#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P30944	uniprotkb:Q6GQ04	intact:EBI-2945280|uniprotkb:Q91709	intact:EBI-995003	psi-mi:cadh1_xenla(display_long)|uniprotkb:cdh1(gene name)|psi-mi:cdh1(display_short)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:xTCAD-1(gene name synonym)	psi-mi:q6gq04_xenla(display_long)|uniprotkb:cdc27.S(gene name)|psi-mi:cdc27.S(display_short)|uniprotkb:MGC80529(gene name synonym)|uniprotkb:cdc27(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zeng et al. (2010)	pubmed:20951947|imex:IM-15161	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2943573|imex:IM-15161-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0016021"(integral component of membrane)|interpro:IPR002126(Cadherin)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR014868(Cadherin prodomain like)|refseq:NP_001165703.1|interpro:IPR030049|interpro:IPR027397|interpro:IPR039808	interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001085568.1|dip:DIP-61882N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1E.|antagonist:TAME - a small molecule inhibitor of the APC|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2010/11/09	2014/10/16	rogid:Nhqw/v8ATeqtrAk36GLqfdhGqQ08355	rogid:4kDiMS+d9DpEZyPbzDsa/pzmFB48355	intact-crc:B7F37E00D32A8AA7|rigid:hKvLqoAK2uTzOn5ssPH1YGzDqg4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:62167"	uniprotkb:Q6GQ04	intact:EBI-2943634	intact:EBI-995003	psi-mi:3h-tame(display_short)|psi-mi:"CHEBI:62167"(display_long)	psi-mi:q6gq04_xenla(display_long)|uniprotkb:cdc27.S(gene name)|psi-mi:cdc27.S(display_short)|uniprotkb:MGC80529(gene name synonym)|uniprotkb:cdc27(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zeng et al. (2010)	pubmed:20951947|imex:IM-15161	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2943810|imex:IM-15161-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001085568.1|dip:DIP-61882N	-	comment:tosyl -L -arginine methyl ester	-	figure legend:Fig 2A, 2B, S2A.|comment:Binding of 3H-TAME correlated with the amount of immunoprecipitated Cdc27. Unlabeled TAME competes with 3H-TAME.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2010/11/09	2014/10/16	-	rogid:4kDiMS+d9DpEZyPbzDsa/pzmFB48355	intact-crc:7722E5BCEC9FA7A8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:62167"	uniprotkb:P30260	intact:EBI-2943634	intact:EBI-994813|uniprotkb:Q16349|uniprotkb:Q96F35|ensembl:ENSP00000066544|uniprotkb:G3V1C4|intact:EBI-10972530	psi-mi:3h-tame(display_short)|psi-mi:"CHEBI:62167"(display_long)	psi-mi:cdc27_human(display_long)|uniprotkb:CDC27(gene name)|psi-mi:CDC27(display_short)|uniprotkb:D0S1430E(gene name synonym)|uniprotkb:D17S978E(gene name synonym)|uniprotkb:CDC27 homolog(gene name synonym)|uniprotkb:H-NUC(gene name synonym)|uniprotkb:ANAPC3(gene name synonym)|uniprotkb:Anaphase-promoting complex subunit 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zeng et al. (2010)	pubmed:20951947|imex:IM-15161	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2943829|imex:IM-15161-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000004897(gene)|ensembl:ENST00000066544(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0072686"(mitotic spindle)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|rcsb pdb:3T1N|go:"GO:0005680"(anaphase-promoting complex)|rcsb pdb:4RG6|rcsb pdb:4RG7|rcsb pdb:4RG9|rcsb pdb:4UI9|rcsb pdb:5A31|rcsb pdb:5G04|rcsb pdb:5G05|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5L9T|rcsb pdb:5L9U|rcsb pdb:5LCW|rcsb pdb:6Q6G|rcsb pdb:6Q6H|rcsb pdb:6TLJ|rcsb pdb:6TM5|rcsb pdb:6TNT|reactome:R-HSA-141430|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168|refseq:NP_001107563.1|refseq:NP_001247.3|dip:DIP-36422N	-	comment:tosyl -L -arginine methyl ester	-	figure legend:Fig 2C.|comment:TAME binds to human APC.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2010/11/09	2015/08/14	-	rogid:YOrJCRal5ZfO7kP2b8FPon0Yytw9606	intact-crc:647ABA0E89D0887F	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-2943906	uniprotkb:Q6GQ04	-	intact:EBI-995003	psi-mi:c_term_peptide(display_short)|psi-mi:EBI-2943906(display_long)	psi-mi:q6gq04_xenla(display_long)|uniprotkb:cdc27.S(gene name)|psi-mi:cdc27.S(display_short)|uniprotkb:MGC80529(gene name synonym)|uniprotkb:cdc27(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zeng et al. (2010)	pubmed:20951947|imex:IM-15161	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2943889|imex:IM-15161-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001085568.1|dip:DIP-61882N	psi-mi:"MI:0469"(intact)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Fig 2E.|caution:"Blasting the stated sequence of the  Cdh1 C-terminal peptide shows it does not correspond to the C terminal sequence for Xenopus Laevis Cdh1, however, it does correspond to  the C terminus of Chicken Cdh1 and the C terminus of Xenopus Fizzy-related protein (fzr1)."