#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P06729	uniprotkb:P59108	intact:EBI-3912464|uniprotkb:Q96TE5|ensembl:ENSP00000358490	intact:EBI-2642823|uniprotkb:Q8K1D7|ensembl:ENSMUSP00000045755	psi-mi:cd2_human(display_long)|uniprotkb:CD2(gene name)|psi-mi:CD2(display_short)|uniprotkb:SRBC(gene name synonym)|uniprotkb:Erythrocyte receptor(gene name synonym)|uniprotkb:LFA-2(gene name synonym)|uniprotkb:LFA-3 receptor(gene name synonym)|uniprotkb:Rosette receptor(gene name synonym)|uniprotkb:T-cell surface antigen T11/Leu-5(gene name synonym)	psi-mi:cpne2_mouse(display_long)|uniprotkb:Copine II(gene name synonym)|uniprotkb:Cpne2(gene name)|psi-mi:Cpne2(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Perestenko et al. (2010)	mint:MINT-8049157|pubmed:21087455|mint:fj-10-0593.r2|doi:10.1111/j.1742-4658.2010.07935	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8512711|mint:MINT-8049176	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001758.2|ensembl:ENST00000369478(transcript)|go:"GO:0001766"(membrane raft polarization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030887"(positive regulation of myeloid dendritic cell activation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015632(CD2)|interpro:IPR036179|mint:P06729|rcsb pdb:1CDB|rcsb pdb:1GYA|rcsb pdb:1HNF|rcsb pdb:1L2Z|rcsb pdb:1QA9|rcsb pdb:2J6O|rcsb pdb:2J7I|reactome:R-HSA-202733|ensembl:ENSG00000116824(gene)|refseq:NP_001315538.1|mint:MINT-8049178(identity)	refseq:NP_705727.1|ensembl:ENSMUSG00000034361(gene)|ensembl:ENSMUST00000048653(transcript)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR010734(Copine)|interpro:IPR035892|interpro:IPR036465|interpro:IPR037768|go:"GO:0071277"(cellular response to calcium ion)|mint:MINT-8049179(identity)	go:"GO:0005886"(plasma membrane)	-	-	figure legend:f3a|comment:homomint|comment:mint	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/10/21	2014/10/16	rogid:GN7E4kazkOZr2RuMuSMu5WGrbsE9606	rogid:yGpBarHzlgZXvt3AEX+5HbM/ACA10090	intact-crc:A575C54E74805271|rigid:yFtLsvzKNF617Ud1tk0YeGdb85w	false	-	myc tag:?-?(MINT-8049185)	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q9Z140	uniprotkb:P02787	intact:EBI-8316955|intact:MINT-4091900|ensembl:ENSMUSP00000073847|ensembl:ENSMUSP00000126493|ensembl:ENSMUSP00000128555	intact:EBI-714319|uniprotkb:O43890|uniprotkb:Q9NQB8|uniprotkb:Q9UHV0|uniprotkb:Q1HBA5|ensembl:ENSP00000385834	psi-mi:cpne6_mouse(display_long)|uniprotkb:Cpne6(gene name)|psi-mi:Cpne6(display_short)|uniprotkb:Copine VI(gene name synonym)|uniprotkb:Neuronal-copine(gene name synonym)	psi-mi:trfe_human(display_long)|uniprotkb:Siderophilin(gene name synonym)|uniprotkb:Beta-1 metal-binding globulin(gene name synonym)|uniprotkb:TF(gene name)|psi-mi:TF(display_short)|uniprotkb:PRO1400(orf name)	psi-mi:"MI:0416"(fluorescence microscopy)	Perestenko et al. (2010)	mint:MINT-8049157|pubmed:21087455|mint:fj-10-0593.r2|doi:10.1111/j.1742-4658.2010.07935	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8512746|mint:MINT-8049236	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129529.1|refseq:NP_034077.1|refseq:XP_006518569.1|ensembl:ENSMUSG00000022212(gene)|ensembl:ENSMUST00000074225(transcript)|ensembl:ENSMUST00000163767(transcript)|ensembl:ENSMUST00000171643(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0046872"(metal ion binding)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR010734(Copine)|interpro:IPR035892|interpro:IPR036465|interpro:IPR037768|mint:Q9Z140|reactome:R-MMU-1483206|mint:MINT-8049238(identity)	refseq:NP_001054.1|rcsb pdb:1JQF|rcsb pdb:1N7W|rcsb pdb:1N7X|rcsb pdb:1N84|rcsb pdb:1OQG|rcsb pdb:1OQH|rcsb pdb:1RYO|rcsb pdb:1SUV|rcsb pdb:2HAU|rcsb pdb:2HAV|rcsb pdb:2O7U|rcsb pdb:2O84|rcsb pdb:3FGS|rcsb pdb:3QYT|rcsb pdb:3S9L|rcsb pdb:3S9M|rcsb pdb:1FQF|rcsb pdb:3S9N|rcsb pdb:3SKP|rcsb pdb:3V83|rcsb pdb:3V89|rcsb pdb:3V8X|rcsb pdb:4H0W|rcsb pdb:4X1B|rcsb pdb:4X1D|rcsb pdb:5DYH|rcsb pdb:5H52|rcsb pdb:5WTD|rcsb pdb:5X5P|rcsb pdb:5Y6K|rcsb pdb:6CTC|rcsb pdb:6D03|rcsb pdb:6D04|rcsb pdb:6D05|rcsb pdb:3VE1|rcsb pdb:6JAS|rcsb pdb:6SOY|rcsb pdb:6SOZ|rcsb pdb:6UJ6|reactome:R-HSA-114608|reactome:R-HSA-381426|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8957275|reactome:R-HSA-917937|reactome:R-HSA-917977|go:"GO:0034986"(iron chaperone activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0045178"(basal part of cell)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071281"(cellular response to iron ion)|go:"GO:0072562"(blood microparticle)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000147"(positive regulation of cell motility)|interpro:IPR001156(Peptidase S60, transferrin lactoferrin)|interpro:IPR016357(Transferrin)|interpro:IPR018195|interpro:IPR030685|mint:P02787|rcsb pdb:1A8E|go:"GO:0034774"(secretory granule lumen)|rcsb pdb:1A8F|rcsb pdb:1B3E|rcsb pdb:1BP5|rcsb pdb:1BTJ|rcsb pdb:1D3K|rcsb pdb:1D4N|rcsb pdb:1DTG|rcsb pdb:1FQE|ensembl:ENSG00000091513(gene)|ensembl:ENST00000402696(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007015"(actin filament organization)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008199"(ferric iron binding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031982"(vesicle)|go:"GO:0034756"(regulation of iron ion transport)|refseq:XP_016862578.1|refseq:XP_016862579.1|dip:DIP-2738N|mint:MINT-8049239(identity)	go:"GO:0031410"(cytoplasmic vesicle)	comment:mint|function:"May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties (By similarity). May have a role in synaptic plasticity"	-	comment:homomint|comment:mint|figure legend:f7a1	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/10/21	2014/10/16	rogid:lKxOW3m956QPbiLMVdDaCnMkBu410090	rogid:CN9nME9TVV6/FGrhH6XHtJF9/HI9606	intact-crc:E208DBE52C1ACA14|rigid:sstA7DEXPHbLcE0fUjMZkKjResA	false	yellow fluorescent protein tag:?-?(MINT-8049244)	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0422"(immunostaining)