435(MINT-8053698)|biotin tag:?-?(MINT-8053696)|binding-associated region:171-187(MINT-8053700) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:P04585 uniprotkb:P04585 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540573|mint:MINT-8053705 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053713(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053707(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:3E00D9B2393D4E81|rigid:nj+NNwCMsCEn0fSzHso4hJYn+eI false binding-associated region:171-187(MINT-8053714)|polyprotein fragment:1148-1435(MINT-8053716)|biotin tag:?-?(MINT-8053718) polyprotein fragment:1148-1435(MINT-8053708)|binding-associated region:170-184(MINT-8053710) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04585 uniprotkb:P04585 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540613|mint:MINT-8053723 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053725(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053731(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:5E091EEC8CDCD75A|rigid:nj+NNwCMsCEn0fSzHso4hJYn+eI false polyprotein fragment:1148-1435(MINT-8053728)|binding-associated region:182-196(MINT-8053726) binding-associated region:171-187(MINT-8053736)|polyprotein fragment:1148-1435(MINT-8053734)|biotin tag:?-?(MINT-8053732) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:P04585 uniprotkb:P04585 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540666|mint:MINT-8053741 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053743(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053749(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:EA1480D9E77FB280|rigid:nj+NNwCMsCEn0fSzHso4hJYn+eI false binding-associated region:210-224(MINT-8053746)|polyprotein fragment:1148-1435(MINT-8053744) binding-associated region:171-187(MINT-8053750)|polyprotein fragment:1148-1435(MINT-8053752)|biotin tag:?-?(MINT-8053754) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:P04585 uniprotkb:P04585 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540742|mint:MINT-8053777 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053779(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053785(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:2B92C76F0B652CFA|rigid:nj+NNwCMsCEn0fSzHso4hJYn+eI false polyprotein fragment:1148-1435(MINT-8053780)|binding-associated region:218-232(MINT-8053782) polyprotein fragment:1148-1435(MINT-8053788)|biotin tag:?-?(MINT-8053790)|binding-associated region:171-187(MINT-8053786) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:P04585 uniprotkb:P04585 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540716|mint:MINT-8053759 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053761(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053767(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:349370E59165CB65|rigid:nj+NNwCMsCEn0fSzHso4hJYn+eI false polyprotein fragment:1148-1435(MINT-8053764)|binding-associated region:214-228(MINT-8053762) binding-associated region:171-187(MINT-8053772)|biotin tag:?-?(MINT-8053768)|polyprotein fragment:1148-1435(MINT-8053770) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:P04585 uniprotkb:P04585 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540795|mint:MINT-8053795 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053803(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053797(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:B1458497155E21C6|rigid:nj+NNwCMsCEn0fSzHso4hJYn+eI false biotin tag:?-?