#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q08499-2	uniprotkb:P17612	intact:EBI-8095525|intact:MINT-92306|ensembl:ENSP00000353152	intact:EBI-476586|uniprotkb:Q32P54|uniprotkb:Q9H2Y0|uniprotkb:Q9NRB4|uniprotkb:Q9NRH9|ensembl:ENSP00000309591|ensembl:ENSP00000499940	psi-mi:q08499-2(display_long)|uniprotkb:PDE4D(gene name)|psi-mi:PDE4D(display_short)|uniprotkb:DPDE3(gene name synonym)|uniprotkb:PDE43(gene name synonym)|uniprotkb:hPDE4D3(isoform synonym)	psi-mi:kapca_human(display_long)|uniprotkb:PRKACA(gene name)|psi-mi:PRKACA(display_short)|uniprotkb:PKACA(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Halls et al. (2010)	pubmed:20664520|imex:IM-15121|mint:MINT-8041780|doi:10.1038/emboj.2010.168	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8095518|mint:MINT-8041863|imex:IM-15121-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1642831(isoform-parent)|ensembl:ENSG00000113448(gene)|ensembl:ENST00000360047(transcript)|mint:MINT-8041877(identity)	refseq:NP_002721.1|refseq:NP_997401.1|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|ensembl:ENSG00000072062(gene)|ensembl:ENSG00000288516(gene)|ensembl:ENST00000308677(transcript)|ensembl:ENST00000673550(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001843"(neural tube closure)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0036126"(sperm flagellum)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0048240"(sperm capacitation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070613"(regulation of protein processing)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097546"(ciliary base)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|go:"GO:0046827"(positive regulation of protein export from nucleus)|rcsb pdb:5IZJ|rcsb pdb:5J5X|rcsb pdb:5N23|rcsb pdb:5UZK|rcsb pdb:6BYR|rcsb pdb:6BYS|rcsb pdb:6C0U|rcsb pdb:6FRX|rcsb pdb:6NO7|rcsb pdb:6QJ7|rcsb pdb:6WJF|rcsb pdb:6WJG|reactome:R-HSA-111931|reactome:R-HSA-163358|reactome:R-HSA-163560|reactome:R-HSA-163615|reactome:R-HSA-164378|reactome:R-HSA-180024|reactome:R-HSA-2565942|reactome:R-HSA-380259|rcsb pdb:3MVJ|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:3NX8|interpro:IPR044109|rcsb pdb:3OOG|rcsb pdb:3OVV|rcsb pdb:3OWP|rcsb pdb:3OXT|rcsb pdb:3P0M|mint:P17612|rcsb pdb:3POO|rcsb pdb:3VQH|rcsb pdb:4AE6|rcsb pdb:2GU8|rcsb pdb:4AE9|rcsb pdb:4UJ1|rcsb pdb:4UJ2|rcsb pdb:3AGL|rcsb pdb:3AGM|rcsb pdb:3AMA|rcsb pdb:3AMB|rcsb pdb:4UJ9|rcsb pdb:4UJA|rcsb pdb:4UJB|rcsb pdb:4WB5|rcsb pdb:4WB6|rcsb pdb:4WB7|rcsb pdb:3L9L|rcsb pdb:3L9M|rcsb pdb:3L9N|rcsb pdb:4WB8|rcsb pdb:5BX6|rcsb pdb:5BX7|rcsb pdb:5IZF|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-381676|reactome:R-HSA-392517|reactome:R-HSA-422356|reactome:R-HSA-432040|reactome:R-HSA-4420097|reactome:R-HSA-442720|reactome:R-HSA-512988|reactome:R-HSA-5578775|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5610787|reactome:R-HSA-5620912|reactome:R-HSA-5621575|reactome:R-HSA-5687128|reactome:R-HSA-8853659|reactome:R-HSA-8854518|reactome:R-HSA-380320|reactome:R-HSA-8963896|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9634600|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-983231|reactome:R-HSA-9010642|refseq:NP_001291278.1|dip:DIP-33878N|mint:MINT-8041879(identity)	-	isoform-comment:Contains a phosphoserine at position 54. Activated by phosphorylation at Ser-53. Mutagenesis of Ser-54 abolishes activation.|comment:mint	-	figure legend:f7a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/10/04	2014/10/16	rogid:SCJsnMndW2xYbXz1n1TPl76wwis9606	rogid:7yhAi67qjSKPIff2dwqjScPXEYM9606	intact-crc:B1030EE980AAD38A|rigid:Q7h4IJCsvKFNSMx/147qdZY0W+k	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q08499-2	uniprotkb:Q9HBX9	intact:EBI-8095525|intact:MINT-92306|ensembl:ENSP00000353152	intact:EBI-8088969|uniprotkb:Q3KU24|uniprotkb:Q3KU25|uniprotkb:Q3KU26|uniprotkb:Q2M215|intact:MINT-231156|uniprotkb:B4DTV2|uniprotkb:B4DHD1|ensembl:ENSP00000303248	psi-mi:q08499-2(display_long)|uniprotkb:PDE4D(gene name)|psi-mi:PDE4D(display_short)|uniprotkb:DPDE3(gene name synonym)|uniprotkb:PDE43(gene name synonym)|uniprotkb:hPDE4D3(isoform synonym)	psi-mi:rxfp1_human(display_long)|uniprotkb:RXFP1(gene name)|psi-mi:RXFP1(display_short)|uniprotkb:LGR7(gene name synonym)|uniprotkb:Relaxin family peptide receptor 1(gene name synonym)|uniprotkb:Leucine-rich repeat-containing G-protein coupled receptor 7(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Halls et al. (2010)	pubmed:20664520|imex:IM-15121|mint:MINT-8041780|doi:10.1038/emboj.2010.168	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8095518|mint:MINT-8041863|imex:IM-15121-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1642831(isoform-parent)|ensembl:ENSG00000113448(gene)|ensembl:ENST00000360047(transcript)|mint:MINT-8041877(identity)	refseq:NP_067647.2|refseq:NP_001240657.1|refseq:NP_001240658.1|ensembl:ENSG00000171509(gene)|ensembl:ENST00000307765(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007567"(parturition)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0042562"(hormone binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060427"(lung connective tissue development)|go:"GO:0060658"(nipple morphogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR008112(Relaxin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR023415|interpro:IPR032675|interpro:IPR036055|rcsb pdb:2JM4|rcsb pdb:2M7P|reactome:R-HSA-418555|reactome:R-HSA-444821|reactome:R-HSA-9660821|mint:MINT-8041871(identity)	-	isoform-comment:Contains a phosphoserine at position 54. Activated by phosphorylation at Ser-53. Mutagenesis of Ser-54 abolishes activation.