#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99LD4	uniprotkb:Q8VBV7	intact:EBI-8313949|uniprotkb:Q8C2J7|intact:MINT-1869858|uniprotkb:B0QZT1	intact:EBI-8320755|uniprotkb:Q3TRS9|intact:MINT-4092211|uniprotkb:Q80XF4|uniprotkb:Q8R4D2|ensembl:ENSMUSP00000035884	psi-mi:csn1_mouse(display_long)|uniprotkb:Gps1(gene name)|psi-mi:Gps1(display_short)|uniprotkb:Cops1(gene name synonym)|uniprotkb:Csn1(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 1(gene name synonym)|uniprotkb:G protein pathway suppressor 1(gene name synonym)	psi-mi:csn8_mouse(display_long)|uniprotkb:Cops8(gene name)|psi-mi:Cops8(display_short)|uniprotkb:Csn8(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 8(gene name synonym)|uniprotkb:COP9 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yoshida et al. (2010)	pubmed:20974137|imex:IM-15660|mint:MINT-8046248|doi:10.1016/j.febslet.2010.10.039	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8482462|mint:MINT-8046253|imex:IM-15660-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR033008|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|reactome:R-MMU-5696394|reactome:R-MMU-6781823|reactome:R-MMU-8856825|reactome:R-MMU-8951664|reactome:R-MMU-9013422|interpro:IPR019585|interpro:IPR036390|mint:Q99LD4|interpro:IPR000717(Proteasome component region PCI)|mint:MINT-8046255(identity)	refseq:NP_598566.3|ensembl:ENSMUSG00000034432(gene)|ensembl:ENSMUST00000036153(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010387"(COP9 signalosome assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR033205|interpro:IPR033464|mint:Q8VBV7|reactome:R-MMU-5696394|reactome:R-MMU-6781823|reactome:R-MMU-8856825|reactome:R-MMU-8951664|mint:MINT-8046257(identity)	-	comment:mint|function:"Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein-and mitogen-activated protein kinase-mediated signal transduction"	comment:mint|function:"Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively"	figure legend:f1d|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2010/10/18	2014/10/16	rogid:sd18zpeaq9Xs/VDNTz0ATO5HkkU10090	rogid:ryWlA8ZuwkRZcupvmluMG5AXZyk10090	intact-crc:0BDD1194AD17BB93|rigid:HuVm6HGOlF+mh3zCdmcX+KqsQaY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99LD4	uniprotkb:Q8BV13	intact:EBI-8313949|uniprotkb:Q8C2J7|intact:MINT-1869858|uniprotkb:B0QZT1	intact:EBI-8419951|uniprotkb:O88547|intact:MINT-4092196|uniprotkb:Q3TGG7|uniprotkb:Q921G4|ensembl:ENSMUSP00000027446|ensembl:ENSMUSP00000113587	psi-mi:csn1_mouse(display_long)|uniprotkb:Gps1(gene name)|psi-mi:Gps1(display_short)|uniprotkb:Cops1(gene name synonym)|uniprotkb:Csn1(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 1(gene name synonym)|uniprotkb:G protein pathway suppressor 1(gene name synonym)	psi-mi:csn7b_mouse(display_long)|uniprotkb:Cops7b(gene name)|psi-mi:Cops7b(display_short)|uniprotkb:Csn7b(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 7b(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yoshida et al. (2010)	pubmed:20974137|imex:IM-15660|mint:MINT-8046248|doi:10.1016/j.febslet.2010.10.039	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8482462|mint:MINT-8046253|imex:IM-15660-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR033008|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|reactome:R-MMU-5696394|reactome:R-MMU-6781823|reactome:R-MMU-8856825|reactome:R-MMU-8951664|reactome:R-MMU-9013422|interpro:IPR019585|interpro:IPR036390|mint:Q99LD4|interpro:IPR000717(Proteasome component region PCI)|mint:MINT-8046255(identity)	