#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8CBW3	uniprotkb:Q5SQX6	intact:EBI-375511|uniprotkb:Q3U8V0|uniprotkb:Q60747|uniprotkb:Q91ZM5|uniprotkb:Q923I9|uniprotkb:Q99KH4|ensembl:ENSMUSP00000118491	intact:EBI-773783|uniprotkb:Q3UH21|uniprotkb:Q3UHS8|uniprotkb:Q8BSW0|uniprotkb:Q8CHA9|uniprotkb:Q924D3|uniprotkb:Q9R181|ensembl:ENSMUSP00000090853|ensembl:ENSMUSP00000090854|ensembl:ENSMUSP00000127586	psi-mi:abi1_mouse(display_long)|uniprotkb:Abi1(gene name)|psi-mi:Abi1(display_short)|uniprotkb:Ssh3bp1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Ablphilin-1(gene name synonym)	psi-mi:cyfp2_mouse(display_long)|uniprotkb:p53-inducible protein 121(gene name synonym)|uniprotkb:Cyfip2(gene name)|psi-mi:Cyfip2(display_short)|uniprotkb:Kiaa1168(gene name synonym)|uniprotkb:Pir121(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642480|imex:IM-8314-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031406.2|refseq:NP_001070658.1|refseq:NP_001070660.1|refseq:NP_001070661.1|ensembl:ENSMUSG00000058835(gene)|ensembl:ENSMUST00000123948(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0031252"(cell leading edge)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043005"(neuron projection)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8CBW3|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29534N	refseq:NP_598530.2|refseq:NP_001239388.1|refseq:NP_001239389.1|dip:DIP-32111N|ensembl:ENSMUSG00000020340(gene)|ensembl:ENSMUST00000093165(transcript)|ensembl:ENSMUST00000093166(transcript)|ensembl:ENSMUST00000165599(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149	psi-mi:"MI:0469"(intact)	-	-	delivery method:Q8CBW3 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:mDXRmY9uUy6POYZDWeVlwDPxAIs10090	rogid:NP2S3AEcTj9DHTiDHEVM51b8jrE10090	intact-crc:9E6DE9FC4172E736|rigid:qDYiLlwmsAOyTZPCJCRq8sPNz7M	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CBW3	uniprotkb:Q8BH43	intact:EBI-375511|uniprotkb:Q3U8V0|uniprotkb:Q60747|uniprotkb:Q91ZM5|uniprotkb:Q923I9|uniprotkb:Q99KH4|ensembl:ENSMUSP00000118491	intact:EBI-643162|ensembl:ENSMUSP00000081263|ensembl:ENSMUSP00000101532	psi-mi:abi1_mouse(display_long)|uniprotkb:Abi1(gene name)|psi-mi:Abi1(display_short)|uniprotkb:Ssh3bp1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Ablphilin-1(gene name synonym)	psi-mi:wasf2_mouse(display_long)|uniprotkb:Protein WAVE-2(gene name synonym)|uniprotkb:Wave2(gene name synonym)|uniprotkb:Wasf2(gene name)|psi-mi:Wasf2(display_short)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642480|imex:IM-8314-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031406.2|refseq:NP_001070658.1|refseq:NP_001070660.1|refseq:NP_001070661.1|ensembl:ENSMUSG00000058835(gene)|ensembl:ENSMUST00000123948(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0031252"(cell leading edge)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043005"(neuron projection)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8CBW3|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29534N	refseq:NP_700472.1|refseq:XP_006538911.1|refseq:XP_006538912.1|refseq:XP_006538913.1|ensembl:ENSMUSG00000028868(gene)|ensembl:ENSMUST00000084241(transcript)|ensembl:ENSMUST00000105912(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031209"(SCAR complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045202"(synapse)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8BH43|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29535N	psi-mi:"MI:0469"(intact)	-	-	delivery method:Q8CBW3 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:mDXRmY9uUy6POYZDWeVlwDPxAIs10090	rogid:uXkOyyt8x6/M/EU/uhIp8/BAc9w10090	intact-crc:9E6DE9FC4172E736|rigid:qDYiLlwmsAOyTZPCJCRq8sPNz7M	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CBW3	uniprotkb:Q8BVQ3	intact:EBI-375511|uniprotkb:Q3U8V0|uniprotkb:Q60747|uniprotkb:Q91ZM5|uniprotkb:Q923I9|uniprotkb:Q99KH4|ensembl:ENSMUSP00000118491	intact:EBI-2642486	psi-mi:abi1_mouse(display_long)|uniprotkb:Abi1(gene name)|psi-mi:Abi1(display_short)|uniprotkb:Ssh3bp1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Ablphilin-1(gene name synonym)	psi-mi:q8bvq3_mouse(display_long)|uniprotkb:Nckap1l(gene name)|psi-mi:Nckap1l(display_short)|uniprotkb:Hem1(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642480|imex:IM-8314-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031406.2|refseq:NP_001070658.1|refseq:NP_001070660.1|refseq:NP_001070661.1|ensembl:ENSMUSG00000058835(gene)|ensembl:ENSMUST00000123948(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0031252"(cell leading edge)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043005"(neuron projection)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8CBW3|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29534N	interpro:IPR019137	psi-mi:"MI:0469"(intact)	-	-	delivery method:Q8CBW3 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:mDXRmY9uUy6POYZDWeVlwDPxAIs10090	rogid:PCkwFuVPb2L6+TJOoLSWFfhgycE10090	intact-crc:9E6DE9FC4172E736|rigid:qDYiLlwmsAOyTZPCJCRq8sPNz7M	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q8CBW3	uniprotkb:Q91VR8	intact:EBI-375511|uniprotkb:Q3U8V0|uniprotkb:Q60747|uniprotkb:Q91ZM5|uniprotkb:Q923I9|uniprotkb:Q99KH4|ensembl:ENSMUSP00000118491	intact:EBI-643491|uniprotkb:Q3TLB8|ensembl:ENSMUSP00000041644	psi-mi:abi1_mouse(display_long)|uniprotkb:Abi1(gene name)|psi-mi:Abi1(display_short)|uniprotkb:Ssh3bp1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Ablphilin-1(gene name synonym)	psi-mi:brk1_mouse(display_long)|uniprotkb:Brk1(gene name)|psi-mi:Brk1(display_short)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642480|imex:IM-8314-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031406.2|refseq:NP_001070658.1|refseq:NP_001070660.1|refseq:NP_001070661.1|ensembl:ENSMUSG00000058835(gene)|ensembl:ENSMUST00000123948(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0031252"(cell leading edge)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043005"(neuron projection)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8CBW3|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29534N	ensembl:ENSMUSG00000033940(gene)|ensembl:ENSMUST00000035725(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007015"(actin filament organization)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048870"(cell motility)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR033378|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|refseq:NP_598698.1	psi-mi:"MI:0469"(intact)	-	-	delivery method:Q8CBW3 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:mDXRmY9uUy6POYZDWeVlwDPxAIs10090	rogid:i3lwUUzuMjLnJpAMYYhOg4YmpVc10090	intact-crc:9E6DE9FC4172E736|rigid:qDYiLlwmsAOyTZPCJCRq8sPNz7M	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y5K6	uniprotkb:P55194	intact:EBI-298152|uniprotkb:A6NL34|uniprotkb:Q5VYA3|uniprotkb:Q9UG97|ensembl:ENSP00000352264	intact:EBI-2642510|uniprotkb:E9QMQ2|uniprotkb:Q99KK8|ensembl:ENSMUSP00000001226|uniprotkb:A2A5V4	psi-mi:cd2ap_human(display_long)|uniprotkb:CD2AP(gene name)|psi-mi:CD2AP(display_short)|uniprotkb:Cas ligand with multiple SH3 domains(gene name synonym)|uniprotkb:Adapter protein CMS(gene name synonym)	psi-mi:3bp1_mouse(display_long)|uniprotkb:Sh3bp1(gene name)|psi-mi:Sh3bp1(display_short)|uniprotkb:3bp1(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642504|imex:IM-8314-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198087(gene)|ensembl:ENST00000359314(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016050"(vesicle organization)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031941"(filamentous actin)|go:"GO:0032911"(negative regulation of transforming growth factor beta1 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048259"(regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|go:"GO:0051301"(cell division)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR028445|interpro:IPR035775|interpro:IPR035776|interpro:IPR035777|interpro:IPR036028|mint:Q9Y5K6|rcsb pdb:2FEI|rcsb pdb:2J6F|rcsb pdb:2J6K|rcsb pdb:2J6O|rcsb pdb:2J7I|rcsb pdb:3AA6|rcsb pdb:3LK4|rcsb pdb:3U23|rcsb pdb:4WCI|rcsb pdb:4X1V|rcsb pdb:7DS6|rcsb pdb:7DS8|reactome:R-HSA-373753|refseq:NP_036252.1|dip:DIP-31807N	ensembl:ENSMUSG00000022436(gene)|ensembl:ENSMUST00000001226(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030215"(semaphorin receptor binding)|go:"GO:0030834"(regulation of actin filament depolymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0046847"(filopodium assembly)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0097178"(ruffle assembly)|interpro:IPR000198(RhoGAP)|interpro:IPR004148(BAR)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR027267|mint:P55194|rcsb pdb:1ABO|reactome:R-MMU-9013149|refseq:NP_001303613.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary table 2, Fig 1 and 2|delivery method:A6NL34 infection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2017/10/30	rogid:T0OYMq1jOCwVMJOxnrPg5Jm4CGw9606	rogid:xZnGbYRBdoFCbDG2oFc9FfUrl1o10090	intact-crc:49702CE5261F8BD5|rigid:6h/0+69PcBgapIu4vODwBiHdPTY	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y5K6	uniprotkb:A2AMW0	intact:EBI-298152|uniprotkb:A6NL34|uniprotkb:Q5VYA3|uniprotkb:Q9UG97|ensembl:ENSP00000352264	intact:EBI-2642525|ensembl:ENSMUSP00000038011	psi-mi:cd2ap_human(display_long)|uniprotkb:CD2AP(gene name)|psi-mi:CD2AP(display_short)|uniprotkb:Cas ligand with multiple SH3 domains(gene name synonym)|uniprotkb:Adapter protein CMS(gene name synonym)	psi-mi:a2amw0_mouse(display_long)|uniprotkb:Capzb(gene name)|psi-mi:Capzb(display_short)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642504|imex:IM-8314-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198087(gene)|ensembl:ENST00000359314(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016050"(vesicle organization)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031941"(filamentous actin)|go:"GO:0032911"(negative regulation of transforming growth factor beta1 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048259"(regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|go:"GO:0051301"(cell division)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR028445|interpro:IPR035775|interpro:IPR035776|interpro:IPR035777|interpro:IPR036028|mint:Q9Y5K6|rcsb pdb:2FEI|rcsb pdb:2J6F|rcsb pdb:2J6K|rcsb pdb:2J6O|rcsb pdb:2J7I|rcsb pdb:3AA6|rcsb pdb:3LK4|rcsb pdb:3U23|rcsb pdb:4WCI|rcsb pdb:4X1V|rcsb pdb:7DS6|rcsb pdb:7DS8|reactome:R-HSA-373753|refseq:NP_036252.1|dip:DIP-31807N	ensembl:ENSMUSG00000028745(gene)|ensembl:ENSMUST00000042675(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0030017"(sarcomere)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0051016"(barbed-end actin filament capping)|interpro:IPR001698(F-actin capping protein, beta subunit)|interpro:IPR019771|interpro:IPR037282|interpro:IPR042276|interpro:IPR043175	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary table 2, Fig 1 and 2|delivery method:A6NL34 infection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2017/10/30	rogid:T0OYMq1jOCwVMJOxnrPg5Jm4CGw9606	rogid:tQNGtRCtn49pchl5Pnxc/gK4x9810090	intact-crc:49702CE5261F8BD5|rigid:6h/0+69PcBgapIu4vODwBiHdPTY	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y5K6	uniprotkb:P47753	intact:EBI-298152|uniprotkb:A6NL34|uniprotkb:Q5VYA3|uniprotkb:Q9UG97|ensembl:ENSP00000352264	intact:EBI-777259|uniprotkb:Q91YN7	psi-mi:cd2ap_human(display_long)|uniprotkb:CD2AP(gene name)|psi-mi:CD2AP(display_short)|uniprotkb:Cas ligand with multiple SH3 domains(gene name synonym)|uniprotkb:Adapter protein CMS(gene name synonym)	psi-mi:caza1_mouse(display_long)|uniprotkb:CapZ alpha-1(gene name synonym)|uniprotkb:Capza1(gene name)|psi-mi:Capza1(display_short)|uniprotkb:Cappa1(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642504|imex:IM-8314-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198087(gene)|ensembl:ENST00000359314(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016050"(vesicle organization)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031941"(filamentous actin)|go:"GO:0032911"(negative regulation of transforming growth factor beta1 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048259"(regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|go:"GO:0051301"(cell division)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR028445|interpro:IPR035775|interpro:IPR035776|interpro:IPR035777|interpro:IPR036028|mint:Q9Y5K6|rcsb pdb:2FEI|rcsb pdb:2J6F|rcsb pdb:2J6K|rcsb pdb:2J6O|rcsb pdb:2J7I|rcsb pdb:3AA6|rcsb pdb:3LK4|rcsb pdb:3U23|rcsb pdb:4WCI|rcsb pdb:4X1V|rcsb pdb:7DS6|rcsb pdb:7DS8|reactome:R-HSA-373753|refseq:NP_036252.1|dip:DIP-31807N	interpro:IPR017865|interpro:IPR002189(F-actin capping protein, alpha subunit)|interpro:IPR042276|interpro:IPR037282|mint:P47753|interpro:IPR042489|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0034329"(cell junction assembly)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0071203"(WASH complex)|reactome:R-MMU-2132295|reactome:R-MMU-3371497|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-879415|reactome:R-MMU-983231	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary table 2, Fig 1 and 2|delivery method:A6NL34 infection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2017/10/30	rogid:T0OYMq1jOCwVMJOxnrPg5Jm4CGw9606	rogid:RHqr2/WSAoIXWooDhXO9/TSiTJ010090	intact-crc:49702CE5261F8BD5|rigid:6h/0+69PcBgapIu4vODwBiHdPTY	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y5K6	uniprotkb:A2A5V3	intact:EBI-298152|uniprotkb:A6NL34|uniprotkb:Q5VYA3|uniprotkb:Q9UG97|ensembl:ENSP00000352264	intact:EBI-2642533|ensembl:ENSMUSP00000052181	psi-mi:cd2ap_human(display_long)|uniprotkb:CD2AP(gene name)|psi-mi:CD2AP(display_short)|uniprotkb:Cas ligand with multiple SH3 domains(gene name synonym)|uniprotkb:Adapter protein CMS(gene name synonym)	psi-mi:a2a5v3_mouse(display_long)|uniprotkb:Sh3bp1(gene name)|psi-mi:Sh3bp1(display_short)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642504|imex:IM-8314-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198087(gene)|ensembl:ENST00000359314(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016050"(vesicle organization)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031941"(filamentous actin)|go:"GO:0032911"(negative regulation of transforming growth factor beta1 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048259"(regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|go:"GO:0051301"(cell division)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR028445|interpro:IPR035775|interpro:IPR035776|interpro:IPR035777|interpro:IPR036028|mint:Q9Y5K6|rcsb pdb:2FEI|rcsb pdb:2J6F|rcsb pdb:2J6K|rcsb pdb:2J6O|rcsb pdb:2J7I|rcsb pdb:3AA6|rcsb pdb:3LK4|rcsb pdb:3U23|rcsb pdb:4WCI|rcsb pdb:4X1V|rcsb pdb:7DS6|rcsb pdb:7DS8|reactome:R-HSA-373753|refseq:NP_036252.1|dip:DIP-31807N	refseq:NP_033190.2|ensembl:ENSMUSG00000022436(gene)|ensembl:ENSMUST00000061239(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR000198(RhoGAP)|interpro:IPR004148(BAR)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR027267	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary table 2, Fig 1 and 2|delivery method:A6NL34 infection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2017/10/30	rogid:T0OYMq1jOCwVMJOxnrPg5Jm4CGw9606	rogid:PEmSdRvlrYZFO2jbprRDCgmFIV410090	intact-crc:49702CE5261F8BD5|rigid:6h/0+69PcBgapIu4vODwBiHdPTY	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y5K6	uniprotkb:P47754	intact:EBI-298152|uniprotkb:A6NL34|uniprotkb:Q5VYA3|uniprotkb:Q9UG97|ensembl:ENSP00000352264	intact:EBI-299188|ensembl:ENSMUSP00000015877	psi-mi:cd2ap_human(display_long)|uniprotkb:CD2AP(gene name)|psi-mi:CD2AP(display_short)|uniprotkb:Cas ligand with multiple SH3 domains(gene name synonym)|uniprotkb:Adapter protein CMS(gene name synonym)	psi-mi:caza2_mouse(display_long)|uniprotkb:Capza2(gene name)|psi-mi:Capza2(display_short)|uniprotkb:Cappa2(gene name synonym)|uniprotkb:CapZ alpha-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642504|imex:IM-8314-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198087(gene)|ensembl:ENST00000359314(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016050"(vesicle organization)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031941"(filamentous actin)|go:"GO:0032911"(negative regulation of transforming growth factor beta1 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048259"(regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|go:"GO:0051301"(cell division)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR028445|interpro:IPR035775|interpro:IPR035776|interpro:IPR035777|interpro:IPR036028|mint:Q9Y5K6|rcsb pdb:2FEI|rcsb pdb:2J6F|rcsb pdb:2J6K|rcsb pdb:2J6O|rcsb pdb:2J7I|rcsb pdb:3AA6|rcsb pdb:3LK4|rcsb pdb:3U23|rcsb pdb:4WCI|rcsb pdb:4X1V|rcsb pdb:7DS6|rcsb pdb:7DS8|reactome:R-HSA-373753|refseq:NP_036252.1|dip:DIP-31807N	ensembl:ENSMUST00000015877(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|interpro:IPR002189(F-actin capping protein, alpha subunit)|interpro:IPR017865|interpro:IPR037282|interpro:IPR042276|interpro:IPR042489|mint:P47754|reactome:R-MMU-2132295|reactome:R-MMU-3371497|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-879415|reactome:R-MMU-983231|ensembl:ENSMUSG00000015733(gene)|refseq:NP_031630.1|dip:DIP-31382N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary table 2, Fig 1 and 2|delivery method:A6NL34 infection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2017/10/30	rogid:T0OYMq1jOCwVMJOxnrPg5Jm4CGw9606	rogid:9nxfEbrpHlDtTYwSvHAJvZLLweo10090	intact-crc:49702CE5261F8BD5|rigid:6h/0+69PcBgapIu4vODwBiHdPTY	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q64010-2	uniprotkb:P00519	intact:EBI-2642543	intact:EBI-375543|uniprotkb:Q13869|uniprotkb:Q13870|uniprotkb:Q16133|uniprotkb:Q45F09|ensembl:ENSP00000323315|uniprotkb:A3KFJ3|uniprotkb:Q17R61|intact:EBI-1550796	psi-mi:q64010-2(display_long)|uniprotkb:Crko(gene name synonym)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:p38(gene name synonym)|uniprotkb:Crk(gene name)|psi-mi:Crk(display_short)	psi-mi:abl1_human(display_long)|uniprotkb:Abelson tyrosine-protein kinase 1(gene name synonym)|uniprotkb:ABL1(gene name)|psi-mi:ABL1(display_short)|uniprotkb:ABL(gene name synonym)|uniprotkb:JTK7(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 1(gene name synonym)|uniprotkb:Proto-oncogene c-Abl(gene name synonym)|uniprotkb:p150(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642542|imex:IM-8314-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2906540(isoform-parent)	refseq:NP_005148.2|refseq:NP_009297.2|ensembl:ENSG00000097007(gene)|ensembl:ENST00000318560(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016301"(kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019905"(syntaxin binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030035"(microspike assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002333"(transitional one stage B cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004515"(nicotinate-nucleotide adenylyltransferase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0038191"(neuropilin binding)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048668"(collateral sprouting)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071103"(DNA conformation change)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072359"(circulatory system development)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090135"(actin filament branching)|go:"GO:0098794"(postsynapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900275"(negative regulation of phospholipase C activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1903053"(regulation of extracellular matrix organization)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015015(F-actin binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR033221|interpro:IPR035837|interpro:IPR036028|interpro:IPR036860|mint:P00519|rcsb pdb:1AB2|rcsb pdb:1ABL|rcsb pdb:2HIW|rcsb pdb:2HYY|rcsb pdb:2HZ0|rcsb pdb:2HZ4|rcsb pdb:2HZI|rcsb pdb:2O88|rcsb pdb:2V7A|rcsb pdb:3CS9|rcsb pdb:3EG0|rcsb pdb:3EG1|rcsb pdb:3EG2|rcsb pdb:3EG3|rcsb pdb:3EGU|rcsb pdb:3K2M|rcsb pdb:3PYY|rcsb pdb:3QRI|rcsb pdb:3QRJ|rcsb pdb:3QRK|rcsb pdb:3T04|rcsb pdb:3UE4|rcsb pdb:3UYO|rcsb pdb:4J9B|rcsb pdb:4J9C|rcsb pdb:4J9D|rcsb pdb:1AWO|rcsb pdb:1BBZ|rcsb pdb:1JU5|rcsb pdb:1OPL|rcsb pdb:1ZZP|rcsb pdb:2ABL|rcsb pdb:2E2B|rcsb pdb:2F4J|rcsb pdb:2FO0|rcsb pdb:4J9E|rcsb pdb:2G1T|rcsb pdb:4J9F|rcsb pdb:2G2F|rcsb pdb:2G2H|rcsb pdb:4J9G|rcsb pdb:2G2I|rcsb pdb:4J9H|rcsb pdb:2GQG|rcsb pdb:4J9I|rcsb pdb:4JJB|rcsb pdb:4JJC|rcsb pdb:4JJD|rcsb pdb:4TWP|rcsb pdb:4WA9|rcsb pdb:4XEY|rcsb pdb:4YC8|rcsb pdb:4ZOG|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5HU9|rcsb pdb:5MO4|rcsb pdb:5NP2|rcsb pdb:5OAZ|rcsb pdb:6AMV|rcsb pdb:6AMW|rcsb pdb:6BL8|rcsb pdb:6NPE|rcsb pdb:6NPU|rcsb pdb:6NPV|rcsb pdb:6XR6|rcsb pdb:6XR7|rcsb pdb:6XRG|rcsb pdb:7CC2|rcsb pdb:7DT2|reactome:R-HSA-2029482|reactome:R-HSA-428890|reactome:R-HSA-525793|reactome:R-HSA-5663213|reactome:R-HSA-5685938|reactome:R-HSA-5693565|reactome:R-HSA-69231|reactome:R-HSA-8939236|reactome:R-HSA-8940973|reactome:R-HSA-9664422|reactome:R-HSA-983231|dip:DIP-1042N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary table 2, Fig 1 and 2|delivery method:Q64010-2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2018/07/23	rogid:dIw6tL6/04Oz9n0rUTH2MoTCRG810090	rogid:t7dT+fWrrK2QaWF4U0HQaVgHKUc9606	intact-crc:7B604797A0C4C9F6|rigid:nUMrPclmP23fG7Q8QrShSwFj6DY	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q64010-2	uniprotkb:P11274	intact:EBI-2642543	intact:EBI-712838|intact:EBI-28971369|ensembl:ENSP00000303507|uniprotkb:P78501|uniprotkb:Q12842|uniprotkb:Q4LE80|uniprotkb:Q6NZI3	psi-mi:q64010-2(display_long)|uniprotkb:Crko(gene name synonym)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:p38(gene name synonym)|uniprotkb:Crk(gene name)|psi-mi:Crk(display_short)	psi-mi:bcr_human(display_long)|uniprotkb:Renal carcinoma antigen NY-REN-26(gene name synonym)|uniprotkb:BCR(gene name)|psi-mi:BCR(display_short)|uniprotkb:BCR1(gene name synonym)|uniprotkb:D22S11(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642542|imex:IM-8314-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2906540(isoform-parent)	ensembl:ENSG00000186716(gene)|ensembl:ENST00000305877(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030424"(axon)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0043197"(dendritic spine)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000198(RhoGAP)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR015123(Bcr-Abl oncoprotein oligomerisation)|interpro:IPR035892|interpro:IPR035899|interpro:IPR036481|interpro:IPR037769|rcsb pdb:1K1F|rcsb pdb:2AIN|rcsb pdb:5N6R|rcsb pdb:5N7E|rcsb pdb:5OC7|reactome:R-HSA-1839117|reactome:R-HSA-5655302|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|mint:P11274|ensembl:ENSP00000303507|ensembl:ENST00000359540|ensembl:ENSP00000352535|refseq:NP_004318.3|refseq:NP_067585.2	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary table 2, Fig 1 and 2|delivery method:Q64010-2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2018/07/23	rogid:dIw6tL6/04Oz9n0rUTH2MoTCRG810090	rogid:U2+lPQ5c2dVW2MPLvknA0Bbg4fA9606	intact-crc:7B604797A0C4C9F6|rigid:nUMrPclmP23fG7Q8QrShSwFj6DY	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q64010-2	uniprotkb:Q91ZZ2	intact:EBI-2642543	intact:EBI-644719|ensembl:ENSMUSP00000099936	psi-mi:q64010-2(display_long)|uniprotkb:Crko(gene name synonym)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:p38(gene name synonym)|uniprotkb:Crk(gene name)|psi-mi:Crk(display_short)	psi-mi:q91zz2_mouse(display_long)|uniprotkb:Rapgef1(gene name)|psi-mi:Rapgef1(display_short)|uniprotkb:Grf2(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642542|imex:IM-8314-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2906540(isoform-parent)	refseq:NP_473391.1|ensembl:ENSMUSG00000039844(gene)|ensembl:ENSMUST00000102872(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR019804|interpro:IPR023578|interpro:IPR036964	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary table 2, Fig 1 and 2|delivery method:Q64010-2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2018/07/23	rogid:dIw6tL6/04Oz9n0rUTH2MoTCRG810090	rogid:heLCxkFCi/GUrFw2EdEUUd7yQS010090	intact-crc:7B604797A0C4C9F6|rigid:nUMrPclmP23fG7Q8QrShSwFj6DY	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q64010-2	uniprotkb:P22682	intact:EBI-2642543	intact:EBI-640919|intact:EBI-2642588|uniprotkb:Q3U527|ensembl:ENSMUSP00000146244|uniprotkb:Q8CEA1	psi-mi:q64010-2(display_long)|uniprotkb:Crko(gene name synonym)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:p38(gene name synonym)|uniprotkb:Crk(gene name)|psi-mi:Crk(display_short)	psi-mi:cbl_mouse(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:Cbl(gene name)|psi-mi:Cbl(display_short)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642542|imex:IM-8314-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2906540(isoform-parent)	interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22682|rcsb pdb:2D9S|reactome:R-MMU-1059683|reactome:R-MMU-1295596|reactome:R-MMU-1433559|reactome:R-MMU-182971|reactome:R-MMU-2173789|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-6807004|reactome:R-MMU-8849469|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-912631|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045453"(bone resorption)|go:"GO:0045471"(response to ethanol)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR024162|reactome:R-MMU-9706369|ensembl:ENSMUSG00000034342(gene)|ensembl:ENSMUST00000206720(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|refseq:NP_031645.2|dip:DIP-33472N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary table 2, Fig 1 and 2|delivery method:Q64010-2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2018/07/23	rogid:dIw6tL6/04Oz9n0rUTH2MoTCRG810090	rogid:8MpthfXwJFMSMC6mDaTdb063dj010090	intact-crc:7B604797A0C4C9F6|rigid:nUMrPclmP23fG7Q8QrShSwFj6DY	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q64010-2	