#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8K4J6	uniprotkb:O00629	intact:EBI-8291665|intact:UNK-5521183|uniprotkb:Q642U1|ensembl:ENSMUSP00000105207	intact:EBI-396343|uniprotkb:O00190|intact:EBI-28976443|ensembl:ENSP00000334373|uniprotkb:A8K4S6|uniprotkb:D3DNM2	psi-mi:mrtfa_mouse(display_long)|uniprotkb:Mrtfa(gene name)|psi-mi:Mrtfa(display_short)|uniprotkb:Basic SAP coiled-coil transcription activator(gene name synonym)|uniprotkb:Bsac(gene name synonym)|uniprotkb:MKL/myocardin-like protein 1(gene name synonym)|uniprotkb:Mal(gene name synonym)|uniprotkb:Megakaryoblastic leukemia 1 protein homolog(gene name synonym)|uniprotkb:Megakaryocytic acute leukemia protein homolog(gene name synonym)|uniprotkb:Mkl1(gene name synonym)	psi-mi:ima3_human(display_long)|uniprotkb:KPNA4(gene name)|psi-mi:KPNA4(display_short)|uniprotkb:QIP1(gene name synonym)|uniprotkb:Karyopherin subunit alpha-4(gene name synonym)|uniprotkb:Importin alpha Q1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pawłowski et al. (2010)	pubmed:20818336|imex:IM-15295|mint:MINT-8078499|doi:10.1038/emboj.2010.216	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8291659|mint:MINT-8078507|imex:IM-15295-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001076005.1|refseq:NP_694629.2|dip:DIP-60884N|ensembl:ENSMUSG00000042292(gene)|ensembl:ENSMUST00000109579(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001764"(neuron migration)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010735"(positive regulation of transcription via serum response element binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004018(RPEL repeat)|interpro:IPR029992|interpro:IPR036361|interpro:IPR043451|mint:Q8K4J6|rcsb pdb:2V51|rcsb pdb:2V52|rcsb pdb:2YJE|rcsb pdb:2YJF|reactome:R-MMU-3899300|reactome:R-MMU-5663220|go:"GO:0005829"(cytosol)|mint:MINT-8078511(identity)	refseq:NP_002259.1|ensembl:ENSG00000186432(gene)|ensembl:ENST00000334256(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:O00629|rcsb pdb:4UAE|rcsb pdb:5TBK|rcsb pdb:5XZX|rcsb pdb:6BVV|rcsb pdb:6BVZ|rcsb pdb:6BW9|rcsb pdb:6BWA|rcsb pdb:6BWB|rcsb pdb:6WX8|rcsb pdb:7JJL|reactome:R-HSA-1169408|reactome:R-HSA-168276|ensembl:ENSP00000334373|dip:DIP-32982N|mint:MINT-8078509(identity)	-	comment:mint|function:"Transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation"	-	figure legend:f5a, 6B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/12/09	2017/03/03	rogid:JllEBRX54Z25+MAvSfRzjCaaQ5810090	rogid:/cng/xZ42E2juzHNOpuQTP+amx89606	intact-crc:A2A26DA89B38B0CC|rigid:eze2uVOLXXSabWBpqrKFAxfAOOY	false	mutation decreasing interaction strength:62-64(MINT-8078526)|mutation decreasing interaction strength:95-97(MINT-8078520)|glutathione s tranferase tag:n-n(MINT-8078517)|mutation disrupting interaction strength:62-64,95-97(MINT-8078523)|binding-associated region:2-146(MINT-8078766)|green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:O00629	uniprotkb:Q8K4J6	intact:EBI-396343|uniprotkb:O00190|intact:EBI-28976443|ensembl:ENSP00000334373|uniprotkb:A8K4S6|uniprotkb:D3DNM2	intact:EBI-8291665|intact:UNK-5521183|uniprotkb:Q642U1|ensembl:ENSMUSP00000105207	psi-mi:ima3_human(display_long)|uniprotkb:KPNA4(gene name)|psi-mi:KPNA4(display_short)|uniprotkb:QIP1(gene name synonym)|uniprotkb:Karyopherin subunit alpha-4(gene name synonym)|uniprotkb:Importin alpha