#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q03164	uniprotkb:P45481	intact:EBI-591370|ensembl:ENSP00000374157|uniprotkb:Q13743|uniprotkb:Q13744|uniprotkb:Q14845|uniprotkb:Q16364|uniprotkb:Q6UBD1|uniprotkb:Q9UMA3|intact:EBI-2614650|uniprotkb:Q59FF2|uniprotkb:Q9UD94|uniprotkb:E9PQG7|uniprotkb:Q9HBJ3	intact:EBI-296306|uniprotkb:E9QPH4	psi-mi:kmt2a_human(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:cbp_mouse(display_long)|uniprotkb:Crebbp(gene name)|psi-mi:Crebbp(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Protein-lysine acetyltransferase CREBBP(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Arai et al. (2010)	pubmed:20969867|imex:IM-15850|mint:MINT-8044017|doi:10.1016/j.febslet.2010.10.024	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8475388|mint:MINT-8044564|imex:IM-15850-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:2000615"(regulation of histone H3-K9 acetylation)|interpro:IPR001214(SET)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|interpro:IPR036427|interpro:IPR037927|interpro:IPR041958|interpro:IPR042023|interpro:IPR042025|interpro:IPR044133|mint:Q03164|rcsb pdb:2AGH|rcsb pdb:2J2S|rcsb pdb:2JYI|rcsb pdb:2KKF|rcsb pdb:2KU7|rcsb pdb:2KYU|rcsb pdb:2LXS|rcsb pdb:2LXT|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2W5Y|ensembl:ENSG00000118058(gene)|ensembl:ENST00000389506(transcript)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071440"(regulation of histone H3-K14 acetylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|go:"GO:1905642"(negative regulation of DNA methylation)|refseq:NP_001184033.1|refseq:NP_005924.2|ensembl:ENSP00000374157|ensembl:ENST00000534358|ensembl:ENSP00000436786|ensembl:ENST00000649699|ensembl:ENSP00000496927|dip:DIP-29221N|rcsb pdb:2W5Z|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3LQH|rcsb pdb:3LQI|rcsb pdb:3LQJ|rcsb pdb:3P4F|rcsb pdb:3U85|rcsb pdb:3U88|rcsb pdb:4ESG|rcsb pdb:4GQ6|rcsb pdb:4NW3|rcsb pdb:5F5E|rcsb pdb:5F6L|rcsb pdb:5SVH|rcsb pdb:6EMQ|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U9K|rcsb pdb:6U9M|rcsb pdb:6U9N|rcsb pdb:6U9R|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|reactome:R-HSA-3214841|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9616222|mint:MINT-8044567(identity)	go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000785"(chromatin)|go:"GO:0000940"(outer kinetochore)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018076"(N-terminal peptidyl-lysine acetylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043426"(MRF binding)|rcsb pdb:1KBH|rcsb pdb:1KDX|rcsb pdb:1JJS|rcsb pdb:1L8C|rcsb pdb:1R8U|rcsb pdb:1SB0|rcsb pdb:1TOT|rcsb pdb:1U2N|rcsb pdb:2AGH|rcsb pdb:2C52|rcsb pdb:2KA4|rcsb pdb:2KA6|rcsb pdb:2KKJ|rcsb pdb:2L14|rcsb pdb:2LQH|rcsb pdb:2LQI|rcsb pdb:2LWW|rcsb pdb:4I9O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5U4K|rcsb pdb:5U7G|rcsb pdb:5W0I|rcsb pdb:6DMX|rcsb pdb:6DNQ|reactome:R-MMU-1234158|reactome:R-MMU-201722|reactome:R-MMU-2122947|reactome:R-MMU-3134973|reactome:R-MMU-3371568|reactome:R-MMU-350054|reactome:R-MMU-400206|reactome:R-MMU-5621575|reactome:R-MMU-8866907|reactome:R-MMU-8939246|reactome:R-MMU-8941856|reactome:R-MMU-9018519|reactome:R-MMU-918233|reactome:R-MMU-933541|reactome:R-MMU-9617629|reactome:R-MMU-9707564|go:"GO:0046332"(SMAD binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061733"(peptide-lysine-N-acetyltransferase activity)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1990258"(histone glutamine methylation)|interpro:IPR000197(Zinc finger, TAZ-type)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR001487(Bromodomain)|interpro:IPR003101(Coactivator CBP, KIX)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010303(Protein of unknown function DUF902, CREBbp)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013178(H3K56 histone acetylation protein, RTT109)|interpro:IPR014744(Nuclear receptor coactivator, CREB-bp-like, interlocking)|interpro:IPR018359|interpro:IPR031162|interpro:IPR035898|interpro:IPR036427|interpro:IPR036529|interpro:IPR037073|interpro:IPR038547|interpro:IPR043145|rcsb pdb:1F81|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|mint:P45481|dip:DIP-5974N|mint:MINT-8044566(identity)	-	-	-	comment:homomint|comment:domino|comment:mint|figure legend:f1d st1 sf1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.1x10^-6(molar)	2010/10/11	2014/10/16	rogid:r9J9pjnLZI7GCBSHYqnmzjv9WvM9606	rogid:sBMFm6ZE5MtCDEN3UiSiwTbvSqA10090	intact-crc:C21E2B252C1BB2B2|rigid:F0QLN7jFH8VAFEVcpQeXXD/6D9A	false	binding-associated region:2842-2869(MINT-8044577)	binding-associated region:?