uniprotkb:Q571I4	intact:EBI-2642543	intact:EBI-2642562|uniprotkb:Q8CB68|ensembl:ENSMUSP00000106118|uniprotkb:E9QLH9	psi-mi:q64010-2(display_long)|uniprotkb:Crko(gene name synonym)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:p38(gene name synonym)|uniprotkb:Crk(gene name)|psi-mi:Crk(display_short)	psi-mi:prag1_mouse(display_long)|uniprotkb:D8Ertd82e(gene name synonym)|uniprotkb:Nack(gene name synonym)|uniprotkb:Notch activation complex kinase(gene name synonym)|uniprotkb:Prag1(gene name)|psi-mi:Prag1(display_short)|uniprotkb:Sgk223(gene name synonym)|uniprotkb:Sugen kinase 223(gene name synonym)|uniprotkb:Tyrosine-protein kinase SgK223(gene name synonym)|uniprotkb:PEAK1-related kinase-activating pseudokinase 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642542|imex:IM-8314-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2906540(isoform-parent)	refseq:NP_766499.2|refseq:XP_011240439.1|ensembl:ENSMUSG00000050271(gene)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008266(Tyrosine protein kinase, active site)|ensembl:ENSMUST00000110492(transcript)|interpro:IPR011009(Protein kinase-like)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016477"(cell migration)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:2000145"(regulation of cell motility)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary table 2, Fig 1 and 2|delivery method:Q64010-2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2018/07/23	rogid:dIw6tL6/04Oz9n0rUTH2MoTCRG810090	rogid:YHeN6FfRpyIpxIHxiLzjjINANbw10090	intact-crc:7B604797A0C4C9F6|rigid:nUMrPclmP23fG7Q8QrShSwFj6DY	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q64010-2	uniprotkb:P26450	intact:EBI-2642543	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	psi-mi:q64010-2(display_long)|uniprotkb:Crko(gene name synonym)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:p38(gene name synonym)|uniprotkb:Crk(gene name)|psi-mi:Crk(display_short)	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642542|imex:IM-8314-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2906540(isoform-parent)	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary table 2, Fig 1 and 2|delivery method:Q64010-2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2018/07/23	rogid:dIw6tL6/04Oz9n0rUTH2MoTCRG810090	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	intact-crc:7B604797A0C4C9F6|rigid:nUMrPclmP23fG7Q8QrShSwFj6DY	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q64010-2	uniprotkb:Q8BTI9	intact:EBI-2642543	intact:EBI-644672|uniprotkb:Q3U4Q1|ensembl:ENSMUSP00000035037	psi-mi:q64010-2(display_long)|uniprotkb:Crko(gene name synonym)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:p38(gene name synonym)|uniprotkb:Crk(gene name)|psi-mi:Crk(display_short)	psi-mi:pk3cb_mouse(display_long)|uniprotkb:Pik3cb(gene name)|psi-mi:Pik3cb(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642542|imex:IM-8314-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2906540(isoform-parent)	refseq:NP_083370.2|refseq:XP_011241131.1|refseq:XP_011241132.1|ensembl:ENSMUSG00000032462(gene)|ensembl:ENSMUST00000035037(transcript)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009611"(response to wounding)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0030496"(midbody)|go:"GO:0031526"(brush border membrane)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037702|interpro:IPR042236|rcsb pdb:2Y3A|rcsb pdb:4BFR|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-109704|dip:DIP-49395N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary table 2, Fig 1 and 2|delivery method:Q64010-2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2018/07/23	rogid:dIw6tL6/04Oz9n0rUTH2MoTCRG810090	rogid:DJ0wDyQPs055TTumVtx6c2BqyMU10090	intact-crc:7B604797A0C4C9F6|rigid:nUMrPclmP23fG7Q8QrShSwFj6DY	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q64010-2	uniprotkb:O08908	intact:EBI-2642543	intact:EBI-643570|ensembl:ENSMUSP00000034296|uniprotkb:Q5U3K7	psi-mi:q64010-2(display_long)|uniprotkb:Crko(gene name synonym)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:p38(gene name synonym)|uniprotkb:Crk(gene name)|psi-mi:Crk(display_short)	psi-mi:p85b_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)|uniprotkb:Pik3r2(gene name)|psi-mi:Pik3r2(display_short)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642542|imex:IM-8314-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2906540(isoform-parent)	ensembl:ENSMUSG00000031834(gene)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|ensembl:ENSMUST00000034296(transcript)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005925"(focal adhesion)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0030971"(receptor tyrosine kinase binding)|refseq:NP_032867.2|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|rcsb pdb:2Y3A|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-6811558|reactome:R-MMU-512988|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9696264|reactome:R-MMU-5673001|reactome:R-MMU-9696270|reactome:R-MMU-9696273	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary table 2, Fig 1 and 2|delivery method:Q64010-2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2018/07/23	rogid:dIw6tL6/04Oz9n0rUTH2MoTCRG810090	rogid:8SNYg9Yr1SPNGhxsho1rANQT/Ks10090	intact-crc:7B604797A0C4C9F6|rigid:nUMrPclmP23fG7Q8QrShSwFj6DY	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q64010-1	uniprotkb:O08908	intact:EBI-2642597|ensembl:ENSMUSP00000017920	intact:EBI-643570|ensembl:ENSMUSP00000034296|uniprotkb:Q5U3K7	psi-mi:q64010-1(display_long)|uniprotkb:Crko(gene name synonym)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:p38(gene name synonym)|uniprotkb:Crk(gene name)|psi-mi:Crk(display_short)	psi-mi:p85b_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)|uniprotkb:Pik3r2(gene name)|psi-mi:Pik3r2(display_short)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642625|imex:IM-8314-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2906540(isoform-parent)|ensembl:ENSMUSG00000017776(gene)|ensembl:ENSMUST00000017920(transcript)	ensembl:ENSMUSG00000031834(gene)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|ensembl:ENSMUST00000034296(transcript)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005925"(focal adhesion)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0030971"(receptor tyrosine kinase binding)|refseq:NP_032867.2|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|rcsb pdb:2Y3A|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-6811558|reactome:R-MMU-512988|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9696264|reactome:R-MMU-5673001|reactome:R-MMU-9696270|reactome:R-MMU-9696273	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary table 2, Fig 1 and 2|delivery method:Q64010-1 infection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:e9eU7+wkCP5FNnenBlIixVbL7UM10090	rogid:8SNYg9Yr1SPNGhxsho1rANQT/Ks10090	intact-crc:45287C1A186CE210|rigid:hP3lsW8Au83kXg0v7i9ar1HL1xg	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q64010-1	uniprotkb:O88398	intact:EBI-2642597|ensembl:ENSMUSP00000017920	intact:EBI-2642620|uniprotkb:Q3U1K5|uniprotkb:O70466|ensembl:ENSMUSP00000026500|ensembl:ENSMUSP00000123405	psi-mi:q64010-1(display_long)|uniprotkb:Crko(gene name synonym)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:p38(gene name synonym)|uniprotkb:Crk(gene name)|psi-mi:Crk(display_short)	psi-mi:avil_mouse(display_long)|uniprotkb:Advil(gene name synonym)|uniprotkb:Actin-binding protein DOC6(gene name synonym)|uniprotkb:p92(gene name synonym)|uniprotkb:Avil(gene name)|psi-mi:Avil(display_short)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642625|imex:IM-8314-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2906540(isoform-parent)|ensembl:ENSMUSG00000017776(gene)|ensembl:ENSMUST00000017920(transcript)	refseq:NP_033765.2|ensembl:ENSMUSG00000025432(gene)|ensembl:ENSMUST00000026500(transcript)|ensembl:ENSMUST00000129173(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005884"(actin filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007399"(nervous system development)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0060271"(cilium assembly)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:1900480"(regulation of diacylglycerol biosynthetic process)|interpro:IPR003128(Villin headpiece)|interpro:IPR007122(Gelsolin)|interpro:IPR007123(Gelsolin region)|interpro:IPR029006|interpro:IPR036180|interpro:IPR036886|go:"GO:0015629"(actin cytoskeleton)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary table 2, Fig 1 and 2|delivery method:Q64010-1 infection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:e9eU7+wkCP5FNnenBlIixVbL7UM10090	rogid:k5OFzpHtgC8RkIeIMtf1RAfnuoc10090	intact-crc:45287C1A186CE210|rigid:hP3lsW8Au83kXg0v7i9ar1HL1xg	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q64010-1	uniprotkb:Q9CQV8	intact:EBI-2642597|ensembl:ENSMUSP00000017920	intact:EBI-771608|uniprotkb:O70455|uniprotkb:Q3TY33|uniprotkb:Q3UAN6|ensembl:ENSMUSP00000018470	psi-mi:q64010-1(display_long)|uniprotkb:Crko(gene name synonym)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:p38(gene name synonym)|uniprotkb:Crk(gene name)|psi-mi:Crk(display_short)	psi-mi:1433b_mouse(display_long)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:Ywhab(gene name)|psi-mi:Ywhab(display_short)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642625|imex:IM-8314-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2906540(isoform-parent)|ensembl:ENSMUSG00000017776(gene)|ensembl:ENSMUST00000017920(transcript)	refseq:NP_061223.2|refseq:XP_006499972.1|reactome:R-MMU-111447|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-170968|reactome:R-MMU-2028269|reactome:R-MMU-392517|reactome:R-MMU-450385|reactome:R-MMU-450513|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5675221|reactome:R-MMU-75035|reactome:R-MMU-9614399|ensembl:ENSMUSG00000018326(gene)|ensembl:ENSMUST00000018470(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|rcsb pdb:4GNT|rcsb pdb:5F74|rcsb pdb:5WFU|rcsb pdb:5WFX	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary table 2, Fig 1 and 2|delivery method:Q64010-1 infection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:e9eU7+wkCP5FNnenBlIixVbL7UM10090	rogid:g94luGOxfq+Jbi0ztZ7gbAkp+2A10090	intact-crc:45287C1A186CE210|rigid:hP3lsW8Au83kXg0v7i9ar1HL1xg	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q64010-1	uniprotkb:P22682	intact:EBI-2642597|ensembl:ENSMUSP00000017920	intact:EBI-640919|intact:EBI-2642588|uniprotkb:Q3U527|ensembl:ENSMUSP00000146244|uniprotkb:Q8CEA1	psi-mi:q64010-1(display_long)|uniprotkb:Crko(gene name synonym)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:p38(gene name synonym)|uniprotkb:Crk(gene name)|psi-mi:Crk(display_short)	psi-mi:cbl_mouse(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:Cbl(gene name)|psi-mi:Cbl(display_short)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642625|imex:IM-8314-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2906540(isoform-parent)|ensembl:ENSMUSG00000017776(gene)|ensembl:ENSMUST00000017920(transcript)	interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22682|rcsb pdb:2D9S|reactome:R-MMU-1059683|reactome:R-MMU-1295596|reactome:R-MMU-1433559|reactome:R-MMU-182971|reactome:R-MMU-2173789|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-6807004|reactome:R-MMU-8849469|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-912631|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045453"(bone resorption)|go:"GO:0045471"(response to ethanol)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR024162|reactome:R-MMU-9706369|ensembl:ENSMUSG00000034342(gene)|ensembl:ENSMUST00000206720(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|refseq:NP_031645.2|dip:DIP-33472N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary table 2, Fig 1 and 2|delivery method:Q64010-1 infection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:e9eU7+wkCP5FNnenBlIixVbL7UM10090	rogid:8MpthfXwJFMSMC6mDaTdb063dj010090	intact-crc:45287C1A186CE210|rigid:hP3lsW8Au83kXg0v7i9ar1HL1xg	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q64010-1	uniprotkb:Q9QXS1	intact:EBI-2642597|ensembl:ENSMUSP00000017920	intact:EBI-774583|uniprotkb:Q9QXR8|uniprotkb:Q9QXR9|uniprotkb:Q6S384|uniprotkb:Q6S389|uniprotkb:Q6S394|uniprotkb:Q9CS65|uniprotkb:Q9QUT2|uniprotkb:Q9QXQ8|uniprotkb:Q9QXQ9|uniprotkb:Q9QXR0|uniprotkb:Q9QXR1|uniprotkb:Q9QXR2|uniprotkb:Q9QXR3|uniprotkb:Q9QXR4|uniprotkb:Q9QXR5|uniprotkb:Q9QXR6|uniprotkb:Q9QXR7|uniprotkb:Q9QXS0|uniprotkb:Q9QXS2|uniprotkb:Q9QXS3|uniprotkb:E9QN87|ensembl:ENSMUSP00000073124	psi-mi:q64010-1(display_long)|uniprotkb:Crko(gene name synonym)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:p38(gene name synonym)|uniprotkb:Crk(gene name)|psi-mi:Crk(display_short)	psi-mi:plec_mouse(display_long)|uniprotkb:Plectin-6(gene name synonym)|uniprotkb:Plec(gene name)|psi-mi:Plec(display_short)|uniprotkb:Plec1(gene name synonym)|uniprotkb:Plectin-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642625|imex:IM-8314-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2906540(isoform-parent)|ensembl:ENSMUSG00000017776(gene)|ensembl:ENSMUST00000017920(transcript)	refseq:NP_001157012.1|refseq:NP_001157014.1|refseq:NP_001157021.1|refseq:NP_001157675.1|refseq:NP_035247.2|refseq:NP_958791.2|refseq:NP_958796.2|dip:DIP-32004N|ensembl:ENSMUSG00000022565(gene)|ensembl:ENSMUST00000073418(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0002522"(leukocyte migration involved in immune response)|go:"GO:0003334"(keratinocyte development)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006997"(nucleus organization)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007584"(response to nutrient)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010467"(gene expression)|go:"GO:0010761"(fibroblast migration)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0014866"(skeletal myofibril assembly)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016528"(sarcoplasm)|go:"GO:0016569"(obsolete covalent chromatin modification)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030016"(myofibril)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032094"(response to food)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042060"(wound healing)|go:"GO:0042383"(sarcolemma)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043209"(myelin sheath)|go:"GO:0043292"(contractile fiber)|go:"GO:0043588"(skin development)|go:"GO:0043621"(protein self-association)|go:"GO:0043933"(protein-containing complex organization)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048870"(cell motility)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071944"(cell periphery)|go:"GO:0120193"(tight junction organization)|go:"GO:2000689"(actomyosin contractile ring assembly actin filament organization)|go:"GO:2000983"(regulation of ATP citrate synthase activity)|interpro:IPR001101(Plectin repeat)|interpro:IPR001452(Src homology-3)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR005326(Plectin/S10, N-terminal)|interpro:IPR018159|interpro:IPR030269|interpro:IPR035915|interpro:IPR036388|interpro:IPR036872|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197|mint:Q9QXS1|rcsb pdb:1SH5|rcsb pdb:1SH6|rcsb pdb:4Q57|reactome:R-MMU-264870|reactome:R-MMU-446107	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary table 2, Fig 1 and 2|delivery method:Q64010-1 infection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:e9eU7+wkCP5FNnenBlIixVbL7UM10090	rogid:9cGCRGhjImLIGd9shNPJRdSpdoY10090	intact-crc:45287C1A186CE210|rigid:hP3lsW8Au83kXg0v7i9ar1HL1xg	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q64010-1	uniprotkb:P68510	intact:EBI-2642597|ensembl:ENSMUSP00000017920	intact:EBI-444641|uniprotkb:P11576|uniprotkb:P70198|uniprotkb:Q3TGZ9|ensembl:ENSMUSP00000019109	psi-mi:q64010-1(display_long)|uniprotkb:Crko(gene name synonym)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:p38(gene name synonym)|uniprotkb:Crk(gene name)|psi-mi:Crk(display_short)	psi-mi:1433f_mouse(display_long)|uniprotkb:Ywhah(gene name)|psi-mi:Ywhah(display_short)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642625|imex:IM-8314-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2906540(isoform-parent)|ensembl:ENSMUSG00000017776(gene)|ensembl:ENSMUST00000017920(transcript)	refseq:NP_035868.1|ensembl:ENSMUSG00000018965(gene)|ensembl:ENSMUST00000019109(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006713"(glucocorticoid catabolic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0014704"(intercalated disc)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P68510|rcsb pdb:5YQG|go:"GO:0006886"(intracellular protein transport)|reactome:R-MMU-111447|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary table 2, Fig 1 and 2|delivery method:Q64010-1 infection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:e9eU7+wkCP5FNnenBlIixVbL7UM10090	rogid:Ew2uUYIXrZ8nnP52xMnGB6KOCqc10090	intact-crc:45287C1A186CE210|rigid:hP3lsW8Au83kXg0v7i9ar1HL1xg	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q64010-1	uniprotkb:P63101	intact:EBI-2642597|ensembl:ENSMUSP00000017920	intact:EBI-354751|uniprotkb:P35215|uniprotkb:P70197|uniprotkb:P97286|uniprotkb:Q3TSF1|uniprotkb:Q5EBQ1|ensembl:ENSMUSP00000022894|ensembl:ENSMUSP00000105990|ensembl:ENSMUSP00000105991	psi-mi:q64010-1(display_long)|uniprotkb:Crko(gene name synonym)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:p38(gene name synonym)|uniprotkb:Crk(gene name)|psi-mi:Crk(display_short)	psi-mi:1433z_mouse(display_long)|uniprotkb:Ywhaz(gene name)|psi-mi:Ywhaz(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:SEZ-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642625|imex:IM-8314-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2906540(isoform-parent)|ensembl:ENSMUSG00000017776(gene)|ensembl:ENSMUST00000017920(transcript)	refseq:NP_001240734.1|refseq:NP_001240735.1|refseq:NP_035870.1|refseq:XP_011243654.1|ensembl:ENSMUSG00000022285(gene)|ensembl:ENSMUST00000110361(transcript)|ensembl:ENSMUST00000110362(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0003016"(respiratory system process)|ensembl:ENSMUST00000022894(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0010941"(regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035148"(tube formation)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P63101|reactome:R-MMU-111447|reactome:R-MMU-3769402|reactome:R-MMU-392517|reactome:R-MMU-430116|reactome:R-MMU-450604|reactome:R-MMU-512988|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9013700|reactome:R-MMU-9614399|dip:DIP-31894N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary table 2, Fig 1 and 2|delivery method:Q64010-1 infection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:e9eU7+wkCP5FNnenBlIixVbL7UM10090	rogid:v2N95HO8sYRWEg2gFtWiYajP1Sc10090	intact-crc:45287C1A186CE210|rigid:hP3lsW8Au83kXg0v7i9ar1HL1xg	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q64010-1	uniprotkb:P68254	intact:EBI-2642597|ensembl:ENSMUSP00000017920	intact:EBI-400675|uniprotkb:P35216|uniprotkb:Q3TW69|uniprotkb:Q3UJN5|uniprotkb:Q5SP76|uniprotkb:Q5U423|uniprotkb:Q66JR6|ensembl:ENSMUSP00000100067|ensembl:ENSMUSP00000123605	psi-mi:q64010-1(display_long)|uniprotkb:Crko(gene name synonym)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:p38(gene name synonym)|uniprotkb:Crk(gene name)|psi-mi:Crk(display_short)	psi-mi:1433t_mouse(display_long)|uniprotkb:Ywhaq(gene name)|psi-mi:Ywhaq(display_short)|uniprotkb:14-3-3 protein tau(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642625|imex:IM-8314-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2906540(isoform-parent)|ensembl:ENSMUSG00000017776(gene)|ensembl:ENSMUST00000017920(transcript)	refseq:NP_035869.1|ensembl:ENSMUSG00000076432(gene)|ensembl:ENSMUST00000103002(transcript)|ensembl:ENSMUST00000135088(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034766"(negative regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR042584|mint:P68254|reactome:R-MMU-111447|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9614399	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary table 2, Fig 1 and 2|delivery method:Q64010-1 infection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:e9eU7+wkCP5FNnenBlIixVbL7UM10090	rogid:l8bki6QJJEH5S5NIwQdm/MAYcc010090	intact-crc:45287C1A186CE210|rigid:hP3lsW8Au83kXg0v7i9ar1HL1xg	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q64010-1	uniprotkb:P61982	intact:EBI-2642597|ensembl:ENSMUSP00000017920	intact:EBI-359843|uniprotkb:O70457|uniprotkb:P35214|uniprotkb:Q4FK44|uniprotkb:Q3UFD6|uniprotkb:Q9UDP2|uniprotkb:Q9UN99|ensembl:ENSMUSP00000051223|ensembl:ENSMUSP00000143631	psi-mi:q64010-1(display_long)|uniprotkb:Crko(gene name synonym)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:p38(gene name synonym)|uniprotkb:Crk(gene name)|psi-mi:Crk(display_short)	psi-mi:1433g_mouse(display_long)|uniprotkb:Ywhag(gene name)|psi-mi:Ywhag(display_short)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642625|imex:IM-8314-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2906540(isoform-parent)|ensembl:ENSMUSG00000017776(gene)|ensembl:ENSMUST00000017920(transcript)	refseq:NP_061359.2|ensembl:ENSMUSG00000051391(gene)|ensembl:ENSMUST00000055808(transcript)|ensembl:ENSMUST00000198270(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0098793"(presynapse)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P61982|reactome:R-MMU-111447|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-8854518|reactome:R-MMU-9614399	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary table 2, Fig 1 and 2|delivery method:Q64010-1 infection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:e9eU7+wkCP5FNnenBlIixVbL7UM10090	rogid:u1cd71h0RPgTOEMrQVhOelsxWnM10090	intact-crc:45287C1A186CE210|rigid:hP3lsW8Au83kXg0v7i9ar1HL1xg	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q64010-1	uniprotkb:P62259	intact:EBI-2642597|ensembl:ENSMUSP00000017920	intact:EBI-356480|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q63631|ensembl:ENSMUSP00000070993	psi-mi:q64010-1(display_long)|uniprotkb:Crko(gene name synonym)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:p38(gene name synonym)|uniprotkb:Crk(gene name)|psi-mi:Crk(display_short)	psi-mi:1433e_mouse(display_long)|uniprotkb:Ywhae(gene name)|psi-mi:Ywhae(display_short)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642625|imex:IM-8314-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2906540(isoform-parent)|ensembl:ENSMUSG00000017776(gene)|ensembl:ENSMUST00000017920(transcript)	ensembl:ENSMUSG00000020849(gene)|ensembl:ENSMUST00000067664(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001764"(neuron migration)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0006605"(protein targeting)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|refseq:NP_033562.3|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62259|reactome:R-MMU-111447|reactome:R-MMU-2028269|reactome:R-MMU-205025|reactome:R-MMU-2565942|reactome:R-MMU-3371453|reactome:R-MMU-3371511|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-8854518|reactome:R-MMU-8876198	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary table 2, Fig 1 and 2|delivery method:Q64010-1 infection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:e9eU7+wkCP5FNnenBlIixVbL7UM10090	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ10090	intact-crc:45287C1A186CE210|rigid:hP3lsW8Au83kXg0v7i9ar1HL1xg	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P47941	uniprotkb:P35700	intact:EBI-2642655|uniprotkb:Q8BGC5|uniprotkb:Q3TQ18|ensembl:ENSMUSP00000006293	intact:EBI-444948|uniprotkb:Q3UBV4|uniprotkb:Q9CWI2|ensembl:ENSMUSP00000102078|ensembl:ENSMUSP00000114159	psi-mi:crkl_mouse(display_long)|uniprotkb:Crkol(gene name synonym)|uniprotkb:Crkl(gene name)|psi-mi:Crkl(display_short)	psi-mi:prdx1_mouse(display_long)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 2(gene name synonym)|uniprotkb:Osteoblast-specific factor 3(gene name synonym)|uniprotkb:Macrophage 23 kDa stress protein(gene name synonym)|uniprotkb:Thioredoxin peroxidase 2(gene name synonym)|uniprotkb:Prdx1(gene name)|psi-mi:Prdx1(display_short)|uniprotkb:Msp23(gene name synonym)|uniprotkb:Paga(gene name synonym)|uniprotkb:Tdpx2(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642661|imex:IM-8314-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001264160.1|refseq:NP_031790.2|ensembl:ENSMUSG00000006134(gene)|ensembl:ENSMUST00000006293(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007389"(pattern specification process)|go:"GO:0007416"(synapse assembly)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045202"(synapse)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071774"(response to fibroblast growth factor)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P47941|reactome:R-MMU-170968|reactome:R-MMU-186763|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-9027284|go:"GO:0035690"|reactome:R-MMU-912631	refseq:NP_035164.1|ensembl:ENSMUST00000135573(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000791"(euchromatin)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0020037"(heme binding)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:P35700|reactome:R-MMU-3299685|reactome:R-MMU-5628897|ensembl:ENSMUST00000106470(transcript)|ensembl:ENSMUSG00000028691(gene)	psi-mi:"MI:0469"(intact)	-	-	delivery method:P47941 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:pLiTTJ+yoeda+z2DvpqltHFJ9M010090	rogid:xOppWev1GtpILoJ1rY+tSPoymVU10090	intact-crc:4B7E3B06D3A1963C|rigid:bDWm1gvBOeLic1C+dwIZ6Hjw/ZM	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P47941	uniprotkb:Q9ESJ4	intact:EBI-2642655|uniprotkb:Q8BGC5|uniprotkb:Q3TQ18|ensembl:ENSMUSP00000006293	intact:EBI-774750|uniprotkb:Q68G72|uniprotkb:Q3UYF3|ensembl:ENSMUSP00000035218	psi-mi:crkl_mouse(display_long)|uniprotkb:Crkol(gene name synonym)|uniprotkb:Crkl(gene name)|psi-mi:Crkl(display_short)	psi-mi:spn90_mouse(display_long)|uniprotkb:SH3 adapter