|comment:The peptide lacking the C-terminal isoleucine and arginine residues binds only weakly to cdc27.|antagonist:TAME|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2010/11/09	2014/10/16	rogid:pNDl1wAfDUnVFOjOri+vg+Bc3Js-2	rogid:4kDiMS+d9DpEZyPbzDsa/pzmFB48355	intact-crc:3C78E7F38865020F|rigid:sFTfszctOwBfzko3Xq6v8cmo8dc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6DFD4	uniprotkb:Q6GQ04	intact:EBI-2943560	intact:EBI-995003	psi-mi:q6dfd4_xenla(display_long)|uniprotkb:cdc20.L(gene name)|psi-mi:cdc20.L(display_short)|uniprotkb:LOC398044(gene name synonym)|uniprotkb:cdc20(gene name synonym)	psi-mi:q6gq04_xenla(display_long)|uniprotkb:cdc27.S(gene name)|psi-mi:cdc27.S(display_short)|uniprotkb:MGC80529(gene name synonym)|uniprotkb:cdc27(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zeng et al. (2010)	pubmed:20951947|imex:IM-15161	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2943949|imex:IM-15161-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|refseq:NP_001081776.1|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322	interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001085568.1|dip:DIP-61882N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 2F.|comment:TAME does not inhibit the interaction between the C-box and the APC.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2010/11/09	2014/10/16	rogid:kWfjPAA7emJYiGomxf7HMBqFA+s8355	rogid:4kDiMS+d9DpEZyPbzDsa/pzmFB48355	intact-crc:61FF21B3FCAA977E|rigid:fgEvtdFeN3OCBepTmVNqhPN5oEM	false	glutathione s tranferase tag:?-?|sufficient binding region:1-159|binding-associated region:86-90	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
intact:EBI-2943906	intact:EBI-2944724	-	-	psi-mi:c_term_peptide(display_short)|psi-mi:EBI-2943906(display_long)	psi-mi:apc1_xenla(display_short)|psi-mi:EBI-2944724(display_long)	psi-mi:"MI:0030"(cross-linking study)	Zeng et al. (2010)	pubmed:20951947|imex:IM-15161	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2944020|imex:IM-15161-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	-	psi-mi:"MI:0469"(intact)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:no gene model available in xenbase or any other database, let alone any protein.  However, for X. tropicalis a gene model  does exist.	figure legend:Fig 2G, S2B, S2C.|caution:"Blasting the stated sequence of the  Cdh1 C-terminal peptide shows it does not correspond to the C terminal sequence for Xenopus Laevis Cdh1, however, it does correspond to  the C terminus of Chicken Cdh1 and the C terminus of Xenopus Fizzy-related protein (fzr1)."|antagonist:TAME|comment:Four proteins known to exist in an APC subcomplex, namely, Cdc27, Cdc16, Cdc23, and Apc7, were crosslinked in an IR-dependent manner that could be competed by excess unlabeled IR peptide.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2010/11/09	2014/10/16	rogid:pNDl1wAfDUnVFOjOri+vg+Bc3Js-2	-	intact-crc:1946325A1E16920C	false	binding-associated region:20-21|biotin tag:1-1	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
intact:EBI-2943906	uniprotkb:Q6NU36	-	intact:EBI-2944299	psi-mi:c_term_peptide(display_short)|psi-mi:EBI-2943906(display_long)	psi-mi:q6nu36_xenla(display_long)|uniprotkb:anapc4.L(gene name)|psi-mi:anapc4.L(display_short)|uniprotkb:Cyclosome subunit 4(gene name synonym)|uniprotkb:MGC81278(gene name synonym)|uniprotkb:anapc4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Zeng et al. (2010)	pubmed:20951947|imex:IM-15161	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2944020|imex:IM-15161-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0007049"(cell cycle)|go:"GO:0030071"(regulation of mitotic metaphase/anaphase transition)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR017169(Anaphase-promoting complex, subunit 4)|interpro:IPR015943(WD40/YVTN repeat-like)|refseq:NP_001084578.1|rcsb pdb:5BPT|interpro:IPR024789|interpro:IPR024790|interpro:IPR024977|interpro:IPR036322	psi-mi:"MI:0469"(intact)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Fig 2G, S2B, S2C.|caution:"Blasting the stated sequence of the  Cdh1 C-terminal peptide shows it does not correspond to the C terminal sequence for Xenopus Laevis Cdh1, however, it does correspond to  the C terminus of Chicken Cdh1 and the C terminus of Xenopus Fizzy-related protein (fzr1)."|antagonist:TAME|comment:Four proteins known to exist in an APC subcomplex, namely, Cdc27, Cdc16, Cdc23, and Apc7, were crosslinked in an IR-dependent manner that could be competed by excess unlabeled IR peptide.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2010/11/09	2014/10/16	rogid:pNDl1wAfDUnVFOjOri+vg+Bc3Js-2	rogid:PcBOVboKMDiZTB21Krlz8IE2fwk8355	intact-crc:1946325A1E16920C	false	binding-associated region:20-21|biotin tag:1-1	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
