#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q01083	uniprotkb:P04412	intact:EBI-91342|ensemblmetazoa:FBpp0080808|ensemblmetazoa:FBpp0080809|ensemblmetazoa:FBpp0080810|ensemblmetazoa:FBpp0080811|ensemblmetazoa:FBpp0100054|uniprotkb:Q8SXE0|uniprotkb:Q9VIT4	intact:EBI-197863|uniprotkb:O18370|uniprotkb:O61601|uniprotkb:P81868|uniprotkb:Q9W2G0|ensemblmetazoa:FBpp0071571	psi-mi:spitz_drome(display_long)|uniprotkb:spi(gene name)|psi-mi:spi(display_short)|uniprotkb:CG10334(orf name)	psi-mi:egfr_drome(display_long)|uniprotkb:Egfr(gene name)|psi-mi:Egfr(display_short)|uniprotkb:top(gene name synonym)|uniprotkb:DER(gene name synonym)|uniprotkb:c-erbB(gene name synonym)|uniprotkb:CG10079(orf name)|uniprotkb:Gurken receptor(gene name synonym)|uniprotkb:Protein torpedo(gene name synonym)|uniprotkb:Drosophila relative of ERBB(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Alvarado et al. (2010)	imex:IM-14974|pubmed:20723758	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2911638|wwpdb:3ltf|imex:IM-14974-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005789"(endoplasmic reticulum membrane)|ensemblmetazoa:FBgn0005672(gene)|ensemblmetazoa:FBtr0081267(transcript)|ensemblmetazoa:FBtr0081268(transcript)|ensemblmetazoa:FBtr0081269(transcript)|ensemblmetazoa:FBtr0081270(transcript)|ensemblmetazoa:FBtr0100597(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001713"(ectodermal cell fate determination)|go:"GO:0003015"(heart process)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|refseq:NP_001027281.1|refseq:NP_476909.2|refseq:NP_599118.2|refseq:NP_599119.2|refseq:NP_599120.2|flybase:FBgn0005672|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007391"(dorsal closure)|go:"GO:0007421"(stomatogastric nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007438"(oenocyte development)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008355"(olfactory learning)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016318"(ommatidial rotation)|go:"GO:0035225"(determination of genital disc primordium)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043703"(photoreceptor cell fate determination)|go:"GO:0046530"(photoreceptor cell differentiation)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048865"(stem cell fate commitment)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061331"(epithelial cell proliferation involved in Malpighian tubule morphogenesis)|go:"GO:1903688"(positive regulation of border follicle cell migration)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR043403|rcsb pdb:3C9A|rcsb pdb:3CA7|rcsb pdb:3LTF|rcsb pdb:3LTG|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|dip:DIP-18037N	refseq:NP_476759.1|flybase:FBgn0003731|dip:DIP-17316N|ensemblmetazoa:FBgn0003731(gene)|ensemblmetazoa:FBtr0071654(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001742"(oenocyte differentiation)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0003015"(heart process)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007309"(oocyte axis specification)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007390"(germ-band shortening)|go:"GO:0007391"(dorsal closure)|go:"GO:0007395"(dorsal closure, spreading of leading edge cells)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007426"(tracheal outgrowth, open tracheal system)|go:"GO:0007431"(salivary gland development)|go:"GO:0007443"(Malpighian tubule morphogenesis)|go:"GO:0007444"(imaginal disc development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007472"(wing disc morphogenesis)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007477"(notum development)|go:"GO:0007479"(leg disc proximal/distal pattern formation)|go:"GO:0007482"(haltere development)|go:"GO:0008071"(maternal determination of dorsal/ventral axis, ovarian follicular epithelium, soma encoded)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008355"(olfactory learning)|go:"GO:0008406"(gonad development)|go:"GO:0008586"(imaginal disc-derived wing vein morphogenesis)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016318"(ommatidial rotation)|go:"GO:0016330"(second mitotic wave involved in compound eye morphogenesis)|go:"GO:0016333"(morphogenesis of follicular epithelium)|go:"GO:0022008"(neurogenesis)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030381"(chorion-containing eggshell pattern formation)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0035149"(lumen formation, open tracheal system)|go:"GO:0035159"(regulation of tube length, open tracheal system)|go:"GO:0035160"(maintenance of epithelial integrity, open tracheal system)|go:"GO:0035225"(determination of genital disc primordium)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035309"(wing and notum subfield formation)|go:"GO:0035310"(notum cell fate specification)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042675"(compound eye cone cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043703"(photoreceptor cell fate determination)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0046530"(photoreceptor cell differentiation)|go:"GO:0046673"(negative regulation of compound eye retinal cell programmed cell death)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0048749"(compound eye development)|go:"GO:0048865"(stem cell fate commitment)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0061331"(epithelial cell proliferation involved in Malpighian tubule morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P04412|rcsb pdb:3I2T|rcsb pdb:3LTF|rcsb pdb:3LTG|reactome:R-DME-1227986|reactome:R-DME-1250196|reactome:R-DME-1251985|reactome:R-DME-1253288|reactome:R-DME-1257604|reactome:R-DME-1358803|reactome:R-DME-177929|reactome:R-DME-179812|reactome:R-DME-180292|reactome:R-DME-180336|reactome:R-DME-182971|reactome:R-DME-1963642|reactome:R-DME-212718|reactome:R-DME-2179392|reactome:R-DME-416572|reactome:R-DME-5673001|reactome:R-DME-6785631|reactome:R-DME-6811558|reactome:R-DME-8856825|reactome:R-DME-8856828|reactome:R-DME-8863795|reactome:R-DME-9018519|reactome:R-DME-9652282	-	-	-	3d-r-factors:"R-working:23.664% R-free:27.542%"|3d-resolution:3.2A|figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	rogid:RO8D5JspHbtNUFx11JHFCoUuv0A7227	rogid:Ae9kedh1v+TZ5zG4QorNPm9/FgA7227	intact-crc:D3EE32CC055FC3BC|rigid:x8ujv6G5KzGfNLeJgOtgQrj/A+A	false	sufficient binding region:76-133(IPR006209)	sufficient binding region:100-668|his tag:c-c	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04412	uniprotkb:Q01083	intact:EBI-197863|uniprotkb:O18370|uniprotkb:O61601|uniprotkb:P81868|uniprotkb:Q9W2G0|ensemblmetazoa:FBpp0071571	intact:EBI-91342|ensemblmetazoa:FBpp0080808|ensemblmetazoa:FBpp0080809|ensemblmetazoa:FBpp0080810|ensemblmetazoa:FBpp0080811|ensemblmetazoa:FBpp0100054|uniprotkb:Q8SXE0|uniprotkb:Q9VIT4	psi-mi:egfr_drome(display_long)|uniprotkb:Egfr(gene name)|psi-mi:Egfr(display_short)|uniprotkb:top(gene name synonym)|uniprotkb:DER(gene name synonym)|uniprotkb:c-erbB(gene name synonym)|uniprotkb:CG10079(orf name)|uniprotkb:Gurken receptor(gene name synonym)|uniprotkb:Protein torpedo(gene name synonym)|uniprotkb:Drosophila relative of ERBB(gene name synonym)	psi-mi:spitz_drome(display_long)|uniprotkb:spi(gene name)|psi-mi:spi(display_short)|uniprotkb:CG10334(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Alvarado et al. (2010)	imex:IM-14974|pubmed:20723758	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2911652|wwpdb:3ltg|imex:IM-14974-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_476759.1|flybase:FBgn0003731|dip:DIP-17316N|ensemblmetazoa:FBgn0003731(gene)|ensemblmetazoa:FBtr0071654(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001742"(oenocyte differentiation)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0003015"(heart process)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007309"(oocyte axis specification)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007390"(germ-band shortening)|go:"GO:0007391"(dorsal closure)|go:"GO:0007395"(dorsal closure, spreading of leading edge cells)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007426"(tracheal outgrowth, open tracheal system)|go:"GO:0007431"(salivary gland development)|go:"GO:0007443"(Malpighian tubule morphogenesis)|go:"GO:0007444"(imaginal disc development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007472"(wing disc morphogenesis)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007477"(notum development)|go:"GO:0007479"(leg disc proximal/distal pattern formation)|go:"GO:0007482"(haltere development)|go:"GO:0008071"(maternal determination of dorsal/ventral axis, ovarian follicular epithelium, soma encoded)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008355"(olfactory learning)|go:"GO:0008406"(gonad development)|go:"GO:0008586"(imaginal disc-derived wing vein morphogenesis)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016318"(ommatidial rotation)|go:"GO:0016330"(second mitotic wave involved in compound eye morphogenesis)|go:"GO:0016333"(morphogenesis of follicular epithelium)|go:"GO:0022008"(neurogenesis)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030381"(chorion-containing eggshell pattern formation)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0035149"(lumen formation, open tracheal system)|go:"GO:0035159"(regulation of tube length, open tracheal system)|go:"GO:0035160"(maintenance of epithelial integrity, open tracheal system)|go:"GO:0035225"(determination of genital disc primordium)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035309"(wing and notum subfield formation)|go:"GO:0035310"(notum cell fate specification)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042675"(compound eye cone cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043703"(photoreceptor cell fate determination)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0046530"(photoreceptor cell differentiation)|go:"GO:0046673"(negative regulation of compound eye retinal cell programmed cell death)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0048749"(compound eye development)|go:"GO:0048865"(stem cell fate commitment)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0061331"(epithelial cell proliferation involved in Malpighian tubule morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P04412|rcsb pdb:3I2T|rcsb pdb:3LTF|rcsb pdb:3LTG|reactome:R-DME-1227986|reactome:R-DME-1250196|reactome:R-DME-1251985|reactome:R-DME-1253288|reactome:R-DME-1257604|reactome:R-DME-1358803|reactome:R-DME-177929|reactome:R-DME-179812|reactome:R-DME-180292|reactome:R-DME-180336|reactome:R-DME-182971|reactome:R-DME-1963642|reactome:R-DME-212718|reactome:R-DME-2179392|reactome:R-DME-416572|reactome:R-DME-5673001|reactome:R-DME-6785631|reactome:R-DME-6811558|reactome:R-DME-8856825|reactome:R-DME-8856828|reactome:R-DME-8863795|reactome:R-DME-9018519|reactome:R-DME-9652282	go:"GO:0005789"(endoplasmic reticulum membrane)|ensemblmetazoa:FBgn0005672(gene)|ensemblmetazoa:FBtr0081267(transcript)|ensemblmetazoa:FBtr0081268(transcript)|ensemblmetazoa:FBtr0081269(transcript)|ensemblmetazoa:FBtr0081270(transcript)|ensemblmetazoa:FBtr0100597(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001713"(ectodermal cell fate determination)|go:"GO:0003015"(heart process)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|refseq:NP_001027281.1|refseq:NP_476909.2|refseq:NP_599118.2|refseq:NP_599119.2|refseq:NP_599120.2|flybase:FBgn0005672|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007391"(dorsal closure)|go:"GO:0007421"(stomatogastric nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007438"(oenocyte development)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008355"(olfactory learning)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016318"(ommatidial rotation)|go:"GO:0035225"(determination of genital disc primordium)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043703"(photoreceptor cell fate determination)|go:"GO:0046530"(photoreceptor cell differentiation)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048865"(stem cell fate commitment)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061331"(epithelial cell proliferation involved in Malpighian tubule morphogenesis)|go:"GO:1903688"(positive regulation of border follicle cell migration)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR043403|rcsb pdb:3C9A|rcsb pdb:3CA7|rcsb pdb:3LTF|rcsb pdb:3LTG|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|dip:DIP-18037N	-	-	-	3d-r-factors:"R-working:40.558% R-free:42.675%"|3d-resolution:3.4A|figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	rogid:Ae9kedh1v+TZ5zG4QorNPm9/FgA7227	rogid:RO8D5JspHbtNUFx11JHFCoUuv0A7227	intact-crc:FEF092921554C52F|rigid:x8ujv6G5KzGfNLeJgOtgQrj/A+A	false	sufficient binding region:100-668|his tag:c-c	sufficient binding region:76-126(IPR006209)	2	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04412	uniprotkb:Q01083	intact:EBI-197863|uniprotkb:O18370|uniprotkb:O61601|uniprotkb:P81868|uniprotkb:Q9W2G0|ensemblmetazoa:FBpp0071571	intact:EBI-91342|ensemblmetazoa:FBpp0080808|ensemblmetazoa:FBpp0080809|ensemblmetazoa:FBpp0080810|ensemblmetazoa:FBpp0080811|ensemblmetazoa:FBpp0100054|uniprotkb:Q8SXE0|uniprotkb:Q9VIT4	psi-mi:egfr_drome(display_long)|uniprotkb:Egfr(gene name)|psi-mi:Egfr(display_short)|uniprotkb:top(gene name synonym)|uniprotkb:DER(gene name synonym)|uniprotkb:c-erbB(gene name synonym)|uniprotkb:CG10079(orf name)|uniprotkb:Gurken receptor(gene name synonym)|uniprotkb:Protein torpedo(gene name synonym)|uniprotkb:Drosophila relative of ERBB(gene name synonym)	psi-mi:spitz_drome(display_long)|uniprotkb:spi(gene name)|psi-mi:spi(display_short)|uniprotkb:CG10334(orf name)	psi-mi:"MI:0892"(solid phase assay)	Alvarado et al. (2010)	imex:IM-14974|pubmed:20723758	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2911677|imex:IM-14974-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_476759.1|flybase:FBgn0003731|dip:DIP-17316N|ensemblmetazoa:FBgn0003731(gene)|ensemblmetazoa:FBtr0071654(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001742"(oenocyte differentiation)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0003015"(heart process)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007309"(oocyte axis specification)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007390"(germ-band shortening)|go:"GO:0007391"(dorsal closure)|go:"GO:0007395"(dorsal closure, spreading of leading edge cells)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007426"(tracheal outgrowth, open tracheal system)|go:"GO:0007431"(salivary gland development)|go:"GO:0007443"(Malpighian tubule morphogenesis)|go:"GO:0007444"(imaginal disc development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007472"(wing disc morphogenesis)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007477"(notum development)|go:"GO:0007479"(leg disc proximal/distal pattern formation)|go:"GO:0007482"(haltere development)|go:"GO:0008071"(maternal determination of dorsal/ventral axis, ovarian follicular epithelium, soma encoded)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008355"(olfactory learning)|go:"GO:0008406"(gonad development)|go:"GO:0008586"(imaginal disc-derived wing vein morphogenesis)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016318"(ommatidial rotation)|go:"GO:0016330"(second mitotic wave involved in compound eye morphogenesis)|go:"GO:0016333"(morphogenesis of follicular epithelium)|go:"GO:0022008"(neurogenesis)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030381"(chorion-containing eggshell pattern formation)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0035149"(lumen formation, open tracheal system)|go:"GO:0035159"(regulation of tube length, open tracheal system)|go:"GO:0035160"(maintenance of epithelial integrity, open tracheal system)|go:"GO:0035225"(determination of genital disc primordium)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035309"(wing and notum subfield formation)|go:"GO:0035310"(notum cell fate specification)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042675"(compound eye cone cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043703"(photoreceptor cell fate determination)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0046530"(photoreceptor cell differentiation)|go:"GO:0046673"(negative regulation of compound eye retinal cell programmed cell death)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0048749"(compound eye development)|go:"GO:0048865"(stem cell fate commitment)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0061331"(epithelial cell proliferation involved in Malpighian tubule morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P04412|rcsb pdb:3I2T|rcsb pdb:3LTF|rcsb pdb:3LTG|reactome:R-DME-1227986|reactome:R-DME-1250196|reactome:R-DME-1251985|reactome:R-DME-1253288|reactome:R-DME-1257604|reactome:R-DME-1358803|reactome:R-DME-177929|reactome:R-DME-179812|reactome:R-DME-180292|reactome:R-DME-180336|reactome:R-DME-182971|reactome:R-DME-1963642|reactome:R-DME-212718|reactome:R-DME-2179392|reactome:R-DME-416572|reactome:R-DME-5673001|reactome:R-DME-6785631|reactome:R-DME-6811558|reactome:R-DME-8856825|reactome:R-DME-8856828|reactome:R-DME-8863795|reactome:R-DME-9018519|reactome:R-DME-9652282	go:"GO:0005789"(endoplasmic reticulum membrane)|ensemblmetazoa:FBgn0005672(gene)|ensemblmetazoa:FBtr0081267(transcript)|ensemblmetazoa:FBtr0081268(transcript)|ensemblmetazoa:FBtr0081269(transcript)|ensemblmetazoa:FBtr0081270(transcript)|ensemblmetazoa:FBtr0100597(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001713"(ectodermal