|comment:mint	function:Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP|comment:mint	figure legend:f7a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/10/04	2014/10/16	rogid:SCJsnMndW2xYbXz1n1TPl76wwis9606	rogid:8flEswbzhb+rQGfn16DgFOLTJlg9606	intact-crc:B1030EE980AAD38A|rigid:Q7h4IJCsvKFNSMx/147qdZY0W+k	false	-	flag tag:?-?(MINT-8041872)|mutation disrupting interaction:704-704(MINT-8041887)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q08499-2	uniprotkb:P26769	intact:EBI-8095525|intact:MINT-92306|ensembl:ENSP00000353152	intact:EBI-1027877	psi-mi:q08499-2(display_long)|uniprotkb:PDE4D(gene name)|psi-mi:PDE4D(display_short)|uniprotkb:DPDE3(gene name synonym)|uniprotkb:PDE43(gene name synonym)|uniprotkb:hPDE4D3(isoform synonym)	psi-mi:adcy2_rat(display_long)|uniprotkb:Adcy2(gene name)|psi-mi:Adcy2(display_short)|uniprotkb:Adenylate cyclase type II(gene name synonym)|uniprotkb:ATP pyrophosphate-lyase 2(gene name synonym)|uniprotkb:Adenylyl cyclase 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Halls et al. (2010)	pubmed:20664520|imex:IM-15121|mint:MINT-8041780|doi:10.1038/emboj.2010.168	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8095518|mint:MINT-8041863|imex:IM-15121-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1642831(isoform-parent)|ensembl:ENSG00000113448(gene)|ensembl:ENST00000360047(transcript)|mint:MINT-8041877(identity)	go:"GO:0000287"(magnesium ion binding)|go:"GO:0004016"(adenylate cyclase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006171"(cAMP biosynthetic process)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0016020"(membrane)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030425"(dendrite)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045121"(membrane raft)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)|interpro:IPR009398(Adenylate cyclase-like)|interpro:IPR018297|interpro:IPR029787|interpro:IPR030672|rcsb pdb:1AB8|rcsb pdb:1AZS|rcsb pdb:1CJK|rcsb pdb:1CJT|rcsb pdb:1CJU|rcsb pdb:1CJV|rcsb pdb:1CS4|rcsb pdb:1CUL|rcsb pdb:1TL7|rcsb pdb:1U0H|rcsb pdb:2GVD|rcsb pdb:2GVZ|rcsb pdb:3C14|rcsb pdb:3C15|rcsb pdb:3C16|rcsb pdb:3G82|rcsb pdb:3MAA|interpro:IPR032628|rgd:619965|refseq:NP_112269.1|reactome:R-RNO-163615|dip:DIP-164N|reactome:R-RNO-170660|reactome:R-RNO-170670|reactome:R-RNO-418597|reactome:R-RNO-5610787|mint:MINT-8041865(identity)	-	isoform-comment:Contains a phosphoserine at position 54. Activated by phosphorylation at Ser-53. Mutagenesis of Ser-54 abolishes activation.|comment:mint	-	figure legend:f7a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/10/04	2014/10/16	rogid:SCJsnMndW2xYbXz1n1TPl76wwis9606	rogid:Zk3Wd0QamiwHrFeiB9vVGo54A4s10116	intact-crc:B1030EE980AAD38A|rigid:Q7h4IJCsvKFNSMx/147qdZY0W+k	false	-	ha tag:?-?(MINT-8041866)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q08499-2	uniprotkb:P24588	intact:EBI-8095525|intact:MINT-92306|ensembl:ENSP00000353152	intact:EBI-703640|uniprotkb:A2RRB8|ensembl:ENSP00000315615|ensembl:ENSP00000378207	psi-mi:q08499-2(display_long)|uniprotkb:PDE4D(gene name)|psi-mi:PDE4D(display_short)|uniprotkb:DPDE3(gene name synonym)|uniprotkb:PDE43(gene name synonym)|uniprotkb:hPDE4D3(isoform synonym)	psi-mi:akap5_human(display_long)|uniprotkb:A-kinase anchor protein 79 kDa(gene name synonym)|uniprotkb:cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein(gene name synonym)|uniprotkb:H21(gene name synonym)|uniprotkb:AKAP5(gene name)|psi-mi:AKAP5(display_short)|uniprotkb:AKAP79(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Halls et al. (2010)	pubmed:20664520|imex:IM-15121|mint:MINT-8041780|doi:10.1038/emboj.2010.168	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8095518|mint:MINT-8041863|imex:IM-15121-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1642831(isoform-parent)|ensembl:ENSG00000113448(gene)|ensembl:ENST00000360047(transcript)|mint:MINT-8041877(identity)	refseq:NP_004848.3|dip:DIP-186N|ensembl:ENSG00000179841(gene)|ensembl:ENST00000320636(transcript)|ensembl:ENST00000394718(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098837"(postsynaptic recycling endosome)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905751"(positive regulation of endosome to plasma membrane protein transport)|interpro:IPR001573(Protein kinase A anchoring region)|interpro:IPR042375|mint:P24588|rcsb pdb:2H9R|rcsb pdb:3LL8|rcsb pdb:5NIN|reactome:R-HSA-381676|reactome:R-HSA-399719|reactome:R-HSA-9010642|mint:MINT-8041869(identity)	-	isoform-comment:Contains a phosphoserine at position 54. Activated by phosphorylation at Ser-53. Mutagenesis of Ser-54 abolishes activation.|comment:mint	-	figure legend:f7a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/10/04	2014/10/16	rogid:SCJsnMndW2xYbXz1n1TPl76wwis9606	rogid:sprVt4+r5Bkdl+FVefWWqs783y09606	intact-crc:B1030EE980AAD38A|rigid:Q7h4IJCsvKFNSMx/147qdZY0W+k	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q08499-2	uniprotkb:P32121	intact:EBI-8095525|intact:MINT-92306|ensembl:ENSP00000353152	intact:EBI-714559|uniprotkb:Q0Z8D3|uniprotkb:Q2PP19|uniprotkb:Q6ICT3|uniprotkb:Q8N7Y2|uniprotkb:Q9UEQ6|uniprotkb:B7WPL3|uniprotkb:B5B0C0|uniprotkb:D3DTK2|intact:EBI-28974065|ensembl:ENSP00000269260|uniprotkb:B4DLW0|uniprotkb:H0Y688	psi-mi:q08499-2(display_long)|uniprotkb:PDE4D(gene name)|psi-mi:PDE4D(display_short)|uniprotkb:DPDE3(gene name synonym)|uniprotkb:PDE43(gene name synonym)|uniprotkb:hPDE4D3(isoform synonym)	psi-mi:arrb2_human(display_long)|uniprotkb:Arrestin beta-2(gene name synonym)|uniprotkb:ARRB2(gene name)|psi-mi:ARRB2(display_short)|uniprotkb:ARB2(gene name synonym)|uniprotkb:ARR2(gene name