#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q80U63 uniprotkb:Q3TVW5 intact:EBI-8437663|intact:MINT-8057620|uniprotkb:Q8R535|uniprotkb:A2A7Y7|uniprotkb:Q80XK3|uniprotkb:Q8BHF0|uniprotkb:Q8BKV5|uniprotkb:A8Y5E4|uniprotkb:Q3V3B8|uniprotkb:Q923X2|uniprotkb:Q80WP4|ensembl:ENSMUSP00000030884|ensembl:ENSMUSP00000101340|ensembl:ENSMUSP00000101341 intact:EBI-8437711|uniprotkb:Q8C459|uniprotkb:Q9CTP0|intact:UNK-5363398|uniprotkb:Q80ZV6|ensembl:ENSMUSP00000092009 psi-mi:mfn2_mouse(display_long)|uniprotkb:Mfn2(gene name)|psi-mi:Mfn2(display_short)|uniprotkb:Kiaa0214(gene name synonym)|uniprotkb:Marf(gene name synonym)|uniprotkb:Hypertension-related protein 1(gene name synonym)|uniprotkb:Mitochondrial assembly regulatory factor(gene name synonym)|uniprotkb:Transmembrane GTPase MFN2(gene name synonym) psi-mi:tchp_mouse(display_long)|uniprotkb:Mitochondrial protein with oncostatic activity(gene name synonym)|uniprotkb:Tchp(gene name)|psi-mi:Tchp(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Cerqua et al. (2010) pubmed:20930847|imex:IM-15186|mint:MINT-8052996|doi:10.1038/embor.2010.151 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8437706|mint:MINT-8053002|imex:IM-15186-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001272849.1|refseq:NP_001272850.1|refseq:NP_001272851.1|refseq:NP_001272852.1|refseq:NP_573464.2|dip:DIP-60970N|refseq:XP_006538672.1|refseq:XP_006538673.1|refseq:XP_006538674.1|ensembl:ENSMUSG00000029020(gene)|ensembl:ENSMUST00000030884(transcript)|ensembl:ENSMUST00000105715(transcript)|ensembl:ENSMUST00000105716(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031306"(intrinsic component of mitochondrial outer membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0051020"(GTPase binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR006884(Fzo-like conserved region)|interpro:IPR022812|interpro:IPR027089|interpro:IPR027094|interpro:IPR027417|interpro:IPR030381|mint:Q80U63|reactome:R-MMU-5205685|reactome:R-MMU-9013419|reactome:R-MMU-983231|mint:MINT-8053005(identity) refseq:NP_084268.2|refseq:XP_006530573.1|ensembl:ENSMUSG00000002486(gene)|ensembl:ENSMUST00000094441(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0030030"(cell projection organization)|go:"GO:0030057"(desmosome)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0045095"(keratin filament)|go:"GO:0045179"(apical cortex)|go:"GO:0097539"(ciliary transition fiber)|go:"GO:1902018"(negative regulation of cilium assembly)|interpro:IPR026773|interpro:IPR043596|interpro:IPR043597|mint:MINT-8053004(identity) - comment:mint comment:mint|function:May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells figure legend:f3b|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts) - 2010/11/03 2014/10/16 rogid:7jDQScOD9jxw/I3zBy5mnbjOF0M10090 rogid:qHq/vgUVTrTPnqhaALiLQk5VmP810090 intact-crc:A5DB70680338880E|rigid:etciefrjBPKRx4H52rubk99FjNk false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0113"(western blot) uniprotkb:O95140 uniprotkb:Q9BT92 intact:EBI-3324756|uniprotkb:A8K1B3|uniprotkb:O95572|uniprotkb:Q5JXC3|uniprotkb:Q5JXC4|uniprotkb:Q9H131|uniprotkb:Q9NSX8|ensembl:ENSP00000235329|ensembl:ENSP00000416338|ensembl:ENSP00000502151|ensembl:ENSP00000502185|ensembl:ENSP00000502362|ensembl:ENSP00000502404|ensembl:ENSP00000502623|ensembl:ENSP00000501646|ensembl:ENSP00000501716|ensembl:ENSP00000501776 intact:EBI-740781|uniprotkb:Q8NAG0|ensembl:ENSP00000324404|ensembl:ENSP00000384520|ensembl:ENSP00000440838 psi-mi:mfn2_human(display_long)|uniprotkb:MFN2(gene name)|psi-mi:MFN2(display_short)|uniprotkb:CPRP1(gene name synonym)|uniprotkb:KIAA0214(gene name synonym)|uniprotkb:Transmembrane GTPase MFN2(gene name synonym) psi-mi:tchp_human(display_long)|uniprotkb:Tumor suppressor protein(gene name synonym)|uniprotkb:TCHP(gene name)|psi-mi:TCHP(display_short)|uniprotkb:Mitochondrial protein with oncostatic activity(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Cerqua et al. (2010) pubmed:20930847|imex:IM-15186|mint:MINT-8052996|doi:10.1038/embor.2010.151 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8437929|mint:MINT-8057607|imex:IM-15186-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001121132.1|refseq:NP_055689.1|refseq:XP_005263600.1|refseq:XP_005263602.1|refseq:XP_005263604.1|refseq:XP_005263605.1|ensembl:ENSG00000116688(gene)|ensembl:ENST00000235329(transcript)|ensembl:ENST00000444836(transcript)|ensembl:ENST00000674548(transcript)|ensembl:ENST00000674817(transcript)|ensembl:ENST00000674910(transcript)|ensembl:ENST00000675053(transcript)|ensembl:ENST00000675113(transcript)|ensembl:ENST00000675231(transcript)|ensembl:ENST00000675919(transcript)|ensembl:ENST00000676293(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031306"(intrinsic component of mitochondrial outer membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR006884(Fzo-like conserved region)|interpro:IPR022812|interpro:IPR027089|interpro:IPR027094|interpro:IPR027417|interpro:IPR030381|mint:O95140|rcsb pdb:6JFK|rcsb pdb:6JFL|rcsb pdb:6JFM|reactome:R-HSA-5205685|reactome:R-HSA-9013419|reactome:R-HSA-983231|dip:DIP-42832N|mint:MINT-8057611(identity) refseq:NP_001137324.1|refseq:NP_115676.1|go:"GO:1902018"(negative regulation of cilium assembly)|interpro:IPR026773|interpro:IPR043596|interpro:IPR043597|ensembl:ENSG00000139437(gene)|ensembl:ENST00000312777(transcript)|ensembl:ENST00000405876(transcript)|ensembl:ENST00000544838(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0030030"(cell projection organization)|go:"GO:0030057"(desmosome)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0045095"(keratin filament)|go:"GO:0045179"(apical cortex)|refseq:XP_011537138.1|refseq:XP_011537139.1|mint:MINT-8057609(identity) - - - figure legend:f3a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2010/11/03 2014/10/16 rogid:E54l4ZR9fs6qvZJczOOibxVlJx49606 rogid:VjRRssFtp+7aVZIXW0BDz+FZMQw9606 intact-crc:11195A73269D4DA7|rigid:yzSxm6pHzlrwxWyN1rEtqVRDQSU false green fluorescent protein tag:?-?(MINT-8057617) - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot)