#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q08109	uniprotkb:Q08109	intact:EBI-37613|uniprotkb:D6W254|ensemblfungi:YOL013C	intact:EBI-37613|uniprotkb:D6W254|ensemblfungi:YOL013C	psi-mi:hrd1_yeast(display_long)|uniprotkb:HMG-CoA reductase degradation protein 1(gene name synonym)|uniprotkb:HRD1(gene name)|psi-mi:HRD1(display_short)|uniprotkb:DER3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HRD1(gene name synonym)|uniprotkb:YOL013C(locus name)	psi-mi:hrd1_yeast(display_long)|uniprotkb:HMG-CoA reductase degradation protein 1(gene name synonym)|uniprotkb:HRD1(gene name)|psi-mi:HRD1(display_short)|uniprotkb:DER3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HRD1(gene name synonym)|uniprotkb:YOL013C(locus name)	psi-mi:"MI:0030"(cross-linking study)	Carvalho et al. (2010)	pubmed:21074049|imex:IM-15200	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2945809|imex:IM-15200-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014630.1|sgd:S000005373|dip:DIP-8850N|mint:Q08109|ensemblfungi:YOL013C(gene)|ensemblfungi:YOL013C_mRNA(transcript)|go:"GO:0000838"(Hrd1p ubiquitin ligase ERAD-M complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR032832|rcsb pdb:5V6P|rcsb pdb:6VJY|rcsb pdb:6VJZ|rcsb pdb:6VK0|rcsb pdb:6VK1|reactome:R-SCE-5358346	refseq:NP_014630.1|sgd:S000005373|dip:DIP-8850N|mint:Q08109|ensemblfungi:YOL013C(gene)|ensemblfungi:YOL013C_mRNA(transcript)|go:"GO:0000838"(Hrd1p ubiquitin ligase ERAD-M complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR032832|rcsb pdb:5V6P|rcsb pdb:6VJY|rcsb pdb:6VJZ|rcsb pdb:6VK0|rcsb pdb:6VK1|reactome:R-SCE-5358346	psi-mi:"MI:0469"(intact)	-	-	comment:Interaction greatly reduced in usa-/- cells|comment:When proteins are crosslinked, oligomers form.|figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/11/25	2014/10/16	rogid:3ZN9xobcUi6DPqnKgASUmdGL/3g559292	rogid:3ZN9xobcUi6DPqnKgASUmdGL/3g559292	intact-crc:48473F2C5300A184|rigid:GBEXzJY4BO0q1PAiP93MlZWUT7o	false	ha tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q08109	uniprotkb:Q08109	intact:EBI-37613|uniprotkb:D6W254|ensemblfungi:YOL013C	intact:EBI-37613|uniprotkb:D6W254|ensemblfungi:YOL013C	psi-mi:hrd1_yeast(display_long)|uniprotkb:HMG-CoA reductase degradation protein 1(gene name synonym)|uniprotkb:HRD1(gene name)|psi-mi:HRD1(display_short)|uniprotkb:DER3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HRD1(gene name synonym)|uniprotkb:YOL013C(locus name)	psi-mi:hrd1_yeast(display_long)|uniprotkb:HMG-CoA reductase degradation protein 1(gene name synonym)|uniprotkb:HRD1(gene name)|psi-mi:HRD1(display_short)|uniprotkb:DER3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HRD1(gene name synonym)|uniprotkb:YOL013C(locus name)	psi-mi:"MI:0030"(cross-linking study)	Carvalho et al. (2010)	pubmed:21074049|imex:IM-15200	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2946484|imex:IM-15200-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014630.1|sgd:S000005373|dip:DIP-8850N|mint:Q08109|ensemblfungi:YOL013C(gene)|ensemblfungi:YOL013C_mRNA(transcript)|go:"GO:0000838"(Hrd1p ubiquitin ligase ERAD-M complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR032832|rcsb pdb:5V6P|rcsb pdb:6VJY|rcsb pdb:6VJZ|rcsb pdb:6VK0|rcsb pdb:6VK1|reactome:R-SCE-5358346	refseq:NP_014630.1|sgd:S000005373|dip:DIP-8850N|mint:Q08109|ensemblfungi:YOL013C(gene)|ensemblfungi:YOL013C_mRNA(transcript)|go:"GO:0000838"(Hrd1p ubiquitin ligase ERAD-M complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR032832|rcsb pdb:5V6P|rcsb pdb:6VJY|rcsb pdb:6VJZ|rcsb pdb:6VK0|rcsb pdb:6VK1|reactome:R-SCE-5358346	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/11/25	2014/10/16	rogid:3ZN9xobcUi6DPqnKgASUmdGL/3g559292	rogid:3ZN9xobcUi6DPqnKgASUmdGL/3g559292	intact-crc:5B6BB13FF836ABA9|rigid:z4fveLdU3FZGxe92eyZyWdWHQ2A	false	ha tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q08109	uniprotkb:Q03714	intact:EBI-37613|uniprotkb:D6W254|ensemblfungi:YOL013C	intact:EBI-27760|uniprotkb:D6VZE5|ensemblfungi:YML029W	psi-mi:hrd1_yeast(display_long)|uniprotkb:HMG-CoA reductase