#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q96D31	uniprotkb:O75185	intact:EBI-2291476|uniprotkb:Q3MHV3|uniprotkb:Q6DHX2|uniprotkb:Q96BP7|uniprotkb:Q96K71|ensembl:ENSP00000482568	intact:EBI-2939806|ensembl:ENSP00000262429|uniprotkb:B4DU76|uniprotkb:Q5S053|uniprotkb:Q68CQ2|uniprotkb:E7ES94|uniprotkb:Q5HYC3	psi-mi:crcm1_human(display_long)|uniprotkb:ORAI1(gene name)|psi-mi:ORAI1(display_short)|uniprotkb:CRACM1(gene name synonym)|uniprotkb:TMEM142A(gene name synonym)|uniprotkb:Protein orai-1(gene name synonym)|uniprotkb:Transmembrane protein 142A(gene name synonym)	psi-mi:at2c2_human(display_long)|uniprotkb:ATP2C2(gene name)|psi-mi:ATP2C2(display_short)|uniprotkb:KIAA0703(gene name synonym)|uniprotkb:SPCA2(gene name synonym)|uniprotkb:"Ca(2+)/Mn(2+)-ATPase 2C2"(gene name synonym)|uniprotkb:"Secretory pathway Ca(2+)-transporting ATPase type 2"(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Feng et al. (2010)	pubmed:20887894|imex:IM-15156	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2939841|imex:IM-15156-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116179.2|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR012446(Protein of unknown function DUF1650)|interpro:IPR038350|rcsb pdb:2MAK|rcsb pdb:4EHQ|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|ensembl:ENSG00000276045(gene)|ensembl:ENST00000617316(transcript)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070509"(calcium ion import)|dip:DIP-46289N	interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006413(Calcium-transporting P-type ATPase, PMR1-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR030334|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|ensembl:ENSG00000064270(gene)|ensembl:ENST00000262429(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006828"(manganese ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015410"(ABC-type manganese transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0140613"(P-type manganese transporter activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|refseq:NP_055676.3|refseq:NP_001273456.2|refseq:NP_001278383.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2010/11/02	2018/09/18	rogid:VXcTrF/8sZA01XGUFZwvu75L7Kw9606	rogid:9SWdgUO9aTf4/Bed+f8uYiEs+9I9606	intact-crc:81016540E17650AA|rigid:hNXCBjImzEkxMDxuYdSH+PqEF+k	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96D31	uniprotkb:O75185	intact:EBI-2291476|uniprotkb:Q3MHV3|uniprotkb:Q6DHX2|uniprotkb:Q96BP7|uniprotkb:Q96K71|ensembl:ENSP00000482568	intact:EBI-2939806|ensembl:ENSP00000262429|uniprotkb:B4DU76|uniprotkb:Q5S053|uniprotkb:Q68CQ2|uniprotkb:E7ES94|uniprotkb:Q5HYC3	psi-mi:crcm1_human(display_long)|uniprotkb:ORAI1(gene name)|psi-mi:ORAI1(display_short)|uniprotkb:CRACM1(gene name synonym)|uniprotkb:TMEM142A(gene name synonym)|uniprotkb:Protein orai-1(gene name synonym)|uniprotkb:Transmembrane protein 142A(gene name synonym)	psi-mi:at2c2_human(display_long)|uniprotkb:ATP2C2(gene name)|psi-mi:ATP2C2(display_short)|uniprotkb:KIAA0703(gene name synonym)|uniprotkb:SPCA2(gene name synonym)|uniprotkb:"Ca(2+)/Mn(2+)-ATPase 2C2"(gene name synonym)|uniprotkb:"Secretory pathway Ca(2+)-transporting ATPase type 2"(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Feng et al. (2010)	pubmed:20887894|imex:IM-15156	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2939976|imex:IM-15156-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116179.2|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR012446(Protein of unknown function DUF1650)|interpro:IPR038350|rcsb pdb:2MAK|rcsb pdb:4EHQ|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|ensembl:ENSG00000276045(gene)|ensembl:ENST00000617316(transcript)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070509"(calcium ion import)|dip:DIP-46289N	interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006413(Calcium-transporting P-type ATPase, PMR1-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR030334|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|ensembl:ENSG00000064270(gene)|ensembl:ENST00000262429(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006828"(manganese ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015410"(ABC-type manganese transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0140613"(P-type manganese transporter activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|refseq:NP_055676.3|refseq:NP_001273456.2|refseq:NP_001278383.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/11/02	2018/09/18	rogid:VXcTrF/8sZA01XGUFZwvu75L7Kw9606	rogid:9SWdgUO9aTf4/Bed+f8uYiEs+9I9606	intact-crc:5FA5A4C2E01B1931|rigid:hNXCBjImzEkxMDxuYdSH+PqEF+k	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13586	uniprotkb:P98194	intact:EBI-448878|uniprotkb:Q8N382|ensembl:ENSP00000300737|uniprotkb:E9PQJ4	intact:EBI-2939877|ensembl:ENSP00000395809|ensembl:ENSP00000424783|ensembl:ENSP00000427461|uniprotkb:B2RAT7|uniprotkb:O76005|uniprotkb:Q86V72|uniprotkb:Q86V73|uniprotkb:Q8N6V1|uniprotkb:Q8NCJ7|uniprotkb:B4DSW3|uniprotkb:B7Z3X9|uniprotkb:G3XAH8|uniprotkb:G8JLN9	psi-mi:stim1_human(display_long)|uniprotkb:STIM1(gene name)|psi-mi:STIM1(display_short)|uniprotkb:GOK(gene name synonym)	psi-mi:at2c1_human(display_long)|uniprotkb:ATP2C1(gene name)|psi-mi:ATP2C1(display_short)|uniprotkb:KIAA1347(gene name synonym)|uniprotkb:PMR1L(gene name synonym)|uniprotkb:"ATP-dependent Ca(2+) pump PMR1"(gene name synonym)|uniprotkb:"Ca(2+)/Mn(2+)-ATPase 2C1"(gene name synonym)|uniprotkb:"Secretory pathway Ca(2+)-transporting ATPase type 1"(gene name synonym)|uniprotkb:HUSSY-28(orf name)	psi-mi:"MI:0663"(confocal microscopy)	Feng et al. (2010)	pubmed:20887894|imex:IM-15156	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2939954|imex:IM-15156-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003147.2|ensembl:ENSG00000167323(gene)|ensembl:ENST00000300737(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070166"(enamel mineralization)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030463|interpro:IPR032393|interpro:IPR037608|interpro:IPR037609|rcsb pdb:2K60|rcsb pdb:2MAJ|rcsb pdb:2MAK|rcsb pdb:3TEQ|rcsb pdb:4O9B|rcsb pdb:6YEL|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|refseq:NP_001264891.1|dip:DIP-31121N	ensembl:ENSG00000017260(gene)|ensembl:ENST00000428331(transcript)|ensembl:ENST00000508532(transcript)|ensembl:ENST00000510168(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0030026"(cellular manganese ion homeostasis)|go:"GO:0008544"(epidermis development)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0030145"(manganese ion binding)|go:"GO:0015410"(ABC-type manganese transporter activity)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032468"(Golgi calcium ion homeostasis)|go:"GO:0032472"(Golgi calcium ion transport)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033106"(cis-Golgi network membrane)|go:"GO:0042998"(positive regulation of Golgi to plasma membrane protein transport)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0098629"(trans-Golgi network membrane organization)|go:"GO:0140613"(P-type manganese transporter activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006413(Calcium-transporting P-type ATPase, PMR1-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR030336|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|refseq:NP_001001485.1|refseq:NP_001001486.1|refseq:NP_001001487.1|refseq:NP_001186108.1|refseq:NP_001186109.1|refseq:NP_001186110.1|refseq:NP_001186111.1|refseq:NP_001186112.1|refseq:NP_001186113.1|refseq:NP_001186114.1|refseq:NP_055197.2|refseq:XP_016861653.1|refseq:XP_005247412.1|refseq:XP_005247413.1	