intact:EBI-2943906	uniprotkb:Q0IH16	-	intact:EBI-2944308	psi-mi:c_term_peptide(display_short)|psi-mi:EBI-2943906(display_long)	psi-mi:q0ih16_xenla(display_long)|uniprotkb:anapc5.L(gene name)|psi-mi:anapc5.L(display_short)|uniprotkb:anapc5(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Zeng et al. (2010)	pubmed:20951947|imex:IM-15161	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2944020|imex:IM-15161-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0007049"(cell cycle)|go:"GO:0051301"(cell division)|refseq:NP_001090413.1|interpro:IPR026000|rcsb pdb:5BPZ|interpro:IPR016024(Armadillo-type fold)|interpro:IPR037679	psi-mi:"MI:0469"(intact)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Fig 2G, S2B, S2C.|caution:"Blasting the stated sequence of the  Cdh1 C-terminal peptide shows it does not correspond to the C terminal sequence for Xenopus Laevis Cdh1, however, it does correspond to  the C terminus of Chicken Cdh1 and the C terminus of Xenopus Fizzy-related protein (fzr1)."|antagonist:TAME|comment:Four proteins known to exist in an APC subcomplex, namely, Cdc27, Cdc16, Cdc23, and Apc7, were crosslinked in an IR-dependent manner that could be competed by excess unlabeled IR peptide.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2010/11/09	2014/10/16	rogid:pNDl1wAfDUnVFOjOri+vg+Bc3Js-2	rogid:Sy/qqyKtq1/8zm6zc3tgZPoUqYU8355	intact-crc:1946325A1E16920C	false	binding-associated region:20-21|biotin tag:1-1	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
intact:EBI-2943906	uniprotkb:C6ZIW0	-	intact:EBI-2944289	psi-mi:c_term_peptide(display_short)|psi-mi:EBI-2943906(display_long)	psi-mi:c6ziw0_xenla(display_long)	psi-mi:"MI:0030"(cross-linking study)	Zeng et al. (2010)	pubmed:20951947|imex:IM-15161	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2944020|imex:IM-15161-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	interpro:IPR044554	psi-mi:"MI:0469"(intact)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Fig 2G, S2B, S2C.|caution:"Blasting the stated sequence of the  Cdh1 C-terminal peptide shows it does not correspond to the C terminal sequence for Xenopus Laevis Cdh1, however, it does correspond to  the C terminus of Chicken Cdh1 and the C terminus of Xenopus Fizzy-related protein (fzr1)."|antagonist:TAME|comment:Four proteins known to exist in an APC subcomplex, namely, Cdc27, Cdc16, Cdc23, and Apc7, were crosslinked in an IR-dependent manner that could be competed by excess unlabeled IR peptide.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2010/11/09	2014/10/16	rogid:pNDl1wAfDUnVFOjOri+vg+Bc3Js-2	rogid:9hUOVkOf5338bVTijRnGe30duzc8355	intact-crc:1946325A1E16920C	false	binding-associated region:20-21|biotin tag:1-1	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
intact:EBI-2943906	uniprotkb:Q6DDX5	-	intact:EBI-2944068	psi-mi:c_term_peptide(display_short)|psi-mi:EBI-2943906(display_long)	psi-mi:q6ddx5_xenla(display_long)|uniprotkb:anapc7.L(gene name)|psi-mi:anapc7.L(display_short)|uniprotkb:anapc7(gene name synonym)|uniprotkb:anapc7-prov(gene name synonym)|uniprotkb:XELAEV_18007839mg(orf name)	psi-mi:"MI:0030"(cross-linking study)	Zeng et al. (2010)	pubmed:20951947|imex:IM-15161	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2944020|imex:IM-15161-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001086739.1	psi-mi:"MI:0469"(intact)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Fig 2G, S2B, S2C.|caution:"Blasting the stated sequence of the  Cdh1 C-terminal peptide shows it does not correspond to the C terminal sequence for Xenopus Laevis Cdh1, however, it does correspond to  the C terminus of Chicken Cdh1 and the C terminus of Xenopus Fizzy-related protein (fzr1)."|antagonist:TAME|comment:Four proteins known to exist in an APC subcomplex, namely, Cdc27, Cdc16, Cdc23, and Apc7, were crosslinked in an IR-dependent manner that could be competed by excess unlabeled IR peptide.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2010/11/09	2014/10/16	rogid:pNDl1wAfDUnVFOjOri+vg+Bc3Js-2	rogid:LGp1Q+y7InTdYPdPISy+kfBdXFQ8355	intact-crc:1946325A1E16920C	false	binding-associated region:20-21|biotin tag:1-1	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