degradation protein 1(gene name synonym)|uniprotkb:HRD1(gene name)|psi-mi:HRD1(display_short)|uniprotkb:DER3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HRD1(gene name synonym)|uniprotkb:YOL013C(locus name)	psi-mi:usa1_yeast(display_long)|uniprotkb:USA1(gene name)|psi-mi:USA1(display_short)|uniprotkb:YML029W(locus name)	psi-mi:"MI:0030"(cross-linking study)	Carvalho et al. (2010)	pubmed:21074049|imex:IM-15200	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2946484|imex:IM-15200-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014630.1|sgd:S000005373|dip:DIP-8850N|mint:Q08109|ensemblfungi:YOL013C(gene)|ensemblfungi:YOL013C_mRNA(transcript)|go:"GO:0000838"(Hrd1p ubiquitin ligase ERAD-M complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR032832|rcsb pdb:5V6P|rcsb pdb:6VJY|rcsb pdb:6VJZ|rcsb pdb:6VK0|rcsb pdb:6VK1|reactome:R-SCE-5358346	refseq:NP_013683.1|sgd:S000004491|dip:DIP-6423N|mint:Q03714|ensemblfungi:YML029W(gene)|ensemblfungi:YML029W_mRNA(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|rcsb pdb:6VJZ|rcsb pdb:6VK0	psi-mi:"MI:0469"(intact)	-	crc64:9B93ECA6C5421FD6	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/11/25	2014/10/16	rogid:3ZN9xobcUi6DPqnKgASUmdGL/3g559292	rogid:k5/W6R8NnkOWchVSQSoXCbvaAZ8559292	intact-crc:5B6BB13FF836ABA9|rigid:z4fveLdU3FZGxe92eyZyWdWHQ2A	false	ha tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q08109	uniprotkb:Q08109	intact:EBI-37613|uniprotkb:D6W254|ensemblfungi:YOL013C	intact:EBI-37613|uniprotkb:D6W254|ensemblfungi:YOL013C	psi-mi:hrd1_yeast(display_long)|uniprotkb:HMG-CoA reductase degradation protein 1(gene name synonym)|uniprotkb:HRD1(gene name)|psi-mi:HRD1(display_short)|uniprotkb:DER3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HRD1(gene name synonym)|uniprotkb:YOL013C(locus name)	psi-mi:hrd1_yeast(display_long)|uniprotkb:HMG-CoA reductase degradation protein 1(gene name synonym)|uniprotkb:HRD1(gene name)|psi-mi:HRD1(display_short)|uniprotkb:DER3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HRD1(gene name synonym)|uniprotkb:YOL013C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Carvalho et al. (2010)	pubmed:21074049|imex:IM-15200	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2945860|imex:IM-15200-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014630.1|sgd:S000005373|dip:DIP-8850N|mint:Q08109|ensemblfungi:YOL013C(gene)|ensemblfungi:YOL013C_mRNA(transcript)|go:"GO:0000838"(Hrd1p ubiquitin ligase ERAD-M complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR032832|rcsb pdb:5V6P|rcsb pdb:6VJY|rcsb pdb:6VJZ|rcsb pdb:6VK0|rcsb pdb:6VK1|reactome:R-SCE-5358346	refseq:NP_014630.1|sgd:S000005373|dip:DIP-8850N|mint:Q08109|ensemblfungi:YOL013C(gene)|ensemblfungi:YOL013C_mRNA(transcript)|go:"GO:0000838"(Hrd1p ubiquitin ligase ERAD-M complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR032832|rcsb pdb:5V6P|rcsb pdb:6VJY|rcsb pdb:6VJZ|rcsb pdb:6VK0|rcsb pdb:6VK1|reactome:R-SCE-5358346	go:"GO:0042803"(protein homodimerization activity)	-	-	comment:"Interaction greatly reduced in usa-/- cells. Hrd1 (cys399ser) oligomerized even in the absence of Usa1."|figure legend:Figs. 2A, 2D, Supp. Fig. 3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/11/25	2014/10/16	rogid:3ZN9xobcUi6DPqnKgASUmdGL/3g559292	rogid:3ZN9xobcUi6DPqnKgASUmdGL/3g559292	intact-crc:1BA23D9F110ED37B|rigid:GBEXzJY4BO0q1PAiP93MlZWUT7o	false	myc tag:?-?|sufficient binding region:207-551,1-86	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q08109	uniprotkb:Q03714	intact:EBI-37613|uniprotkb:D6W254|ensemblfungi:YOL013C	intact:EBI-27760|uniprotkb:D6VZE5|ensemblfungi:YML029W	psi-mi:hrd1_yeast(display_long)|uniprotkb:HMG-CoA reductase degradation protein 1(gene name synonym)|uniprotkb:HRD1(gene name)|psi-mi:HRD1(display_short)|uniprotkb:DER3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HRD1(gene name synonym)|uniprotkb:YOL013C(locus name)	psi-mi:usa1_yeast(display_long)|uniprotkb:USA1(gene name)|psi-mi:USA1(display_short)|uniprotkb:YML029W(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Carvalho et