protein SPIN90(gene name synonym)|uniprotkb:90 kDa SH3 protein interacting with Nck(gene name synonym)|uniprotkb:54 kDa VacA-interacting protein(gene name synonym)|uniprotkb:90 kDa N-WASP-interacting protein(gene name synonym)|uniprotkb:Wiskott-Aldrich syndrome protein-binding protein(gene name synonym)|uniprotkb:WASP-interacting SH3-domain protein(gene name synonym)|uniprotkb:Nckipsd(gene name)|psi-mi:Nckipsd(display_short)|uniprotkb:Spin90(gene name synonym)|uniprotkb:Wasbp(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642661|imex:IM-8314-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001264160.1|refseq:NP_031790.2|ensembl:ENSMUSG00000006134(gene)|ensembl:ENSMUST00000006293(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007389"(pattern specification process)|go:"GO:0007416"(synapse assembly)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045202"(synapse)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071774"(response to fibroblast growth factor)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P47941|reactome:R-MMU-170968|reactome:R-MMU-186763|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-9027284|go:"GO:0035690"|reactome:R-MMU-912631	refseq:NP_109654.2|ensembl:ENSMUSG00000032598(gene)|ensembl:ENSMUST00000035218(transcript)|go:"GO:0006897"(endocytosis)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0017022"(myosin binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0071933"(Arp2/3 complex binding)|interpro:IPR001452(Src homology-3)|interpro:IPR018556|interpro:IPR030125|interpro:IPR035514|interpro:IPR036028|mint:Q9ESJ4|reactome:R-MMU-2029482|reactome:R-MMU-5663213	psi-mi:"MI:0469"(intact)	-	-	delivery method:P47941 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:pLiTTJ+yoeda+z2DvpqltHFJ9M010090	rogid:6peQHO4g2hMvjA+Tg34MwBUyYeQ10090	intact-crc:4B7E3B06D3A1963C|rigid:bDWm1gvBOeLic1C+dwIZ6Hjw/ZM	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P47941	uniprotkb:P63038	intact:EBI-2642655|uniprotkb:Q8BGC5|uniprotkb:Q3TQ18|ensembl:ENSMUSP00000006293	intact:EBI-299343|ensembl:ENSMUSP00000027123|uniprotkb:P19226|uniprotkb:P19227|uniprotkb:P97602|uniprotkb:Q3KQP2|uniprotkb:Q3UIP0|uniprotkb:Q8C2C7|uniprotkb:Q8VEF4	psi-mi:crkl_mouse(display_long)|uniprotkb:Crkol(gene name synonym)|uniprotkb:Crkl(gene name)|psi-mi:Crkl(display_short)	psi-mi:ch60_mouse(display_long)|uniprotkb:Hspd1(gene name)|psi-mi:Hspd1(display_short)|uniprotkb:Hsp60(gene name synonym)|uniprotkb:Heat shock protein 60(gene name synonym)|uniprotkb:60 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 60(gene name synonym)|uniprotkb:Mitochondrial matrix protein P1(gene name synonym)|uniprotkb:HSP-65(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642661|imex:IM-8314-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001264160.1|refseq:NP_031790.2|ensembl:ENSMUSG00000006134(gene)|ensembl:ENSMUST00000006293(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007389"(pattern specification process)|go:"GO:0007416"(synapse assembly)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045202"(synapse)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071774"(response to fibroblast growth factor)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P47941|reactome:R-MMU-170968|reactome:R-MMU-186763|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-9027284|go:"GO:0035690"|reactome:R-MMU-912631	ensembl:ENSMUSG00000025980(gene)|ensembl:ENSMUST00000027123(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002931"(response to ischemia)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006457"(protein folding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030135"(coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042026"(protein refolding)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0045121"(membrane raft)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0048291"(isotype switching to IgG isotypes)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0097225"(sperm midpiece)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR001844(Chaperonin Cpn60)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR018370|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P63038|reactome:R-MMU-1268020|refseq:XP_006495769.1|refseq:NP_034607.3|dip:DIP-31396N	psi-mi:"MI:0469"(intact)	-	-	delivery method:P47941 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:pLiTTJ+yoeda+z2DvpqltHFJ9M010090	rogid:WD1fQLh4I0ovpakE8KtM1R0XpL410090	intact-crc:4B7E3B06D3A1963C|rigid:bDWm1gvBOeLic1C+dwIZ6Hjw/ZM	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P97465	uniprotkb:P00519	intact:EBI-914917|uniprotkb:Q9R213|ensembl:ENSMUSP00000087079	intact:EBI-375543|uniprotkb:Q13869|uniprotkb:Q13870|uniprotkb:Q16133|uniprotkb:Q45F09|ensembl:ENSP00000323315|uniprotkb:A3KFJ3|uniprotkb:Q17R61|intact:EBI-1550796	psi-mi:dok1_mouse(display_long)|uniprotkb:Downstream of tyrosine kinase 1(gene name synonym)|uniprotkb:"p62(dok)"(gene name synonym)|uniprotkb:Dok1(gene name)|psi-mi:Dok1(display_short)|uniprotkb:Dok(gene name synonym)	psi-mi:abl1_human(display_long)|uniprotkb:Abelson tyrosine-protein kinase 1(gene name synonym)|uniprotkb:ABL1(gene name)|psi-mi:ABL1(display_short)|uniprotkb:ABL(gene name synonym)|uniprotkb:JTK7(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 1(gene name synonym)|uniprotkb:Proto-oncogene c-Abl(gene name synonym)|uniprotkb:p150(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642676|imex:IM-8314-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034200.4|refseq:NP_001278728.1|ensembl:ENSMUSG00000068335(gene)|ensembl:ENSMUST00000089651(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0043409"(negative regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:P97465|rcsb pdb:1P5T|rcsb pdb:1UEF|reactome:R-MMU-8849469|reactome:R-MMU-8853659	refseq:NP_005148.2|refseq:NP_009297.2|ensembl:ENSG00000097007(gene)|ensembl:ENST00000318560(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016301"(kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019905"(syntaxin binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030035"(microspike assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002333"(transitional one stage B cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004515"(nicotinate-nucleotide adenylyltransferase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0038191"(neuropilin binding)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048668"(collateral sprouting)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071103"(DNA conformation change)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072359"(circulatory system development)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090135"(actin filament branching)|go:"GO:0098794"(postsynapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900275"(negative regulation of phospholipase C activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1903053"(regulation of extracellular matrix organization)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015015(F-actin binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR033221|interpro:IPR035837|interpro:IPR036028|interpro:IPR036860|mint:P00519|rcsb pdb:1AB2|rcsb pdb:1ABL|rcsb pdb:2HIW|rcsb pdb:2HYY|rcsb pdb:2HZ0|rcsb pdb:2HZ4|rcsb pdb:2HZI|rcsb pdb:2O88|rcsb pdb:2V7A|rcsb pdb:3CS9|rcsb pdb:3EG0|rcsb pdb:3EG1|rcsb pdb:3EG2|rcsb pdb:3EG3|rcsb pdb:3EGU|rcsb pdb:3K2M|rcsb pdb:3PYY|rcsb pdb:3QRI|rcsb pdb:3QRJ|rcsb pdb:3QRK|rcsb pdb:3T04|rcsb pdb:3UE4|rcsb pdb:3UYO|rcsb pdb:4J9B|rcsb pdb:4J9C|rcsb pdb:4J9D|rcsb pdb:1AWO|rcsb pdb:1BBZ|rcsb pdb:1JU5|rcsb pdb:1OPL|rcsb pdb:1ZZP|rcsb pdb:2ABL|rcsb pdb:2E2B|rcsb pdb:2F4J|rcsb pdb:2FO0|rcsb pdb:4J9E|rcsb pdb:2G1T|rcsb pdb:4J9F|rcsb pdb:2G2F|rcsb pdb:2G2H|rcsb pdb:4J9G|rcsb pdb:2G2I|rcsb pdb:4J9H|rcsb pdb:2GQG|rcsb pdb:4J9I|rcsb pdb:4JJB|rcsb pdb:4JJC|rcsb pdb:4JJD|rcsb pdb:4TWP|rcsb pdb:4WA9|rcsb pdb:4XEY|rcsb pdb:4YC8|rcsb pdb:4ZOG|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5HU9|rcsb pdb:5MO4|rcsb pdb:5NP2|rcsb pdb:5OAZ|rcsb pdb:6AMV|rcsb pdb:6AMW|rcsb pdb:6BL8|rcsb pdb:6NPE|rcsb pdb:6NPU|rcsb pdb:6NPV|rcsb pdb:6XR6|rcsb pdb:6XR7|rcsb pdb:6XRG|rcsb pdb:7CC2|rcsb pdb:7DT2|reactome:R-HSA-2029482|reactome:R-HSA-428890|reactome:R-HSA-525793|reactome:R-HSA-5663213|reactome:R-HSA-5685938|reactome:R-HSA-5693565|reactome:R-HSA-69231|reactome:R-HSA-8939236|reactome:R-HSA-8940973|reactome:R-HSA-9664422|reactome:R-HSA-983231|dip:DIP-1042N	psi-mi:"MI:0469"(intact)	-	-	delivery method:P97465 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:7GKYnqXCQie+Z26maTxfYF4ShNE10090	rogid:t7dT+fWrrK2QaWF4U0HQaVgHKUc9606	intact-crc:4347501A45580D02|rigid:dAt3xTGeS9NCCNfmfucU5s05gzI	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P97465	uniprotkb:Q9ES52	intact:EBI-914917|uniprotkb:Q9R213|ensembl:ENSMUSP00000087079	intact:EBI-300210|ensembl:ENSMUSP00000127941|uniprotkb:Q3UPF9|uniprotkb:Q4U212|uniprotkb:Q61034|uniprotkb:Q61173|uniprotkb:Q61181|uniprotkb:Q9JKR7|uniprotkb:Q9JLF9|uniprotkb:Q9JLG0|uniprotkb:Q9QVN8|uniprotkb:Q9WUC2	psi-mi:dok1_mouse(display_long)|uniprotkb:Downstream of tyrosine kinase 1(gene name synonym)|uniprotkb:"p62(dok)"(gene name synonym)|uniprotkb:Dok1(gene name)|psi-mi:Dok1(display_short)|uniprotkb:Dok(gene name synonym)	psi-mi:ship1_mouse(display_long)|uniprotkb:Inpp5d(gene name)|psi-mi:Inpp5d(display_short)|uniprotkb:Ship(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase of 145 kDa(gene name synonym)|uniprotkb:p150Ship(gene name synonym)|uniprotkb:7a33(gene name synonym)|uniprotkb:Ship1(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase D(gene name synonym)|uniprotkb:Phosphatidylinositol-4,5-bisphosphate 5-phosphatase(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642676|imex:IM-8314-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034200.4|refseq:NP_001278728.1|ensembl:ENSMUSG00000068335(gene)|ensembl:ENSMUST00000089651(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0043409"(negative regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:P97465|rcsb pdb:1P5T|rcsb pdb:1UEF|reactome:R-MMU-8849469|reactome:R-MMU-8853659	ensembl:ENSMUSG00000026288(gene)|ensembl:ENSMUST00000169754(transcript)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030487"(inositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045659"(negative regulation of neutrophil differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR036860|go:"GO:0050777"(negative regulation of immune response)|rcsb pdb:6DLG|reactome:R-MMU-1660499|reactome:R-MMU-1855204|reactome:R-MMU-202424|reactome:R-MMU-210990|reactome:R-MMU-912526|refseq:NP_001103662.1|refseq:NP_001103663.1|refseq:NP_034696.2	psi-mi:"MI:0469"(intact)	-	-	delivery method:P97465 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:7GKYnqXCQie+Z26maTxfYF4ShNE10090	rogid:ipXHzUIAHLTMnjElS7ngcCqFuak10090	intact-crc:4347501A45580D02|rigid:dAt3xTGeS9NCCNfmfucU5s05gzI	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P97465	uniprotkb:O55033	intact:EBI-914917|uniprotkb:Q9R213|ensembl:ENSMUSP00000087079	intact:EBI-2642725|ensembl:ENSMUSP00000083611	psi-mi:dok1_mouse(display_long)|uniprotkb:Downstream of tyrosine kinase 1(gene name synonym)|uniprotkb:"p62(dok)"(gene name synonym)|uniprotkb:Dok1(gene name)|psi-mi:Dok1(display_short)|uniprotkb:Dok(gene name synonym)	psi-mi:nck2_mouse(display_long)|uniprotkb:Nck2(gene name)|psi-mi:Nck2(display_short)|uniprotkb:Grb4(gene name synonym)|uniprotkb:Growth factor receptor-bound protein 4(gene name synonym)|uniprotkb:NCK adaptor protein 2(gene name synonym)|uniprotkb:SH2/SH3 adaptor protein NCK-beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642676|imex:IM-8314-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034200.4|refseq:NP_001278728.1|ensembl:ENSMUSG00000068335(gene)|ensembl:ENSMUST00000089651(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0043409"(negative regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:P97465|rcsb pdb:1P5T|rcsb pdb:1UEF|reactome:R-MMU-8849469|reactome:R-MMU-8853659	refseq:NP_035009.3|ensembl:ENSMUSG00000066877(gene)|ensembl:ENSMUST00000086421(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0007015"(actin filament organization)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0060996"(dendritic spine development)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028524|interpro:IPR035559|interpro:IPR035560|interpro:IPR035561|interpro:IPR035883|interpro:IPR036028|interpro:IPR036860|mint:O55033|reactome:R-MMU-186763|reactome:R-MMU-373753|reactome:R-MMU-3928664|reactome:R-MMU-4420097|reactome:R-MMU-9013420|reactome:R-MMU-9013424	psi-mi:"MI:0469"(intact)	-	-	delivery method:P97465 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:7GKYnqXCQie+Z26maTxfYF4ShNE10090	rogid:mFoknzNaD3XbNFCp57d5BUqEtAo10090	intact-crc:4347501A45580D02|rigid:dAt3xTGeS9NCCNfmfucU5s05gzI	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P97465	uniprotkb:P24604	intact:EBI-914917|uniprotkb:Q9R213|ensembl:ENSMUSP00000087079	intact:EBI-2642705|uniprotkb:Q9WVN1|uniprotkb:Q9R1M9|uniprotkb:Q9WVN2|uniprotkb:Q9WVN0|uniprotkb:Q9WVN3	psi-mi:dok1_mouse(display_long)|uniprotkb:Downstream of tyrosine kinase 1(gene name synonym)|uniprotkb:"p62(dok)"(gene name synonym)|uniprotkb:Dok1(gene name)|psi-mi:Dok1(display_short)|uniprotkb:Dok(gene name synonym)	psi-mi:tec_mouse(display_long)|uniprotkb:Tec(gene name)|psi-mi:Tec(display_short)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642676|imex:IM-8314-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034200.4|refseq:NP_001278728.1|ensembl:ENSMUSG00000068335(gene)|ensembl:ENSMUST00000089651(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0043409"(negative regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:P97465|rcsb pdb:1P5T|rcsb pdb:1UEF|reactome:R-MMU-8849469|reactome:R-MMU-8853659	refseq:XP_011239020.1|refseq:XP_011239021.1|refseq:NP_001106931.1|refseq:NP_001106932.1|refseq:NP_001106935.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR020635|interpro:IPR001562(Tec/Btk)|mint:P24604|refseq:XP_006503908.1|refseq:XP_006503909.1|go:"GO:0008289"(lipid binding)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042246"(tissue regeneration)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|rcsb pdb:1GL5|reactome:R-MMU-1433557|reactome:R-MMU-2871809|reactome:R-MMU-512988|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|interpro:IPR035572|interpro:IPR036028|interpro:IPR036860	psi-mi:"MI:0469"(intact)	-	-	delivery method:P97465 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:7GKYnqXCQie+Z26maTxfYF4ShNE10090	rogid:CNlxt84miYDwiolJx6Qw8fwO2j810090	intact-crc:4347501A45580D02|rigid:dAt3xTGeS9NCCNfmfucU5s05gzI	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P97465	uniprotkb:P41241	intact:EBI-914917|uniprotkb:Q9R213|ensembl:ENSMUSP00000087079	intact:EBI-2553183|uniprotkb:Q80WU4|uniprotkb:Q8VCW1|ensembl:ENSMUSP00000034863|ensembl:ENSMUSP00000150590|ensembl:ENSMUSP00000150984|uniprotkb:Q03143	psi-mi:dok1_mouse(display_long)|uniprotkb:Downstream of tyrosine kinase 1(gene name synonym)|uniprotkb:"p62(dok)"(gene name synonym)|uniprotkb:Dok1(gene name)|psi-mi:Dok1(display_short)|uniprotkb:Dok(gene name synonym)	psi-mi:csk_mouse(display_long)|uniprotkb:Csk(gene name)|psi-mi:Csk(display_short)|uniprotkb:C-Src kinase(gene name synonym)|uniprotkb:Protein-tyrosine kinase MPK-2(gene name synonym)|uniprotkb:p50CSK(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642676|imex:IM-8314-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034200.4|refseq:NP_001278728.1|ensembl:ENSMUSG00000068335(gene)|ensembl:ENSMUST00000089651(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0043409"(negative regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:P97465|rcsb pdb:1P5T|rcsb pdb:1UEF|reactome:R-MMU-8849469|reactome:R-MMU-8853659	refseq:NP_001291690.1|go:"GO:0016740"(transferase activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005911"(cell-cell junction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048709"(oligodendrocyte differentiation)|ensembl:ENSMUSG00000032312(gene)|ensembl:ENSMUST00000034863(transcript)|ensembl:ENSMUST00000215396(transcript)|ensembl:ENSMUST00000217314(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|go:"GO:0050765"(negative regulation of phagocytosis)|interpro:IPR035027|interpro:IPR036028|interpro:IPR036860|rcsb pdb:1JEG|reactome:R-MMU-180292|reactome:R-MMU-202427|reactome:R-MMU-354192|reactome:R-MMU-389948|reactome:R-MMU-5674135|reactome:R-MMU-9013407|reactome:R-MMU-9706369|refseq:NP_031809.2|refseq:XP_006510864.1|refseq:XP_006510865.1	psi-mi:"MI:0469"(intact)	-	-	delivery method:P97465 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:7GKYnqXCQie+Z26maTxfYF4ShNE10090	rogid:2unY4cD7qXpvYgIJ59ajuZ/FSiQ10090	intact-crc:4347501A45580D02|rigid:dAt3xTGeS9NCCNfmfucU5s05gzI	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P97465	uniprotkb:Q61753	intact:EBI-914917|uniprotkb:Q9R213|ensembl:ENSMUSP00000087079	intact:EBI-1633989|uniprotkb:Q3TEE5|uniprotkb:Q75SV9|uniprotkb:Q8C603|ensembl:ENSMUSP00000064755	psi-mi:dok1_mouse(display_long)|uniprotkb:Downstream of tyrosine kinase 1(gene name synonym)|uniprotkb:"p62(dok)"(gene name synonym)|uniprotkb:Dok1(gene name)|psi-mi:Dok1(display_short)|uniprotkb:Dok(gene name synonym)	psi-mi:sera_mouse(display_long)|uniprotkb:Phgdh(gene name)|psi-mi:Phgdh(display_short)|uniprotkb:A10(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642676|imex:IM-8314-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034200.4|refseq:NP_001278728.1|ensembl:ENSMUSG00000068335(gene)|ensembl:ENSMUST00000089651(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0043409"(negative regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:P97465|rcsb pdb:1P5T|rcsb pdb:1UEF|reactome:R-MMU-8849469|reactome:R-MMU-8853659	refseq:NP_058662.2|ensembl:ENSMUSG00000053398(gene)|ensembl:ENSMUST00000065793(transcript)|go:"GO:0004617"(phosphoglycerate dehydrogenase activity)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006563"(L-serine metabolic process)|go:"GO:0006564"(L-serine biosynthetic process)|go:"GO:0006566"(threonine metabolic process)|go:"GO:0009448"(gamma-aminobutyric acid metabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0021510"(spinal cord development)|go:"GO:0021782"(glial cell development)|go:"GO:0021915"(neural tube development)|go:"GO:0022008"(neurogenesis)|go:"GO:0031175"(neuron projection development)|go:"GO:0043209"(myelin sheath)|go:"GO:0051287"(NAD binding)|go:"GO:0070314"(G1 to G0 transition)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR006236(D-3-phosphoglycerate dehydrogenase)|interpro:IPR029009|interpro:IPR029752|interpro:IPR029753|interpro:IPR036291|mint:Q61753|reactome:R-MMU-977347	psi-mi:"MI:0469"(intact)	-	-	delivery method:P97465 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:7GKYnqXCQie+Z26maTxfYF4ShNE10090	rogid:66i2iIx5qSIN6BkqSPF14+UqDIA10090	intact-crc:4347501A45580D02|rigid:dAt3xTGeS9NCCNfmfucU5s05gzI	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P97465	uniprotkb:Q99M51	intact:EBI-914917|uniprotkb:Q9R213|ensembl:ENSMUSP00000087079	intact:EBI-642202|uniprotkb:O55032|uniprotkb:Q9Z279|intact:EBI-2642686|intact:EBI-643937|ensembl:ENSMUSP00000112221	psi-mi:dok1_mouse(display_long)|uniprotkb:Downstream of tyrosine kinase 1(gene name synonym)|uniprotkb:"p62(dok)"(gene name synonym)|uniprotkb:Dok1(gene name)|psi-mi:Dok1(display_short)|uniprotkb:Dok(gene name synonym)	psi-mi:nck1_mouse(display_long)|uniprotkb:Nck1(gene name)|psi-mi:Nck1(display_short)|uniprotkb:NCK adaptor protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642676|imex:IM-8314-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034200.4|refseq:NP_001278728.1|ensembl:ENSMUSG00000068335(gene)|ensembl:ENSMUST00000089651(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0043409"(negative regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:P97465|rcsb pdb:1P5T|rcsb pdb:1UEF|reactome:R-MMU-8849469|reactome:R-MMU-8853659	refseq:NP_035008.2|refseq:XP_006510903.1|ensembl:ENSMUSG00000032475(gene)|ensembl:ENSMUST00000116522(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-373753|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-983695|dip:DIP-37524N	psi-mi:"MI:0469"(intact)	-	-	delivery method:P97465 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:7GKYnqXCQie+Z26maTxfYF4ShNE10090	rogid:uq7YGxP9zh6bhhrOJdJa9D+3O2g10090	intact-crc:4347501A45580D02|rigid:dAt3xTGeS9NCCNfmfucU5s05gzI	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P97465	uniprotkb:Q91YX7	intact:EBI-914917|uniprotkb:Q9R213|ensembl:ENSMUSP00000087079	intact:EBI-1700	psi-mi:dok1_mouse(display_long)|uniprotkb:Downstream of tyrosine kinase 1(gene name synonym)|uniprotkb:"p62(dok)"(gene name synonym)|uniprotkb:Dok1(gene name)|psi-mi:Dok1(display_short)|uniprotkb:Dok(gene name synonym)	psi-mi:q91yx7_mouse(display_long)|uniprotkb:Rasa1(gene name)|psi-mi:Rasa1(display_short)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642676|imex:IM-8314-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034200.4|refseq:NP_001278728.1|ensembl:ENSMUSG00000068335(gene)|ensembl:ENSMUST00000089651(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0043409"(negative regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:P97465|rcsb pdb:1P5T|rcsb pdb:1UEF|reactome:R-MMU-8849469|reactome:R-MMU-8853659	interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR000980(SH2 motif)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR023152|interpro:IPR001452(Src homology-3)|interpro:IPR028554|interpro:IPR035652|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q91YX7|interpro:IPR039360|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051020"(GTPase binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1990782"(protein tyrosine kinase binding)	psi-mi:"MI:0469"(intact)	-	-	delivery method:P97465 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:7GKYnqXCQie+Z26maTxfYF4ShNE10090	rogid:D4nckFkhCy4t+TRC4dDzHvDVwrQ10090	intact-crc:4347501A45580D02|rigid:dAt3xTGeS9NCCNfmfucU5s05gzI	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P97465	uniprotkb:P11274	intact:EBI-914917|uniprotkb:Q9R213|ensembl:ENSMUSP00000087079	intact:EBI-712838|intact:EBI-28971369|ensembl:ENSP00000303507|uniprotkb:P78501|uniprotkb:Q12842|uniprotkb:Q4LE80|uniprotkb:Q6NZI3	psi-mi:dok1_mouse(display_long)|uniprotkb:Downstream of tyrosine kinase 1(gene name synonym)|uniprotkb:"p62(dok)"(gene name synonym)|uniprotkb:Dok1(gene name)|psi-mi:Dok1(display_short)|uniprotkb:Dok(gene name synonym)	psi-mi:bcr_human(display_long)|uniprotkb:Renal carcinoma antigen NY-REN-26(gene name synonym)|uniprotkb:BCR(gene name)|psi-mi:BCR(display_short)|uniprotkb:BCR1(gene name synonym)|uniprotkb:D22S11(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642676|imex:IM-8314-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034200.4|refseq:NP_001278728.1|ensembl:ENSMUSG00000068335(gene)|ensembl:ENSMUST00000089651(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0043409"(negative regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:P97465|rcsb pdb:1P5T|rcsb pdb:1UEF|reactome:R-MMU-8849469|reactome:R-MMU-8853659	ensembl:ENSG00000186716(gene)|ensembl:ENST00000305877(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030424"(axon)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0043197"(dendritic spine)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000198(RhoGAP)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR015123(Bcr-Abl oncoprotein oligomerisation)|interpro:IPR035892|interpro:IPR035899|interpro:IPR036481|interpro:IPR037769|rcsb pdb:1K1F|rcsb pdb:2AIN|rcsb pdb:5N6R|rcsb pdb:5N7E|rcsb pdb:5OC7|reactome:R-HSA-1839117|reactome:R-HSA-5655302|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|mint:P11274|ensembl:ENSP00000303507|ensembl:ENST00000359540|ensembl:ENSP00000352535|refseq:NP_004318.3|refseq:NP_067585.2	psi-mi:"MI:0469"(intact)	-	-	delivery method:P97465 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:7GKYnqXCQie+Z26maTxfYF4ShNE10090	rogid:U2+lPQ5c2dVW2MPLvknA0Bbg4fA9606	intact-crc:4347501A45580D02|rigid:dAt3xTGeS9NCCNfmfucU5s05gzI	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P97465	uniprotkb:Q60631	intact:EBI-914917|uniprotkb:Q9R213|ensembl:ENSMUSP00000087079	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:dok1_mouse(display_long)|uniprotkb:Downstream of tyrosine kinase 1(gene name synonym)|uniprotkb:"p62(dok)"(gene name synonym)|uniprotkb:Dok1(gene name)|psi-mi:Dok1(display_short)|uniprotkb:Dok(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642676|imex:IM-8314-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034200.4|refseq:NP_001278728.1|ensembl:ENSMUSG00000068335(gene)|ensembl:ENSMUST00000089651(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0043409"(negative regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:P97465|rcsb pdb:1P5T|rcsb pdb:1UEF|reactome:R-MMU-8849469|reactome:R-MMU-8853659	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	psi-mi:"MI:0469"(intact)	-	-	delivery method:P97465 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:7GKYnqXCQie+Z26maTxfYF4ShNE10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:4347501A45580D02|rigid:dAt3xTGeS9NCCNfmfucU5s05gzI	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70469	uniprotkb:P97465	intact:EBI-2642743|uniprotkb:Q99KL1|uniprotkb:O70272|ensembl:ENSMUSP00000022698	intact:EBI-914917|uniprotkb:Q9R213|ensembl:ENSMUSP00000087079	psi-mi:dok2_mouse(display_long)|uniprotkb:Frip(gene name synonym)|uniprotkb:Dok-related protein(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 2(gene name synonym)|uniprotkb:IL-four receptor-interacting protein(gene name synonym)|uniprotkb:"p56(dok-2)"(gene name synonym)|uniprotkb:Dok2(gene name)|psi-mi:Dok2(display_short)	psi-mi:dok1_mouse(display_long)|uniprotkb:Downstream of tyrosine kinase 1(gene name synonym)|uniprotkb:"p62(dok)"(gene name synonym)|uniprotkb:Dok1(gene