synonym)|uniprotkb:Non-visual arrestin-3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Halls et al. (2010)	pubmed:20664520|imex:IM-15121|mint:MINT-8041780|doi:10.1038/emboj.2010.168	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8095518|mint:MINT-8041863|imex:IM-15121-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1642831(isoform-parent)|ensembl:ENSG00000113448(gene)|ensembl:ENST00000360047(transcript)|mint:MINT-8041877(identity)	ensembl:ENSP00000269260|ensembl:ENST00000346341|ensembl:ENSP00000341895|ensembl:ENST00000381488|ensembl:ENSP00000370898|ensembl:ENST00000412477|ensembl:ENSP00000403701|ensembl:ENSG00000141480(gene)|ensembl:ENST00000269260(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|interpro:IPR017864|go:"GO:0005634"(nucleus)|mint:P32121|reactome:R-HSA-2122948|reactome:R-HSA-418555|reactome:R-HSA-456926|reactome:R-HSA-5099900|reactome:R-HSA-5635838|reactome:R-HSA-5674135|reactome:R-HSA-5689880|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9649948|reactome:R-HSA-9656223|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031859"(platelet activating factor receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0005829"(cytosol)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0005886"(plasma membrane)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:0007212"(dopamine receptor signaling pathway)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|go:"GO:0007420"(brain development)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|go:"GO:0007628"(adult walking behavior)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|refseq:NP_004304.1|refseq:NP_945355.1|refseq:NP_001316993.1|refseq:NP_001244259.1|refseq:NP_001244260.1|refseq:NP_001244257.1|refseq:NP_001244258.1|dip:DIP-40089N|mint:MINT-8041875(identity)	-	isoform-comment:Contains a phosphoserine at position 54. Activated by phosphorylation at Ser-53. Mutagenesis of Ser-54 abolishes activation.|comment:mint	-	figure legend:f7a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/10/04	2014/10/16	rogid:SCJsnMndW2xYbXz1n1TPl76wwis9606	rogid:MY34flMH9cdhPtMLGYOQtoQyr2U9606	intact-crc:B1030EE980AAD38A|rigid:Q7h4IJCsvKFNSMx/147qdZY0W+k	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q08499-2	uniprotkb:P26769	intact:EBI-8095525|intact:MINT-92306|ensembl:ENSP00000353152	intact:EBI-1027877	psi-mi:q08499-2(display_long)|uniprotkb:PDE4D(gene name)|psi-mi:PDE4D(display_short)|uniprotkb:DPDE3(gene name synonym)|uniprotkb:PDE43(gene name synonym)|uniprotkb:hPDE4D3(isoform synonym)	psi-mi:adcy2_rat(display_long)|uniprotkb:Adcy2(gene name)|psi-mi:Adcy2(display_short)|uniprotkb:Adenylate cyclase type II(gene name synonym)|uniprotkb:ATP pyrophosphate-lyase 2(gene name synonym)|uniprotkb:Adenylyl cyclase 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Halls et al. (2010)	pubmed:20664520|imex:IM-15121|mint:MINT-8041780|doi:10.1038/emboj.2010.168	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8095611|mint:MINT-8042688|imex:IM-15121-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1642831(isoform-parent)|ensembl:ENSG00000113448(gene)|ensembl:ENST00000360047(transcript)|mint:MINT-8042704(identity)	go:"GO:0000287"(magnesium ion binding)|go:"GO:0004016"(adenylate cyclase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006171"(cAMP biosynthetic process)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0016020"(membrane)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030425"(dendrite)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045121"(membrane raft)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)|interpro:IPR009398(Adenylate cyclase-like)|interpro:IPR018297|interpro:IPR029787|interpro:IPR030672|rcsb pdb:1AB8|rcsb pdb:1AZS|rcsb pdb:1CJK|rcsb pdb:1CJT|rcsb pdb:1CJU|rcsb pdb:1CJV|rcsb pdb:1CS4|rcsb pdb:1CUL|rcsb pdb:1TL7|rcsb pdb:1U0H|rcsb pdb:2GVD|rcsb pdb:2GVZ|rcsb pdb:3C14|rcsb pdb:3C15|rcsb pdb:3C16|rcsb pdb:3G82|rcsb pdb:3MAA|interpro:IPR032628|rgd:619965|refseq:NP_112269.1|reactome:R-RNO-163615|dip:DIP-164N|reactome:R-RNO-170660|reactome:R-RNO-170670|reactome:R-RNO-418597|reactome:R-RNO-5610787|mint:MINT-8042690(identity)	-	isoform-comment:Contains a phosphoserine at position 54. Activated by phosphorylation at Ser-53. Mutagenesis of Ser-54 abolishes activation.|comment:mint	-	figure legend:f7a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/10/04	2014/10/16	rogid:SCJsnMndW2xYbXz1n1TPl76wwis9606	rogid:Zk3Wd0QamiwHrFeiB9vVGo54A4s10116	intact-crc:9986CDC07A2A8E91|rigid:yDwXhNXromXD5WZYuMsTHu3nUzE	false	-	ha tag:?-?(MINT-8042691)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P26769	uniprotkb:P17612	intact:EBI-1027877	intact:EBI-476586|uniprotkb:Q32P54|uniprotkb:Q9H2Y0|uniprotkb:Q9NRB4|uniprotkb:Q9NRH9|ensembl:ENSP00000309591|ensembl:ENSP00000499940	psi-mi:adcy2_rat(display_long)|uniprotkb:Adcy2(gene name)|psi-mi:Adcy2(display_short)|uniprotkb:Adenylate cyclase type II(gene name synonym)|uniprotkb:ATP pyrophosphate-lyase 2(gene name synonym)|uniprotkb:Adenylyl cyclase 2(gene name synonym)	psi-mi:kapca_human(display_long)|uniprotkb:PRKACA(gene name)|psi-mi:PRKACA(display_short)|uniprotkb:PKACA(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Halls et al. (2010)	pubmed:20664520|imex:IM-15121|mint:MINT-8041780|doi:10.1038/emboj.2010.168	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8095713|mint:MINT-8041836|imex:IM-15121-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000287"(magnesium ion binding)|go:"GO:0004016"(adenylate cyclase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006171"(cAMP biosynthetic