al. (2010)	pubmed:21074049|imex:IM-15200	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2946431|imex:IM-15200-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014630.1|sgd:S000005373|dip:DIP-8850N|mint:Q08109|ensemblfungi:YOL013C(gene)|ensemblfungi:YOL013C_mRNA(transcript)|go:"GO:0000838"(Hrd1p ubiquitin ligase ERAD-M complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR032832|rcsb pdb:5V6P|rcsb pdb:6VJY|rcsb pdb:6VJZ|rcsb pdb:6VK0|rcsb pdb:6VK1|reactome:R-SCE-5358346	refseq:NP_013683.1|sgd:S000004491|dip:DIP-6423N|mint:Q03714|ensemblfungi:YML029W(gene)|ensemblfungi:YML029W_mRNA(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|rcsb pdb:6VJZ|rcsb pdb:6VK0	psi-mi:"MI:0469"(intact)	-	crc64:9B93ECA6C5421FD6	figure legend:Fig. 2B, Supp. Fig 3A|comment:Q03714  deletion 437-490  abolished both the binding of Usa1 to Hrd1 and the oligomerization of Hrd1, the region from 371 to 418 also appears  to be important for Hrd1p oligomerization.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/11/25	2014/10/16	rogid:3ZN9xobcUi6DPqnKgASUmdGL/3g559292	rogid:k5/W6R8NnkOWchVSQSoXCbvaAZ8559292	intact-crc:171F9454CE47ECA9|rigid:z4fveLdU3FZGxe92eyZyWdWHQ2A	false	ha tag:?-?	necessary binding region:437-490	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q08109	uniprotkb:Q08109	intact:EBI-37613|uniprotkb:D6W254|ensemblfungi:YOL013C	intact:EBI-37613|uniprotkb:D6W254|ensemblfungi:YOL013C	psi-mi:hrd1_yeast(display_long)|uniprotkb:HMG-CoA reductase degradation protein 1(gene name synonym)|uniprotkb:HRD1(gene name)|psi-mi:HRD1(display_short)|uniprotkb:DER3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HRD1(gene name synonym)|uniprotkb:YOL013C(locus name)	psi-mi:hrd1_yeast(display_long)|uniprotkb:HMG-CoA reductase degradation protein 1(gene name synonym)|uniprotkb:HRD1(gene name)|psi-mi:HRD1(display_short)|uniprotkb:DER3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HRD1(gene name synonym)|uniprotkb:YOL013C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Carvalho et al. (2010)	pubmed:21074049|imex:IM-15200	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2946431|imex:IM-15200-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014630.1|sgd:S000005373|dip:DIP-8850N|mint:Q08109|ensemblfungi:YOL013C(gene)|ensemblfungi:YOL013C_mRNA(transcript)|go:"GO:0000838"(Hrd1p ubiquitin ligase ERAD-M complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR032832|rcsb pdb:5V6P|rcsb pdb:6VJY|rcsb pdb:6VJZ|rcsb pdb:6VK0|rcsb pdb:6VK1|reactome:R-SCE-5358346	refseq:NP_014630.1|sgd:S000005373|dip:DIP-8850N|mint:Q08109|ensemblfungi:YOL013C(gene)|ensemblfungi:YOL013C_mRNA(transcript)|go:"GO:0000838"(Hrd1p ubiquitin ligase ERAD-M complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR032832|rcsb pdb:5V6P|rcsb pdb:6VJY|rcsb pdb:6VJZ|rcsb pdb:6VK0|rcsb pdb:6VK1|reactome:R-SCE-5358346	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2B, Supp. Fig 3A|comment:Q03714  deletion 437-490  abolished both the binding of Usa1 to Hrd1 and the oligomerization of Hrd1, the region from 371 to 418 also appears  to be important for Hrd1p oligomerization.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/11/25	2014/10/16	rogid:3ZN9xobcUi6DPqnKgASUmdGL/3g559292	rogid:3ZN9xobcUi6DPqnKgASUmdGL/3g559292	intact-crc:171F9454CE47ECA9|rigid:z4fveLdU3FZGxe92eyZyWdWHQ2A	false	ha tag:?-?	myc tag:?-?|sufficient binding region:1-86,207-551	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q03714	uniprotkb:Q03714	intact:EBI-27760|uniprotkb:D6VZE5|ensemblfungi:YML029W	intact:EBI-27760|uniprotkb:D6VZE5|ensemblfungi:YML029W	psi-mi:usa1_yeast(display_long)|uniprotkb:USA1(gene name)|psi-mi:USA1(display_short)|uniprotkb:YML029W(locus name)	psi-mi:usa1_yeast(display_long)|uniprotkb:USA1(gene name)|psi-mi:USA1(display_short)|uniprotkb:YML029W(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Carvalho et al. (2010)	pubmed:21074049|imex:IM-15200	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2946454|imex:IM-15200-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013683.1|sgd:S000004491|dip:DIP-6423N|mint:Q03714|ensemblfungi:YML029W(gene)|ensemblfungi:YML029W_mRNA(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|rcsb