intact:EBI-2943906	uniprotkb:Q6DFI7	-	intact:EBI-2944043	psi-mi:c_term_peptide(display_short)|psi-mi:EBI-2943906(display_long)	psi-mi:q6dfi7_xenla(display_long)|uniprotkb:cdc16.L(gene name)|psi-mi:cdc16.L(display_short)|uniprotkb:cdc16(gene name synonym)|uniprotkb:cdc16-prov(gene name synonym)|uniprotkb:XELAEV_18012976mg(orf name)	psi-mi:"MI:0030"(cross-linking study)	Zeng et al. (2010)	pubmed:20951947|imex:IM-15161	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2944020|imex:IM-15161-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001087093.1|dip:DIP-48552N	psi-mi:"MI:0469"(intact)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Fig 2G, S2B, S2C.|caution:"Blasting the stated sequence of the  Cdh1 C-terminal peptide shows it does not correspond to the C terminal sequence for Xenopus Laevis Cdh1, however, it does correspond to  the C terminus of Chicken Cdh1 and the C terminus of Xenopus Fizzy-related protein (fzr1)."|antagonist:TAME|comment:Four proteins known to exist in an APC subcomplex, namely, Cdc27, Cdc16, Cdc23, and Apc7, were crosslinked in an IR-dependent manner that could be competed by excess unlabeled IR peptide.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2010/11/09	2014/10/16	rogid:pNDl1wAfDUnVFOjOri+vg+Bc3Js-2	rogid:i2LJTWv7IUtsUnFOTO9ZHTwaLe48355	intact-crc:1946325A1E16920C	false	binding-associated region:20-21|biotin tag:1-1	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
intact:EBI-2943906	uniprotkb:Q7T0N9	-	intact:EBI-2944054	psi-mi:c_term_peptide(display_short)|psi-mi:EBI-2943906(display_long)	psi-mi:q7t0n9_xenla(display_long)|uniprotkb:cdc23.L(gene name)|psi-mi:cdc23.L(display_short)|uniprotkb:cdc23(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Zeng et al. (2010)	pubmed:20951947|imex:IM-15161	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2944020|imex:IM-15161-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0007049"(cell cycle)|go:"GO:0030071"(regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|interpro:IPR007192(Cdc23)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001079890.1	psi-mi:"MI:0469"(intact)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Fig 2G, S2B, S2C.|caution:"Blasting the stated sequence of the  Cdh1 C-terminal peptide shows it does not correspond to the C terminal sequence for Xenopus Laevis Cdh1, however, it does correspond to  the C terminus of Chicken Cdh1 and the C terminus of Xenopus Fizzy-related protein (fzr1)."|antagonist:TAME|comment:Four proteins known to exist in an APC subcomplex, namely, Cdc27, Cdc16, Cdc23, and Apc7, were crosslinked in an IR-dependent manner that could be competed by excess unlabeled IR peptide.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2010/11/09	2014/10/16	rogid:pNDl1wAfDUnVFOjOri+vg+Bc3Js-2	rogid:RFmfdaYEkR7WuhImo3IqAT2OQFw8355	intact-crc:1946325A1E16920C	false	binding-associated region:20-21|biotin tag:1-1	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q12834	uniprotkb:Q6GQ04	intact:EBI-367462|uniprotkb:Q5JUY4|uniprotkb:Q9BW56|uniprotkb:Q9UQI9|uniprotkb:B2R6Z6|uniprotkb:D3DPJ1|ensembl:ENSP00000308450|ensembl:ENSP00000361540	intact:EBI-995003	psi-mi:cdc20_human(display_long)|uniprotkb:CDC20(gene name)|psi-mi:CDC20(display_short)|uniprotkb:p55CDC(gene name synonym)	psi-mi:q6gq04_xenla(display_long)|uniprotkb:cdc27.S(gene name)|psi-mi:cdc27.S(display_short)|uniprotkb:MGC80529(gene name synonym)|uniprotkb:cdc27(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zeng et al. (2010)	pubmed:20951947|imex:IM-15161	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2944092|imex:IM-15161-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6Q6H|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174048|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176417|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-5689880|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-983168|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051301"(cell division)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q12834|rcsb pdb:4GGA|rcsb pdb:4GGC|rcsb pdb:4GGD|rcsb pdb:4N14|rcsb pdb:5G04|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6Q6G|refseq:NP_001246.2|ensembl:ENSG00000117399(gene)|ensembl:ENST00000310955(transcript)|ensembl:ENST00000372462(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-29655N	interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001085568.1|dip:DIP-61882N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 3.|antagonist:"TAME, C box containing N-terminal fragment of Cdc20 (aa's 1-159)."|comment:In the presence of the C-box-containing N-terminal fragment of Cdc20, the addition of TAME or deletion of the IR-tail was sufficient to completely suppress Cdc20 association with cdc27.