process)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0016020"(membrane)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030425"(dendrite)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045121"(membrane raft)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)|interpro:IPR009398(Adenylate cyclase-like)|interpro:IPR018297|interpro:IPR029787|interpro:IPR030672|rcsb pdb:1AB8|rcsb pdb:1AZS|rcsb pdb:1CJK|rcsb pdb:1CJT|rcsb pdb:1CJU|rcsb pdb:1CJV|rcsb pdb:1CS4|rcsb pdb:1CUL|rcsb pdb:1TL7|rcsb pdb:1U0H|rcsb pdb:2GVD|rcsb pdb:2GVZ|rcsb pdb:3C14|rcsb pdb:3C15|rcsb pdb:3C16|rcsb pdb:3G82|rcsb pdb:3MAA|interpro:IPR032628|rgd:619965|refseq:NP_112269.1|reactome:R-RNO-163615|dip:DIP-164N|reactome:R-RNO-170660|reactome:R-RNO-170670|reactome:R-RNO-418597|reactome:R-RNO-5610787|mint:MINT-8041838(identity)	refseq:NP_002721.1|refseq:NP_997401.1|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|ensembl:ENSG00000072062(gene)|ensembl:ENSG00000288516(gene)|ensembl:ENST00000308677(transcript)|ensembl:ENST00000673550(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001843"(neural tube closure)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0036126"(sperm flagellum)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0048240"(sperm capacitation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070613"(regulation of protein processing)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097546"(ciliary base)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|go:"GO:0046827"(positive regulation of protein export from nucleus)|rcsb pdb:5IZJ|rcsb pdb:5J5X|rcsb pdb:5N23|rcsb pdb:5UZK|rcsb pdb:6BYR|rcsb pdb:6BYS|rcsb pdb:6C0U|rcsb pdb:6FRX|rcsb pdb:6NO7|rcsb pdb:6QJ7|rcsb pdb:6WJF|rcsb pdb:6WJG|reactome:R-HSA-111931|reactome:R-HSA-163358|reactome:R-HSA-163560|reactome:R-HSA-163615|reactome:R-HSA-164378|reactome:R-HSA-180024|reactome:R-HSA-2565942|reactome:R-HSA-380259|rcsb pdb:3MVJ|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:3NX8|interpro:IPR044109|rcsb pdb:3OOG|rcsb pdb:3OVV|rcsb pdb:3OWP|rcsb pdb:3OXT|rcsb pdb:3P0M|mint:P17612|rcsb pdb:3POO|rcsb pdb:3VQH|rcsb pdb:4AE6|rcsb pdb:2GU8|rcsb pdb:4AE9|rcsb pdb:4UJ1|rcsb pdb:4UJ2|rcsb pdb:3AGL|rcsb pdb:3AGM|rcsb pdb:3AMA|rcsb pdb:3AMB|rcsb pdb:4UJ9|rcsb pdb:4UJA|rcsb pdb:4UJB|rcsb pdb:4WB5|rcsb pdb:4WB6|rcsb pdb:4WB7|rcsb pdb:3L9L|rcsb pdb:3L9M|rcsb pdb:3L9N|rcsb pdb:4WB8|rcsb pdb:5BX6|rcsb pdb:5BX7|rcsb pdb:5IZF|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-381676|reactome:R-HSA-392517|reactome:R-HSA-422356|reactome:R-HSA-432040|reactome:R-HSA-4420097|reactome:R-HSA-442720|reactome:R-HSA-512988|reactome:R-HSA-5578775|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5610787|reactome:R-HSA-5620912|reactome:R-HSA-5621575|reactome:R-HSA-5687128|reactome:R-HSA-8853659|reactome:R-HSA-8854518|reactome:R-HSA-380320|reactome:R-HSA-8963896|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9634600|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-983231|reactome:R-HSA-9010642|refseq:NP_001291278.1|dip:DIP-33878N|mint:MINT-8041843(identity)	-	-	-	figure legend:f7a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/10/04	2014/10/16	rogid:Zk3Wd0QamiwHrFeiB9vVGo54A4s10116	rogid:7yhAi67qjSKPIff2dwqjScPXEYM9606	intact-crc:00B48903C0F442C1|rigid:Q7h4IJCsvKFNSMx/147qdZY0W+k	false	ha tag:?-?(MINT-8041847)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:P26769	uniprotkb:Q9HBX9	intact:EBI-1027877	intact:EBI-8088969|uniprotkb:Q3KU24|uniprotkb:Q3KU25|uniprotkb:Q3KU26|uniprotkb:Q2M215|intact:MINT-231156|uniprotkb:B4DTV2|uniprotkb:B4DHD1|ensembl:ENSP00000303248	psi-mi:adcy2_rat(display_long)|uniprotkb:Adcy2(gene name)|psi-mi:Adcy2(display_short)|uniprotkb:Adenylate cyclase type II(gene name synonym)|uniprotkb:ATP pyrophosphate-lyase 2(gene name synonym)|uniprotkb:Adenylyl cyclase 2(gene name synonym)	psi-mi:rxfp1_human(display_long)|uniprotkb:RXFP1(gene name)|psi-mi:RXFP1(display_short)|uniprotkb:LGR7(gene name synonym)|uniprotkb:Relaxin family peptide receptor 1(gene name synonym)|uniprotkb:Leucine-rich repeat-containing G-protein coupled receptor 7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Halls et al. (2010)	pubmed:20664520|imex:IM-15121|mint:MINT-8041780|doi:10.1038/emboj.2010.168	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8095713|mint:MINT-8041836|imex:IM-15121-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000287"(magnesium ion binding)|go:"GO:0004016"(adenylate cyclase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006171"(cAMP biosynthetic process)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0016020"(membrane)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030425"(dendrite)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045121"(membrane raft)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)|interpro:IPR009398(Adenylate cyclase-like)|interpro:IPR018297|interpro:IPR029787|interpro:IPR030672|rcsb pdb:1AB8|rcsb pdb:1AZS|rcsb pdb:1CJK|rcsb pdb:1CJT|rcsb pdb:1CJU|rcsb pdb:1CJV|rcsb pdb:1CS4|rcsb pdb:1CUL|rcsb pdb:1TL7|rcsb pdb:1U0H|rcsb pdb:2GVD|rcsb pdb:2GVZ|rcsb pdb:3C14|rcsb pdb:3C15|rcsb pdb:3C16|rcsb pdb:3G82|rcsb pdb:3MAA|interpro:IPR032628|rgd:619965|refseq:NP_112269.1|reactome:R-RNO-163615|dip:DIP-164N|reactome:R-RNO-170660|reactome:R-RNO-170670|reactome:R-RNO-418597|reactome:R-RNO-5610787|mint:MINT-8041838(identity)	refseq:NP_067647.2|refseq:NP_001240657.1|refseq:NP_001240658.1|ensembl:ENSG00000171509(gene)|ensembl:ENST00000307765(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007567"(parturition)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0042562"(hormone binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060427"(lung connective tissue development)|go:"GO:0060658"(nipple morphogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR008112(Relaxin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR023415|interpro:IPR032675|interpro:IPR036055|rcsb pdb:2JM4|rcsb pdb:2M7P|reactome:R-HSA-418555|reactome:R-HSA-444821|reactome:R-HSA-9660821|mint:MINT-8041840(identity)	-	-	function:Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP|comment:mint	figure legend:f7a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/10/04	2014/10/16	rogid:Zk3Wd0QamiwHrFeiB9vVGo54A4s10116	rogid:8flEswbzhb+rQGfn16DgFOLTJlg9606	intact-crc:00B48903C0F442C1|rigid:Q7h4IJCsvKFNSMx/147qdZY0W+k	false	ha tag:?