pdb:6VJZ|rcsb pdb:6VK0	refseq:NP_013683.1|sgd:S000004491|dip:DIP-6423N|mint:Q03714|ensemblfungi:YML029W(gene)|ensemblfungi:YML029W_mRNA(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|rcsb pdb:6VJZ|rcsb pdb:6VK0	psi-mi:"MI:0469"(intact)	crc64:9B93ECA6C5421FD6	crc64:9B93ECA6C5421FD6	figure legend:Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/11/25	2014/10/16	rogid:k5/W6R8NnkOWchVSQSoXCbvaAZ8559292	rogid:k5/W6R8NnkOWchVSQSoXCbvaAZ8559292	intact-crc:6517389DA4CB963F|rigid:4Qh/UdZ14K1PEzE6iSDttB/I1Os	false	ha tag:?-?|necessary binding region:371-418	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q08109	uniprotkb:P00729	intact:EBI-37613|uniprotkb:D6W254|ensemblfungi:YOL013C	intact:EBI-4153|uniprotkb:D6W0C4|ensemblfungi:YMR297W	psi-mi:hrd1_yeast(display_long)|uniprotkb:HMG-CoA reductase degradation protein 1(gene name synonym)|uniprotkb:HRD1(gene name)|psi-mi:HRD1(display_short)|uniprotkb:DER3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HRD1(gene name synonym)|uniprotkb:YOL013C(locus name)	psi-mi:cbpy_yeast(display_long)|uniprotkb:PRC1(gene name)|psi-mi:PRC1(display_short)|uniprotkb:YMR297W(locus name)|uniprotkb:Carboxypeptidase YSCY(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Carvalho et al. (2010)	pubmed:21074049|imex:IM-15200	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2946501|imex:IM-15200-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014630.1|sgd:S000005373|dip:DIP-8850N|mint:Q08109|ensemblfungi:YOL013C(gene)|ensemblfungi:YOL013C_mRNA(transcript)|go:"GO:0000838"(Hrd1p ubiquitin ligase ERAD-M complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR032832|rcsb pdb:5V6P|rcsb pdb:6VJY|rcsb pdb:6VJZ|rcsb pdb:6VK0|rcsb pdb:6VK1|reactome:R-SCE-5358346	refseq:NP_014026.1|sgd:S000004912|dip:DIP-2394N|mint:P00729|ensemblfungi:YMR297W(gene)|ensemblfungi:YMR297W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0004185"(serine-type carboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0016236"(macroautophagy)|go:"GO:0031638"(zymogen activation)|go:"GO:0046938"(phytochelatin biosynthetic process)|interpro:IPR001563(Peptidase S10, serine carboxypeptidase)|interpro:IPR008442(Propeptide, carboxypeptidase Y)|interpro:IPR018202|interpro:IPR029058|interpro:IPR033124|rcsb pdb:1CPY|rcsb pdb:1WPX|rcsb pdb:1YSC	psi-mi:"MI:0469"(intact)	-	crc64:7227F3489CBDD952	figure legend:Figs. 4A, 4B, 5A, 5B, 5C, 5D, 6A, 6B, Supp. Fig. 7A|comment:"Mutation of a glycosylation site (position not given) of Hrd1 reduced binding to PRC1. Interaction was also reduced in a OS9-/- cell line and absent in  cells expressing a fragment (residues 357 833) of the luminal domain of Hrd3p. Binding was also reduced in Der1-/- and Usa1-/- cells but retained in Usa1 deletion mutant clss provided region 437 490 of Usa1 was present."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/11/25	2014/10/16	rogid:3ZN9xobcUi6DPqnKgASUmdGL/3g559292	rogid:Bq8u8yxh+HsmVVY4WoyfKvmy928559292	intact-crc:22D8BFCB5BE3013B|rigid:+C9uxitlygy6ITLPYIK5TJg51Dc	false	myc tag:c-c|sufficient binding region:207-551,1-86|mutation decreasing interaction:399-399	ha tag:c-c|fusion protein:c-c|sufficient binding region:353-532	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q05787	uniprotkb:P00729	intact:EBI-31647|uniprotkb:D6VYK8|ensemblfungi:YLR207W	intact:EBI-4153|uniprotkb:D6W0C4|ensemblfungi:YMR297W	psi-mi:hrd3_yeast(display_long)|uniprotkb:HMG-CoA reductase degradation protein 3(gene name synonym)|uniprotkb:HRD3(gene name)|psi-mi:HRD3(display_short)|uniprotkb:YLR207W(locus name)	psi-mi:cbpy_yeast(display_long)|uniprotkb:PRC1(gene name)|psi-mi:PRC1(display_short)|uniprotkb:YMR297W(locus name)|uniprotkb:Carboxypeptidase YSCY(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Carvalho et al. (2010)	pubmed:21074049|imex:IM-15200	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2946513|imex:IM-15200-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013308.1|sgd:S000004197|dip:DIP-2843N|mint:Q05787|ensemblfungi:YLR207W(gene)|ensemblfungi:YLR207W_mRNA(transcript)|go:"GO:0000838"(Hrd1p