#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Y3C5	uniprotkb:Q9UJY5	intact:EBI-396669|intact:EBI-2129167|uniprotkb:A8KAI2|uniprotkb:Q5T7R8|ensembl:ENSP00000242719	intact:EBI-447141|uniprotkb:Q5TG07|uniprotkb:Q9BW94|uniprotkb:Q9UG00|uniprotkb:Q9UGW0|uniprotkb:Q9UGW1|uniprotkb:A8K3D3|uniprotkb:Q5R3N1|uniprotkb:Q6IC75|uniprotkb:B0QYR7|uniprotkb:Q86YA9|uniprotkb:Q8NCS6|ensembl:ENSP00000341344	psi-mi:rnf11_human(display_long)|uniprotkb:CGI-123(orf name)|uniprotkb:RNF11(gene name)|psi-mi:RNF11(display_short)	psi-mi:gga1_human(display_long)|uniprotkb:Golgi-localized, gamma ear-containing, ARF-binding protein 1(gene name synonym)|uniprotkb:Gamma-adaptin-related protein 1(gene name synonym)|uniprotkb:GGA1(gene name)|psi-mi:GGA1(display_short)	psi-mi:"MI:0047"(far western blotting)	Santonico et al. (2010)	pubmed:20676133|imex:IM-15180|mint:MINT-8012720	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1262"(I2D)	intact:EBI-2943688|imex:IM-15180-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055187.1|ensembl:ENSP00000242719|ensembl:ENSG00000123091(gene)|ensembl:ENST00000242719(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0055037"(recycling endosome)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042981|mint:Q9Y3C5	refseq:NP_001001560.1|refseq:NP_001166158.1|refseq:NP_001166159.1|refseq:NP_037497.1|refseq:XP_005261574.1|refseq:XP_011528424.1|refseq:XP_005261577.1|refseq:XP_006724292.1|refseq:XP_016884249.1|refseq:XP_016884250.1|refseq:XP_016884251.1|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR002014(VHS)|interpro:IPR004152(GAT)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR038425|interpro:IPR041198|mint:Q9UJY5|rcsb pdb:1J2J|rcsb pdb:1JWF|rcsb pdb:1JWG|rcsb pdb:1NA8|rcsb pdb:1NAF|rcsb pdb:1NWM|rcsb pdb:1O3X|rcsb pdb:1OM9|rcsb pdb:1OXZ|rcsb pdb:1PY1|rcsb pdb:1UJJ|rcsb pdb:1UJK|rcsb pdb:1X79|rcsb pdb:2DWX|rcsb pdb:2DWY|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3G2U|rcsb pdb:3G2V|rcsb pdb:3G2W|reactome:R-HSA-8854214|reactome:R-HSA-977225|ensembl:ENSG00000100083(gene)|ensembl:ENST00000343632(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008104"(protein localization)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043001"(Golgi to plasma membrane protein transport)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 9b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/11/09	2014/10/16	rogid:Uj0YAf/t+AdYbMd6fgQ8hVKoP0w9606	rogid:3n7Nia4JzMiDja0I7mUcyihFFBc9606	intact-crc:969CB04EF979C9B1|rigid:xO7aP71MLyT1X62WPEjjamXwOl0	false	sufficient binding region:7-21	glutathione s tranferase tag:?-?|sufficient binding region:17-147	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UJY5	uniprotkb:P11717	intact:EBI-447141|uniprotkb:Q5TG07|uniprotkb:Q9BW94|uniprotkb:Q9UG00|uniprotkb:Q9UGW0|uniprotkb:Q9UGW1|uniprotkb:A8K3D3|uniprotkb:Q5R3N1|uniprotkb:Q6IC75|uniprotkb:B0QYR7|uniprotkb:Q86YA9|uniprotkb:Q8NCS6|ensembl:ENSP00000341344	intact:EBI-1048580|uniprotkb:Q7Z7G9|uniprotkb:Q96PT5|ensembl:ENSP00000349437	psi-mi:gga1_human(display_long)|uniprotkb:Golgi-localized, gamma ear-containing, ARF-binding protein 1(gene name synonym)|uniprotkb:Gamma-adaptin-related protein 1(gene name synonym)|uniprotkb:GGA1(gene name)|psi-mi:GGA1(display_short)	psi-mi:mpri_human(display_long)|uniprotkb:Insulin-like growth factor 2 receptor(gene name synonym)|uniprotkb:Insulin-like growth factor II receptor(gene name synonym)|uniprotkb:M6P/IGF2 receptor(gene name synonym)|uniprotkb:300 kDa mannose 6-phosphate receptor(gene name synonym)|uniprotkb:IGF2R(gene name)|psi-mi:IGF2R(display_short)|uniprotkb:MPRI(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Santonico et al. (2010)	pubmed:20676133|imex:IM-15180|mint:MINT-8012720	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1262"(I2D)	intact:EBI-2943702|imex:IM-15180-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001001560.1|refseq:NP_001166158.1|refseq:NP_001166159.1|refseq:NP_037497.1|refseq:XP_005261574.1|refseq:XP_011528424.1|refseq:XP_005261577.1|refseq:XP_006724292.1|refseq:XP_016884249.1|refseq:XP_016884250.1|refseq:XP_016884251.1|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR002014(VHS)|interpro:IPR004152(GAT)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR038425|interpro:IPR041198|mint:Q9UJY5|rcsb pdb:1J2J|rcsb pdb:1JWF|rcsb pdb:1JWG|rcsb pdb:1NA8|rcsb pdb:1NAF|rcsb pdb:1NWM|rcsb pdb:1O3X|rcsb pdb:1OM9|rcsb pdb:1OXZ|rcsb pdb:1PY1|rcsb pdb:1UJJ|rcsb pdb:1UJK|rcsb pdb:1X79|rcsb pdb:2DWX|rcsb pdb:2DWY|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3G2U|rcsb pdb:3G2V|rcsb pdb:3G2W|reactome:R-HSA-8854214|reactome:R-HSA-977225|ensembl:ENSG00000100083(gene)|ensembl:ENST00000343632(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008104"(protein localization)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043001"(Golgi to plasma membrane protein transport)	refseq:NP_000867.2|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0005010"(insulin-like growth factor-activated receptor activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|ensembl:ENSG00000197081(gene)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000356956(transcript)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0001889"(liver development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1905394"(retromer complex binding)|interpro:IPR000479(Cation-independent mannose-6-phosphate receptor)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|interpro:IPR044865|mint:P11717|rcsb pdb:1E6F|rcsb pdb:1GP0|rcsb pdb:1GP3|rcsb pdb:1GQB|rcsb pdb:1JPL|rcsb pdb:1JWG|rcsb pdb:1LF8|rcsb pdb:2CNJ|rcsb pdb:2L29|rcsb pdb:2L2A|rcsb pdb:2M68|rcsb pdb:2M6T|rcsb pdb:2V5N|rcsb pdb:2V5O|rcsb pdb:2V5P|rcsb pdb:5IEI|rcsb pdb:6N5X|rcsb pdb:6N5Y|rcsb pdb:6P8I|rcsb pdb:6V02|rcsb pdb:6Z30|rcsb pdb:6Z31|rcsb pdb:6Z32|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|dip:DIP-6027N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 9b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/11/09	2014/10/16	rogid:3n7Nia4JzMiDja0I7mUcyihFFBc9606	rogid:7lkG6WR8MQ/SONiTV/8g1ZTtKTU9606	intact-crc:D89C8D3595838F39|rigid:VXenUlgo1NQzDq89s1U8t+MacL0	false	glutathione s tranferase tag:?-?|sufficient binding region:17-147	sufficient binding region:2477-2491|mutation decreasing interaction:2488-2489	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99523	uniprotkb:Q9UJY5	intact:EBI-1057058|uniprotkb:Q8IZ49|uniprotkb:C0JYZ0|uniprotkb:B4DWI3|ensembl:ENSP00000256637	intact:EBI-447141|uniprotkb:Q5TG07|uniprotkb:Q9BW94|uniprotkb:Q9UG00|uniprotkb:Q9UGW0|uniprotkb:Q9UGW1|uniprotkb:A8K3D3|uniprotkb:Q5R3N1|uniprotkb:Q6IC75|uniprotkb:B0QYR7|uniprotkb:Q86YA9|uniprotkb:Q8NCS6|ensembl:ENSP00000341344	psi-mi:sort_human(display_long)|uniprotkb:SORT1(gene name)|psi-mi:SORT1(display_short)|uniprotkb:Neurotensin receptor 3(gene name synonym)|uniprotkb:Glycoprotein 95(gene name synonym)|uniprotkb:100 kDa NT receptor(gene name synonym)	psi-mi:gga1_human(display_long)|uniprotkb:Golgi-localized, gamma ear-containing, ARF-binding protein 1(gene name synonym)|uniprotkb:Gamma-adaptin-related protein 1(gene name synonym)|uniprotkb:GGA1(gene name)|psi-mi:GGA1(display_short)	