#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P15692-4	intact:EBI-2912160	intact:EBI-1026691|ensembl:ENSP00000429643	-	psi-mi:p15692-4(display_long)|uniprotkb:VEGF(isoform synonym)|uniprotkb:VEGFA(gene name)|psi-mi:VEGFA(display_short)|uniprotkb:VEGF(gene name synonym)|uniprotkb:Vascular permeability factor(gene name synonym)	psi-mi:daap-4(display_short)|psi-mi:EBI-2912160(display_long)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2912109|imex:IM-15198-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1026643(vegfa_human)|ensembl:ENSG00000112715(gene)|ensembl:ENST00000523950(transcript)	-	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Fig 1B.|comment:DAAP-4 and DAAP-5 were capable of binding both VEGF-A and Ang-2, wheras DAAP-7 only bound to VEGFA.|caution:VEGFA is not explicitly stated to be tagged nor CHO cell derived.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	rogid:/DdgEEe0/rYnemiYvqxeQ+KiXXs9606	-	intact-crc:5678D375A15E9054	false	flag tag:?-?	tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
intact:EBI-2912160	uniprotkb:O15123	-	intact:EBI-2912111|ensembl:ENSP00000314897|uniprotkb:B7ZLM7|uniprotkb:A0AV38|uniprotkb:A8K205|uniprotkb:Q9NRR7|uniprotkb:Q9P2Y7	psi-mi:daap-4(display_short)|psi-mi:EBI-2912160(display_long)	psi-mi:angp2_human(display_long)|uniprotkb:ANGPT2(gene name)|psi-mi:ANGPT2(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2912147|imex:IM-15198-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000091879(gene)|ensembl:ENST00000325203(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007281"(germ cell development)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0010467"(gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0042995"(cell projection)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0050928"(negative regulation of positive chemotaxis)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0072012"(glomerulus vasculature development)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028844|interpro:IPR036056|rcsb pdb:1Z3S|rcsb pdb:1Z3U|rcsb pdb:4ZFG|rcsb pdb:2GY7|reactome:R-HSA-210993|rcsb pdb:4JZC|refseq:NP_001112359.1|refseq:NP_001112360.1|refseq:NP_001138.1|dip:DIP-6048N	psi-mi:"MI:0469"(intact)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Fig 1B, S1A.|comment:"DAAP-4 and DAAP-5 were capable of binding both VEGF-A and Ang-2, wheras DAAP-7 only bound to VEGFA.  The Tie2 (Ig2 domain+Fc) also weakly binds to Ang-2."|caution:Ang-2 is not explicitly stated to be tagged nor CHO cell derived.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	-	rogid:p1gSsi5cIt3Lp6o5fA4fVAtvZD49606	intact-crc:F434BEE944C29627	false	tag:c-c	flag tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P15692-4	intact:EBI-2912164	intact:EBI-1026691|ensembl:ENSP00000429643	-	psi-mi:p15692-4(display_long)|uniprotkb:VEGF(isoform synonym)|uniprotkb:VEGFA(gene name)|psi-mi:VEGFA(display_short)|uniprotkb:VEGF(gene name synonym)|uniprotkb:Vascular permeability factor(gene name synonym)	psi-mi:daap-5(display_short)|psi-mi:EBI-2912164(display_long)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2912948|imex:IM-15198-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1026643(vegfa_human)|ensembl:ENSG00000112715(gene)|ensembl:ENST00000523950(transcript)	-	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Fig 1B, 1D.|comment:DAAP-4 and DAAP-5 were capable of binding both VEGF-A and Ang-2, wheras DAAP-7 only bound to VEGFA.|kinetics:Affinity constant for VEGFA165/DAAP-5 binding is ~4.6pM.|caution:VEGFA is not explicitly stated to be tagged nor CHO cell derived.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	rogid:/DdgEEe0/rYnemiYvqxeQ+KiXXs9606	-	intact-crc:5044374B95E5D177	false	flag tag:?-?	tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P15692-4	intact:EBI-2912166	intact:EBI-1026691|ensembl:ENSP00000429643	-	psi-mi:p15692-4(display_long)|uniprotkb:VEGF(isoform synonym)|uniprotkb:VEGFA(gene name)|psi-mi:VEGFA(display_short)|uniprotkb:VEGF(gene name synonym)|uniprotkb:Vascular permeability factor(gene name synonym)	psi-mi:daap-7(display_short)|psi-mi:EBI-2912166(display_long)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2912962|imex:IM-15198-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1026643(vegfa_human)|ensembl:ENSG00000112715(gene)|ensembl:ENST00000523950(transcript)	-	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Fig 1B.|comment:DAAP-4 and DAAP-5 were capable of binding both VEGF-A and Ang-2, wheras DAAP-7 only bound to VEGFA.|caution:VEGFA is not explicitly stated to be tagged nor CHO cell derived.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	rogid:/DdgEEe0/rYnemiYvqxeQ+KiXXs9606	-	intact-crc:C3D3B759D7EB4690	false	flag tag:?-?	tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O15123	intact:EBI-2912164	intact:EBI-2912111|ensembl:ENSP00000314897|uniprotkb:B7ZLM7|uniprotkb:A0AV38|uniprotkb:A8K205|uniprotkb:Q9NRR7|uniprotkb:Q9P2Y7	-	psi-mi:angp2_human(display_long)|uniprotkb:ANGPT2(gene name)|psi-mi:ANGPT2(display_short)	psi-mi:daap-5(display_short)|psi-mi:EBI-2912164(display_long)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2912980|imex:IM-15198-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000091879(gene)|ensembl:ENST00000325203(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007281"(germ cell development)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0010467"(gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0042995"(cell projection)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0050928"(negative regulation of positive chemotaxis)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0072012"(glomerulus vasculature development)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028844|interpro:IPR036056|rcsb pdb:1Z3S|rcsb pdb:1Z3U|rcsb pdb:4ZFG|rcsb pdb:2GY7|reactome:R-HSA-210993|rcsb pdb:4JZC|refseq:NP_001112359.1|refseq:NP_001112360.1|refseq:NP_001138.1|dip:DIP-6048N	-	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Fig 1B, S1A, 1E.|comment:"DAAP-4 and DAAP-5 were capable of binding both VEGF-A and Ang-2, wheras DAAP-7 only bound to VEGFA.  The Tie2 (Ig2 domain+Fc) also weakly binds to Ang-2."|kinetics:Affinity constant for Ang2/DAAP-5 binding is ~10pM.|caution:Ang-2 is not explicitly stated to be tagged nor CHO cell derived.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	rogid:p1gSsi5cIt3Lp6o5fA4fVAtvZD49606	-	intact-crc:1F1DCD9BE416EF11	false	flag tag:?-?	tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O15123	uniprotkb:Q02763	intact:EBI-2912111|ensembl:ENSP00000314897|uniprotkb:B7ZLM7|uniprotkb:A0AV38|uniprotkb:A8K205|uniprotkb:Q9NRR7|uniprotkb:Q9P2Y7	intact:EBI-2257090|uniprotkb:A8K6W0|uniprotkb:Q5TCU2|uniprotkb:B4DH20|uniprotkb:B4DHD3|uniprotkb:E7EWI2|uniprotkb:Q8IV34|uniprotkb:D3DRK5|ensembl:ENSP00000369375	psi-mi:angp2_human(display_long)|uniprotkb:ANGPT2(gene name)|psi-mi:ANGPT2(display_short)	psi-mi:tie2_human(display_long)|uniprotkb:TEK(gene name)|psi-mi:TEK(display_short)|uniprotkb:TIE2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TIE-2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TEK(gene name synonym)|uniprotkb:Tunica interna endothelial cell kinase(gene name synonym)|uniprotkb:p140 TEK(gene name synonym)|uniprotkb:Endothelial tyrosine kinase(gene name synonym)|uniprotkb:Tyrosine kinase with Ig and EGF homology domains-2(gene name synonym)|uniprotkb:VMCM(gene name synonym)|uniprotkb:VMCM1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2912996|imex:IM-15198-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000091879(gene)|ensembl:ENST00000325203(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007281"(germ cell development)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0010467"(gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0042995"(cell projection)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0050928"(negative regulation of positive chemotaxis)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0072012"(glomerulus vasculature development)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028844|interpro:IPR036056|rcsb pdb:1Z3S|rcsb pdb:1Z3U|rcsb pdb:4ZFG|rcsb pdb:2GY7|reactome:R-HSA-210993|rcsb pdb:4JZC|refseq:NP_001112359.1|refseq:NP_001112360.1|refseq:NP_001138.1|dip:DIP-6048N	refseq:NP_000450.2|dip:DIP-6047N|refseq:NP_001277006.1|refseq:NP_001277007.1|ensembl:ENSG00000120156(gene)|ensembl:ENST00000380036(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0032878"(regulation of establishment or maintenance of cell polarity)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034451"(centriolar satellite)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051591"(response to cAMP)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072012"(glomerulus vasculature development)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018941|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|mint:Q02763|rcsb pdb:1FVR|rcsb pdb:2GY5|rcsb pdb:2GY7|rcsb pdb:2OO8|rcsb pdb:2OSC|rcsb pdb:2P4I|rcsb pdb:2WQB|rcsb pdb:3BEA|rcsb pdb:3L8P|rcsb pdb:4K0V|rcsb pdb:4X3J|rcsb pdb:5MYA|rcsb pdb:5MYB|rcsb pdb:5UTK|rcsb pdb:6MWE|reactome:R-HSA-210993|reactome:R-HSA-5673001	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1B, S1A.|comment:"DAAP-4 and DAAP-5 were capable of binding both VEGF-A and Ang-2, wheras DAAP-7 only bound to VEGFA.  The Tie2 (Ig2 domain+Fc) also weakly binds to Ang-2."|caution:Ang-2 is not explicitly stated to be tagged nor CHO cell derived.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	rogid:p1gSsi5cIt3Lp6o5fA4fVAtvZD49606	rogid:iZHZ6RvLXT65o6FTQaHW+cnrX1o9606	intact-crc:D6A7D43E5C9D883F|rigid:mPg1eFmFuJbz1da5Lb+Up2Dm83U	false	flag tag:?-?	tag:c-c|sufficient binding region:122-213	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P15692-4	intact:EBI-2922463	intact:EBI-1026691|ensembl:ENSP00000429643	-	psi-mi:p15692-4(display_long)|uniprotkb:VEGF(isoform synonym)|uniprotkb:VEGFA(gene name)|psi-mi:VEGFA(display_short)|uniprotkb:VEGF(gene name synonym)|uniprotkb:Vascular permeability factor(gene name synonym)	psi-mi:vegf_trap(display_short)|psi-mi:EBI-2922463(display_long)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2922701|imex:IM-15198-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1026643(vegfa_human)|ensembl:ENSG00000112715(gene)|ensembl:ENST00000523950(transcript)	-	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Fig 1D, S1I.|kinetics:Affinity constant for VEGFA165/VEGF-Trap binding is ~1.7pM.|caution:The VEGFA is not explicitly stated to be flag-tagged nor CHO cell derived.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	rogid:/DdgEEe0/rYnemiYvqxeQ+KiXXs9606	-	intact-crc:AB8FFBAD882E1F9F	false	flag tag:?-?	tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q02763	uniprotkb:O15123	intact:EBI-2257090|uniprotkb:A8K6W0|uniprotkb:Q5TCU2|uniprotkb:B4DH20|uniprotkb:B4DHD3|uniprotkb:E7EWI2|uniprotkb:Q8IV34|uniprotkb:D3DRK5|ensembl:ENSP00000369375	intact:EBI-2912111|ensembl:ENSP00000314897|uniprotkb:B7ZLM7|uniprotkb:A0AV38|uniprotkb:A8K205|uniprotkb:Q9NRR7|uniprotkb:Q9P2Y7	psi-mi:tie2_human(display_long)|uniprotkb:TEK(gene name)|psi-mi:TEK(display_short)|uniprotkb:TIE2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TIE-2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TEK(gene name synonym)|uniprotkb:Tunica interna endothelial cell kinase(gene name synonym)|uniprotkb:p140 TEK(gene name synonym)|uniprotkb:Endothelial tyrosine kinase(gene name synonym)|uniprotkb:Tyrosine kinase with Ig and EGF homology domains-2(gene name synonym)|uniprotkb:VMCM(gene name synonym)|uniprotkb:VMCM1(gene name synonym)	psi-mi:angp2_human(display_long)|uniprotkb:ANGPT2(gene name)|psi-mi:ANGPT2(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2922712|imex:IM-15198-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000450.2|dip:DIP-6047N|refseq:NP_001277006.1|refseq:NP_001277007.1|ensembl:ENSG00000120156(gene)|ensembl:ENST00000380036(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0032878"(regulation of establishment or maintenance of cell polarity)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034451"(centriolar satellite)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051591"(response to cAMP)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072012"(glomerulus vasculature development)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018941|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|mint:Q02763|rcsb pdb:1FVR|rcsb pdb:2GY5|rcsb pdb:2GY7|rcsb pdb:2OO8|rcsb pdb:2OSC|rcsb pdb:2P4I|rcsb pdb:2WQB|rcsb pdb:3BEA|rcsb pdb:3L8P|rcsb pdb:4K0V|rcsb pdb:4X3J|rcsb pdb:5MYA|rcsb pdb:5MYB|rcsb pdb:5UTK|rcsb pdb:6MWE|reactome:R-HSA-210993|reactome:R-HSA-5673001	ensembl:ENSG00000091879(gene)|ensembl:ENST00000325203(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007281"(germ cell development)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0010467"(gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0042995"(cell projection)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0050928"(negative regulation of positive chemotaxis)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0072012"(glomerulus vasculature development)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028844|interpro:IPR036056|rcsb pdb:1Z3S|rcsb pdb:1Z3U|rcsb pdb:4ZFG|rcsb pdb:2GY7|reactome:R-HSA-210993|rcsb pdb:4JZC|refseq:NP_001112359.1|refseq:NP_001112360.1|refseq:NP_001138.1|dip:DIP-6048N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1E, S1J.|kinetics:Affinity constant for Tie2-Fc/ang2 binding is ~50pM.|caution:Ang-2 is not explicitly stated to be tagged nor CHO cell derived.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	rogid:iZHZ6RvLXT65o6FTQaHW+cnrX1o9606	rogid:p1gSsi5cIt3Lp6o5fA4fVAtvZD49606	intact-crc:15852AD898640614|rigid:mPg1eFmFuJbz1da5Lb+Up2Dm83U	false	sufficient binding region:1-348|tag:c-c	flag tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