ubiquitin ligase ERAD-M complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0034099"(luminal surveillance complex)|go:"GO:1905524"(negative regulation of protein autoubiquitination)|interpro:IPR006597(Sel1-like)|interpro:IPR011990(Tetratricopeptide-like helical)|rcsb pdb:5V7V|rcsb pdb:6VJY|rcsb pdb:6VJZ|rcsb pdb:6VK0|rcsb pdb:6VK1|rcsb pdb:6VK3|reactome:R-SCE-5358346	refseq:NP_014026.1|sgd:S000004912|dip:DIP-2394N|mint:P00729|ensemblfungi:YMR297W(gene)|ensemblfungi:YMR297W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0004185"(serine-type carboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0016236"(macroautophagy)|go:"GO:0031638"(zymogen activation)|go:"GO:0046938"(phytochelatin biosynthetic process)|interpro:IPR001563(Peptidase S10, serine carboxypeptidase)|interpro:IPR008442(Propeptide, carboxypeptidase Y)|interpro:IPR018202|interpro:IPR029058|interpro:IPR033124|rcsb pdb:1CPY|rcsb pdb:1WPX|rcsb pdb:1YSC	psi-mi:"MI:0469"(intact)	-	crc64:7227F3489CBDD952	figure legend:Fig. 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/11/25	2014/10/16	rogid:MCNT6LrWgeCYdL5VJmtrbEZR6j4559292	rogid:Bq8u8yxh+HsmVVY4WoyfKvmy928559292	intact-crc:E4281323BD79C7EB|rigid:GrTbI1gpL3qW2EzUNOWoyxSLT64	false	sufficient binding region:1-767|myc tag:c-c	ha tag:c-c|fusion protein:c-c|sufficient binding region:353-532	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P00729	uniprotkb:P38307	intact:EBI-4153|uniprotkb:D6W0C4|ensemblfungi:YMR297W	intact:EBI-5761|uniprotkb:D6VQJ8|ensemblfungi:YBR201W	psi-mi:cbpy_yeast(display_long)|uniprotkb:PRC1(gene name)|psi-mi:PRC1(display_short)|uniprotkb:YMR297W(locus name)|uniprotkb:Carboxypeptidase YSCY(gene name synonym)	psi-mi:der1_yeast(display_long)|uniprotkb:DER1(gene name)|psi-mi:DER1(display_short)|uniprotkb:YBR1413(orf name)|uniprotkb:YBR201W(locus name)	psi-mi:"MI:0030"(cross-linking study)	Carvalho et al. (2010)	pubmed:21074049|imex:IM-15200	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2946527|imex:IM-15200-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014026.1|sgd:S000004912|dip:DIP-2394N|mint:P00729|ensemblfungi:YMR297W(gene)|ensemblfungi:YMR297W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0004185"(serine-type carboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0016236"(macroautophagy)|go:"GO:0031638"(zymogen activation)|go:"GO:0046938"(phytochelatin biosynthetic process)|interpro:IPR001563(Peptidase S10, serine carboxypeptidase)|interpro:IPR008442(Propeptide, carboxypeptidase Y)|interpro:IPR018202|interpro:IPR029058|interpro:IPR033124|rcsb pdb:1CPY|rcsb pdb:1WPX|rcsb pdb:1YSC	refseq:NP_009760.1|sgd:S000000405|dip:DIP-4767N|mint:P38307|ensemblfungi:YBR201W(gene)|ensemblfungi:YBR201W_mRNA(transcript)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0070843"(misfolded protein transport)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR007599(Der1-like)|rcsb pdb:6VJZ|rcsb pdb:6VK0|reactome:R-SCE-5358346	psi-mi:"MI:0469"(intact)	crc64:7227F3489CBDD952	-	figure legend:Fig. 4D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/11/25	2014/10/16	rogid:Bq8u8yxh+HsmVVY4WoyfKvmy928559292	rogid:N7+WHcf3DTfyF3fU1FGDTAzuE7M559292	intact-crc:2C70B092A9A6251C|rigid:HU9Z7UKX/HahkRuDCB1bJPSFAWo	false	ha tag:c-c|fusion protein:c-c|sufficient binding region:353-532	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q08109	uniprotkb:P00729	intact:EBI-37613|uniprotkb:D6W254|ensemblfungi:YOL013C	intact:EBI-4153|uniprotkb:D6W0C4|ensemblfungi:YMR297W	psi-mi:hrd1_yeast(display_long)|uniprotkb:HMG-CoA reductase degradation protein 1(gene name synonym)|uniprotkb:HRD1(gene name)|psi-mi:HRD1(display_short)|uniprotkb:DER3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HRD1(gene name synonym)|uniprotkb:YOL013C(locus name)	psi-mi:cbpy_yeast(display_long)|uniprotkb:PRC1(gene name)|psi-mi:PRC1(display_short)|uniprotkb:YMR297W(locus name)|uniprotkb:Carboxypeptidase