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2010/11/09	2014/10/16	rogid:15j9Heovw6LpbClp5kT9Wz6a88A9606	rogid:4kDiMS+d9DpEZyPbzDsa/pzmFB48355	intact-crc:E1BA4749E9F6198B|rigid:QwjyJc/QHY9+Lbq+JwL/swOv0FE	false	binding-associated region:498-499	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P30260	uniprotkb:P12830	intact:EBI-994813|uniprotkb:Q16349|uniprotkb:Q96F35|ensembl:ENSP00000066544|uniprotkb:G3V1C4|intact:EBI-10972530	intact:EBI-727477|uniprotkb:Q13799|uniprotkb:Q14216|uniprotkb:Q15855|uniprotkb:Q16194|uniprotkb:Q4PJ14|uniprotkb:A8K1U7|intact:EBI-28986920|ensembl:ENSP00000261769|uniprotkb:Q9UII8	psi-mi:cdc27_human(display_long)|uniprotkb:CDC27(gene name)|psi-mi:CDC27(display_short)|uniprotkb:D0S1430E(gene name synonym)|uniprotkb:D17S978E(gene name synonym)|uniprotkb:CDC27 homolog(gene name synonym)|uniprotkb:H-NUC(gene name synonym)|uniprotkb:ANAPC3(gene name synonym)|uniprotkb:Anaphase-promoting complex subunit 3(gene name synonym)	psi-mi:cadh1_human(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:CAM 120/80(gene name synonym)|uniprotkb:CDH1(gene name)|psi-mi:CDH1(display_short)|uniprotkb:CDHE(gene name synonym)|uniprotkb:UVO(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zeng et al. (2010)	pubmed:20951947|imex:IM-15161	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2944128|imex:IM-15161-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000004897(gene)|ensembl:ENST00000066544(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0072686"(mitotic spindle)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|rcsb pdb:3T1N|go:"GO:0005680"(anaphase-promoting complex)|rcsb pdb:4RG6|rcsb pdb:4RG7|rcsb pdb:4RG9|rcsb pdb:4UI9|rcsb pdb:5A31|rcsb pdb:5G04|rcsb pdb:5G05|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5L9T|rcsb pdb:5L9U|rcsb pdb:5LCW|rcsb pdb:6Q6G|rcsb pdb:6Q6H|rcsb pdb:6TLJ|rcsb pdb:6TM5|rcsb pdb:6TNT|reactome:R-HSA-141430|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168|refseq:NP_001107563.1|refseq:NP_001247.3|dip:DIP-36422N	go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|ensembl:ENSG00000039068(gene)|refseq:NP_004351.1|ensembl:ENST00000261769(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|refseq:NP_001304113.1|refseq:NP_001304114.1|refseq:NP_001304115.1|ensembl:ENSP00000261769|ensembl:ENST00000422392|ensembl:ENSP00000414946|go:"GO:0016600"(flotillin complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|mint:P12830|rcsb pdb:1O6S|rcsb pdb:2O72|rcsb pdb:2OMT|rcsb pdb:2OMU|rcsb pdb:2OMV|rcsb pdb:2OMX|rcsb pdb:2OMY|rcsb pdb:2OMZ|rcsb pdb:3FF7|rcsb pdb:3FF8|rcsb pdb:3L6X|rcsb pdb:3L6Y|rcsb pdb:6VEL|reactome:R-HSA-1474228|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-351906|reactome:R-HSA-418990|reactome:R-HSA-5626467|reactome:R-HSA-8876493|rcsb pdb:4ZT1|rcsb pdb:4ZTE|rcsb pdb:6CXY|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|dip:DIP-477N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 4C.|antagonist:pro-TAME; a cell permeable derivative of TAME.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2010/11/09	2015/08/14	rogid:YOrJCRal5ZfO7kP2b8FPon0Yytw9606	rogid:WI/yBLas6W5mlgbyOErqeeUFNA49606	intact-crc:1A098014E900D0F0|rigid:D8wl55Tg2e9Nlchxq4Y9IVMt/1s	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6GQ04	intact:EBI-2944724	intact:EBI-995003	-	psi-mi:q6gq04_xenla(display_long)|uniprotkb:cdc27.S(gene name)|psi-mi:cdc27.S(display_short)|uniprotkb:MGC80529(gene name synonym)|uniprotkb:cdc27(gene name synonym)	psi-mi:apc1_xenla(display_short)|psi-mi:EBI-2944724(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zeng et al. (2010)	pubmed:20951947|imex:IM-15161	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2944221|imex:IM-15161-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001085568.1|dip:DIP-61882N	-	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:no gene model available in xenbase or any other database, let alone any protein.  However, for X. tropicalis a gene model  does exist.	figure legend:Fig S1E.|caution:"The participant EBI-2944289(C6ZIW0) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2010/11/09	2014/10/16	rogid:4kDiMS+d9DpEZyPbzDsa/pzmFB48355	-	intact-crc:B203A7574D135739	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6GQ04	uniprotkb:Q6NU36	intact:EBI-995003	intact:EBI-2944299	psi-mi:q6gq04_xenla(display_long)|uniprotkb:cdc27.S(gene name)|psi-mi:cdc27.S(display_short)|uniprotkb:MGC80529(gene name synonym)|uniprotkb:cdc27(gene name synonym)	psi-mi:q6nu36_xenla(display_long)|uniprotkb:anapc4.L(gene name)|psi-mi:anapc4.L(display_short)|uniprotkb:Cyclosome subunit 4(gene name synonym)|uniprotkb:MGC81278(gene name synonym)|uniprotkb:anapc4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zeng et al. (2010)	pubmed:20951947|imex:IM-15161	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2944221|imex:IM-15161-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001085568.1|dip:DIP-61882N	go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0007049"(cell cycle)|go:"GO:0030071"(regulation of mitotic metaphase/anaphase transition)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR017169(Anaphase-promoting complex, subunit 4)|interpro:IPR015943(WD40/YVTN repeat-like)|refseq:NP_001084578.1|rcsb pdb:5BPT|interpro:IPR024789|interpro:IPR024790|interpro:IPR024977|interpro:IPR036322	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1E.