name)|psi-mi:Dok1(display_short)|uniprotkb:Dok(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642749|imex:IM-8314-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034201.1|ensembl:ENSMUSG00000022102(gene)|ensembl:ENSMUST00000022698(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0043409"(negative regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:O70469|reactome:R-MMU-210993|reactome:R-MMU-8853659	refseq:NP_034200.4|refseq:NP_001278728.1|ensembl:ENSMUSG00000068335(gene)|ensembl:ENSMUST00000089651(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0043409"(negative regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:P97465|rcsb pdb:1P5T|rcsb pdb:1UEF|reactome:R-MMU-8849469|reactome:R-MMU-8853659	psi-mi:"MI:0469"(intact)	-	-	delivery method:O70469 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:gmWujnislEDULA6fvk5kHsJMrts10090	rogid:7GKYnqXCQie+Z26maTxfYF4ShNE10090	intact-crc:D306B1905199B2B8|rigid:nhmPatmc69jlYM+nOsF0mnzeNxw	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70469	uniprotkb:O55033	intact:EBI-2642743|uniprotkb:Q99KL1|uniprotkb:O70272|ensembl:ENSMUSP00000022698	intact:EBI-2642725|ensembl:ENSMUSP00000083611	psi-mi:dok2_mouse(display_long)|uniprotkb:Frip(gene name synonym)|uniprotkb:Dok-related protein(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 2(gene name synonym)|uniprotkb:IL-four receptor-interacting protein(gene name synonym)|uniprotkb:"p56(dok-2)"(gene name synonym)|uniprotkb:Dok2(gene name)|psi-mi:Dok2(display_short)	psi-mi:nck2_mouse(display_long)|uniprotkb:Nck2(gene name)|psi-mi:Nck2(display_short)|uniprotkb:Grb4(gene name synonym)|uniprotkb:Growth factor receptor-bound protein 4(gene name synonym)|uniprotkb:NCK adaptor protein 2(gene name synonym)|uniprotkb:SH2/SH3 adaptor protein NCK-beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642749|imex:IM-8314-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034201.1|ensembl:ENSMUSG00000022102(gene)|ensembl:ENSMUST00000022698(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0043409"(negative regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:O70469|reactome:R-MMU-210993|reactome:R-MMU-8853659	refseq:NP_035009.3|ensembl:ENSMUSG00000066877(gene)|ensembl:ENSMUST00000086421(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0007015"(actin filament organization)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0060996"(dendritic spine development)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028524|interpro:IPR035559|interpro:IPR035560|interpro:IPR035561|interpro:IPR035883|interpro:IPR036028|interpro:IPR036860|mint:O55033|reactome:R-MMU-186763|reactome:R-MMU-373753|reactome:R-MMU-3928664|reactome:R-MMU-4420097|reactome:R-MMU-9013420|reactome:R-MMU-9013424	psi-mi:"MI:0469"(intact)	-	-	delivery method:O70469 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:gmWujnislEDULA6fvk5kHsJMrts10090	rogid:mFoknzNaD3XbNFCp57d5BUqEtAo10090	intact-crc:D306B1905199B2B8|rigid:nhmPatmc69jlYM+nOsF0mnzeNxw	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70469	uniprotkb:Q99M51	intact:EBI-2642743|uniprotkb:Q99KL1|uniprotkb:O70272|ensembl:ENSMUSP00000022698	intact:EBI-642202|uniprotkb:O55032|uniprotkb:Q9Z279|intact:EBI-2642686|intact:EBI-643937|ensembl:ENSMUSP00000112221	psi-mi:dok2_mouse(display_long)|uniprotkb:Frip(gene name synonym)|uniprotkb:Dok-related protein(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 2(gene name synonym)|uniprotkb:IL-four receptor-interacting protein(gene name synonym)|uniprotkb:"p56(dok-2)"(gene name synonym)|uniprotkb:Dok2(gene name)|psi-mi:Dok2(display_short)	psi-mi:nck1_mouse(display_long)|uniprotkb:Nck1(gene name)|psi-mi:Nck1(display_short)|uniprotkb:NCK adaptor protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642749|imex:IM-8314-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034201.1|ensembl:ENSMUSG00000022102(gene)|ensembl:ENSMUST00000022698(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0043409"(negative regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:O70469|reactome:R-MMU-210993|reactome:R-MMU-8853659	refseq:NP_035008.2|refseq:XP_006510903.1|ensembl:ENSMUSG00000032475(gene)|ensembl:ENSMUST00000116522(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-373753|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-983695|dip:DIP-37524N	psi-mi:"MI:0469"(intact)	-	-	delivery method:O70469 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:gmWujnislEDULA6fvk5kHsJMrts10090	rogid:uq7YGxP9zh6bhhrOJdJa9D+3O2g10090	intact-crc:D306B1905199B2B8|rigid:nhmPatmc69jlYM+nOsF0mnzeNxw	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70469	uniprotkb:P11274	intact:EBI-2642743|uniprotkb:Q99KL1|uniprotkb:O70272|ensembl:ENSMUSP00000022698	intact:EBI-712838|intact:EBI-28971369|ensembl:ENSP00000303507|uniprotkb:P78501|uniprotkb:Q12842|uniprotkb:Q4LE80|uniprotkb:Q6NZI3	psi-mi:dok2_mouse(display_long)|uniprotkb:Frip(gene name synonym)|uniprotkb:Dok-related protein(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 2(gene name synonym)|uniprotkb:IL-four receptor-interacting protein(gene name synonym)|uniprotkb:"p56(dok-2)"(gene name synonym)|uniprotkb:Dok2(gene name)|psi-mi:Dok2(display_short)	psi-mi:bcr_human(display_long)|uniprotkb:Renal carcinoma antigen NY-REN-26(gene name synonym)|uniprotkb:BCR(gene name)|psi-mi:BCR(display_short)|uniprotkb:BCR1(gene name synonym)|uniprotkb:D22S11(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642749|imex:IM-8314-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034201.1|ensembl:ENSMUSG00000022102(gene)|ensembl:ENSMUST00000022698(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0043409"(negative regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:O70469|reactome:R-MMU-210993|reactome:R-MMU-8853659	ensembl:ENSG00000186716(gene)|ensembl:ENST00000305877(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030424"(axon)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0043197"(dendritic spine)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000198(RhoGAP)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR015123(Bcr-Abl oncoprotein oligomerisation)|interpro:IPR035892|interpro:IPR035899|interpro:IPR036481|interpro:IPR037769|rcsb pdb:1K1F|rcsb pdb:2AIN|rcsb pdb:5N6R|rcsb pdb:5N7E|rcsb pdb:5OC7|reactome:R-HSA-1839117|reactome:R-HSA-5655302|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|mint:P11274|ensembl:ENSP00000303507|ensembl:ENST00000359540|ensembl:ENSP00000352535|refseq:NP_004318.3|refseq:NP_067585.2	psi-mi:"MI:0469"(intact)	-	-	delivery method:O70469 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:gmWujnislEDULA6fvk5kHsJMrts10090	rogid:U2+lPQ5c2dVW2MPLvknA0Bbg4fA9606	intact-crc:D306B1905199B2B8|rigid:nhmPatmc69jlYM+nOsF0mnzeNxw	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70469	uniprotkb:Q9ES52	intact:EBI-2642743|uniprotkb:Q99KL1|uniprotkb:O70272|ensembl:ENSMUSP00000022698	intact:EBI-300210|ensembl:ENSMUSP00000127941|uniprotkb:Q3UPF9|uniprotkb:Q4U212|uniprotkb:Q61034|uniprotkb:Q61173|uniprotkb:Q61181|uniprotkb:Q9JKR7|uniprotkb:Q9JLF9|uniprotkb:Q9JLG0|uniprotkb:Q9QVN8|uniprotkb:Q9WUC2	psi-mi:dok2_mouse(display_long)|uniprotkb:Frip(gene name synonym)|uniprotkb:Dok-related protein(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 2(gene name synonym)|uniprotkb:IL-four receptor-interacting protein(gene name synonym)|uniprotkb:"p56(dok-2)"(gene name synonym)|uniprotkb:Dok2(gene name)|psi-mi:Dok2(display_short)	psi-mi:ship1_mouse(display_long)|uniprotkb:Inpp5d(gene name)|psi-mi:Inpp5d(display_short)|uniprotkb:Ship(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase of 145 kDa(gene name synonym)|uniprotkb:p150Ship(gene name synonym)|uniprotkb:7a33(gene name synonym)|uniprotkb:Ship1(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase D(gene name synonym)|uniprotkb:Phosphatidylinositol-4,5-bisphosphate 5-phosphatase(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642749|imex:IM-8314-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034201.1|ensembl:ENSMUSG00000022102(gene)|ensembl:ENSMUST00000022698(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0043409"(negative regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:O70469|reactome:R-MMU-210993|reactome:R-MMU-8853659	ensembl:ENSMUSG00000026288(gene)|ensembl:ENSMUST00000169754(transcript)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030487"(inositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045659"(negative regulation of neutrophil differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR036860|go:"GO:0050777"(negative regulation of immune response)|rcsb pdb:6DLG|reactome:R-MMU-1660499|reactome:R-MMU-1855204|reactome:R-MMU-202424|reactome:R-MMU-210990|reactome:R-MMU-912526|refseq:NP_001103662.1|refseq:NP_001103663.1|refseq:NP_034696.2	psi-mi:"MI:0469"(intact)	-	-	delivery method:O70469 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:gmWujnislEDULA6fvk5kHsJMrts10090	rogid:ipXHzUIAHLTMnjElS7ngcCqFuak10090	intact-crc:D306B1905199B2B8|rigid:nhmPatmc69jlYM+nOsF0mnzeNxw	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70469	uniprotkb:Q91YX7	intact:EBI-2642743|uniprotkb:Q99KL1|uniprotkb:O70272|ensembl:ENSMUSP00000022698	intact:EBI-1700	psi-mi:dok2_mouse(display_long)|uniprotkb:Frip(gene name synonym)|uniprotkb:Dok-related protein(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 2(gene name synonym)|uniprotkb:IL-four receptor-interacting protein(gene name synonym)|uniprotkb:"p56(dok-2)"(gene name synonym)|uniprotkb:Dok2(gene name)|psi-mi:Dok2(display_short)	psi-mi:q91yx7_mouse(display_long)|uniprotkb:Rasa1(gene name)|psi-mi:Rasa1(display_short)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642749|imex:IM-8314-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034201.1|ensembl:ENSMUSG00000022102(gene)|ensembl:ENSMUST00000022698(transcript)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0043409"(negative regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:O70469|reactome:R-MMU-210993|reactome:R-MMU-8853659	interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR000980(SH2 motif)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR023152|interpro:IPR001452(Src homology-3)|interpro:IPR028554|interpro:IPR035652|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q91YX7|interpro:IPR039360|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051020"(GTPase binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1990782"(protein tyrosine kinase binding)	psi-mi:"MI:0469"(intact)	-	-	delivery method:O70469 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:gmWujnislEDULA6fvk5kHsJMrts10090	rogid:D4nckFkhCy4t+TRC4dDzHvDVwrQ10090	intact-crc:D306B1905199B2B8|rigid:nhmPatmc69jlYM+nOsF0mnzeNxw	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z1S8	uniprotkb:P35235	intact:EBI-641738|uniprotkb:Q9R1X3	intact:EBI-397236|uniprotkb:Q3TQ84|uniprotkb:Q64509|uniprotkb:Q6PCL5|ensembl:ENSMUSP00000098333	psi-mi:gab2_mouse(display_long)|uniprotkb:Growth factor receptor bound protein 2-associated protein 2(gene name synonym)|uniprotkb:GRB2-associated binder 2(gene name synonym)|uniprotkb:PH domain-containing adaptor molecule p97(gene name synonym)|uniprotkb:Gab2(gene name)|psi-mi:Gab2(display_short)	psi-mi:ptn11_mouse(display_long)|uniprotkb:Ptpn11(gene name)|psi-mi:Ptpn11(display_short)|uniprotkb:Protein-tyrosine phosphatase SYP(gene name synonym)|uniprotkb:SH-PTP2(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642779|imex:IM-8314-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-MMU-109704|reactome:R-MMU-1433557|reactome:R-MMU-2730905|reactome:R-MMU-8853659|reactome:R-MMU-912526|dip:DIP-41351N|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|reactome:R-MMU-9674555|reactome:R-MMU-1257604|reactome:R-MMU-6811558|reactome:R-MMU-9607240	refseq:NP_001103462.1|refseq:NP_035332.1|go:"GO:0048609"(multicellular organismal reproductive process)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0048806"(genitalia development)|go:"GO:0048839"(inner ear development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051463"(negative regulation of cortisol secretion)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060325"(face morphogenesis)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0061582"(intestinal epithelial cell migration)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P35235|rcsb pdb:1AYA|rcsb pdb:1AYB|rcsb pdb:1AYC|rcsb pdb:1AYD|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|reactome:R-MMU-1059683|reactome:R-MMU-109704|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|reactome:R-MMU-110056|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|reactome:R-MMU-112411|reactome:R-MMU-114604|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|reactome:R-MMU-1257604|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-210990|reactome:R-MMU-210993|reactome:R-MMU-388841|reactome:R-MMU-389513|reactome:R-MMU-389948|reactome:R-MMU-432142|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-8854691|reactome:R-MMU-8865999|reactome:R-MMU-8934593|reactome:R-MMU-909733|reactome:R-MMU-912694|reactome:R-MMU-936964|reactome:R-MMU-9674555|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654700|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-6811558|reactome:R-MMU-8853659|ensembl:ENSMUSG00000043733(gene)|ensembl:ENSMUST00000100770(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030220"(platelet formation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032528"(microvillus organization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035265"(organ growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|dip:DIP-29669N	psi-mi:"MI:0469"(intact)	-	-	delivery method:Q9Z1S8 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2020/01/07	rogid:DV50jtkpOksZpaqjllQRhmpYkvk10090	rogid:KL26Wt9vwG525fZ5SfvLc71Wsng10090	intact-crc:21B2904C9DA88411|rigid:L9ZERF3YZ+bhMjV9srq+aNycPCw	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z1S8	uniprotkb:B1AT92	intact:EBI-641738|uniprotkb:Q9R1X3	intact:EBI-2642808|ensembl:ENSMUSP00000102104	psi-mi:gab2_mouse(display_long)|uniprotkb:Growth factor receptor bound protein 2-associated protein 2(gene name synonym)|uniprotkb:GRB2-associated binder 2(gene name synonym)|uniprotkb:PH domain-containing adaptor molecule p97(gene name synonym)|uniprotkb:Gab2(gene name)|psi-mi:Gab2(display_short)	psi-mi:b1at92_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642779|imex:IM-8314-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-MMU-109704|reactome:R-MMU-1433557|reactome:R-MMU-2730905|reactome:R-MMU-8853659|reactome:R-MMU-912526|dip:DIP-41351N|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|reactome:R-MMU-9674555|reactome:R-MMU-1257604|reactome:R-MMU-6811558|reactome:R-MMU-9607240	ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000106495(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR036028|interpro:IPR036860	psi-mi:"MI:0469"(intact)	-	-	delivery method:Q9Z1S8 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2020/01/07	rogid:DV50jtkpOksZpaqjllQRhmpYkvk10090	rogid:LpgsrJMXp5G6BJf04DHoQQkvoHc10090	intact-crc:21B2904C9DA88411|rigid:L9ZERF3YZ+bhMjV9srq+aNycPCw	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z1S8	uniprotkb:Q9Z0N1	intact:EBI-641738|uniprotkb:Q9R1X3	intact:EBI-2642789|ensembl:ENSMUSP00000059395	psi-mi:gab2_mouse(display_long)|uniprotkb:Growth factor receptor bound protein 2-associated protein 2(gene name synonym)|uniprotkb:GRB2-associated binder 2(gene name synonym)|uniprotkb:PH domain-containing adaptor molecule p97(gene name synonym)|uniprotkb:Gab2(gene name)|psi-mi:Gab2(display_short)	psi-mi:if2g_mouse(display_long)|uniprotkb:Eif2s3x(gene name)|psi-mi:Eif2s3x(display_short)|uniprotkb:Eukaryotic translation initiation factor 2 subunit gamma, X-linked(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642779|imex:IM-8314-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-MMU-109704|reactome:R-MMU-1433557|reactome:R-MMU-2730905|reactome:R-MMU-8853659|reactome:R-MMU-912526|dip:DIP-41351N|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|reactome:R-MMU-9674555|reactome:R-MMU-1257604|reactome:R-MMU-6811558|reactome:R-MMU-9607240	refseq:NP_036140.1|ensembl:ENSMUSG00000035150(gene)|ensembl:ENSMUST00000050328(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0045903"(positive regulation of translational fidelity)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR015256(Initiation factor eIF2 gamma, C terminal)|interpro:IPR027417|interpro:IPR044127|interpro:IPR044128|mint:Q9Z0N1|reactome:R-MMU-156827|reactome:R-MMU-381042|reactome:R-MMU-382556|reactome:R-MMU-72649|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-72731	psi-mi:"MI:0469"(intact)	-	-	delivery method:Q9Z1S8 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2020/01/07	rogid:DV50jtkpOksZpaqjllQRhmpYkvk10090	rogid:8DeHwUGLPW9WyTBXtSMriRcqRqY10090	intact-crc:21B2904C9DA88411|rigid:L9ZERF3YZ+bhMjV9srq+aNycPCw	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z1S8	uniprotkb:P98083	intact:EBI-641738|uniprotkb:Q9R1X3	intact:EBI-300201|ensembl:ENSMUSP00000091940|uniprotkb:Q3U2Q7|uniprotkb:Q8BFY3|uniprotkb:Q8K4C6|uniprotkb:Q8K4C7	psi-mi:gab2_mouse(display_long)|uniprotkb:Growth factor receptor bound protein 2-associated protein 2(gene name synonym)|uniprotkb:GRB2-associated binder 2(gene name synonym)|uniprotkb:PH domain-containing adaptor molecule p97(gene name synonym)|uniprotkb:Gab2(gene name)|psi-mi:Gab2(display_short)	psi-mi:shc1_mouse(display_long)|uniprotkb:ShcA(gene name synonym)|uniprotkb:Shc1(gene name)|psi-mi:Shc1(display_short)|uniprotkb:Shc(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642779|imex:IM-8314-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-MMU-109704|reactome:R-MMU-1433557|reactome:R-MMU-2730905|reactome:R-MMU-8853659|reactome:R-MMU-912526|dip:DIP-41351N|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|reactome:R-MMU-9674555|reactome:R-MMU-1257604|reactome:R-MMU-6811558|reactome:R-MMU-9607240	ensembl:ENSMUST00000094378(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENSMUSG00000042626(gene)|go:"GO:0010008"(endosome membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|mint:P98083|reactome:R-MMU-1250196|reactome:R-MMU-1250347|reactome:R-MMU-167044|reactome:R-MMU-180336|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2428933|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1990839"(response to endothelin)|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354192|reactome:R-MMU-512988|reactome:R-MMU-5654688|reactome:R-MMU-5654699|reactome:R-MMU-5654704|reactome:R-MMU-5654719|reactome:R-MMU-5673001|reactome:R-MMU-74749|reactome:R-MMU-74751|interpro:IPR000980(SH2 motif)|reactome:R-MMU-8851805|reactome:R-MMU-8853659|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|reactome:R-MMU-8983432|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|reactome:R-MMU-9009391|reactome:R-MMU-9020558|reactome:R-MMU-9027284|reactome:R-MMU-9674555|reactome:R-MMU-912526|refseq:NP_001106802.1|refseq:NP_035498.2|dip:DIP-271N	psi-mi:"MI:0469"(intact)	-	-	delivery method:Q9Z1S8 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2020/01/07	rogid:DV50jtkpOksZpaqjllQRhmpYkvk10090	rogid:BksNa7XxzDyhK8y6ZdU5tz9CLUU10090	intact-crc:21B2904C9DA88411|rigid:L9ZERF3YZ+bhMjV9srq+aNycPCw	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z1S8	uniprotkb:O08908	intact:EBI-641738|uniprotkb:Q9R1X3	intact:EBI-643570|ensembl:ENSMUSP00000034296|uniprotkb:Q5U3K7	psi-mi:gab2_mouse(display_long)|uniprotkb:Growth factor receptor bound protein 2-associated protein 2(gene name synonym)|uniprotkb:GRB2-associated binder 2(gene name synonym)|uniprotkb:PH domain-containing adaptor molecule p97(gene name synonym)|uniprotkb:Gab2(gene name)|psi-mi:Gab2(display_short)	psi-mi:p85b_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)|uniprotkb:Pik3r2(gene name)|psi-mi:Pik3r2(display_short)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642779|imex:IM-8314-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-MMU-109704|reactome:R-MMU-1433557|reactome:R-MMU-2730905|reactome:R-MMU-8853659|reactome:R-MMU-912526|dip:DIP-41351N|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|reactome:R-MMU-9674555|reactome:R-MMU-1257604|reactome:R-MMU-6811558|reactome:R-MMU-9607240	ensembl:ENSMUSG00000031834(gene)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|ensembl:ENSMUST00000034296(transcript)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005925"(focal adhesion)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0030971"(receptor tyrosine kinase binding)|refseq:NP_032867.2|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|rcsb pdb:2Y3A|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-6811558|reactome:R-MMU-512988|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9696264|reactome:R-MMU-5673001|reactome:R-MMU-9696270|reactome:R-MMU-9696273	psi-mi:"MI:0469"(intact)	-	-	delivery method:Q9Z1S8 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2020/01/07	rogid:DV50jtkpOksZpaqjllQRhmpYkvk10090	rogid:8SNYg9Yr1SPNGhxsho1rANQT/Ks10090	intact-crc:21B2904C9DA88411|rigid:L9ZERF3YZ+bhMjV9srq+aNycPCw	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z1S8	uniprotkb:P06151	intact:EBI-641738|uniprotkb:Q9R1X3	intact:EBI-444940|ensembl:ENSMUSP00000036386|ensembl:ENSMUSP00000103267	psi-mi:gab2_mouse(display_long)|uniprotkb:Growth factor receptor bound protein 2-associated protein 2(gene name synonym)|uniprotkb:GRB2-associated binder 2(gene name synonym)|uniprotkb:PH domain-containing adaptor molecule p97(gene name synonym)|uniprotkb:Gab2(gene name)|psi-mi:Gab2(display_short)	psi-mi:ldha_mouse(display_long)|uniprotkb:LDH muscle subunit(gene name synonym)|uniprotkb:Ldha(gene name)|psi-mi:Ldha(display_short)|uniprotkb:Ldh-1(gene name synonym)|uniprotkb:Ldh1(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642779|imex:IM-8314-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-MMU-109704|reactome:R-MMU-1433557|reactome:R-MMU-2730905|reactome:R-MMU-8853659|reactome:R-MMU-912526|dip:DIP-41351N|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|reactome:R-MMU-9674555|reactome:R-MMU-1257604|reactome:R-MMU-6811558|reactome:R-MMU-9607240	refseq:NP_034829.1|ensembl:ENSMUSG00000063229(gene)|ensembl:ENSMUST00000005051(transcript)|ensembl:ENSMUST00000048209(transcript)|go:"GO:0004457"(lactate dehydrogenase activity)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0019244"(lactate biosynthetic process from pyruvate)|go:"GO:0019661"(glucose catabolic process to lactate via pyruvate)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0042802"(identical protein binding)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|mint:P06151|reactome:R-MMU-70268	psi-mi:"MI:0469"(intact)	-	-	delivery method:Q9Z1S8 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2020/01/07	rogid:DV50jtkpOksZpaqjllQRhmpYkvk10090	rogid:IErFuOIWq53/XyIxWgUyVi76VnM10090	intact-crc:21B2904C9DA88411|rigid:L9ZERF3YZ+bhMjV9srq+aNycPCw	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Z1S8	uniprotkb:P63101	intact:EBI-641738|uniprotkb:Q9R1X3	intact:EBI-354751|uniprotkb:P35215|uniprotkb:P70197|uniprotkb:P97286|uniprotkb:Q3TSF1|uniprotkb:Q5EBQ1|ensembl:ENSMUSP00000022894|ensembl:ENSMUSP00000105990|ensembl:ENSMUSP00000105991	psi-mi:gab2_mouse(display_long)|uniprotkb:Growth factor receptor bound protein 2-associated protein 2(gene name synonym)|uniprotkb:GRB2-associated binder 2(gene name synonym)|uniprotkb:PH domain-containing adaptor molecule p97(gene name synonym)|uniprotkb:Gab2(gene name)|psi-mi:Gab2(display_short)	psi-mi:1433z_mouse(display_long)|uniprotkb:Ywhaz(gene name)|psi-mi:Ywhaz(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:SEZ-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642779|imex:IM-8314-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-MMU-109704|reactome:R-MMU-1433557|reactome:R-MMU-2730905|reactome:R-MMU-8853659|reactome:R-MMU-912526|dip:DIP-41351N|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|reactome:R-MMU-9674555|reactome:R-MMU-1257604|reactome:R-MMU-6811558|reactome:R-MMU-9607240	refseq:NP_001240734.1|refseq:NP_001240735.1|refseq:NP_035870.1|refseq:XP_011243654.1|ensembl:ENSMUSG00000022285(gene)|ensembl:ENSMUST00000110361(transcript)|ensembl:ENSMUST00000110362(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0003016"(respiratory system process)|ensembl:ENSMUST00000022894(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0010941"(regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035148"(tube formation)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P63101|reactome:R-MMU-111447|reactome:R-MMU-3769402|reactome:R-MMU-392517|reactome:R-MMU-430116|reactome:R-MMU-450604|reactome:R-MMU-512988|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9013700|reactome:R-MMU-9614399|dip:DIP-31894N	psi-mi:"MI:0469"(intact)	-	-	delivery method:Q9Z1S8 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2020/01/07	rogid:DV50jtkpOksZpaqjllQRhmpYkvk10090	rogid:v2N95HO8sYRWEg2gFtWiYajP1Sc10090	intact-crc:21B2904C9DA88411|rigid:L9ZERF3YZ+bhMjV9srq+aNycPCw	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q60631	uniprotkb:P59108	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	intact:EBI-2642823|uniprotkb:Q8K1D7|ensembl:ENSMUSP00000045755	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:cpne2_mouse(display_long)|uniprotkb:Copine II(gene name synonym)|uniprotkb:Cpne2(gene name)|psi-mi:Cpne2(display_short)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642822|imex:IM-8314-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	refseq:NP_705727.1|ensembl:ENSMUSG00000034361(gene)|ensembl:ENSMUST00000048653(transcript)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR010734(Copine)|interpro:IPR035892|interpro:IPR036465|interpro:IPR037768|go:"GO:0071277"(cellular response to calcium ion)	psi-mi:"MI:0469"(intact)	-	-	delivery method:Q60631|figure legend:Supplementary table 2 and 10, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	rogid:yGpBarHzlgZXvt3AEX+5HbM/ACA10090	intact-crc:65884FC7C6B9F6D9|rigid:K4YOahT6f88rw2l0nPh2IRm1Y1M	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q60631	uniprotkb:P11274	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	