-?(MINT-8041847)	flag tag:?-?(MINT-8041853)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P26769	uniprotkb:Q08499-2	intact:EBI-1027877	intact:EBI-8095525|intact:MINT-92306|ensembl:ENSP00000353152	psi-mi:adcy2_rat(display_long)|uniprotkb:Adcy2(gene name)|psi-mi:Adcy2(display_short)|uniprotkb:Adenylate cyclase type II(gene name synonym)|uniprotkb:ATP pyrophosphate-lyase 2(gene name synonym)|uniprotkb:Adenylyl cyclase 2(gene name synonym)	psi-mi:q08499-2(display_long)|uniprotkb:PDE4D(gene name)|psi-mi:PDE4D(display_short)|uniprotkb:DPDE3(gene name synonym)|uniprotkb:PDE43(gene name synonym)|uniprotkb:hPDE4D3(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Halls et al. (2010)	pubmed:20664520|imex:IM-15121|mint:MINT-8041780|doi:10.1038/emboj.2010.168	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8095713|mint:MINT-8041836|imex:IM-15121-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000287"(magnesium ion binding)|go:"GO:0004016"(adenylate cyclase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006171"(cAMP biosynthetic process)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0016020"(membrane)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030425"(dendrite)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045121"(membrane raft)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)|interpro:IPR009398(Adenylate cyclase-like)|interpro:IPR018297|interpro:IPR029787|interpro:IPR030672|rcsb pdb:1AB8|rcsb pdb:1AZS|rcsb pdb:1CJK|rcsb pdb:1CJT|rcsb pdb:1CJU|rcsb pdb:1CJV|rcsb pdb:1CS4|rcsb pdb:1CUL|rcsb pdb:1TL7|rcsb pdb:1U0H|rcsb pdb:2GVD|rcsb pdb:2GVZ|rcsb pdb:3C14|rcsb pdb:3C15|rcsb pdb:3C16|rcsb pdb:3G82|rcsb pdb:3MAA|interpro:IPR032628|rgd:619965|refseq:NP_112269.1|reactome:R-RNO-163615|dip:DIP-164N|reactome:R-RNO-170660|reactome:R-RNO-170670|reactome:R-RNO-418597|reactome:R-RNO-5610787|mint:MINT-8041838(identity)	intact:EBI-1642831(isoform-parent)|ensembl:ENSG00000113448(gene)|ensembl:ENST00000360047(transcript)|mint:MINT-8041842(identity)	-	-	isoform-comment:Contains a phosphoserine at position 54. Activated by phosphorylation at Ser-53. Mutagenesis of Ser-54 abolishes activation.|comment:mint	figure legend:f7a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/10/04	2014/10/16	rogid:Zk3Wd0QamiwHrFeiB9vVGo54A4s10116	rogid:SCJsnMndW2xYbXz1n1TPl76wwis9606	intact-crc:00B48903C0F442C1|rigid:Q7h4IJCsvKFNSMx/147qdZY0W+k	false	ha tag:?-?(MINT-8041847)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:P26769	uniprotkb:P24588	intact:EBI-1027877	intact:EBI-703640|uniprotkb:A2RRB8|ensembl:ENSP00000315615|ensembl:ENSP00000378207	psi-mi:adcy2_rat(display_long)|uniprotkb:Adcy2(gene name)|psi-mi:Adcy2(display_short)|uniprotkb:Adenylate cyclase type II(gene name synonym)|uniprotkb:ATP pyrophosphate-lyase 2(gene name synonym)|uniprotkb:Adenylyl cyclase 2(gene name synonym)	psi-mi:akap5_human(display_long)|uniprotkb:A-kinase anchor protein 79 kDa(gene name synonym)|uniprotkb:cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein(gene name synonym)|uniprotkb:H21(gene name synonym)|uniprotkb:AKAP5(gene name)|psi-mi:AKAP5(display_short)|uniprotkb:AKAP79(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Halls et al. (2010)	pubmed:20664520|imex:IM-15121|mint:MINT-8041780|doi:10.1038/emboj.2010.168	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8095713|mint:MINT-8041836|imex:IM-15121-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000287"(magnesium ion binding)|go:"GO:0004016"(adenylate cyclase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006171"(cAMP biosynthetic process)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0016020"(membrane)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030425"(dendrite)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045121"(membrane raft)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)|interpro:IPR009398(Adenylate cyclase-like)|interpro:IPR018297|interpro:IPR029787|interpro:IPR030672|rcsb pdb:1AB8|rcsb pdb:1AZS|rcsb pdb:1CJK|rcsb pdb:1CJT|rcsb pdb:1CJU|rcsb pdb:1CJV|rcsb pdb:1CS4|rcsb pdb:1CUL|rcsb pdb:1TL7|rcsb pdb:1U0H|rcsb pdb:2GVD|rcsb pdb:2GVZ|rcsb pdb:3C14|rcsb pdb:3C15|rcsb pdb:3C16|rcsb pdb:3G82|rcsb pdb:3MAA|interpro:IPR032628|rgd:619965|refseq:NP_112269.1|reactome:R-RNO-163615|dip:DIP-164N|reactome:R-RNO-170660|reactome:R-RNO-170670|reactome:R-RNO-418597|reactome:R-RNO-5610787|mint:MINT-8041838(identity)	refseq:NP_004848.3|dip:DIP-186N|ensembl:ENSG00000179841(gene)|ensembl:ENST00000320636(transcript)|ensembl:ENST00000394718(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098837"(postsynaptic recycling endosome)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905751"(positive regulation of endosome to plasma membrane protein transport)|interpro:IPR001573(Protein kinase A anchoring region)|interpro:IPR042375|mint:P24588|rcsb pdb:2H9R|rcsb pdb:3LL8|rcsb pdb:5NIN|reactome:R-HSA-381676|reactome:R-HSA-399719|reactome:R-HSA-9010642|mint:MINT-8041839(identity)	-	-	-	figure legend:f7a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/10/04	2014/10/16	rogid:Zk3Wd0QamiwHrFeiB9vVGo54A4s10116	rogid:sprVt4+r5Bkdl+FVefWWqs783y09606	intact-crc:00B48903C0F442C1|rigid:Q7h4IJCsvKFNSMx/147qdZY0W+k	false	ha tag:?