#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9V393	uniprotkb:P40417	intact:EBI-100228|ensemblmetazoa:FBpp0085236|ensemblmetazoa:FBpp0293792	intact:EBI-867790|uniprotkb:A0A021WW06|uniprotkb:Q7PL59|uniprotkb:Q9W5M2|uniprotkb:A8Y4W1|uniprotkb:A8Y4W2|uniprotkb:Q9W5M3|ensemblmetazoa:FBpp0112423|ensemblmetazoa:FBpp0112425|ensemblmetazoa:FBpp0112426|ensemblmetazoa:FBpp0311493	psi-mi:q9v393_drome(display_long)|uniprotkb:krz(gene name)|psi-mi:krz(display_short)|uniprotkb:CG1487(orf name)|uniprotkb:0952(gene name synonym)|uniprotkb:14(gene name synonym)|uniprotkb:Dmel\CG1487(gene name synonym)|uniprotkb:Krz(gene name synonym)|uniprotkb:Kurz(gene name synonym)|uniprotkb:"l(3)S095214"(gene name synonym)|uniprotkb:Dmel_CG1487(orf name)|uniprotkb:beta-arr2(gene name synonym)	psi-mi:erka_drome(display_long)|uniprotkb:Extracellular-regulated kinase A(gene name synonym)|uniprotkb:Protein rolled(gene name synonym)|uniprotkb:rl(gene name)|psi-mi:rl(display_short)|uniprotkb:ERKa(gene name synonym)|uniprotkb:CG12559(orf name)|uniprotkb:MAPK(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tipping et al. (2010)	pubmed:20802461|imex:IM-15196|mint:MINT-8075200|doi:10.1038/emboj.2010.202	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8179397|mint:MINT-8075208|imex:IM-15196-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524988.1|flybase:FBgn0040206|refseq:NP_001247400.1|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|reactome:R-DME-432720|reactome:R-DME-432722|reactome:R-DME-456926|reactome:R-DME-5099900|reactome:R-DME-5674135|reactome:R-DME-8856825|reactome:R-DME-8856828|ensemblmetazoa:FBgn0040206(gene)|ensemblmetazoa:FBtr0085877(transcript)|ensemblmetazoa:FBtr0305268(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0031648"(protein destabilization)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060189"(positive regulation of protein desumoylation)|go:"GO:0120177"(negative regulation of torso signaling pathway)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|mint:MINT-8075210(identity)	refseq:NP_001015121.3|refseq:NP_001104348.2|refseq:NP_001287635.1|refseq:NP_001015122.1|refseq:NP_001015123.1|refseq:NP_001104349.1|flybase:FBgn0003256|dip:DIP-17266N|ensemblmetazoa:FBgn0003256(gene)|ensemblmetazoa:FBtr0113700(transcript)|ensemblmetazoa:FBtr0113702(transcript)|ensemblmetazoa:FBtr0113703(transcript)|ensemblmetazoa:FBtr0345337(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007362"(terminal region determination)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007479"(leg disc proximal/distal pattern formation)|go:"GO:0007552"(metamorphosis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035169"(lymph gland plasmatocyte differentiation)|go:"GO:0035170"(lymph gland crystal cell differentiation)|go:"GO:0035202"(tracheal pit formation in open tracheal system)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046534"(positive regulation of photoreceptor cell differentiation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000826"(regulation of heart morphogenesis)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P40417|reactome:R-DME-110056|reactome:R-DME-112409|reactome:R-DME-112411|reactome:R-DME-1295596|reactome:R-DME-162658|reactome:R-DME-170968|reactome:R-DME-198753|reactome:R-DME-202670|reactome:R-DME-2029482|reactome:R-DME-2559580|reactome:R-DME-2559582|reactome:R-DME-2559585|reactome:R-DME-2871796|reactome:R-DME-3371453|reactome:R-DME-375165|reactome:R-DME-437239|reactome:R-DME-445144|reactome:R-DME-450341|reactome:R-DME-456926|reactome:R-DME-5654726|reactome:R-DME-5654727|reactome:R-DME-5654732|reactome:R-DME-5654733|reactome:R-DME-5663213|reactome:R-DME-5673001|reactome:R-DME-5674135|reactome:R-DME-5674499|reactome:R-DME-5675221|reactome:R-DME-5687128|reactome:R-DME-6798695|reactome:R-DME-74749|reactome:R-DME-881907|reactome:R-DME-9634635|reactome:R-DME-9634638|mint:MINT-8075211(identity)	-	-	-	figure legend:f4a|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2010/11/26	2014/10/16	rogid:u4kgjQVpafnDKhPINoD7ftUYmNo7227	rogid:m7w7KhuZSyx3t+dR2TKtvx/vRtA7227	intact-crc:3829C7342B14E6B1|rigid:P0vKsKAmH2zoNQ06UZj7BYKQqFk	false	mutation decreasing interaction:336-336(MINT-8075221)|ha tag:?-?(MINT-8075213)	flag tag:?-?(MINT-8075217)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P40417	uniprotkb:Q9V393	intact:EBI-867790|uniprotkb:A0A021WW06|uniprotkb:Q7PL59|uniprotkb:Q9W5M2|uniprotkb:A8Y4W1|uniprotkb:A8Y4W2|uniprotkb:Q9W5M3|ensemblmetazoa:FBpp0112423|ensemblmetazoa:FBpp0112425|ensemblmetazoa:FBpp0112426|ensemblmetazoa:FBpp0311493	intact:EBI-100228|ensemblmetazoa:FBpp0085236|ensemblmetazoa:FBpp0293792	psi-mi:erka_drome(display_long)|uniprotkb:Extracellular-regulated kinase A(gene name synonym)|uniprotkb:Protein rolled(gene name synonym)|uniprotkb:rl(gene name)|psi-mi:rl(display_short)|uniprotkb:ERKa(gene name synonym)|uniprotkb:CG12559(orf name)|uniprotkb:MAPK(gene name synonym)	psi-mi:q9v393_drome(display_long)|uniprotkb:krz(gene name)|psi-mi:krz(display_short)|uniprotkb:CG1487(orf name)|uniprotkb:0952(gene name synonym)|uniprotkb:14(gene name synonym)|uniprotkb:Dmel\CG1487(gene name synonym)|uniprotkb:Krz(gene name synonym)|uniprotkb:Kurz(gene name synonym)|uniprotkb:"l(3)S095214"(gene name synonym)|uniprotkb:Dmel_CG1487(orf name)|uniprotkb:beta-arr2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tipping et al. (2010)	pubmed:20802461|imex:IM-15196|mint:MINT-8075200|doi:10.1038/emboj.2010.202	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8179418|mint:MINT-8075225|imex:IM-15196-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001015121.3|refseq:NP_001104348.2|refseq:NP_001287635.1|refseq:NP_001015122.1|refseq:NP_001015123.1|refseq:NP_001104349.1|flybase:FBgn0003256|dip:DIP-17266N|ensemblmetazoa:FBgn0003256(gene)|ensemblmetazoa:FBtr0113700(transcript)|ensemblmetazoa:FBtr0113702(transcript)|ensemblmetazoa:FBtr0113703(transcript)|ensemblmetazoa:FBtr0345337(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007362"(terminal region determination)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007479"(leg disc proximal/distal pattern formation)|go:"GO:0007552"(metamorphosis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035169"(lymph gland plasmatocyte differentiation)|go:"GO:0035170"(lymph gland crystal cell differentiation)|go:"GO:0035202"(tracheal pit formation in open tracheal system)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046534"(positive regulation of photoreceptor cell differentiation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000826"(regulation of heart morphogenesis)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P40417|reactome:R-DME-110056|reactome:R-DME-112409|reactome:R-DME-112411|reactome:R-DME-1295596|reactome:R-DME-162658|reactome:R-DME-170968|reactome:R-DME-198753|reactome:R-DME-202670|reactome:R-DME-2029482|reactome:R-DME-2559580|reactome:R-DME-2559582|reactome:R-DME-2559585|reactome:R-DME-2871796|reactome:R-DME-3371453|reactome:R-DME-375165|reactome:R-DME-437239|reactome:R-DME-445144|reactome:R-DME-450341|reactome:R-DME-456926|reactome:R-DME-5654726|reactome:R-DME-5654727|reactome:R-DME-5654732|reactome:R-DME-5654733|reactome:R-DME-5663213|reactome:R-DME-5673001|reactome:R-DME-5674135|reactome:R-DME-5674499|reactome:R-DME-5675221|reactome:R-DME-5687128|reactome:R-DME-6798695|reactome:R-DME-74749|reactome:R-DME-881907|reactome:R-DME-9634635|reactome:R-DME-9634638|mint:MINT-8075233(identity)	refseq:NP_524988.1|flybase:FBgn0040206|refseq:NP_001247400.1|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|reactome:R-DME-432720|reactome:R-DME-432722|reactome:R-DME-456926|reactome:R-DME-5099900|reactome:R-DME-5674135|reactome:R-DME-8856825|reactome:R-DME-8856828|ensemblmetazoa:FBgn0040206(gene)|ensemblmetazoa:FBtr0085877(transcript)|ensemblmetazoa:FBtr0305268(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0031648"(protein destabilization)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060189"(positive regulation of protein desumoylation)|go:"GO:0120177"(negative regulation of torso signaling pathway)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|mint:MINT-8075227(identity)	-	-	-	figure legend:f4a|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2010/11/26	2014/10/16	rogid:m7w7KhuZSyx3t+dR2TKtvx/vRtA7227	rogid:u4kgjQVpafnDKhPINoD7ftUYmNo7227	intact-crc:E88C6D1097B269E9|rigid:P0vKsKAmH2zoNQ06UZj7BYKQqFk	false	flag tag:?-?(MINT-8075234)	mutation increasing interaction:336-336(MINT-8075228)|ha tag:?-?(MINT-8075230)|mutation increasing interaction:209-209(MINT-8075238)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P40417	uniprotkb:Q9V393	intact:EBI-867790|uniprotkb:A0A021WW06|uniprotkb:Q7PL59|uniprotkb:Q9W5M2|uniprotkb:A8Y4W1|uniprotkb:A8Y4W2|uniprotkb:Q9W5M3|ensemblmetazoa:FBpp0112423|ensemblmetazoa:FBpp0112425|ensemblmetazoa:FBpp0112426|ensemblmetazoa:FBpp0311493	intact:EBI-100228|ensemblmetazoa:FBpp0085236|ensemblmetazoa:FBpp0293792	psi-mi:erka_drome(display_long)|uniprotkb:Extracellular-regulated kinase A(gene name synonym)|uniprotkb:Protein rolled(gene name synonym)|uniprotkb:rl(gene name)|psi-mi:rl(display_short)|uniprotkb:ERKa(gene name synonym)|uniprotkb:CG12559(orf name)|uniprotkb:MAPK(gene name synonym)	psi-mi:q9v393_drome(display_long)|uniprotkb:krz(gene name)|psi-mi:krz(display_short)|uniprotkb:CG1487(orf name)|uniprotkb:0952(gene name synonym)|uniprotkb:14(gene name synonym)|uniprotkb:Dmel\CG1487(gene name synonym)|uniprotkb:Krz(gene name synonym)|uniprotkb:Kurz(gene name synonym)|uniprotkb:"l(3)S095214"(gene name synonym)|uniprotkb:Dmel_CG1487(orf name)|uniprotkb:beta-arr2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tipping et al. (2010)	pubmed:20802461|imex:IM-15196|mint:MINT-8075200|doi:10.1038/emboj.2010.202	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8179443|mint:MINT-8075242|imex:IM-15196-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001015121.3|refseq:NP_001104348.2|refseq:NP_001287635.1|refseq:NP_001015122.1|refseq:NP_001015123.1|refseq:NP_001104349.1|flybase:FBgn0003256|dip:DIP-17266N|ensemblmetazoa:FBgn0003256(gene)|ensemblmetazoa:FBtr0113700(transcript)|ensemblmetazoa:FBtr0113702(transcript)|ensemblmetazoa:FBtr0113703(transcript)|ensemblmetazoa:FBtr0345337(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007362"(terminal region determination)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007479"(leg disc proximal/distal pattern formation)|go:"GO:0007552"(metamorphosis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035169"(lymph gland plasmatocyte differentiation)|go:"GO:0035170"(lymph gland crystal cell differentiation)|go:"GO:0035202"(tracheal pit formation in open tracheal system)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046534"(positive regulation of photoreceptor cell differentiation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000826"(regulation of heart morphogenesis)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P40417|reactome:R-DME-110056|reactome:R-DME-112409|reactome:R-DME-112411|reactome:R-DME-1295596|reactome:R-DME-162658|reactome:R-DME-170968|reactome:R-DME-198753|reactome:R-DME-202670|reactome:R-DME-2029482|reactome:R-DME-2559580|reactome:R-DME-2559582|reactome:R-DME-2559585|reactome:R-DME-2871796|reactome:R-DME-3371453|reactome:R-DME-375165|reactome:R-DME-437239|reactome:R-DME-445144|reactome:R-DME-450341|reactome:R-DME-456926|reactome:R-DME-5654726|reactome:R-DME-5654727|reactome:R-DME-5654732|reactome:R-DME-5654733|reactome:R-DME-5663213|reactome:R-DME-5673001|reactome:R-DME-5674135|reactome:R-DME-5674499|reactome:R-DME-5675221|reactome:R-DME-5687128|reactome:R-DME-6798695|reactome:R-DME-74749|reactome:R-DME-881907|reactome:R-DME-9634635|reactome:R-DME-9634638|mint:MINT-8075252(identity)	refseq:NP_524988.1|flybase:FBgn0040206|refseq:NP_001247400.1|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|reactome:R-DME-432720|reactome:R-DME-432722|reactome:R-DME-456926|reactome:R-DME-5099900|reactome:R-DME-5674135|reactome:R-DME-8856825|reactome:R-DME-8856828|ensemblmetazoa:FBgn0040206(gene)|ensemblmetazoa:FBtr0085877(transcript)|ensemblmetazoa:FBtr0305268(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0031648"(protein destabilization)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060189"(positive regulation of protein desumoylation)|go:"GO:0120177"(negative regulation of torso signaling pathway)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|mint:MINT-8075244(identity)	-	-	-	figure legend:f4a|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2010/11/26	2014/10/16	rogid:m7w7KhuZSyx3t+dR2TKtvx/vRtA7227	rogid:u4kgjQVpafnDKhPINoD7ftUYmNo7227	intact-crc:0E0325C033DACCBF|rigid:P0vKsKAmH2zoNQ06UZj7BYKQqFk	false	flag tag:?