Q1(gene name synonym)	psi-mi:mrtfa_mouse(display_long)|uniprotkb:Mrtfa(gene name)|psi-mi:Mrtfa(display_short)|uniprotkb:Basic SAP coiled-coil transcription activator(gene name synonym)|uniprotkb:Bsac(gene name synonym)|uniprotkb:MKL/myocardin-like protein 1(gene name synonym)|uniprotkb:Mal(gene name synonym)|uniprotkb:Megakaryoblastic leukemia 1 protein homolog(gene name synonym)|uniprotkb:Megakaryocytic acute leukemia protein homolog(gene name synonym)|uniprotkb:Mkl1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pawłowski et al. (2010)	pubmed:20818336|imex:IM-15295|mint:MINT-8078499|doi:10.1038/emboj.2010.216	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8291902|mint:MINT-8078602|imex:IM-15295-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002259.1|ensembl:ENSG00000186432(gene)|ensembl:ENST00000334256(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:O00629|rcsb pdb:4UAE|rcsb pdb:5TBK|rcsb pdb:5XZX|rcsb pdb:6BVV|rcsb pdb:6BVZ|rcsb pdb:6BW9|rcsb pdb:6BWA|rcsb pdb:6BWB|rcsb pdb:6WX8|rcsb pdb:7JJL|reactome:R-HSA-1169408|reactome:R-HSA-168276|ensembl:ENSP00000334373|dip:DIP-32982N|mint:MINT-8078604(identity)	refseq:NP_001076005.1|refseq:NP_694629.2|dip:DIP-60884N|ensembl:ENSMUSG00000042292(gene)|ensembl:ENSMUST00000109579(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001764"(neuron migration)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010735"(positive regulation of transcription via serum response element binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004018(RPEL repeat)|interpro:IPR029992|interpro:IPR036361|interpro:IPR043451|mint:Q8K4J6|rcsb pdb:2V51|rcsb pdb:2V52|rcsb pdb:2YJE|rcsb pdb:2YJF|reactome:R-MMU-3899300|reactome:R-MMU-5663220|go:"GO:0005829"(cytosol)|mint:MINT-8078610(identity)	-	-	comment:mint|function:"Transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation"	figure legend:f5b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/12/09	2017/03/03	rogid:/cng/xZ42E2juzHNOpuQTP+amx89606	rogid:JllEBRX54Z25+MAvSfRzjCaaQ5810090	intact-crc:A62A6EA3A04B54AF|rigid:eub5JXWE0N1m22g2sjlhyD7HQoA	false	glutathione s tranferase tag:?-?(MINT-8078605)	mutation decreasing interaction strength:62-64(MINT-8078613)|mutation decreasing interaction strength:95-97(MINT-8078617)|green fluorescent protein tag:?-?(MINT-8078611)|binding-associated region:2-146(MINT-8078778)|mutation disrupting interaction strength:95-97,62-64(MINT-8078615)	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:O00629	uniprotkb:Q14974	intact:EBI-396343|uniprotkb:O00190|intact:EBI-28976443|ensembl:ENSP00000334373|uniprotkb:A8K4S6|uniprotkb:D3DNM2	intact:EBI-286758|uniprotkb:Q14637|uniprotkb:Q96J27|uniprotkb:Q53XN2|uniprotkb:B7ZAV6|uniprotkb:D3DTT3|intact:EBI-28976864|ensembl:ENSP00000290158|ensembl:ENSP00000464042	psi-mi:ima3_human(display_long)|uniprotkb:KPNA4(gene name)|psi-mi:KPNA4(display_short)|uniprotkb:QIP1(gene name synonym)|uniprotkb:Karyopherin subunit alpha-4(gene name synonym)|uniprotkb:Importin alpha Q1(gene name synonym)	psi-mi:imb1_human(display_long)|uniprotkb:Karyopherin subunit beta-1(gene name synonym)|uniprotkb:Nuclear factor p97(gene name synonym)|uniprotkb:Importin-90(gene name synonym)|uniprotkb:KPNB1(gene name)|psi-mi:KPNB1(display_short)|uniprotkb:NTF97(gene name synonym)|uniprotkb:Pore targeting complex 97 kDa