intact:EBI-2912164	uniprotkb:O15123	-	intact:EBI-2912111|ensembl:ENSP00000314897|uniprotkb:B7ZLM7|uniprotkb:A0AV38|uniprotkb:A8K205|uniprotkb:Q9NRR7|uniprotkb:Q9P2Y7	psi-mi:daap-5(display_short)|psi-mi:EBI-2912164(display_long)	psi-mi:angp2_human(display_long)|uniprotkb:ANGPT2(gene name)|psi-mi:ANGPT2(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2922867|imex:IM-15198-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000091879(gene)|ensembl:ENST00000325203(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007281"(germ cell development)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0010467"(gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0042995"(cell projection)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0050928"(negative regulation of positive chemotaxis)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0072012"(glomerulus vasculature development)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028844|interpro:IPR036056|rcsb pdb:1Z3S|rcsb pdb:1Z3U|rcsb pdb:4ZFG|rcsb pdb:2GY7|reactome:R-HSA-210993|rcsb pdb:4JZC|refseq:NP_001112359.1|refseq:NP_001112360.1|refseq:NP_001138.1|dip:DIP-6048N	psi-mi:"MI:0469"(intact)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Fig S1 I-J.|comment:Preoccupation of one binding site on DAAP with VEGF-A or Ang-2 further enhanced its binding activity to the other ligand- Ang-2 or VEGF-A.|caution:Neither VEFGA nor Ang-2 are explicitly stated to be tagged or CHO cell derived.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	-	rogid:p1gSsi5cIt3Lp6o5fA4fVAtvZD49606	intact-crc:DDB54AB426ED09CA	false	tag:c-c	flag tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
intact:EBI-2912164	uniprotkb:P15692-4	-	intact:EBI-1026691|ensembl:ENSP00000429643	psi-mi:daap-5(display_short)|psi-mi:EBI-2912164(display_long)	psi-mi:p15692-4(display_long)|uniprotkb:VEGF(isoform synonym)|uniprotkb:VEGFA(gene name)|psi-mi:VEGFA(display_short)|uniprotkb:VEGF(gene name synonym)|uniprotkb:Vascular permeability factor(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2922867|imex:IM-15198-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	intact:EBI-1026643(vegfa_human)|ensembl:ENSG00000112715(gene)|ensembl:ENST00000523950(transcript)	psi-mi:"MI:0469"(intact)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Fig S1 I-J.|comment:Preoccupation of one binding site on DAAP with VEGF-A or Ang-2 further enhanced its binding activity to the other ligand- Ang-2 or VEGF-A.|caution:Neither VEFGA nor Ang-2 are explicitly stated to be tagged or CHO cell derived.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	-	rogid:/DdgEEe0/rYnemiYvqxeQ+KiXXs9606	intact-crc:DDB54AB426ED09CA	false	tag:c-c	flag tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P15692-4	uniprotkb:O15123	intact:EBI-1026691|ensembl:ENSP00000429643	intact:EBI-2912111|ensembl:ENSP00000314897|uniprotkb:B7ZLM7|uniprotkb:A0AV38|uniprotkb:A8K205|uniprotkb:Q9NRR7|uniprotkb:Q9P2Y7	psi-mi:p15692-4(display_long)|uniprotkb:VEGF(isoform synonym)|uniprotkb:VEGFA(gene name)|psi-mi:VEGFA(display_short)|uniprotkb:VEGF(gene name synonym)|uniprotkb:Vascular permeability factor(gene name synonym)	psi-mi:angp2_human(display_long)|uniprotkb:ANGPT2(gene name)|psi-mi:ANGPT2(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2922878|imex:IM-15198-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1026643(vegfa_human)|ensembl:ENSG00000112715(gene)|ensembl:ENST00000523950(transcript)	ensembl:ENSG00000091879(gene)|ensembl:ENST00000325203(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007281"(germ cell development)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0010467"(gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0042995"(cell projection)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0050928"(negative regulation of positive chemotaxis)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0072012"(glomerulus vasculature development)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028844|interpro:IPR036056|rcsb pdb:1Z3S|rcsb pdb:1Z3U|rcsb pdb:4ZFG|rcsb pdb:2GY7|reactome:R-HSA-210993|rcsb pdb:4JZC|refseq:NP_001112359.1|refseq:NP_001112360.1|refseq:NP_001138.1|dip:DIP-6048N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1 L.|comment:DAAP is capable of simultaneously binding VEGF-A and Ang-2.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	rogid:/DdgEEe0/rYnemiYvqxeQ+KiXXs9606	rogid:p1gSsi5cIt3Lp6o5fA4fVAtvZD49606	intact-crc:1FAD57FF1809293A	false	flag tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P15692-4	intact:EBI-2912164	intact:EBI-1026691|ensembl:ENSP00000429643	-	psi-mi:p15692-4(display_long)|uniprotkb:VEGF(isoform synonym)|uniprotkb:VEGFA(gene name)|psi-mi:VEGFA(display_short)|uniprotkb:VEGF(gene name synonym)|uniprotkb:Vascular permeability factor(gene name synonym)	psi-mi:daap-5(display_short)|psi-mi:EBI-2912164(display_long)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2922878|imex:IM-15198-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1026643(vegfa_human)|ensembl:ENSG00000112715(gene)|ensembl:ENST00000523950(transcript)	-	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Fig S1 L.|comment:DAAP is capable of simultaneously binding VEGF-A and Ang-2.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	rogid:/DdgEEe0/rYnemiYvqxeQ+KiXXs9606	-	intact-crc:1FAD57FF1809293A	false	flag tag:?-?	tag:c-c	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P15692-4	intact:EBI-2912164	intact:EBI-1026691|ensembl:ENSP00000429643	-	psi-mi:p15692-4(display_long)|uniprotkb:VEGF(isoform synonym)|uniprotkb:VEGFA(gene name)|psi-mi:VEGFA(display_short)|uniprotkb:VEGF(gene name synonym)|uniprotkb:Vascular permeability factor(gene name synonym)	psi-mi:daap-5(display_short)|psi-mi:EBI-2912164(display_long)	psi-mi:"MI:0096"(pull down)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2912801|imex:IM-15198-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1026643(vegfa_human)|ensembl:ENSG00000112715(gene)|ensembl:ENST00000523950(transcript)	-	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Fig 1C.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	rogid:/DdgEEe0/rYnemiYvqxeQ+KiXXs9606	-	intact-crc:160B3301CD1B5C3B	false	flag tag:?-?	tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
intact:EBI-2912164	uniprotkb:Q00731-2	-	intact:EBI-444787	psi-mi:daap-5(display_short)|psi-mi:EBI-2912164(display_long)	psi-mi:q00731-2(display_long)|uniprotkb:VEGF164(isoform synonym)|uniprotkb:Vegfa(gene name)|psi-mi:Vegfa(display_short)|uniprotkb:Vegf(gene name synonym)|uniprotkb:Vascular permeability factor(gene name synonym)	psi-mi:"MI:0096"(pull down)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2913155|imex:IM-15198-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	intact:EBI-444774(vegfa_mouse)	psi-mi:"MI:0469"(intact)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Fig 1C.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	-	rogid:L4U2WwGMToRZIrBcDmi5W/b8wJc10090	intact-crc:45362A741E2095FA	false	tag:c-c	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P15692-2	intact:EBI-2912164	intact:EBI-1026683|ensembl:ENSP00000428321	-	psi-mi:p15692-2(display_long)|uniprotkb:VEGFA(gene name)|psi-mi:VEGFA(display_short)|uniprotkb:VEGF(gene name synonym)|uniprotkb:Vascular permeability factor(gene name synonym)	psi-mi:daap-5(display_short)|psi-mi:EBI-2912164(display_long)	psi-mi:"MI:0096"(pull down)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2913169|imex:IM-15198-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1026643(vegfa_human)|ensembl:ENSG00000112715(gene)|ensembl:ENST00000520948(transcript)	-	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Fig 1C.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	rogid:xyhtIVOra/Ynlw+hN6rhXWBENBU9606	-	intact-crc:CDF1588A34FCAED4	false	flag tag:?-?	tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P15692-9	intact:EBI-2912164	intact:EBI-1026713|ensembl:ENSP00000361148	-	psi-mi:p15692-9(display_long)|uniprotkb:VEGFA(gene name)|psi-mi:VEGFA(display_short)|uniprotkb:VEGF(gene name synonym)|uniprotkb:Vascular permeability factor(gene name synonym)	psi-mi:daap-5(display_short)|psi-mi:EBI-2912164(display_long)	psi-mi:"MI:0096"(pull down)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2913201|imex:IM-15198-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1026643(vegfa_human)|ensembl:ENSG00000112715(gene)|ensembl:ENST00000372077(transcript)	-	psi-mi:"MI:0469"(intact)	isoform-comment:No experimental confirmation available.	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Fig 1C.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	rogid:nyK0fw9BPrYJv5uxvKM6JFI4TpI9606	-	intact-crc:0D4988C8B4A42280	false	flag tag:?-?	tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O09101	intact:EBI-2912164	intact:EBI-2922307|ensembl:ENSMUSP00000024957	-	psi-mi:pigf_mouse(display_long)|uniprotkb:Pigf(gene name)|psi-mi:Pigf(display_short)	psi-mi:daap-5(display_short)|psi-mi:EBI-2912164(display_long)	psi-mi:"MI:0096"(pull down)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2922319|imex:IM-15198-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000024145(gene)|ensembl:ENSMUST00000024957(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006506"(GPI anchor biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016780"(phosphotransferase activity, for other substituted phosphate groups)|go:"GO:0051377"(mannose-ethanolamine phosphotransferase activity)|interpro:IPR009580(Glycosylphosphatidylinositol anchor biosynthesis)|reactome:R-MMU-162710|refseq:NP_032864.1|refseq:XP_006523894.1	-	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Fig 1C.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	rogid:X2aEYe9KvIwbT7qHhUSFQJ0qutU10090	-	intact-crc:96F05A75330CD426	false	flag tag:?-?	tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
intact:EBI-2912164	uniprotkb:O15123	-	intact:EBI-2912111|ensembl:ENSP00000314897|uniprotkb:B7ZLM7|uniprotkb:A0AV38|uniprotkb:A8K205|uniprotkb:Q9NRR7|uniprotkb:Q9P2Y7	psi-mi:daap-5(display_short)|psi-mi:EBI-2912164(display_long)	psi-mi:angp2_human(display_long)|uniprotkb:ANGPT2(gene name)|psi-mi:ANGPT2(display_short)	psi-mi:"MI:0096"(pull down)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2922325|imex:IM-15198-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000091879(gene)|ensembl:ENST00000325203(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007281"(germ cell development)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0010467"(gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0042995"(cell projection)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0050928"(negative regulation of positive chemotaxis)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0072012"(glomerulus vasculature development)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028844|interpro:IPR036056|rcsb pdb:1Z3S|rcsb pdb:1Z3U|rcsb pdb:4ZFG|rcsb pdb:2GY7|reactome:R-HSA-210993|rcsb pdb:4JZC|refseq:NP_001112359.1|refseq:NP_001112360.1|refseq:NP_001138.1|dip:DIP-6048N	psi-mi:"MI:0469"(intact)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Fig 1C.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	-	rogid:p1gSsi5cIt3Lp6o5fA4fVAtvZD49606	intact-crc:985CF88B14DCADFF	false	tag:c-c	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
intact:EBI-2912164	uniprotkb:O35608	-	intact:EBI-2922337|ensembl:ENSMUSP00000033846|uniprotkb:Q3U1A1|uniprotkb:Q9D2D2	psi-mi:daap-5(display_short)|psi-mi:EBI-2912164(display_long)	psi-mi:angp2_mouse(display_long)|uniprotkb:Angpt2(gene name)|psi-mi:Angpt2(display_short)|uniprotkb:Agpt2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2922357|imex:IM-15198-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSMUSG00000031465(gene)|ensembl:ENSMUST00000033846(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007281"(germ cell development)|go:"GO:0007492"(endoderm development)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0010467"(gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0042995"(cell projection)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050928"(negative regulation of positive chemotaxis)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0072012"(glomerulus vasculature development)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028844|interpro:IPR036056|reactome:R-MMU-210993|refseq:NP_031452.2	psi-mi:"MI:0469"(intact)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Fig 1C.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	-	rogid:JepnLuARYPv22/8BkvefyalSJks10090	intact-crc:DB2577A5C94728C5	false	tag:c-c	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
intact:EBI-2912164	uniprotkb:Q15389	-	intact:EBI-2922365|ensembl:ENSP00000428340|uniprotkb:Q5HYA0	psi-mi:daap-5(display_short)|psi-mi:EBI-2912164(display_long)	psi-mi:angp1_human(display_long)|uniprotkb:ANGPT1(gene name)|psi-mi:ANGPT1(display_short)|uniprotkb:KIAA0003(gene name synonym)	psi-mi:"MI:0096"(pull down)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2922399|imex:IM-15198-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000154188(gene)|ensembl:ENST00000517746(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007171"(activation of transmembrane receptor protein tyrosine kinase activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014842"(regulation of skeletal muscle satellite cell proliferation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030210"(heparin biosynthetic process)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072012"(glomerulus vasculature development)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000446"(regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028843|interpro:IPR036056|mint:Q15389|rcsb pdb:4EPU|rcsb pdb:4JYO|rcsb pdb:4K0V|reactome:R-HSA-210993|reactome:R-HSA-5673001|go:"GO:0031398"(positive regulation of protein ubiquitination)|refseq:NP_001137.2|refseq:NP_001186788.1|refseq:NP_001300980.1	psi-mi:"MI:0469"(intact)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Fig 1C.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	-	rogid:UQX0FGhzdmPbYOvuvmXxBdkEgjk9606	intact-crc:EE51EFA7D3E1EE3B	false	tag:c-c	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
intact:EBI-2912164	uniprotkb:Q9WVH6	-	intact:EBI-2922406|ensembl:ENSMUSP00000028955	psi-mi:daap-5(display_short)|psi-mi:EBI-2912164(display_long)	psi-mi:angp4_mouse(display_long)|uniprotkb:Angpt4(gene name)|psi-mi:Angpt4(display_short)|uniprotkb:Agpt4(gene name synonym)|uniprotkb:Ang3(gene name synonym)|uniprotkb:Angiopoietin-3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2922421|imex:IM-15198-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSMUSG00000027460(gene)|ensembl:ENSMUST00000028955(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007165"(signal transduction)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007492"(endoderm development)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028845|interpro:IPR036056|mint:Q9WVH6|reactome:R-MMU-210993|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|refseq:NP_033771.1	psi-mi:"MI:0469"(intact)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Fig 1C.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	-	rogid:DmktKRZPrgDdIsSFA1eAToNqeog10090	intact-crc:65AD45EBC23F0095	false	tag:c-c	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
intact:EBI-2912164	uniprotkb:Q9Y264	-	intact:EBI-2922429|ensembl:ENSP00000371347|uniprotkb:Q5TFF4|uniprotkb:Q9H4Z4|uniprotkb:B4E3J9	psi-mi:daap-5(display_short)|psi-mi:EBI-2912164(display_long)	psi-mi:angp4_human(display_long)|uniprotkb:ANGPT4(gene name)|psi-mi:ANGPT4(display_short)|uniprotkb:ANG3(gene name synonym)|uniprotkb:ANG4(gene name synonym)|uniprotkb:Angiopoietin-3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2922455|imex:IM-15198-28	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000101280(gene)|ensembl:ENST00000381922(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0007165"(signal transduction)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028845|interpro:IPR036056|reactome:R-HSA-210993|refseq:NP_057069.1|refseq:NP_001309738.1	psi-mi:"MI:0469"(intact)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Fig 1C.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	-	rogid:yiz0QDZ2CRrTm/0Khuv1OR2F8Vg9606	intact-crc:3055B1AF6B7017B3	false	tag:c-c	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
intact:EBI-2922463	uniprotkb:P15692-4	-	intact:EBI-1026691|ensembl:ENSP00000429643	psi-mi:vegf_trap(display_short)|psi-mi:EBI-2922463(display_long)	psi-mi:p15692-4(display_long)|uniprotkb:VEGF(isoform synonym)|uniprotkb:VEGFA(gene name)|psi-mi:VEGFA(display_short)|uniprotkb:VEGF(gene name synonym)|uniprotkb:Vascular permeability factor(gene name synonym)	psi-mi:"MI:0096"(pull down)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2922465|imex:IM-15198-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	intact:EBI-1026643(vegfa_human)|ensembl:ENSG00000112715(gene)|ensembl:ENST00000523950(transcript)	psi-mi:"MI:0469"(intact)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Fig 1C.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	-	rogid:/DdgEEe0/rYnemiYvqxeQ+KiXXs9606	intact-crc:D8BDFF296416839E	false	tag:c-c	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q00731-2	intact:EBI-2922463	intact:EBI-444787	-	psi-mi:q00731-2(display_long)|uniprotkb:VEGF164(isoform synonym)|uniprotkb:Vegfa(gene name)|psi-mi:Vegfa(display_short)|uniprotkb:Vegf(gene name synonym)|uniprotkb:Vascular permeability factor(gene name synonym)	psi-mi:vegf_trap(display_short)|psi-mi:EBI-2922463(display_long)	psi-mi:"MI:0096"(pull down)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2922475|imex:IM-15198-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-444774(vegfa_mouse)	-	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Fig 1C.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	rogid:L4U2WwGMToRZIrBcDmi5W/b8wJc10090	-	intact-crc:1031CFE750466A35	false	flag tag:?-?	tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P15692-2	intact:EBI-2922463	intact:EBI-1026683|ensembl:ENSP00000428321	-	psi-mi:p15692-2(display_long)|uniprotkb:VEGFA(gene name)|psi-mi:VEGFA(display_short)|uniprotkb:VEGF(gene name synonym)|uniprotkb:Vascular permeability factor(gene name synonym)	psi-mi:vegf_trap(display_short)|psi-mi:EBI-2922463(display_long)	psi-mi:"MI:0096"(pull down)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2922486|imex:IM-15198-26	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1026643(vegfa_human)|ensembl:ENSG00000112715(gene)|ensembl:ENST00000520948(transcript)	-	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Fig 1C.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	rogid:xyhtIVOra/Ynlw+hN6rhXWBENBU9606	-	intact-crc:C8C061B902B63F9E	false	flag tag:?-?	tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P15692-9	intact:EBI-2922463	intact:EBI-1026713|ensembl:ENSP00000361148	-	psi-mi:p15692-9(display_long)|uniprotkb:VEGFA(gene name)|psi-mi:VEGFA(display_short)|uniprotkb:VEGF(gene name synonym)|uniprotkb:Vascular permeability factor(gene name synonym)	psi-mi:vegf_trap(display_short)|psi-mi:EBI-2922463(display_long)	psi-mi:"MI:0096"(pull down)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2922497|imex:IM-15198-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1026643(vegfa_human)|ensembl:ENSG00000112715(gene)|ensembl:ENST00000372077(transcript)	-	psi-mi:"MI:0469"(intact)	isoform-comment:No experimental confirmation available.	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Fig 1C.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	rogid:nyK0fw9BPrYJv5uxvKM6JFI4TpI9606	-	intact-crc:135457609DAFE553	false	flag tag:?-?	tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O09101	intact:EBI-2922463	intact:EBI-2922307|ensembl:ENSMUSP00000024957	-	psi-mi:pigf_mouse(display_long)|uniprotkb:Pigf(gene name)|psi-mi:Pigf(display_short)	psi-mi:vegf_trap(display_short)|psi-mi:EBI-2922463(display_long)	psi-mi:"MI:0096"(pull down)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2922508|imex:IM-15198-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000024145(gene)|ensembl:ENSMUST00000024957(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006506"(GPI anchor biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016780"(phosphotransferase activity, for other substituted phosphate groups)|go:"GO:0051377"(mannose-ethanolamine phosphotransferase activity)|interpro:IPR009580(Glycosylphosphatidylinositol anchor biosynthesis)|reactome:R-MMU-162710|refseq:NP_032864.1|refseq:XP_006523894.1	-	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Fig 1C.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	rogid:X2aEYe9KvIwbT7qHhUSFQJ0qutU10090	-	intact-crc:F672C46036D272A9	false	flag tag:?-?	tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q02763	uniprotkb:O15123	intact:EBI-2257090|uniprotkb:A8K6W0|uniprotkb:Q5TCU2|uniprotkb:B4DH20|uniprotkb:B4DHD3|uniprotkb:E7EWI2|uniprotkb:Q8IV34|uniprotkb:D3DRK5|ensembl:ENSP00000369375	intact:EBI-2912111|ensembl:ENSP00000314897|uniprotkb:B7ZLM7|uniprotkb:A0AV38|uniprotkb:A8K205|uniprotkb:Q9NRR7|uniprotkb:Q9P2Y7	psi-mi:tie2_human(display_long)|uniprotkb:TEK(gene name)|psi-mi:TEK(display_short)|uniprotkb:TIE2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TIE-2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TEK(gene name synonym)|uniprotkb:Tunica interna endothelial cell kinase(gene name synonym)|uniprotkb:p140 TEK(gene name synonym)|uniprotkb:Endothelial tyrosine kinase(gene name synonym)|uniprotkb:Tyrosine kinase with Ig and EGF homology domains-2(gene name synonym)|uniprotkb:VMCM(gene name synonym)|uniprotkb:VMCM1(gene name synonym)	psi-mi:angp2_human(display_long)|uniprotkb:ANGPT2(gene name)|psi-mi:ANGPT2(display_short)	psi-mi:"MI:0096"(pull down)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2922518|imex:IM-15198-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000450.2|dip:DIP-6047N|refseq:NP_001277006.1|refseq:NP_001277007.1|ensembl:ENSG00000120156(gene)|ensembl:ENST00000380036(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0032878"(regulation of establishment or maintenance of cell polarity)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034451"(centriolar satellite)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051591"(response to cAMP)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072012"(glomerulus vasculature development)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018941|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|mint:Q02763|rcsb pdb:1FVR|rcsb pdb:2GY5|rcsb pdb:2GY7|rcsb pdb:2OO8|rcsb pdb:2OSC|rcsb pdb:2P4I|rcsb pdb:2WQB|rcsb pdb:3BEA|rcsb pdb:3L8P|rcsb pdb:4K0V|rcsb pdb:4X3J|rcsb pdb:5MYA|rcsb pdb:5MYB|rcsb pdb:5UTK|rcsb pdb:6MWE|reactome:R-HSA-210993|reactome:R-HSA-5673001	ensembl:ENSG00000091879(gene)|ensembl:ENST00000325203(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007281"(germ cell development)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0010467"(gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0042995"(cell projection)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0050928"(negative regulation of positive chemotaxis)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0072012"(glomerulus vasculature development)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028844|interpro:IPR036056|rcsb pdb:1Z3S|rcsb pdb:1Z3U|rcsb pdb:4ZFG|rcsb pdb:2GY7|reactome:R-HSA-210993|rcsb pdb:4JZC|refseq:NP_001112359.1|refseq:NP_001112360.1|refseq:NP_001138.1|dip:DIP-6048N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1C.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	rogid:iZHZ6RvLXT65o6FTQaHW+cnrX1o9606	rogid:p1gSsi5cIt3Lp6o5fA4fVAtvZD49606	intact-crc:301DDD94BF6E52C9|rigid:mPg1eFmFuJbz1da5Lb+Up2Dm83U	false	sufficient binding region:1-348|tag:c-c	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O35608	uniprotkb:Q02763	intact:EBI-2922337|ensembl:ENSMUSP00000033846|uniprotkb:Q3U1A1|uniprotkb:Q9D2D2	intact:EBI-2257090|uniprotkb:A8K6W0|uniprotkb:Q5TCU2|uniprotkb:B4DH20|uniprotkb:B4DHD3|uniprotkb:E7EWI2|uniprotkb:Q8IV34|uniprotkb:D3DRK5|ensembl:ENSP00000369375	psi-mi:angp2_mouse(display_long)|uniprotkb:Angpt2(gene name)|psi-mi:Angpt2(display_short)|uniprotkb:Agpt2(gene name synonym)	psi-mi:tie2_human(display_long)|uniprotkb:TEK(gene name)|psi-mi:TEK(display_short)|uniprotkb:TIE2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TIE-2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TEK(gene name synonym)|uniprotkb:Tunica interna endothelial cell kinase(gene name synonym)|uniprotkb:p140 TEK(gene name synonym)|uniprotkb:Endothelial tyrosine kinase(gene name synonym)|uniprotkb:Tyrosine kinase with Ig and EGF homology domains-2(gene name synonym)|uniprotkb:VMCM(gene name synonym)|uniprotkb:VMCM1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2922530|imex:IM-15198-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031465(gene)|ensembl:ENSMUST00000033846(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007281"(germ cell development)|go:"GO:0007492"(endoderm development)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0010467"(gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0042995"(cell projection)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050928"(negative regulation of positive chemotaxis)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0072012"(glomerulus vasculature development)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028844|interpro:IPR036056|reactome:R-MMU-210993|refseq:NP_031452.2	refseq:NP_000450.2|dip:DIP-6047N|refseq:NP_001277006.1|refseq:NP_001277007.1|ensembl:ENSG00000120156(gene)|ensembl:ENST00000380036(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0032878"(regulation of establishment or maintenance of cell polarity)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034451"(centriolar satellite)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051591"(response to cAMP)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072012"(glomerulus vasculature development)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018941|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|mint:Q02763|rcsb pdb:1FVR|rcsb pdb:2GY5|rcsb pdb:2GY7|rcsb pdb:2OO8|rcsb pdb:2OSC|rcsb pdb:2P4I|rcsb pdb:2WQB|rcsb pdb:3BEA|rcsb pdb:3L8P|rcsb pdb:4K0V|rcsb pdb:4X3J|rcsb pdb:5MYA|rcsb pdb:5MYB|rcsb pdb:5UTK|rcsb pdb:6MWE|reactome:R-HSA-210993|reactome:R-HSA-5673001	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1C.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	rogid:JepnLuARYPv22/8BkvefyalSJks10090	rogid:iZHZ6RvLXT65o6FTQaHW+cnrX1o9606	intact-crc:E0328931C1982990|rigid:/A/uLZl7gyHmdoSCX8nlfnSNIC8	false	flag tag:?-?	sufficient binding region:1-348|tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q15389	uniprotkb:Q02763	intact:EBI-2922365|ensembl:ENSP00000428340|uniprotkb:Q5HYA0	intact:EBI-2257090|uniprotkb:A8K6W0|uniprotkb:Q5TCU2|uniprotkb:B4DH20|uniprotkb:B4DHD3|uniprotkb:E7EWI2|uniprotkb:Q8IV34|uniprotkb:D3DRK5|ensembl:ENSP00000369375	psi-mi:angp1_human(display_long)|uniprotkb:ANGPT1(gene name)|psi-mi:ANGPT1(display_short)|uniprotkb:KIAA0003(gene name synonym)	psi-mi:tie2_human(display_long)|uniprotkb:TEK(gene name)|psi-mi:TEK(display_short)|uniprotkb:TIE2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TIE-2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TEK(gene name synonym)|uniprotkb:Tunica interna endothelial cell kinase(gene name synonym)|uniprotkb:p140 TEK(gene name synonym)|uniprotkb:Endothelial tyrosine kinase(gene name synonym)|uniprotkb:Tyrosine kinase with Ig and EGF homology domains-2(gene name synonym)|uniprotkb:VMCM(gene name synonym)|uniprotkb:VMCM1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2922543|imex:IM-15198-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000154188(gene)|ensembl:ENST00000517746(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007171"(activation of transmembrane receptor protein tyrosine kinase activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014842"(regulation of skeletal muscle satellite cell proliferation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030210"(heparin biosynthetic process)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072012"(glomerulus vasculature development)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000446"(regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028843|interpro:IPR036056|mint:Q15389|rcsb pdb:4EPU|rcsb pdb:4JYO|rcsb pdb:4K0V|reactome:R-HSA-210993|reactome:R-HSA-5673001|go:"GO:0031398"(positive regulation of protein ubiquitination)|refseq:NP_001137.2|refseq:NP_001186788.1|refseq:NP_001300980.1	refseq:NP_000450.2|dip:DIP-6047N|refseq:NP_001277006.1|refseq:NP_001277007.1|ensembl:ENSG00000120156(gene)|ensembl:ENST00000380036(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0032878"(regulation of establishment or maintenance of cell polarity)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034451"(centriolar satellite)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051591"(response to cAMP)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072012"(glomerulus vasculature development)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018941|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|mint:Q02763|rcsb pdb:1FVR|rcsb pdb:2GY5|rcsb pdb:2GY7|rcsb pdb:2OO8|rcsb pdb:2OSC|rcsb pdb:2P4I|rcsb pdb:2WQB|rcsb pdb:3BEA|rcsb pdb:3L8P|rcsb pdb:4K0V|rcsb pdb:4X3J|rcsb pdb:5MYA|rcsb pdb:5MYB|rcsb pdb:5UTK|rcsb pdb:6MWE|reactome:R-HSA-210993|reactome:R-HSA-5673001	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1C.