-?(MINT-8044572)|mutation disrupting interaction:628-628(MINT-8044652)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P45481	uniprotkb:Q03164	intact:EBI-296306|uniprotkb:E9QPH4	intact:EBI-591370|ensembl:ENSP00000374157|uniprotkb:Q13743|uniprotkb:Q13744|uniprotkb:Q14845|uniprotkb:Q16364|uniprotkb:Q6UBD1|uniprotkb:Q9UMA3|intact:EBI-2614650|uniprotkb:Q59FF2|uniprotkb:Q9UD94|uniprotkb:E9PQG7|uniprotkb:Q9HBJ3	psi-mi:cbp_mouse(display_long)|uniprotkb:Crebbp(gene name)|psi-mi:Crebbp(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Protein-lysine acetyltransferase CREBBP(gene name synonym)	psi-mi:kmt2a_human(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Arai et al. (2010)	pubmed:20969867|imex:IM-15850|mint:MINT-8044017|doi:10.1016/j.febslet.2010.10.024	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8475481|mint:MINT-8044598|imex:IM-15850-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000785"(chromatin)|go:"GO:0000940"(outer kinetochore)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018076"(N-terminal peptidyl-lysine acetylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043426"(MRF binding)|rcsb pdb:1KBH|rcsb pdb:1KDX|rcsb pdb:1JJS|rcsb pdb:1L8C|rcsb pdb:1R8U|rcsb pdb:1SB0|rcsb pdb:1TOT|rcsb pdb:1U2N|rcsb pdb:2AGH|rcsb pdb:2C52|rcsb pdb:2KA4|rcsb pdb:2KA6|rcsb pdb:2KKJ|rcsb pdb:2L14|rcsb pdb:2LQH|rcsb pdb:2LQI|rcsb pdb:2LWW|rcsb pdb:4I9O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5U4K|rcsb pdb:5U7G|rcsb pdb:5W0I|rcsb pdb:6DMX|rcsb pdb:6DNQ|reactome:R-MMU-1234158|reactome:R-MMU-201722|reactome:R-MMU-2122947|reactome:R-MMU-3134973|reactome:R-MMU-3371568|reactome:R-MMU-350054|reactome:R-MMU-400206|reactome:R-MMU-5621575|reactome:R-MMU-8866907|reactome:R-MMU-8939246|reactome:R-MMU-8941856|reactome:R-MMU-9018519|reactome:R-MMU-918233|reactome:R-MMU-933541|reactome:R-MMU-9617629|reactome:R-MMU-9707564|go:"GO:0046332"(SMAD binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061733"(peptide-lysine-N-acetyltransferase activity)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1990258"(histone glutamine methylation)|interpro:IPR000197(Zinc finger, TAZ-type)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR001487(Bromodomain)|interpro:IPR003101(Coactivator CBP, KIX)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010303(Protein of unknown function DUF902, CREBbp)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013178(H3K56 histone acetylation protein, RTT109)|interpro:IPR014744(Nuclear receptor coactivator, CREB-bp-like, interlocking)|interpro:IPR018359|interpro:IPR031162|interpro:IPR035898|interpro:IPR036427|interpro:IPR036529|interpro:IPR037073|interpro:IPR038547|interpro:IPR043145|rcsb pdb:1F81|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|mint:P45481|dip:DIP-5974N|mint:MINT-8044601(identity)	go:"GO:2000615"(regulation of histone H3-K9 acetylation)|interpro:IPR001214(SET)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|interpro:IPR036427|interpro:IPR037927|interpro:IPR041958|interpro:IPR042023|interpro:IPR042025|interpro:IPR044133|mint:Q03164|rcsb pdb:2AGH|rcsb pdb:2J2S|rcsb pdb:2JYI|rcsb pdb:2KKF|rcsb pdb:2KU7|rcsb pdb:2KYU|rcsb pdb:2LXS|rcsb pdb:2LXT|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2W5Y|ensembl:ENSG00000118058(gene)|ensembl:ENST00000389506(transcript)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071440"(regulation of histone H3-K14 acetylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|go:"GO:1905642"(negative regulation of DNA