subunit(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pawłowski et al. (2010)	pubmed:20818336|imex:IM-15295|mint:MINT-8078499|doi:10.1038/emboj.2010.216	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8291902|mint:MINT-8078602|imex:IM-15295-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002259.1|ensembl:ENSG00000186432(gene)|ensembl:ENST00000334256(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:O00629|rcsb pdb:4UAE|rcsb pdb:5TBK|rcsb pdb:5XZX|rcsb pdb:6BVV|rcsb pdb:6BVZ|rcsb pdb:6BW9|rcsb pdb:6BWA|rcsb pdb:6BWB|rcsb pdb:6WX8|rcsb pdb:7JJL|reactome:R-HSA-1169408|reactome:R-HSA-168276|ensembl:ENSP00000334373|dip:DIP-32982N|mint:MINT-8078604(identity)	ensembl:ENSP00000290158|ensembl:ENST00000535458|ensembl:ENSP00000438253|ensembl:ENST00000540627|ensembl:ENSP00000438964|ensembl:ENSP00000464042|refseq:NP_002256.2|refseq:NP_001263382.1|dip:DIP-6204N|ensembl:ENSG00000108424(gene)|ensembl:ENST00000290158(transcript)|ensembl:ENST00000583648(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031291"(Ran protein signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000225(Armadillo)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR040122|mint:Q14974|rcsb pdb:1F59|rcsb pdb:1IBR|rcsb pdb:1M5N|rcsb pdb:1O6O|rcsb pdb:1O6P|rcsb pdb:1QGK|rcsb pdb:1QGR|rcsb pdb:2P8Q|rcsb pdb:2Q5D|rcsb pdb:2QNA|rcsb pdb:3LWW|rcsb pdb:3W5K|rcsb pdb:6N88|rcsb pdb:6N89|reactome:R-HSA-1169408|reactome:R-HSA-140342|reactome:R-HSA-1655829|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-180746|reactome:R-HSA-2995383|reactome:R-HSA-6798695|reactome:R-HSA-909733|reactome:R-HSA-9615933|reactome:R-HSA-9636249|mint:MINT-8078608(identity)	-	-	-	figure legend:f5b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/12/09	2017/03/03	rogid:/cng/xZ42E2juzHNOpuQTP+amx89606	rogid:8NbS9qoyCx+M+X3KOe1+PQ3oSYk9606	intact-crc:A62A6EA3A04B54AF|rigid:eub5JXWE0N1m22g2sjlhyD7HQoA	false	glutathione s tranferase tag:?-?(MINT-8078605)	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q8K4J6	uniprotkb:O00629	intact:EBI-8291665|intact:UNK-5521183|uniprotkb:Q642U1|ensembl:ENSMUSP00000105207	intact:EBI-396343|uniprotkb:O00190|intact:EBI-28976443|ensembl:ENSP00000334373|uniprotkb:A8K4S6|uniprotkb:D3DNM2	psi-mi:mrtfa_mouse(display_long)|uniprotkb:Mrtfa(gene name)|psi-mi:Mrtfa(display_short)|uniprotkb:Basic SAP coiled-coil transcription activator(gene name synonym)|uniprotkb:Bsac(gene name synonym)|uniprotkb:MKL/myocardin-like protein 1(gene name synonym)|uniprotkb:Mal(gene name synonym)|uniprotkb:Megakaryoblastic leukemia 1 protein homolog(gene name synonym)|uniprotkb:Megakaryocytic acute leukemia protein homolog(gene name synonym)|uniprotkb:Mkl1(gene name synonym)	psi-mi:ima3_human(display_long)|uniprotkb:KPNA4(gene name)|psi-mi:KPNA4(display_short)|uniprotkb:QIP1(gene name synonym)|uniprotkb:Karyopherin subunit alpha-4(gene name synonym)|uniprotkb:Importin alpha Q1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pawłowski et al. (2010)	pubmed:20818336|imex:IM-15295|mint:MINT-8078499|doi:10.1038/emboj.2010.216	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8291938|mint:MINT-8078624|imex:IM-15295-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001076005.1|refseq:NP_694629.2|dip:DIP-60884N|ensembl:ENSMUSG00000042292(gene)|ensembl:ENSMUST00000109579(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001764"(neuron