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	rogid:UQX0FGhzdmPbYOvuvmXxBdkEgjk9606	rogid:iZHZ6RvLXT65o6FTQaHW+cnrX1o9606	intact-crc:8B058F2D63F71E33|rigid:asHNu9Wui1W0QmJl9yqXA1bA0To	false	flag tag:?-?	sufficient binding region:1-348|tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q02763	uniprotkb:Q9WVH6	intact:EBI-2257090|uniprotkb:A8K6W0|uniprotkb:Q5TCU2|uniprotkb:B4DH20|uniprotkb:B4DHD3|uniprotkb:E7EWI2|uniprotkb:Q8IV34|uniprotkb:D3DRK5|ensembl:ENSP00000369375	intact:EBI-2922406|ensembl:ENSMUSP00000028955	psi-mi:tie2_human(display_long)|uniprotkb:TEK(gene name)|psi-mi:TEK(display_short)|uniprotkb:TIE2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TIE-2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TEK(gene name synonym)|uniprotkb:Tunica interna endothelial cell kinase(gene name synonym)|uniprotkb:p140 TEK(gene name synonym)|uniprotkb:Endothelial tyrosine kinase(gene name synonym)|uniprotkb:Tyrosine kinase with Ig and EGF homology domains-2(gene name synonym)|uniprotkb:VMCM(gene name synonym)|uniprotkb:VMCM1(gene name synonym)	psi-mi:angp4_mouse(display_long)|uniprotkb:Angpt4(gene name)|psi-mi:Angpt4(display_short)|uniprotkb:Agpt4(gene name synonym)|uniprotkb:Ang3(gene name synonym)|uniprotkb:Angiopoietin-3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2922558|imex:IM-15198-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000450.2|dip:DIP-6047N|refseq:NP_001277006.1|refseq:NP_001277007.1|ensembl:ENSG00000120156(gene)|ensembl:ENST00000380036(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0032878"(regulation of establishment or maintenance of cell polarity)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034451"(centriolar satellite)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051591"(response to cAMP)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072012"(glomerulus vasculature development)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018941|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|mint:Q02763|rcsb pdb:1FVR|rcsb pdb:2GY5|rcsb pdb:2GY7|rcsb pdb:2OO8|rcsb pdb:2OSC|rcsb pdb:2P4I|rcsb pdb:2WQB|rcsb pdb:3BEA|rcsb pdb:3L8P|rcsb pdb:4K0V|rcsb pdb:4X3J|rcsb pdb:5MYA|rcsb pdb:5MYB|rcsb pdb:5UTK|rcsb pdb:6MWE|reactome:R-HSA-210993|reactome:R-HSA-5673001	ensembl:ENSMUSG00000027460(gene)|ensembl:ENSMUST00000028955(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007165"(signal transduction)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007492"(endoderm development)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028845|interpro:IPR036056|mint:Q9WVH6|reactome:R-MMU-210993|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|refseq:NP_033771.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1C.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	rogid:iZHZ6RvLXT65o6FTQaHW+cnrX1o9606	rogid:DmktKRZPrgDdIsSFA1eAToNqeog10090	intact-crc:89D8047719A3BA44|rigid:uWKKO/Prjp32bsR4GyIBRSlRWB8	false	sufficient binding region:1-348|tag:c-c	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q02763	uniprotkb:Q9Y264	intact:EBI-2257090|uniprotkb:A8K6W0|uniprotkb:Q5TCU2|uniprotkb:B4DH20|uniprotkb:B4DHD3|uniprotkb:E7EWI2|uniprotkb:Q8IV34|uniprotkb:D3DRK5|ensembl:ENSP00000369375	intact:EBI-2922429|ensembl:ENSP00000371347|uniprotkb:Q5TFF4|uniprotkb:Q9H4Z4|uniprotkb:B4E3J9	psi-mi:tie2_human(display_long)|uniprotkb:TEK(gene name)|psi-mi:TEK(display_short)|uniprotkb:TIE2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TIE-2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TEK(gene name synonym)|uniprotkb:Tunica interna endothelial cell kinase(gene name synonym)|uniprotkb:p140 TEK(gene name synonym)|uniprotkb:Endothelial tyrosine kinase(gene name synonym)|uniprotkb:Tyrosine kinase with Ig and EGF homology domains-2(gene name synonym)|uniprotkb:VMCM(gene name synonym)|uniprotkb:VMCM1(gene name synonym)	psi-mi:angp4_human(display_long)|uniprotkb:ANGPT4(gene name)|psi-mi:ANGPT4(display_short)|uniprotkb:ANG3(gene name synonym)|uniprotkb:ANG4(gene name synonym)|uniprotkb:Angiopoietin-3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2922571|imex:IM-15198-30	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000450.2|dip:DIP-6047N|refseq:NP_001277006.1|refseq:NP_001277007.1|ensembl:ENSG00000120156(gene)|ensembl:ENST00000380036(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0032878"(regulation of establishment or maintenance of cell polarity)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034451"(centriolar satellite)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051591"(response to cAMP)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072012"(glomerulus vasculature development)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018941|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|mint:Q02763|rcsb pdb:1FVR|rcsb pdb:2GY5|rcsb pdb:2GY7|rcsb pdb:2OO8|rcsb pdb:2OSC|rcsb pdb:2P4I|rcsb pdb:2WQB|rcsb pdb:3BEA|rcsb pdb:3L8P|rcsb pdb:4K0V|rcsb pdb:4X3J|rcsb pdb:5MYA|rcsb pdb:5MYB|rcsb pdb:5UTK|rcsb pdb:6MWE|reactome:R-HSA-210993|reactome:R-HSA-5673001	ensembl:ENSG00000101280(gene)|ensembl:ENST00000381922(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0007165"(signal transduction)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028845|interpro:IPR036056|reactome:R-HSA-210993|refseq:NP_057069.1|refseq:NP_001309738.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 1C.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	rogid:iZHZ6RvLXT65o6FTQaHW+cnrX1o9606	rogid:yiz0QDZ2CRrTm/0Khuv1OR2F8Vg9606	intact-crc:8BFF584C92AD9172|rigid:CkUWPOnp8MTntWlUMnIyKE6OLe8	false	sufficient binding region:1-348|tag:c-c	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