methylation)|refseq:NP_001184033.1|refseq:NP_005924.2|ensembl:ENSP00000374157|ensembl:ENST00000534358|ensembl:ENSP00000436786|ensembl:ENST00000649699|ensembl:ENSP00000496927|dip:DIP-29221N|rcsb pdb:2W5Z|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3LQH|rcsb pdb:3LQI|rcsb pdb:3LQJ|rcsb pdb:3P4F|rcsb pdb:3U85|rcsb pdb:3U88|rcsb pdb:4ESG|rcsb pdb:4GQ6|rcsb pdb:4NW3|rcsb pdb:5F5E|rcsb pdb:5F6L|rcsb pdb:5SVH|rcsb pdb:6EMQ|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U9K|rcsb pdb:6U9M|rcsb pdb:6U9N|rcsb pdb:6U9R|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|reactome:R-HSA-3214841|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9616222|mint:MINT-8044608(identity)	-	-	-	comment:homomint|comment:domino|comment:mint|figure legend:f1d st1 sf1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:10.4x10^-6(molar)	2010/10/11	2014/10/16	rogid:sBMFm6ZE5MtCDEN3UiSiwTbvSqA10090	rogid:r9J9pjnLZI7GCBSHYqnmzjv9WvM9606	intact-crc:D81280D1DD990CEF|rigid:F0QLN7jFH8VAFEVcpQeXXD/6D9A	false	binding-associated region:?-?(MINT-8044604)|mutation decreasing interaction:668-668(MINT-8044602)	binding-associated region:2842-2869(MINT-8044609)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P45481	uniprotkb:Q03164	intact:EBI-296306|uniprotkb:E9QPH4	intact:EBI-591370|ensembl:ENSP00000374157|uniprotkb:Q13743|uniprotkb:Q13744|uniprotkb:Q14845|uniprotkb:Q16364|uniprotkb:Q6UBD1|uniprotkb:Q9UMA3|intact:EBI-2614650|uniprotkb:Q59FF2|uniprotkb:Q9UD94|uniprotkb:E9PQG7|uniprotkb:Q9HBJ3	psi-mi:cbp_mouse(display_long)|uniprotkb:Crebbp(gene name)|psi-mi:Crebbp(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Protein-lysine acetyltransferase CREBBP(gene name synonym)	psi-mi:kmt2a_human(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Arai et al. (2010)	pubmed:20969867|imex:IM-15850|mint:MINT-8044017|doi:10.1016/j.febslet.2010.10.024	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8475453|mint:MINT-8044580|imex:IM-15850-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000785"(chromatin)|go:"GO:0000940"(outer kinetochore)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018076"(N-terminal peptidyl-lysine acetylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043426"(MRF binding)|rcsb pdb:1KBH|rcsb pdb:1KDX|rcsb pdb:1JJS|rcsb pdb:1L8C|rcsb pdb:1R8U|rcsb pdb:1SB0|rcsb pdb:1TOT|rcsb pdb:1U2N|rcsb pdb:2AGH|rcsb pdb:2C52|rcsb pdb:2KA4|rcsb pdb:2KA6|rcsb pdb:2KKJ|rcsb pdb:2L14|rcsb pdb:2LQH|rcsb pdb:2LQI|rcsb pdb:2LWW|rcsb pdb:4I9O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5U4K|rcsb pdb:5U7G|rcsb pdb:5W0I|rcsb pdb:6DMX|rcsb pdb:6DNQ|reactome:R-MMU-1234158|reactome:R-MMU-201722|reactome:R-MMU-2122947|reactome:R-MMU-3134973|reactome:R-MMU-3371568|reactome:R-MMU-350054|reactome:R-MMU-400206|reactome:R-MMU-5621575|reactome:R-MMU-8866907|reactome:R-MMU-8939246|reactome:R-MMU-8941856|reactome:R-MMU-9018519|reactome:R-MMU-918233|reactome:R-MMU-933541|reactome:R-MMU-9617629|reactome:R-MMU-9707564|go:"GO:0046332"(SMAD binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061733"(peptide-lysine-N-acetyltransferase activity)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1990258"(histone glutamine methylation)|interpro:IPR000197(Zinc finger, TAZ-type)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR001487(Bromodomain)|interpro:IPR003101(Coactivator CBP, KIX)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010303(Protein of unknown function DUF902, CREBbp)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013178(H3K56 histone acetylation protein, RTT109)|interpro:IPR014744(Nuclear receptor coactivator, CREB-bp-like, interlocking)|interpro:IPR018359|interpro:IPR031162|interpro:IPR035898|interpro:IPR036427|interpro:IPR036529|interpro:IPR037073|interpro:IPR038547|interpro:IPR043145|rcsb pdb:1F81|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|mint:P45481|dip:DIP-5974N|mint:MINT-8044583(identity)	go:"GO:2000615"(regulation of histone H3-K9 acetylation)|interpro:IPR001214(SET)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|interpro:IPR036427|interpro:IPR037927|interpro:IPR041958|interpro:IPR042023|interpro:IPR042025|interpro:IPR044133|mint:Q03164|rcsb