cell fate determination)|go:"GO:0003015"(heart process)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|refseq:NP_001027281.1|refseq:NP_476909.2|refseq:NP_599118.2|refseq:NP_599119.2|refseq:NP_599120.2|flybase:FBgn0005672|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007391"(dorsal closure)|go:"GO:0007421"(stomatogastric nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007438"(oenocyte development)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008355"(olfactory learning)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016318"(ommatidial rotation)|go:"GO:0035225"(determination of genital disc primordium)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043703"(photoreceptor cell fate determination)|go:"GO:0046530"(photoreceptor cell differentiation)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048865"(stem cell fate commitment)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061331"(epithelial cell proliferation involved in Malpighian tubule morphogenesis)|go:"GO:1903688"(positive regulation of border follicle cell migration)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR043403|rcsb pdb:3C9A|rcsb pdb:3CA7|rcsb pdb:3LTF|rcsb pdb:3LTG|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|dip:DIP-18037N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3|kinetics:"Hill coefficient (nH) = 0.31"|comment:"The Hill coefficient suggests negatively cooperative ligand binding. Wild-type proteins have a 2:2 stoichiometry, the dim-arm mutant prevents EGFR dimerization and results in no cooperativity of ligand binding."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	rogid:Ae9kedh1v+TZ5zG4QorNPm9/FgA7227	rogid:RO8D5JspHbtNUFx11JHFCoUuv0A7227	intact-crc:6F2FF2B30F690C8C|rigid:x8ujv6G5KzGfNLeJgOtgQrj/A+A	false	sufficient binding region:100-668|biotin tag:?-?|mutation decreasing interaction:346-348,344-344,341-342|tag:c-c|his tag:c-c	sufficient binding region:76-133(IPR006209)|alexa 488 label:?-?	2	2	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P04412	uniprotkb:Q01083	intact:EBI-197863|uniprotkb:O18370|uniprotkb:O61601|uniprotkb:P81868|uniprotkb:Q9W2G0|ensemblmetazoa:FBpp0071571	intact:EBI-91342|ensemblmetazoa:FBpp0080808|ensemblmetazoa:FBpp0080809|ensemblmetazoa:FBpp0080810|ensemblmetazoa:FBpp0080811|ensemblmetazoa:FBpp0100054|uniprotkb:Q8SXE0|uniprotkb:Q9VIT4	psi-mi:egfr_drome(display_long)|uniprotkb:Egfr(gene name)|psi-mi:Egfr(display_short)|uniprotkb:top(gene name synonym)|uniprotkb:DER(gene name synonym)|uniprotkb:c-erbB(gene name synonym)|uniprotkb:CG10079(orf name)|uniprotkb:Gurken receptor(gene name synonym)|uniprotkb:Protein torpedo(gene name synonym)|uniprotkb:Drosophila relative of ERBB(gene name synonym)	psi-mi:spitz_drome(display_long)|uniprotkb:spi(gene name)|psi-mi:spi(display_short)|uniprotkb:CG10334(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Alvarado et al. (2010)	imex:IM-14974|pubmed:20723758	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2911706|imex:IM-14974-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_476759.1|flybase:FBgn0003731|dip:DIP-17316N|ensemblmetazoa:FBgn0003731(gene)|ensemblmetazoa:FBtr0071654(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001742"(oenocyte differentiation)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0003015"(heart process)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007309"(oocyte axis specification)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007390"(germ-band shortening)|go:"GO:0007391"(dorsal closure)|go:"GO:0007395"(dorsal closure, spreading of leading edge cells)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007426"(tracheal outgrowth, open tracheal system)|go:"GO:0007431"(salivary gland development)|go:"GO:0007443"(Malpighian tubule morphogenesis)|go:"GO:0007444"(imaginal disc development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007472"(wing disc morphogenesis)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007477"(notum development)|go:"GO:0007479"(leg disc proximal/distal pattern formation)|go:"GO:0007482"(haltere development)|go:"GO:0008071"(maternal determination of dorsal/ventral axis, ovarian follicular epithelium, soma encoded)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008355"(olfactory