#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q61471 uniprotkb:P57737 intact:EBI-8527498|intact:UNK-5461947|uniprotkb:Q640M3|ensembl:ENSMUSP00000036039 intact:EBI-6916167|uniprotkb:B4DFD6|uniprotkb:B4DL18|uniprotkb:I3L416|uniprotkb:Q17RK4|intact:EBI-10981974|ensembl:ENSP00000251166|ensembl:ENSP00000482646 psi-mi:tob1_mouse(display_long)|uniprotkb:Tob1(gene name)|psi-mi:Tob1(display_short)|uniprotkb:Tob(gene name synonym)|uniprotkb:Trob(gene name synonym)|uniprotkb:Transducer of erbB-2 1(gene name synonym) psi-mi:coro7_human(display_long)|uniprotkb:CORO7(gene name)|psi-mi:CORO7(display_short)|uniprotkb:70 kDa WD repeat tumor rejection antigen homolog(gene name synonym) psi-mi:"MI:0018"(two hybrid) Watanabe et al. (2011) mint:MINT-8074842|pubmed:21130766|mint:d-10-01541|doi:10.1016/j.febslet.2010.11.049 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8527494|mint:MINT-8075804 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033453.2|ensembl:ENSMUSG00000037573(gene)|ensembl:ENSMUST00000041589(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0060212"("negative regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|interpro:IPR002087(Anti-proliferative protein)|interpro:IPR015676(Transducer of ErbB-2)|interpro:IPR015677(Transducer of ErbB-2, 1)|interpro:IPR036054|mint:MINT-8075806(identity) refseq:NP_001188401.1|refseq:NP_001188402.1|refseq:NP_078811.3|ensembl:ENSG00000282725(gene)|ensembl:ENST00000251166(transcript)|ensembl:ENST00000614702(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003779"(actin binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0051015"(actin filament binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR027331|interpro:IPR036322|ensembl:ENSG00000262246(gene)|mint:MINT-8075807(identity) - comment:mint|function:Anti-proliferative protein that interacts with the erbB-2 receptor tyrosine kinase. May physically and/or functionally interact with protein-tyrosine kinase receptors - figure legend:f1a|comment:mint taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2010/11/29 2014/10/16 rogid:0EHniJDq4njxiw5LxYg5ttuWWeY10090 rogid:+SqObkzP4+y0Hq7oMaZqyNOKUKs9606 intact-crc:5D41B60FCEF1A387|rigid:PjTA5+fM5YNOaGhRpfq1ujoOaJ0 false fusion protein:?-?(MINT-8075814)|binding-associated region:2-236(MINT-8075817) fusion protein:?-?(MINT-8075829)|binding-associated region:584-925(MINT-8075959) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P57737 uniprotkb:Q15370 intact:EBI-6916167|uniprotkb:B4DFD6|uniprotkb:B4DL18|uniprotkb:I3L416|uniprotkb:Q17RK4|intact:EBI-10981974|ensembl:ENSP00000251166|ensembl:ENSP00000482646 intact:EBI-301238|ensembl:ENSP00000386652|uniprotkb:B7WPD3 psi-mi:coro7_human(display_long)|uniprotkb:CORO7(gene name)|psi-mi:CORO7(display_short)|uniprotkb:70 kDa WD repeat tumor rejection antigen homolog(gene name synonym) psi-mi:elob_human(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Watanabe et al. (2011) mint:MINT-8074842|pubmed:21130766|mint:d-10-01541|doi:10.1016/j.febslet.2010.11.049 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8527560|mint:MINT-8076005 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001188401.1|refseq:NP_001188402.1|refseq:NP_078811.3|ensembl:ENSG00000282725(gene)|ensembl:ENST00000251166(transcript)|ensembl:ENST00000614702(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003779"(actin binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0051015"(actin filament binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR027331|interpro:IPR036322|ensembl:ENSG00000262246(gene)|mint:MINT-8076011(identity) ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070449"(elongin complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR039049|mint:Q15370|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2JZ3|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFY|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:4WQO|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|rcsb pdb:6SIS|refseq:NP_009039.1|refseq:NP_996896.1|dip:DIP-29570N|mint:MINT-8076007(identity) - - - figure legend:f3d|comment:homomint|comment:mint taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2010/11/29 2014/10/16 rogid:+SqObkzP4+y0Hq7oMaZqyNOKUKs9606 rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606 intact-crc:A3FC76A435BDB25A|rigid:njrfewBfYwZELsgCt8khtlTzYyA false - flag tag:?