-?(MINT-8041847)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:P26769	uniprotkb:P32121	intact:EBI-1027877	intact:EBI-714559|uniprotkb:Q0Z8D3|uniprotkb:Q2PP19|uniprotkb:Q6ICT3|uniprotkb:Q8N7Y2|uniprotkb:Q9UEQ6|uniprotkb:B7WPL3|uniprotkb:B5B0C0|uniprotkb:D3DTK2|intact:EBI-28974065|ensembl:ENSP00000269260|uniprotkb:B4DLW0|uniprotkb:H0Y688	psi-mi:adcy2_rat(display_long)|uniprotkb:Adcy2(gene name)|psi-mi:Adcy2(display_short)|uniprotkb:Adenylate cyclase type II(gene name synonym)|uniprotkb:ATP pyrophosphate-lyase 2(gene name synonym)|uniprotkb:Adenylyl cyclase 2(gene name synonym)	psi-mi:arrb2_human(display_long)|uniprotkb:Arrestin beta-2(gene name synonym)|uniprotkb:ARRB2(gene name)|psi-mi:ARRB2(display_short)|uniprotkb:ARB2(gene name synonym)|uniprotkb:ARR2(gene name synonym)|uniprotkb:Non-visual arrestin-3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Halls et al. (2010)	pubmed:20664520|imex:IM-15121|mint:MINT-8041780|doi:10.1038/emboj.2010.168	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8095713|mint:MINT-8041836|imex:IM-15121-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000287"(magnesium ion binding)|go:"GO:0004016"(adenylate cyclase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006171"(cAMP biosynthetic process)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0016020"(membrane)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030425"(dendrite)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045121"(membrane raft)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)|interpro:IPR009398(Adenylate cyclase-like)|interpro:IPR018297|interpro:IPR029787|interpro:IPR030672|rcsb pdb:1AB8|rcsb pdb:1AZS|rcsb pdb:1CJK|rcsb pdb:1CJT|rcsb pdb:1CJU|rcsb pdb:1CJV|rcsb pdb:1CS4|rcsb pdb:1CUL|rcsb pdb:1TL7|rcsb pdb:1U0H|rcsb pdb:2GVD|rcsb pdb:2GVZ|rcsb pdb:3C14|rcsb pdb:3C15|rcsb pdb:3C16|rcsb pdb:3G82|rcsb pdb:3MAA|interpro:IPR032628|rgd:619965|refseq:NP_112269.1|reactome:R-RNO-163615|dip:DIP-164N|reactome:R-RNO-170660|reactome:R-RNO-170670|reactome:R-RNO-418597|reactome:R-RNO-5610787|mint:MINT-8041838(identity)	ensembl:ENSP00000269260|ensembl:ENST00000346341|ensembl:ENSP00000341895|ensembl:ENST00000381488|ensembl:ENSP00000370898|ensembl:ENST00000412477|ensembl:ENSP00000403701|ensembl:ENSG00000141480(gene)|ensembl:ENST00000269260(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|interpro:IPR017864|go:"GO:0005634"(nucleus)|mint:P32121|reactome:R-HSA-2122948|reactome:R-HSA-418555|reactome:R-HSA-456926|reactome:R-HSA-5099900|reactome:R-HSA-5635838|reactome:R-HSA-5674135|reactome:R-HSA-5689880|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9649948|reactome:R-HSA-9656223|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031859"(platelet activating factor receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0005829"(cytosol)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0005886"(plasma membrane)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:0007212"(dopamine receptor signaling pathway)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|go:"GO:0007420"(brain development)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|go:"GO:0007628"(adult walking behavior)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|refseq:NP_004304.1|refseq:NP_945355.1|refseq:NP_001316993.1|refseq:NP_001244259.1|refseq:NP_001244260.1|refseq:NP_001244257.1|refseq:NP_001244258.1|dip:DIP-40089N|mint:MINT-8041841(identity)	-	-	-	figure legend:f7a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/10/04	2014/10/16	rogid:Zk3Wd0QamiwHrFeiB9vVGo54A4s10116	rogid:MY34flMH9cdhPtMLGYOQtoQyr2U9606	intact-crc:00B48903C0F442C1|rigid:Q7h4IJCsvKFNSMx/147qdZY0W+k	false	ha tag:?-?(MINT-8041847)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:P26769	uniprotkb:P17612	intact:EBI-1027877	intact:EBI-476586|uniprotkb:Q32P54|uniprotkb:Q9H2Y0|uniprotkb:Q9NRB4|uniprotkb:Q9NRH9|ensembl:ENSP00000309591|ensembl:ENSP00000499940	psi-mi:adcy2_rat(display_long)|uniprotkb:Adcy2(gene name)|psi-mi:Adcy2(display_short)|uniprotkb:Adenylate cyclase type II(gene name synonym)|uniprotkb:ATP pyrophosphate-lyase 2(gene name synonym)|uniprotkb:Adenylyl cyclase 2(gene name synonym)	psi-mi:kapca_human(display_long)|uniprotkb:PRKACA(gene name)|psi-mi:PRKACA(display_short)|uniprotkb:PKACA(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Halls et al. (2010)	pubmed:20664520|imex:IM-15121|mint:MINT-8041780|doi:10.1038/emboj.2010.168	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8095758|mint:MINT-8042665|imex:IM-15121-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000287"(magnesium ion binding)|go:"GO:0004016"(adenylate cyclase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006171"(cAMP biosynthetic process)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0016020"(membrane)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030425"(dendrite)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045121"(membrane raft)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)|interpro:IPR009398(Adenylate cyclase-like)|interpro:IPR018297|interpro:IPR029787|interpro:IPR030672|rcsb pdb:1AB8|rcsb pdb:1AZS|rcsb pdb:1CJK|rcsb pdb:1CJT|rcsb pdb:1CJU|rcsb pdb:1CJV|rcsb pdb:1CS4|rcsb pdb:1CUL|rcsb pdb:1TL7|rcsb pdb:1U0H|rcsb pdb:2GVD|rcsb pdb:2GVZ|rcsb pdb:3C14|rcsb pdb:3C15|rcsb pdb:3C16|rcsb pdb:3G82|rcsb