psi-mi:"MI:0469"(intact)	-	-	dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/11/02	2014/10/16	rogid:GQh8kgCwqrcx7VtJdv63pW1eg/U9606	rogid:jPAb8dnATDdbBvc++3El2w2Zaeg9606	intact-crc:68C61A453DD833FF|rigid:C0PGZm6GmD2w6R6oYiq51+bxWBU	false	myc tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:O75185	uniprotkb:Q96D31	intact:EBI-2939806|ensembl:ENSP00000262429|uniprotkb:B4DU76|uniprotkb:Q5S053|uniprotkb:Q68CQ2|uniprotkb:E7ES94|uniprotkb:Q5HYC3	intact:EBI-2291476|uniprotkb:Q3MHV3|uniprotkb:Q6DHX2|uniprotkb:Q96BP7|uniprotkb:Q96K71|ensembl:ENSP00000482568	psi-mi:at2c2_human(display_long)|uniprotkb:ATP2C2(gene name)|psi-mi:ATP2C2(display_short)|uniprotkb:KIAA0703(gene name synonym)|uniprotkb:SPCA2(gene name synonym)|uniprotkb:"Ca(2+)/Mn(2+)-ATPase 2C2"(gene name synonym)|uniprotkb:"Secretory pathway Ca(2+)-transporting ATPase type 2"(gene name synonym)	psi-mi:crcm1_human(display_long)|uniprotkb:ORAI1(gene name)|psi-mi:ORAI1(display_short)|uniprotkb:CRACM1(gene name synonym)|uniprotkb:TMEM142A(gene name synonym)|uniprotkb:Protein orai-1(gene name synonym)|uniprotkb:Transmembrane protein 142A(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Feng et al. (2010)	pubmed:20887894|imex:IM-15156	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2939987|imex:IM-15156-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006413(Calcium-transporting P-type ATPase, PMR1-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR030334|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|ensembl:ENSG00000064270(gene)|ensembl:ENST00000262429(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006828"(manganese ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015410"(ABC-type manganese transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0140613"(P-type manganese transporter activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|refseq:NP_055676.3|refseq:NP_001273456.2|refseq:NP_001278383.1	refseq:NP_116179.2|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR012446(Protein of unknown function DUF1650)|interpro:IPR038350|rcsb pdb:2MAK|rcsb pdb:4EHQ|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|ensembl:ENSG00000276045(gene)|ensembl:ENST00000617316(transcript)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070509"(calcium ion import)|dip:DIP-46289N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 5D|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/11/02	2018/09/18	rogid:9SWdgUO9aTf4/Bed+f8uYiEs+9I9606	rogid:VXcTrF/8sZA01XGUFZwvu75L7Kw9606	intact-crc:C761EBE5174680FC|rigid:hNXCBjImzEkxMDxuYdSH+PqEF+k	false	ha tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:O75185	uniprotkb:Q96D31	intact:EBI-2939806|ensembl:ENSP00000262429|uniprotkb:B4DU76|uniprotkb:Q5S053|uniprotkb:Q68CQ2|uniprotkb:E7ES94|uniprotkb:Q5HYC3	intact:EBI-2291476|uniprotkb:Q3MHV3|uniprotkb:Q6DHX2|uniprotkb:Q96BP7|uniprotkb:Q96K71|ensembl:ENSP00000482568	psi-mi:at2c2_human(display_long)|uniprotkb:ATP2C2(gene name)|psi-mi:ATP2C2(display_short)|uniprotkb:KIAA0703(gene name synonym)|uniprotkb:SPCA2(gene name synonym)|uniprotkb:"Ca(2+)/Mn(2+)-ATPase 2C2"(gene name synonym)|uniprotkb:"Secretory pathway Ca(2+)-transporting ATPase type 2"(gene name synonym)	psi-mi:crcm1_human(display_long)|uniprotkb:ORAI1(gene name)|psi-mi:ORAI1(display_short)|uniprotkb:CRACM1(gene name synonym)|uniprotkb:TMEM142A(gene name synonym)|uniprotkb:Protein orai-1(gene name synonym)|uniprotkb:Transmembrane protein 142A(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Feng et al. (2010)	pubmed:20887894|imex:IM-15156	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2940169|imex:IM-15156-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006413(Calcium-transporting P-type