-?(MINT-8075253)	ha tag:?-?(MINT-8075249)|mutation increasing interaction:209-209(MINT-8075245)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P40417	uniprotkb:Q9V393	intact:EBI-867790|uniprotkb:A0A021WW06|uniprotkb:Q7PL59|uniprotkb:Q9W5M2|uniprotkb:A8Y4W1|uniprotkb:A8Y4W2|uniprotkb:Q9W5M3|ensemblmetazoa:FBpp0112423|ensemblmetazoa:FBpp0112425|ensemblmetazoa:FBpp0112426|ensemblmetazoa:FBpp0311493	intact:EBI-100228|ensemblmetazoa:FBpp0085236|ensemblmetazoa:FBpp0293792	psi-mi:erka_drome(display_long)|uniprotkb:Extracellular-regulated kinase A(gene name synonym)|uniprotkb:Protein rolled(gene name synonym)|uniprotkb:rl(gene name)|psi-mi:rl(display_short)|uniprotkb:ERKa(gene name synonym)|uniprotkb:CG12559(orf name)|uniprotkb:MAPK(gene name synonym)	psi-mi:q9v393_drome(display_long)|uniprotkb:krz(gene name)|psi-mi:krz(display_short)|uniprotkb:CG1487(orf name)|uniprotkb:0952(gene name synonym)|uniprotkb:14(gene name synonym)|uniprotkb:Dmel\CG1487(gene name synonym)|uniprotkb:Krz(gene name synonym)|uniprotkb:Kurz(gene name synonym)|uniprotkb:"l(3)S095214"(gene name synonym)|uniprotkb:Dmel_CG1487(orf name)|uniprotkb:beta-arr2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tipping et al. (2010)	pubmed:20802461|imex:IM-15196|mint:MINT-8075200|doi:10.1038/emboj.2010.202	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8179464|mint:MINT-8075258|imex:IM-15196-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001015121.3|refseq:NP_001104348.2|refseq:NP_001287635.1|refseq:NP_001015122.1|refseq:NP_001015123.1|refseq:NP_001104349.1|flybase:FBgn0003256|dip:DIP-17266N|ensemblmetazoa:FBgn0003256(gene)|ensemblmetazoa:FBtr0113700(transcript)|ensemblmetazoa:FBtr0113702(transcript)|ensemblmetazoa:FBtr0113703(transcript)|ensemblmetazoa:FBtr0345337(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007362"(terminal region determination)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007479"(leg disc proximal/distal pattern formation)|go:"GO:0007552"(metamorphosis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035169"(lymph gland plasmatocyte differentiation)|go:"GO:0035170"(lymph gland crystal cell differentiation)|go:"GO:0035202"(tracheal pit formation in open tracheal system)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046534"(positive regulation of photoreceptor cell differentiation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000826"(regulation of heart morphogenesis)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P40417|reactome:R-DME-110056|reactome:R-DME-112409|reactome:R-DME-112411|reactome:R-DME-1295596|reactome:R-DME-162658|reactome:R-DME-170968|reactome:R-DME-198753|reactome:R-DME-202670|reactome:R-DME-2029482|reactome:R-DME-2559580|reactome:R-DME-2559582|reactome:R-DME-2559585|reactome:R-DME-2871796|reactome:R-DME-3371453|reactome:R-DME-375165|reactome:R-DME-437239|reactome:R-DME-445144|reactome:R-DME-450341|reactome:R-DME-456926|reactome:R-DME-5654726|reactome:R-DME-5654727|reactome:R-DME-5654732|reactome:R-DME-5654733|reactome:R-DME-5663213|reactome:R-DME-5673001|reactome:R-DME-5674135|reactome:R-DME-5674499|reactome:R-DME-5675221|reactome:R-DME-5687128|reactome:R-DME-6798695|reactome:R-DME-74749|reactome:R-DME-881907|reactome:R-DME-9634635|reactome:R-DME-9634638|mint:MINT-8075266(identity)	refseq:NP_524988.1|flybase:FBgn0040206|refseq:NP_001247400.1|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|reactome:R-DME-432720|reactome:R-DME-432722|reactome:R-DME-456926|reactome:R-DME-5099900|reactome:R-DME-5674135|reactome:R-DME-8856825|reactome:R-DME-8856828|ensemblmetazoa:FBgn0040206(gene)|ensemblmetazoa:FBtr0085877(transcript)|ensemblmetazoa:FBtr0305268(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0031648"(protein destabilization)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060189"(positive regulation of protein desumoylation)|go:"GO:0120177"(negative regulation of torso signaling pathway)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|mint:MINT-8075260(identity)	-	-	-	figure legend:f4c|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2010/11/26	2014/10/16	rogid:m7w7KhuZSyx3t+dR2TKtvx/vRtA7227	rogid:u4kgjQVpafnDKhPINoD7ftUYmNo7227	intact-crc:2957A49F1DE595C5|rigid:P0vKsKAmH2zoNQ06UZj7BYKQqFk	false	mutation decreasing interaction:148-148(MINT-8075273)|flag tag:?-?(MINT-8075267)	ha tag:?-?(MINT-8075261)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P40417	uniprotkb:Q9V393	intact:EBI-867790|uniprotkb:A0A021WW06|uniprotkb:Q7PL59|uniprotkb:Q9W5M2|uniprotkb:A8Y4W1|uniprotkb:A8Y4W2|uniprotkb:Q9W5M3|ensemblmetazoa:FBpp0112423|ensemblmetazoa:FBpp0112425|ensemblmetazoa:FBpp0112426|ensemblmetazoa:FBpp0311493	intact:EBI-100228|ensemblmetazoa:FBpp0085236|ensemblmetazoa:FBpp0293792	psi-mi:erka_drome(display_long)|uniprotkb:Extracellular-regulated kinase A(gene name synonym)|uniprotkb:Protein rolled(gene name synonym)|uniprotkb:rl(gene name)|psi-mi:rl(display_short)|uniprotkb:ERKa(gene name synonym)|uniprotkb:CG12559(orf name)|uniprotkb:MAPK(gene name synonym)	psi-mi:q9v393_drome(display_long)|uniprotkb:krz(gene name)|psi-mi:krz(display_short)|uniprotkb:CG1487(orf name)|uniprotkb:0952(gene name synonym)|uniprotkb:14(gene name synonym)|uniprotkb:Dmel\CG1487(gene name synonym)|uniprotkb:Krz(gene name synonym)|uniprotkb:Kurz(gene name synonym)|uniprotkb:"l(3)S095214"(gene name synonym)|uniprotkb:Dmel_CG1487(orf name)|uniprotkb:beta-arr2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tipping et al. (2010)	pubmed:20802461|imex:IM-15196|mint:MINT-8075200|doi:10.1038/emboj.2010.202	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8179485|mint:MINT-8075277|imex:IM-15196-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001015121.3|refseq:NP_001104348.2|refseq:NP_001287635.1|refseq:NP_001015122.1|refseq:NP_001015123.1|refseq:NP_001104349.1|flybase:FBgn0003256|dip:DIP-17266N|ensemblmetazoa:FBgn0003256(gene)|ensemblmetazoa:FBtr0113700(transcript)|ensemblmetazoa:FBtr0113702(transcript)|ensemblmetazoa:FBtr0113703(transcript)|ensemblmetazoa:FBtr0345337(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007362"(terminal region determination)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007479"(leg disc proximal/distal pattern formation)|go:"GO:0007552"(metamorphosis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035169"(lymph gland plasmatocyte differentiation)|go:"GO:0035170"(lymph gland crystal cell differentiation)|go:"GO:0035202"(tracheal pit formation in open tracheal system)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046534"(positive regulation of photoreceptor cell differentiation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000826"(regulation of heart morphogenesis)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P40417|reactome:R-DME-110056|reactome:R-DME-112409|reactome:R-DME-112411|reactome:R-DME-1295596|reactome:R-DME-162658|reactome:R-DME-170968|reactome:R-DME-198753|reactome:R-DME-202670|reactome:R-DME-2029482|reactome:R-DME-2559580|reactome:R-DME-2559582|reactome:R-DME-2559585|reactome:R-DME-2871796|reactome:R-DME-3371453|reactome:R-DME-375165|reactome:R-DME-437239|reactome:R-DME-445144|reactome:R-DME-450341|reactome:R-DME-456926|reactome:R-DME-5654726|reactome:R-DME-5654727|reactome:R-DME-5654732|reactome:R-DME-5654733|reactome:R-DME-5663213|reactome:R-DME-5673001|reactome:R-DME-5674135|reactome:R-DME-5674499|reactome:R-DME-5675221|reactome:R-DME-5687128|reactome:R-DME-6798695|reactome:R-DME-74749|reactome:R-DME-881907|reactome:R-DME-9634635|reactome:R-DME-9634638|mint:MINT-8075283(identity)	refseq:NP_524988.1|flybase:FBgn0040206|refseq:NP_001247400.1|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|reactome:R-DME-432720|reactome:R-DME-432722|reactome:R-DME-456926|reactome:R-DME-5099900|reactome:R-DME-5674135|reactome:R-DME-8856825|reactome:R-DME-8856828|ensemblmetazoa:FBgn0040206(gene)|ensemblmetazoa:FBtr0085877(transcript)|ensemblmetazoa:FBtr0305268(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0031648"(protein destabilization)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060189"(positive regulation of protein desumoylation)|go:"GO:0120177"(negative regulation of torso signaling pathway)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|mint:MINT-8075279(identity)	-	-	-	figure legend:f4c|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2010/11/26	2014/10/16	rogid:m7w7KhuZSyx3t+dR2TKtvx/vRtA7227	rogid:u4kgjQVpafnDKhPINoD7ftUYmNo7227	intact-crc:47F437324A259595|rigid:P0vKsKAmH2zoNQ06UZj7BYKQqFk	false	mutation disrupting interaction:150-150(MINT-8075290)|mutation disrupting interaction:148-148(MINT-8075284)|flag tag:?-?(MINT-8075286)	ha tag:?-?