refseq:NP_766562.1|refseq:XP_006529686.1|refseq:XP_006529687.1|ensembl:ENSMUSG00000026240(gene)|ensembl:ENSMUST00000027446(transcript)|ensembl:ENSMUST00000121534(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010387"(COP9 signalosome assembly)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR027530|interpro:IPR041481|mint:Q8BV13|reactome:R-MMU-5696394|reactome:R-MMU-6781823|reactome:R-MMU-8856825|reactome:R-MMU-8951664|mint:MINT-8046259(identity)	-	comment:mint|function:"Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein-and mitogen-activated protein kinase-mediated signal transduction"	comment:mint|function:"Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively"	figure legend:f1d|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2010/10/18	2014/10/16	rogid:sd18zpeaq9Xs/VDNTz0ATO5HkkU10090	rogid:QIY7UMYgCbwmaeAzWwFtj0aoZic10090	intact-crc:0BDD1194AD17BB93|rigid:HuVm6HGOlF+mh3zCdmcX+KqsQaY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99LD4	uniprotkb:O35864	intact:EBI-8313949|uniprotkb:Q8C2J7|intact:MINT-1869858|uniprotkb:B0QZT1	intact:EBI-8391842|intact:MINT-2620150|uniprotkb:Q3UA70|uniprotkb:Q8C1S1|ensembl:ENSMUSP00000027050	psi-mi:csn1_mouse(display_long)|uniprotkb:Gps1(gene name)|psi-mi:Gps1(display_short)|uniprotkb:Cops1(gene name synonym)|uniprotkb:Csn1(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 1(gene name synonym)|uniprotkb:G protein pathway suppressor 1(gene name synonym)	psi-mi:csn5_mouse(display_long)|uniprotkb:Cops5(gene name)|psi-mi:Cops5(display_short)|uniprotkb:Csn5(gene name synonym)|uniprotkb:Jab1(gene name synonym)|uniprotkb:Kic2(gene name synonym)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:Kip1 C-terminus-interacting protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yoshida et al. (2010)	pubmed:20974137|imex:IM-15660|mint:MINT-8046248|doi:10.1016/j.febslet.2010.10.039	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8482462|mint:MINT-8046253|imex:IM-15660-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR033008|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|reactome:R-MMU-5696394|reactome:R-MMU-6781823|reactome:R-MMU-8856825|reactome:R-MMU-8951664|reactome:R-MMU-9013422|interpro:IPR019585|interpro:IPR036390|mint:Q99LD4|interpro:IPR000717(Proteasome component region PCI)|mint:MINT-8046255(identity)	refseq:NP_001264030.1|refseq:NP_038743.1|interpro:IPR037740|interpro:IPR040961|mint:O35864|reactome:R-MMU-5696394|reactome:R-MMU-6781823|reactome:R-MMU-8856825|reactome:R-MMU-8951664|ensembl:ENSMUSG00000025917(gene)|ensembl:ENSMUST00000027050(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|mint:MINT-8046256(identity)	-	comment:mint|function:"Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein-and mitogen-activated protein kinase-mediated signal transduction"	comment:mint|function:"Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts direclty with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex"	figure legend:f1d|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2010/10/18	2014/10/16	rogid:sd18zpeaq9Xs/VDNTz0ATO5HkkU10090	rogid:HPe2K3K31lH58+gFxzw+4/sBEUc10090	intact-crc:0BDD1194AD17BB93|rigid:HuVm6HGOlF+mh3zCdmcX+KqsQaY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99LD4	uniprotkb:O88545	intact:EBI-8313949|uniprotkb:Q8C2J7|intact:MINT-1869858|uniprotkb:B0QZT1	intact:EBI-8347582|intact:MINT-4092182|ensembl:ENSMUSP00000019638	psi-mi:csn1_mouse(display_long)|uniprotkb:Gps1(gene name)|psi-mi:Gps1(display_short)|uniprotkb:Cops1(gene name synonym)|uniprotkb:Csn1(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 1(gene name synonym)|uniprotkb:G