ATPase, PMR1-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR030334|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|ensembl:ENSG00000064270(gene)|ensembl:ENST00000262429(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006828"(manganese ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015410"(ABC-type manganese transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0140613"(P-type manganese transporter activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|refseq:NP_055676.3|refseq:NP_001273456.2|refseq:NP_001278383.1	refseq:NP_116179.2|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR012446(Protein of unknown function DUF1650)|interpro:IPR038350|rcsb pdb:2MAK|rcsb pdb:4EHQ|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|ensembl:ENSG00000276045(gene)|ensembl:ENST00000617316(transcript)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070509"(calcium ion import)|dip:DIP-46289N	go:"GO:0005886"(plasma membrane)	-	-	figure legend:Fig. 7B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/11/02	2018/09/18	rogid:9SWdgUO9aTf4/Bed+f8uYiEs+9I9606	rogid:VXcTrF/8sZA01XGUFZwvu75L7Kw9606	intact-crc:6083E91F8AF3A467|rigid:hNXCBjImzEkxMDxuYdSH+PqEF+k	false	glutathione s tranferase tag:?-?|sufficient binding region:923-946	myc tag:?-?	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:O75185	uniprotkb:Q96D31	intact:EBI-2939806|ensembl:ENSP00000262429|uniprotkb:B4DU76|uniprotkb:Q5S053|uniprotkb:Q68CQ2|uniprotkb:E7ES94|uniprotkb:Q5HYC3	intact:EBI-2291476|uniprotkb:Q3MHV3|uniprotkb:Q6DHX2|uniprotkb:Q96BP7|uniprotkb:Q96K71|ensembl:ENSP00000482568	psi-mi:at2c2_human(display_long)|uniprotkb:ATP2C2(gene name)|psi-mi:ATP2C2(display_short)|uniprotkb:KIAA0703(gene name synonym)|uniprotkb:SPCA2(gene name synonym)|uniprotkb:"Ca(2+)/Mn(2+)-ATPase 2C2"(gene name synonym)|uniprotkb:"Secretory pathway Ca(2+)-transporting ATPase type 2"(gene name synonym)	psi-mi:crcm1_human(display_long)|uniprotkb:ORAI1(gene name)|psi-mi:ORAI1(display_short)|uniprotkb:CRACM1(gene name synonym)|uniprotkb:TMEM142A(gene name synonym)|uniprotkb:Protein orai-1(gene name synonym)|uniprotkb:Transmembrane protein 142A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Feng et al. (2010)	pubmed:20887894|imex:IM-15156	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2939859|imex:IM-15156-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006413(Calcium-transporting P-type ATPase, PMR1-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR030334|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|ensembl:ENSG00000064270(gene)|ensembl:ENST00000262429(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006828"(manganese ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015410"(ABC-type manganese transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0140613"(P-type manganese transporter activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|refseq:NP_055676.3|refseq:NP_001273456.2|refseq:NP_001278383.1	refseq:NP_116179.2|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR012446(Protein of unknown function DUF1650)|interpro:IPR038350|rcsb pdb:2MAK|rcsb pdb:4EHQ|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|ensembl:ENSG00000276045(gene)|ensembl:ENST00000617316(transcript)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070509"(calcium ion import)|dip:DIP-46289N	go:"GO:0005886"(plasma membrane)	-	-	figure legend:Supp. Fig. 5B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/11/02	2018/09/18	rogid:9SWdgUO9aTf4/Bed+f8uYiEs+9I9606	rogid:VXcTrF/8sZA01XGUFZwvu75L7Kw9606	intact-crc:E8AC00E35E3546E2|rigid:hNXCBjImzEkxMDxuYdSH+PqEF+k	false	ha tag:?-?	myc tag:?-?