(MINT-8075280)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P40417	uniprotkb:Q9V393	intact:EBI-867790|uniprotkb:A0A021WW06|uniprotkb:Q7PL59|uniprotkb:Q9W5M2|uniprotkb:A8Y4W1|uniprotkb:A8Y4W2|uniprotkb:Q9W5M3|ensemblmetazoa:FBpp0112423|ensemblmetazoa:FBpp0112425|ensemblmetazoa:FBpp0112426|ensemblmetazoa:FBpp0311493	intact:EBI-100228|ensemblmetazoa:FBpp0085236|ensemblmetazoa:FBpp0293792	psi-mi:erka_drome(display_long)|uniprotkb:Extracellular-regulated kinase A(gene name synonym)|uniprotkb:Protein rolled(gene name synonym)|uniprotkb:rl(gene name)|psi-mi:rl(display_short)|uniprotkb:ERKa(gene name synonym)|uniprotkb:CG12559(orf name)|uniprotkb:MAPK(gene name synonym)	psi-mi:q9v393_drome(display_long)|uniprotkb:krz(gene name)|psi-mi:krz(display_short)|uniprotkb:CG1487(orf name)|uniprotkb:0952(gene name synonym)|uniprotkb:14(gene name synonym)|uniprotkb:Dmel\CG1487(gene name synonym)|uniprotkb:Krz(gene name synonym)|uniprotkb:Kurz(gene name synonym)|uniprotkb:"l(3)S095214"(gene name synonym)|uniprotkb:Dmel_CG1487(orf name)|uniprotkb:beta-arr2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tipping et al. (2010)	pubmed:20802461|imex:IM-15196|mint:MINT-8075200|doi:10.1038/emboj.2010.202	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8179510|mint:MINT-8075294|imex:IM-15196-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001015121.3|refseq:NP_001104348.2|refseq:NP_001287635.1|refseq:NP_001015122.1|refseq:NP_001015123.1|refseq:NP_001104349.1|flybase:FBgn0003256|dip:DIP-17266N|ensemblmetazoa:FBgn0003256(gene)|ensemblmetazoa:FBtr0113700(transcript)|ensemblmetazoa:FBtr0113702(transcript)|ensemblmetazoa:FBtr0113703(transcript)|ensemblmetazoa:FBtr0345337(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007362"(terminal region determination)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007479"(leg disc proximal/distal pattern formation)|go:"GO:0007552"(metamorphosis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035169"(lymph gland plasmatocyte differentiation)|go:"GO:0035170"(lymph gland crystal cell differentiation)|go:"GO:0035202"(tracheal pit formation in open tracheal system)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046534"(positive regulation of photoreceptor cell differentiation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000826"(regulation of heart morphogenesis)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P40417|reactome:R-DME-110056|reactome:R-DME-112409|reactome:R-DME-112411|reactome:R-DME-1295596|reactome:R-DME-162658|reactome:R-DME-170968|reactome:R-DME-198753|reactome:R-DME-202670|reactome:R-DME-2029482|reactome:R-DME-2559580|reactome:R-DME-2559582|reactome:R-DME-2559585|reactome:R-DME-2871796|reactome:R-DME-3371453|reactome:R-DME-375165|reactome:R-DME-437239|reactome:R-DME-445144|reactome:R-DME-450341|reactome:R-DME-456926|reactome:R-DME-5654726|reactome:R-DME-5654727|reactome:R-DME-5654732|reactome:R-DME-5654733|reactome:R-DME-5663213|reactome:R-DME-5673001|reactome:R-DME-5674135|reactome:R-DME-5674499|reactome:R-DME-5675221|reactome:R-DME-5687128|reactome:R-DME-6798695|reactome:R-DME-74749|reactome:R-DME-881907|reactome:R-DME-9634635|reactome:R-DME-9634638|mint:MINT-8075300(identity)	refseq:NP_524988.1|flybase:FBgn0040206|refseq:NP_001247400.1|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|reactome:R-DME-432720|reactome:R-DME-432722|reactome:R-DME-456926|reactome:R-DME-5099900|reactome:R-DME-5674135|reactome:R-DME-8856825|reactome:R-DME-8856828|ensemblmetazoa:FBgn0040206(gene)|ensemblmetazoa:FBtr0085877(transcript)|ensemblmetazoa:FBtr0305268(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0031648"(protein destabilization)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060189"(positive regulation of protein desumoylation)|go:"GO:0120177"(negative regulation of torso signaling pathway)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|mint:MINT-8075296(identity)	-	-	-	figure legend:f4c|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2010/11/26	2014/10/16	rogid:m7w7KhuZSyx3t+dR2TKtvx/vRtA7227	rogid:u4kgjQVpafnDKhPINoD7ftUYmNo7227	intact-crc:DB8EC2FE13CC5C4D|rigid:P0vKsKAmH2zoNQ06UZj7BYKQqFk	false	mutation disrupting interaction:150-150(MINT-8075301)|flag tag:?-?(MINT-8075305)	ha tag:?-?(MINT-8075297)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P40417	uniprotkb:Q9V393	intact:EBI-867790|uniprotkb:A0A021WW06|uniprotkb:Q7PL59|uniprotkb:Q9W5M2|uniprotkb:A8Y4W1|uniprotkb:A8Y4W2|uniprotkb:Q9W5M3|ensemblmetazoa:FBpp0112423|ensemblmetazoa:FBpp0112425|ensemblmetazoa:FBpp0112426|ensemblmetazoa:FBpp0311493	intact:EBI-100228|ensemblmetazoa:FBpp0085236|ensemblmetazoa:FBpp0293792	psi-mi:erka_drome(display_long)|uniprotkb:Extracellular-regulated kinase A(gene name synonym)|uniprotkb:Protein rolled(gene name synonym)|uniprotkb:rl(gene name)|psi-mi:rl(display_short)|uniprotkb:ERKa(gene name synonym)|uniprotkb:CG12559(orf name)|uniprotkb:MAPK(gene name synonym)	psi-mi:q9v393_drome(display_long)|uniprotkb:krz(gene name)|psi-mi:krz(display_short)|uniprotkb:CG1487(orf name)|uniprotkb:0952(gene name synonym)|uniprotkb:14(gene name synonym)|uniprotkb:Dmel\CG1487(gene name synonym)|uniprotkb:Krz(gene name synonym)|uniprotkb:Kurz(gene name synonym)|uniprotkb:"l(3)S095214"(gene name synonym)|uniprotkb:Dmel_CG1487(orf name)|uniprotkb:beta-arr2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tipping et al. (2010)	pubmed:20802461|imex:IM-15196|mint:MINT-8075200|doi:10.1038/emboj.2010.202	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8179531|mint:MINT-8075310|imex:IM-15196-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001015121.3|refseq:NP_001104348.2|refseq:NP_001287635.1|refseq:NP_001015122.1|refseq:NP_001015123.1|refseq:NP_001104349.1|flybase:FBgn0003256|dip:DIP-17266N|ensemblmetazoa:FBgn0003256(gene)|ensemblmetazoa:FBtr0113700(transcript)|ensemblmetazoa:FBtr0113702(transcript)|ensemblmetazoa:FBtr0113703(transcript)|ensemblmetazoa:FBtr0345337(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007362"(terminal region determination)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007479"(leg disc proximal/distal pattern formation)|go:"GO:0007552"(metamorphosis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035169"(lymph gland plasmatocyte differentiation)|go:"GO:0035170"(lymph gland crystal cell differentiation)|go:"GO:0035202"(tracheal pit formation in open tracheal system)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046534"(positive regulation of photoreceptor cell differentiation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000826"(regulation of heart morphogenesis)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P40417|reactome:R-DME-110056|reactome:R-DME-112409|reactome:R-DME-112411|reactome:R-DME-1295596|reactome:R-DME-162658|reactome:R-DME-170968|reactome:R-DME-198753|reactome:R-DME-202670|reactome:R-DME-2029482|reactome:R-DME-2559580|reactome:R-DME-2559582|reactome:R-DME-2559585|reactome:R-DME-2871796|reactome:R-DME-3371453|reactome:R-DME-375165|reactome:R-DME-437239|reactome:R-DME-445144|reactome:R-DME-450341|reactome:R-DME-456926|reactome:R-DME-5654726|reactome:R-DME-5654727|reactome:R-DME-5654732|reactome:R-DME-5654733|reactome:R-DME-5663213|reactome:R-DME-5673001|reactome:R-DME-5674135|reactome:R-DME-5674499|reactome:R-DME-5675221|reactome:R-DME-5687128|reactome:R-DME-6798695|reactome:R-DME-74749|reactome:R-DME-881907|reactome:R-DME-9634635|reactome:R-DME-9634638|mint:MINT-8075316(identity)	refseq:NP_524988.1|flybase:FBgn0040206|refseq:NP_001247400.1|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|reactome:R-DME-432720|reactome:R-DME-432722|reactome:R-DME-456926|reactome:R-DME-5099900|reactome:R-DME-5674135|reactome:R-DME-8856825|reactome:R-DME-8856828|ensemblmetazoa:FBgn0040206(gene)|ensemblmetazoa:FBtr0085877(transcript)|ensemblmetazoa:FBtr0305268(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0031648"(protein destabilization)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060189"(positive regulation of protein desumoylation)|go:"GO:0120177"(negative regulation of torso signaling pathway)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|mint:MINT-8075312(identity)	-	-	-	figure legend:f4d|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2010/11/26	2014/10/16	rogid:m7w7KhuZSyx3t+dR2TKtvx/vRtA7227	rogid:u4kgjQVpafnDKhPINoD7ftUYmNo7227	intact-crc:65D1435EEF022124|rigid:P0vKsKAmH2zoNQ06UZj7BYKQqFk	false	mutation decreasing interaction:284-284(MINT-8075319)|flag tag:?-?(MINT-8075317)	ha tag:?-?(MINT-8075313)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9V393	uniprotkb:P40417	intact:EBI-100228|ensemblmetazoa:FBpp0085236|ensemblmetazoa:FBpp0293792	intact:EBI-867790|uniprotkb:A0A021WW06|uniprotkb:Q7PL59|uniprotkb:Q9W5M2|uniprotkb:A8Y4W1|uniprotkb:A8Y4W2|uniprotkb:Q9W5M3|ensemblmetazoa:FBpp0112423|ensemblmetazoa:FBpp0112425|ensemblmetazoa:FBpp0112426|ensemblmetazoa:FBpp0311493	psi-mi:q9v393_drome(display_long)|uniprotkb:krz(gene name)|psi-mi:krz(display_short)|uniprotkb:CG1487(orf name)|uniprotkb:0952(gene name synonym)|uniprotkb:14(gene name synonym)|uniprotkb:Dmel\CG1487(gene name synonym)|uniprotkb:Krz(gene name synonym)|uniprotkb:Kurz(gene name synonym)|uniprotkb:"l(3)S095214"(gene name synonym)|uniprotkb:Dmel_CG1487(orf name)|uniprotkb:beta-arr2(gene name synonym)	psi-mi:erka_drome(display_long)|uniprotkb:Extracellular-regulated kinase A(gene name synonym)|uniprotkb:Protein rolled(gene name synonym)|uniprotkb:rl(gene name)|psi-mi:rl(display_short)|uniprotkb:ERKa(gene name synonym)|uniprotkb:CG12559(orf name)|uniprotkb:MAPK(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tipping et al. (2010)	pubmed:20802461|imex:IM-15196|mint:MINT-8075200|doi:10.1038/emboj.2010.202	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8179575|mint:MINT-8075325|imex:IM-15196-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524988.1|flybase:FBgn0040206|refseq:NP_001247400.1|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|reactome:R-DME-432720|reactome:R-DME-432722|reactome:R-DME-456926|reactome:R-DME-5099900|reactome:R-DME-5674135|reactome:R-DME-8856825|reactome:R-DME-8856828|ensemblmetazoa:FBgn0040206(gene)|ensemblmetazoa:FBtr0085877(transcript)|ensemblmetazoa:FBtr0305268(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0031648"(protein destabilization)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060189"(positive regulation of protein desumoylation)|go:"GO:0120177"(negative regulation of torso signaling pathway)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|mint:MINT-8075327(identity)	refseq:NP_001015121.3|refseq:NP_001104348.2|refseq:NP_001287635.1|refseq:NP_001015122.1|refseq:NP_001015123.1|refseq:NP_001104349.1|flybase:FBgn0003256|dip:DIP-17266N|ensemblmetazoa:FBgn0003256(gene)|ensemblmetazoa:FBtr0113700(transcript)|ensemblmetazoa:FBtr0113702(transcript)|ensemblmetazoa:FBtr0113703(transcript)|ensemblmetazoa:FBtr0345337(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007362"(terminal region determination)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007479"(leg disc proximal/distal pattern formation)|go:"GO:0007552"(metamorphosis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035169"(lymph gland plasmatocyte differentiation)|go:"GO:0035170"(lymph gland crystal cell differentiation)|go:"GO:0035202"(tracheal pit formation in open tracheal system)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046534"(positive regulation of photoreceptor cell differentiation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000826"(regulation of heart morphogenesis)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P40417|reactome:R-DME-110056|reactome:R-DME-112409|reactome:R-DME-112411|reactome:R-DME-1295596|reactome:R-DME-162658|reactome:R-DME-170968|reactome:R-DME-198753|reactome:R-DME-202670|reactome:R-DME-2029482|reactome:R-DME-2559580|reactome:R-DME-2559582|reactome:R-DME-2559585|reactome:R-DME-2871796|reactome:R-DME-3371453|reactome:R-DME-375165|reactome:R-DME-437239|reactome:R-DME-445144|reactome:R-DME-450341|reactome:R-DME-456926|reactome:R-DME-5654726|reactome:R-DME-5654727|reactome:R-DME-5654732|reactome:R-DME-5654733|reactome:R-DME-5663213|reactome:R-DME-5673001|reactome:R-DME-5674135|reactome:R-DME-5674499|reactome:R-DME-5675221|reactome:R-DME-5687128|reactome:R-DME-6798695|reactome:R-DME-74749|reactome:R-DME-881907|reactome:R-DME-9634635|reactome:R-DME-9634638|mint:MINT-8075331(identity)	-	-	-	figure legend:f4e|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2010/11/26	2014/10/16	rogid:u4kgjQVpafnDKhPINoD7ftUYmNo7227	rogid:m7w7KhuZSyx3t+dR2TKtvx/vRtA7227	intact-crc:47F437324A25920B|rigid:P0vKsKAmH2zoNQ06UZj7BYKQqFk	false	ha tag:?