migration)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010735"(positive regulation of transcription via serum response element binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004018(RPEL repeat)|interpro:IPR029992|interpro:IPR036361|interpro:IPR043451|mint:Q8K4J6|rcsb pdb:2V51|rcsb pdb:2V52|rcsb pdb:2YJE|rcsb pdb:2YJF|reactome:R-MMU-3899300|reactome:R-MMU-5663220|go:"GO:0005829"(cytosol)|mint:MINT-8078632(identity)	refseq:NP_002259.1|ensembl:ENSG00000186432(gene)|ensembl:ENST00000334256(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:O00629|rcsb pdb:4UAE|rcsb pdb:5TBK|rcsb pdb:5XZX|rcsb pdb:6BVV|rcsb pdb:6BVZ|rcsb pdb:6BW9|rcsb pdb:6BWA|rcsb pdb:6BWB|rcsb pdb:6WX8|rcsb pdb:7JJL|reactome:R-HSA-1169408|reactome:R-HSA-168276|ensembl:ENSP00000334373|dip:DIP-32982N|mint:MINT-8078626(identity)	-	comment:mint|function:"Transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation"	-	figure legend:f5c|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/12/09	2017/03/03	rogid:JllEBRX54Z25+MAvSfRzjCaaQ5810090	rogid:/cng/xZ42E2juzHNOpuQTP+amx89606	intact-crc:5F965124DEF2005E|rigid:eze2uVOLXXSabWBpqrKFAxfAOOY	false	green fluorescent protein tag:?-?(MINT-8078633)	mutation decreasing interaction strength:183-183,179-179(MINT-8078645)|glutathione s tranferase tag:?-?(MINT-8078627)|mutation decreasing interaction strength:394-394,390-390(MINT-8078648)|necessary binding region:2-58(IPR002652)|mutation decreasing interaction strength:179-179,183-183,390-390,394-394	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q8K4J6	uniprotkb:Q14974	intact:EBI-8291665|intact:UNK-5521183|uniprotkb:Q642U1|ensembl:ENSMUSP00000105207	intact:EBI-286758|uniprotkb:Q14637|uniprotkb:Q96J27|uniprotkb:Q53XN2|uniprotkb:B7ZAV6|uniprotkb:D3DTT3|intact:EBI-28976864|ensembl:ENSP00000290158|ensembl:ENSP00000464042	psi-mi:mrtfa_mouse(display_long)|uniprotkb:Mrtfa(gene name)|psi-mi:Mrtfa(display_short)|uniprotkb:Basic SAP coiled-coil transcription activator(gene name synonym)|uniprotkb:Bsac(gene name synonym)|uniprotkb:MKL/myocardin-like protein 1(gene name synonym)|uniprotkb:Mal(gene name synonym)|uniprotkb:Megakaryoblastic leukemia 1 protein homolog(gene name synonym)|uniprotkb:Megakaryocytic acute leukemia protein homolog(gene name synonym)|uniprotkb:Mkl1(gene name synonym)	psi-mi:imb1_human(display_long)|uniprotkb:Karyopherin subunit beta-1(gene name synonym)|uniprotkb:Nuclear factor p97(gene name synonym)|uniprotkb:Importin-90(gene name synonym)|uniprotkb:KPNB1(gene name)|psi-mi:KPNB1(display_short)|uniprotkb:NTF97(gene name synonym)|uniprotkb:Pore targeting complex 97 kDa subunit(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pawłowski et al. (2010)	pubmed:20818336|imex:IM-15295|mint:MINT-8078499|doi:10.1038/emboj.2010.216	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8292094|mint:MINT-8078719|imex:IM-15295-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001076005.1|refseq:NP_694629.2|dip:DIP-60884N|ensembl:ENSMUSG00000042292(gene)|ensembl:ENSMUST00000109579(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001764"(neuron migration)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010735"(positive regulation of transcription via serum response element binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004018(RPEL