YSCY(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Carvalho et al. (2010)	pubmed:21074049|imex:IM-15200	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3134679|imex:IM-15200-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014630.1|sgd:S000005373|dip:DIP-8850N|mint:Q08109|ensemblfungi:YOL013C(gene)|ensemblfungi:YOL013C_mRNA(transcript)|go:"GO:0000838"(Hrd1p ubiquitin ligase ERAD-M complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR032832|rcsb pdb:5V6P|rcsb pdb:6VJY|rcsb pdb:6VJZ|rcsb pdb:6VK0|rcsb pdb:6VK1|reactome:R-SCE-5358346	refseq:NP_014026.1|sgd:S000004912|dip:DIP-2394N|mint:P00729|ensemblfungi:YMR297W(gene)|ensemblfungi:YMR297W_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0004185"(serine-type carboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0016236"(macroautophagy)|go:"GO:0031638"(zymogen activation)|go:"GO:0046938"(phytochelatin biosynthetic process)|interpro:IPR001563(Peptidase S10, serine carboxypeptidase)|interpro:IPR008442(Propeptide, carboxypeptidase Y)|interpro:IPR018202|interpro:IPR029058|interpro:IPR033124|rcsb pdb:1CPY|rcsb pdb:1WPX|rcsb pdb:1YSC	psi-mi:"MI:0469"(intact)	-	crc64:7227F3489CBDD952	figure legend:Figs. 4F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/11/25	2014/10/16	rogid:3ZN9xobcUi6DPqnKgASUmdGL/3g559292	rogid:Bq8u8yxh+HsmVVY4WoyfKvmy928559292	intact-crc:D6CE82A16300D724|rigid:+C9uxitlygy6ITLPYIK5TJg51Dc	false	necessary binding region:87-206|myc tag:c-c	ha tag:c-c|fusion protein:c-c|sufficient binding region:353-532	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q08109	uniprotkb:Q04228	intact:EBI-37613|uniprotkb:D6W254|ensemblfungi:YOL013C	intact:EBI-27730|uniprotkb:D6VZG1|ensemblfungi:YML013W	psi-mi:hrd1_yeast(display_long)|uniprotkb:HMG-CoA reductase degradation protein 1(gene name synonym)|uniprotkb:HRD1(gene name)|psi-mi:HRD1(display_short)|uniprotkb:DER3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HRD1(gene name synonym)|uniprotkb:YOL013C(locus name)	psi-mi:ubx2_yeast(display_long)|uniprotkb:SEL1(gene name synonym)|uniprotkb:YM9571.05(orf name)|uniprotkb:YML013W(locus name)|uniprotkb:UBX2(gene name)|psi-mi:UBX2(display_short)|uniprotkb:Secretion lowering protein 1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Carvalho et al. (2010)	pubmed:21074049|imex:IM-15200	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2946549|imex:IM-15200-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014630.1|sgd:S000005373|dip:DIP-8850N|mint:Q08109|ensemblfungi:YOL013C(gene)|ensemblfungi:YOL013C_mRNA(transcript)|go:"GO:0000838"(Hrd1p ubiquitin ligase ERAD-M complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR032832|rcsb pdb:5V6P|rcsb pdb:6VJY|rcsb pdb:6VJZ|rcsb pdb:6VK0|rcsb pdb:6VK1|reactome:R-SCE-5358346	refseq:NP_013699.1|sgd:S000004475|dip:DIP-5073N|mint:Q04228|ensemblfungi:YML013W(gene)|ensemblfungi:YML013W_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|interpro:IPR001012(UBX)	psi-mi:"MI:0469"(intact)	-	crc64:DA4DDD3D624C17B8	figure legend:Supp. Fig. 5C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/11/25	2014/10/16	rogid:3ZN9xobcUi6DPqnKgASUmdGL/3g559292	rogid:pHZ9MnjC5Y3aC5hV43Z4fmkqI8w559292	intact-crc:8C38E9F7BC981D7B|rigid:0KxjcSAElcrQT+niRbRT3RBqLvY	false	sufficient binding region:1-86,207-551|calmodulin binding peptide plus protein a tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08109	uniprotkb:Q03714	intact:EBI-37613|uniprotkb:D6W254|ensemblfungi:YOL013C	intact:EBI-27760|uniprotkb:D6VZE5|ensemblfungi:YML029W	psi-mi:hrd1_yeast(display_long)|uniprotkb:HMG-CoA reductase degradation protein 1(gene name synonym)|uniprotkb:HRD1(gene name)|psi-mi:HRD1(display_short)|uniprotkb:DER3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HRD1(gene name synonym)|uniprotkb:YOL013C(locus name)	psi-mi:usa1_yeast(display_long)|uniprotkb:USA1(gene name)|psi-mi:USA1(display_short)|uniprotkb:YML029W(locus name)	psi-mi:"MI:0676"(tandem affinity purification)	Carvalho et al. (2010)	pubmed:21074049|imex:IM-15200	