(MINT-8053804)|polyprotein fragment:1148-1435(MINT-8053806)|binding-associated region:171-187(MINT-8053808) polyprotein fragment:1148-1435(MINT-8053800)|binding-associated region:238-252(MINT-8053798) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04585 uniprotkb:P04585 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540821|mint:MINT-8053814 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053817(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053816(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:09A41A2184C37D2F|rigid:nj+NNwCMsCEn0fSzHso4hJYn+eI false binding-associated region:174-188(MINT-8053830)|mutation disrupting interaction:188-188(MINT-8055823)|polyprotein fragment:1148-1435(MINT-8053828)|biotin tag:?-?(MINT-8053825) binding-associated region:82-96(MINT-8053822)|polyprotein fragment:1148-1435(MINT-8053820) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04585 uniprotkb:P04585 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540852|mint:MINT-8053836 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053844(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053838(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:FDF5B6A05482E406|rigid:nj+NNwCMsCEn0fSzHso4hJYn+eI false biotin tag:?-?(MINT-8053849)|binding-associated region:174-188(MINT-8053845)|polyprotein fragment:1148-1435(MINT-8053847) polyprotein fragment:1148-1435(MINT-8053841)|binding-associated region:94-108(MINT-8053839) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04585 uniprotkb:P04585 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540879|mint:MINT-8053854 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053856(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053862(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:D386F34516E7787A|rigid:nj+NNwCMsCEn0fSzHso4hJYn+eI false polyprotein fragment:1148-1435(MINT-8053857)|binding-associated region:110-124(MINT-8053859) mutation disrupting interaction:188-188(MINT-8055835)|binding-associated region:174-188(MINT-8053867)|polyprotein fragment:1148-1435(MINT-8053865)|biotin tag:?-?(MINT-8053863) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:P04585 uniprotkb:P04585 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540910|mint:MINT-8053872 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053880(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053874(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:CD1515E37E791BA5|rigid:nj+NNwCMsCEn0fSzHso4hJYn+eI false biotin tag:?-?(MINT-8053885)|binding-associated region:174-188(MINT-8053881)|polyprotein fragment:1148-1435(MINT-8053883) polyprotein fragment:1148-1435(MINT-8053877)|binding-associated region:118-132(MINT-8053875) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04585 uniprotkb:P04585 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540937|mint:MINT-8053890 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053898(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053892(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:20BAAF8053310286|rigid:nj+NNwCMsCEn0fSzHso4hJYn+eI false binding-associated region:174-188(MINT-8053903)|biotin tag:?-?(MINT-8053899)|polyprotein fragment:1148-1435(MINT-8053901) polyprotein fragment:1148-1435(MINT-8053893)|binding-associated region:122-136(MINT-8053895) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04585 uniprotkb:P04585 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540964|mint:MINT-8053908 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053916(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053910(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:BBDEF524C3E7CE00|rigid:nj+NNwCMsCEn0fSzHso4hJYn+eI false biotin tag:?-?(MINT-8053921)|polyprotein fragment:1148-1435(MINT-8053919)|mutation disrupting interaction:188-188(MINT-8055840)|binding-associated region:174-188(MINT-8053917) polyprotein fragment:1148-1435(MINT-8053913)|binding-associated region:154-168(MINT-8053911) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04585 uniprotkb:P04585 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8540995|mint:MINT-8053926 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053934(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053928(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:4D7480C5D21EDA40|rigid:nj+NNwCMsCEn0fSzHso4hJYn+eI false biotin tag:?