learning)|go:"GO:0008406"(gonad development)|go:"GO:0008586"(imaginal disc-derived wing vein morphogenesis)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016318"(ommatidial rotation)|go:"GO:0016330"(second mitotic wave involved in compound eye morphogenesis)|go:"GO:0016333"(morphogenesis of follicular epithelium)|go:"GO:0022008"(neurogenesis)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030381"(chorion-containing eggshell pattern formation)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0035149"(lumen formation, open tracheal system)|go:"GO:0035159"(regulation of tube length, open tracheal system)|go:"GO:0035160"(maintenance of epithelial integrity, open tracheal system)|go:"GO:0035225"(determination of genital disc primordium)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0035309"(wing and notum subfield formation)|go:"GO:0035310"(notum cell fate specification)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042675"(compound eye cone cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043703"(photoreceptor cell fate determination)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0046530"(photoreceptor cell differentiation)|go:"GO:0046673"(negative regulation of compound eye retinal cell programmed cell death)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0048749"(compound eye development)|go:"GO:0048865"(stem cell fate commitment)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0061331"(epithelial cell proliferation involved in Malpighian tubule morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P04412|rcsb pdb:3I2T|rcsb pdb:3LTF|rcsb pdb:3LTG|reactome:R-DME-1227986|reactome:R-DME-1250196|reactome:R-DME-1251985|reactome:R-DME-1253288|reactome:R-DME-1257604|reactome:R-DME-1358803|reactome:R-DME-177929|reactome:R-DME-179812|reactome:R-DME-180292|reactome:R-DME-180336|reactome:R-DME-182971|reactome:R-DME-1963642|reactome:R-DME-212718|reactome:R-DME-2179392|reactome:R-DME-416572|reactome:R-DME-5673001|reactome:R-DME-6785631|reactome:R-DME-6811558|reactome:R-DME-8856825|reactome:R-DME-8856828|reactome:R-DME-8863795|reactome:R-DME-9018519|reactome:R-DME-9652282	go:"GO:0005789"(endoplasmic reticulum membrane)|ensemblmetazoa:FBgn0005672(gene)|ensemblmetazoa:FBtr0081267(transcript)|ensemblmetazoa:FBtr0081268(transcript)|ensemblmetazoa:FBtr0081269(transcript)|ensemblmetazoa:FBtr0081270(transcript)|ensemblmetazoa:FBtr0100597(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001713"(ectodermal cell fate determination)|go:"GO:0003015"(heart process)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|refseq:NP_001027281.1|refseq:NP_476909.2|refseq:NP_599118.2|refseq:NP_599119.2|refseq:NP_599120.2|flybase:FBgn0005672|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007391"(dorsal closure)|go:"GO:0007421"(stomatogastric nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007438"(oenocyte development)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008355"(olfactory learning)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016318"(ommatidial rotation)|go:"GO:0035225"(determination of genital disc primordium)|go:"GO:0035277"(spiracle morphogenesis, open tracheal system)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043703"(photoreceptor cell fate determination)|go:"GO:0046530"(photoreceptor cell differentiation)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048865"(stem cell fate commitment)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061331"(epithelial cell proliferation involved in Malpighian tubule morphogenesis)|go:"GO:1903688"(positive regulation of border follicle cell migration)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR043403|rcsb pdb:3C9A|rcsb pdb:3CA7|rcsb pdb:3LTF|rcsb pdb:3LTG|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|dip:DIP-18037N	psi-mi:"MI:0469"(intact)	-	-	comment:"Further deletion of the spi construct of the 6 C-terminal amino acids (remaining residues 76-126) lowered the Kd to 4.4E-6M"|figure legend:Supp. Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	rogid:Ae9kedh1v+TZ5zG4QorNPm9/FgA7227	rogid:RO8D5JspHbtNUFx11JHFCoUuv0A7227	intact-crc:3E17D2BB4A49AB17|rigid:x8ujv6G5KzGfNLeJgOtgQrj/A+A	false	sufficient binding region:100-668|his tag:c-c	sufficient binding region:76-133(IPR006209)	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)