pdb:2AGH|rcsb pdb:2J2S|rcsb pdb:2JYI|rcsb pdb:2KKF|rcsb pdb:2KU7|rcsb pdb:2KYU|rcsb pdb:2LXS|rcsb pdb:2LXT|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2W5Y|ensembl:ENSG00000118058(gene)|ensembl:ENST00000389506(transcript)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071440"(regulation of histone H3-K14 acetylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|go:"GO:1905642"(negative regulation of DNA methylation)|refseq:NP_001184033.1|refseq:NP_005924.2|ensembl:ENSP00000374157|ensembl:ENST00000534358|ensembl:ENSP00000436786|ensembl:ENST00000649699|ensembl:ENSP00000496927|dip:DIP-29221N|rcsb pdb:2W5Z|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3LQH|rcsb pdb:3LQI|rcsb pdb:3LQJ|rcsb pdb:3P4F|rcsb pdb:3U85|rcsb pdb:3U88|rcsb pdb:4ESG|rcsb pdb:4GQ6|rcsb pdb:4NW3|rcsb pdb:5F5E|rcsb pdb:5F6L|rcsb pdb:5SVH|rcsb pdb:6EMQ|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U9K|rcsb pdb:6U9M|rcsb pdb:6U9N|rcsb pdb:6U9R|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|reactome:R-HSA-3214841|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9616222|mint:MINT-8044588(identity)	-	-	-	comment:homomint|comment:domino|comment:mint|figure legend:f1d st1 sf1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:5.9x10^-6(molar)	2010/10/11	2014/10/16	rogid:sBMFm6ZE5MtCDEN3UiSiwTbvSqA10090	rogid:r9J9pjnLZI7GCBSHYqnmzjv9WvM9606	intact-crc:590C077B88EC5861|rigid:F0QLN7jFH8VAFEVcpQeXXD/6D9A	false	mutation decreasing interaction:624-624(MINT-8044594)|binding-associated region:?-?(MINT-8044584)	binding-associated region:2842-2869(MINT-8044589)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q03164	uniprotkb:P45481	intact:EBI-591370|ensembl:ENSP00000374157|uniprotkb:Q13743|uniprotkb:Q13744|uniprotkb:Q14845|uniprotkb:Q16364|uniprotkb:Q6UBD1|uniprotkb:Q9UMA3|intact:EBI-2614650|uniprotkb:Q59FF2|uniprotkb:Q9UD94|uniprotkb:E9PQG7|uniprotkb:Q9HBJ3	intact:EBI-296306|uniprotkb:E9QPH4	psi-mi:kmt2a_human(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:cbp_mouse(display_long)|uniprotkb:Crebbp(gene name)|psi-mi:Crebbp(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Protein-lysine acetyltransferase CREBBP(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Arai et al. (2010)	pubmed:20969867|imex:IM-15850|mint:MINT-8044017|doi:10.1016/j.febslet.2010.10.024	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8475557|mint:MINT-8044634|imex:IM-15850-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:2000615"(regulation of histone H3-K9 acetylation)|interpro:IPR001214(SET)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|interpro:IPR036427|interpro:IPR037927|interpro:IPR041958|interpro:IPR042023|interpro:IPR042025|interpro:IPR044133|mint:Q03164|rcsb pdb:2AGH|rcsb pdb:2J2S|rcsb pdb:2JYI|rcsb pdb:2KKF|rcsb pdb:2KU7|rcsb pdb:2KYU|rcsb pdb:2LXS|rcsb pdb:2LXT|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2W5Y|ensembl:ENSG00000118058(gene)|ensembl:ENST00000389506(transcript)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071440"(regulation of histone H3-K14 acetylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|go:"GO:1905642"(negative regulation of DNA methylation)|refseq:NP_001184033.1|refseq:NP_005924.2|ensembl:ENSP00000374157|ensembl:ENST00000534358|ensembl:ENSP00000436786|ensembl:ENST00000649699|ensembl:ENSP00000496927|dip:DIP-29221N|rcsb pdb:2W5Z|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3LQH|rcsb pdb:3LQI|rcsb pdb:3LQJ|rcsb pdb:3P4F|rcsb pdb:3U85|rcsb pdb:3U88|rcsb pdb:4ESG|rcsb pdb:4GQ6|rcsb pdb:4NW3|rcsb pdb:5F5E|rcsb pdb:5F6L|rcsb pdb:5SVH|rcsb pdb:6EMQ|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U9K|rcsb pdb:6U9M|rcsb pdb:6U9N|rcsb pdb:6U9R|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|reactome:R-HSA-3214841|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9616222|mint:MINT-8044644(identity)	go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000785"(chromatin)|go:"GO:0000940"(outer