repeat)|interpro:IPR029992|interpro:IPR036361|interpro:IPR043451|mint:Q8K4J6|rcsb pdb:2V51|rcsb pdb:2V52|rcsb pdb:2YJE|rcsb pdb:2YJF|reactome:R-MMU-3899300|reactome:R-MMU-5663220|go:"GO:0005829"(cytosol)|mint:MINT-8078725(identity)	ensembl:ENSP00000290158|ensembl:ENST00000535458|ensembl:ENSP00000438253|ensembl:ENST00000540627|ensembl:ENSP00000438964|ensembl:ENSP00000464042|refseq:NP_002256.2|refseq:NP_001263382.1|dip:DIP-6204N|ensembl:ENSG00000108424(gene)|ensembl:ENST00000290158(transcript)|ensembl:ENST00000583648(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031291"(Ran protein signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000225(Armadillo)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR040122|mint:Q14974|rcsb pdb:1F59|rcsb pdb:1IBR|rcsb pdb:1M5N|rcsb pdb:1O6O|rcsb pdb:1O6P|rcsb pdb:1QGK|rcsb pdb:1QGR|rcsb pdb:2P8Q|rcsb pdb:2Q5D|rcsb pdb:2QNA|rcsb pdb:3LWW|rcsb pdb:3W5K|rcsb pdb:6N88|rcsb pdb:6N89|reactome:R-HSA-1169408|reactome:R-HSA-140342|reactome:R-HSA-1655829|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-180746|reactome:R-HSA-2995383|reactome:R-HSA-6798695|reactome:R-HSA-909733|reactome:R-HSA-9615933|reactome:R-HSA-9636249|mint:MINT-8078723(identity)	-	comment:mint|function:"Transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation"	-	figure legend:f5d|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/12/09	2017/03/03	rogid:JllEBRX54Z25+MAvSfRzjCaaQ5810090	rogid:8NbS9qoyCx+M+X3KOe1+PQ3oSYk9606	intact-crc:E028B26816651B4F|rigid:bjYuWExtvRaH+Mfsy6oaPDXYUuk	false	mutation decreasing interaction strength:62-64(MINT-8078730)|binding-associated region:2-204(MINT-8078781)|glutathione s tranferase tag:n-n(MINT-8078726)|mutation disrupting interaction strength:95-97(MINT-8078728)|green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:O00629	uniprotkb:Q14974	intact:EBI-396343|uniprotkb:O00190|intact:EBI-28976443|ensembl:ENSP00000334373|uniprotkb:A8K4S6|uniprotkb:D3DNM2	intact:EBI-286758|uniprotkb:Q14637|uniprotkb:Q96J27|uniprotkb:Q53XN2|uniprotkb:B7ZAV6|uniprotkb:D3DTT3|intact:EBI-28976864|ensembl:ENSP00000290158|ensembl:ENSP00000464042	psi-mi:ima3_human(display_long)|uniprotkb:KPNA4(gene name)|psi-mi:KPNA4(display_short)|uniprotkb:QIP1(gene name synonym)|uniprotkb:Karyopherin subunit alpha-4(gene name synonym)|uniprotkb:Importin alpha Q1(gene name synonym)	psi-mi:imb1_human(display_long)|uniprotkb:Karyopherin subunit beta-1(gene name synonym)|uniprotkb:Nuclear factor p97(gene name synonym)|uniprotkb:Importin-90(gene name synonym)|uniprotkb:KPNB1(gene name)|psi-mi:KPNB1(display_short)|uniprotkb:NTF97(gene name synonym)|uniprotkb:Pore targeting complex 97 kDa subunit(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pawłowski et al. (2010)	pubmed:20818336|imex:IM-15295|mint:MINT-8078499|doi:10.1038/emboj.2010.216	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-13941637|imex:IM-15295-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002259.1|ensembl:ENSG00000186432(gene)|ensembl:ENST00000334256(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:O00629|rcsb pdb:4UAE|rcsb pdb:5TBK|rcsb pdb:5XZX|rcsb pdb:6BVV|rcsb pdb:6BVZ|rcsb pdb:6BW9|rcsb pdb:6BWA|rcsb pdb:6BWB|rcsb pdb:6WX8|rcsb pdb:7JJL|reactome:R-HSA-1169408|reactome:R-HSA-168276|ensembl:ENSP00000334373|dip:DIP-32982N|mint:MINT-8078583(identity)	