-?(MINT-8076008) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q15369 uniprotkb:P57737 intact:EBI-301231|uniprotkb:Q567Q6|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121|uniprotkb:E5RGD9 intact:EBI-6916167|uniprotkb:B4DFD6|uniprotkb:B4DL18|uniprotkb:I3L416|uniprotkb:Q17RK4|intact:EBI-10981974|ensembl:ENSP00000251166|ensembl:ENSP00000482646 psi-mi:eloc_human(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym) psi-mi:coro7_human(display_long)|uniprotkb:CORO7(gene name)|psi-mi:CORO7(display_short)|uniprotkb:70 kDa WD repeat tumor rejection antigen homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Watanabe et al. (2011) mint:MINT-8074842|pubmed:21130766|mint:d-10-01541|doi:10.1016/j.febslet.2010.11.049 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8527574|mint:MINT-8076021 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005639.1|refseq:NP_001191786.1|refseq:NP_001191787.1|refseq:NP_001191788.1|refseq:NP_001191789.1|refseq:NP_001191790.1|refseq:NP_001191791.1|refseq:NP_001191792.1|refseq:NP_001191793.1|ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0070449"(elongin complex)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR039948|mint:Q15369|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|ensembl:ENST00000622804(transcript)|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:4WQO|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:6HAX|rcsb pdb:6GFY|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7N|rcsb pdb:6SIS|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-167200|refseq:XP_011515882.1|refseq:XP_011515883.1|dip:DIP-29571N|mint:MINT-8076025(identity) refseq:NP_001188401.1|refseq:NP_001188402.1|refseq:NP_078811.3|ensembl:ENSG00000282725(gene)|ensembl:ENST00000251166(transcript)|ensembl:ENST00000614702(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003779"(actin binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0051015"(actin filament binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR027331|interpro:IPR036322|ensembl:ENSG00000262246(gene)|mint:MINT-8076023(identity) - - - figure legend:f3d|comment:homomint|comment:mint taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2010/11/29 2014/10/16 rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606 rogid:+SqObkzP4+y0Hq7oMaZqyNOKUKs9606 intact-crc:826BF590D868DBB4|rigid:jAx409I8ZRhQzE5ARXu3h/dt7Sc false flag tag:?-?(MINT-8076026) - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q61471 uniprotkb:P57737 intact:EBI-8527498|intact:UNK-5461947|uniprotkb:Q640M3|ensembl:ENSMUSP00000036039 intact:EBI-6916167|uniprotkb:B4DFD6|uniprotkb:B4DL18|uniprotkb:I3L416|uniprotkb:Q17RK4|intact:EBI-10981974|ensembl:ENSP00000251166|ensembl:ENSP00000482646 psi-mi:tob1_mouse(display_long)|uniprotkb:Tob1(gene name)|psi-mi:Tob1(display_short)|uniprotkb:Tob(gene name synonym)|uniprotkb:Trob(gene name synonym)|uniprotkb:Transducer of erbB-2 1(gene name synonym) psi-mi:coro7_human(display_long)|uniprotkb:CORO7(gene name)|psi-mi:CORO7(display_short)|uniprotkb:70 kDa WD repeat tumor rejection antigen homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Watanabe et al. (2011) mint:MINT-8074842|pubmed:21130766|mint:d-10-01541|doi:10.1016/j.febslet.2010.11.049 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8527541|mint:MINT-8075962 