-?(MINT-8053935)|binding-associated region:174-188(MINT-8053939)|polyprotein fragment:1148-1435(MINT-8053937) polyprotein fragment:1148-1435(MINT-8053929)|binding-associated region:170-184(MINT-8053931) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04585 uniprotkb:P04585 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8541022|mint:MINT-8053944 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053946(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053952(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:AA4E2AF4BDC9B95B|rigid:nj+NNwCMsCEn0fSzHso4hJYn+eI false polyprotein fragment:1148-1435(MINT-8053949)|binding-associated region:174-188(MINT-8053947) biotin tag:?-?(MINT-8053957)|binding-associated region:174-188(MINT-8053953)|polyprotein fragment:1148-1435(MINT-8053955) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:P04585 uniprotkb:P04585 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8541049|mint:MINT-8053962 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053964(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053970(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:F2F61B117CA59B92|rigid:nj+NNwCMsCEn0fSzHso4hJYn+eI false binding-associated region:182-196(MINT-8053967)|polyprotein fragment:1148-1435(MINT-8053965) polyprotein fragment:1148-1435(MINT-8053973)|binding-associated region:174-188(MINT-8053975)|biotin tag:?-?(MINT-8053971)|mutation disrupting interaction:188-188(MINT-8055846) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:P04585 uniprotkb:P04585 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8541080|mint:MINT-8053980 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053982(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8053988(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:B7012A7461692B79|rigid:nj+NNwCMsCEn0fSzHso4hJYn+eI false polyprotein fragment:1148-1435(MINT-8053985)|binding-associated region:186-200(MINT-8053983) biotin tag:?-?(MINT-8053993)|binding-associated region:174-188(MINT-8053989)|mutation disrupting interaction:188-188(MINT-8055853)|polyprotein fragment:1148-1435(MINT-8053991) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:P04585 uniprotkb:P04585 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8541111|mint:MINT-8053998 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8054000(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8054006(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:93570C4B1D23C6B3|rigid:nj+NNwCMsCEn0fSzHso4hJYn+eI false binding-associated region:70-84(MINT-8054003)|polyprotein fragment:1148-1435(MINT-8054001) mutation increasing interaction:188-188(MINT-8055828)|polyprotein fragment:1148-1435(MINT-8054009)|biotin tag:?-?(MINT-8054007)|binding-associated region:174-188(MINT-8054011) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:P04585 uniprotkb:P04585 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8541141|mint:MINT-8054037 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8054045(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8054039(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:F55DA0E57BBA80FA|rigid:nj+NNwCMsCEn0fSzHso4hJYn+eI false binding-associated region:174-188(MINT-8054050)|biotin tag:?-?