kinetochore)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018076"(N-terminal peptidyl-lysine acetylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043426"(MRF binding)|rcsb pdb:1KBH|rcsb pdb:1KDX|rcsb pdb:1JJS|rcsb pdb:1L8C|rcsb pdb:1R8U|rcsb pdb:1SB0|rcsb pdb:1TOT|rcsb pdb:1U2N|rcsb pdb:2AGH|rcsb pdb:2C52|rcsb pdb:2KA4|rcsb pdb:2KA6|rcsb pdb:2KKJ|rcsb pdb:2L14|rcsb pdb:2LQH|rcsb pdb:2LQI|rcsb pdb:2LWW|rcsb pdb:4I9O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5U4K|rcsb pdb:5U7G|rcsb pdb:5W0I|rcsb pdb:6DMX|rcsb pdb:6DNQ|reactome:R-MMU-1234158|reactome:R-MMU-201722|reactome:R-MMU-2122947|reactome:R-MMU-3134973|reactome:R-MMU-3371568|reactome:R-MMU-350054|reactome:R-MMU-400206|reactome:R-MMU-5621575|reactome:R-MMU-8866907|reactome:R-MMU-8939246|reactome:R-MMU-8941856|reactome:R-MMU-9018519|reactome:R-MMU-918233|reactome:R-MMU-933541|reactome:R-MMU-9617629|reactome:R-MMU-9707564|go:"GO:0046332"(SMAD binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061733"(peptide-lysine-N-acetyltransferase activity)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1990258"(histone glutamine methylation)|interpro:IPR000197(Zinc finger, TAZ-type)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR001487(Bromodomain)|interpro:IPR003101(Coactivator CBP, KIX)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010303(Protein of unknown function DUF902, CREBbp)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013178(H3K56 histone acetylation protein, RTT109)|interpro:IPR014744(Nuclear receptor coactivator, CREB-bp-like, interlocking)|interpro:IPR018359|interpro:IPR031162|interpro:IPR035898|interpro:IPR036427|interpro:IPR036529|interpro:IPR037073|interpro:IPR038547|interpro:IPR043145|rcsb pdb:1F81|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|mint:P45481|dip:DIP-5974N|mint:MINT-8044637(identity)	-	-	-	comment:homomint|comment:domino|comment:mint|figure legend:f1d st1 sf1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:51.0x10^-6(molar)	2010/10/11	2014/10/16	rogid:r9J9pjnLZI7GCBSHYqnmzjv9WvM9606	rogid:sBMFm6ZE5MtCDEN3UiSiwTbvSqA10090	intact-crc:42EA50CB8127CDDE|rigid:F0QLN7jFH8VAFEVcpQeXXD/6D9A	false	binding-associated region:2842-2869(MINT-8044645)	binding-associated region:?-?(MINT-8044640)|mutation decreasing interaction:664-664(MINT-8044638)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P45481	uniprotkb:Q03164	intact:EBI-296306|uniprotkb:E9QPH4	intact:EBI-591370|ensembl:ENSP00000374157|uniprotkb:Q13743|uniprotkb:Q13744|uniprotkb:Q14845|uniprotkb:Q16364|uniprotkb:Q6UBD1|uniprotkb:Q9UMA3|intact:EBI-2614650|uniprotkb:Q59FF2|uniprotkb:Q9UD94|uniprotkb:E9PQG7|uniprotkb:Q9HBJ3	psi-mi:cbp_mouse(display_long)|uniprotkb:Crebbp(gene name)|psi-mi:Crebbp(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Protein-lysine acetyltransferase CREBBP(gene name synonym)	psi-mi:kmt2a_human(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Arai et al. (2010)	pubmed:20969867|imex:IM-15850|mint:MINT-8044017|doi:10.1016/j.febslet.2010.10.024	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8475509|mint:MINT-8044616|imex:IM-15850-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000785"(chromatin)|go:"GO:0000940"(outer kinetochore)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018076"(N-terminal peptidyl-lysine acetylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043426"(MRF binding)|rcsb pdb:1KBH|rcsb pdb:1KDX|rcsb pdb:1JJS|rcsb pdb:1L8C|rcsb pdb:1R8U|rcsb pdb:1SB0|rcsb pdb:1TOT|rcsb pdb:1U2N|rcsb pdb:2AGH|rcsb pdb:2C52|rcsb pdb:2KA4|rcsb pdb:2KA6|rcsb pdb:2KKJ|rcsb pdb:2L14|rcsb pdb:2LQH|rcsb pdb:2LQI|rcsb pdb:2LWW|rcsb pdb:4I9O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5U4K|rcsb pdb:5U7G|rcsb pdb:5W0I|rcsb pdb:6DMX|rcsb pdb:6DNQ|reactome:R-MMU-1234158|reactome:R-MMU-201722|reactome:R-MMU-2122947|reactome:R-MMU-3134973|reactome:R-MMU-3371568|reactome:R-MMU-350054|reactome:R-MMU-400206|reactome:R-MMU-5621575|reactome:R-MMU-8866907|reactome:R-MMU-8939246|reactome:R-MMU-8941856|reactome:R-MMU-9018519|reactome:R-MMU-918233|reactome:R-MMU-933541|reactome:R-MMU-9617629|reactome:R-MMU-9707564|go:"GO:0046332"(SMAD binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061733"(peptide-lysine-N-acetyltransferase activity)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1990258"(histone glutamine methylation)|interpro:IPR000197(Zinc finger, TAZ-type)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR001487(Bromodomain)|interpro:IPR003101(Coactivator CBP, KIX)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010303(Protein of unknown function DUF902, CREBbp)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013178(H3K56 histone acetylation protein, RTT109)|interpro:IPR014744(Nuclear receptor coactivator, CREB-bp-like, interlocking)|interpro:IPR018359|interpro:IPR031162|interpro:IPR035898|interpro:IPR036427|interpro:IPR036529|interpro:IPR037073|interpro:IPR038547|interpro:IPR043145|rcsb pdb:1F81|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|mint:P45481|dip:DIP-5974N|mint:MINT-8044619(identity)	go:"GO:2000615"(regulation of histone H3-K9 acetylation)|interpro:IPR001214(SET)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|interpro:IPR036427|interpro:IPR037927|interpro:IPR041958|interpro:IPR042023|interpro:IPR042025|interpro:IPR044133|mint:Q03164|rcsb pdb:2AGH|rcsb pdb:2J2S|rcsb pdb:2JYI|rcsb pdb:2KKF|rcsb pdb:2KU7|rcsb pdb:2KYU|rcsb pdb:2LXS|rcsb pdb:2LXT|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2W5Y|ensembl:ENSG00000118058(gene)|ensembl:ENST00000389506(transcript)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071440"(regulation of histone H3-K14 acetylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|go:"GO:1905642"(negative regulation of DNA methylation)|refseq:NP_001184033.1|refseq:NP_005924.2|ensembl:ENSP00000374157|ensembl:ENST00000534358|ensembl:ENSP00000436786|ensembl:ENST00000649699|ensembl:ENSP00000496927|dip:DIP-29221N|rcsb pdb:2W5Z|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3LQH|rcsb pdb:3LQI|rcsb pdb:3LQJ|rcsb pdb:3P4F|rcsb pdb:3U85|rcsb pdb:3U88|rcsb pdb:4ESG|rcsb pdb:4GQ6|rcsb pdb:4NW3|rcsb pdb:5F5E|rcsb pdb:5F6L|rcsb pdb:5SVH|rcsb pdb:6EMQ|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U9K|rcsb pdb:6U9M|rcsb pdb:6U9N|rcsb pdb:6U9R|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|reactome:R-HSA-3214841|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9616222|mint:MINT-8044626(identity)	-	-	-	comment:homomint|comment:domino|comment:mint|figure legend:f1d st1 sf1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:31.0x10^-6(molar)	2010/10/11	2014/10/16	rogid:sBMFm6ZE5MtCDEN3UiSiwTbvSqA10090	rogid:r9J9pjnLZI7GCBSHYqnmzjv9WvM9606	intact-crc:3437CE9C33EE6DDA|rigid:F0QLN7jFH8VAFEVcpQeXXD/6D9A	false	binding-associated region:?-?(MINT-8044620)|mutation decreasing interaction:631-631(MINT-8044623)	binding-associated region:2842-2869(MINT-8044627)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q03164	uniprotkb:P45481	intact:EBI-591370|ensembl:ENSP00000374157|uniprotkb:Q13743|uniprotkb:Q13744|uniprotkb:Q14845|uniprotkb:Q16364|uniprotkb:Q6UBD1|uniprotkb:Q9UMA3|intact:EBI-2614650|uniprotkb:Q59FF2|uniprotkb:Q9UD94|uniprotkb:E9PQG7|uniprotkb:Q9HBJ3	intact:EBI-296306|uniprotkb:E9QPH4	psi-mi:kmt2a_human(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:cbp_mouse(display_long)|uniprotkb:Crebbp(gene name)|psi-mi:Crebbp(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Protein-lysine acetyltransferase CREBBP(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Arai et al. (2010)	pubmed:20969867|imex:IM-15850|mint:MINT-8044017|doi:10.1016/j.febslet.2010.10.024	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8475602|mint:MINT-8044656|imex:IM-15850-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:2000615"(regulation of histone H3-K9 acetylation)|interpro:IPR001214(SET)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|interpro:IPR036427|interpro:IPR037927|interpro:IPR041958|interpro:IPR042023|interpro:IPR042025|interpro:IPR044133|mint:Q03164|rcsb pdb:2AGH|rcsb pdb:2J2S|rcsb pdb:2JYI|rcsb pdb:2KKF|rcsb pdb:2KU7|rcsb pdb:2KYU|rcsb pdb:2LXS|rcsb pdb:2LXT|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2W5Y|ensembl:ENSG00000118058(gene)|ensembl:ENST00000389506(transcript)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071440"(regulation of histone H3-K14 acetylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|go:"GO:1905642"(negative regulation of DNA methylation)|refseq:NP_001184033.1|refseq:NP_005924.2|ensembl:ENSP00000374157|ensembl:ENST00000534358|ensembl:ENSP00000436786|ensembl:ENST00000649699|ensembl:ENSP00000496927|dip:DIP-29221N|rcsb pdb:2W5Z|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3LQH|rcsb pdb:3LQI|rcsb pdb:3LQJ|rcsb pdb:3P4F|rcsb pdb:3U85|rcsb pdb:3U88|rcsb pdb:4ESG|rcsb pdb:4GQ6|rcsb pdb:4NW3|rcsb pdb:5F5E|rcsb pdb:5F6L|rcsb pdb:5SVH|rcsb pdb:6EMQ|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U9K|rcsb pdb:6U9M|rcsb pdb:6U9N|rcsb pdb:6U9R|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|reactome:R-HSA-3214841|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9616222|mint:MINT-8044666(identity)	go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000785"(chromatin)|go:"GO:0000940"(outer kinetochore)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018076"(N-terminal peptidyl-lysine acetylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043426"(MRF binding)|rcsb pdb:1KBH|rcsb pdb:1KDX|rcsb pdb:1JJS|rcsb pdb:1L8C|rcsb pdb:1R8U|rcsb pdb:1SB0|rcsb pdb:1TOT|rcsb pdb:1U2N|rcsb pdb:2AGH|rcsb pdb:2C52|rcsb pdb:2KA4|rcsb pdb:2KA6|rcsb pdb:2KKJ|rcsb pdb:2L14|rcsb pdb:2LQH|rcsb pdb:2LQI|rcsb pdb:2LWW|rcsb pdb:4I9O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5U4K|rcsb pdb:5U7G|rcsb pdb:5W0I|rcsb pdb:6DMX|rcsb pdb:6DNQ|reactome:R-MMU-1234158|reactome:R-MMU-201722|reactome:R-MMU-2122947|reactome:R-MMU-3134973|reactome:R-MMU-3371568|reactome:R-MMU-350054|reactome:R-MMU-400206|reactome:R-MMU-5621575|reactome:R-MMU-8866907|reactome:R-MMU-8939246|reactome:R-MMU-8941856|reactome:R-MMU-9018519|reactome:R-MMU-918233|reactome:R-MMU-933541|reactome:R-MMU-9617629|reactome:R-MMU-9707564|go:"GO:0046332"(SMAD binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061733"(peptide-lysine-N-acetyltransferase activity)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1990258"(histone glutamine methylation)|interpro:IPR000197(Zinc finger, TAZ-type)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR001487(Bromodomain)|interpro:IPR003101(Coactivator CBP, KIX)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010303(Protein of unknown function DUF902, CREBbp)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013178(H3K56 histone acetylation protein, RTT109)|interpro:IPR014744(Nuclear receptor coactivator, CREB-bp-like, interlocking)|interpro:IPR018359|interpro:IPR031162|interpro:IPR035898|interpro:IPR036427|interpro:IPR036529|interpro:IPR037073|interpro:IPR038547|interpro:IPR043145|rcsb pdb:1F81|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|mint:P45481|dip:DIP-5974N|mint:MINT-8044659(identity)	-	-	-	comment:homomint|comment:domino|comment:mint|figure legend:f1d st1 sf1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:80.0x10^-6(molar)	2010/10/11	2014/10/16	rogid:r9J9pjnLZI7GCBSHYqnmzjv9WvM9606	rogid:sBMFm6ZE5MtCDEN3UiSiwTbvSqA10090	intact-crc:AB7AD142A0241749|rigid:F0QLN7jFH8VAFEVcpQeXXD/6D9A	false	binding-associated region:2842-2869(MINT-8044667)	mutation decreasing interaction:612-612(MINT-8044663)|binding-associated region:?-?(MINT-8044660)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P45481	uniprotkb:Q03164	intact:EBI-296306|uniprotkb:E9QPH4	intact:EBI-591370|ensembl:ENSP00000374157|uniprotkb:Q13743|uniprotkb:Q13744|uniprotkb:Q14845|uniprotkb:Q16364|uniprotkb:Q6UBD1|uniprotkb:Q9UMA3|intact:EBI-2614650|uniprotkb:Q59FF2|uniprotkb:Q9UD94|uniprotkb:E9PQG7|uniprotkb:Q9HBJ3	psi-mi:cbp_mouse(display_long)|uniprotkb:Crebbp(gene name)|psi-mi:Crebbp(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Protein-lysine acetyltransferase CREBBP(gene name synonym)	psi-mi:kmt2a_human(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Arai