psi-mi:"MI:0047"(far western blotting)	Santonico et al. (2010)	pubmed:20676133|imex:IM-15180|mint:MINT-8012720	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1262"(I2D)	intact:EBI-2943714|imex:IM-15180-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001192157.1|refseq:NP_002950.3|ensembl:ENSG00000134243(gene)|ensembl:ENST00000256637(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0019899"(enzyme binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030379"(neurotensin receptor activity, non-G protein-coupled)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046323"(glucose import)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1905394"(retromer complex binding)|interpro:IPR006581(VPS10)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|mint:Q99523|rcsb pdb:3F6K|rcsb pdb:3G2U|rcsb pdb:3G2V|rcsb pdb:4MSL|rcsb pdb:4N7E|rcsb pdb:4PO7|rcsb pdb:5MRH|rcsb pdb:5MRI|rcsb pdb:6EHO|rcsb pdb:6X3L|rcsb pdb:6X48|rcsb pdb:6X4H|reactome:R-HSA-432722|go:"GO:0032868"(response to insulin)|dip:DIP-41798N	refseq:NP_001001560.1|refseq:NP_001166158.1|refseq:NP_001166159.1|refseq:NP_037497.1|refseq:XP_005261574.1|refseq:XP_011528424.1|refseq:XP_005261577.1|refseq:XP_006724292.1|refseq:XP_016884249.1|refseq:XP_016884250.1|refseq:XP_016884251.1|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR002014(VHS)|interpro:IPR004152(GAT)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR038425|interpro:IPR041198|mint:Q9UJY5|rcsb pdb:1J2J|rcsb pdb:1JWF|rcsb pdb:1JWG|rcsb pdb:1NA8|rcsb pdb:1NAF|rcsb pdb:1NWM|rcsb pdb:1O3X|rcsb pdb:1OM9|rcsb pdb:1OXZ|rcsb pdb:1PY1|rcsb pdb:1UJJ|rcsb pdb:1UJK|rcsb pdb:1X79|rcsb pdb:2DWX|rcsb pdb:2DWY|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3G2U|rcsb pdb:3G2V|rcsb pdb:3G2W|reactome:R-HSA-8854214|reactome:R-HSA-977225|ensembl:ENSG00000100083(gene)|ensembl:ENST00000343632(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008104"(protein localization)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043001"(Golgi to plasma membrane protein transport)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 9b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/11/09	2014/10/16	rogid:h/+2jen/dw+5leVis906F7iBs/A9606	rogid:3n7Nia4JzMiDja0I7mUcyihFFBc9606	intact-crc:F6945BFBBADE3189|rigid:IU92RvQtJSqIey7FB2bdmm/8e08	false	sufficient binding region:817-831|mutation decreasing interaction:829-830	glutathione s tranferase tag:?-?|sufficient binding region:17-147	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96J02	uniprotkb:Q9Y3C5	intact:EBI-1564678|uniprotkb:O43584|uniprotkb:Q5TEL0|uniprotkb:Q96F66|uniprotkb:Q9BY75|uniprotkb:Q9H451|uniprotkb:Q9H4U5|uniprotkb:A6NEW4|uniprotkb:Q5QP37|uniprotkb:E1P5P3|uniprotkb:B4E234|uniprotkb:F5H217|ensembl:ENSP00000262650|ensembl:ENSP00000499786	intact:EBI-396669|intact:EBI-2129167|uniprotkb:A8KAI2|uniprotkb:Q5T7R8|ensembl:ENSP00000242719	psi-mi:itch_human(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase Itchy homolog(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 4(gene name synonym)|uniprotkb:NFE2-associated polypeptide 1(gene name synonym)|uniprotkb:ITCH(gene name)|psi-mi:ITCH(display_short)	psi-mi:rnf11_human(display_long)|uniprotkb:CGI-123(orf name)|uniprotkb:RNF11(gene name)|psi-mi:RNF11(display_short)	psi-mi:"MI:0096"(pull down)	Santonico et al. (2010)	pubmed:20676133|imex:IM-15180|mint:MINT-8012720	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1262"(I2D)	intact:EBI-2943724|imex:IM-15180-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001311126.1|refseq:NP_113671.3|refseq:NP_001244066.1|refseq:NP_001311127.1|refseq:NP_001244067.1|refseq:XP_016883578.1|refseq:XP_016883580.1|dip:DIP-29849N|ensembl:ENSG00000078747(gene)|ensembl:ENST00000262650(transcript)|ensembl:ENST00000665346(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051607"(defense response to virus)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090085"(regulation of protein deubiquitination)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q96J02|rcsb pdb:2DMV|rcsb pdb:2KYK|rcsb pdb:2NQ3|rcsb pdb:2P4R|rcsb pdb:2YSF|rcsb pdb:3TUG|rcsb pdb:4ROF|rcsb pdb:5C7M|rcsb pdb:5CQ2|rcsb pdb:5DWS|rcsb pdb:5DZD|rcsb pdb:5SXP|reactome:R-HSA-1253288|reactome:R-HSA-168638|reactome:R-HSA-2122948|reactome:R-HSA-5610780|reactome:R-HSA-5632684|reactome:R-HSA-8939236|reactome:R-HSA-936440|reactome:R-HSA-983168	refseq:NP_055187.1|ensembl:ENSP00000242719|ensembl:ENSG00000123091(gene)|ensembl:ENST00000242719(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0055037"(recycling endosome)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042981|mint:Q9Y3C5	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 10|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/11/09	2014/10/16	rogid:JyySOfI+ZHOI1mvdxWDGN6njgCY9606	rogid:Uj0YAf/t+AdYbMd6fgQ8hVKoP0w9606	intact-crc:D72EB7708D4FCD17|rigid:KGkmEtBiVoRUjYvLeG1DVinbj2U	false	sufficient binding region:438-471(IPR001202)|glutathione s tranferase tag:?-?	mutation disrupting interaction:40-40|green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P46934	uniprotkb:Q9Y3C5	intact:EBI-726944|ensembl:ENSP00000424827|uniprotkb:A1KY35|uniprotkb:A6ND72|uniprotkb:A7MD29|uniprotkb:B4E2R7|uniprotkb:B7ZM59|uniprotkb:B7ZM60|uniprotkb:B9EGN5|uniprotkb:D6RF89|intact:EBI-28969445	intact:EBI-396669|intact:EBI-2129167|uniprotkb:A8KAI2|uniprotkb:Q5T7R8|ensembl:ENSP00000242719	psi-mi:nedd4_human(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:NEDD4(gene name)|psi-mi:NEDD4(display_short)|uniprotkb:KIAA0093(gene name synonym)|uniprotkb:NEDD4-1(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 53 protein(gene name synonym)|uniprotkb:PIG53(orf name)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)	psi-mi:rnf11_human(display_long)|uniprotkb:CGI-123(orf name)|uniprotkb:RNF11(gene name)|psi-mi:RNF11(display_short)	psi-mi:"MI:0096"(pull down)	Santonico et al. (2010)	pubmed:20676133|imex:IM-15180|mint:MINT-8012720	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1262"(I2D)	intact:EBI-2943749|imex:IM-15180-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001271267.1|refseq:NP_001271268.1|refseq:NP_001271269.1|ensembl:ENSG00000069869(gene)|ensembl:ENST00000508342(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0010768"(negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043197"(dendritic spine)|go:"GO:0044111"(formation of structure involved in a symbiotic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046755"(viral budding)|go:"GO:0046824"(positive regulation of nucleocytoplasmic transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051592"(response to calcium ion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46934|rcsb pdb:2KPZ|rcsb pdb:2KQ0|go:"GO:0050815"(phosphoserine residue binding)|rcsb pdb:2M3O|rcsb pdb:2XBB|rcsb pdb:2XBF|rcsb pdb:3B7Y|rcsb pdb:4BBN|rcsb pdb:4BE8|rcsb pdb:4N7F|rcsb pdb:4N7H|rcsb pdb:5AHT|rcsb pdb:5C7J|rcsb pdb:5C91|reactome:R-HSA-1169408|reactome:R-HSA-1253288|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-983168|refseq:NP_006145.2|refseq:NP_940682.2|ensembl:ENST00000338963|ensembl:ENSP00000345530|ensembl:ENST00000435532|ensembl:ENSP00000410613|ensembl:ENST00000506154|ensembl:ENSP00000422705|ensembl:ENSP00000424827|refseq:NP_001316141.1|dip:DIP-29815N	refseq:NP_055187.1|ensembl:ENSP00000242719|ensembl:ENSG00000123091(gene)|ensembl:ENST00000242719(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0055037"(recycling endosome)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042981|mint:Q9Y3C5	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 10|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/11/09	2014/10/16	rogid:R0IvurHHFLE8EYZK1hRLsSwbs5I9606	rogid:Uj0YAf/t+AdYbMd6fgQ8hVKoP0w9606	intact-crc:352D8A16251B5EAC|rigid:IsxhfI5OfxmYqVcv+8YQNYGh8SM	false	sufficient binding region:840-873(IPR001202)|glutathione s tranferase tag:?-?	mutation disrupting interaction:40-40|green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9HAU4	uniprotkb:Q9Y3C5	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	intact:EBI-396669|intact:EBI-2129167|uniprotkb:A8KAI2|uniprotkb:Q5T7R8|ensembl:ENSP00000242719	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:rnf11_human(display_long)|uniprotkb:CGI-123(orf name)|uniprotkb:RNF11(gene name)|psi-mi:RNF11(display_short)	psi-mi:"MI:0096"(pull down)	Santonico et al. (2010)	pubmed:20676133|imex:IM-15180|mint:MINT-8012720	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1262"(I2D)	intact:EBI-2943783|imex:IM-15180-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N	refseq:NP_055187.1|ensembl:ENSP00000242719|ensembl:ENSG00000123091(gene)|ensembl:ENST00000242719(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0055037"(recycling endosome)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042981|mint:Q9Y3C5	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 10|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/11/09	2014/10/16	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	rogid:Uj0YAf/t+AdYbMd6fgQ8hVKoP0w9606	intact-crc:0629CFA5ECAC3CD4|rigid:y6QTV+14NMNj9D8tnc4+hcaBPR0	false	sufficient binding region:297-330(IPR001202)	green fluorescent protein tag:?-?|mutation disrupting interaction:40-40	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y3C5	uniprotkb:Q96J02	intact:EBI-396669|intact:EBI-2129167|uniprotkb:A8KAI2|uniprotkb:Q5T7R8|ensembl:ENSP00000242719	intact:EBI-1564678|uniprotkb:O43584|uniprotkb:Q5TEL0|uniprotkb:Q96F66|uniprotkb:Q9BY75|uniprotkb:Q9H451|uniprotkb:Q9H4U5|uniprotkb:A6NEW4|uniprotkb:Q5QP37|uniprotkb:E1P5P3|uniprotkb:B4E234|uniprotkb:F5H217|ensembl:ENSP00000262650|ensembl:ENSP00000499786	psi-mi:rnf11_human(display_long)|uniprotkb:CGI-123(orf name)|uniprotkb:RNF11(gene name)|psi-mi:RNF11(display_short)	psi-mi:itch_human(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase Itchy homolog(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 4(gene name synonym)|uniprotkb:NFE2-associated polypeptide 1(gene name synonym)|uniprotkb:ITCH(gene name)|psi-mi:ITCH(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Santonico et al. (2010)	pubmed:20676133|imex:IM-15180|mint:MINT-8012720	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-2944340|imex:IM-15180-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055187.1|ensembl:ENSP00000242719|ensembl:ENSG00000123091(gene)|ensembl:ENST00000242719(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0055037"(recycling endosome)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042981|mint:Q9Y3C5	refseq:NP_001311126.1|refseq:NP_113671.3|refseq:NP_001244066.1|refseq:NP_001311127.1|refseq:NP_001244067.1|refseq:XP_016883578.1|refseq:XP_016883580.1|dip:DIP-29849N|ensembl:ENSG00000078747(gene)|ensembl:ENST00000262650(transcript)|ensembl:ENST00000665346(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051607"(defense response to virus)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090085"(regulation of protein deubiquitination)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q96J02|rcsb pdb:2DMV|rcsb pdb:2KYK|rcsb pdb:2NQ3|rcsb pdb:2P4R|rcsb pdb:2YSF|rcsb pdb:3TUG|rcsb pdb:4ROF|rcsb pdb:5C7M|rcsb pdb:5CQ2|rcsb pdb:5DWS|rcsb pdb:5DZD|rcsb pdb:5SXP|reactome:R-HSA-1253288|reactome:R-HSA-168638|reactome:R-HSA-2122948|reactome:R-HSA-5610780|reactome:R-HSA-5632684|reactome:R-HSA-8939236|reactome:R-HSA-936440|reactome:R-HSA-983168	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 13|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/11/09	2014/10/16	rogid:Uj0YAf/t+AdYbMd6fgQ8hVKoP0w9606	rogid:JyySOfI+ZHOI1mvdxWDGN6njgCY9606	intact-crc:1C2BCFCB6097610F|rigid:KGkmEtBiVoRUjYvLeG1DVinbj2U	false	mutation disrupting interaction:40-40|flag tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9UJY5	uniprotkb:Q9Y3C5	intact:EBI-447141|uniprotkb:Q5TG07|uniprotkb:Q9BW94|uniprotkb:Q9UG00|uniprotkb:Q9UGW0|uniprotkb:Q9UGW1|uniprotkb:A8K3D3|uniprotkb:Q5R3N1|uniprotkb:Q6IC75|uniprotkb:B0QYR7|uniprotkb:Q86YA9|uniprotkb:Q8NCS6|ensembl:ENSP00000341344	intact:EBI-396669|intact:EBI-2129167|uniprotkb:A8KAI2|uniprotkb:Q5T7R8|ensembl:ENSP00000242719	psi-mi:gga1_human(display_long)|uniprotkb:Golgi-localized, gamma ear-containing, ARF-binding protein 1(gene name synonym)|uniprotkb:Gamma-adaptin-related protein 1(gene name synonym)|uniprotkb:GGA1(gene name)|psi-mi:GGA1(display_short)	psi-mi:rnf11_human(display_long)|uniprotkb:CGI-123(orf name)|uniprotkb:RNF11(gene name)|psi-mi:RNF11(display_short)	psi-mi:"MI:0096"(pull down)	Santonico et al. (2010)	pubmed:20676133|imex:IM-15180|mint:MINT-8012720	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1262"(I2D)	intact:EBI-2943678|imex:IM-15180-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001001560.1|refseq:NP_001166158.1|refseq:NP_001166159.1|refseq:NP_037497.1|refseq:XP_005261574.1|refseq:XP_011528424.1|refseq:XP_005261577.1|refseq:XP_006724292.1|refseq:XP_016884249.1|refseq:XP_016884250.1|refseq:XP_016884251.1|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR002014(VHS)|interpro:IPR004152(GAT)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR038425|interpro:IPR041198|mint:Q9UJY5|rcsb pdb:1J2J|rcsb pdb:1JWF|rcsb pdb:1JWG|rcsb pdb:1NA8|rcsb pdb:1NAF|rcsb pdb:1NWM|rcsb pdb:1O3X|rcsb pdb:1OM9|rcsb pdb:1OXZ|rcsb pdb:1PY1|rcsb pdb:1UJJ|rcsb pdb:1UJK|rcsb pdb:1X79|rcsb pdb:2DWX|rcsb pdb:2DWY|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3G2U|rcsb pdb:3G2V|rcsb pdb:3G2W|reactome:R-HSA-8854214|reactome:R-HSA-977225|ensembl:ENSG00000100083(gene)|ensembl:ENST00000343632(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008104"(protein localization)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043001"(Golgi to plasma membrane protein transport)	refseq:NP_055187.1|ensembl:ENSP00000242719|ensembl:ENSG00000123091(gene)|ensembl:ENST00000242719(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0055037"(recycling endosome)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042981|mint:Q9Y3C5	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 9a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/11/09	2014/10/16	rogid:3n7Nia4JzMiDja0I7mUcyihFFBc9606	rogid:Uj0YAf/t+AdYbMd6fgQ8hVKoP0w9606	intact-crc:90C4D59DA5AAD49F|rigid:xO7aP71MLyT1X62WPEjjamXwOl0	false	-	glutathione s tranferase tag:?-?|sufficient binding region:1-100	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)