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2946549|imex:IM-15200-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014630.1|sgd:S000005373|dip:DIP-8850N|mint:Q08109|ensemblfungi:YOL013C(gene)|ensemblfungi:YOL013C_mRNA(transcript)|go:"GO:0000838"(Hrd1p ubiquitin ligase ERAD-M complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR032832|rcsb pdb:5V6P|rcsb pdb:6VJY|rcsb pdb:6VJZ|rcsb pdb:6VK0|rcsb pdb:6VK1|reactome:R-SCE-5358346	refseq:NP_013683.1|sgd:S000004491|dip:DIP-6423N|mint:Q03714|ensemblfungi:YML029W(gene)|ensemblfungi:YML029W_mRNA(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|rcsb pdb:6VJZ|rcsb pdb:6VK0	psi-mi:"MI:0469"(intact)	-	crc64:9B93ECA6C5421FD6	figure legend:Supp. Fig. 5C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/11/25	2014/10/16	rogid:3ZN9xobcUi6DPqnKgASUmdGL/3g559292	rogid:k5/W6R8NnkOWchVSQSoXCbvaAZ8559292	intact-crc:8C38E9F7BC981D7B|rigid:0KxjcSAElcrQT+niRbRT3RBqLvY	false	sufficient binding region:1-86,207-551|calmodulin binding peptide plus protein a tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08109	uniprotkb:Q99220	intact:EBI-37613|uniprotkb:D6W254|ensemblfungi:YOL013C	intact:EBI-34938|uniprotkb:Q04313|uniprotkb:D6VS43|ensemblfungi:YDR057W	psi-mi:hrd1_yeast(display_long)|uniprotkb:HMG-CoA reductase degradation protein 1(gene name synonym)|uniprotkb:HRD1(gene name)|psi-mi:HRD1(display_short)|uniprotkb:DER3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HRD1(gene name synonym)|uniprotkb:YOL013C(locus name)	psi-mi:os9_yeast(display_long)|uniprotkb:YOS9(gene name)|psi-mi:YOS9(display_short)|uniprotkb:D4222(orf name)|uniprotkb:YDR057W(locus name)	psi-mi:"MI:0676"(tandem affinity purification)	Carvalho et al. (2010)	pubmed:21074049|imex:IM-15200	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2946549|imex:IM-15200-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014630.1|sgd:S000005373|dip:DIP-8850N|mint:Q08109|ensemblfungi:YOL013C(gene)|ensemblfungi:YOL013C_mRNA(transcript)|go:"GO:0000838"(Hrd1p ubiquitin ligase ERAD-M complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR032832|rcsb pdb:5V6P|rcsb pdb:6VJY|rcsb pdb:6VJZ|rcsb pdb:6VK0|rcsb pdb:6VK1|reactome:R-SCE-5358346	sgd:S000002464|interpro:IPR012913(Glucosidase II beta subunit-like)|refseq:NP_010342.3|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|mint:Q99220|interpro:IPR041039|ensemblfungi:YDR057W(gene)|ensemblfungi:YDR057W_mRNA(transcript)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0034099"(luminal surveillance complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0070492"(oligosaccharide binding)|go:"GO:0097466"(ubiquitin-dependent glycoprotein ERAD pathway)|rcsb pdb:2YMA|rcsb pdb:6VK3|reactome:R-SCE-5358346|interpro:IPR044865	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 5C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/11/25	2014/10/16	rogid:3ZN9xobcUi6DPqnKgASUmdGL/3g559292	rogid:XGjxSgW5NGOWgeqqhPnIYbXfJmc559292	intact-crc:8C38E9F7BC981D7B|rigid:0KxjcSAElcrQT+niRbRT3RBqLvY	false	sufficient binding region:1-86,207-551|calmodulin binding peptide plus protein a tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08109	uniprotkb:P25694	intact:EBI-37613|uniprotkb:D6W254|ensemblfungi:YOL013C	intact:EBI-4308|ensemblfungi:YDL126C|uniprotkb:D6VRM4	psi-mi:hrd1_yeast(display_long)|uniprotkb:HMG-CoA reductase degradation protein 1(gene name synonym)|uniprotkb:HRD1(gene name)|psi-mi:HRD1(display_short)|uniprotkb:DER3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HRD1(gene name synonym)|uniprotkb:YOL013C(locus name)	psi-mi:cdc48_yeast(display_long)|uniprotkb:CDC48(gene name)|psi-mi:CDC48(display_short)|uniprotkb:Cell division cycle protein 48(gene name synonym)|uniprotkb:Transitional endoplasmic reticulum ATPase homolog(gene name synonym)|uniprotkb:YDL126C(locus name)	psi-mi:"MI:0676"(tandem affinity purification)	Carvalho et al. (2010)	pubmed:21074049|imex:IM-15200	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2946549|imex:IM-15200-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014630.1|sgd:S000005373|dip:DIP-8850N|mint:Q08109|ensemblfungi:YOL013C(gene)|ensemblfungi:YOL013C_mRNA(transcript)|go:"GO:0000838"(Hrd1p