|biotin tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O75185	uniprotkb:Q96D31	intact:EBI-2939806|ensembl:ENSP00000262429|uniprotkb:B4DU76|uniprotkb:Q5S053|uniprotkb:Q68CQ2|uniprotkb:E7ES94|uniprotkb:Q5HYC3	intact:EBI-2291476|uniprotkb:Q3MHV3|uniprotkb:Q6DHX2|uniprotkb:Q96BP7|uniprotkb:Q96K71|ensembl:ENSP00000482568	psi-mi:at2c2_human(display_long)|uniprotkb:ATP2C2(gene name)|psi-mi:ATP2C2(display_short)|uniprotkb:KIAA0703(gene name synonym)|uniprotkb:SPCA2(gene name synonym)|uniprotkb:"Ca(2+)/Mn(2+)-ATPase 2C2"(gene name synonym)|uniprotkb:"Secretory pathway Ca(2+)-transporting ATPase type 2"(gene name synonym)	psi-mi:crcm1_human(display_long)|uniprotkb:ORAI1(gene name)|psi-mi:ORAI1(display_short)|uniprotkb:CRACM1(gene name synonym)|uniprotkb:TMEM142A(gene name synonym)|uniprotkb:Protein orai-1(gene name synonym)|uniprotkb:Transmembrane protein 142A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Feng et al. (2010)	pubmed:20887894|imex:IM-15156	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2940004|imex:IM-15156-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006413(Calcium-transporting P-type ATPase, PMR1-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR030334|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|ensembl:ENSG00000064270(gene)|ensembl:ENST00000262429(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006828"(manganese ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015410"(ABC-type manganese transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0140613"(P-type manganese transporter activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|refseq:NP_055676.3|refseq:NP_001273456.2|refseq:NP_001278383.1	refseq:NP_116179.2|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR012446(Protein of unknown function DUF1650)|interpro:IPR038350|rcsb pdb:2MAK|rcsb pdb:4EHQ|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|ensembl:ENSG00000276045(gene)|ensembl:ENST00000617316(transcript)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070509"(calcium ion import)|dip:DIP-46289N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 5D|comment:Interaction between SPCA2 and Orai1 was not affected by ER Ca2+ store depletion by thapsigargin.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/11/02	2018/09/18	rogid:9SWdgUO9aTf4/Bed+f8uYiEs+9I9606	rogid:VXcTrF/8sZA01XGUFZwvu75L7Kw9606	intact-crc:EDB0B3C0B8EAEBD3|rigid:hNXCBjImzEkxMDxuYdSH+PqEF+k	false	ha tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96D31	intact:EBI-2940015	intact:EBI-2291476|uniprotkb:Q3MHV3|uniprotkb:Q6DHX2|uniprotkb:Q96BP7|uniprotkb:Q96K71|ensembl:ENSP00000482568	-	psi-mi:crcm1_human(display_long)|uniprotkb:ORAI1(gene name)|psi-mi:ORAI1(display_short)|uniprotkb:CRACM1(gene name synonym)|uniprotkb:TMEM142A(gene name synonym)|uniprotkb:Protein orai-1(gene name synonym)|uniprotkb:Transmembrane protein 142A(gene name synonym)	psi-mi:atp2c1_c2_n2(display_short)|psi-mi:EBI-2940015(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Feng et al. (2010)	pubmed:20887894|imex:IM-15156	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2940028|imex:IM-15156-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116179.2|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR012446(Protein of unknown function DUF1650)|interpro:IPR038350|rcsb pdb:2MAK|rcsb pdb:4EHQ|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|ensembl:ENSG00000276045(gene)|ensembl:ENST00000617316(transcript)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070509"(calcium ion import)|dip:DIP-46289N	-	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Fig. 5B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/11/02	2014/10/16	rogid:VXcTrF/8sZA01XGUFZwvu75L7Kw9606	rogid:vDIuuEDHme29vHimJBRTbBt7oFA9606	intact-crc:628D92FCBF873C31|rigid:c8mELpGEJJdnIOmy6dVWMIDHWzU	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