et al. (2010)	pubmed:20969867|imex:IM-15850|mint:MINT-8044017|doi:10.1016/j.febslet.2010.10.024	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8475639|mint:MINT-8044696|imex:IM-15850-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000785"(chromatin)|go:"GO:0000940"(outer kinetochore)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018076"(N-terminal peptidyl-lysine acetylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043426"(MRF binding)|rcsb pdb:1KBH|rcsb pdb:1KDX|rcsb pdb:1JJS|rcsb pdb:1L8C|rcsb pdb:1R8U|rcsb pdb:1SB0|rcsb pdb:1TOT|rcsb pdb:1U2N|rcsb pdb:2AGH|rcsb pdb:2C52|rcsb pdb:2KA4|rcsb pdb:2KA6|rcsb pdb:2KKJ|rcsb pdb:2L14|rcsb pdb:2LQH|rcsb pdb:2LQI|rcsb pdb:2LWW|rcsb pdb:4I9O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5U4K|rcsb pdb:5U7G|rcsb pdb:5W0I|rcsb pdb:6DMX|rcsb pdb:6DNQ|reactome:R-MMU-1234158|reactome:R-MMU-201722|reactome:R-MMU-2122947|reactome:R-MMU-3134973|reactome:R-MMU-3371568|reactome:R-MMU-350054|reactome:R-MMU-400206|reactome:R-MMU-5621575|reactome:R-MMU-8866907|reactome:R-MMU-8939246|reactome:R-MMU-8941856|reactome:R-MMU-9018519|reactome:R-MMU-918233|reactome:R-MMU-933541|reactome:R-MMU-9617629|reactome:R-MMU-9707564|go:"GO:0046332"(SMAD binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061733"(peptide-lysine-N-acetyltransferase activity)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1990258"(histone glutamine methylation)|interpro:IPR000197(Zinc finger, TAZ-type)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR001487(Bromodomain)|interpro:IPR003101(Coactivator CBP, KIX)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010303(Protein of unknown function DUF902, CREBbp)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013178(H3K56 histone acetylation protein, RTT109)|interpro:IPR014744(Nuclear receptor coactivator, CREB-bp-like, interlocking)|interpro:IPR018359|interpro:IPR031162|interpro:IPR035898|interpro:IPR036427|interpro:IPR036529|interpro:IPR037073|interpro:IPR038547|interpro:IPR043145|rcsb pdb:1F81|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|mint:P45481|dip:DIP-5974N|mint:MINT-8044698(identity)	go:"GO:2000615"(regulation of histone H3-K9 acetylation)|interpro:IPR001214(SET)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|interpro:IPR036427|interpro:IPR037927|interpro:IPR041958|interpro:IPR042023|interpro:IPR042025|interpro:IPR044133|mint:Q03164|rcsb pdb:2AGH|rcsb pdb:2J2S|rcsb pdb:2JYI|rcsb pdb:2KKF|rcsb pdb:2KU7|rcsb pdb:2KYU|rcsb pdb:2LXS|rcsb pdb:2LXT|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2W5Y|ensembl:ENSG00000118058(gene)|ensembl:ENST00000389506(transcript)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071440"(regulation of histone H3-K14 acetylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|go:"GO:1905642"(negative regulation of DNA methylation)|refseq:NP_001184033.1|refseq:NP_005924.2|ensembl:ENSP00000374157|ensembl:ENST00000534358|ensembl:ENSP00000436786|ensembl:ENST00000649699|ensembl:ENSP00000496927|dip:DIP-29221N|rcsb pdb:2W5Z|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3LQH|rcsb pdb:3LQI|rcsb pdb:3LQJ|rcsb pdb:3P4F|rcsb pdb:3U85|rcsb pdb:3U88|rcsb pdb:4ESG|rcsb pdb:4GQ6|rcsb pdb:4NW3|rcsb pdb:5F5E|rcsb pdb:5F6L|rcsb pdb:5SVH|rcsb pdb:6EMQ|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U9K|rcsb pdb:6U9M|rcsb pdb:6U9N|rcsb pdb:6U9R|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|reactome:R-HSA-3214841|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9616222|mint:MINT-8044699(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f2 sf2  sf3 sf4 sf5 sf6 sf7 sf8 sf9|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:220.0x10^-6(molar)	2010/10/11	2014/10/16	rogid:sBMFm6ZE5MtCDEN3UiSiwTbvSqA10090	rogid:r9J9pjnLZI7GCBSHYqnmzjv9WvM9606	intact-crc:AB1E0456EF3EBAED|rigid:F0QLN7jFH8VAFEVcpQeXXD/6D9A	false	binding-associated region:?-?(MINT-8044703)|mutation decreasing interaction:628-628(MINT-8044719)	binding-associated region:2842-2869(MINT-8044724)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)