ensembl:ENSP00000290158|ensembl:ENST00000535458|ensembl:ENSP00000438253|ensembl:ENST00000540627|ensembl:ENSP00000438964|ensembl:ENSP00000464042|refseq:NP_002256.2|refseq:NP_001263382.1|dip:DIP-6204N|ensembl:ENSG00000108424(gene)|ensembl:ENST00000290158(transcript)|ensembl:ENST00000583648(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031291"(Ran protein signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000225(Armadillo)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR040122|mint:Q14974|rcsb pdb:1F59|rcsb pdb:1IBR|rcsb pdb:1M5N|rcsb pdb:1O6O|rcsb pdb:1O6P|rcsb pdb:1QGK|rcsb pdb:1QGR|rcsb pdb:2P8Q|rcsb pdb:2Q5D|rcsb pdb:2QNA|rcsb pdb:3LWW|rcsb pdb:3W5K|rcsb pdb:6N88|rcsb pdb:6N89|reactome:R-HSA-1169408|reactome:R-HSA-140342|reactome:R-HSA-1655829|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-180746|reactome:R-HSA-2995383|reactome:R-HSA-6798695|reactome:R-HSA-909733|reactome:R-HSA-9615933|reactome:R-HSA-9636249|mint:MINT-8078585(identity)	-	-	-	figure legend:f5b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/12/09	2017/03/03	rogid:/cng/xZ42E2juzHNOpuQTP+amx89606	rogid:8NbS9qoyCx+M+X3KOe1+PQ3oSYk9606	rigid:9OkAFphTtq/2I/fh5/UMQLmNgNQ	false	glutathione s tranferase tag:?-?(MINT-8078598)	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q8K4J6	uniprotkb:Q14974	intact:EBI-8291665|intact:UNK-5521183|uniprotkb:Q642U1|ensembl:ENSMUSP00000105207	intact:EBI-286758|uniprotkb:Q14637|uniprotkb:Q96J27|uniprotkb:Q53XN2|uniprotkb:B7ZAV6|uniprotkb:D3DTT3|intact:EBI-28976864|ensembl:ENSP00000290158|ensembl:ENSP00000464042	psi-mi:mrtfa_mouse(display_long)|uniprotkb:Mrtfa(gene name)|psi-mi:Mrtfa(display_short)|uniprotkb:Basic SAP coiled-coil transcription activator(gene name synonym)|uniprotkb:Bsac(gene name synonym)|uniprotkb:MKL/myocardin-like protein 1(gene name synonym)|uniprotkb:Mal(gene name synonym)|uniprotkb:Megakaryoblastic leukemia 1 protein homolog(gene name synonym)|uniprotkb:Megakaryocytic acute leukemia protein homolog(gene name synonym)|uniprotkb:Mkl1(gene name synonym)	psi-mi:imb1_human(display_long)|uniprotkb:Karyopherin subunit beta-1(gene name synonym)|uniprotkb:Nuclear factor p97(gene name synonym)|uniprotkb:Importin-90(gene name synonym)|uniprotkb:KPNB1(gene name)|psi-mi:KPNB1(display_short)|uniprotkb:NTF97(gene name synonym)|uniprotkb:Pore targeting complex 97 kDa subunit(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pawłowski et al. (2010)	pubmed:20818336|imex:IM-15295|mint:MINT-8078499|doi:10.1038/emboj.2010.216	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-13941930|imex:IM-15295-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001076005.1|refseq:NP_694629.2|dip:DIP-60884N|ensembl:ENSMUSG00000042292(gene)|ensembl:ENSMUST00000109579(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001764"(neuron migration)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010735"(positive regulation of transcription via serum response element binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004018(RPEL repeat)|interpro:IPR029992|interpro:IPR036361|interpro:IPR043451|mint:Q8K4J6|rcsb pdb:2V51|rcsb pdb:2V52|rcsb pdb:2YJE|rcsb pdb:2YJF|reactome:R-MMU-3899300|reactome:R-MMU-5663220|go:"GO:0005829"(cytosol)|mint:MINT-8078511(identity)	