intact:EBI-2940018	uniprotkb:Q96D31	-	intact:EBI-2291476|uniprotkb:Q3MHV3|uniprotkb:Q6DHX2|uniprotkb:Q96BP7|uniprotkb:Q96K71|ensembl:ENSP00000482568	psi-mi:atp2c1_c2_c1(display_short)|psi-mi:EBI-2940018(display_long)	psi-mi:crcm1_human(display_long)|uniprotkb:ORAI1(gene name)|psi-mi:ORAI1(display_short)|uniprotkb:CRACM1(gene name synonym)|uniprotkb:TMEM142A(gene name synonym)|uniprotkb:Protein orai-1(gene name synonym)|uniprotkb:Transmembrane protein 142A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Feng et al. (2010)	pubmed:20887894|imex:IM-15156	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2940036|imex:IM-15156-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_116179.2|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR012446(Protein of unknown function DUF1650)|interpro:IPR038350|rcsb pdb:2MAK|rcsb pdb:4EHQ|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|ensembl:ENSG00000276045(gene)|ensembl:ENST00000617316(transcript)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070509"(calcium ion import)|dip:DIP-46289N	psi-mi:"MI:0469"(intact)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Fig. 5B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/11/02	2014/10/16	rogid:5uhZXJ+itD9e2HW9LIrHisA9XQE9606	rogid:VXcTrF/8sZA01XGUFZwvu75L7Kw9606	intact-crc:D6638B0413914FC1|rigid:/z4YoEMXtF5eNKuIHNbO+UJ+Zt0	false	ha tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O75185	uniprotkb:Q96D31	intact:EBI-2939806|ensembl:ENSP00000262429|uniprotkb:B4DU76|uniprotkb:Q5S053|uniprotkb:Q68CQ2|uniprotkb:E7ES94|uniprotkb:Q5HYC3	intact:EBI-2291476|uniprotkb:Q3MHV3|uniprotkb:Q6DHX2|uniprotkb:Q96BP7|uniprotkb:Q96K71|ensembl:ENSP00000482568	psi-mi:at2c2_human(display_long)|uniprotkb:ATP2C2(gene name)|psi-mi:ATP2C2(display_short)|uniprotkb:KIAA0703(gene name synonym)|uniprotkb:SPCA2(gene name synonym)|uniprotkb:"Ca(2+)/Mn(2+)-ATPase 2C2"(gene name synonym)|uniprotkb:"Secretory pathway Ca(2+)-transporting ATPase type 2"(gene name synonym)	psi-mi:crcm1_human(display_long)|uniprotkb:ORAI1(gene name)|psi-mi:ORAI1(display_short)|uniprotkb:CRACM1(gene name synonym)|uniprotkb:TMEM142A(gene name synonym)|uniprotkb:Protein orai-1(gene name synonym)|uniprotkb:Transmembrane protein 142A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Feng et al. (2010)	pubmed:20887894|imex:IM-15156	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2940051|imex:IM-15156-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006413(Calcium-transporting P-type ATPase, PMR1-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR030334|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|ensembl:ENSG00000064270(gene)|ensembl:ENST00000262429(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006828"(manganese ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015410"(ABC-type manganese transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0140613"(P-type manganese transporter activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|refseq:NP_055676.3|refseq:NP_001273456.2|refseq:NP_001278383.1	refseq:NP_116179.2|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR012446(Protein of unknown function DUF1650)|interpro:IPR038350|rcsb pdb:2MAK|rcsb pdb:4EHQ|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|ensembl:ENSG00000276045(gene)|ensembl:ENST00000617316(transcript)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070509"(calcium ion import)|dip:DIP-46289N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5D, 5E, 5F, 5G|caution:Identity of residues to which mutations were altered is not given in text.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/11/02	2018/09/18	rogid:9SWdgUO9aTf4/Bed+f8uYiEs+9I9606	rogid:VXcTrF/8sZA01XGUFZwvu75L7Kw9606	intact-crc:39641257A01685E6|rigid:hNXCBjImzEkxMDxuYdSH+PqEF+k	false	glutathione s tranferase tag:?-?