intact:EBI-712838|intact:EBI-28971369|ensembl:ENSP00000303507|uniprotkb:P78501|uniprotkb:Q12842|uniprotkb:Q4LE80|uniprotkb:Q6NZI3	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:bcr_human(display_long)|uniprotkb:Renal carcinoma antigen NY-REN-26(gene name synonym)|uniprotkb:BCR(gene name)|psi-mi:BCR(display_short)|uniprotkb:BCR1(gene name synonym)|uniprotkb:D22S11(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642822|imex:IM-8314-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	ensembl:ENSG00000186716(gene)|ensembl:ENST00000305877(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030424"(axon)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0043197"(dendritic spine)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000198(RhoGAP)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR015123(Bcr-Abl oncoprotein oligomerisation)|interpro:IPR035892|interpro:IPR035899|interpro:IPR036481|interpro:IPR037769|rcsb pdb:1K1F|rcsb pdb:2AIN|rcsb pdb:5N6R|rcsb pdb:5N7E|rcsb pdb:5OC7|reactome:R-HSA-1839117|reactome:R-HSA-5655302|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|mint:P11274|ensembl:ENSP00000303507|ensembl:ENST00000359540|ensembl:ENSP00000352535|refseq:NP_004318.3|refseq:NP_067585.2	psi-mi:"MI:0469"(intact)	-	-	delivery method:Q60631|figure legend:Supplementary table 2 and 10, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	rogid:U2+lPQ5c2dVW2MPLvknA0Bbg4fA9606	intact-crc:65884FC7C6B9F6D9|rigid:K4YOahT6f88rw2l0nPh2IRm1Y1M	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q60631	uniprotkb:Q148Q7	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	intact:EBI-2642832	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:q148q7_mouse(display_long)|uniprotkb:Krt90(gene name)|psi-mi:Krt90(display_short)|uniprotkb:4732456N10Rik(gene name synonym)|uniprotkb:Ket90(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642822|imex:IM-8314-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	interpro:IPR018039|interpro:IPR003054(Type II keratin)|interpro:IPR032444|go:"GO:0045095"(keratin filament)|interpro:IPR039008	psi-mi:"MI:0469"(intact)	-	-	delivery method:Q60631|figure legend:Supplementary table 2 and 10, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	rogid:iDtgZLXMfbuRgH5nwdU2pHvL3ro10090	intact-crc:65884FC7C6B9F6D9|rigid:K4YOahT6f88rw2l0nPh2IRm1Y1M	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q60631	uniprotkb:Q3UHC2	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	intact:EBI-2642847|uniprotkb:Q8BUY0|uniprotkb:Q6GQR9|uniprotkb:Q8BU93|uniprotkb:Q6ZPI4|uniprotkb:Q6NZF5|uniprotkb:Q66JQ4|uniprotkb:Q8R085|uniprotkb:Q8BVV2|uniprotkb:Q8BKP3|uniprotkb:Q3U476|ensembl:ENSMUSP00000015277	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:lrrk1_mouse(display_long)|uniprotkb:Lrrk1(gene name)|psi-mi:Lrrk1(display_short)|uniprotkb:Kiaa1790(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642822|imex:IM-8314-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	refseq:NP_666303.3|ensembl:ENSMUSG00000015133(gene)|ensembl:ENSMUST00000015277(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0042802"(identical protein binding)|go:"GO:0045453"(bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002110(Ankyrin)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011044(Quinoprotein amine dehydrogenase, beta chain-like)|interpro:IPR020683|interpro:IPR020859|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036770|mint:Q3UHC2	psi-mi:"MI:0469"(intact)	-	-	delivery method:Q60631|figure legend:Supplementary table 2 and 10, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	rogid:WhnjdTZfDpa83ubX/6k7teG1+8U10090	intact-crc:65884FC7C6B9F6D9|rigid:K4YOahT6f88rw2l0nPh2IRm1Y1M	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q60631	uniprotkb:A2BGG7	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	intact:EBI-2642868|ensembl:ENSMUSP00000117225	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:a2bgg7_mouse(display_long)|uniprotkb:Ybx1(gene name)|psi-mi:Ybx1(display_short)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642822|imex:IM-8314-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	ensembl:ENSMUSG00000028639(gene)|ensembl:ENSMUST00000127737(transcript)	psi-mi:"MI:0469"(intact)	-	-	delivery method:Q60631|figure legend:Supplementary table 2 and 10, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	rogid:/3gY3K8sqvIu4G7HSb9MgBeLmCI10090	intact-crc:65884FC7C6B9F6D9|rigid:K4YOahT6f88rw2l0nPh2IRm1Y1M	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9NZM3	uniprotkb:P63087	intact:EBI-308689|uniprotkb:O95062|uniprotkb:Q15812|uniprotkb:Q9HAK4|uniprotkb:Q9NXE6|uniprotkb:Q9NYG0|uniprotkb:Q9NZM2|uniprotkb:Q9ULG4|ensembl:ENSP00000347244	intact:EBI-80040|uniprotkb:O09186|uniprotkb:O09189|uniprotkb:P37139|uniprotkb:Q64679|ensembl:ENSMUSP00000099587	psi-mi:itsn2_human(display_long)|uniprotkb:ITSN2(gene name)|psi-mi:ITSN2(display_short)|uniprotkb:KIAA1256(gene name synonym)|uniprotkb:SH3D1B(gene name synonym)|uniprotkb:SWAP(gene name synonym)|uniprotkb:SH3 domain-containing protein 1B(gene name synonym)|uniprotkb:SH3P18(gene name synonym)|uniprotkb:SH3P18-like WASP-associated protein(gene name synonym)	psi-mi:pp1g_mouse(display_long)|uniprotkb:Ppp1cc(gene name)|psi-mi:Ppp1cc(display_short)|uniprotkb:Protein phosphatase 1C catalytic subunit(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642876|imex:IM-8314-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000347244|ensembl:ENST00000361999|ensembl:ENSP00000354561|ensembl:ENST00000406921|ensembl:ENSP00000384499|ensembl:ENSG00000198399(gene)|ensembl:ENST00000355123(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0016197"(endosomal transport)|go:"GO:0030154"(cell differentiation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|go:"GO:0150007"(clathrin-dependent synaptic vesicle endocytosis)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018247|interpro:IPR027029|interpro:IPR035737|interpro:IPR035738|interpro:IPR035739|interpro:IPR035740|interpro:IPR035741|interpro:IPR035892|interpro:IPR035899|interpro:IPR036028|rcsb pdb:1J3T|rcsb pdb:1UDL|rcsb pdb:1UE9|rcsb pdb:1UFF|rcsb pdb:1UHF|rcsb pdb:3GF9|rcsb pdb:3JZY|rcsb pdb:4IIO|reactome:R-HSA-8856825|reactome:R-HSA-8856828|refseq:NP_006268.2|refseq:NP_062541.3|refseq:NP_671494.2	go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051301"(cell division)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037981|rcsb pdb:4V0U|rcsb pdb:4V0V|rcsb pdb:4V0W|rcsb pdb:4V0X|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-68877|reactome:R-MMU-9648025|go:"GO:0005856"(cytoskeleton)|ensembl:ENSMUSG00000004455(gene)|ensembl:ENSMUST00000102528(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_038664.2|refseq:XP_006508478.1|refseq:XP_006530263.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary table 2, Fig 1 and 2|delivery method:Q9NZM3 infection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:dxUqeWmW1uwOqgZ89UhT98/pt809606	rogid:67YjuOIxqIl6Qj+bQnfLBo4iRAg10090	intact-crc:83CC7AD005C57180|rigid:v1xts+4s+WOGFnmaVCllkqF1+pY	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9NZM3	uniprotkb:Q60902	intact:EBI-308689|uniprotkb:O95062|uniprotkb:Q15812|uniprotkb:Q9HAK4|uniprotkb:Q9NXE6|uniprotkb:Q9NYG0|uniprotkb:Q9NZM2|uniprotkb:Q9ULG4|ensembl:ENSP00000347244	intact:EBI-443931|ensembl:ENSMUSP00000129739|uniprotkb:Q3U7L9|uniprotkb:Q8CB60|uniprotkb:Q8CB70|uniprotkb:Q3UIS9|uniprotkb:Q91WH8	psi-mi:itsn2_human(display_long)|uniprotkb:ITSN2(gene name)|psi-mi:ITSN2(display_short)|uniprotkb:KIAA1256(gene name synonym)|uniprotkb:SH3D1B(gene name synonym)|uniprotkb:SWAP(gene name synonym)|uniprotkb:SH3 domain-containing protein 1B(gene name synonym)|uniprotkb:SH3P18(gene name synonym)|uniprotkb:SH3P18-like WASP-associated protein(gene name synonym)	psi-mi:ep15r_mouse(display_long)|uniprotkb:Eps15-related protein(gene name synonym)|uniprotkb:Epidermal growth factor receptor pathway substrate 15-related sequence(gene name synonym)|uniprotkb:Eps15l1(gene name)|psi-mi:Eps15l1(display_short)|uniprotkb:Eps15-rs(gene name synonym)|uniprotkb:Eps15R(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642876|imex:IM-8314-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000347244|ensembl:ENST00000361999|ensembl:ENSP00000354561|ensembl:ENST00000406921|ensembl:ENSP00000384499|ensembl:ENSG00000198399(gene)|ensembl:ENST00000355123(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0016197"(endosomal transport)|go:"GO:0030154"(cell differentiation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|go:"GO:0150007"(clathrin-dependent synaptic vesicle endocytosis)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018247|interpro:IPR027029|interpro:IPR035737|interpro:IPR035738|interpro:IPR035739|interpro:IPR035740|interpro:IPR035741|interpro:IPR035892|interpro:IPR035899|interpro:IPR036028|rcsb pdb:1J3T|rcsb pdb:1UDL|rcsb pdb:1UE9|rcsb pdb:1UFF|rcsb pdb:1UHF|rcsb pdb:3GF9|rcsb pdb:3JZY|rcsb pdb:4IIO|reactome:R-HSA-8856825|reactome:R-HSA-8856828|refseq:NP_006268.2|refseq:NP_062541.3|refseq:NP_671494.2	ensembl:ENSMUSG00000006276(gene)|ensembl:ENSMUST00000163643(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0016197"(endosomal transport)|go:"GO:0030132"(clathrin coat of coated pit)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q60902|reactome:R-MMU-182971|reactome:R-MMU-8856825|reactome:R-MMU-8856828|refseq:NP_001116304.1|refseq:NP_031970.2|refseq:NP_001276788.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary table 2, Fig 1 and 2|delivery method:Q9NZM3 infection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:dxUqeWmW1uwOqgZ89UhT98/pt809606	rogid:8Xag/aZPFGDnwUbio3gkHL3nMes10090	intact-crc:83CC7AD005C57180|rigid:v1xts+4s+WOGFnmaVCllkqF1+pY	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P97465	uniprotkb:Q99M51	intact:EBI-914917|uniprotkb:Q9R213|ensembl:ENSMUSP00000087079	intact:EBI-642202|uniprotkb:O55032|uniprotkb:Q9Z279|intact:EBI-2642686|intact:EBI-643937|ensembl:ENSMUSP00000112221	psi-mi:dok1_mouse(display_long)|uniprotkb:Downstream of tyrosine kinase 1(gene name synonym)|uniprotkb:"p62(dok)"(gene name synonym)|uniprotkb:Dok1(gene name)|psi-mi:Dok1(display_short)|uniprotkb:Dok(gene name synonym)	psi-mi:nck1_mouse(display_long)|uniprotkb:Nck1(gene name)|psi-mi:Nck1(display_short)|uniprotkb:NCK adaptor protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642886|imex:IM-8314-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034200.4|refseq:NP_001278728.1|ensembl:ENSMUSG00000068335(gene)|ensembl:ENSMUST00000089651(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0043409"(negative regulation of MAPK cascade)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:P97465|rcsb pdb:1P5T|rcsb pdb:1UEF|reactome:R-MMU-8849469|reactome:R-MMU-8853659	refseq:NP_035008.2|refseq:XP_006510903.1|ensembl:ENSMUSG00000032475(gene)|ensembl:ENSMUST00000116522(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-373753|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-983695|dip:DIP-37524N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:7GKYnqXCQie+Z26maTxfYF4ShNE10090	rogid:uq7YGxP9zh6bhhrOJdJa9D+3O2g10090	intact-crc:3528238214F86642|rigid:O9Dgj0+MVjGuHRLq7UKInE7W79c	false	-	tag:?-?	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O35177	uniprotkb:P68040	intact:EBI-2642891|uniprotkb:Q8BJL8|uniprotkb:Q8BMI9|uniprotkb:Q8BM94|uniprotkb:Q8BK90|uniprotkb:Q99KE7|uniprotkb:Q8BL52|ensembl:ENSMUSP00000021794	intact:EBI-296749|ensembl:ENSMUSP00000020640|uniprotkb:P25388|uniprotkb:P99049|intact:EBI-1183965|uniprotkb:Q3THP0|uniprotkb:Q3THY7|uniprotkb:Q3TKQ0|uniprotkb:Q3TW88|uniprotkb:Q5NCC5|uniprotkb:Q5NCC6|uniprotkb:Q9CSQ0|uniprotkb:Q9ERM6	psi-mi:casl_mouse(display_long)|uniprotkb:Casl(gene name synonym)|uniprotkb:CRK-associated substrate-related protein(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 9(gene name synonym)|uniprotkb:p105(gene name synonym)|uniprotkb:Nedd9(gene name)|psi-mi:Nedd9(display_short)	psi-mi:rack1_mouse(display_long)|uniprotkb:p205(gene name synonym)|uniprotkb:Receptor of activated protein kinase C 1(gene name synonym)|uniprotkb:12-3(gene name synonym)|uniprotkb:Gnb2-rs1(gene name synonym)|uniprotkb:Gnb2l1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-2-like 1(gene name synonym)|uniprotkb:Rack1(gene name)|psi-mi:Rack1(display_short)|uniprotkb:Receptor for activated C kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642901|imex:IM-8314-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001104794.1|refseq:NP_059492.3|ensembl:ENSMUSG00000021365(gene)|ensembl:ENSMUST00000021794(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0040008"(regulation of growth)|go:"GO:0051301"(cell division)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090527"(actin filament reorganization)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001452(Src homology-3)|interpro:IPR014928(Serine rich protein interaction)|interpro:IPR021901|interpro:IPR035746|interpro:IPR036028|interpro:IPR037362|interpro:IPR038319|dip:DIP-57058N	go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1990630"(IRE1-RACK1-PP2A complex)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000543"(positive regulation of gastrulation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P68040|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5626978|go:"GO:0072344"(rescue of stalled ribosome)|ensembl:ENSMUSG00000020372(gene)|ensembl:ENSMUST00000020640(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007369"(gastrulation)|go:"GO:0008104"(protein localization)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030292"(protein tyrosine kinase inhibitor activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030496"(midbody)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0006412"(translation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042998"(positive regulation of Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043473"(pigmentation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044297"(cell body)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051302"(regulation of cell division)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|refseq:NP_032169.1	psi-mi:"MI:0469"(intact)	-	-	delivery method:O35177 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:M/DE7RwmYizqy+SKJvp0M1f1odY10090	rogid:LXHlhPtxUzHJNncoPteGw2iXsFg10090	intact-crc:2B6D21181161F6E4|rigid:r3GK9CkPoLjRHNYGPvIC/l7mWGg	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O35177	uniprotkb:Q9JMH9	intact:EBI-2642891|uniprotkb:Q8BJL8|uniprotkb:Q8BMI9|uniprotkb:Q8BM94|uniprotkb:Q8BK90|uniprotkb:Q99KE7|uniprotkb:Q8BL52|ensembl:ENSMUSP00000021794	intact:EBI-643214|uniprotkb:Q3TBB2|uniprotkb:Q3UH48|uniprotkb:Q3UV60|uniprotkb:Q5SYN8|uniprotkb:Q5SYN9|uniprotkb:Q5SYP0|uniprotkb:Q5SYP1|uniprotkb:Q811D7|ensembl:ENSMUSP00000104012|uniprotkb:Q5QD54|uniprotkb:Q5QD55|uniprotkb:Q5QD56	psi-mi:casl_mouse(display_long)|uniprotkb:Casl(gene name synonym)|uniprotkb:CRK-associated substrate-related protein(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 9(gene name synonym)|uniprotkb:p105(gene name synonym)|uniprotkb:Nedd9(gene name)|psi-mi:Nedd9(display_short)	psi-mi:my18a_mouse(display_long)|uniprotkb:Myosin containing a PDZ domain(gene name synonym)|uniprotkb:Molecule associated with JAK3 N-terminus(gene name synonym)|uniprotkb:Myo18a(gene name)|psi-mi:Myo18a(display_short)|uniprotkb:Myspdz(gene name synonym)|uniprotkb:Surfactant protein receptor SP-R210(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642901|imex:IM-8314-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001104794.1|refseq:NP_059492.3|ensembl:ENSMUSG00000021365(gene)|ensembl:ENSMUST00000021794(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0040008"(regulation of growth)|go:"GO:0051301"(cell division)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090527"(actin filament reorganization)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001452(Src homology-3)|interpro:IPR014928(Serine rich protein interaction)|interpro:IPR021901|interpro:IPR035746|interpro:IPR036028|interpro:IPR037362|interpro:IPR038319|dip:DIP-57058N	refseq:NP_035716.1|refseq:XP_006533667.1|refseq:XP_006533669.1|refseq:XP_006533677.2|refseq:NP_001278141.1|refseq:NP_001278142.1|refseq:NP_001278143.1|refseq:NP_001278144.1|go:"GO:0005903"(brush border)|go:"GO:0007030"(Golgi organization)|go:"GO:0016459"(myosin complex)|go:"GO:0016477"(cell migration)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0042641"(actomyosin)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043531"(ADP binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048194"(Golgi vesicle budding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:0090164"(asymmetric Golgi ribbon formation)|go:"GO:1903028"(positive regulation of opsonization)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR027417|interpro:IPR031244|interpro:IPR036034|interpro:IPR036064|interpro:IPR036961|mint:Q9JMH9|ensembl:ENSMUSG00000000631(gene)|ensembl:ENSMUST00000108375(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005856"(cytoskeleton)|refseq:XP_017170115.1	psi-mi:"MI:0469"(intact)	-	-	delivery method:O35177 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:M/DE7RwmYizqy+SKJvp0M1f1odY10090	rogid:TZQzZ2x1aphZBaHL6GPOTcdJzco10090	intact-crc:2B6D21181161F6E4|rigid:r3GK9CkPoLjRHNYGPvIC/l7mWGg	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O35177	uniprotkb:Q64010	intact:EBI-2642891|uniprotkb:Q8BJL8|uniprotkb:Q8BMI9|uniprotkb:Q8BM94|uniprotkb:Q8BK90|uniprotkb:Q99KE7|uniprotkb:Q8BL52|ensembl:ENSMUSP00000021794	intact:EBI-2906540|ensembl:ENSMUSP00000017920	psi-mi:casl_mouse(display_long)|uniprotkb:Casl(gene name synonym)|uniprotkb:CRK-associated substrate-related protein(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 9(gene name synonym)|uniprotkb:p105(gene name synonym)|uniprotkb:Nedd9(gene name)|psi-mi:Nedd9(display_short)	psi-mi:crk_mouse(display_long)|uniprotkb:Crk(gene name)|psi-mi:Crk(display_short)|uniprotkb:Crko(gene name synonym)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642901|imex:IM-8314-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001104794.1|refseq:NP_059492.3|ensembl:ENSMUSG00000021365(gene)|ensembl:ENSMUST00000021794(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0040008"(regulation of growth)|go:"GO:0051301"(cell division)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090527"(actin filament reorganization)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001452(Src homology-3)|interpro:IPR014928(Serine rich protein interaction)|interpro:IPR021901|interpro:IPR035746|interpro:IPR036028|interpro:IPR037362|interpro:IPR038319|dip:DIP-57058N	refseq:NP_598417.2|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|ensembl:ENSMUSG00000017776(gene)|ensembl:ENSMUST00000017920(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901652"(response to peptide)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|rcsb pdb:1B07|rcsb pdb:1CKA|rcsb pdb:1CKB|rcsb pdb:1JU5|rcsb pdb:1M30|rcsb pdb:1M3A|rcsb pdb:1M3B|rcsb pdb:1M3C|rcsb pdb:2GGR|rcsb pdb:5IH2|rcsb pdb:5JN0|rcsb pdb:5L23|reactome:R-MMU-170984|reactome:R-MMU-186763|reactome:R-MMU-2029482|reactome:R-MMU-372708|reactome:R-MMU-4420097|reactome:R-MMU-8849471|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-912631|go:"GO:0035685"(helper T cell diapedesis)|dip:DIP-57059N	psi-mi:"MI:0469"(intact)	-	-	delivery method:O35177 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:M/DE7RwmYizqy+SKJvp0M1f1odY10090	rogid:e9eU7+wkCP5FNnenBlIixVbL7UM10090	intact-crc:2B6D21181161F6E4|rigid:r3GK9CkPoLjRHNYGPvIC/l7mWGg	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:D3ZMK9	uniprotkb:P41241	intact:EBI-2642917|ensembl:ENSRNOP00000015166	intact:EBI-2553183|uniprotkb:Q80WU4|uniprotkb:Q8VCW1|ensembl:ENSMUSP00000034863|ensembl:ENSMUSP00000150590|ensembl:ENSMUSP00000150984|uniprotkb:Q03143	psi-mi:prag1_rat(display_long)|uniprotkb:Prag1(gene name)|psi-mi:Prag1(display_short)|uniprotkb:Pragmin(gene name synonym)|uniprotkb:PEAK1-related kinase-activating pseudokinase 1(gene name synonym)|uniprotkb:Pragma of Rnd2(gene name synonym)	psi-mi:csk_mouse(display_long)|uniprotkb:Csk(gene name)|psi-mi:Csk(display_short)|uniprotkb:C-Src kinase(gene name synonym)|uniprotkb:Protein-tyrosine kinase MPK-2(gene name synonym)|uniprotkb:p50CSK(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642916|imex:IM-8314-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001100785.1|rgd:1311793|ensembl:ENSRNOG00000011407(gene)|ensembl:ENSRNOT00000015166(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016477"(cell migration)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|rcsb pdb:6EWX|refseq:XP_017455620.1|refseq:XP_017455621.1	refseq:NP_001291690.1|go:"GO:0016740"(transferase activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005911"(cell-cell junction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048709"(oligodendrocyte differentiation)|ensembl:ENSMUSG00000032312(gene)|ensembl:ENSMUST00000034863(transcript)|ensembl:ENSMUST00000215396(transcript)|ensembl:ENSMUST00000217314(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|go:"GO:0050765"(negative regulation of phagocytosis)|interpro:IPR035027|interpro:IPR036028|interpro:IPR036860|rcsb pdb:1JEG|reactome:R-MMU-180292|reactome:R-MMU-202427|reactome:R-MMU-354192|reactome:R-MMU-389948|reactome:R-MMU-5674135|reactome:R-MMU-9013407|reactome:R-MMU-9706369|refseq:NP_031809.2|refseq:XP_006510864.1|refseq:XP_006510865.1	psi-mi:"MI:0469"(intact)	-	-	delivery method:D3ZMK9 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:aokz+1urxJgldl4U+qJgQdJFmi810116	rogid:2unY4cD7qXpvYgIJ59ajuZ/FSiQ10090	intact-crc:C62F4E4D2CF04F28|rigid:8y+O31WNgSenhFT1C71s4rWXtzA	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:D3ZMK9	uniprotkb:Q7TPR4	intact:EBI-2642917|ensembl:ENSRNOP00000015166	intact:EBI-774010|ensembl:ENSMUSP00000021554	psi-mi:prag1_rat(display_long)|uniprotkb:Prag1(gene name)|psi-mi:Prag1(display_short)|uniprotkb:Pragmin(gene name synonym)|uniprotkb:PEAK1-related kinase-activating pseudokinase 1(gene name synonym)|uniprotkb:Pragma of Rnd2(gene name synonym)	psi-mi:actn1_mouse(display_long)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)|uniprotkb:Actn1(gene name)|psi-mi:Actn1(display_short)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642916|imex:IM-8314-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001100785.1|rgd:1311793|ensembl:ENSRNOG00000011407(gene)|ensembl:ENSRNOT00000015166(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016477"(cell migration)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|rcsb pdb:6EWX|refseq:XP_017455620.1|refseq:XP_017455621.1	refseq:NP_598917.1|ensembl:ENSMUSG00000015143(gene)|ensembl:ENSMUST00000021554(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005519"(cytoskeletal regulatory protein binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0017166"(vinculin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030141"(secretory granule)|go:"GO:0030220"(platelet formation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0032127"(dense core granule membrane)|go:"GO:0036344"(platelet morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051639"(actin filament network formation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:Q7TPR4|rcsb pdb:6C0A|reactome:R-MMU-114608|reactome:R-MMU-446388|reactome:R-MMU-9013405|reactome:R-MMU-9013418|reactome:R-MMU-9035034	psi-mi:"MI:0469"(intact)	-	-	delivery method:D3ZMK9 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:aokz+1urxJgldl4U+qJgQdJFmi810116	rogid:02QPrtqpFY8sgQvjRRI5wmCbNjU10090	intact-crc:C62F4E4D2CF04F28|rigid:8y+O31WNgSenhFT1C71s4rWXtzA	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P98083-2	uniprotkb:Q60631	intact:EBI-1019301|ensembl:ENSMUSP00000035361|ensembl:ENSMUSP00000140336|intact:EBI-7533879|intact:EBI-7731816|intact:EBI-7533245|intact:EBI-7533434|intact:EBI-7533730|intact:MINT-4134573|intact:EBI-7533772|intact:EBI-7533825|intact:EBI-7731689|intact:EBI-7731891	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:p98083-2(display_long)|uniprotkb:p52(isoform synonym)|uniprotkb:Shc1(gene name)|psi-mi:Shc1(display_short)|uniprotkb:Shc(gene name synonym)|uniprotkb:ShcA(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642941|imex:IM-8314-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-300201(shc1_mouse)|ensembl:ENSMUSG00000042626(gene)|ensembl:ENSMUST00000039110(transcript)|ensembl:ENSMUST00000191485(transcript)	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	psi-mi:"MI:0469"(intact)	isoform-comment:Produced by alternative splicing.	-	delivery method:P98083-2 infection|figure legend:Supplementary table 2 and 10, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:dCSxqZGUS1aaz/pQk/kCP6+gfCg10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:1AC9AEC1E9BBAD0D|rigid:6zBMaGr2+hYJBQXfK/40de7nNI8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P98083-2	uniprotkb:Q9ES52	intact:EBI-1019301|ensembl:ENSMUSP00000035361|ensembl:ENSMUSP00000140336|intact:EBI-7533879|intact:EBI-7731816|intact:EBI-7533245|intact:EBI-7533434|intact:EBI-7533730|intact:MINT-4134573|intact:EBI-7533772|intact:EBI-7533825|intact:EBI-7731689|intact:EBI-7731891	intact:EBI-300210|ensembl:ENSMUSP00000127941|uniprotkb:Q3UPF9|uniprotkb:Q4U212|uniprotkb:Q61034|uniprotkb:Q61173|uniprotkb:Q61181|uniprotkb:Q9JKR7|uniprotkb:Q9JLF9|uniprotkb:Q9JLG0|uniprotkb:Q9QVN8|uniprotkb:Q9WUC2	psi-mi:p98083-2(display_long)|uniprotkb:p52(isoform synonym)|uniprotkb:Shc1(gene name)|psi-mi:Shc1(display_short)|uniprotkb:Shc(gene name synonym)|uniprotkb:ShcA(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)	psi-mi:ship1_mouse(display_long)|uniprotkb:Inpp5d(gene name)|psi-mi:Inpp5d(display_short)|uniprotkb:Ship(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase of 145 kDa(gene name synonym)|uniprotkb:p150Ship(gene name synonym)|uniprotkb:7a33(gene name synonym)|uniprotkb:Ship1(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase D(gene name synonym)|uniprotkb:Phosphatidylinositol-4,5-bisphosphate 5-phosphatase(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642941|imex:IM-8314-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-300201(shc1_mouse)|ensembl:ENSMUSG00000042626(gene)|ensembl:ENSMUST00000039110(transcript)|ensembl:ENSMUST00000191485(transcript)	ensembl:ENSMUSG00000026288(gene)|ensembl:ENSMUST00000169754(transcript)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030487"(inositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045659"(negative regulation of neutrophil differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR036860|go:"GO:0050777"(negative regulation of immune response)|rcsb pdb:6DLG|reactome:R-MMU-1660499|reactome:R-MMU-1855204|reactome:R-MMU-202424|reactome:R-MMU-210990|reactome:R-MMU-912526|refseq:NP_001103662.1|refseq:NP_001103663.1|refseq:NP_034696.2	psi-mi:"MI:0469"(intact)	isoform-comment:Produced by alternative splicing.	