ensembl:ENSP00000290158|ensembl:ENST00000535458|ensembl:ENSP00000438253|ensembl:ENST00000540627|ensembl:ENSP00000438964|ensembl:ENSP00000464042|refseq:NP_002256.2|refseq:NP_001263382.1|dip:DIP-6204N|ensembl:ENSG00000108424(gene)|ensembl:ENST00000290158(transcript)|ensembl:ENST00000583648(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031291"(Ran protein signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000225(Armadillo)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR040122|mint:Q14974|rcsb pdb:1F59|rcsb pdb:1IBR|rcsb pdb:1M5N|rcsb pdb:1O6O|rcsb pdb:1O6P|rcsb pdb:1QGK|rcsb pdb:1QGR|rcsb pdb:2P8Q|rcsb pdb:2Q5D|rcsb pdb:2QNA|rcsb pdb:3LWW|rcsb pdb:3W5K|rcsb pdb:6N88|rcsb pdb:6N89|reactome:R-HSA-1169408|reactome:R-HSA-140342|reactome:R-HSA-1655829|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-180746|reactome:R-HSA-2995383|reactome:R-HSA-6798695|reactome:R-HSA-909733|reactome:R-HSA-9615933|reactome:R-HSA-9636249	-	comment:mint|function:"Transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation"	-	figure legend:f6a|comment:Interaction was disrupted by increasing amounts of actin.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/12/09	2017/03/03	rogid:JllEBRX54Z25+MAvSfRzjCaaQ5810090	rogid:8NbS9qoyCx+M+X3KOe1+PQ3oSYk9606	rigid:eub5JXWE0N1m22g2sjlhyD7HQoA	false	glutathione s tranferase tag:n-n(MINT-8078517)|binding-associated region:2-146(MINT-8078766)|green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q8K4J6	uniprotkb:O00629	intact:EBI-8291665|intact:UNK-5521183|uniprotkb:Q642U1|ensembl:ENSMUSP00000105207	intact:EBI-396343|uniprotkb:O00190|intact:EBI-28976443|ensembl:ENSP00000334373|uniprotkb:A8K4S6|uniprotkb:D3DNM2	psi-mi:mrtfa_mouse(display_long)|uniprotkb:Mrtfa(gene name)|psi-mi:Mrtfa(display_short)|uniprotkb:Basic SAP coiled-coil transcription activator(gene name synonym)|uniprotkb:Bsac(gene name synonym)|uniprotkb:MKL/myocardin-like protein 1(gene name synonym)|uniprotkb:Mal(gene name synonym)|uniprotkb:Megakaryoblastic leukemia 1 protein homolog(gene name synonym)|uniprotkb:Megakaryocytic acute leukemia protein homolog(gene name synonym)|uniprotkb:Mkl1(gene name synonym)	psi-mi:ima3_human(display_long)|uniprotkb:KPNA4(gene name)|psi-mi:KPNA4(display_short)|uniprotkb:QIP1(gene name synonym)|uniprotkb:Karyopherin subunit alpha-4(gene name synonym)|uniprotkb:Importin alpha Q1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pawłowski et al. (2010)	pubmed:20818336|imex:IM-15295|mint:MINT-8078499|doi:10.1038/emboj.2010.216	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-13941930|imex:IM-15295-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001076005.1|refseq:NP_694629.2|dip:DIP-60884N|ensembl:ENSMUSG00000042292(gene)|ensembl:ENSMUST00000109579(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001764"(neuron migration)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010735"(positive regulation of transcription via serum response element binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004018(RPEL repeat)|interpro:IPR029992|interpro:IPR036361|interpro:IPR043451|mint:Q8K4J6|rcsb pdb:2V51|rcsb pdb:2V52|rcsb pdb:2YJE|rcsb pdb:2YJF|reactome:R-MMU-3899300|reactome:R-MMU-5663220|go:"GO:0005829"(cytosol)|mint:MINT-8078511(identity)	refseq:NP_002259.1|ensembl:ENSG00000186432(gene)|ensembl:ENST00000334256(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:O00629|rcsb pdb:4UAE|rcsb pdb:5TBK|rcsb pdb:5XZX|rcsb pdb:6BVV|rcsb pdb:6BVZ|rcsb pdb:6BW9|rcsb pdb:6BWA|rcsb pdb:6BWB|rcsb pdb:6WX8|rcsb pdb:7JJL|reactome:R-HSA-1169408|reactome:R-HSA-168276|ensembl:ENSP00000334373|dip:DIP-32982N|mint:MINT-8078509(identity)	-	comment:mint|function:"Transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation"	-	figure legend:f6a|comment:Interaction was disrupted by increasing amounts of actin.