|sufficient binding region:67-106(IPR004014)|mutation decreasing interaction:78-78|mutation decreasing interaction:71-71|mutation decreasing interaction:75-75|mutation decreasing interaction:95-95	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O75185	uniprotkb:Q96D31	intact:EBI-2939806|ensembl:ENSP00000262429|uniprotkb:B4DU76|uniprotkb:Q5S053|uniprotkb:Q68CQ2|uniprotkb:E7ES94|uniprotkb:Q5HYC3	intact:EBI-2291476|uniprotkb:Q3MHV3|uniprotkb:Q6DHX2|uniprotkb:Q96BP7|uniprotkb:Q96K71|ensembl:ENSP00000482568	psi-mi:at2c2_human(display_long)|uniprotkb:ATP2C2(gene name)|psi-mi:ATP2C2(display_short)|uniprotkb:KIAA0703(gene name synonym)|uniprotkb:SPCA2(gene name synonym)|uniprotkb:"Ca(2+)/Mn(2+)-ATPase 2C2"(gene name synonym)|uniprotkb:"Secretory pathway Ca(2+)-transporting ATPase type 2"(gene name synonym)	psi-mi:crcm1_human(display_long)|uniprotkb:ORAI1(gene name)|psi-mi:ORAI1(display_short)|uniprotkb:CRACM1(gene name synonym)|uniprotkb:TMEM142A(gene name synonym)|uniprotkb:Protein orai-1(gene name synonym)|uniprotkb:Transmembrane protein 142A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Feng et al. (2010)	pubmed:20887894|imex:IM-15156	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2940126|imex:IM-15156-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006413(Calcium-transporting P-type ATPase, PMR1-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR030334|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|ensembl:ENSG00000064270(gene)|ensembl:ENST00000262429(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006828"(manganese ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015410"(ABC-type manganese transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0140613"(P-type manganese transporter activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|refseq:NP_055676.3|refseq:NP_001273456.2|refseq:NP_001278383.1	refseq:NP_116179.2|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR012446(Protein of unknown function DUF1650)|interpro:IPR038350|rcsb pdb:2MAK|rcsb pdb:4EHQ|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|ensembl:ENSG00000276045(gene)|ensembl:ENST00000617316(transcript)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070509"(calcium ion import)|dip:DIP-46289N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 6E, 6G|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/11/02	2018/09/18	rogid:9SWdgUO9aTf4/Bed+f8uYiEs+9I9606	rogid:VXcTrF/8sZA01XGUFZwvu75L7Kw9606	intact-crc:A3C9DF8559E7FDCB|rigid:hNXCBjImzEkxMDxuYdSH+PqEF+k	false	ha tag:?-?	glutathione s tranferase tag:?-?|mutation decreasing interaction:273-273|sufficient binding region:48-91|sufficient binding region:255-301	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O75185	uniprotkb:Q96D31	intact:EBI-2939806|ensembl:ENSP00000262429|uniprotkb:B4DU76|uniprotkb:Q5S053|uniprotkb:Q68CQ2|uniprotkb:E7ES94|uniprotkb:Q5HYC3	intact:EBI-2291476|uniprotkb:Q3MHV3|uniprotkb:Q6DHX2|uniprotkb:Q96BP7|uniprotkb:Q96K71|ensembl:ENSP00000482568	psi-mi:at2c2_human(display_long)|uniprotkb:ATP2C2(gene name)|psi-mi:ATP2C2(display_short)|uniprotkb:KIAA0703(gene name synonym)|uniprotkb:SPCA2(gene name synonym)|uniprotkb:"Ca(2+)/Mn(2+)-ATPase 2C2"(gene name synonym)|uniprotkb:"Secretory pathway Ca(2+)-transporting ATPase type 2"(gene name synonym)	psi-mi:crcm1_human(display_long)|uniprotkb:ORAI1(gene name)|psi-mi:ORAI1(display_short)|uniprotkb:CRACM1(gene name synonym)|uniprotkb:TMEM142A(gene name synonym)|uniprotkb:Protein orai-1(gene name synonym)|uniprotkb:Transmembrane protein 142A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Feng et al. (2010)	pubmed:20887894|imex:IM-15156	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2940153|imex:IM-15156-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006413(Calcium-transporting P-type