-?(MINT-8075328)	mutation disrupting interaction:148-148(MINT-8075334)|mutation disrupting interaction:150-150(MINT-8075332)|flag tag:?-?(MINT-8075336)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9V393	uniprotkb:P40417	intact:EBI-100228|ensemblmetazoa:FBpp0085236|ensemblmetazoa:FBpp0293792	intact:EBI-867790|uniprotkb:A0A021WW06|uniprotkb:Q7PL59|uniprotkb:Q9W5M2|uniprotkb:A8Y4W1|uniprotkb:A8Y4W2|uniprotkb:Q9W5M3|ensemblmetazoa:FBpp0112423|ensemblmetazoa:FBpp0112425|ensemblmetazoa:FBpp0112426|ensemblmetazoa:FBpp0311493	psi-mi:q9v393_drome(display_long)|uniprotkb:krz(gene name)|psi-mi:krz(display_short)|uniprotkb:CG1487(orf name)|uniprotkb:0952(gene name synonym)|uniprotkb:14(gene name synonym)|uniprotkb:Dmel\CG1487(gene name synonym)|uniprotkb:Krz(gene name synonym)|uniprotkb:Kurz(gene name synonym)|uniprotkb:"l(3)S095214"(gene name synonym)|uniprotkb:Dmel_CG1487(orf name)|uniprotkb:beta-arr2(gene name synonym)	psi-mi:erka_drome(display_long)|uniprotkb:Extracellular-regulated kinase A(gene name synonym)|uniprotkb:Protein rolled(gene name synonym)|uniprotkb:rl(gene name)|psi-mi:rl(display_short)|uniprotkb:ERKa(gene name synonym)|uniprotkb:CG12559(orf name)|uniprotkb:MAPK(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tipping et al. (2010)	pubmed:20802461|imex:IM-15196|mint:MINT-8075200|doi:10.1038/emboj.2010.202	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8179676|mint:MINT-8075374|imex:IM-15196-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524988.1|flybase:FBgn0040206|refseq:NP_001247400.1|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|reactome:R-DME-432720|reactome:R-DME-432722|reactome:R-DME-456926|reactome:R-DME-5099900|reactome:R-DME-5674135|reactome:R-DME-8856825|reactome:R-DME-8856828|ensemblmetazoa:FBgn0040206(gene)|ensemblmetazoa:FBtr0085877(transcript)|ensemblmetazoa:FBtr0305268(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0031648"(protein destabilization)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060189"(positive regulation of protein desumoylation)|go:"GO:0120177"(negative regulation of torso signaling pathway)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|mint:MINT-8075376(identity)	refseq:NP_001015121.3|refseq:NP_001104348.2|refseq:NP_001287635.1|refseq:NP_001015122.1|refseq:NP_001015123.1|refseq:NP_001104349.1|flybase:FBgn0003256|dip:DIP-17266N|ensemblmetazoa:FBgn0003256(gene)|ensemblmetazoa:FBtr0113700(transcript)|ensemblmetazoa:FBtr0113702(transcript)|ensemblmetazoa:FBtr0113703(transcript)|ensemblmetazoa:FBtr0345337(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007362"(terminal region determination)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007479"(leg disc proximal/distal pattern formation)|go:"GO:0007552"(metamorphosis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035169"(lymph gland plasmatocyte differentiation)|go:"GO:0035170"(lymph gland crystal cell differentiation)|go:"GO:0035202"(tracheal pit formation in open tracheal system)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046534"(positive regulation of photoreceptor cell differentiation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000826"(regulation of heart morphogenesis)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P40417|reactome:R-DME-110056|reactome:R-DME-112409|reactome:R-DME-112411|reactome:R-DME-1295596|reactome:R-DME-162658|reactome:R-DME-170968|reactome:R-DME-198753|reactome:R-DME-202670|reactome:R-DME-2029482|reactome:R-DME-2559580|reactome:R-DME-2559582|reactome:R-DME-2559585|reactome:R-DME-2871796|reactome:R-DME-3371453|reactome:R-DME-375165|reactome:R-DME-437239|reactome:R-DME-445144|reactome:R-DME-450341|reactome:R-DME-456926|reactome:R-DME-5654726|reactome:R-DME-5654727|reactome:R-DME-5654732|reactome:R-DME-5654733|reactome:R-DME-5663213|reactome:R-DME-5673001|reactome:R-DME-5674135|reactome:R-DME-5674499|reactome:R-DME-5675221|reactome:R-DME-5687128|reactome:R-DME-6798695|reactome:R-DME-74749|reactome:R-DME-881907|reactome:R-DME-9634635|reactome:R-DME-9634638|mint:MINT-8075380(identity)	-	-	-	comment:mint|figure legend:sf6d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2010/11/26	2014/10/16	rogid:u4kgjQVpafnDKhPINoD7ftUYmNo7227	rogid:m7w7KhuZSyx3t+dR2TKtvx/vRtA7227	intact-crc:5AFCB8E3A9A11DB6|rigid:P0vKsKAmH2zoNQ06UZj7BYKQqFk	false	myc tag:?-?(MINT-8075377)	flag tag:?-?(MINT-8075381)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9V393	uniprotkb:P40417	intact:EBI-100228|ensemblmetazoa:FBpp0085236|ensemblmetazoa:FBpp0293792	intact:EBI-867790|uniprotkb:A0A021WW06|uniprotkb:Q7PL59|uniprotkb:Q9W5M2|uniprotkb:A8Y4W1|uniprotkb:A8Y4W2|uniprotkb:Q9W5M3|ensemblmetazoa:FBpp0112423|ensemblmetazoa:FBpp0112425|ensemblmetazoa:FBpp0112426|ensemblmetazoa:FBpp0311493	psi-mi:q9v393_drome(display_long)|uniprotkb:krz(gene name)|psi-mi:krz(display_short)|uniprotkb:CG1487(orf name)|uniprotkb:0952(gene name synonym)|uniprotkb:14(gene name synonym)|uniprotkb:Dmel\CG1487(gene name synonym)|uniprotkb:Krz(gene name synonym)|uniprotkb:Kurz(gene name synonym)|uniprotkb:"l(3)S095214"(gene name synonym)|uniprotkb:Dmel_CG1487(orf name)|uniprotkb:beta-arr2(gene name synonym)	psi-mi:erka_drome(display_long)|uniprotkb:Extracellular-regulated kinase A(gene name synonym)|uniprotkb:Protein rolled(gene name synonym)|uniprotkb:rl(gene name)|psi-mi:rl(display_short)|uniprotkb:ERKa(gene name synonym)|uniprotkb:CG12559(orf name)|uniprotkb:MAPK(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tipping et al. (2010)	pubmed:20802461|imex:IM-15196|mint:MINT-8075200|doi:10.1038/emboj.2010.202	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8179621|mint:MINT-8075359|imex:IM-15196-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524988.1|flybase:FBgn0040206|refseq:NP_001247400.1|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|reactome:R-DME-432720|reactome:R-DME-432722|reactome:R-DME-456926|reactome:R-DME-5099900|reactome:R-DME-5674135|reactome:R-DME-8856825|reactome:R-DME-8856828|ensemblmetazoa:FBgn0040206(gene)|ensemblmetazoa:FBtr0085877(transcript)|ensemblmetazoa:FBtr0305268(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0031648"(protein destabilization)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060189"(positive regulation of protein desumoylation)|go:"GO:0120177"(negative regulation of torso signaling pathway)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|mint:MINT-8075361(identity)	refseq:NP_001015121.3|refseq:NP_001104348.2|refseq:NP_001287635.1|refseq:NP_001015122.1|refseq:NP_001015123.1|refseq:NP_001104349.1|flybase:FBgn0003256|dip:DIP-17266N|ensemblmetazoa:FBgn0003256(gene)|ensemblmetazoa:FBtr0113700(transcript)|ensemblmetazoa:FBtr0113702(transcript)|ensemblmetazoa:FBtr0113703(transcript)|ensemblmetazoa:FBtr0345337(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007362"(terminal region determination)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007479"(leg disc proximal/distal pattern formation)|go:"GO:0007552"(metamorphosis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035169"(lymph gland plasmatocyte differentiation)|go:"GO:0035170"(lymph gland crystal cell differentiation)|go:"GO:0035202"(tracheal pit formation in open tracheal system)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046534"(positive regulation of photoreceptor cell differentiation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000826"(regulation of heart morphogenesis)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P40417|reactome:R-DME-110056|reactome:R-DME-112409|reactome:R-DME-112411|reactome:R-DME-1295596|reactome:R-DME-162658|reactome:R-DME-170968|reactome:R-DME-198753|reactome:R-DME-202670|reactome:R-DME-2029482|reactome:R-DME-2559580|reactome:R-DME-2559582|reactome:R-DME-2559585|reactome:R-DME-2871796|reactome:R-DME-3371453|reactome:R-DME-375165|reactome:R-DME-437239|reactome:R-DME-445144|reactome:R-DME-450341|reactome:R-DME-456926|reactome:R-DME-5654726|reactome:R-DME-5654727|reactome:R-DME-5654732|reactome:R-DME-5654733|reactome:R-DME-5663213|reactome:R-DME-5673001|reactome:R-DME-5674135|reactome:R-DME-5674499|reactome:R-DME-5675221|reactome:R-DME-5687128|reactome:R-DME-6798695|reactome:R-DME-74749|reactome:R-DME-881907|reactome:R-DME-9634635|reactome:R-DME-9634638|mint:MINT-8075365(identity)	-	-	-	comment:mint|figure legend:f4b f5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2010/11/26	2014/10/16	rogid:u4kgjQVpafnDKhPINoD7ftUYmNo7227	rogid:m7w7KhuZSyx3t+dR2TKtvx/vRtA7227	intact-crc:8E6494DA0DC95E21|rigid:P0vKsKAmH2zoNQ06UZj7BYKQqFk	false	ha tag:?-?(MINT-8075362)	flag tag:?-?(MINT-8075368)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P40417	uniprotkb:Q9V393	intact:EBI-867790|uniprotkb:A0A021WW06|uniprotkb:Q7PL59|uniprotkb:Q9W5M2|uniprotkb:A8Y4W1|uniprotkb:A8Y4W2|uniprotkb:Q9W5M3|ensemblmetazoa:FBpp0112423|ensemblmetazoa:FBpp0112425|ensemblmetazoa:FBpp0112426|ensemblmetazoa:FBpp0311493	intact:EBI-100228|ensemblmetazoa:FBpp0085236|ensemblmetazoa:FBpp0293792	psi-mi:erka_drome(display_long)|uniprotkb:Extracellular-regulated kinase A(gene name synonym)|uniprotkb:Protein rolled(gene name synonym)|uniprotkb:rl(gene name)|psi-mi:rl(display_short)|uniprotkb:ERKa(gene name synonym)|uniprotkb:CG12559(orf name)|uniprotkb:MAPK(gene name synonym)	psi-mi:q9v393_drome(display_long)|uniprotkb:krz(gene name)|psi-mi:krz(display_short)|uniprotkb:CG1487(orf name)|uniprotkb:0952(gene name synonym)|uniprotkb:14(gene name synonym)|uniprotkb:Dmel\CG1487(gene name synonym)|uniprotkb:Krz(gene name synonym)|uniprotkb:Kurz(gene name synonym)|uniprotkb:"l(3)S095214"(gene name synonym)|uniprotkb:Dmel_CG1487(orf name)|uniprotkb:beta-arr2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tipping et al. (2010)	pubmed:20802461|imex:IM-15196|mint:MINT-8075200|doi:10.1038/emboj.2010.202	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8179600|mint:MINT-8075343|imex:IM-15196-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001015121.3|refseq:NP_001104348.2|refseq:NP_001287635.1|refseq:NP_001015122.1|refseq:NP_001015123.1|refseq:NP_001104349.1|flybase:FBgn0003256|dip:DIP-17266N|ensemblmetazoa:FBgn0003256(gene)|ensemblmetazoa:FBtr0113700(transcript)|ensemblmetazoa:FBtr0113702(transcript)|ensemblmetazoa:FBtr0113703(transcript)|ensemblmetazoa:FBtr0345337(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007362"(terminal region determination)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007479"(leg disc proximal/distal pattern formation)|go:"GO:0007552"(metamorphosis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035169"(lymph gland plasmatocyte differentiation)|go:"GO:0035170"(lymph gland crystal cell differentiation)|go:"GO:0035202"(tracheal pit formation in open tracheal system)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046534"(positive regulation of photoreceptor cell differentiation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000826"(regulation of heart morphogenesis)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P40417|reactome:R-DME-110056|reactome:R-DME-112409|reactome:R-DME-112411|reactome:R-DME-1295596|reactome:R-DME-162658|reactome:R-DME-170968|reactome:R-DME-198753|reactome:R-DME-202670|reactome:R-DME-2029482|reactome:R-DME-2559580|reactome:R-DME-2559582|reactome:R-DME-2559585|reactome:R-DME-2871796|reactome:R-DME-3371453|reactome:R-DME-375165|reactome:R-DME-437239|reactome:R-DME-445144|reactome:R-DME-450341|reactome:R-DME-456926|reactome:R-DME-5654726|reactome:R-DME-5654727|reactome:R-DME-5654732|reactome:R-DME-5654733|reactome:R-DME-5663213|reactome:R-DME-5673001|reactome:R-DME-5674135|reactome:R-DME-5674499|reactome:R-DME-5675221|reactome:R-DME-5687128|reactome:R-DME-6798695|reactome:R-DME-74749|reactome:R-DME-881907|reactome:R-DME-9634635|reactome:R-DME-9634638|mint:MINT-8075349(identity)	refseq:NP_524988.1|flybase:FBgn0040206|refseq:NP_001247400.1|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|reactome:R-DME-432720|reactome:R-DME-432722|reactome:R-DME-456926|reactome:R-DME-5099900|reactome:R-DME-5674135|reactome:R-DME-8856825|reactome:R-DME-8856828|ensemblmetazoa:FBgn0040206(gene)|ensemblmetazoa:FBtr0085877(transcript)|ensemblmetazoa:FBtr0305268(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0031648"(protein destabilization)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060189"(positive regulation of protein desumoylation)|go:"GO:0120177"(negative regulation of torso signaling pathway)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|mint:MINT-8075345(identity)	-	-	-	figure legend:f4e|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2010/11/26	2014/10/16	rogid:m7w7KhuZSyx3t+dR2TKtvx/vRtA7227	rogid:u4kgjQVpafnDKhPINoD7ftUYmNo7227	intact-crc:2957A49F1DE5925B|rigid:P0vKsKAmH2zoNQ06UZj7BYKQqFk	false	flag tag:?-?(MINT-8075350)|mutation decreasing interaction:148-148(MINT-8075352)	ha tag:?-?(MINT-8075346)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9V393	uniprotkb:Q03017	intact:EBI-100228|ensemblmetazoa:FBpp0085236|ensemblmetazoa:FBpp0293792	intact:EBI-200600|uniprotkb:A4V0S3|uniprotkb:Q0E8Q3|uniprotkb:Q9V3M6|ensemblmetazoa:FBpp0080402|ensemblmetazoa:FBpp0080403|ensemblmetazoa:FBpp0089296|ensemblmetazoa:FBpp0308004	psi-mi:q9v393_drome(display_long)|uniprotkb:krz(gene name)|psi-mi:krz(display_short)|uniprotkb:CG1487(orf name)|uniprotkb:0952(gene name synonym)|uniprotkb:14(gene name synonym)|uniprotkb:Dmel\CG1487(gene name synonym)|uniprotkb:Krz(gene name synonym)|uniprotkb:Kurz(gene name synonym)|uniprotkb:"l(3)S095214"(gene name synonym)|uniprotkb:Dmel_CG1487(orf name)|uniprotkb:beta-arr2(gene name synonym)	psi-mi:cact_drome(display_long)|uniprotkb:CG5848(orf name)|uniprotkb:cact(gene name)|psi-mi:cact(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tipping et al. (2010)	pubmed:20802461|imex:IM-15196|mint:MINT-8075200|doi:10.1038/emboj.2010.202	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8179713|mint:MINT-8075431|imex:IM-15196-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524988.1|flybase:FBgn0040206|refseq:NP_001247400.1|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|reactome:R-DME-432720|reactome:R-DME-432722|reactome:R-DME-456926|reactome:R-DME-5099900|reactome:R-DME-5674135|reactome:R-DME-8856825|reactome:R-DME-8856828|ensemblmetazoa:FBgn0040206(gene)|ensemblmetazoa:FBtr0085877(transcript)|ensemblmetazoa:FBtr0305268(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0031648"(protein destabilization)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060189"(positive regulation of protein desumoylation)|go:"GO:0120177"(negative regulation of torso signaling pathway)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|mint:MINT-8075433(identity)	refseq:NP_476942.1|refseq:NP_476943.1|refseq:NP_723960.1|refseq:NP_995721.1|flybase:FBgn0000250|refseq:NP_001260496.1|dip:DIP-17846N|ensemblmetazoa:FBgn0000250(gene)|ensemblmetazoa:FBtr0080844(transcript)|ensemblmetazoa:FBtr0080845(transcript)|ensemblmetazoa:FBtr0080847(transcript)|ensemblmetazoa:FBtr0337081(transcript)|go:"GO:0002789"(negative regulation of antifungal peptide production)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007399"(nervous system development)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019730"(antimicrobial humoral response)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0045611"(negative regulation of hemocyte differentiation)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048477"(oogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0071212"(subsynaptic reticulum)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|reactome:R-DME-1169091|reactome:R-DME-202424|reactome:R-DME-209406|reactome:R-DME-209560|reactome:R-DME-214842|reactome:R-DME-214844|reactome:R-DME-214869|reactome:R-DME-2871837|reactome:R-DME-445989|reactome:R-DME-5607764|reactome:R-DME-9020702|mint:MINT-8075437(identity)	-	-	-	comment:mint|figure legend:f7j|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2010/11/26	2014/10/16	rogid:u4kgjQVpafnDKhPINoD7ftUYmNo7227	rogid:xVqWiRJtkb1WDO5GmztYwgdB9iI7227	intact-crc:527B54949EABD03A|rigid:spjkbmCfogYcGD5JNXAiMMYYNsI	false	ha tag:?-?(MINT-8075434)	v5 tag:?-?(MINT-8075438)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P40417	uniprotkb:Q24324	intact:EBI-867790|uniprotkb:A0A021WW06|uniprotkb:Q7PL59|uniprotkb:Q9W5M2|uniprotkb:A8Y4W1|uniprotkb:A8Y4W2|uniprotkb:Q9W5M3|ensemblmetazoa:FBpp0112423|ensemblmetazoa:FBpp0112425|ensemblmetazoa:FBpp0112426|ensemblmetazoa:FBpp0311493	intact:EBI-671282|ensemblmetazoa:FBpp0071248|uniprotkb:Q8ISE0|uniprotkb:Q9W360	psi-mi:erka_drome(display_long)|uniprotkb:Extracellular-regulated kinase A(gene name synonym)|uniprotkb:Protein rolled(gene name synonym)|uniprotkb:rl(gene name)|psi-mi:rl(display_short)|uniprotkb:ERKa(gene name synonym)|uniprotkb:CG12559(orf name)|uniprotkb:MAPK(gene name synonym)	psi-mi:dsor1_drome(display_long)|uniprotkb:Dsor1(gene name)|psi-mi:Dsor1(display_short)|uniprotkb:CG15793(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tipping et al. (2010)	pubmed:20802461|imex:IM-15196|mint:MINT-8075200|doi:10.1038/emboj.2010.202	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8179730|mint:MINT-8075465|imex:IM-15196-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001015121.3|refseq:NP_001104348.2|refseq:NP_001287635.1|refseq:NP_001015122.1|refseq:NP_001015123.1|refseq:NP_001104349.1|flybase:FBgn0003256|dip:DIP-17266N|ensemblmetazoa:FBgn0003256(gene)|ensemblmetazoa:FBtr0113700(transcript)|ensemblmetazoa:FBtr0113702(transcript)|ensemblmetazoa:FBtr0113703(transcript)|ensemblmetazoa:FBtr0345337(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007362"(terminal region determination)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007479"(leg disc proximal/distal pattern formation)|go:"GO:0007552"(metamorphosis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035169"(lymph gland plasmatocyte differentiation)|go:"GO:0035170"(lymph gland crystal cell differentiation)|go:"GO:0035202"(tracheal pit formation in open tracheal system)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046534"(positive regulation of photoreceptor cell differentiation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000826"(regulation of heart morphogenesis)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P40417|reactome:R-DME-110056|reactome:R-DME-112409|reactome:R-DME-112411|reactome:R-DME-1295596|reactome:R-DME-162658|reactome:R-DME-170968|reactome:R-DME-198753|reactome:R-DME-202670|reactome:R-DME-2029482|reactome:R-DME-2559580|reactome:R-DME-2559582|reactome:R-DME-2559585|reactome:R-DME-2871796|reactome:R-DME-3371453|reactome:R-DME-375165|reactome:R-DME-437239|reactome:R-DME-445144|reactome:R-DME-450341|reactome:R-DME-456926|reactome:R-DME-5654726|reactome:R-DME-5654727|reactome:R-DME-5654732|reactome:R-DME-5654733|reactome:R-DME-5663213|reactome:R-DME-5673001|reactome:R-DME-5674135|reactome:R-DME-5674499|reactome:R-DME-5675221|reactome:R-DME-5687128|reactome:R-DME-6798695|reactome:R-DME-74749|reactome:R-DME-881907|reactome:R-DME-9634635|reactome:R-DME-9634638|mint:MINT-8075467(identity)	ensemblmetazoa:FBgn0010269(gene)|ensemblmetazoa:FBtr0071313(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007362"(terminal region determination)|go:"GO:0007430"(terminal branching, open tracheal system)|refseq:NP_511098.1|flybase:FBgn0010269|refseq:NP_001285044.1|dip:DIP-29770N|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019900"(kinase binding)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0042386"(hemocyte differentiation)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-DME-110056|reactome:R-DME-112411|reactome:R-DME-170968|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-432553|reactome:R-DME-445144|reactome:R-DME-5673000|reactome:R-DME-5674135|reactome:R-DME-5674499|mint:MINT-8075471(identity)	-	-	-	comment:homomint|comment:mint|figure legend:sf6b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2010/11/26	2014/10/16	rogid:m7w7KhuZSyx3t+dR2TKtvx/vRtA7227	rogid:FsIuc6ILmQjnAJmLsgb17lwXMU07227	intact-crc:55C89F7E21E6AFD3|rigid:O4mTid+0mgXkhPQrZoey6UTk+uY	false	mutation increasing interaction:159-159(MINT-8075484)|ha tag:?-?(MINT-8075468)	mutation increasing interaction:241-241(MINT-8075480)|v5 tag:?-?(MINT-8075472)|mutation increasing interaction:237-237(MINT-8075477)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q24324	uniprotkb:P40417	intact:EBI-671282|ensemblmetazoa:FBpp0071248|uniprotkb:Q8ISE0|uniprotkb:Q9W360	intact:EBI-867790|uniprotkb:A0A021WW06|uniprotkb:Q7PL59|uniprotkb:Q9W5M2|uniprotkb:A8Y4W1|uniprotkb:A8Y4W2|uniprotkb:Q9W5M3|ensemblmetazoa:FBpp0112423|ensemblmetazoa:FBpp0112425|ensemblmetazoa:FBpp0112426|ensemblmetazoa:FBpp0311493	psi-mi:dsor1_drome(display_long)|uniprotkb:Dsor1(gene name)|psi-mi:Dsor1(display_short)|uniprotkb:CG15793(orf name)	psi-mi:erka_drome(display_long)|uniprotkb:Extracellular-regulated kinase A(gene name synonym)|uniprotkb:Protein rolled(gene name synonym)|uniprotkb:rl(gene name)|psi-mi:rl(display_short)|uniprotkb:ERKa(gene name synonym)|uniprotkb:CG12559(orf name)|uniprotkb:MAPK(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tipping et al. (2010)	pubmed:20802461|imex:IM-15196|mint:MINT-8075200|doi:10.1038/emboj.2010.202	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8179694|mint:MINT-8075391|imex:IM-15196-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0010269(gene)|ensemblmetazoa:FBtr0071313(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007362"(terminal region determination)|go:"GO:0007430"(terminal branching, open tracheal system)|refseq:NP_511098.1|flybase:FBgn0010269|refseq:NP_001285044.1|dip:DIP-29770N|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019900"(kinase binding)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0042386"(hemocyte differentiation)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-DME-110056|reactome:R-DME-112411|reactome:R-DME-170968|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-432553|reactome:R-DME-445144|reactome:R-DME-5673000|reactome:R-DME-5674135|reactome:R-DME-5674499|mint:MINT-8075393(identity)	refseq:NP_001015121.3|refseq:NP_001104348.2|refseq:NP_001287635.1|refseq:NP_001015122.1|refseq:NP_001015123.1|refseq:NP_001104349.1|flybase:FBgn0003256|dip:DIP-17266N|ensemblmetazoa:FBgn0003256(gene)|ensemblmetazoa:FBtr0113700(transcript)|ensemblmetazoa:FBtr0113702(transcript)|ensemblmetazoa:FBtr0113703(transcript)|ensemblmetazoa:FBtr0345337(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007362"(terminal region determination)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007479"(leg disc proximal/distal pattern formation)|go:"GO:0007552"(metamorphosis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035169"(lymph gland plasmatocyte differentiation)|go:"GO:0035170"(lymph gland crystal cell differentiation)|go:"GO:0035202"(tracheal pit formation in open tracheal system)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046534"(positive regulation of photoreceptor cell differentiation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000826"(regulation of heart morphogenesis)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P40417|reactome:R-DME-110056|reactome:R-DME-112409|reactome:R-DME-112411|reactome:R-DME-1295596|reactome:R-DME-162658|reactome:R-DME-170968|reactome:R-DME-198753|reactome:R-DME-202670|reactome:R-DME-2029482|reactome:R-DME-2559580|reactome:R-DME-2559582|reactome:R-DME-2559585|reactome:R-DME-2871796|reactome:R-DME-3371453|reactome:R-DME-375165|reactome:R-DME-437239|reactome:R-DME-445144|reactome:R-DME-450341|reactome:R-DME-456926|reactome:R-DME-5654726|reactome:R-DME-5654727|reactome:R-DME-5654732|reactome:R-DME-5654733|reactome:R-DME-5663213|reactome:R-DME-5673001|reactome:R-DME-5674135|reactome:R-DME-5674499|reactome:R-DME-5675221|reactome:R-DME-5687128|reactome:R-DME-6798695|reactome:R-DME-74749|reactome:R-DME-881907|reactome:R-DME-9634635|reactome:R-DME-9634638|mint:MINT-8075397(identity)	-	-	-	comment:homomint|comment:mint|figure legend:sf6c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2010/11/26	2014/10/16	rogid:FsIuc6ILmQjnAJmLsgb17lwXMU07227	rogid:m7w7KhuZSyx3t+dR2TKtvx/vRtA7227	intact-crc:B6956A33FBD55003|rigid:O4mTid+0mgXkhPQrZoey6UTk+uY	false	v5 tag:?-?(MINT-8075394)	flag tag:?-?(MINT-8075398)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P11346	uniprotkb:Q9V393	intact:EBI-664624|uniprotkb:Q9W4Z3|uniprotkb:Q8I086|uniprotkb:Q8I0D9|uniprotkb:Q8ISE1|uniprotkb:Q8ISE2|uniprotkb:Q8ISE3|uniprotkb:Q9NEH9|uniprotkb:A8JUV5|uniprotkb:Q0KHW7|ensemblmetazoa:FBpp0070385|ensemblmetazoa:FBpp0310458	intact:EBI-100228|ensemblmetazoa:FBpp0085236|ensemblmetazoa:FBpp0293792	psi-mi:kraf1_drome(display_long)|uniprotkb:Raf(gene name)|psi-mi:Raf(display_short)|uniprotkb:Protein pole-hole(gene name synonym)|uniprotkb:ph(gene name synonym)|uniprotkb:phl(gene name synonym)|uniprotkb:CG2845(orf name)	psi-mi:q9v393_drome(display_long)|uniprotkb:krz(gene name)|psi-mi:krz(display_short)|uniprotkb:CG1487(orf name)|uniprotkb:0952(gene name synonym)|uniprotkb:14(gene name synonym)|uniprotkb:Dmel\CG1487(gene name synonym)|uniprotkb:Krz(gene name synonym)|uniprotkb:Kurz(gene name synonym)|uniprotkb:"l(3)S095214"(gene name synonym)|uniprotkb:Dmel_CG1487(orf name)|uniprotkb:beta-arr2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tipping et al. (2010)	pubmed:20802461|imex:IM-15196|mint:MINT-8075200|doi:10.1038/emboj.2010.202	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8179760|mint:MINT-8075487|imex:IM-15196-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_525047.1|flybase:FBgn0003079|refseq:NP_001096867.3|dip:DIP-29769N|ensemblmetazoa:FBgn0003079(gene)|ensemblmetazoa:FBtr0070401(transcript)|ensemblmetazoa:FBtr0344007(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0002168"(instar larval development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007362"(terminal region determination)|go:"GO:0007369"(gastrulation)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007472"(wing disc morphogenesis)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007552"(metamorphosis)|go:"GO:0008069"(dorsal/ventral axis specification, ovarian follicular epithelium)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035309"(wing and notum subfield formation)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042051"(compound eye photoreceptor development)|go:"GO:0042386"(hemocyte differentiation)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0046530"(photoreceptor cell differentiation)|go:"GO:0046534"(positive regulation of photoreceptor cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR029071|reactome:R-DME-1295596|reactome:R-DME-170968|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-392517|reactome:R-DME-430116|reactome:R-DME-432553|reactome:R-DME-5621575|reactome:R-DME-5673000|reactome:R-DME-5674135|reactome:R-DME-5674499|reactome:R-DME-5675221|reactome:R-DME-5675482|mint:MINT-8075489(identity)	refseq:NP_524988.1|flybase:FBgn0040206|refseq:NP_001247400.1|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|reactome:R-DME-432720|reactome:R-DME-432722|reactome:R-DME-456926|reactome:R-DME-5099900|reactome:R-DME-5674135|reactome:R-DME-8856825|reactome:R-DME-8856828|ensemblmetazoa:FBgn0040206(gene)|ensemblmetazoa:FBtr0085877(transcript)|ensemblmetazoa:FBtr0305268(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0031648"(protein destabilization)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060189"(positive regulation of protein desumoylation)|go:"GO:0120177"(negative regulation of torso signaling pathway)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|mint:MINT-8075497(identity)	-	-	-	comment:mint|figure legend:sf6a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2010/11/26	2014/10/16	rogid:rbvsd7+5RvYrFoXyonEM6Li84hM7227	rogid:u4kgjQVpafnDKhPINoD7ftUYmNo7227	intact-crc:1E4749FCE15AD86B|rigid:9jACx3X1fWcCrhgpVv3J0SHNjxE	false	ha tag:?-?(MINT-8075494)	mutation increasing interaction:209-209(MINT-8075498)|green fluorescent protein tag:?-?(MINT-8075500)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P32121	uniprotkb:P40417	intact:EBI-714559|uniprotkb:Q0Z8D3|uniprotkb:Q2PP19|uniprotkb:Q6ICT3|uniprotkb:Q8N7Y2|uniprotkb:Q9UEQ6|uniprotkb:B7WPL3|uniprotkb:B5B0C0|uniprotkb:D3DTK2|intact:EBI-28974065|ensembl:ENSP00000269260|uniprotkb:B4DLW0|uniprotkb:H0Y688	intact:EBI-867790|uniprotkb:A0A021WW06|uniprotkb:Q7PL59|uniprotkb:Q9W5M2|uniprotkb:A8Y4W1|uniprotkb:A8Y4W2|uniprotkb:Q9W5M3|ensemblmetazoa:FBpp0112423|ensemblmetazoa:FBpp0112425|ensemblmetazoa:FBpp0112426|ensemblmetazoa:FBpp0311493	psi-mi:arrb2_human(display_long)|uniprotkb:Arrestin beta-2(gene name synonym)|uniprotkb:ARRB2(gene name)|psi-mi:ARRB2(display_short)|uniprotkb:ARB2(gene name synonym)|uniprotkb:ARR2(gene name synonym)|uniprotkb:Non-visual arrestin-3(gene name synonym)	psi-mi:erka_drome(display_long)|uniprotkb:Extracellular-regulated kinase A(gene name synonym)|uniprotkb:Protein rolled(gene name synonym)|uniprotkb:rl(gene name)|psi-mi:rl(display_short)|uniprotkb:ERKa(gene name synonym)|uniprotkb:CG12559(orf name)|uniprotkb:MAPK(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tipping et al. (2010)	pubmed:20802461|imex:IM-15196|mint:MINT-8075200|doi:10.1038/emboj.2010.202	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8179804|mint:MINT-8075507|imex:IM-15196-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000269260|ensembl:ENST00000346341|ensembl:ENSP00000341895|ensembl:ENST00000381488|ensembl:ENSP00000370898|ensembl:ENST00000412477|ensembl:ENSP00000403701|ensembl:ENSG00000141480(gene)|ensembl:ENST00000269260(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|interpro:IPR017864|go:"GO:0005634"(nucleus)|mint:P32121|reactome:R-HSA-2122948|reactome:R-HSA-418555|reactome:R-HSA-456926|reactome:R-HSA-5099900|reactome:R-HSA-5635838|reactome:R-HSA-5674135|reactome:R-HSA-5689880|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9649948|reactome:R-HSA-9656223|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031859"(platelet activating factor receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0005829"(cytosol)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0005886"(plasma membrane)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:0007212"(dopamine receptor signaling pathway)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|go:"GO:0007420"(brain development)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|go:"GO:0007628"(adult walking behavior)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|refseq:NP_004304.1|refseq:NP_945355.1|refseq:NP_001316993.1|refseq:NP_001244259.1|refseq:NP_001244260.1|refseq:NP_001244257.1|refseq:NP_001244258.1|dip:DIP-40089N|mint:MINT-8075509(identity)	refseq:NP_001015121.3|refseq:NP_001104348.2|refseq:NP_001287635.1|refseq:NP_001015122.1|refseq:NP_001015123.1|refseq:NP_001104349.1|flybase:FBgn0003256|dip:DIP-17266N|ensemblmetazoa:FBgn0003256(gene)|ensemblmetazoa:FBtr0113700(transcript)|ensemblmetazoa:FBtr0113702(transcript)|ensemblmetazoa:FBtr0113703(transcript)|ensemblmetazoa:FBtr0345337(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007362"(terminal region determination)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007479"(leg disc proximal/distal pattern formation)|go:"GO:0007552"(metamorphosis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035169"(lymph gland plasmatocyte differentiation)|go:"GO:0035170"(lymph gland crystal cell differentiation)|go:"GO:0035202"(tracheal pit formation in open tracheal system)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046534"(positive regulation of photoreceptor cell differentiation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000826"(regulation of heart morphogenesis)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P40417|reactome:R-DME-110056|reactome:R-DME-112409|reactome:R-DME-112411|reactome:R-DME-1295596|reactome:R-DME-162658|reactome:R-DME-170968|reactome:R-DME-198753|reactome:R-DME-202670|reactome:R-DME-2029482|reactome:R-DME-2559580|reactome:R-DME-2559582|reactome:R-DME-2559585|reactome:R-DME-2871796|reactome:R-DME-3371453|reactome:R-DME-375165|reactome:R-DME-437239|reactome:R-DME-445144|reactome:R-DME-450341|reactome:R-DME-456926|reactome:R-DME-5654726|reactome:R-DME-5654727|reactome:R-DME-5654732|reactome:R-DME-5654733|reactome:R-DME-5663213|reactome:R-DME-5673001|reactome:R-DME-5674135|reactome:R-DME-5674499|reactome:R-DME-5675221|reactome:R-DME-5687128|reactome:R-DME-6798695|reactome:R-DME-74749|reactome:R-DME-881907|reactome:R-DME-9634635|reactome:R-DME-9634638|mint:MINT-8075513(identity)	-	-	-	comment:homomint|figure legend:sf3|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2010/11/26	2014/10/16	rogid:MY34flMH9cdhPtMLGYOQtoQyr2U9606	rogid:m7w7KhuZSyx3t+dR2TKtvx/vRtA7227	intact-crc:CD7D39A26358C1E7|rigid:vT9+C2f73Y8UQ/FX+SYSKzuQ95M	false	ha tag:?-?(MINT-8075510)	mutation disrupting interaction:148-148(MINT-8075516)|flag tag:?-?