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033453.2|ensembl:ENSMUSG00000037573(gene)|ensembl:ENSMUST00000041589(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0060212"("negative regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|interpro:IPR002087(Anti-proliferative protein)|interpro:IPR015676(Transducer of ErbB-2)|interpro:IPR015677(Transducer of ErbB-2, 1)|interpro:IPR036054|mint:MINT-8075964(identity) refseq:NP_001188401.1|refseq:NP_001188402.1|refseq:NP_078811.3|ensembl:ENSG00000282725(gene)|ensembl:ENST00000251166(transcript)|ensembl:ENST00000614702(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003779"(actin binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0051015"(actin filament binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR027331|interpro:IPR036322|ensembl:ENSG00000262246(gene)|mint:MINT-8075970(identity) - comment:mint|function:Anti-proliferative protein that interacts with the erbB-2 receptor tyrosine kinase. May physically and/or functionally interact with protein-tyrosine kinase receptors - comment:mint|figure legend:f1b f1c f2c taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2010/11/29 2014/10/16 rogid:0EHniJDq4njxiw5LxYg5ttuWWeY10090 rogid:+SqObkzP4+y0Hq7oMaZqyNOKUKs9606 intact-crc:0DD6F76375252690|rigid:PjTA5+fM5YNOaGhRpfq1ujoOaJ0 false myc tag:?-?(MINT-8075967) binding-associated region:584-925(MINT-8075973)|flag tag:?-?(MINT-8075971) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P49427 uniprotkb:P57737 intact:EBI-975634|ensembl:ENSP00000215574|uniprotkb:A8K689 intact:EBI-6916167|uniprotkb:B4DFD6|uniprotkb:B4DL18|uniprotkb:I3L416|uniprotkb:Q17RK4|intact:EBI-10981974|ensembl:ENSP00000251166|ensembl:ENSP00000482646 psi-mi:ub2r1_human(display_long)|uniprotkb:Ubiquitin-protein ligase R1(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-32 kDa complementing(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-CDC34(gene name synonym)|uniprotkb:CDC34(gene name)|psi-mi:CDC34(display_short)|uniprotkb:UBE2R1(gene name synonym)|uniprotkb:UBCH3(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme R1"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme R1(gene name synonym) psi-mi:coro7_human(display_long)|uniprotkb:CORO7(gene name)|psi-mi:CORO7(display_short)|uniprotkb:70 kDa WD repeat tumor rejection antigen homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Watanabe et al. (2011) mint:MINT-8074842|pubmed:21130766|mint:d-10-01541|doi:10.1016/j.febslet.2010.11.049 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8527602|mint:MINT-8076046 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070848"(response to growth factor)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090261"(positive regulation of inclusion body assembly)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:2OB4|rcsb pdb:3RZ3|rcsb pdb:4MDK|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-5607764|reactome:R-HSA-8866652|reactome:R-HSA-983168|ensembl:ENSG00000099804(gene)|ensembl:ENST00000215574(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|refseq:NP_004350.1|dip:DIP-37783N|mint:MINT-8076050(identity) refseq:NP_001188401.1|refseq:NP_001188402.1|refseq:NP_078811.3|ensembl:ENSG00000282725(gene)|ensembl:ENST00000251166(transcript)|ensembl:ENST00000614702(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003779"(actin binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0051015"(actin filament binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR027331|interpro:IPR036322|ensembl:ENSG00000262246(gene)|mint:MINT-8076048(identity) - - - figure legend:f3b|comment:homomint|comment:mint taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2010/11/29 2014/10/16 rogid:iOYLaiXBmINnd0daIWCr5KVungo9606 rogid:+SqObkzP4+y0Hq7oMaZqyNOKUKs9606 intact-crc:23684D0965879163|rigid:UH8NPJ1tIfOBe7YKyrdUUrvYujI false flag tag:?-?