#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P79762	uniprotkb:P79762	intact:EBI-2942236|ensembl:ENSGALP00000002368|uniprotkb:Q4VU57|uniprotkb:Q4VU62|uniprotkb:Q4VU63|uniprotkb:Q4VU66|uniprotkb:Q9PWF8|uniprotkb:Q4VU46|uniprotkb:Q4VU49|uniprotkb:Q4VU50|uniprotkb:Q4VU53|uniprotkb:Q4VU54	intact:EBI-2942236|ensembl:ENSGALP00000002368|uniprotkb:Q4VU57|uniprotkb:Q4VU62|uniprotkb:Q4VU63|uniprotkb:Q4VU66|uniprotkb:Q9PWF8|uniprotkb:Q4VU46|uniprotkb:Q4VU49|uniprotkb:Q4VU50|uniprotkb:Q4VU53|uniprotkb:Q4VU54	psi-mi:zp3_chick(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:Zona pellucida C protein(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)	psi-mi:zp3_chick(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:Zona pellucida C protein(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Han et al. (2010)	pubmed:20970175|imex:IM-15179	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2942246|imex:IM-15179-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSGALG00000001559(gene)|ensembl:ENSGALT00000002370(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032570"(response to progesterone)|go:"GO:0033574"(response to testosterone)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0045177"(apical part of cell)|go:"GO:2000344"(positive regulation of acrosome reaction)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|rcsb pdb:3NK3|rcsb pdb:3NK4|refseq:NP_989720.3	ensembl:ENSGALG00000001559(gene)|ensembl:ENSGALT00000002370(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032570"(response to progesterone)|go:"GO:0033574"(response to testosterone)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0045177"(apical part of cell)|go:"GO:2000344"(positive regulation of acrosome reaction)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|rcsb pdb:3NK3|rcsb pdb:3NK4|refseq:NP_989720.3	go:"GO:0042803"(protein homodimerization activity)	-	-	comment:"Radius of gyration (Rg) of 32.02 A."|figure legend:Supp. Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2010/11/09	2014/10/16	rogid:yREMaTYk38GslofkhI7HHMfAW1s9031	rogid:yREMaTYk38GslofkhI7HHMfAW1s9031	intact-crc:945D28DE0E6E05C9|rigid:ekLMNA7GAeqKYNHoHI+lDe2enmI	false	his tag:c-c|sufficient binding region:1-382|mutation:361-362,159-159,359-359	his tag:c-c|sufficient binding region:1-382|mutation:361-362,159-159,359-359	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P79762	uniprotkb:P79762	intact:EBI-2942236|ensembl:ENSGALP00000002368|uniprotkb:Q4VU57|uniprotkb:Q4VU62|uniprotkb:Q4VU63|uniprotkb:Q4VU66|uniprotkb:Q9PWF8|uniprotkb:Q4VU46|uniprotkb:Q4VU49|uniprotkb:Q4VU50|uniprotkb:Q4VU53|uniprotkb:Q4VU54	intact:EBI-2942236|ensembl:ENSGALP00000002368|uniprotkb:Q4VU57|uniprotkb:Q4VU62|uniprotkb:Q4VU63|uniprotkb:Q4VU66|uniprotkb:Q9PWF8|uniprotkb:Q4VU46|uniprotkb:Q4VU49|uniprotkb:Q4VU50|uniprotkb:Q4VU53|uniprotkb:Q4VU54	psi-mi:zp3_chick(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:Zona pellucida C protein(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)	psi-mi:zp3_chick(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:Zona pellucida C protein(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Han et al. (2010)	pubmed:20970175|imex:IM-15179	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2942281|imex:IM-15179-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSGALG00000001559(gene)|ensembl:ENSGALT00000002370(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032570"(response to progesterone)|go:"GO:0033574"(response to testosterone)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0045177"(apical part of cell)|go:"GO:2000344"(positive regulation of acrosome reaction)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|rcsb pdb:3NK3|rcsb pdb:3NK4|refseq:NP_989720.3	ensembl:ENSGALG00000001559(gene)|ensembl:ENSGALT00000002370(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032570"(response to progesterone)|go:"GO:0033574"(response to testosterone)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0045177"(apical part of cell)|go:"GO:2000344"(positive regulation of acrosome reaction)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|rcsb pdb:3NK3|rcsb pdb:3NK4|refseq:NP_989720.3	go:"GO:0042803"(protein homodimerization activity)	-	-	figure legend:Supp. Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/11/09	2014/10/16	rogid:yREMaTYk38GslofkhI7HHMfAW1s9031	rogid:yREMaTYk38GslofkhI7HHMfAW1s9031	intact-crc:0AECB0107473C4C4|rigid:ekLMNA7GAeqKYNHoHI+lDe2enmI	false	sufficient binding region:1-382|mutation:361-362,159-159,359-359|his tag:c-c	sufficient binding region:1-382|mutation:361-362,159-159,359-359|his tag:c-c	2	0	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:P79762	uniprotkb:P79762	intact:EBI-2942236|ensembl:ENSGALP00000002368|uniprotkb:Q4VU57|uniprotkb:Q4VU62|uniprotkb:Q4VU63|uniprotkb:Q4VU66|uniprotkb:Q9PWF8|uniprotkb:Q4VU46|uniprotkb:Q4VU49|uniprotkb:Q4VU50|uniprotkb:Q4VU53|uniprotkb:Q4VU54	intact:EBI-2942236|ensembl:ENSGALP00000002368|uniprotkb:Q4VU57|uniprotkb:Q4VU62|uniprotkb:Q4VU63|uniprotkb:Q4VU66|uniprotkb:Q9PWF8|uniprotkb:Q4VU46|uniprotkb:Q4VU49|uniprotkb:Q4VU50|uniprotkb:Q4VU53|uniprotkb:Q4VU54	psi-mi:zp3_chick(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:Zona pellucida C protein(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)	psi-mi:zp3_chick(display_long)|uniprotkb:ZP3(gene name)|psi-mi:ZP3(display_short)|uniprotkb:ZPC(gene name synonym)|uniprotkb:Sperm receptor(gene name synonym)|uniprotkb:Zona pellucida C protein(gene name synonym)|uniprotkb:Zona pellucida glycoprotein 3(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Han et al. (2010)	pubmed:20970175|imex:IM-15179	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2942312|imex:IM-15179-3|wwpdb:3NK3|wwpdb:3NK4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSGALG00000001559(gene)|ensembl:ENSGALT00000002370(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032570"(response to progesterone)|go:"GO:0033574"(response to testosterone)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0045177"(apical part of cell)|go:"GO:2000344"(positive regulation of acrosome reaction)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|rcsb pdb:3NK3|rcsb pdb:3NK4|refseq:NP_989720.3	ensembl:ENSGALG00000001559(gene)|ensembl:ENSGALT00000002370(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032190"(acrosin binding)|go:"GO:0032570"(response to progesterone)|go:"GO:0033574"(response to testosterone)|go:"GO:0035803"(egg coat formation)|go:"GO:0035804"(structural constituent of egg coat)|go:"GO:0042802"(identical protein binding)|go:"GO:0045177"(apical part of cell)|go:"GO:2000344"(positive regulation of acrosome reaction)|interpro:IPR001507(Endoglin/CD105 antigen)|interpro:IPR017977|interpro:IPR040196|interpro:IPR042235|rcsb pdb:3NK3|rcsb pdb:3NK4|refseq:NP_989720.3	go:"GO:0042803"(protein homodimerization activity)	-	-	figure legend:Supp. Fig. 5, Supp. Table 1|3d-resolution:2.0-2.6A|3d-r-factors:"R working 21.9%, R free 24.9% (3NK3)"|3d-structure:Two molecules of ZP3 embrace each other in antiparallel orientation to form a flat, Yin-Yang-shaped homodimer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/11/09	2014/10/16	rogid:yREMaTYk38GslofkhI7HHMfAW1s9031	rogid:yREMaTYk38GslofkhI7HHMfAW1s9031	intact-crc:6D140587BE3190B8|rigid:ekLMNA7GAeqKYNHoHI+lDe2enmI	false	sufficient binding region:53-347(IPR001507)|his tag:c-c	sufficient binding region:53-347(IPR001507)|his tag:c-c	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)