pdb:3MAA|interpro:IPR032628|rgd:619965|refseq:NP_112269.1|reactome:R-RNO-163615|dip:DIP-164N|reactome:R-RNO-170660|reactome:R-RNO-170670|reactome:R-RNO-418597|reactome:R-RNO-5610787|mint:MINT-8042667(identity)	refseq:NP_002721.1|refseq:NP_997401.1|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|ensembl:ENSG00000072062(gene)|ensembl:ENSG00000288516(gene)|ensembl:ENST00000308677(transcript)|ensembl:ENST00000673550(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001843"(neural tube closure)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0036126"(sperm flagellum)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0048240"(sperm capacitation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070613"(regulation of protein processing)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097546"(ciliary base)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|go:"GO:0046827"(positive regulation of protein export from nucleus)|rcsb pdb:5IZJ|rcsb pdb:5J5X|rcsb pdb:5N23|rcsb pdb:5UZK|rcsb pdb:6BYR|rcsb pdb:6BYS|rcsb pdb:6C0U|rcsb pdb:6FRX|rcsb pdb:6NO7|rcsb pdb:6QJ7|rcsb pdb:6WJF|rcsb pdb:6WJG|reactome:R-HSA-111931|reactome:R-HSA-163358|reactome:R-HSA-163560|reactome:R-HSA-163615|reactome:R-HSA-164378|reactome:R-HSA-180024|reactome:R-HSA-2565942|reactome:R-HSA-380259|rcsb pdb:3MVJ|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:3NX8|interpro:IPR044109|rcsb pdb:3OOG|rcsb pdb:3OVV|rcsb pdb:3OWP|rcsb pdb:3OXT|rcsb pdb:3P0M|mint:P17612|rcsb pdb:3POO|rcsb pdb:3VQH|rcsb pdb:4AE6|rcsb pdb:2GU8|rcsb pdb:4AE9|rcsb pdb:4UJ1|rcsb pdb:4UJ2|rcsb pdb:3AGL|rcsb pdb:3AGM|rcsb pdb:3AMA|rcsb pdb:3AMB|rcsb pdb:4UJ9|rcsb pdb:4UJA|rcsb pdb:4UJB|rcsb pdb:4WB5|rcsb pdb:4WB6|rcsb pdb:4WB7|rcsb pdb:3L9L|rcsb pdb:3L9M|rcsb pdb:3L9N|rcsb pdb:4WB8|rcsb pdb:5BX6|rcsb pdb:5BX7|rcsb pdb:5IZF|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-381676|reactome:R-HSA-392517|reactome:R-HSA-422356|reactome:R-HSA-432040|reactome:R-HSA-4420097|reactome:R-HSA-442720|reactome:R-HSA-512988|reactome:R-HSA-5578775|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5610787|reactome:R-HSA-5620912|reactome:R-HSA-5621575|reactome:R-HSA-5687128|reactome:R-HSA-8853659|reactome:R-HSA-8854518|reactome:R-HSA-380320|reactome:R-HSA-8963896|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9634600|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-983231|reactome:R-HSA-9010642|refseq:NP_001291278.1|dip:DIP-33878N|mint:MINT-8042681(identity)	-	-	-	figure legend:f7a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/10/04	2014/10/16	rogid:Zk3Wd0QamiwHrFeiB9vVGo54A4s10116	rogid:7yhAi67qjSKPIff2dwqjScPXEYM9606	intact-crc:C3FB63B88330FC53|rigid:viR5mI/80YDydhslmoIoTLLleEI	false	ha tag:?-?(MINT-8042668)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:P26769	uniprotkb:P24588	intact:EBI-1027877	intact:EBI-703640|uniprotkb:A2RRB8|ensembl:ENSP00000315615|ensembl:ENSP00000378207	psi-mi:adcy2_rat(display_long)|uniprotkb:Adcy2(gene name)|psi-mi:Adcy2(display_short)|uniprotkb:Adenylate cyclase type II(gene name synonym)|uniprotkb:ATP pyrophosphate-lyase 2(gene name synonym)|uniprotkb:Adenylyl cyclase 2(gene name synonym)	psi-mi:akap5_human(display_long)|uniprotkb:A-kinase anchor protein 79 kDa(gene name synonym)|uniprotkb:cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein(gene name synonym)|uniprotkb:H21(gene name synonym)|uniprotkb:AKAP5(gene name)|psi-mi:AKAP5(display_short)|uniprotkb:AKAP79(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Halls et al. (2010)	pubmed:20664520|imex:IM-15121|mint:MINT-8041780|doi:10.1038/emboj.2010.168	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8095758|mint:MINT-8042665|imex:IM-15121-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000287"(magnesium ion binding)|go:"GO:0004016"(adenylate cyclase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006171"(cAMP biosynthetic process)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0016020"(membrane)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030425"(dendrite)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045121"(membrane raft)|go:"GO:1904322"(cellular response to forskolin)|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)|interpro:IPR009398(Adenylate cyclase-like)|interpro:IPR018297|interpro:IPR029787|interpro:IPR030672|rcsb pdb:1AB8|rcsb pdb:1AZS|rcsb pdb:1CJK|rcsb pdb:1CJT|rcsb pdb:1CJU|rcsb pdb:1CJV|rcsb pdb:1CS4|rcsb pdb:1CUL|rcsb pdb:1TL7|rcsb pdb:1U0H|rcsb pdb:2GVD|rcsb pdb:2GVZ|rcsb pdb:3C14|rcsb pdb:3C15|rcsb pdb:3C16|rcsb pdb:3G82|rcsb pdb:3MAA|interpro:IPR032628|rgd:619965|refseq:NP_112269.1|reactome:R-RNO-163615|dip:DIP-164N|reactome:R-RNO-170660|reactome:R-RNO-170670|reactome:R-RNO-418597|reactome:R-RNO-5610787|mint:MINT-8042667(identity)	refseq:NP_004848.3|dip:DIP-186N|ensembl:ENSG00000179841(gene)|ensembl:ENST00000320636(transcript)|ensembl:ENST00000394718(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098837"(postsynaptic recycling endosome)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905751"(positive regulation of endosome to plasma membrane protein transport)|interpro:IPR001573(Protein kinase A anchoring region)|interpro:IPR042375|mint:P24588|rcsb pdb:2H9R|rcsb pdb:3LL8|rcsb pdb:5NIN|reactome:R-HSA-381676|reactome:R-HSA-399719|reactome:R-HSA-9010642|mint:MINT-8042671(identity)	-	-	-	figure legend:f7a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/10/04	2014/10/16	rogid:Zk3Wd0QamiwHrFeiB9vVGo54A4s10116	rogid:sprVt4+r5Bkdl+FVefWWqs783y09606	intact-crc:C3FB63B88330FC53|rigid:viR5mI/80YDydhslmoIoTLLleEI	false	ha tag:?-?