(MINT-8075518)|mutation disrupting interaction:150-150(MINT-8075514)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P40417	uniprotkb:P32121	intact:EBI-867790|uniprotkb:A0A021WW06|uniprotkb:Q7PL59|uniprotkb:Q9W5M2|uniprotkb:A8Y4W1|uniprotkb:A8Y4W2|uniprotkb:Q9W5M3|ensemblmetazoa:FBpp0112423|ensemblmetazoa:FBpp0112425|ensemblmetazoa:FBpp0112426|ensemblmetazoa:FBpp0311493	intact:EBI-714559|uniprotkb:Q0Z8D3|uniprotkb:Q2PP19|uniprotkb:Q6ICT3|uniprotkb:Q8N7Y2|uniprotkb:Q9UEQ6|uniprotkb:B7WPL3|uniprotkb:B5B0C0|uniprotkb:D3DTK2|intact:EBI-28974065|ensembl:ENSP00000269260|uniprotkb:B4DLW0|uniprotkb:H0Y688	psi-mi:erka_drome(display_long)|uniprotkb:Extracellular-regulated kinase A(gene name synonym)|uniprotkb:Protein rolled(gene name synonym)|uniprotkb:rl(gene name)|psi-mi:rl(display_short)|uniprotkb:ERKa(gene name synonym)|uniprotkb:CG12559(orf name)|uniprotkb:MAPK(gene name synonym)	psi-mi:arrb2_human(display_long)|uniprotkb:Arrestin beta-2(gene name synonym)|uniprotkb:ARRB2(gene name)|psi-mi:ARRB2(display_short)|uniprotkb:ARB2(gene name synonym)|uniprotkb:ARR2(gene name synonym)|uniprotkb:Non-visual arrestin-3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tipping et al. (2010)	pubmed:20802461|imex:IM-15196|mint:MINT-8075200|doi:10.1038/emboj.2010.202	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8179830|mint:MINT-8075524|imex:IM-15196-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001015121.3|refseq:NP_001104348.2|refseq:NP_001287635.1|refseq:NP_001015122.1|refseq:NP_001015123.1|refseq:NP_001104349.1|flybase:FBgn0003256|dip:DIP-17266N|ensemblmetazoa:FBgn0003256(gene)|ensemblmetazoa:FBtr0113700(transcript)|ensemblmetazoa:FBtr0113702(transcript)|ensemblmetazoa:FBtr0113703(transcript)|ensemblmetazoa:FBtr0345337(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007362"(terminal region determination)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007479"(leg disc proximal/distal pattern formation)|go:"GO:0007552"(metamorphosis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035169"(lymph gland plasmatocyte differentiation)|go:"GO:0035170"(lymph gland crystal cell differentiation)|go:"GO:0035202"(tracheal pit formation in open tracheal system)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046534"(positive regulation of photoreceptor cell differentiation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000826"(regulation of heart morphogenesis)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P40417|reactome:R-DME-110056|reactome:R-DME-112409|reactome:R-DME-112411|reactome:R-DME-1295596|reactome:R-DME-162658|reactome:R-DME-170968|reactome:R-DME-198753|reactome:R-DME-202670|reactome:R-DME-2029482|reactome:R-DME-2559580|reactome:R-DME-2559582|reactome:R-DME-2559585|reactome:R-DME-2871796|reactome:R-DME-3371453|reactome:R-DME-375165|reactome:R-DME-437239|reactome:R-DME-445144|reactome:R-DME-450341|reactome:R-DME-456926|reactome:R-DME-5654726|reactome:R-DME-5654727|reactome:R-DME-5654732|reactome:R-DME-5654733|reactome:R-DME-5663213|reactome:R-DME-5673001|reactome:R-DME-5674135|reactome:R-DME-5674499|reactome:R-DME-5675221|reactome:R-DME-5687128|reactome:R-DME-6798695|reactome:R-DME-74749|reactome:R-DME-881907|reactome:R-DME-9634635|reactome:R-DME-9634638|mint:MINT-8075526(identity)	ensembl:ENSP00000269260|ensembl:ENST00000346341|ensembl:ENSP00000341895|ensembl:ENST00000381488|ensembl:ENSP00000370898|ensembl:ENST00000412477|ensembl:ENSP00000403701|ensembl:ENSG00000141480(gene)|ensembl:ENST00000269260(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|interpro:IPR017864|go:"GO:0005634"(nucleus)|mint:P32121|reactome:R-HSA-2122948|reactome:R-HSA-418555|reactome:R-HSA-456926|reactome:R-HSA-5099900|reactome:R-HSA-5635838|reactome:R-HSA-5674135|reactome:R-HSA-5689880|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9649948|reactome:R-HSA-9656223|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031859"(platelet activating factor receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0005829"(cytosol)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0005886"(plasma membrane)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:0007212"(dopamine receptor signaling pathway)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|go:"GO:0007420"(brain development)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|go:"GO:0007628"(adult walking behavior)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|refseq:NP_004304.1|refseq:NP_945355.1|refseq:NP_001316993.1|refseq:NP_001244259.1|refseq:NP_001244260.1|refseq:NP_001244257.1|refseq:NP_001244258.1|dip:DIP-40089N|mint:MINT-8075534(identity)	-	-	-	comment:homomint|figure legend:sf3|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2010/11/26	2014/10/16	rogid:m7w7KhuZSyx3t+dR2TKtvx/vRtA7227	rogid:MY34flMH9cdhPtMLGYOQtoQyr2U9606	intact-crc:ADE3887E35703477|rigid:vT9+C2f73Y8UQ/FX+SYSKzuQ95M	false	mutation decreasing interaction:150-150(MINT-8075531)|flag tag:?-?(MINT-8075527)	ha tag:?-?(MINT-8075535)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P32121	uniprotkb:P40417	intact:EBI-714559|uniprotkb:Q0Z8D3|uniprotkb:Q2PP19|uniprotkb:Q6ICT3|uniprotkb:Q8N7Y2|uniprotkb:Q9UEQ6|uniprotkb:B7WPL3|uniprotkb:B5B0C0|uniprotkb:D3DTK2|intact:EBI-28974065|ensembl:ENSP00000269260|uniprotkb:B4DLW0|uniprotkb:H0Y688	intact:EBI-867790|uniprotkb:A0A021WW06|uniprotkb:Q7PL59|uniprotkb:Q9W5M2|uniprotkb:A8Y4W1|uniprotkb:A8Y4W2|uniprotkb:Q9W5M3|ensemblmetazoa:FBpp0112423|ensemblmetazoa:FBpp0112425|ensemblmetazoa:FBpp0112426|ensemblmetazoa:FBpp0311493	psi-mi:arrb2_human(display_long)|uniprotkb:Arrestin beta-2(gene name synonym)|uniprotkb:ARRB2(gene name)|psi-mi:ARRB2(display_short)|uniprotkb:ARB2(gene name synonym)|uniprotkb:ARR2(gene name synonym)|uniprotkb:Non-visual arrestin-3(gene name synonym)	psi-mi:erka_drome(display_long)|uniprotkb:Extracellular-regulated kinase A(gene name synonym)|uniprotkb:Protein rolled(gene name synonym)|uniprotkb:rl(gene name)|psi-mi:rl(display_short)|uniprotkb:ERKa(gene name synonym)|uniprotkb:CG12559(orf name)|uniprotkb:MAPK(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tipping et al. (2010)	pubmed:20802461|imex:IM-15196|mint:MINT-8075200|doi:10.1038/emboj.2010.202	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8179852|mint:MINT-8075540|imex:IM-15196-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000269260|ensembl:ENST00000346341|ensembl:ENSP00000341895|ensembl:ENST00000381488|ensembl:ENSP00000370898|ensembl:ENST00000412477|ensembl:ENSP00000403701|ensembl:ENSG00000141480(gene)|ensembl:ENST00000269260(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|interpro:IPR017864|go:"GO:0005634"(nucleus)|mint:P32121|reactome:R-HSA-2122948|reactome:R-HSA-418555|reactome:R-HSA-456926|reactome:R-HSA-5099900|reactome:R-HSA-5635838|reactome:R-HSA-5674135|reactome:R-HSA-5689880|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9649948|reactome:R-HSA-9656223|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031859"(platelet activating factor receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0005829"(cytosol)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0005886"(plasma membrane)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:0007212"(dopamine receptor signaling pathway)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|go:"GO:0007420"(brain development)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|go:"GO:0007628"(adult walking behavior)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|refseq:NP_004304.1|refseq:NP_945355.1|refseq:NP_001316993.1|refseq:NP_001244259.1|refseq:NP_001244260.1|refseq:NP_001244257.1|refseq:NP_001244258.1|dip:DIP-40089N|mint:MINT-8075548(identity)	refseq:NP_001015121.3|refseq:NP_001104348.2|refseq:NP_001287635.1|refseq:NP_001015122.1|refseq:NP_001015123.1|refseq:NP_001104349.1|flybase:FBgn0003256|dip:DIP-17266N|ensemblmetazoa:FBgn0003256(gene)|ensemblmetazoa:FBtr0113700(transcript)|ensemblmetazoa:FBtr0113702(transcript)|ensemblmetazoa:FBtr0113703(transcript)|ensemblmetazoa:FBtr0345337(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007362"(terminal region determination)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007479"(leg disc proximal/distal pattern formation)|go:"GO:0007552"(metamorphosis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035169"(lymph gland plasmatocyte differentiation)|go:"GO:0035170"(lymph gland crystal cell differentiation)|go:"GO:0035202"(tracheal pit formation in open tracheal system)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046534"(positive regulation of photoreceptor cell differentiation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000826"(regulation of heart morphogenesis)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P40417|reactome:R-DME-110056|reactome:R-DME-112409|reactome:R-DME-112411|reactome:R-DME-1295596|reactome:R-DME-162658|reactome:R-DME-170968|reactome:R-DME-198753|reactome:R-DME-202670|reactome:R-DME-2029482|reactome:R-DME-2559580|reactome:R-DME-2559582|reactome:R-DME-2559585|reactome:R-DME-2871796|reactome:R-DME-3371453|reactome:R-DME-375165|reactome:R-DME-437239|reactome:R-DME-445144|reactome:R-DME-450341|reactome:R-DME-456926|reactome:R-DME-5654726|reactome:R-DME-5654727|reactome:R-DME-5654732|reactome:R-DME-5654733|reactome:R-DME-5663213|reactome:R-DME-5673001|reactome:R-DME-5674135|reactome:R-DME-5674499|reactome:R-DME-5675221|reactome:R-DME-5687128|reactome:R-DME-6798695|reactome:R-DME-74749|reactome:R-DME-881907|reactome:R-DME-9634635|reactome:R-DME-9634638|mint:MINT-8075542(identity)	-	-	-	comment:homomint|figure legend:sf3|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2010/11/26	2014/10/16	rogid:MY34flMH9cdhPtMLGYOQtoQyr2U9606	rogid:m7w7KhuZSyx3t+dR2TKtvx/vRtA7227	intact-crc:CD2C95BB1ED21EA4|rigid:vT9+C2f73Y8UQ/FX+SYSKzuQ95M	false	ha tag:?-?(MINT-8075549)	mutation decreasing interaction:148-148(MINT-8075543)|flag tag:?-?