(MINT-8076051) - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P62877 uniprotkb:P57737 intact:EBI-398523|uniprotkb:Q8N6Z8|uniprotkb:Q9D1S2|uniprotkb:Q9WUK9|uniprotkb:Q9Y254|uniprotkb:B2RDY1|ensembl:ENSP00000216225 intact:EBI-6916167|uniprotkb:B4DFD6|uniprotkb:B4DL18|uniprotkb:I3L416|uniprotkb:Q17RK4|intact:EBI-10981974|ensembl:ENSP00000251166|ensembl:ENSP00000482646 psi-mi:rbx1_human(display_long)|uniprotkb:RBX1(gene name)|psi-mi:RBX1(display_short)|uniprotkb:RNF75(gene name synonym)|uniprotkb:ROC1(gene name synonym)|uniprotkb:Regulator of cullins 1(gene name synonym)|uniprotkb:RING finger protein 75(gene name synonym)|uniprotkb:Protein ZYP(gene name synonym)|uniprotkb:RING-box protein 1(gene name synonym)|uniprotkb:E3 ubiquitin-protein transferase RBX1(gene name synonym) psi-mi:coro7_human(display_long)|uniprotkb:CORO7(gene name)|psi-mi:CORO7(display_short)|uniprotkb:70 kDa WD repeat tumor rejection antigen homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Watanabe et al. (2011) mint:MINT-8074842|pubmed:21130766|mint:d-10-01541|doi:10.1016/j.febslet.2010.11.049 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8527616|mint:MINT-8076057 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055063.1|dip:DIP-17014N|ensembl:ENSG00000100387(gene)|ensembl:ENST00000216225(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019788"(NEDD8 transferase activity)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR024766|mint:P62877|rcsb pdb:1LDJ|rcsb pdb:1LDK|rcsb pdb:1U6G|rcsb pdb:2HYE|rcsb pdb:2LGV|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:3RTR|rcsb pdb:4F52|rcsb pdb:4P5O|rcsb pdb:5N4W|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5S|reactome:R-HSA-110314|reactome:R-HSA-1170546|reactome:R-HSA-1234176|reactome:R-HSA-180585|reactome:R-HSA-195253|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-4641258|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-68949|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|mint:MINT-8076061(identity) refseq:NP_001188401.1|refseq:NP_001188402.1|refseq:NP_078811.3|ensembl:ENSG00000282725(gene)|ensembl:ENST00000251166(transcript)|ensembl:ENST00000614702(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003779"(actin binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0051015"(actin filament binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR027331|interpro:IPR036322|ensembl:ENSG00000262246(gene)|mint:MINT-8076059(identity) - - - figure legend:f3b|comment:homomint|comment:mint taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2010/11/29 2014/10/16 rogid:pSaSNRZo+QudTPXOLUlksOj3smM9606 rogid:+SqObkzP4+y0Hq7oMaZqyNOKUKs9606 intact-crc:3CC129101204C346|rigid:JKDiaUOuvGcp8Sn0zn215Ww1RUI false flag tag:?-?(MINT-8076062) - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P57737 uniprotkb:Q13616 intact:EBI-6916167|uniprotkb:B4DFD6|uniprotkb:B4DL18|uniprotkb:I3L416|uniprotkb:Q17RK4|intact:EBI-10981974|ensembl:ENSP00000251166|ensembl:ENSP00000482646 intact:EBI-359390|uniprotkb:O60719|uniprotkb:Q08AL6|uniprotkb:Q8IYW1|uniprotkb:D3DWG3|ensembl:ENSP00000326804|ensembl:ENSP00000387160|ensembl:ENSP00000473318|ensembl:ENSP00000499255|ensembl:ENSP00000499277|ensembl:ENSP00000499398 psi-mi:coro7_human(display_long)|uniprotkb:CORO7(gene name)|psi-mi:CORO7(display_short)|uniprotkb:70 kDa WD repeat tumor rejection antigen homolog(gene name synonym) psi-mi:cul1_human(display_long)|uniprotkb:CUL1(gene name)|psi-mi:CUL1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Watanabe et al. (2011) mint:MINT-8074842|pubmed:21130766|mint:d-10-01541|doi:10.1016/j.febslet.2010.11.049 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8527588|mint:MINT-8076031 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001188401.1|refseq:NP_001188402.1|refseq:NP_078811.3|ensembl:ENSG00000282725(gene)|ensembl:ENST00000251166(transcript)|ensembl:ENST00000614702(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003779"(actin binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0051015"(actin filament binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR027331|interpro:IPR036322|ensembl:ENSG00000262246(gene)|mint:MINT-8076033(identity) refseq:NP_003583.2|rcsb pdb:6WCQ|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5R|rcsb pdb:7B5S|reactome:R-HSA-1169091|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|refseq:XP_011514931.1|refseq:XP_011514932.1|refseq:XP_011514933.1|refseq:XP_011514934.1|ensembl:ENSG00000055130(gene)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|ensembl:ENST00000325222(transcript)|ensembl:ENST00000409469(transcript)|ensembl:ENST00000602748(transcript)|ensembl:ENST00000662716(transcript)|ensembl:ENST00000663044(transcript)|ensembl:ENST00000665936(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13616|rcsb pdb:1LDJ|rcsb pdb:1LDK|rcsb pdb:1U6G|rcsb pdb:3RTR|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4F52|rcsb pdb:4P5O|rcsb pdb:5V89|rcsb pdb:6TTU|refseq:XP_005250117.1|dip:DIP-17013N|mint:MINT-8076035(identity) - - - figure legend:f3a|comment:homomint|comment:mint taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2010/11/29 2014/10/16 rogid:+SqObkzP4+y0Hq7oMaZqyNOKUKs9606 rogid:OAZP+ifWW3eEnQKb937ww9s1fMQ9606 intact-crc:A04373CF7CCA7121|rigid:vrQf1u+wEy9NgutPOJoA8GxrlrM false - flag tag:?-?(MINT-8076036) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q61471 uniprotkb:P57737 intact:EBI-8527498|intact:UNK-5461947|uniprotkb:Q640M3|ensembl:ENSMUSP00000036039 intact:EBI-6916167|uniprotkb:B4DFD6|uniprotkb:B4DL18|uniprotkb:I3L416|uniprotkb:Q17RK4|intact:EBI-10981974|ensembl:ENSP00000251166|ensembl:ENSP00000482646 psi-mi:tob1_mouse(display_long)|uniprotkb:Tob1(gene name)|psi-mi:Tob1(display_short)|uniprotkb:Tob(gene name synonym)|uniprotkb:Trob(gene name synonym)|uniprotkb:Transducer of erbB-2 1(gene name synonym) psi-mi:coro7_human(display_long)|uniprotkb:CORO7(gene name)|psi-mi:CORO7(display_short)|uniprotkb:70 kDa WD repeat tumor rejection antigen homolog(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Watanabe et al. (2011) mint:MINT-8074842|pubmed:21130766|mint:d-10-01541|doi:10.1016/j.febslet.2010.11.049 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-8527645|mint:MINT-8075984 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033453.2|ensembl:ENSMUSG00000037573(gene)|ensembl:ENSMUST00000041589(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0046332"(SMAD binding)|go:"GO:0060212"("negative regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|interpro:IPR002087(Anti-proliferative protein)|interpro:IPR015676(Transducer of ErbB-2)|interpro:IPR015677(Transducer of ErbB-2, 1)|interpro:IPR036054|mint:MINT-8075986(identity) refseq:NP_001188401.1|refseq:NP_001188402.1|refseq:NP_078811.3|ensembl:ENSG00000282725(gene)|ensembl:ENST00000251166(transcript)|ensembl:ENST00000614702(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003779"(actin binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0051015"(actin filament binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR027331|interpro:IPR036322|ensembl:ENSG00000262246(gene)|mint:MINT-8075990(identity) go:"GO:0005737"(cytoplasm) comment:mint|function:Anti-proliferative protein that interacts with the erbB-2 receptor tyrosine kinase. May physically and/or functionally interact with protein-tyrosine kinase receptors - figure legend:f1d|comment:mint taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2010/11/29 2014/10/16 rogid:0EHniJDq4njxiw5LxYg5ttuWWeY10090 rogid:+SqObkzP4+y0Hq7oMaZqyNOKUKs9606 intact-crc:B7DB208A52F04FE1|rigid:PjTA5+fM5YNOaGhRpfq1ujoOaJ0 false - flag tag:?-?(MINT-8075991) - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0707"(anti tag immunostaining)