ubiquitin ligase ERAD-M complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR032832|rcsb pdb:5V6P|rcsb pdb:6VJY|rcsb pdb:6VJZ|rcsb pdb:6VK0|rcsb pdb:6VK1|reactome:R-SCE-5358346	refseq:NP_010157.1|sgd:S000002284|ensemblfungi:YDL126C(gene)|ensemblfungi:YDL126C_mRNA(transcript)|go:"GO:0000837"(Doa10p ubiquitin ligase complex)|dip:DIP-2704N|mint:P25694|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006274"(DNA replication termination)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0016236"(macroautophagy)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030894"(replisome)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034517"(ribophagy)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0036266"(Cdc48p-Npl4p-Vms1p AAA ATPase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043332"(mating projection tip)|go:"GO:0043624"|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072671"(mitochondria-associated ubiquitin-dependent protein catabolic process)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0120174"(stress-induced homeostatically regulated protein degradation pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|go:"GO:1990171"(SCF complex disassembly in response to cadmium stress)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|rcsb pdb:6OA9|rcsb pdb:6OAA|rcsb pdb:6OAB|rcsb pdb:6OMB|rcsb pdb:6OPC|reactome:R-SCE-110320|reactome:R-SCE-3371511|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5689896|reactome:R-SCE-6798695|reactome:R-SCE-8876725	psi-mi:"MI:0469"(intact)	-	crc64:02ADDB9A227614D8	figure legend:Supp. Fig. 5C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/11/25	2014/10/16	rogid:3ZN9xobcUi6DPqnKgASUmdGL/3g559292	rogid:qM/04kWcyjkQ3QCa3WklyvhNigE559292	intact-crc:8C38E9F7BC981D7B|rigid:0KxjcSAElcrQT+niRbRT3RBqLvY	false	sufficient binding region:1-86,207-551|calmodulin binding peptide plus protein a tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q08109	uniprotkb:Q05787	intact:EBI-37613|uniprotkb:D6W254|ensemblfungi:YOL013C	intact:EBI-31647|uniprotkb:D6VYK8|ensemblfungi:YLR207W	psi-mi:hrd1_yeast(display_long)|uniprotkb:HMG-CoA reductase degradation protein 1(gene name synonym)|uniprotkb:HRD1(gene name)|psi-mi:HRD1(display_short)|uniprotkb:DER3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HRD1(gene name synonym)|uniprotkb:YOL013C(locus name)	psi-mi:hrd3_yeast(display_long)|uniprotkb:HMG-CoA reductase degradation protein 3(gene name synonym)|uniprotkb:HRD3(gene name)|psi-mi:HRD3(display_short)|uniprotkb:YLR207W(locus name)	psi-mi:"MI:0676"(tandem affinity purification)	Carvalho et al. (2010)	pubmed:21074049|imex:IM-15200	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2946549|imex:IM-15200-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014630.1|sgd:S000005373|dip:DIP-8850N|mint:Q08109|ensemblfungi:YOL013C(gene)|ensemblfungi:YOL013C_mRNA(transcript)|go:"GO:0000838"(Hrd1p ubiquitin ligase ERAD-M complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR032832|rcsb pdb:5V6P|rcsb pdb:6VJY|rcsb pdb:6VJZ|rcsb pdb:6VK0|rcsb pdb:6VK1|reactome:R-SCE-5358346	refseq:NP_013308.1|sgd:S000004197|dip:DIP-2843N|mint:Q05787|ensemblfungi:YLR207W(gene)|ensemblfungi:YLR207W_mRNA(transcript)|go:"GO:0000838"(Hrd1p ubiquitin ligase ERAD-M complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0034099"(luminal surveillance complex)|go:"GO:1905524"(negative regulation of protein autoubiquitination)|interpro:IPR006597(Sel1-like)|interpro:IPR011990(Tetratricopeptide-like helical)|rcsb pdb:5V7V|rcsb pdb:6VJY|rcsb pdb:6VJZ|rcsb pdb:6VK0|rcsb pdb:6VK1|rcsb pdb:6VK3|reactome:R-SCE-5358346	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 5C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/11/25	2014/10/16	rogid:3ZN9xobcUi6DPqnKgASUmdGL/3g559292	rogid:MCNT6LrWgeCYdL5VJmtrbEZR6j4559292	intact-crc:8C38E9F7BC981D7B|rigid:0KxjcSAElcrQT+niRbRT3RBqLvY	false	sufficient binding region:1-86,207-551|calmodulin binding peptide plus protein a tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)