(MINT-8054046)|polyprotein fragment:1148-1435(MINT-8054048)|mutation increasing interaction:188-188(MINT-8055832) polyprotein fragment:1148-1435(MINT-8054040)|binding-associated region:98-112(MINT-8054042) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04585 uniprotkb:P04585 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8541171|mint:MINT-8054145 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8054147(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8054153(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:90E86E40ADB2C86D|rigid:nj+NNwCMsCEn0fSzHso4hJYn+eI false binding-associated region:222-236(MINT-8054150)|polyprotein fragment:1148-1435(MINT-8054148) polyprotein fragment:1148-1435(MINT-8054156)|mutation increasing interaction:188-188(MINT-8055857)|biotin tag:?-?(MINT-8054154)|binding-associated region:174-188(MINT-8054158) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) uniprotkb:P04585 uniprotkb:P04585 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8541201|mint:MINT-8054163 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8054171(identity) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8054165(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 intact-crc:0A4831B48A84FD92|rigid:nj+NNwCMsCEn0fSzHso4hJYn+eI false mutation increasing interaction:188-188(MINT-8055861)|polyprotein fragment:1148-1435(MINT-8054174)|biotin tag:?-?(MINT-8054176)|binding-associated region:174-188(MINT-8054172) polyprotein fragment:1148-1435(MINT-8054168)|binding-associated region:238-252(MINT-8054166) - - psi-mi:"MI:0411"(enzyme linked immunosorbent assay) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04585 uniprotkb:O75475 intact:EBI-3989067|uniprotkb:Q9WJC5|uniprotkb:O09777 intact:EBI-1801773|uniprotkb:O00256|uniprotkb:O95368|uniprotkb:Q6P391|uniprotkb:Q86YB9|uniprotkb:Q9NZI3|uniprotkb:Q9UER6|uniprotkb:D3DRI9|ensembl:ENSP00000370109|ensembl:ENSP00000370114 psi-mi:pol_hv1h2(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:psip1_human(display_long)|uniprotkb:PSIP1(gene name)|psi-mi:PSIP1(display_short)|uniprotkb:DFS70(gene name synonym)|uniprotkb:LEDGF(gene name synonym)|uniprotkb:PSIP2(gene name synonym)|uniprotkb:Lens epithelium-derived growth factor(gene name synonym)|uniprotkb:Transcriptional coactivator p75/p52(gene name synonym)|uniprotkb:Dense fine speckles 70 kDa protein(gene name synonym)|uniprotkb:CLL-associated antigen KW-7(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Levin et al. (2011) mint:MINT-8053048|pubmed:21156026|doi:10.1111/j.1742-4658.2010.07952|mint:fj-10-0374.r3 taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8541231|mint:MINT-8055897 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6BSG|rcsb pdb:6BSH|rcsb pdb:6BSI|rcsb pdb:6BSJ|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008233"(peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0008907"(integrase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019058"(viral life cycle)|go:"GO:0019072"(viral genome packaging)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|rcsb pdb:4I7F|rcsb pdb:6SKK|rcsb pdb:6SKM|rcsb pdb:6SKN|rcsb pdb:6SLQ|rcsb pdb:5IM7|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1H|rcsb pdb:4KSE|rcsb pdb:4QLH|refseq:NP_057849.4|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|rcsb pdb:1A30|rcsb pdb:1BV7|rcsb pdb:1BV9|rcsb pdb:1BVE|rcsb pdb:1BVG|rcsb pdb:1BWA|rcsb pdb:1BWB|rcsb pdb:1C0T|rcsb pdb:1C0U|rcsb pdb:1C1B|rcsb pdb:1C1C|rcsb pdb:1DMP|rcsb pdb:1DTQ|rcsb pdb:1DTT|rcsb pdb:1E6J|rcsb pdb:1EP4|rcsb pdb:1ESK|rcsb pdb:1EX4|rcsb pdb:1EXQ|rcsb pdb:1FB7|rcsb pdb:1FK9|rcsb pdb:1FKO|rcsb pdb:1FKP|rcsb pdb:1G6L|rcsb pdb:1HIV|rcsb pdb:1HVH|rcsb pdb:1HVR|rcsb pdb:1HWR|rcsb pdb:1HXB|rcsb pdb:1JKH|rcsb pdb:1JLA|rcsb pdb:1JLB|rcsb pdb:1JLC|rcsb pdb:1JLE|rcsb pdb:1JLF|rcsb pdb:1JLG|rcsb pdb:1JLQ|rcsb pdb:1KLM|rcsb pdb:1LV1|rcsb pdb:1LW0|rcsb pdb:1LW2|rcsb pdb:1LWC|rcsb pdb:1LWE|rcsb pdb:1LWF|rcsb pdb:1NCP|rcsb pdb:1O1W|rcsb pdb:1ODW|rcsb pdb:1ODY|rcsb pdb:1QBR|rcsb pdb:1QBS|rcsb pdb:1QBT|rcsb pdb:1QBU|rcsb pdb:1REV|rcsb pdb:1RT1|rcsb pdb:1RT2|rcsb pdb:1RT3|rcsb pdb:1RT4|rcsb pdb:1RT5|rcsb pdb:1RT6|rcsb pdb:1RT7|rcsb pdb:1RTD|rcsb pdb:1RTH|rcsb pdb:1RTI|rcsb