|caution:"The participant EBI-2944289(C6ZIW0) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2010/11/09	2014/10/16	rogid:4kDiMS+d9DpEZyPbzDsa/pzmFB48355	rogid:PcBOVboKMDiZTB21Krlz8IE2fwk8355	intact-crc:B203A7574D135739	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6GQ04	uniprotkb:Q0IH16	intact:EBI-995003	intact:EBI-2944308	psi-mi:q6gq04_xenla(display_long)|uniprotkb:cdc27.S(gene name)|psi-mi:cdc27.S(display_short)|uniprotkb:MGC80529(gene name synonym)|uniprotkb:cdc27(gene name synonym)	psi-mi:q0ih16_xenla(display_long)|uniprotkb:anapc5.L(gene name)|psi-mi:anapc5.L(display_short)|uniprotkb:anapc5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zeng et al. (2010)	pubmed:20951947|imex:IM-15161	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2944221|imex:IM-15161-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001085568.1|dip:DIP-61882N	go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0007049"(cell cycle)|go:"GO:0051301"(cell division)|refseq:NP_001090413.1|interpro:IPR026000|rcsb pdb:5BPZ|interpro:IPR016024(Armadillo-type fold)|interpro:IPR037679	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1E.|caution:"The participant EBI-2944289(C6ZIW0) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2010/11/09	2014/10/16	rogid:4kDiMS+d9DpEZyPbzDsa/pzmFB48355	rogid:Sy/qqyKtq1/8zm6zc3tgZPoUqYU8355	intact-crc:B203A7574D135739	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6GQ04	uniprotkb:C6ZIW0	intact:EBI-995003	intact:EBI-2944289	psi-mi:q6gq04_xenla(display_long)|uniprotkb:cdc27.S(gene name)|psi-mi:cdc27.S(display_short)|uniprotkb:MGC80529(gene name synonym)|uniprotkb:cdc27(gene name synonym)	psi-mi:c6ziw0_xenla(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zeng et al. (2010)	pubmed:20951947|imex:IM-15161	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2944221|imex:IM-15161-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001085568.1|dip:DIP-61882N	interpro:IPR044554	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1E.|caution:"The participant EBI-2944289(C6ZIW0) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2010/11/09	2014/10/16	rogid:4kDiMS+d9DpEZyPbzDsa/pzmFB48355	rogid:9hUOVkOf5338bVTijRnGe30duzc8355	intact-crc:B203A7574D135739	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6GQ04	uniprotkb:Q6DFI7	intact:EBI-995003	intact:EBI-2944043	psi-mi:q6gq04_xenla(display_long)|uniprotkb:cdc27.S(gene name)|psi-mi:cdc27.S(display_short)|uniprotkb:MGC80529(gene name synonym)|uniprotkb:cdc27(gene name synonym)	psi-mi:q6dfi7_xenla(display_long)|uniprotkb:cdc16.L(gene name)|psi-mi:cdc16.L(display_short)|uniprotkb:cdc16(gene name synonym)|uniprotkb:cdc16-prov(gene name synonym)|uniprotkb:XELAEV_18012976mg(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zeng et al. (2010)	pubmed:20951947|imex:IM-15161	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2944221|imex:IM-15161-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001085568.1|dip:DIP-61882N	interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001087093.1|dip:DIP-48552N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1E.|caution:"The participant EBI-2944289(C6ZIW0) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2010/11/09	2014/10/16	rogid:4kDiMS+d9DpEZyPbzDsa/pzmFB48355	rogid:i2LJTWv7IUtsUnFOTO9ZHTwaLe48355	intact-crc:B203A7574D135739	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6GQ04	uniprotkb:Q6DDX5	intact:EBI-995003	intact:EBI-2944068	psi-mi:q6gq04_xenla(display_long)|uniprotkb:cdc27.S(gene name)|psi-mi:cdc27.S(display_short)|uniprotkb:MGC80529(gene name synonym)|uniprotkb:cdc27(gene name synonym)	psi-mi:q6ddx5_xenla(display_long)|uniprotkb:anapc7.L(gene name)|psi-mi:anapc7.L(display_short)|uniprotkb:anapc7(gene name synonym)|uniprotkb:anapc7-prov(gene name synonym)|uniprotkb:XELAEV_18007839mg(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zeng et al. (2010)	pubmed:20951947|imex:IM-15161	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2944221|imex:IM-15161-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001085568.1|dip:DIP-61882N	interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001086739.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1E.|caution:"The participant EBI-2944289(C6ZIW0) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2010/11/09	2014/10/16	rogid:4kDiMS+d9DpEZyPbzDsa/pzmFB48355	rogid:LGp1Q+y7InTdYPdPISy+kfBdXFQ8355	intact-crc:B203A7574D135739	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q6GQ04	uniprotkb:Q7T0N9	intact:EBI-995003	intact:EBI-2944054	psi-mi:q6gq04_xenla(display_long)|uniprotkb:cdc27.S(gene name)|psi-mi:cdc27.S(display_short)|uniprotkb:MGC80529(gene name synonym)|uniprotkb:cdc27(gene name synonym)	psi-mi:q7t0n9_xenla(display_long)|uniprotkb:cdc23.L(gene name)|psi-mi:cdc23.L(display_short)|uniprotkb:cdc23(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zeng et al. (2010)	pubmed:20951947|imex:IM-15161	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2944221|imex:IM-15161-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001085568.1|dip:DIP-61882N	go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0007049"(cell cycle)|go:"GO:0030071"(regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|interpro:IPR007192(Cdc23)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|refseq:NP_001079890.