-	delivery method:P98083-2 infection|figure legend:Supplementary table 2 and 10, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:dCSxqZGUS1aaz/pQk/kCP6+gfCg10090	rogid:ipXHzUIAHLTMnjElS7ngcCqFuak10090	intact-crc:1AC9AEC1E9BBAD0D|rigid:6zBMaGr2+hYJBQXfK/40de7nNI8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P98083-2	uniprotkb:P68368	intact:EBI-1019301|ensembl:ENSMUSP00000035361|ensembl:ENSMUSP00000140336|intact:EBI-7533879|intact:EBI-7731816|intact:EBI-7533245|intact:EBI-7533434|intact:EBI-7533730|intact:MINT-4134573|intact:EBI-7533772|intact:EBI-7533825|intact:EBI-7731689|intact:EBI-7731891	intact:EBI-2642970|uniprotkb:Q3TY31|uniprotkb:P05215|ensembl:ENSMUSP00000140657	psi-mi:p98083-2(display_long)|uniprotkb:p52(isoform synonym)|uniprotkb:Shc1(gene name)|psi-mi:Shc1(display_short)|uniprotkb:Shc(gene name synonym)|uniprotkb:ShcA(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)	psi-mi:tba4a_mouse(display_long)|uniprotkb:Tuba4a(gene name)|psi-mi:Tuba4a(display_short)|uniprotkb:Tuba4(gene name synonym)|uniprotkb:Tubulin alpha-4 chain(gene name synonym)|uniprotkb:Alpha-tubulin 4(gene name synonym)|uniprotkb:Alpha-tubulin isotype M-alpha-4(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642941|imex:IM-8314-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-300201(shc1_mouse)|ensembl:ENSMUSG00000042626(gene)|ensembl:ENSMUST00000039110(transcript)|ensembl:ENSMUST00000191485(transcript)	refseq:NP_033473.1|ensembl:ENSMUSG00000026202(gene)|ensembl:ENSMUST00000186213(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P68368|reactome:R-MMU-114608|reactome:R-MMU-190840|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-437239|reactome:R-MMU-5610787|reactome:R-MMU-5617833|reactome:R-MMU-5620912|reactome:R-MMU-5620924|reactome:R-MMU-5626467|reactome:R-MMU-5663220|reactome:R-MMU-6807878|reactome:R-MMU-6811434|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8852276|reactome:R-MMU-8854518|reactome:R-MMU-8955332|reactome:R-MMU-9646399|reactome:R-MMU-9648025|reactome:R-MMU-9668328|reactome:R-MMU-983189|reactome:R-MMU-2132295	psi-mi:"MI:0469"(intact)	isoform-comment:Produced by alternative splicing.	-	delivery method:P98083-2 infection|figure legend:Supplementary table 2 and 10, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:dCSxqZGUS1aaz/pQk/kCP6+gfCg10090	rogid:6Oj9O8u7E6cLUJ1eT6y5slbk7uQ10090	intact-crc:1AC9AEC1E9BBAD0D|rigid:6zBMaGr2+hYJBQXfK/40de7nNI8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P98083-2	uniprotkb:P35831	intact:EBI-1019301|ensembl:ENSMUSP00000035361|ensembl:ENSMUSP00000140336|intact:EBI-7533879|intact:EBI-7731816|intact:EBI-7533245|intact:EBI-7533434|intact:EBI-7533730|intact:MINT-4134573|intact:EBI-7533772|intact:EBI-7533825|intact:EBI-7731689|intact:EBI-7731891	intact:EBI-2642957|uniprotkb:Q80UM4|ensembl:ENSMUSP00000030556	psi-mi:p98083-2(display_long)|uniprotkb:p52(isoform synonym)|uniprotkb:Shc1(gene name)|psi-mi:Shc1(display_short)|uniprotkb:Shc(gene name synonym)|uniprotkb:ShcA(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)	psi-mi:ptn12_mouse(display_long)|uniprotkb:Protein-tyrosine phosphatase P19(gene name synonym)|uniprotkb:Ptpn12(gene name)|psi-mi:Ptpn12(display_short)|uniprotkb:MPTP-PEST(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642941|imex:IM-8314-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-300201(shc1_mouse)|ensembl:ENSMUSG00000042626(gene)|ensembl:ENSMUST00000039110(transcript)|ensembl:ENSMUST00000191485(transcript)	refseq:NP_035333.2|ensembl:ENSMUSG00000028771(gene)|ensembl:ENSMUST00000030556(transcript)|go:"GO:0002102"(podosome)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042995"(cell projection)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012266(Protein-tyrosine phosphatase, non-receptor type-12)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|mint:P35831|reactome:R-MMU-1250196|reactome:R-MMU-182971|reactome:R-MMU-186797|reactome:R-MMU-8863795	psi-mi:"MI:0469"(intact)	isoform-comment:Produced by alternative splicing.	-	delivery method:P98083-2 infection|figure legend:Supplementary table 2 and 10, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:dCSxqZGUS1aaz/pQk/kCP6+gfCg10090	rogid:GgHiRVbQuJTf7k7PeNejGiKHybQ10090	intact-crc:1AC9AEC1E9BBAD0D|rigid:6zBMaGr2+hYJBQXfK/40de7nNI8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P98083-2	uniprotkb:Q3UHC2	intact:EBI-1019301|ensembl:ENSMUSP00000035361|ensembl:ENSMUSP00000140336|intact:EBI-7533879|intact:EBI-7731816|intact:EBI-7533245|intact:EBI-7533434|intact:EBI-7533730|intact:MINT-4134573|intact:EBI-7533772|intact:EBI-7533825|intact:EBI-7731689|intact:EBI-7731891	intact:EBI-2642847|uniprotkb:Q8BUY0|uniprotkb:Q6GQR9|uniprotkb:Q8BU93|uniprotkb:Q6ZPI4|uniprotkb:Q6NZF5|uniprotkb:Q66JQ4|uniprotkb:Q8R085|uniprotkb:Q8BVV2|uniprotkb:Q8BKP3|uniprotkb:Q3U476|ensembl:ENSMUSP00000015277	psi-mi:p98083-2(display_long)|uniprotkb:p52(isoform synonym)|uniprotkb:Shc1(gene name)|psi-mi:Shc1(display_short)|uniprotkb:Shc(gene name synonym)|uniprotkb:ShcA(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)	psi-mi:lrrk1_mouse(display_long)|uniprotkb:Lrrk1(gene name)|psi-mi:Lrrk1(display_short)|uniprotkb:Kiaa1790(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642941|imex:IM-8314-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-300201(shc1_mouse)|ensembl:ENSMUSG00000042626(gene)|ensembl:ENSMUST00000039110(transcript)|ensembl:ENSMUST00000191485(transcript)	refseq:NP_666303.3|ensembl:ENSMUSG00000015133(gene)|ensembl:ENSMUST00000015277(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0042802"(identical protein binding)|go:"GO:0045453"(bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002110(Ankyrin)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011044(Quinoprotein amine dehydrogenase, beta chain-like)|interpro:IPR020683|interpro:IPR020859|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036770|mint:Q3UHC2	psi-mi:"MI:0469"(intact)	isoform-comment:Produced by alternative splicing.	-	delivery method:P98083-2 infection|figure legend:Supplementary table 2 and 10, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:dCSxqZGUS1aaz/pQk/kCP6+gfCg10090	rogid:WhnjdTZfDpa83ubX/6k7teG1+8U10090	intact-crc:1AC9AEC1E9BBAD0D|rigid:6zBMaGr2+hYJBQXfK/40de7nNI8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P98083-2	uniprotkb:Q6P549	intact:EBI-1019301|ensembl:ENSMUSP00000035361|ensembl:ENSMUSP00000140336|intact:EBI-7533879|intact:EBI-7731816|intact:EBI-7533245|intact:EBI-7533434|intact:EBI-7533730|intact:MINT-4134573|intact:EBI-7533772|intact:EBI-7533825|intact:EBI-7731689|intact:EBI-7731891	intact:EBI-2642932|uniprotkb:Q9JLL7|uniprotkb:Q80YB9|uniprotkb:O08611|uniprotkb:Q0VDX5|ensembl:ENSMUSP00000048057|ensembl:ENSMUSP00000132883	psi-mi:p98083-2(display_long)|uniprotkb:p52(isoform synonym)|uniprotkb:Shc1(gene name)|psi-mi:Shc1(display_short)|uniprotkb:Shc(gene name synonym)|uniprotkb:ShcA(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)	psi-mi:ship2_mouse(display_long)|uniprotkb:Inppl1(gene name)|psi-mi:Inppl1(display_short)|uniprotkb:Ship2(gene name synonym)|uniprotkb:Inositol polyphosphate phosphatase-like protein 1(gene name synonym)|uniprotkb:AblSH3-binding protein(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642941|imex:IM-8314-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-300201(shc1_mouse)|ensembl:ENSMUSG00000042626(gene)|ensembl:ENSMUST00000039110(transcript)|ensembl:ENSMUST00000191485(transcript)	refseq:XP_011239984.1|refseq:NP_001116211.1|refseq:NP_034697.2|refseq:XP_006507454.1|ensembl:ENSMUSG00000032737(gene)|ensembl:ENSMUST00000035836(transcript)|ensembl:ENSMUST00000165052(transcript)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002376"(immune system process)|go:"GO:0003779"(actin binding)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0032868"(response to insulin)|go:"GO:0032957"(inositol trisphosphate metabolic process)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0097178"(ruffle assembly)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036691|interpro:IPR036860|mint:Q6P549|rcsb pdb:5ZRX|reactome:R-MMU-1660499|reactome:R-MMU-1855204|reactome:R-MMU-912526|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|refseq:XP_017177480.1	psi-mi:"MI:0469"(intact)	isoform-comment:Produced by alternative splicing.	-	delivery method:P98083-2 infection|figure legend:Supplementary table 2 and 10, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:dCSxqZGUS1aaz/pQk/kCP6+gfCg10090	rogid:NwJCQILox6pZfYrGno128U2xdpQ10090	intact-crc:1AC9AEC1E9BBAD0D|rigid:6zBMaGr2+hYJBQXfK/40de7nNI8	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88811	uniprotkb:Q99LI8	intact:EBI-2119154|uniprotkb:Q8C8Y4|uniprotkb:A2AU00|ensembl:ENSMUSP00000099820	intact:EBI-2119135|uniprotkb:Q61691|uniprotkb:Q8BQW3|ensembl:ENSMUSP00000101811	psi-mi:stam2_mouse(display_long)|uniprotkb:Stam2(gene name)|psi-mi:Stam2(display_short)|uniprotkb:Hbp(gene name synonym)|uniprotkb:Hrs-binding protein(gene name synonym)	psi-mi:hgs_mouse(display_long)|uniprotkb:Hgs(gene name)|psi-mi:Hgs(display_short)|uniprotkb:Hrs(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642981|imex:IM-8314-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062641.1|ensembl:ENSMUSG00000055371(gene)|ensembl:ENSMUST00000102759(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0015031"(protein transport)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001452(Src homology-3)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR035675|interpro:IPR036028|rcsb pdb:1UJ0|reactome:R-MMU-182971|reactome:R-MMU-5689880|reactome:R-MMU-6807004|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-9013420|reactome:R-MMU-917729	refseq:NP_001152800.1|refseq:NP_032270.3|dip:DIP-29102N|ensembl:ENSMUSG00000025793(gene)|ensembl:ENSMUST00000106205(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010324"(membrane invagination)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:1903543"(positive regulation of exosomal secretion)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR024641|reactome:R-MMU-182971|reactome:R-MMU-432720|reactome:R-MMU-5689880|reactome:R-MMU-6807004|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-9013420|reactome:R-MMU-917729|reactome:R-MMU-9706019	psi-mi:"MI:0469"(intact)	-	-	delivery method:O88811 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:ruTJW3K1aXdRx2pccUmFMxPy6+E10090	rogid:FS8KSHYryqJPQyo6wRWGNz86/kw10090	intact-crc:CC6837E1B1B5D777|rigid:bGQtK/XAZa8H73OpoG17k7uopeU	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88811	uniprotkb:Q9DAS9	intact:EBI-2119154|uniprotkb:Q8C8Y4|uniprotkb:A2AU00|ensembl:ENSMUSP00000099820	intact:EBI-1183804|uniprotkb:Q544P3|ensembl:ENSMUSP00000046557|ensembl:ENSMUSP00000109860|ensembl:ENSMUSP00000109862|ensembl:ENSMUSP00000109863|ensembl:ENSMUSP00000109864|ensembl:ENSMUSP00000109865|ensembl:ENSMUSP00000109866	psi-mi:stam2_mouse(display_long)|uniprotkb:Stam2(gene name)|psi-mi:Stam2(display_short)|uniprotkb:Hbp(gene name synonym)|uniprotkb:Hrs-binding protein(gene name synonym)	psi-mi:gbg12_mouse(display_long)|uniprotkb:Gng12(gene name)|psi-mi:Gng12(display_short)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642981|imex:IM-8314-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062641.1|ensembl:ENSMUSG00000055371(gene)|ensembl:ENSMUST00000102759(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0015031"(protein transport)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001452(Src homology-3)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR035675|interpro:IPR036028|rcsb pdb:1UJ0|reactome:R-MMU-182971|reactome:R-MMU-5689880|reactome:R-MMU-6807004|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-9013420|reactome:R-MMU-917729	refseq:NP_001171027.1|refseq:NP_001171028.1|refseq:NP_001171029.1|refseq:NP_001171030.1|refseq:NP_001171031.1|refseq:NP_079554.1|ensembl:ENSMUSG00000036402(gene)|ensembl:ENSMUST00000043148(transcript)|ensembl:ENSMUST00000114222(transcript)|ensembl:ENSMUST00000114224(transcript)|ensembl:ENSMUST00000114225(transcript)|ensembl:ENSMUST00000114226(transcript)|ensembl:ENSMUST00000114227(transcript)|ensembl:ENSMUST00000114228(transcript)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0042301"(phosphate ion binding)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR036284|reactome:R-MMU-1296041|reactome:R-MMU-202040|reactome:R-MMU-381676|reactome:R-MMU-392170|reactome:R-MMU-392451|reactome:R-MMU-392851|reactome:R-MMU-400042|reactome:R-MMU-4086398|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-418217|reactome:R-MMU-418555|reactome:R-MMU-418592|reactome:R-MMU-418594|reactome:R-MMU-418597|reactome:R-MMU-420092|reactome:R-MMU-428930|reactome:R-MMU-432040|reactome:R-MMU-456926|reactome:R-MMU-500657|reactome:R-MMU-6814122|reactome:R-MMU-8964315|reactome:R-MMU-8964616|reactome:R-MMU-9009391|reactome:R-MMU-997272|refseq:XP_006505605.1	psi-mi:"MI:0469"(intact)	-	-	delivery method:O88811 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:ruTJW3K1aXdRx2pccUmFMxPy6+E10090	rogid:29C/KggTANGedW9+lPzudGdahYk10090	intact-crc:CC6837E1B1B5D777|rigid:bGQtK/XAZa8H73OpoG17k7uopeU	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88811	uniprotkb:P05064	intact:EBI-2119154|uniprotkb:Q8C8Y4|uniprotkb:A2AU00|ensembl:ENSMUSP00000099820	intact:EBI-494220|ensembl:ENSMUSP00000032934|ensembl:ENSMUSP00000101955	psi-mi:stam2_mouse(display_long)|uniprotkb:Stam2(gene name)|psi-mi:Stam2(display_short)|uniprotkb:Hbp(gene name synonym)|uniprotkb:Hrs-binding protein(gene name synonym)	psi-mi:aldoa_mouse(display_long)|uniprotkb:Muscle-type aldolase(gene name synonym)|uniprotkb:Aldolase 1(gene name synonym)|uniprotkb:Aldoa(gene name)|psi-mi:Aldoa(display_short)|uniprotkb:Aldo1(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642981|imex:IM-8314-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062641.1|ensembl:ENSMUSG00000055371(gene)|ensembl:ENSMUST00000102759(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0015031"(protein transport)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001452(Src homology-3)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR035675|interpro:IPR036028|rcsb pdb:1UJ0|reactome:R-MMU-182971|reactome:R-MMU-5689880|reactome:R-MMU-6807004|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-9013420|reactome:R-MMU-917729	refseq:XP_006507273.1|refseq:XP_006507274.1|refseq:NP_001170779.1|refseq:NP_031464.1|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019242"(methylglyoxal biosynthetic process)|go:"GO:0030018"(Z disc)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0031430"(M band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0061615"(glycolytic process through fructose-6-phosphate)|go:"GO:0061827"(sperm head)|go:"GO:0005886"(plasma membrane)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|ensembl:ENSMUSG00000030695(gene)|ensembl:ENSMUST00000032934(transcript)|ensembl:ENSMUST00000106348(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0002020"(protease binding)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|mint:P05064|reactome:R-MMU-114608|reactome:R-MMU-6798695|reactome:R-MMU-70171|reactome:R-MMU-70263|interpro:IPR029768	psi-mi:"MI:0469"(intact)	-	-	delivery method:O88811 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:ruTJW3K1aXdRx2pccUmFMxPy6+E10090	rogid:m116/AX8vWkh1JCGOnEZv9ZOU9010090	intact-crc:CC6837E1B1B5D777|rigid:bGQtK/XAZa8H73OpoG17k7uopeU	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O88811	uniprotkb:Q64010	intact:EBI-2119154|uniprotkb:Q8C8Y4|uniprotkb:A2AU00|ensembl:ENSMUSP00000099820	intact:EBI-2906540|ensembl:ENSMUSP00000017920	psi-mi:stam2_mouse(display_long)|uniprotkb:Stam2(gene name)|psi-mi:Stam2(display_short)|uniprotkb:Hbp(gene name synonym)|uniprotkb:Hrs-binding protein(gene name synonym)	psi-mi:crk_mouse(display_long)|uniprotkb:Crk(gene name)|psi-mi:Crk(display_short)|uniprotkb:Crko(gene name synonym)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2642981|imex:IM-8314-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062641.1|ensembl:ENSMUSG00000055371(gene)|ensembl:ENSMUST00000102759(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0015031"(protein transport)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001452(Src homology-3)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR035675|interpro:IPR036028|rcsb pdb:1UJ0|reactome:R-MMU-182971|reactome:R-MMU-5689880|reactome:R-MMU-6807004|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-9013420|reactome:R-MMU-917729	refseq:NP_598417.2|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|ensembl:ENSMUSG00000017776(gene)|ensembl:ENSMUST00000017920(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901652"(response to peptide)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|rcsb pdb:1B07|rcsb pdb:1CKA|rcsb pdb:1CKB|rcsb pdb:1JU5|rcsb pdb:1M30|rcsb pdb:1M3A|rcsb pdb:1M3B|rcsb pdb:1M3C|rcsb pdb:2GGR|rcsb pdb:5IH2|rcsb pdb:5JN0|rcsb pdb:5L23|reactome:R-MMU-170984|reactome:R-MMU-186763|reactome:R-MMU-2029482|reactome:R-MMU-372708|reactome:R-MMU-4420097|reactome:R-MMU-8849471|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-912631|go:"GO:0035685"(helper T cell diapedesis)|dip:DIP-57059N	psi-mi:"MI:0469"(intact)	-	-	delivery method:O88811 infection|figure legend:Supplementary table 2, Fig 1 and 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:ruTJW3K1aXdRx2pccUmFMxPy6+E10090	rogid:e9eU7+wkCP5FNnenBlIixVbL7UM10090	intact-crc:CC6837E1B1B5D777|rigid:bGQtK/XAZa8H73OpoG17k7uopeU	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q38SD2	uniprotkb:P00519	intact:EBI-1050422|uniprotkb:Q6NVH5|uniprotkb:Q6NYC0|uniprotkb:Q6ZNL9|uniprotkb:Q6ZNM9|uniprotkb:Q96JN5|uniprotkb:Q9H5S3|ensembl:ENSP00000373600	intact:EBI-375543|uniprotkb:Q13869|uniprotkb:Q13870|uniprotkb:Q16133|uniprotkb:Q45F09|ensembl:ENSP00000323315|uniprotkb:A3KFJ3|uniprotkb:Q17R61|intact:EBI-1550796	psi-mi:lrrk1_human(display_long)|uniprotkb:LRRK1(gene name)|psi-mi:LRRK1(display_short)|uniprotkb:KIAA1790(gene name synonym)	psi-mi:abl1_human(display_long)|uniprotkb:Abelson tyrosine-protein kinase 1(gene name synonym)|uniprotkb:ABL1(gene name)|psi-mi:ABL1(display_short)|uniprotkb:ABL(gene name synonym)|uniprotkb:JTK7(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 1(gene name synonym)|uniprotkb:Proto-oncogene c-Abl(gene name synonym)|uniprotkb:p150(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2906661|imex:IM-8314-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078928.3|ensembl:ENSG00000154237(gene)|ensembl:ENST00000388948(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045453"(bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002110(Ankyrin)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020859|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|refseq:XP_011520314.1|refseq:XP_011520315.1|dip:DIP-50235N	refseq:NP_005148.2|refseq:NP_009297.2|ensembl:ENSG00000097007(gene)|ensembl:ENST00000318560(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016301"(kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019905"(syntaxin binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030035"(microspike assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002333"(transitional one stage B cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004515"(nicotinate-nucleotide adenylyltransferase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0038191"(neuropilin binding)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048668"(collateral sprouting)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071103"(DNA conformation change)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072359"(circulatory system development)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090135"(actin filament branching)|go:"GO:0098794"(postsynapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900275"(negative regulation of phospholipase C activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1903053"(regulation of extracellular matrix organization)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015015(F-actin binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR033221|interpro:IPR035837|interpro:IPR036028|interpro:IPR036860|mint:P00519|rcsb pdb:1AB2|rcsb pdb:1ABL|rcsb pdb:2HIW|rcsb pdb:2HYY|rcsb pdb:2HZ0|rcsb pdb:2HZ4|rcsb pdb:2HZI|rcsb pdb:2O88|rcsb pdb:2V7A|rcsb pdb:3CS9|rcsb pdb:3EG0|rcsb pdb:3EG1|rcsb pdb:3EG2|rcsb pdb:3EG3|rcsb pdb:3EGU|rcsb pdb:3K2M|rcsb pdb:3PYY|rcsb pdb:3QRI|rcsb pdb:3QRJ|rcsb pdb:3QRK|rcsb pdb:3T04|rcsb pdb:3UE4|rcsb pdb:3UYO|rcsb pdb:4J9B|rcsb pdb:4J9C|rcsb pdb:4J9D|rcsb pdb:1AWO|rcsb pdb:1BBZ|rcsb pdb:1JU5|rcsb pdb:1OPL|rcsb pdb:1ZZP|rcsb pdb:2ABL|rcsb pdb:2E2B|rcsb pdb:2F4J|rcsb pdb:2FO0|rcsb pdb:4J9E|rcsb pdb:2G1T|rcsb pdb:4J9F|rcsb pdb:2G2F|rcsb pdb:2G2H|rcsb pdb:4J9G|rcsb pdb:2G2I|rcsb pdb:4J9H|rcsb pdb:2GQG|rcsb pdb:4J9I|rcsb pdb:4JJB|rcsb pdb:4JJC|rcsb pdb:4JJD|rcsb pdb:4TWP|rcsb pdb:4WA9|rcsb pdb:4XEY|rcsb pdb:4YC8|rcsb pdb:4ZOG|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5HU9|rcsb pdb:5MO4|rcsb pdb:5NP2|rcsb pdb:5OAZ|rcsb pdb:6AMV|rcsb pdb:6AMW|rcsb pdb:6BL8|rcsb pdb:6NPE|rcsb pdb:6NPU|rcsb pdb:6NPV|rcsb pdb:6XR6|rcsb pdb:6XR7|rcsb pdb:6XRG|rcsb pdb:7CC2|rcsb pdb:7DT2|reactome:R-HSA-2029482|reactome:R-HSA-428890|reactome:R-HSA-525793|reactome:R-HSA-5663213|reactome:R-HSA-5685938|reactome:R-HSA-5693565|reactome:R-HSA-69231|reactome:R-HSA-8939236|reactome:R-HSA-8940973|reactome:R-HSA-9664422|reactome:R-HSA-983231|dip:DIP-1042N	psi-mi:"MI:0469"(intact)	-	-	delivery method:"Q38SD2 : infection"|figure legend:Supplementary table 10|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:mJ28kZNMsbiLTEZhR2Uw3u7s0iw9606	rogid:t7dT+fWrrK2QaWF4U0HQaVgHKUc9606	intact-crc:EEB071325AA5FD00|rigid:6qj+jCQHtTFP1c+54rJiemTUzwQ	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q38SD2	uniprotkb:Q60631	intact:EBI-1050422|uniprotkb:Q6NVH5|uniprotkb:Q6NYC0|uniprotkb:Q6ZNL9|uniprotkb:Q6ZNM9|uniprotkb:Q96JN5|uniprotkb:Q9H5S3|ensembl:ENSP00000373600	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:lrrk1_human(display_long)|uniprotkb:LRRK1(gene name)|psi-mi:LRRK1(display_short)|uniprotkb:KIAA1790(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2906661|imex:IM-8314-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078928.3|ensembl:ENSG00000154237(gene)|ensembl:ENST00000388948(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045453"(bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002110(Ankyrin)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020859|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|refseq:XP_011520314.1|refseq:XP_011520315.1|dip:DIP-50235N	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	psi-mi:"MI:0469"(intact)	-	-	delivery method:"Q38SD2 : infection"|figure legend:Supplementary table 10|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:mJ28kZNMsbiLTEZhR2Uw3u7s0iw9606	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:EEB071325AA5FD00|rigid:6qj+jCQHtTFP1c+54rJiemTUzwQ	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q38SD2	uniprotkb:P11274	intact:EBI-1050422|uniprotkb:Q6NVH5|uniprotkb:Q6NYC0|uniprotkb:Q6ZNL9|uniprotkb:Q6ZNM9|uniprotkb:Q96JN5|uniprotkb:Q9H5S3|ensembl:ENSP00000373600	intact:EBI-712838|intact:EBI-28971369|ensembl:ENSP00000303507|uniprotkb:P78501|uniprotkb:Q12842|uniprotkb:Q4LE80|uniprotkb:Q6NZI3	psi-mi:lrrk1_human(display_long)|uniprotkb:LRRK1(gene name)|psi-mi:LRRK1(display_short)|uniprotkb:KIAA1790(gene name synonym)	psi-mi:bcr_human(display_long)|uniprotkb:Renal carcinoma antigen NY-REN-26(gene name synonym)|uniprotkb:BCR(gene name)|psi-mi:BCR(display_short)|uniprotkb:BCR1(gene name synonym)|uniprotkb:D22S11(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2906661|imex:IM-8314-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078928.3|ensembl:ENSG00000154237(gene)|ensembl:ENST00000388948(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045453"(bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002110(Ankyrin)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020859|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|refseq:XP_011520314.1|refseq:XP_011520315.1|dip:DIP-50235N	ensembl:ENSG00000186716(gene)|ensembl:ENST00000305877(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030424"(axon)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0043197"(dendritic spine)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000198(RhoGAP)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR015123(Bcr-Abl oncoprotein oligomerisation)|interpro:IPR035892|interpro:IPR035899|interpro:IPR036481|interpro:IPR037769|rcsb pdb:1K1F|rcsb pdb:2AIN|rcsb pdb:5N6R|rcsb pdb:5N7E|rcsb pdb:5OC7|reactome:R-HSA-1839117|reactome:R-HSA-5655302|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|mint:P11274|ensembl:ENSP00000303507|ensembl:ENST00000359540|ensembl:ENSP00000352535|refseq:NP_004318.3|refseq:NP_067585.2	psi-mi:"MI:0469"(intact)	-	-	delivery method:"Q38SD2 : infection"|figure legend:Supplementary table 10|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:mJ28kZNMsbiLTEZhR2Uw3u7s0iw9606	rogid:U2+lPQ5c2dVW2MPLvknA0Bbg4fA9606	intact-crc:EEB071325AA5FD00|rigid:6qj+jCQHtTFP1c+54rJiemTUzwQ	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q38SD2	uniprotkb:P98083	intact:EBI-1050422|uniprotkb:Q6NVH5|uniprotkb:Q6NYC0|uniprotkb:Q6ZNL9|uniprotkb:Q6ZNM9|uniprotkb:Q96JN5|uniprotkb:Q9H5S3|ensembl:ENSP00000373600	intact:EBI-300201|ensembl:ENSMUSP00000091940|uniprotkb:Q3U2Q7|uniprotkb:Q8BFY3|uniprotkb:Q8K4C6|uniprotkb:Q8K4C7	psi-mi:lrrk1_human(display_long)|uniprotkb:LRRK1(gene name)|psi-mi:LRRK1(display_short)|uniprotkb:KIAA1790(gene name synonym)	psi-mi:shc1_mouse(display_long)|uniprotkb:ShcA(gene name synonym)|uniprotkb:Shc1(gene name)|psi-mi:Shc1(display_short)|uniprotkb:Shc(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2906661|imex:IM-8314-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078928.3|ensembl:ENSG00000154237(gene)|ensembl:ENST00000388948(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045453"(bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002110(Ankyrin)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020859|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|refseq:XP_011520314.1|refseq:XP_011520315.1|dip:DIP-50235N	ensembl:ENSMUST00000094378(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENSMUSG00000042626(gene)|go:"GO:0010008"(endosome membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|mint:P98083|reactome:R-MMU-1250196|reactome:R-MMU-1250347|reactome:R-MMU-167044|reactome:R-MMU-180336|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2428933|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1990839"(response to endothelin)|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354192|reactome:R-MMU-512988|reactome:R-MMU-5654688|reactome:R-MMU-5654699|reactome:R-MMU-5654704|reactome:R-MMU-5654719|reactome:R-MMU-5673001|reactome:R-MMU-74749|reactome:R-MMU-74751|interpro:IPR000980(SH2 motif)|reactome:R-MMU-8851805|reactome:R-MMU-8853659|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|reactome:R-MMU-8983432|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|reactome:R-MMU-9009391|reactome:R-MMU-9020558|reactome:R-MMU-9027284|reactome:R-MMU-9674555|reactome:R-MMU-912526|refseq:NP_001106802.1|refseq:NP_035498.2|dip:DIP-271N	psi-mi:"MI:0469"(intact)	-	-	delivery method:"Q38SD2 : infection"|figure legend:Supplementary table 10|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:mJ28kZNMsbiLTEZhR2Uw3u7s0iw9606	rogid:BksNa7XxzDyhK8y6ZdU5tz9CLUU10090	intact-crc:EEB071325AA5FD00|rigid:6qj+jCQHtTFP1c+54rJiemTUzwQ	false	tandem tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q38SD2	uniprotkb:B1AXY1	intact:EBI-1050422|uniprotkb:Q6NVH5|uniprotkb:Q6NYC0|uniprotkb:Q6ZNL9|uniprotkb:Q6ZNM9|uniprotkb:Q96JN5|uniprotkb:Q9H5S3|ensembl:ENSP00000373600	intact:EBI-2906679|ensembl:ENSMUSP00000118294	psi-mi:lrrk1_human(display_long)|uniprotkb:LRRK1(gene name)|psi-mi:LRRK1(display_short)|uniprotkb:KIAA1790(gene name synonym)	psi-mi:b1axy1_mouse(display_long)|uniprotkb:Dnaja1(gene name)|psi-mi:Dnaja1(display_short)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2906701|imex:IM-8314-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078928.3|ensembl:ENSG00000154237(gene)|ensembl:ENST00000388948(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045453"(bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002110(Ankyrin)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020859|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|refseq:XP_011520314.1|refseq:XP_011520315.1|dip:DIP-50235N	ensembl:ENSMUSG00000028410(gene)|ensembl:ENSMUST00000137246(transcript)|go:"GO:0006457"(protein folding)|go:"GO:0016020"(membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713	psi-mi:"MI:0469"(intact)	-	-	delivery method:"Q38SD2 : infection"|figure legend:Supplementary table 10|caution:Exact coordinates of Lrrk1 construct not given in the publication and have been inferred from the UniProtKB entry.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:mJ28kZNMsbiLTEZhR2Uw3u7s0iw9606	rogid:fO3NhcrKvygKQrUpMsZ9B/g+v7c10090	intact-crc:65A3373EDC1C7E49|rigid:F+OKY1O5IDycmP5AjUlySN0ztzw	false	tandem tag:?-?|sufficient binding region:595..595-1241..1241	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q38SD2	uniprotkb:P46935	intact:EBI-1050422|uniprotkb:Q6NVH5|uniprotkb:Q6NYC0|uniprotkb:Q6ZNL9|uniprotkb:Q6ZNM9|uniprotkb:Q96JN5|uniprotkb:Q9H5S3|ensembl:ENSP00000373600	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	psi-mi:lrrk1_human(display_long)|uniprotkb:LRRK1(gene name)|psi-mi:LRRK1(display_short)|uniprotkb:KIAA1790(gene name synonym)	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2906701|imex:IM-8314-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078928.3|ensembl:ENSG00000154237(gene)|ensembl:ENST00000388948(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045453"(bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002110(Ankyrin)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020859|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|refseq:XP_011520314.1|refseq:XP_011520315.1|dip:DIP-50235N	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	psi-mi:"MI:0469"(intact)	-	-	delivery method:"Q38SD2 : infection"|figure legend:Supplementary table 10|caution:Exact coordinates of Lrrk1 construct not given in the publication and have been inferred from the UniProtKB entry.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:mJ28kZNMsbiLTEZhR2Uw3u7s0iw9606	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	intact-crc:65A3373EDC1C7E49|rigid:F+OKY1O5IDycmP5AjUlySN0ztzw	false	tandem tag:?-?|sufficient binding region:595..595-1241..1241	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q38SD2	uniprotkb:P28656	intact:EBI-1050422|uniprotkb:Q6NVH5|uniprotkb:Q6NYC0|uniprotkb:Q6ZNL9|uniprotkb:Q6ZNM9|uniprotkb:Q96JN5|uniprotkb:Q9H5S3|ensembl:ENSP00000373600	intact:EBI-645055|uniprotkb:Q3UL14|ensembl:ENSMUSP00000070068|ensembl:ENSMUSP00000151750|ensembl:ENSMUSP00000151972	psi-mi:lrrk1_human(display_long)|uniprotkb:LRRK1(gene name)|psi-mi:LRRK1(display_short)|uniprotkb:KIAA1790(gene name synonym)	psi-mi:np1l1_mouse(display_long)|uniprotkb:NAP-1-related protein(gene name synonym)|uniprotkb:Brain protein DN38(gene name synonym)|uniprotkb:Nap1l1(gene name)|psi-mi:Nap1l1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2906701|imex:IM-8314-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078928.3|ensembl:ENSG00000154237(gene)|ensembl:ENST00000388948(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045453"(bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002110(Ankyrin)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020859|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|refseq:XP_011520314.1|refseq:XP_011520315.1|dip:DIP-50235N	refseq:NP_056596.1|ensembl:ENSMUSG00000058799(gene)|ensembl:ENSMUST00000065917(transcript)|ensembl:ENSMUST00000217908(transcript)|ensembl:ENSMUST00000218828(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019900"(kinase binding)|go:"GO:0042393"(histone binding)|go:"GO:0042470"(melanosome)|go:"GO:0043005"(neuron projection)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:P28656	psi-mi:"MI:0469"(intact)	-	-	delivery method:"Q38SD2 : infection"|figure legend:Supplementary table 10|caution:Exact coordinates of Lrrk1 construct not given in the publication and have been inferred from the UniProtKB entry.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:mJ28kZNMsbiLTEZhR2Uw3u7s0iw9606	rogid:AW+O1Tr5ZJ+2UVKVdK/5fqXesSs10090	intact-crc:65A3373EDC1C7E49|rigid:F+OKY1O5IDycmP5AjUlySN0ztzw	false	tandem tag:?-?|sufficient binding region:595..595-1241..1241	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q38SD2	uniprotkb:Q9WV55	intact:EBI-1050422|uniprotkb:Q6NVH5|uniprotkb:Q6NYC0|uniprotkb:Q6ZNL9|uniprotkb:Q6ZNM9|uniprotkb:Q96JN5|uniprotkb:Q9H5S3|ensembl:ENSP00000373600	intact:EBI-645974|uniprotkb:Q9QY77|uniprotkb:Q3TJM1|ensembl:ENSMUSP00000024897	psi-mi:lrrk1_human(display_long)|uniprotkb:LRRK1(gene name)|psi-mi:LRRK1(display_short)|uniprotkb:KIAA1790(gene name synonym)	psi-mi:vapa_mouse(display_long)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym)|uniprotkb:Vapa(gene name)|psi-mi:Vapa(display_short)|uniprotkb:Vap33(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2906701|imex:IM-8314-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078928.3|ensembl:ENSG00000154237(gene)|ensembl:ENST00000388948(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045453"(bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002110(Ankyrin)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020859|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|refseq:XP_011520314.1|refseq:XP_011520315.1|dip:DIP-50235N	refseq:NP_038961.2|ensembl:ENSMUSG00000024091(gene)|ensembl:ENSMUST00000024897(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9WV55|rcsb pdb:2CRI|reactome:R-MMU-1660661|reactome:R-MMU-6798695|reactome:R-MMU-9609523	psi-mi:"MI:0469"(intact)	-	-	delivery method:"Q38SD2 : infection"|figure legend:Supplementary table 10|caution:Exact coordinates of Lrrk1 construct not given in the publication and have been inferred from the UniProtKB entry.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:mJ28kZNMsbiLTEZhR2Uw3u7s0iw9606	rogid:LQV6uN7oD/EpHQvexl/pGkG6bmE10090	intact-crc:65A3373EDC1C7E49|rigid:F+OKY1O5IDycmP5AjUlySN0ztzw	false	tandem tag:?-?|sufficient binding region:595..595-1241..1241	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q38SD2	uniprotkb:Q64378	intact:EBI-1050422|uniprotkb:Q6NVH5|uniprotkb:Q6NYC0|uniprotkb:Q6ZNL9|uniprotkb:Q6ZNM9|uniprotkb:Q96JN5|uniprotkb:Q9H5S3|ensembl:ENSP00000373600	intact:EBI-492796|ensembl:ENSMUSP00000078382|ensembl:ENSMUSP00000110440|ensembl:ENSMUSP00000136245|ensembl:ENSMUSP00000156418	psi-mi:lrrk1_human(display_long)|uniprotkb:LRRK1(gene name)|psi-mi:LRRK1(display_short)|uniprotkb:KIAA1790(gene name synonym)	psi-mi:fkbp5_mouse(display_long)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:Fkbp5(gene name)|psi-mi:Fkbp5(display_short)|uniprotkb:Fkbp51(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2906742|imex:IM-8314-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078928.3|ensembl:ENSG00000154237(gene)|ensembl:ENST00000388948(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045453"(bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002110(Ankyrin)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020859|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|refseq:XP_011520314.1|refseq:XP_011520315.1|dip:DIP-50235N	refseq:NP_034350.1|ensembl:ENSMUSG00000024222(gene)|ensembl:ENSMUST00000079413(transcript)|ensembl:ENSMUST00000114792(transcript)|ensembl:ENSMUST00000177939(transcript)|ensembl:ENSMUST00000233102(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009617"(response to bacterium)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q64378|reactome:R-MMU-3371497|reactome:R-MMU-8939211	psi-mi:"MI:0469"(intact)	-	-	delivery method:"Q38SD2 : infection"|figure legend:Supplementary table 10|caution:Exact coordinates of Lrrk1 construct not given in the publication and have been inferred from the UniProtKB entry.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:mJ28kZNMsbiLTEZhR2Uw3u7s0iw9606	rogid:ihh8rfBDWGjo3gceXNl406Y50pU10090	intact-crc:67EDDCB9997D6D9B|rigid:NSxM8GmisDjmaWZPMM5R4YRj2pY	false	tandem tag:?-?|sufficient binding region:1242..1242-2015..2015	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q38SD2	uniprotkb:Q61081	intact:EBI-1050422|uniprotkb:Q6NVH5|uniprotkb:Q6NYC0|uniprotkb:Q6ZNL9|uniprotkb:Q6ZNM9|uniprotkb:Q96JN5|uniprotkb:Q9H5S3|ensembl:ENSP00000373600	intact:EBI-2906727|ensembl:ENSMUSP00000019615|uniprotkb:Q3TGP0	psi-mi:lrrk1_human(display_long)|uniprotkb:LRRK1(gene name)|psi-mi:LRRK1(display_short)|uniprotkb:KIAA1790(gene name synonym)	psi-mi:cdc37_mouse(display_long)|uniprotkb:Cdc37(gene name)|psi-mi:Cdc37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2906742|imex:IM-8314-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078928.3|ensembl:ENSG00000154237(gene)|ensembl:ENST00000388948(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045453"(bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002110(Ankyrin)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020859|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|refseq:XP_011520314.1|refseq:XP_011520315.1|dip:DIP-50235N	go:"GO:0032587"(ruffle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q61081|reactome:R-MMU-1227986|reactome:R-MMU-5675482|reactome:R-MMU-8863795|reactome:R-MMU-9013418|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|reactome:R-MMU-9652282|ensembl:ENSMUSG00000019471(gene)|ensembl:ENSMUST00000019615(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|refseq:NP_058022.1	psi-mi:"MI:0469"(intact)	-	-	delivery method:"Q38SD2 : infection"|figure legend:Supplementary table 10|caution:Exact coordinates of Lrrk1 construct not given in the publication and have been inferred from the UniProtKB entry.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:mJ28kZNMsbiLTEZhR2Uw3u7s0iw9606	rogid:v5zsOwSR7TCF51iF9RkxF1cPeaU10090	intact-crc:67EDDCB9997D6D9B|rigid:NSxM8GmisDjmaWZPMM5R4YRj2pY	false	tandem tag:?-?|sufficient binding region:1242..1242-2015..2015	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q38SD2	uniprotkb:Q9JJD8	intact:EBI-1050422|uniprotkb:Q6NVH5|uniprotkb:Q6NYC0|uniprotkb:Q6ZNL9|uniprotkb:Q6ZNM9|uniprotkb:Q96JN5|uniprotkb:Q9H5S3|ensembl:ENSP00000373600	intact:EBI-2906713	psi-mi:lrrk1_human(display_long)|uniprotkb:LRRK1(gene name)|psi-mi:LRRK1(display_short)|uniprotkb:KIAA1790(gene name synonym)	psi-mi:q9jjd8_mouse(display_long)|uniprotkb:Cct2(gene name)|psi-mi:Cct2(display_short)|uniprotkb:T-complex protein 1 subunit beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2906742|imex:IM-8314-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078928.3|ensembl:ENSG00000154237(gene)|ensembl:ENST00000388948(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045453"(bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002110(Ankyrin)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020859|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|refseq:XP_011520314.1|refseq:XP_011520315.1|dip:DIP-50235N	go:"GO:0005524"(ATP binding)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR012716(T-complex protein 1, beta subunit)|interpro:IPR017998|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027413	psi-mi:"MI:0469"(intact)	-	-	delivery method:"Q38SD2 : infection"|figure legend:Supplementary table 10|caution:Exact coordinates of Lrrk1 construct not given in the publication and have been inferred from the UniProtKB entry.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2014/10/16	rogid:mJ28kZNMsbiLTEZhR2Uw3u7s0iw9606	rogid:jKYzfEdeSvpwxiCl5PLalBuITBA10090	intact-crc:67EDDCB9997D6D9B|rigid:NSxM8GmisDjmaWZPMM5R4YRj2pY	false	tandem tag:?-?|sufficient binding region:1242..1242-2015..2015	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q38SD2	uniprotkb:P00519	intact:EBI-1050422|uniprotkb:Q6NVH5|uniprotkb:Q6NYC0|uniprotkb:Q6ZNL9|uniprotkb:Q6ZNM9|uniprotkb:Q96JN5|uniprotkb:Q9H5S3|ensembl:ENSP00000373600	intact:EBI-375543|uniprotkb:Q13869|uniprotkb:Q13870|uniprotkb:Q16133|uniprotkb:Q45F09|ensembl:ENSP00000323315|uniprotkb:A3KFJ3|uniprotkb:Q17R61|intact:EBI-1550796	psi-mi:lrrk1_human(display_long)|uniprotkb:LRRK1(gene name)|psi-mi:LRRK1(display_short)|uniprotkb:KIAA1790(gene name synonym)	psi-mi:abl1_human(display_long)|uniprotkb:Abelson tyrosine-protein kinase 1(gene name synonym)|uniprotkb:ABL1(gene name)|psi-mi:ABL1(display_short)|uniprotkb:ABL(gene name synonym)|uniprotkb:JTK7(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 1(gene name synonym)|uniprotkb:Proto-oncogene c-Abl(gene name synonym)|uniprotkb:p150(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2906837|imex:IM-8314-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078928.3|ensembl:ENSG00000154237(gene)|ensembl:ENST00000388948(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045453"(bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002110(Ankyrin)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020859|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|refseq:XP_011520314.1|refseq:XP_011520315.1|dip:DIP-50235N	refseq:NP_005148.2|refseq:NP_009297.2|ensembl:ENSG00000097007(gene)|ensembl:ENST00000318560(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016301"(kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019905"(syntaxin binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030035"(microspike assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002333"(transitional one stage B cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004515"(nicotinate-nucleotide adenylyltransferase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0038191"(neuropilin binding)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048668"(collateral sprouting)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071103"(DNA conformation change)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072359"(circulatory system development)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090135"(actin filament branching)|go:"GO:0098794"(postsynapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900275"(negative regulation of phospholipase C activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1903053"(regulation of extracellular matrix organization)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015015(F-actin binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR033221|interpro:IPR035837|interpro:IPR036028|interpro:IPR036860|mint:P00519|rcsb pdb:1AB2|rcsb pdb:1ABL|rcsb pdb:2HIW|rcsb pdb:2HYY|rcsb pdb:2HZ0|rcsb pdb:2HZ4|rcsb pdb:2HZI|rcsb pdb:2O88|rcsb pdb:2V7A|rcsb pdb:3CS9|rcsb pdb:3EG0|rcsb pdb:3EG1|rcsb pdb:3EG2|rcsb pdb:3EG3|rcsb pdb:3EGU|rcsb pdb:3K2M|rcsb pdb:3PYY|rcsb pdb:3QRI|rcsb pdb:3QRJ|rcsb pdb:3QRK|rcsb pdb:3T04|rcsb pdb:3UE4|rcsb pdb:3UYO|rcsb pdb:4J9B|rcsb pdb:4J9C|rcsb pdb:4J9D|rcsb pdb:1AWO|rcsb pdb:1BBZ|rcsb pdb:1JU5|rcsb pdb:1OPL|rcsb pdb:1ZZP|rcsb pdb:2ABL|rcsb pdb:2E2B|rcsb pdb:2F4J|rcsb pdb:2FO0|rcsb pdb:4J9E|rcsb pdb:2G1T|rcsb pdb:4J9F|rcsb pdb:2G2F|rcsb pdb:2G2H|rcsb pdb:4J9G|rcsb pdb:2G2I|rcsb pdb:4J9H|rcsb pdb:2GQG|rcsb pdb:4J9I|rcsb pdb:4JJB|rcsb pdb:4JJC|rcsb pdb:4JJD|rcsb pdb:4TWP|rcsb pdb:4WA9|rcsb pdb:4XEY|rcsb pdb:4YC8|rcsb pdb:4ZOG|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5HU9|rcsb pdb:5MO4|rcsb pdb:5NP2|rcsb pdb:5OAZ|rcsb pdb:6AMV|rcsb pdb:6AMW|rcsb pdb:6BL8|rcsb pdb:6NPE|rcsb pdb:6NPU|rcsb pdb:6NPV|rcsb pdb:6XR6|rcsb pdb:6XR7|rcsb pdb:6XRG|rcsb pdb:7CC2|rcsb pdb:7DT2|reactome:R-HSA-2029482|reactome:R-HSA-428890|reactome:R-HSA-525793|reactome:R-HSA-5663213|reactome:R-HSA-5685938|reactome:R-HSA-5693565|reactome:R-HSA-69231|reactome:R-HSA-8939236|reactome:R-HSA-8940973|reactome:R-HSA-9664422|reactome:R-HSA-983231|dip:DIP-1042N	psi-mi:"MI:0469"(intact)	-	-	delivery method:"Q38SD2 : infection"|figure legend:Supplementary table 10|caution:Exact coordinates of Lrrk1 construct not given in the publication and have been inferred from the UniProtKB entry.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2020/01/07	rogid:mJ28kZNMsbiLTEZhR2Uw3u7s0iw9606	rogid:t7dT+fWrrK2QaWF4U0HQaVgHKUc9606	intact-crc:BBFC3AD8B359F672|rigid:deYEm3ZT35YAIP8O4Lpj8kUoGh8	false	tandem tag:?-?|necessary binding region:1-617..617	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q38SD2	uniprotkb:P35235	intact:EBI-1050422|uniprotkb:Q6NVH5|uniprotkb:Q6NYC0|uniprotkb:Q6ZNL9|uniprotkb:Q6ZNM9|uniprotkb:Q96JN5|uniprotkb:Q9H5S3|ensembl:ENSP00000373600	intact:EBI-397236|uniprotkb:Q3TQ84|uniprotkb:Q64509|uniprotkb:Q6PCL5|ensembl:ENSMUSP00000098333	psi-mi:lrrk1_human(display_long)|uniprotkb:LRRK1(gene name)|psi-mi:LRRK1(display_short)|uniprotkb:KIAA1790(gene name synonym)	psi-mi:ptn11_mouse(display_long)|uniprotkb:Ptpn11(gene name)|psi-mi:Ptpn11(display_short)|uniprotkb:Protein-tyrosine phosphatase SYP(gene name synonym)|uniprotkb:SH-PTP2(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2906837|imex:IM-8314-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078928.3|ensembl:ENSG00000154237(gene)|ensembl:ENST00000388948(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045453"(bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002110(Ankyrin)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020859|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|refseq:XP_011520314.1|refseq:XP_011520315.1|dip:DIP-50235N	refseq:NP_001103462.1|refseq:NP_035332.1|go:"GO:0048609"(multicellular organismal reproductive process)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0048806"(genitalia development)|go:"GO:0048839"(inner ear development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051463"(negative regulation of cortisol secretion)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060325"(face morphogenesis)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0061582"(intestinal epithelial cell migration)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P35235|rcsb pdb:1AYA|rcsb pdb:1AYB|rcsb pdb:1AYC|rcsb pdb:1AYD|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|reactome:R-MMU-1059683|reactome:R-MMU-109704|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|reactome:R-MMU-110056|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|reactome:R-MMU-112411|reactome:R-MMU-114604|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|reactome:R-MMU-1257604|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-210990|reactome:R-MMU-210993|reactome:R-MMU-388841|reactome:R-MMU-389513|reactome:R-MMU-389948|reactome:R-MMU-432142|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-8854691|reactome:R-MMU-8865999|reactome:R-MMU-8934593|reactome:R-MMU-909733|reactome:R-MMU-912694|reactome:R-MMU-936964|reactome:R-MMU-9674555|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654700|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-6811558|reactome:R-MMU-8853659|ensembl:ENSMUSG00000043733(gene)|ensembl:ENSMUST00000100770(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030220"(platelet formation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032528"(microvillus organization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035265"(organ growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|dip:DIP-29669N	psi-mi:"MI:0469"(intact)	-	-	delivery method:"Q38SD2 : infection"|figure legend:Supplementary table 10|caution:Exact coordinates of Lrrk1 construct not given in the publication and have been inferred from the UniProtKB entry.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2020/01/07	rogid:mJ28kZNMsbiLTEZhR2Uw3u7s0iw9606	rogid:KL26Wt9vwG525fZ5SfvLc71Wsng10090	intact-crc:BBFC3AD8B359F672|rigid:deYEm3ZT35YAIP8O4Lpj8kUoGh8	false	tandem tag:?-?|necessary binding region:1-617..617	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q38SD2	uniprotkb:Q9QWY8	intact:EBI-1050422|uniprotkb:Q6NVH5|uniprotkb:Q6NYC0|uniprotkb:Q6ZNL9|uniprotkb:Q6ZNM9|uniprotkb:Q96JN5|uniprotkb:Q9H5S3|ensembl:ENSP00000373600	intact:EBI-698498|uniprotkb:Q99LV8|uniprotkb:Q9Z2B6|uniprotkb:O08612|uniprotkb:Q80TG8|uniprotkb:Q80UV6|uniprotkb:Q505F0|ensembl:ENSMUSP00000134825	psi-mi:lrrk1_human(display_long)|uniprotkb:LRRK1(gene name)|psi-mi:LRRK1(display_short)|uniprotkb:KIAA1790(gene name synonym)	psi-mi:asap1_mouse(display_long)|uniprotkb:PIP2-dependent ARF1 GAP(gene name synonym)|uniprotkb:ADP-ribosylation factor-directed GTPase-activating protein 1(gene name synonym)|uniprotkb:Development and differentiation-enhancing factor 1(gene name synonym)|uniprotkb:Asap1(gene name)|psi-mi:Asap1(display_short)|uniprotkb:Ddef1(gene name synonym)|uniprotkb:Kiaa1249(gene name synonym)|uniprotkb:Shag1(gene name synonym)|uniprotkb:130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2906837|imex:IM-8314-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078928.3|ensembl:ENSG00000154237(gene)|ensembl:ENST00000388948(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045453"(bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002110(Ankyrin)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020859|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|refseq:XP_011520314.1|refseq:XP_011520315.1|dip:DIP-50235N	refseq:NP_001263396.1|refseq:NP_034156.2|refseq:NP_001263390.1|refseq:NP_001263391.1|ensembl:ENSMUSG00000022377(gene)|ensembl:ENSMUST00000177374(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002102"(podosome)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0031253"(cell projection membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:1903527"(positive regulation of membrane tubulation)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027267|interpro:IPR036028|interpro:IPR036770|interpro:IPR037278|interpro:IPR037844|interpro:IPR037928|interpro:IPR038016|interpro:IPR038508|interpro:IPR043593|mint:Q9QWY8|rcsb pdb:5C6R|rcsb pdb:5C79|reactome:R-MMU-5620916	psi-mi:"MI:0469"(intact)	-	-	delivery method:"Q38SD2 : infection"|figure legend:Supplementary table 10|caution:Exact coordinates of Lrrk1 construct not given in the publication and have been inferred from the UniProtKB entry.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2020/01/07	rogid:mJ28kZNMsbiLTEZhR2Uw3u7s0iw9606	rogid:/jhMt+/t+DTqI3ZQmzU0IMFCHdA10090	intact-crc:BBFC3AD8B359F672|rigid:deYEm3ZT35YAIP8O4Lpj8kUoGh8	false	tandem tag:?-?