pdb:1RTJ|rcsb pdb:1S1T|rcsb pdb:1S1U|rcsb pdb:1S1V|rcsb pdb:1S1W|rcsb pdb:1S1X|rcsb pdb:1T05|rcsb pdb:1TAM|rcsb pdb:1TKT|rcsb pdb:1TKX|rcsb pdb:1TKZ|rcsb pdb:1TL1|rcsb pdb:1TL3|rcsb pdb:1VRT|rcsb pdb:1VRU|rcsb pdb:2HND|rcsb pdb:2HNY|rcsb pdb:2HNZ|rcsb pdb:2KOD|rcsb pdb:2NPH|rcsb pdb:2OPP|rcsb pdb:2OPQ|rcsb pdb:2OPR|rcsb pdb:2OPS|rcsb pdb:2RF2|rcsb pdb:2RKI|rcsb pdb:2WHH|rcsb pdb:2WOM|rcsb pdb:2WON|rcsb pdb:3AO2|rcsb pdb:3C6T|rcsb pdb:3C6U|rcsb pdb:3DI6|rcsb pdb:3DLE|rcsb pdb:3DLG|rcsb pdb:3DM2|rcsb pdb:3DMJ|rcsb pdb:3DOK|rcsb pdb:3DOL|rcsb pdb:3DOX|rcsb pdb:3DRP|rcsb pdb:3DRR|rcsb pdb:3DRS|rcsb pdb:3DYA|rcsb pdb:3E01|rcsb pdb:3FFI|rcsb pdb:3I0R|rcsb pdb:3I0S|rcsb pdb:3KJV|rcsb pdb:3KK1|rcsb pdb:3KK2|rcsb pdb:3KK3|rcsb pdb:3KT2|rcsb pdb:3KT5|rcsb pdb:3LAK|rcsb pdb:3LAL|rcsb pdb:3LAM|rcsb pdb:3LAN|rcsb pdb:3LP0|rcsb pdb:3LP1|rcsb pdb:3LP2|rcsb pdb:3M8P|rcsb pdb:3M8Q|rcsb pdb:3MEC|rcsb pdb:3MED|rcsb pdb:3MEE|rcsb pdb:3MEG|rcsb pdb:3N3I|rcsb pdb:3NBP|rcsb pdb:3PHV|rcsb pdb:3QIN|rcsb pdb:3QIO|rcsb pdb:3QIP|rcsb pdb:4U7Q|rcsb pdb:4U7V|rcsb pdb:5DGU|rcsb pdb:5DGW|rcsb pdb:4Q5M|rcsb pdb:4Q1W|rcsb pdb:4Q1X|rcsb pdb:4Q1Y|rcsb pdb:3T19|rcsb pdb:3T1A|rcsb pdb:3TAM|interpro:IPR034170|rcsb pdb:5HRN|rcsb pdb:5HRP|rcsb pdb:5HRR|rcsb pdb:5HRS|rcsb pdb:2YNF|rcsb pdb:2YNG|rcsb pdb:2YNH|rcsb pdb:2YNI|rcsb pdb:4B3O|rcsb pdb:4B3P|rcsb pdb:4B3Q|rcsb pdb:6SLU|rcsb pdb:6SMU|rcsb pdb:6WPF|rcsb pdb:6WPH|rcsb pdb:6WPJ|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:4KV8|rcsb pdb:4NCG|rcsb pdb:5YRS|rcsb pdb:5EU7|rcsb pdb:5J2M|rcsb pdb:5J2N|rcsb pdb:5J2P|rcsb pdb:5J2Q|rcsb pdb:5K14|rcsb pdb:6DIF|rcsb pdb:6DIL|rcsb pdb:6DJ1|rcsb pdb:6DJ2|rcsb pdb:6DJ5|rcsb pdb:6DJ7|rcsb pdb:6DV0|rcsb pdb:6DV4|rcsb pdb:6E7J|rcsb pdb:6E9A|rcsb pdb:6EWA|rcsb pdb:5T82|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5VZ6|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:5KAO|rcsb pdb:5TC2|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6EX9|rcsb pdb:6GL1|interpro:IPR043502|rcsb pdb:6OR7|rcsb pdb:6OTZ|rcsb pdb:6P1I|rcsb pdb:6P1X|rcsb pdb:6P2G|rcsb pdb:6J1V|rcsb pdb:6J1W|rcsb pdb:6PYL|rcsb pdb:6UIR|rcsb pdb:6UIS|rcsb pdb:6UIT|rcsb pdb:6UJX|rcsb pdb:6UJY|rcsb pdb:6UJZ|rcsb pdb:6UK0|interpro:IPR043128|rcsb pdb:6WAZ|rcsb pdb:6WB1|rcsb pdb:6VPZ|rcsb pdb:6VQ2|rcsb pdb:6VQD|rcsb pdb:6VQE|rcsb pdb:6VQY|rcsb pdb:6VQZ|mint:MINT-8055899(identity) refseq:NP_001304827.1|refseq:NP_001304829.1|refseq:NP_001121689.1|refseq:NP_066967.3|refseq:NP_150091.2|dip:DIP-46656N|ensembl:ENSG00000164985(gene)|ensembl:ENST00000380733(transcript)|ensembl:ENST00000380738(transcript)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009408"(response to heat)|go:"GO:0034399"(nuclear periphery)|go:"GO:0035327"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000313(PWWP)|interpro:IPR021567|interpro:IPR035441|interpro:IPR035496|interpro:IPR036218|mint:O75475|rcsb pdb:1Z9E|rcsb pdb:2B4J|rcsb pdb:2M16|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2N3A|rcsb pdb:3F9K|rcsb pdb:3HPG|rcsb pdb:3HPH|rcsb pdb:3U88|rcsb pdb:3ZEH|rcsb pdb:4FU6|rcsb pdb:5N88|rcsb pdb:5OYM|rcsb pdb:5YI9|rcsb pdb:6EMO|rcsb pdb:6EMP|rcsb pdb:6EMQ|rcsb pdb:6EMR|rcsb pdb:6S01|rcsb pdb:6TRJ|rcsb pdb:6TVM|rcsb pdb:6Z2Y|reactome:R-HSA-162592|reactome:R-HSA-164843|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|mint:MINT-8055905(identity) - - - figure legend:t2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/11/04 2014/10/16 rogid:u6ILy1OqEN0XGgqPgtqvSZdLs/A11706 rogid:MRtOw4kH/FxVku25dO5RQiNTjDA9606 intact-crc:A460EA5D99284426|rigid:8SNUoG3BxkzZIpj6DbpnH/gwuDM false binding-associated region:42-56(MINT-8055900)|polyprotein fragment:1148-1435(MINT-8055902) binding-associated region:401-413(MINT-8055906)|biotin tag:?-?(MINT-8055908) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0411"(enzyme linked immunosorbent assay)