(MINT-8075545)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P40417	uniprotkb:P32121	intact:EBI-867790|uniprotkb:A0A021WW06|uniprotkb:Q7PL59|uniprotkb:Q9W5M2|uniprotkb:A8Y4W1|uniprotkb:A8Y4W2|uniprotkb:Q9W5M3|ensemblmetazoa:FBpp0112423|ensemblmetazoa:FBpp0112425|ensemblmetazoa:FBpp0112426|ensemblmetazoa:FBpp0311493	intact:EBI-714559|uniprotkb:Q0Z8D3|uniprotkb:Q2PP19|uniprotkb:Q6ICT3|uniprotkb:Q8N7Y2|uniprotkb:Q9UEQ6|uniprotkb:B7WPL3|uniprotkb:B5B0C0|uniprotkb:D3DTK2|intact:EBI-28974065|ensembl:ENSP00000269260|uniprotkb:B4DLW0|uniprotkb:H0Y688	psi-mi:erka_drome(display_long)|uniprotkb:Extracellular-regulated kinase A(gene name synonym)|uniprotkb:Protein rolled(gene name synonym)|uniprotkb:rl(gene name)|psi-mi:rl(display_short)|uniprotkb:ERKa(gene name synonym)|uniprotkb:CG12559(orf name)|uniprotkb:MAPK(gene name synonym)	psi-mi:arrb2_human(display_long)|uniprotkb:Arrestin beta-2(gene name synonym)|uniprotkb:ARRB2(gene name)|psi-mi:ARRB2(display_short)|uniprotkb:ARB2(gene name synonym)|uniprotkb:ARR2(gene name synonym)|uniprotkb:Non-visual arrestin-3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tipping et al. (2010)	pubmed:20802461|imex:IM-15196|mint:MINT-8075200|doi:10.1038/emboj.2010.202	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8179903|mint:MINT-8075555|imex:IM-15196-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001015121.3|refseq:NP_001104348.2|refseq:NP_001287635.1|refseq:NP_001015122.1|refseq:NP_001015123.1|refseq:NP_001104349.1|flybase:FBgn0003256|dip:DIP-17266N|ensemblmetazoa:FBgn0003256(gene)|ensemblmetazoa:FBtr0113700(transcript)|ensemblmetazoa:FBtr0113702(transcript)|ensemblmetazoa:FBtr0113703(transcript)|ensemblmetazoa:FBtr0345337(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007362"(terminal region determination)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007479"(leg disc proximal/distal pattern formation)|go:"GO:0007552"(metamorphosis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035169"(lymph gland plasmatocyte differentiation)|go:"GO:0035170"(lymph gland crystal cell differentiation)|go:"GO:0035202"(tracheal pit formation in open tracheal system)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046534"(positive regulation of photoreceptor cell differentiation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000826"(regulation of heart morphogenesis)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P40417|reactome:R-DME-110056|reactome:R-DME-112409|reactome:R-DME-112411|reactome:R-DME-1295596|reactome:R-DME-162658|reactome:R-DME-170968|reactome:R-DME-198753|reactome:R-DME-202670|reactome:R-DME-2029482|reactome:R-DME-2559580|reactome:R-DME-2559582|reactome:R-DME-2559585|reactome:R-DME-2871796|reactome:R-DME-3371453|reactome:R-DME-375165|reactome:R-DME-437239|reactome:R-DME-445144|reactome:R-DME-450341|reactome:R-DME-456926|reactome:R-DME-5654726|reactome:R-DME-5654727|reactome:R-DME-5654732|reactome:R-DME-5654733|reactome:R-DME-5663213|reactome:R-DME-5673001|reactome:R-DME-5674135|reactome:R-DME-5674499|reactome:R-DME-5675221|reactome:R-DME-5687128|reactome:R-DME-6798695|reactome:R-DME-74749|reactome:R-DME-881907|reactome:R-DME-9634635|reactome:R-DME-9634638|mint:MINT-8075557(identity)	ensembl:ENSP00000269260|ensembl:ENST00000346341|ensembl:ENSP00000341895|ensembl:ENST00000381488|ensembl:ENSP00000370898|ensembl:ENST00000412477|ensembl:ENSP00000403701|ensembl:ENSG00000141480(gene)|ensembl:ENST00000269260(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|interpro:IPR017864|go:"GO:0005634"(nucleus)|mint:P32121|reactome:R-HSA-2122948|reactome:R-HSA-418555|reactome:R-HSA-456926|reactome:R-HSA-5099900|reactome:R-HSA-5635838|reactome:R-HSA-5674135|reactome:R-HSA-5689880|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9649948|reactome:R-HSA-9656223|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031859"(platelet activating factor receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0005829"(cytosol)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0005886"(plasma membrane)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:0007212"(dopamine receptor signaling pathway)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|go:"GO:0007420"(brain development)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|go:"GO:0007628"(adult walking behavior)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|refseq:NP_004304.1|refseq:NP_945355.1|refseq:NP_001316993.1|refseq:NP_001244259.1|refseq:NP_001244260.1|refseq:NP_001244257.1|refseq:NP_001244258.1|dip:DIP-40089N|mint:MINT-8075563(identity)	-	-	-	comment:homomint|figure legend:sf3|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2010/11/26	2014/10/16	rogid:m7w7KhuZSyx3t+dR2TKtvx/vRtA7227	rogid:MY34flMH9cdhPtMLGYOQtoQyr2U9606	intact-crc:B877ADE37F6A582B|rigid:vT9+C2f73Y8UQ/FX+SYSKzuQ95M	false	flag tag:?-?(MINT-8075558)	ha tag:?-?(MINT-8075564)|mutation increasing interaction:170-170(MINT-8075568)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9V393	uniprotkb:Q03017	intact:EBI-100228|ensemblmetazoa:FBpp0085236|ensemblmetazoa:FBpp0293792	intact:EBI-200600|uniprotkb:A4V0S3|uniprotkb:Q0E8Q3|uniprotkb:Q9V3M6|ensemblmetazoa:FBpp0080402|ensemblmetazoa:FBpp0080403|ensemblmetazoa:FBpp0089296|ensemblmetazoa:FBpp0308004	psi-mi:q9v393_drome(display_long)|uniprotkb:krz(gene name)|psi-mi:krz(display_short)|uniprotkb:CG1487(orf name)|uniprotkb:0952(gene name synonym)|uniprotkb:14(gene name synonym)|uniprotkb:Dmel\CG1487(gene name synonym)|uniprotkb:Krz(gene name synonym)|uniprotkb:Kurz(gene name synonym)|uniprotkb:"l(3)S095214"(gene name synonym)|uniprotkb:Dmel_CG1487(orf name)|uniprotkb:beta-arr2(gene name synonym)	psi-mi:cact_drome(display_long)|uniprotkb:CG5848(orf name)|uniprotkb:cact(gene name)|psi-mi:cact(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tipping et al. (2010)	pubmed:20802461|imex:IM-15196|mint:MINT-8075200|doi:10.1038/emboj.2010.202	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8179965|mint:MINT-8075446|imex:IM-15196-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524988.1|flybase:FBgn0040206|refseq:NP_001247400.1|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|reactome:R-DME-432720|reactome:R-DME-432722|reactome:R-DME-456926|reactome:R-DME-5099900|reactome:R-DME-5674135|reactome:R-DME-8856825|reactome:R-DME-8856828|ensemblmetazoa:FBgn0040206(gene)|ensemblmetazoa:FBtr0085877(transcript)|ensemblmetazoa:FBtr0305268(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0031648"(protein destabilization)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060189"(positive regulation of protein desumoylation)|go:"GO:0120177"(negative regulation of torso signaling pathway)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|mint:MINT-8075452(identity)	refseq:NP_476942.1|refseq:NP_476943.1|refseq:NP_723960.1|refseq:NP_995721.1|flybase:FBgn0000250|refseq:NP_001260496.1|dip:DIP-17846N|ensemblmetazoa:FBgn0000250(gene)|ensemblmetazoa:FBtr0080844(transcript)|ensemblmetazoa:FBtr0080845(transcript)|ensemblmetazoa:FBtr0080847(transcript)|ensemblmetazoa:FBtr0337081(transcript)|go:"GO:0002789"(negative regulation of antifungal peptide production)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007399"(nervous system development)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019730"(antimicrobial humoral response)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0045611"(negative regulation of hemocyte differentiation)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048477"(oogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0071212"(subsynaptic reticulum)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|reactome:R-DME-1169091|reactome:R-DME-202424|reactome:R-DME-209406|reactome:R-DME-209560|reactome:R-DME-214842|reactome:R-DME-214844|reactome:R-DME-214869|reactome:R-DME-2871837|reactome:R-DME-445989|reactome:R-DME-5607764|reactome:R-DME-9020702|mint:MINT-8075448(identity)	-	-	-	comment:mint|figure legend:sf7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/11/26	2014/10/16	rogid:u4kgjQVpafnDKhPINoD7ftUYmNo7227	rogid:xVqWiRJtkb1WDO5GmztYwgdB9iI7227	intact-crc:1F196882F9852B8B|rigid:spjkbmCfogYcGD5JNXAiMMYYNsI	false	ha tag:?-?(MINT-8075453)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9V393	uniprotkb:P40417	intact:EBI-100228|ensemblmetazoa:FBpp0085236|ensemblmetazoa:FBpp0293792	intact:EBI-867790|uniprotkb:A0A021WW06|uniprotkb:Q7PL59|uniprotkb:Q9W5M2|uniprotkb:A8Y4W1|uniprotkb:A8Y4W2|uniprotkb:Q9W5M3|ensemblmetazoa:FBpp0112423|ensemblmetazoa:FBpp0112425|ensemblmetazoa:FBpp0112426|ensemblmetazoa:FBpp0311493	psi-mi:q9v393_drome(display_long)|uniprotkb:krz(gene name)|psi-mi:krz(display_short)|uniprotkb:CG1487(orf name)|uniprotkb:0952(gene name synonym)|uniprotkb:14(gene name synonym)|uniprotkb:Dmel\CG1487(gene name synonym)|uniprotkb:Krz(gene name synonym)|uniprotkb:Kurz(gene name synonym)|uniprotkb:"l(3)S095214"(gene name synonym)|uniprotkb:Dmel_CG1487(orf name)|uniprotkb:beta-arr2(gene name synonym)	psi-mi:erka_drome(display_long)|uniprotkb:Extracellular-regulated kinase A(gene name synonym)|uniprotkb:Protein rolled(gene name synonym)|uniprotkb:rl(gene name)|psi-mi:rl(display_short)|uniprotkb:ERKa(gene name synonym)|uniprotkb:CG12559(orf name)|uniprotkb:MAPK(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tipping et al. (2010)	pubmed:20802461|imex:IM-15196|mint:MINT-8075200|doi:10.1038/emboj.2010.202	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8179994|mint:MINT-8081189|imex:IM-15196-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524988.1|flybase:FBgn0040206|refseq:NP_001247400.1|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|reactome:R-DME-432720|reactome:R-DME-432722|reactome:R-DME-456926|reactome:R-DME-5099900|reactome:R-DME-5674135|reactome:R-DME-8856825|reactome:R-DME-8856828|ensemblmetazoa:FBgn0040206(gene)|ensemblmetazoa:FBtr0085877(transcript)|ensemblmetazoa:FBtr0305268(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0031648"(protein destabilization)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060189"(positive regulation of protein desumoylation)|go:"GO:0120177"(negative regulation of torso signaling pathway)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|mint:MINT-8081193(identity)	refseq:NP_001015121.3|refseq:NP_001104348.2|refseq:NP_001287635.1|refseq:NP_001015122.1|refseq:NP_001015123.1|refseq:NP_001104349.1|flybase:FBgn0003256|dip:DIP-17266N|ensemblmetazoa:FBgn0003256(gene)|ensemblmetazoa:FBtr0113700(transcript)|ensemblmetazoa:FBtr0113702(transcript)|ensemblmetazoa:FBtr0113703(transcript)|ensemblmetazoa:FBtr0345337(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007362"(terminal region determination)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007479"(leg disc proximal/distal pattern formation)|go:"GO:0007552"(metamorphosis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035169"(lymph gland plasmatocyte differentiation)|go:"GO:0035170"(lymph gland crystal cell differentiation)|go:"GO:0035202"(tracheal pit formation in open tracheal system)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046534"(positive regulation of photoreceptor cell differentiation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000826"(regulation of heart morphogenesis)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P40417|reactome:R-DME-110056|reactome:R-DME-112409|reactome:R-DME-112411|reactome:R-DME-1295596|reactome:R-DME-162658|reactome:R-DME-170968|reactome:R-DME-198753|reactome:R-DME-202670|reactome:R-DME-2029482|reactome:R-DME-2559580|reactome:R-DME-2559582|reactome:R-DME-2559585|reactome:R-DME-2871796|reactome:R-DME-3371453|reactome:R-DME-375165|reactome:R-DME-437239|reactome:R-DME-445144|reactome:R-DME-450341|reactome:R-DME-456926|reactome:R-DME-5654726|reactome:R-DME-5654727|reactome:R-DME-5654732|reactome:R-DME-5654733|reactome:R-DME-5663213|reactome:R-DME-5673001|reactome:R-DME-5674135|reactome:R-DME-5674499|reactome:R-DME-5675221|reactome:R-DME-5687128|reactome:R-DME-6798695|reactome:R-DME-74749|reactome:R-DME-881907|reactome:R-DME-9634635|reactome:R-DME-9634638|mint:MINT-8081191(identity)	-	-	-	comment:mint|figure legend:sf4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/11/26	2014/10/16	rogid:u4kgjQVpafnDKhPINoD7ftUYmNo7227	rogid:m7w7KhuZSyx3t+dR2TKtvx/vRtA7227	intact-crc:57E48198E0AE4F90|rigid:P0vKsKAmH2zoNQ06UZj7BYKQqFk	false	ha tag:?-?(MINT-8081194)	flag tag:?-?(MINT-8081199)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)