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1E.|caution:"The participant EBI-2944289(C6ZIW0) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2010/11/09	2014/10/16	rogid:4kDiMS+d9DpEZyPbzDsa/pzmFB48355	rogid:RFmfdaYEkR7WuhImo3IqAT2OQFw8355	intact-crc:B203A7574D135739	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P30260	uniprotkb:O60566	intact:EBI-994813|uniprotkb:Q16349|uniprotkb:Q96F35|ensembl:ENSP00000066544|uniprotkb:G3V1C4|intact:EBI-10972530	intact:EBI-1001438|uniprotkb:B2R6U0|uniprotkb:B4DL09|uniprotkb:B4DLG3|uniprotkb:Q59HH6|uniprotkb:Q8WV50|intact:EBI-2551047|uniprotkb:O60501|uniprotkb:O60627|uniprotkb:O60758|uniprotkb:O75389|uniprotkb:Q96KM4|ensembl:ENSP00000287598	psi-mi:cdc27_human(display_long)|uniprotkb:CDC27(gene name)|psi-mi:CDC27(display_short)|uniprotkb:D0S1430E(gene name synonym)|uniprotkb:D17S978E(gene name synonym)|uniprotkb:CDC27 homolog(gene name synonym)|uniprotkb:H-NUC(gene name synonym)|uniprotkb:ANAPC3(gene name synonym)|uniprotkb:Anaphase-promoting complex subunit 3(gene name synonym)	psi-mi:bub1b_human(display_long)|uniprotkb:MAD3/BUB1-related protein kinase(gene name synonym)|uniprotkb:Mitotic checkpoint kinase MAD3L(gene name synonym)|uniprotkb:SSK1(gene name synonym)|uniprotkb:BUB1B(gene name)|psi-mi:BUB1B(display_short)|uniprotkb:BUBR1(gene name synonym)|uniprotkb:MAD3L(gene name synonym)|uniprotkb:Protein SSK1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zeng et al. (2010)	pubmed:20951947|imex:IM-15161	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2944421|imex:IM-15161-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000004897(gene)|ensembl:ENST00000066544(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0072686"(mitotic spindle)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|rcsb pdb:3T1N|go:"GO:0005680"(anaphase-promoting complex)|rcsb pdb:4RG6|rcsb pdb:4RG7|rcsb pdb:4RG9|rcsb pdb:4UI9|rcsb pdb:5A31|rcsb pdb:5G04|rcsb pdb:5G05|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5L9T|rcsb pdb:5L9U|rcsb pdb:5LCW|rcsb pdb:6Q6G|rcsb pdb:6Q6H|rcsb pdb:6TLJ|rcsb pdb:6TM5|rcsb pdb:6TNT|reactome:R-HSA-141430|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168|refseq:NP_001107563.1|refseq:NP_001247.3|dip:DIP-36422N	refseq:NP_001202.4|dip:DIP-24203N|ensembl:ENSG00000156970(gene)|ensembl:ENST00000287598(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0000940"(outer kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|mint:O60566|rcsb pdb:2WVI|rcsb pdb:3SI5|rcsb pdb:4GGD|rcsb pdb:5JJA|rcsb pdb:5K6S|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:5SWF|rcsb pdb:6TLJ|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S5D, S5E, S6B.|comment:"proTAME induced significant dissociation of Cdc20/cdc27, but only if SAC proteins were depleted by RNAi (Fig S5D). Hesperadin treatment  led to dissociation of Mad2 and BubR1 from the APC in proTAME-arrested cells (Fig S5E). Hesperadin reduces the amount of Mad2/BubR1 bound to the cdc27 in cells arrested in mitosis with MG132 (Fig S6B)."|antagonist:Hesperadin - a small molecule inhibitor of chromosome alignment and segregation.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2010/11/09	2015/08/14	rogid:YOrJCRal5ZfO7kP2b8FPon0Yytw9606	rogid:EgsQ2ZywEJ+r8hd95vcNEyikMBA9606	intact-crc:145D96D2AA8B18E3|rigid:UiFHGBY3b0LOitk0/asV9zUT83A	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P30260	uniprotkb:Q13257	intact:EBI-994813|uniprotkb:Q16349|uniprotkb:Q96F35|ensembl:ENSP00000066544|uniprotkb:G3V1C4|intact:EBI-10972530	intact:EBI-78203|intact:EBI-28969404|ensembl:ENSP00000296509|uniprotkb:Q53F56|uniprotkb:Q548X9|uniprotkb:Q6IRW7|uniprotkb:Q8IZX3	psi-mi:cdc27_human(display_long)|uniprotkb:CDC27(gene name)|psi-mi:CDC27(display_short)|uniprotkb:D0S1430E(gene name synonym)|uniprotkb:D17S978E(gene name synonym)|uniprotkb:CDC27 homolog(gene name synonym)|uniprotkb:H-NUC(gene name synonym)|uniprotkb:ANAPC3(gene name synonym)|uniprotkb:Anaphase-promoting complex subunit 3(gene name synonym)	psi-mi:md2l1_human(display_long)|uniprotkb:MAD2L1(gene name)|psi-mi:MAD2L1(display_short)|uniprotkb:MAD2(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zeng et al. (2010)	pubmed:20951947|imex:IM-15161	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2944421|imex:IM-15161-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000004897(gene)|ensembl:ENST00000066544(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0072686"(mitotic