protein pathway suppressor 1(gene name synonym)	psi-mi:csn6_mouse(display_long)|uniprotkb:Cops6(gene name)|psi-mi:Cops6(display_short)|uniprotkb:Csn6(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yoshida et al. (2010)	pubmed:20974137|imex:IM-15660|mint:MINT-8046248|doi:10.1016/j.febslet.2010.10.039	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8482462|mint:MINT-8046253|imex:IM-15660-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR033008|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|reactome:R-MMU-5696394|reactome:R-MMU-6781823|reactome:R-MMU-8856825|reactome:R-MMU-8951664|reactome:R-MMU-9013422|interpro:IPR019585|interpro:IPR036390|mint:Q99LD4|interpro:IPR000717(Proteasome component region PCI)|mint:MINT-8046255(identity)	refseq:NP_036132.1|ensembl:ENSMUSG00000019494(gene)|ensembl:ENSMUST00000019638(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033859|interpro:IPR037518|mint:O88545|reactome:R-MMU-5696394|reactome:R-MMU-6781823|reactome:R-MMU-8856825|reactome:R-MMU-8951664|mint:MINT-8046260(identity)	-	comment:mint|function:"Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein-and mitogen-activated protein kinase-mediated signal transduction"	comment:mint|function:"Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity"	figure legend:f1d|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2010/10/18	2014/10/16	rogid:sd18zpeaq9Xs/VDNTz0ATO5HkkU10090	rogid:M0sshMhYdlCBDvTmgpfcY5VoyDY10090	intact-crc:0BDD1194AD17BB93|rigid:HuVm6HGOlF+mh3zCdmcX+KqsQaY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99LD4	uniprotkb:O88543	intact:EBI-8313949|uniprotkb:Q8C2J7|intact:MINT-1869858|uniprotkb:B0QZT1	intact:EBI-772767|ensembl:ENSMUSP00000019517	psi-mi:csn1_mouse(display_long)|uniprotkb:Gps1(gene name)|psi-mi:Gps1(display_short)|uniprotkb:Cops1(gene name synonym)|uniprotkb:Csn1(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 1(gene name synonym)|uniprotkb:G protein pathway suppressor 1(gene name synonym)	psi-mi:csn3_mouse(display_long)|uniprotkb:JAB1-containing signalosome subunit 3(gene name synonym)|uniprotkb:Cops3(gene name)|psi-mi:Cops3(display_short)|uniprotkb:Csn3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yoshida et al. (2010)	pubmed:20974137|imex:IM-15660|mint:MINT-8046248|doi:10.1016/j.febslet.2010.10.039	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8482462|mint:MINT-8046253|imex:IM-15660-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR033008|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|reactome:R-MMU-5696394|reactome:R-MMU-6781823|reactome:R-MMU-8856825|reactome:R-MMU-8951664|reactome:R-MMU-9013422|interpro:IPR019585|interpro:IPR036390|mint:Q99LD4|interpro:IPR000717(Proteasome component region PCI)|mint:MINT-8046255(identity)	refseq:NP_036121.1|ensembl:ENSMUSG00000019373(gene)|ensembl:ENSMUST00000019517(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008180"(COP9 signalosome)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR036390|interpro:IPR037753|mint:O88543|reactome:R-MMU-5696394|reactome:R-MMU-6781823|reactome:R-MMU-8856825|reactome:R-MMU-8951664|mint:MINT-8046258(identity)	-	comment:mint|function:"Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein-and mitogen-activated protein kinase-mediated signal transduction"	-	figure legend:f1d|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2010/10/18	2014/10/16	rogid:sd18zpeaq9Xs/VDNTz0ATO5HkkU10090	rogid:a4nGsHhkBjqvMQZeDC7GBvIKz6k10090	intact-crc:0BDD1194AD17BB93|rigid:HuVm6HGOlF+mh3zCdmcX+KqsQaY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)