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/12/09	2017/03/03	rogid:JllEBRX54Z25+MAvSfRzjCaaQ5810090	rogid:/cng/xZ42E2juzHNOpuQTP+amx89606	rigid:eub5JXWE0N1m22g2sjlhyD7HQoA	false	glutathione s tranferase tag:n-n(MINT-8078517)|binding-associated region:2-146(MINT-8078766)|green fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q969V6	uniprotkb:O00505	intact:EBI-493122|uniprotkb:Q8TCL1|uniprotkb:Q96SC5|uniprotkb:Q96SC6|uniprotkb:Q9P2B0|intact:EBI-28979024|ensembl:ENSP00000385835	intact:EBI-358297|intact:EBI-28976892|ensembl:ENSP00000261667|uniprotkb:O00191|uniprotkb:O43195|uniprotkb:Q96AA7|uniprotkb:Q5JVM9|intact:EBI-742146|uniprotkb:Q8IYQ9	psi-mi:mrtfa_human(display_long)|uniprotkb:MRTFA(gene name)|psi-mi:MRTFA(display_short)|uniprotkb:KIAA1438(gene name synonym)|uniprotkb:MAL(gene name synonym)|uniprotkb:MKL/myocardin-like protein 1(gene name synonym)|uniprotkb:MKL1(gene name synonym)|uniprotkb:Megakaryoblastic leukemia 1 protein(gene name synonym)|uniprotkb:Megakaryocytic acute leukemia protein(gene name synonym)	psi-mi:ima4_human(display_long)|uniprotkb:KPNA3(gene name)|psi-mi:KPNA3(display_short)|uniprotkb:QIP2(gene name synonym)|uniprotkb:Karyopherin subunit alpha-3(gene name synonym)|uniprotkb:SRP1-gamma(gene name synonym)|uniprotkb:Importin alpha Q2(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Pawłowski et al. (2010)	pubmed:20818336|imex:IM-15295|mint:MINT-8078499|doi:10.1038/emboj.2010.216	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8292157|mint:MINT-8078739|imex:IM-15295-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269589.1|refseq:NP_001269590.1|refseq:NP_065882.1|ensembl:ENSP00000385835|refseq:XP_005261751.1|ensembl:ENSG00000196588(gene)|ensembl:ENST00000407029(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010735"(positive regulation of transcription via serum response element binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051145"(smooth muscle cell differentiation)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004018(RPEL repeat)|interpro:IPR029992|interpro:IPR036361|interpro:IPR043451|rcsb pdb:2KVU|rcsb pdb:2KW9|reactome:R-HSA-3899300|reactome:R-HSA-5663220|mint:MINT-8078743(identity)	ensembl:ENSG00000102753(gene)|ensembl:ENST00000261667(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0043657"(host cell)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000225(Armadillo)|refseq:NP_002258.2|ensembl:ENSP00000261667|dip:DIP-27586N|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:O00505|reactome:R-HSA-1169408|reactome:R-HSA-168276|mint:MINT-8078741(identity)	-	-	-	figure legend:Supp Fig 2|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/12/09	2017/03/03	rogid:m9kdYm+MiCAqHa/IUa44qp33h9U9606	rogid:kx/oTYWMYG7dhwJHvr1POLD6FTU9606	intact-crc:9BE98060BF9BE970|rigid:4XDK3frhmZ+yPsQbZwRChbFC3qo	false	sufficient binding region:52-81(MINT-8078758)|tandem tag:?-?(MINT-8078750)	glutathione s tranferase tag:?-?(MINT-8089118)	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)