|necessary binding region:1-617..617	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q38SD2	uniprotkb:P70218	intact:EBI-1050422|uniprotkb:Q6NVH5|uniprotkb:Q6NYC0|uniprotkb:Q6ZNL9|uniprotkb:Q6ZNM9|uniprotkb:Q96JN5|uniprotkb:Q9H5S3|ensembl:ENSP00000373600	intact:EBI-2906801|ensembl:ENSMUSP00000082995|uniprotkb:Q8R3R0|uniprotkb:Q99K62	psi-mi:lrrk1_human(display_long)|uniprotkb:LRRK1(gene name)|psi-mi:LRRK1(display_short)|uniprotkb:KIAA1790(gene name synonym)	psi-mi:m4k1_mouse(display_long)|uniprotkb:Map4k1(gene name)|psi-mi:Map4k1(display_short)|uniprotkb:Hpk1(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 1(gene name synonym)|uniprotkb:Hematopoietic progenitor kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2906837|imex:IM-8314-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078928.3|ensembl:ENSG00000154237(gene)|ensembl:ENST00000388948(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045453"(bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002110(Ankyrin)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020859|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|refseq:XP_011520314.1|refseq:XP_011520315.1|dip:DIP-50235N	ensembl:ENSMUSG00000037337(gene)|ensembl:ENSMUST00000085835(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|mint:P70218|rcsb pdb:1UTI|refseq:NP_032305.2|dip:DIP-42073N	psi-mi:"MI:0469"(intact)	-	-	delivery method:"Q38SD2 : infection"|figure legend:Supplementary table 10|caution:Exact coordinates of Lrrk1 construct not given in the publication and have been inferred from the UniProtKB entry.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2020/01/07	rogid:mJ28kZNMsbiLTEZhR2Uw3u7s0iw9606	rogid:15gWCuP+ntWBsa3l/ZP+qvsPwj410090	intact-crc:BBFC3AD8B359F672|rigid:deYEm3ZT35YAIP8O4Lpj8kUoGh8	false	tandem tag:?-?|necessary binding region:1-617..617	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q38SD2	uniprotkb:Q60631	intact:EBI-1050422|uniprotkb:Q6NVH5|uniprotkb:Q6NYC0|uniprotkb:Q6ZNL9|uniprotkb:Q6ZNM9|uniprotkb:Q96JN5|uniprotkb:Q9H5S3|ensembl:ENSP00000373600	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:lrrk1_human(display_long)|uniprotkb:LRRK1(gene name)|psi-mi:LRRK1(display_short)|uniprotkb:KIAA1790(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2906837|imex:IM-8314-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078928.3|ensembl:ENSG00000154237(gene)|ensembl:ENST00000388948(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045453"(bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002110(Ankyrin)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020859|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|refseq:XP_011520314.1|refseq:XP_011520315.1|dip:DIP-50235N	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	psi-mi:"MI:0469"(intact)	-	-	delivery method:"Q38SD2 : infection"|figure legend:Supplementary table 10|caution:Exact coordinates of Lrrk1 construct not given in the publication and have been inferred from the UniProtKB entry.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2020/01/07	rogid:mJ28kZNMsbiLTEZhR2Uw3u7s0iw9606	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:BBFC3AD8B359F672|rigid:deYEm3ZT35YAIP8O4Lpj8kUoGh8	false	tandem tag:?-?|necessary binding region:1-617..617	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q38SD2	uniprotkb:Q6P549	intact:EBI-1050422|uniprotkb:Q6NVH5|uniprotkb:Q6NYC0|uniprotkb:Q6ZNL9|uniprotkb:Q6ZNM9|uniprotkb:Q96JN5|uniprotkb:Q9H5S3|ensembl:ENSP00000373600	intact:EBI-2642932|uniprotkb:Q9JLL7|uniprotkb:Q80YB9|uniprotkb:O08611|uniprotkb:Q0VDX5|ensembl:ENSMUSP00000048057|ensembl:ENSMUSP00000132883	psi-mi:lrrk1_human(display_long)|uniprotkb:LRRK1(gene name)|psi-mi:LRRK1(display_short)|uniprotkb:KIAA1790(gene name synonym)	psi-mi:ship2_mouse(display_long)|uniprotkb:Inppl1(gene name)|psi-mi:Inppl1(display_short)|uniprotkb:Ship2(gene name synonym)|uniprotkb:Inositol polyphosphate phosphatase-like protein 1(gene name synonym)|uniprotkb:AblSH3-binding protein(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2906837|imex:IM-8314-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078928.3|ensembl:ENSG00000154237(gene)|ensembl:ENST00000388948(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045453"(bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002110(Ankyrin)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020859|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|refseq:XP_011520314.1|refseq:XP_011520315.1|dip:DIP-50235N	refseq:XP_011239984.1|refseq:NP_001116211.1|refseq:NP_034697.2|refseq:XP_006507454.1|ensembl:ENSMUSG00000032737(gene)|ensembl:ENSMUST00000035836(transcript)|ensembl:ENSMUST00000165052(transcript)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002376"(immune system process)|go:"GO:0003779"(actin binding)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0032868"(response to insulin)|go:"GO:0032957"(inositol trisphosphate metabolic process)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0097178"(ruffle assembly)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036691|interpro:IPR036860|mint:Q6P549|rcsb pdb:5ZRX|reactome:R-MMU-1660499|reactome:R-MMU-1855204|reactome:R-MMU-912526|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|refseq:XP_017177480.1	psi-mi:"MI:0469"(intact)	-	-	delivery method:"Q38SD2 : infection"|figure legend:Supplementary table 10|caution:Exact coordinates of Lrrk1 construct not given in the publication and have been inferred from the UniProtKB entry.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2020/01/07	rogid:mJ28kZNMsbiLTEZhR2Uw3u7s0iw9606	rogid:NwJCQILox6pZfYrGno128U2xdpQ10090	intact-crc:BBFC3AD8B359F672|rigid:deYEm3ZT35YAIP8O4Lpj8kUoGh8	false	tandem tag:?-?|necessary binding region:1-617..617	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q38SD2	uniprotkb:Q9ES52	intact:EBI-1050422|uniprotkb:Q6NVH5|uniprotkb:Q6NYC0|uniprotkb:Q6ZNL9|uniprotkb:Q6ZNM9|uniprotkb:Q96JN5|uniprotkb:Q9H5S3|ensembl:ENSP00000373600	intact:EBI-300210|ensembl:ENSMUSP00000127941|uniprotkb:Q3UPF9|uniprotkb:Q4U212|uniprotkb:Q61034|uniprotkb:Q61173|uniprotkb:Q61181|uniprotkb:Q9JKR7|uniprotkb:Q9JLF9|uniprotkb:Q9JLG0|uniprotkb:Q9QVN8|uniprotkb:Q9WUC2	psi-mi:lrrk1_human(display_long)|uniprotkb:LRRK1(gene name)|psi-mi:LRRK1(display_short)|uniprotkb:KIAA1790(gene name synonym)	psi-mi:ship1_mouse(display_long)|uniprotkb:Inpp5d(gene name)|psi-mi:Inpp5d(display_short)|uniprotkb:Ship(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase of 145 kDa(gene name synonym)|uniprotkb:p150Ship(gene name synonym)|uniprotkb:7a33(gene name synonym)|uniprotkb:Ship1(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase D(gene name synonym)|uniprotkb:Phosphatidylinositol-4,5-bisphosphate 5-phosphatase(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2906837|imex:IM-8314-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078928.3|ensembl:ENSG00000154237(gene)|ensembl:ENST00000388948(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045453"(bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002110(Ankyrin)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020859|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|refseq:XP_011520314.1|refseq:XP_011520315.1|dip:DIP-50235N	ensembl:ENSMUSG00000026288(gene)|ensembl:ENSMUST00000169754(transcript)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030487"(inositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045659"(negative regulation of neutrophil differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR036860|go:"GO:0050777"(negative regulation of immune response)|rcsb pdb:6DLG|reactome:R-MMU-1660499|reactome:R-MMU-1855204|reactome:R-MMU-202424|reactome:R-MMU-210990|reactome:R-MMU-912526|refseq:NP_001103662.1|refseq:NP_001103663.1|refseq:NP_034696.2	psi-mi:"MI:0469"(intact)	-	-	delivery method:"Q38SD2 : infection"|figure legend:Supplementary table 10|caution:Exact coordinates of Lrrk1 construct not given in the publication and have been inferred from the UniProtKB entry.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2020/01/07	rogid:mJ28kZNMsbiLTEZhR2Uw3u7s0iw9606	rogid:ipXHzUIAHLTMnjElS7ngcCqFuak10090	intact-crc:BBFC3AD8B359F672|rigid:deYEm3ZT35YAIP8O4Lpj8kUoGh8	false	tandem tag:?-?|necessary binding region:1-617..617	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q38SD2	uniprotkb:P61979	intact:EBI-1050422|uniprotkb:Q6NVH5|uniprotkb:Q6NYC0|uniprotkb:Q6ZNL9|uniprotkb:Q6ZNM9|uniprotkb:Q96JN5|uniprotkb:Q9H5S3|ensembl:ENSP00000373600	intact:EBI-299907|ensembl:ENSMUSP00000039269|uniprotkb:Q07244|uniprotkb:Q15671|uniprotkb:Q60577|uniprotkb:Q8BGQ8|uniprotkb:Q922Y7|uniprotkb:Q96J62	psi-mi:lrrk1_human(display_long)|uniprotkb:LRRK1(gene name)|psi-mi:LRRK1(display_short)|uniprotkb:KIAA1790(gene name synonym)	psi-mi:hnrpk_mouse(display_long)|uniprotkb:Hnrnpk(gene name)|psi-mi:Hnrnpk(display_short)|uniprotkb:Hnrpk(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2906837|imex:IM-8314-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078928.3|ensembl:ENSG00000154237(gene)|ensembl:ENST00000388948(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045453"(bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002110(Ankyrin)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020859|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|refseq:XP_011520314.1|refseq:XP_011520315.1|dip:DIP-50235N	ensembl:ENSMUST00000043269(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0002102"(podosome)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|ensembl:ENSMUSG00000021546(gene)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0030628"(pre-mRNA 3'-splice site binding)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|go:"GO:1990715"(mRNA CDS binding)|go:"GO:1990829"(C-rich single-stranded DNA binding)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000173"(negative regulation of branching morphogenesis of a nerve)|interpro:IPR004087(K Homology)|go:"GO:0051117"(ATPase binding)|go:"GO:0060999"(positive regulation of dendritic spine development)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012987(ROK, N-terminal)|interpro:IPR033090|interpro:IPR036612|mint:P61979|reactome:R-MMU-4570464|reactome:R-MMU-72163|reactome:R-MMU-72203|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1902165"(regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1904322"(cellular response to forskolin)|refseq:NP_001288269.1|refseq:NP_001288270.1|refseq:NP_001288272.1|refseq:NP_001288273.1|refseq:NP_001288274.1|refseq:XP_017170884.1|refseq:XP_017170885.1|refseq:NP_079555.1|refseq:XP_006517166.1|refseq:XP_006517167.1	psi-mi:"MI:0469"(intact)	-	-	delivery method:"Q38SD2 : infection"|figure legend:Supplementary table 10|caution:Exact coordinates of Lrrk1 construct not given in the publication and have been inferred from the UniProtKB entry.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2020/01/07	rogid:mJ28kZNMsbiLTEZhR2Uw3u7s0iw9606	rogid:YZQD5JJkHPUMtZ4XUA9fQkNfXzc10090	intact-crc:BBFC3AD8B359F672|rigid:deYEm3ZT35YAIP8O4Lpj8kUoGh8	false	tandem tag:?-?|necessary binding region:1-617..617	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q38SD2	uniprotkb:P98083	intact:EBI-1050422|uniprotkb:Q6NVH5|uniprotkb:Q6NYC0|uniprotkb:Q6ZNL9|uniprotkb:Q6ZNM9|uniprotkb:Q96JN5|uniprotkb:Q9H5S3|ensembl:ENSP00000373600	intact:EBI-300201|ensembl:ENSMUSP00000091940|uniprotkb:Q3U2Q7|uniprotkb:Q8BFY3|uniprotkb:Q8K4C6|uniprotkb:Q8K4C7	psi-mi:lrrk1_human(display_long)|uniprotkb:LRRK1(gene name)|psi-mi:LRRK1(display_short)|uniprotkb:KIAA1790(gene name synonym)	psi-mi:shc1_mouse(display_long)|uniprotkb:ShcA(gene name synonym)|uniprotkb:Shc1(gene name)|psi-mi:Shc1(display_short)|uniprotkb:Shc(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2906837|imex:IM-8314-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078928.3|ensembl:ENSG00000154237(gene)|ensembl:ENST00000388948(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045453"(bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002110(Ankyrin)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020859|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|refseq:XP_011520314.1|refseq:XP_011520315.1|dip:DIP-50235N	ensembl:ENSMUST00000094378(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENSMUSG00000042626(gene)|go:"GO:0010008"(endosome membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|mint:P98083|reactome:R-MMU-1250196|reactome:R-MMU-1250347|reactome:R-MMU-167044|reactome:R-MMU-180336|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2428933|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1990839"(response to endothelin)|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354192|reactome:R-MMU-512988|reactome:R-MMU-5654688|reactome:R-MMU-5654699|reactome:R-MMU-5654704|reactome:R-MMU-5654719|reactome:R-MMU-5673001|reactome:R-MMU-74749|reactome:R-MMU-74751|interpro:IPR000980(SH2 motif)|reactome:R-MMU-8851805|reactome:R-MMU-8853659|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|reactome:R-MMU-8983432|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|reactome:R-MMU-9009391|reactome:R-MMU-9020558|reactome:R-MMU-9027284|reactome:R-MMU-9674555|reactome:R-MMU-912526|refseq:NP_001106802.1|refseq:NP_035498.2|dip:DIP-271N	psi-mi:"MI:0469"(intact)	-	-	delivery method:"Q38SD2 : infection"|figure legend:Supplementary table 10|caution:Exact coordinates of Lrrk1 construct not given in the publication and have been inferred from the UniProtKB entry.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2020/01/07	rogid:mJ28kZNMsbiLTEZhR2Uw3u7s0iw9606	rogid:BksNa7XxzDyhK8y6ZdU5tz9CLUU10090	intact-crc:BBFC3AD8B359F672|rigid:deYEm3ZT35YAIP8O4Lpj8kUoGh8	false	tandem tag:?-?|necessary binding region:1-617..617	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q38SD2	uniprotkb:Q9Z1S8	intact:EBI-1050422|uniprotkb:Q6NVH5|uniprotkb:Q6NYC0|uniprotkb:Q6ZNL9|uniprotkb:Q6ZNM9|uniprotkb:Q96JN5|uniprotkb:Q9H5S3|ensembl:ENSP00000373600	intact:EBI-641738|uniprotkb:Q9R1X3	psi-mi:lrrk1_human(display_long)|uniprotkb:LRRK1(gene name)|psi-mi:LRRK1(display_short)|uniprotkb:KIAA1790(gene name synonym)	psi-mi:gab2_mouse(display_long)|uniprotkb:Growth factor receptor bound protein 2-associated protein 2(gene name synonym)|uniprotkb:GRB2-associated binder 2(gene name synonym)|uniprotkb:PH domain-containing adaptor molecule p97(gene name synonym)|uniprotkb:Gab2(gene name)|psi-mi:Gab2(display_short)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2906837|imex:IM-8314-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078928.3|ensembl:ENSG00000154237(gene)|ensembl:ENST00000388948(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045453"(bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002110(Ankyrin)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020859|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|refseq:XP_011520314.1|refseq:XP_011520315.1|dip:DIP-50235N	reactome:R-MMU-109704|reactome:R-MMU-1433557|reactome:R-MMU-2730905|reactome:R-MMU-8853659|reactome:R-MMU-912526|dip:DIP-41351N|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|reactome:R-MMU-9674555|reactome:R-MMU-1257604|reactome:R-MMU-6811558|reactome:R-MMU-9607240	psi-mi:"MI:0469"(intact)	-	-	delivery method:"Q38SD2 : infection"|figure legend:Supplementary table 10|caution:Exact coordinates of Lrrk1 construct not given in the publication and have been inferred from the UniProtKB entry.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2020/01/07	rogid:mJ28kZNMsbiLTEZhR2Uw3u7s0iw9606	rogid:DV50jtkpOksZpaqjllQRhmpYkvk10090	intact-crc:BBFC3AD8B359F672|rigid:deYEm3ZT35YAIP8O4Lpj8kUoGh8	false	tandem tag:?-?|necessary binding region:1-617..617	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q38SD2	uniprotkb:Q9QZK7	intact:EBI-1050422|uniprotkb:Q6NVH5|uniprotkb:Q6NYC0|uniprotkb:Q6ZNL9|uniprotkb:Q6ZNM9|uniprotkb:Q96JN5|uniprotkb:Q9H5S3|ensembl:ENSP00000373600	intact:EBI-2906753|ensembl:ENSMUSP00000046695|ensembl:ENSMUSP00000153308	psi-mi:lrrk1_human(display_long)|uniprotkb:LRRK1(gene name)|psi-mi:LRRK1(display_short)|uniprotkb:KIAA1790(gene name synonym)	psi-mi:dok3_mouse(display_long)|uniprotkb:Dok3(gene name)|psi-mi:Dok3(display_short)|uniprotkb:Dokl(gene name synonym)|uniprotkb:Downstream of tyrosine kinase 3(gene name synonym)|uniprotkb:"p62(dok)-like protein"(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2906837|imex:IM-8314-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078928.3|ensembl:ENSG00000154237(gene)|ensembl:ENST00000388948(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045453"(bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002110(Ankyrin)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020859|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|refseq:XP_011520314.1|refseq:XP_011520315.1|dip:DIP-50235N	ensembl:ENSMUSG00000035711(gene)|ensembl:ENSMUST00000047877(transcript)|ensembl:ENSMUST00000223563(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:Q9QZK7|reactome:R-MMU-6798695|refseq:NP_038767.1|refseq:XP_017171013.1	psi-mi:"MI:0469"(intact)	-	-	delivery method:"Q38SD2 : infection"|figure legend:Supplementary table 10|caution:Exact coordinates of Lrrk1 construct not given in the publication and have been inferred from the UniProtKB entry.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2020/01/07	rogid:mJ28kZNMsbiLTEZhR2Uw3u7s0iw9606	rogid:aCslT9wofEYOImuP4XNf2KK+rhk10090	intact-crc:BBFC3AD8B359F672|rigid:deYEm3ZT35YAIP8O4Lpj8kUoGh8	false	tandem tag:?-?|necessary binding region:1-617..617	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q38SD2	uniprotkb:Q62245	intact:EBI-1050422|uniprotkb:Q6NVH5|uniprotkb:Q6NYC0|uniprotkb:Q6ZNL9|uniprotkb:Q6ZNM9|uniprotkb:Q96JN5|uniprotkb:Q9H5S3|ensembl:ENSP00000373600	intact:EBI-1693|uniprotkb:Q62244|ensembl:ENSMUSP00000067786	psi-mi:lrrk1_human(display_long)|uniprotkb:LRRK1(gene name)|psi-mi:LRRK1(display_short)|uniprotkb:KIAA1790(gene name synonym)	psi-mi:sos1_mouse(display_long)|uniprotkb:Sos1(gene name)|psi-mi:Sos1(display_short)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2906837|imex:IM-8314-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078928.3|ensembl:ENSG00000154237(gene)|ensembl:ENST00000388948(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045453"(bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002110(Ankyrin)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020859|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|refseq:XP_011520314.1|refseq:XP_011520315.1|dip:DIP-50235N	refseq:NP_033257.2|dip:DIP-29230N|ensembl:ENSMUSG00000024241(gene)|ensembl:ENSMUST00000068714(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001942"(hair follicle development)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007296"(vitellogenesis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0033081"(regulation of T cell differentiation in thymus)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0060021"(roof of mouth development)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:1904693"(midbrain morphogenesis)|go:"GO:2000973"(regulation of pro-B cell differentiation)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR007125(Histone core)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR009072(Histone-fold)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR035899|interpro:IPR036964|mint:Q62245|rcsb pdb:1B07|rcsb pdb:1GBQ|rcsb pdb:1PMS|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180336|reactome:R-MMU-186763|reactome:R-MMU-193648|reactome:R-MMU-1963640|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-416482|reactome:R-MMU-5654688|reactome:R-MMU-5654693|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5673001|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8853659|reactome:R-MMU-8983432|reactome:R-MMU-9013149|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-9607240|reactome:R-MMU-983695	psi-mi:"MI:0469"(intact)	-	crc64:3286088A5BA0A4A6	delivery method:"Q38SD2 : infection"|figure legend:Supplementary table 10|caution:Exact coordinates of Lrrk1 construct not given in the publication and have been inferred from the UniProtKB entry.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2020/01/07	rogid:mJ28kZNMsbiLTEZhR2Uw3u7s0iw9606	rogid:n5Gaz6esU+5ryBPr8s91dizgMnE10090	intact-crc:BBFC3AD8B359F672|rigid:deYEm3ZT35YAIP8O4Lpj8kUoGh8	false	tandem tag:?-?|necessary binding region:1-617..617	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q38SD2	uniprotkb:Q02384	intact:EBI-1050422|uniprotkb:Q6NVH5|uniprotkb:Q6NYC0|uniprotkb:Q6ZNL9|uniprotkb:Q6ZNM9|uniprotkb:Q96JN5|uniprotkb:Q9H5S3|ensembl:ENSP00000373600	intact:EBI-395573|ensembl:ENSMUSP00000138793	psi-mi:lrrk1_human(display_long)|uniprotkb:LRRK1(gene name)|psi-mi:LRRK1(display_short)|uniprotkb:KIAA1790(gene name synonym)	psi-mi:sos2_mouse(display_long)|uniprotkb:Sos2(gene name)|psi-mi:Sos2(display_short)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2906837|imex:IM-8314-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078928.3|ensembl:ENSG00000154237(gene)|ensembl:ENST00000388948(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045453"(bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002110(Ankyrin)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020859|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|refseq:XP_011520314.1|refseq:XP_011520315.1|dip:DIP-50235N	ensembl:ENSMUSG00000034801(gene)|ensembl:ENSMUST00000183277(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0033081"(regulation of T cell differentiation in thymus)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:2000973"(regulation of pro-B cell differentiation)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR007125(Histone core)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR009072(Histone-fold)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR035899|interpro:IPR036964|rcsb pdb:1GBR|reactome:R-MMU-416482|reactome:R-MMU-193648|refseq:XP_006515698.1|reactome:R-MMU-8983432|reactome:R-MMU-9013149	psi-mi:"MI:0469"(intact)	-	-	delivery method:"Q38SD2 : infection"|figure legend:Supplementary table 10|caution:Exact coordinates of Lrrk1 construct not given in the publication and have been inferred from the UniProtKB entry.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2020/01/07	rogid:mJ28kZNMsbiLTEZhR2Uw3u7s0iw9606	rogid:s2OD+2IxmqGbJeKCshNho0MJczM10090	intact-crc:BBFC3AD8B359F672|rigid:deYEm3ZT35YAIP8O4Lpj8kUoGh8	false	tandem tag:?-?|necessary binding region:1-617..617	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q38SD2	uniprotkb:P11274	intact:EBI-1050422|uniprotkb:Q6NVH5|uniprotkb:Q6NYC0|uniprotkb:Q6ZNL9|uniprotkb:Q6ZNM9|uniprotkb:Q96JN5|uniprotkb:Q9H5S3|ensembl:ENSP00000373600	intact:EBI-712838|intact:EBI-28971369|ensembl:ENSP00000303507|uniprotkb:P78501|uniprotkb:Q12842|uniprotkb:Q4LE80|uniprotkb:Q6NZI3	psi-mi:lrrk1_human(display_long)|uniprotkb:LRRK1(gene name)|psi-mi:LRRK1(display_short)|uniprotkb:KIAA1790(gene name synonym)	psi-mi:bcr_human(display_long)|uniprotkb:Renal carcinoma antigen NY-REN-26(gene name synonym)|uniprotkb:BCR(gene name)|psi-mi:BCR(display_short)|uniprotkb:BCR1(gene name synonym)|uniprotkb:D22S11(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2906837|imex:IM-8314-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078928.3|ensembl:ENSG00000154237(gene)|ensembl:ENST00000388948(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045453"(bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002110(Ankyrin)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020859|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|refseq:XP_011520314.1|refseq:XP_011520315.1|dip:DIP-50235N	ensembl:ENSG00000186716(gene)|ensembl:ENST00000305877(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030424"(axon)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0043197"(dendritic spine)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000198(RhoGAP)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR015123(Bcr-Abl oncoprotein oligomerisation)|interpro:IPR035892|interpro:IPR035899|interpro:IPR036481|interpro:IPR037769|rcsb pdb:1K1F|rcsb pdb:2AIN|rcsb pdb:5N6R|rcsb pdb:5N7E|rcsb pdb:5OC7|reactome:R-HSA-1839117|reactome:R-HSA-5655302|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|mint:P11274|ensembl:ENSP00000303507|ensembl:ENST00000359540|ensembl:ENSP00000352535|refseq:NP_004318.3|refseq:NP_067585.2	psi-mi:"MI:0469"(intact)	-	-	delivery method:"Q38SD2 : infection"|figure legend:Supplementary table 10|caution:Exact coordinates of Lrrk1 construct not given in the publication and have been inferred from the UniProtKB entry.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2020/01/07	rogid:mJ28kZNMsbiLTEZhR2Uw3u7s0iw9606	rogid:U2+lPQ5c2dVW2MPLvknA0Bbg4fA9606	intact-crc:BBFC3AD8B359F672|rigid:deYEm3ZT35YAIP8O4Lpj8kUoGh8	false	tandem tag:?-?|necessary binding region:1-617..617	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q38SD2	uniprotkb:Q01730	intact:EBI-1050422|uniprotkb:Q6NVH5|uniprotkb:Q6NYC0|uniprotkb:Q6ZNL9|uniprotkb:Q6ZNM9|uniprotkb:Q96JN5|uniprotkb:Q9H5S3|ensembl:ENSP00000373600	intact:EBI-2906826	psi-mi:lrrk1_human(display_long)|uniprotkb:LRRK1(gene name)|psi-mi:LRRK1(display_short)|uniprotkb:KIAA1790(gene name synonym)	psi-mi:rsu1_mouse(display_long)|uniprotkb:Rsu1(gene name)|psi-mi:Rsu1(display_short)|uniprotkb:Rsp1(gene name synonym)	psi-mi:"MI:0096"(pull down)	B. et al. (2010)	imex:IM-8314|pubmed:20697350|mint:MINT-8010101	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2906837|imex:IM-8314-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078928.3|ensembl:ENSG00000154237(gene)|ensembl:ENST00000388948(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045453"(bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902533"(positive regulation of intracellular signal transduction)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002110(Ankyrin)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020859|interpro:IPR027417|interpro:IPR032171|interpro:IPR032675|interpro:IPR036322|interpro:IPR036770|refseq:XP_011520314.1|refseq:XP_011520315.1|dip:DIP-50235N	go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|reactome:R-MMU-446388|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|mint:Q01730	psi-mi:"MI:0469"(intact)	-	-	delivery method:"Q38SD2 : infection"|figure legend:Supplementary table 10|caution:Exact coordinates of Lrrk1 construct not given in the publication and have been inferred from the UniProtKB entry.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2010/04/16	2020/01/07	rogid:mJ28kZNMsbiLTEZhR2Uw3u7s0iw9606	rogid:nBkDHN46CHPx+UlaFIsFIwJw/2010090	intact-crc:BBFC3AD8B359F672|rigid:deYEm3ZT35YAIP8O4Lpj8kUoGh8	false	tandem tag:?-?|necessary binding region:1-617..617	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)