intact:EBI-2922463	uniprotkb:P15692-4	-	intact:EBI-1026691|ensembl:ENSP00000429643	psi-mi:vegf_trap(display_short)|psi-mi:EBI-2922463(display_long)	psi-mi:p15692-4(display_long)|uniprotkb:VEGF(isoform synonym)|uniprotkb:VEGFA(gene name)|psi-mi:VEGFA(display_short)|uniprotkb:VEGF(gene name synonym)|uniprotkb:Vascular permeability factor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2922832|imex:IM-15198-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	intact:EBI-1026643(vegfa_human)|ensembl:ENSG00000112715(gene)|ensembl:ENST00000523950(transcript)	psi-mi:"MI:0469"(intact)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Fig S1D.|comment:"The binding affinity of DAAP to VEGF-A is roughly three times lower than that of VEGF-Trap to VEGF-A, whereas the binding affinity of DAAP to Ang-2 is roughly five times higher than that of Tie2-Fc to Ang-2. BIAcore analyses showed similar results (Figure S1D)."|caution:The authors have not confirmed the VEGFA isoform used, nor its origin, nor if VEGFA  is tagged or not.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	-	rogid:/DdgEEe0/rYnemiYvqxeQ+KiXXs9606	intact-crc:5BA89CF987AF8EAC	false	tag:c-c	flag tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-2912164	uniprotkb:P15692-4	-	intact:EBI-1026691|ensembl:ENSP00000429643	psi-mi:daap-5(display_short)|psi-mi:EBI-2912164(display_long)	psi-mi:p15692-4(display_long)|uniprotkb:VEGF(isoform synonym)|uniprotkb:VEGFA(gene name)|psi-mi:VEGFA(display_short)|uniprotkb:VEGF(gene name synonym)|uniprotkb:Vascular permeability factor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2922840|imex:IM-15198-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	intact:EBI-1026643(vegfa_human)|ensembl:ENSG00000112715(gene)|ensembl:ENST00000523950(transcript)	psi-mi:"MI:0469"(intact)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Fig S1D.|comment:"The binding affinity of DAAP to VEGF-A is roughly three times lower than that of VEGF-Trap to VEGF-A, whereas the binding affinity of DAAP to Ang-2 is roughly five times higher than that of Tie2-Fc to Ang-2.  BIAcore analyses showed similar results (Figure S1D)."|caution:The authors have not confirmed the VEGFA isoform used, nor its origin, nor if VEGFA is tagged or not.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	-	rogid:/DdgEEe0/rYnemiYvqxeQ+KiXXs9606	intact-crc:7003BF27107F40F9	false	tag:c-c	flag tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02763	uniprotkb:O15123	intact:EBI-2257090|uniprotkb:A8K6W0|uniprotkb:Q5TCU2|uniprotkb:B4DH20|uniprotkb:B4DHD3|uniprotkb:E7EWI2|uniprotkb:Q8IV34|uniprotkb:D3DRK5|ensembl:ENSP00000369375	intact:EBI-2912111|ensembl:ENSP00000314897|uniprotkb:B7ZLM7|uniprotkb:A0AV38|uniprotkb:A8K205|uniprotkb:Q9NRR7|uniprotkb:Q9P2Y7	psi-mi:tie2_human(display_long)|uniprotkb:TEK(gene name)|psi-mi:TEK(display_short)|uniprotkb:TIE2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TIE-2(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor TEK(gene name synonym)|uniprotkb:Tunica interna endothelial cell kinase(gene name synonym)|uniprotkb:p140 TEK(gene name synonym)|uniprotkb:Endothelial tyrosine kinase(gene name synonym)|uniprotkb:Tyrosine kinase with Ig and EGF homology domains-2(gene name synonym)|uniprotkb:VMCM(gene name synonym)|uniprotkb:VMCM1(gene name synonym)	psi-mi:angp2_human(display_long)|uniprotkb:ANGPT2(gene name)|psi-mi:ANGPT2(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2922848|imex:IM-15198-32	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000450.2|dip:DIP-6047N|refseq:NP_001277006.1|refseq:NP_001277007.1|ensembl:ENSG00000120156(gene)|ensembl:ENST00000380036(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0032878"(regulation of establishment or maintenance of cell polarity)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034451"(centriolar satellite)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051591"(response to cAMP)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072012"(glomerulus vasculature development)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018941|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|mint:Q02763|rcsb pdb:1FVR|rcsb pdb:2GY5|rcsb pdb:2GY7|rcsb pdb:2OO8|rcsb pdb:2OSC|rcsb pdb:2P4I|rcsb pdb:2WQB|rcsb pdb:3BEA|rcsb pdb:3L8P|rcsb pdb:4K0V|rcsb pdb:4X3J|rcsb pdb:5MYA|rcsb pdb:5MYB|rcsb pdb:5UTK|rcsb pdb:6MWE|reactome:R-HSA-210993|reactome:R-HSA-5673001	ensembl:ENSG00000091879(gene)|ensembl:ENST00000325203(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007281"(germ cell development)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0010467"(gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0042995"(cell projection)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0050928"(negative regulation of positive chemotaxis)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0072012"(glomerulus vasculature development)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028844|interpro:IPR036056|rcsb pdb:1Z3S|rcsb pdb:1Z3U|rcsb pdb:4ZFG|rcsb pdb:2GY7|reactome:R-HSA-210993|rcsb pdb:4JZC|refseq:NP_001112359.1|refseq:NP_001112360.1|refseq:NP_001138.1|dip:DIP-6048N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig S1D.|comment:"The binding affinity of DAAP to VEGF-A is roughly three times lower than that of VEGF-Trap to VEGF-A, whereas the binding affinity of DAAP to Ang-2 is roughly five times higher than that of Tie2-Fc to Ang-2. BIAcore analyses showed similar results (Figure S1D)."|caution:The authors have not confirmed the origin of Ang-2, nor  if it is tagged or not.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	rogid:iZHZ6RvLXT65o6FTQaHW+cnrX1o9606	rogid:p1gSsi5cIt3Lp6o5fA4fVAtvZD49606	intact-crc:553BBA502DEBB15F|rigid:mPg1eFmFuJbz1da5Lb+Up2Dm83U	false	tag:c-c|sufficient binding region:122-213	flag tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-2912164	uniprotkb:O15123	-	intact:EBI-2912111|ensembl:ENSP00000314897|uniprotkb:B7ZLM7|uniprotkb:A0AV38|uniprotkb:A8K205|uniprotkb:Q9NRR7|uniprotkb:Q9P2Y7	psi-mi:daap-5(display_short)|psi-mi:EBI-2912164(display_long)	psi-mi:angp2_human(display_long)|uniprotkb:ANGPT2(gene name)|psi-mi:ANGPT2(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Koh et al. (2010)	pubmed:20708158|imex:IM-15198	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2922859|imex:IM-15198-34	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000091879(gene)|ensembl:ENST00000325203(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007281"(germ cell development)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0010467"(gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0042995"(cell projection)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048014"(Tie signaling pathway)|go:"GO:0050928"(negative regulation of positive chemotaxis)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0072012"(glomerulus vasculature development)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028844|interpro:IPR036056|rcsb pdb:1Z3S|rcsb pdb:1Z3U|rcsb pdb:4ZFG|rcsb pdb:2GY7|reactome:R-HSA-210993|rcsb pdb:4JZC|refseq:NP_001112359.1|refseq:NP_001112360.1|refseq:NP_001138.1|dip:DIP-6048N	psi-mi:"MI:0469"(intact)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Fig S1D.|comment:"The binding affinity of DAAP to VEGF-A is roughly three times lower than that of VEGF-Trap to VEGF-A, whereas the binding affinity of DAAP to Ang-2 is roughly five times higher than that of Tie2-Fc to Ang-2. BIAcore analyses showed similar results (Figure S1D)."|caution:The authors have not confirmed the origin of Ang-2, nor  if it is tagged or not.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/02	2014/10/16	-	rogid:p1gSsi5cIt3Lp6o5fA4fVAtvZD49606	intact-crc:EC1CF8409E8B39CD	false	tag:c-c	flag tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)