ATPase, PMR1-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR030334|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|ensembl:ENSG00000064270(gene)|ensembl:ENST00000262429(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006828"(manganese ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015410"(ABC-type manganese transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0140613"(P-type manganese transporter activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|refseq:NP_055676.3|refseq:NP_001273456.2|refseq:NP_001278383.1	refseq:NP_116179.2|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR012446(Protein of unknown function DUF1650)|interpro:IPR038350|rcsb pdb:2MAK|rcsb pdb:4EHQ|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|ensembl:ENSG00000276045(gene)|ensembl:ENST00000617316(transcript)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070509"(calcium ion import)|dip:DIP-46289N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 6F|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/11/02	2018/09/18	rogid:9SWdgUO9aTf4/Bed+f8uYiEs+9I9606	rogid:VXcTrF/8sZA01XGUFZwvu75L7Kw9606	intact-crc:642CB880F8B8B4A1|rigid:hNXCBjImzEkxMDxuYdSH+PqEF+k	false	yellow fluorescent protein tag:?-?|sufficient binding region:1-106	glutathione s tranferase tag:?-?|sufficient binding region:1-91|sufficient binding region:255-301	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O75185	uniprotkb:Q96D31	intact:EBI-2939806|ensembl:ENSP00000262429|uniprotkb:B4DU76|uniprotkb:Q5S053|uniprotkb:Q68CQ2|uniprotkb:E7ES94|uniprotkb:Q5HYC3	intact:EBI-2291476|uniprotkb:Q3MHV3|uniprotkb:Q6DHX2|uniprotkb:Q96BP7|uniprotkb:Q96K71|ensembl:ENSP00000482568	psi-mi:at2c2_human(display_long)|uniprotkb:ATP2C2(gene name)|psi-mi:ATP2C2(display_short)|uniprotkb:KIAA0703(gene name synonym)|uniprotkb:SPCA2(gene name synonym)|uniprotkb:"Ca(2+)/Mn(2+)-ATPase 2C2"(gene name synonym)|uniprotkb:"Secretory pathway Ca(2+)-transporting ATPase type 2"(gene name synonym)	psi-mi:crcm1_human(display_long)|uniprotkb:ORAI1(gene name)|psi-mi:ORAI1(display_short)|uniprotkb:CRACM1(gene name synonym)|uniprotkb:TMEM142A(gene name synonym)|uniprotkb:Protein orai-1(gene name synonym)|uniprotkb:Transmembrane protein 142A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Feng et al. (2010)	pubmed:20887894|imex:IM-15156	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2940181|imex:IM-15156-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006413(Calcium-transporting P-type ATPase, PMR1-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR030334|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-936837|ensembl:ENSG00000064270(gene)|ensembl:ENST00000262429(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006828"(manganese ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015410"(ABC-type manganese transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0140613"(P-type manganese transporter activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|refseq:NP_055676.3|refseq:NP_001273456.2|refseq:NP_001278383.1	refseq:NP_116179.2|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR012446(Protein of unknown function DUF1650)|interpro:IPR038350|rcsb pdb:2MAK|rcsb pdb:4EHQ|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|ensembl:ENSG00000276045(gene)|ensembl:ENST00000617316(transcript)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070509"(calcium ion import)|dip:DIP-46289N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 7C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/11/02	2018/09/18	rogid:9SWdgUO9aTf4/Bed+f8uYiEs+9I9606	rogid:VXcTrF/8sZA01XGUFZwvu75L7Kw9606	intact-crc:1E942E149BD2BFD2|rigid:hNXCBjImzEkxMDxuYdSH+PqEF+k	false	glutathione s tranferase tag:?-?|sufficient binding region:870-946	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)