spindle)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|rcsb pdb:3T1N|go:"GO:0005680"(anaphase-promoting complex)|rcsb pdb:4RG6|rcsb pdb:4RG7|rcsb pdb:4RG9|rcsb pdb:4UI9|rcsb pdb:5A31|rcsb pdb:5G04|rcsb pdb:5G05|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5L9T|rcsb pdb:5L9U|rcsb pdb:5LCW|rcsb pdb:6Q6G|rcsb pdb:6Q6H|rcsb pdb:6TLJ|rcsb pdb:6TM5|rcsb pdb:6TNT|reactome:R-HSA-141430|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168|refseq:NP_001107563.1|refseq:NP_001247.3|dip:DIP-36422N	ensembl:ENSG00000164109(gene)|ensembl:ENST00000296509(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|mint:Q13257|rcsb pdb:1DUJ|rcsb pdb:1GO4|rcsb pdb:1S2H|rcsb pdb:1KLQ|rcsb pdb:2QYF|rcsb pdb:2V64|rcsb pdb:2VFX|rcsb pdb:3GMH|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6TLJ|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENSP00000296509|ensembl:ENST00000333047|ensembl:ENSP00000332295|refseq:NP_002349.1|dip:DIP-29653N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S5D, S5E, S6B.|comment:"proTAME induced significant dissociation of Cdc20/cdc27, but only if SAC proteins were depleted by RNAi (Fig S5D). Hesperadin treatment  led to dissociation of Mad2 and BubR1 from the APC in proTAME-arrested cells (Fig S5E). Hesperadin reduces the amount of Mad2/BubR1 bound to the cdc27 in cells arrested in mitosis with MG132 (Fig S6B)."|antagonist:Hesperadin - a small molecule inhibitor of chromosome alignment and segregation.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2010/11/09	2015/08/14	rogid:YOrJCRal5ZfO7kP2b8FPon0Yytw9606	rogid:FyL1tmJllOZ4gQvwWb96aV9PMFw9606	intact-crc:145D96D2AA8B18E3|rigid:UiFHGBY3b0LOitk0/asV9zUT83A	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P30260	uniprotkb:Q12834	intact:EBI-994813|uniprotkb:Q16349|uniprotkb:Q96F35|ensembl:ENSP00000066544|uniprotkb:G3V1C4|intact:EBI-10972530	intact:EBI-367462|uniprotkb:Q5JUY4|uniprotkb:Q9BW56|uniprotkb:Q9UQI9|uniprotkb:B2R6Z6|uniprotkb:D3DPJ1|ensembl:ENSP00000308450|ensembl:ENSP00000361540	psi-mi:cdc27_human(display_long)|uniprotkb:CDC27(gene name)|psi-mi:CDC27(display_short)|uniprotkb:D0S1430E(gene name synonym)|uniprotkb:D17S978E(gene name synonym)|uniprotkb:CDC27 homolog(gene name synonym)|uniprotkb:H-NUC(gene name synonym)|uniprotkb:ANAPC3(gene name synonym)|uniprotkb:Anaphase-promoting complex subunit 3(gene name synonym)	psi-mi:cdc20_human(display_long)|uniprotkb:CDC20(gene name)|psi-mi:CDC20(display_short)|uniprotkb:p55CDC(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zeng et al. (2010)	pubmed:20951947|imex:IM-15161	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2944421|imex:IM-15161-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000004897(gene)|ensembl:ENST00000066544(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0072686"(mitotic spindle)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|rcsb pdb:3T1N|go:"GO:0005680"(anaphase-promoting complex)|rcsb pdb:4RG6|rcsb pdb:4RG7|rcsb pdb:4RG9|rcsb pdb:4UI9|rcsb pdb:5A31|rcsb pdb:5G04|rcsb pdb:5G05|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5L9T|rcsb pdb:5L9U|rcsb pdb:5LCW|rcsb pdb:6Q6G|rcsb pdb:6Q6H|rcsb pdb:6TLJ|rcsb pdb:6TM5|rcsb pdb:6TNT|reactome:R-HSA-141430|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168|refseq:NP_001107563.1|refseq:NP_001247.3|dip:DIP-36422N	rcsb pdb:6Q6H|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174048|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176417|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-5689880|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-983168|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051301"(cell division)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q12834|rcsb pdb:4GGA|rcsb pdb:4GGC|rcsb pdb:4GGD|rcsb pdb:4N14|rcsb pdb:5G04|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6Q6G|refseq:NP_001246.2|ensembl:ENSG00000117399(gene)|ensembl:ENST00000310955(transcript)|ensembl:ENST00000372462(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-29655N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S5D, S5E, S6B.|comment:"proTAME induced significant dissociation of Cdc20/cdc27, but only if SAC proteins were depleted by RNAi (Fig S5D). Hesperadin treatment  led to dissociation of Mad2 and BubR1 from the APC in proTAME-arrested cells (Fig S5E). Hesperadin reduces the amount of Mad2/BubR1 bound to the cdc27 in cells arrested in mitosis with MG132 (Fig S6B)."|antagonist:Hesperadin - a small molecule inhibitor of chromosome alignment and segregation.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2010/11/09	2015/08/14	rogid:YOrJCRal5ZfO7kP2b8FPon0Yytw9606	rogid:15j9Heovw6LpbClp5kT9Wz6a88A9606	intact-crc:145D96D2AA8B18E3|rigid:UiFHGBY3b0LOitk0/asV9zUT83A	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)