(MINT-8042668)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HBX9	uniprotkb:P17612	intact:EBI-8088969|uniprotkb:Q3KU24|uniprotkb:Q3KU25|uniprotkb:Q3KU26|uniprotkb:Q2M215|intact:MINT-231156|uniprotkb:B4DTV2|uniprotkb:B4DHD1|ensembl:ENSP00000303248	intact:EBI-476586|uniprotkb:Q32P54|uniprotkb:Q9H2Y0|uniprotkb:Q9NRB4|uniprotkb:Q9NRH9|ensembl:ENSP00000309591|ensembl:ENSP00000499940	psi-mi:rxfp1_human(display_long)|uniprotkb:RXFP1(gene name)|psi-mi:RXFP1(display_short)|uniprotkb:LGR7(gene name synonym)|uniprotkb:Relaxin family peptide receptor 1(gene name synonym)|uniprotkb:Leucine-rich repeat-containing G-protein coupled receptor 7(gene name synonym)	psi-mi:kapca_human(display_long)|uniprotkb:PRKACA(gene name)|psi-mi:PRKACA(display_short)|uniprotkb:PKACA(gene name synonym)	psi-mi:"MI:0096"(pull down)	Halls et al. (2010)	pubmed:20664520|imex:IM-15121|mint:MINT-8041780|doi:10.1038/emboj.2010.168	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8095785|mint:MINT-8042714|imex:IM-15121-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067647.2|refseq:NP_001240657.1|refseq:NP_001240658.1|ensembl:ENSG00000171509(gene)|ensembl:ENST00000307765(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007567"(parturition)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0042562"(hormone binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060427"(lung connective tissue development)|go:"GO:0060658"(nipple morphogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR008112(Relaxin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR023415|interpro:IPR032675|interpro:IPR036055|rcsb pdb:2JM4|rcsb pdb:2M7P|reactome:R-HSA-418555|reactome:R-HSA-444821|reactome:R-HSA-9660821|mint:MINT-8042722(identity)	refseq:NP_002721.1|refseq:NP_997401.1|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|ensembl:ENSG00000072062(gene)|ensembl:ENSG00000288516(gene)|ensembl:ENST00000308677(transcript)|ensembl:ENST00000673550(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001843"(neural tube closure)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0036126"(sperm flagellum)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0048240"(sperm capacitation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070613"(regulation of protein processing)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097546"(ciliary base)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|go:"GO:0046827"(positive regulation of protein export from nucleus)|rcsb pdb:5IZJ|rcsb pdb:5J5X|rcsb pdb:5N23|rcsb pdb:5UZK|rcsb pdb:6BYR|rcsb pdb:6BYS|rcsb pdb:6C0U|rcsb pdb:6FRX|rcsb pdb:6NO7|rcsb pdb:6QJ7|rcsb pdb:6WJF|rcsb pdb:6WJG|reactome:R-HSA-111931|reactome:R-HSA-163358|reactome:R-HSA-163560|reactome:R-HSA-163615|reactome:R-HSA-164378|reactome:R-HSA-180024|reactome:R-HSA-2565942|reactome:R-HSA-380259|rcsb pdb:3MVJ|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:3NX8|interpro:IPR044109|rcsb pdb:3OOG|rcsb pdb:3OVV|rcsb pdb:3OWP|rcsb pdb:3OXT|rcsb pdb:3P0M|mint:P17612|rcsb pdb:3POO|rcsb pdb:3VQH|rcsb pdb:4AE6|rcsb pdb:2GU8|rcsb pdb:4AE9|rcsb pdb:4UJ1|rcsb pdb:4UJ2|rcsb pdb:3AGL|rcsb pdb:3AGM|rcsb pdb:3AMA|rcsb pdb:3AMB|rcsb pdb:4UJ9|rcsb pdb:4UJA|rcsb pdb:4UJB|rcsb pdb:4WB5|rcsb pdb:4WB6|rcsb pdb:4WB7|rcsb pdb:3L9L|rcsb pdb:3L9M|rcsb pdb:3L9N|rcsb pdb:4WB8|rcsb pdb:5BX6|rcsb pdb:5BX7|rcsb pdb:5IZF|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-381676|reactome:R-HSA-392517|reactome:R-HSA-422356|reactome:R-HSA-432040|reactome:R-HSA-4420097|reactome:R-HSA-442720|reactome:R-HSA-512988|reactome:R-HSA-5578775|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5610787|reactome:R-HSA-5620912|reactome:R-HSA-5621575|reactome:R-HSA-5687128|reactome:R-HSA-8853659|reactome:R-HSA-8854518|reactome:R-HSA-380320|reactome:R-HSA-8963896|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9634600|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-983231|reactome:R-HSA-9010642|refseq:NP_001291278.1|dip:DIP-33878N|mint:MINT-8042730(identity)	-	function:Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP|comment:mint	-	figure legend:f6b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/10/04	2014/10/16	rogid:8flEswbzhb+rQGfn16DgFOLTJlg9606	rogid:7yhAi67qjSKPIff2dwqjScPXEYM9606	intact-crc:89A2113BF6BFB95F|rigid:7olAdx0g0FY/iKoGuLEMPGRkzVQ	false	glutathione s tranferase tag:?-?(MINT-8042723)|binding-associated region:673-703(MINT-8042736)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HBX9	uniprotkb:Q08499-2	intact:EBI-8088969|uniprotkb:Q3KU24|uniprotkb:Q3KU25|uniprotkb:Q3KU26|uniprotkb:Q2M215|intact:MINT-231156|uniprotkb:B4DTV2|uniprotkb:B4DHD1|ensembl:ENSP00000303248	intact:EBI-8095525|intact:MINT-92306|ensembl:ENSP00000353152	psi-mi:rxfp1_human(display_long)|uniprotkb:RXFP1(gene name)|psi-mi:RXFP1(display_short)|uniprotkb:LGR7(gene name synonym)|uniprotkb:Relaxin family peptide receptor 1(gene name synonym)|uniprotkb:Leucine-rich repeat-containing G-protein coupled receptor 7(gene name synonym)	psi-mi:q08499-2(display_long)|uniprotkb:PDE4D(gene name)|psi-mi:PDE4D(display_short)|uniprotkb:DPDE3(gene name synonym)|uniprotkb:PDE43(gene name synonym)|uniprotkb:hPDE4D3(isoform synonym)	psi-mi:"MI:0096"(pull down)	Halls et al. (2010)	pubmed:20664520|imex:IM-15121|mint:MINT-8041780|doi:10.1038/emboj.2010.168	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8095785|mint:MINT-8042714|imex:IM-15121-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067647.2|refseq:NP_001240657.1|refseq:NP_001240658.1|ensembl:ENSG00000171509(gene)|ensembl:ENST00000307765(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007567"(parturition)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0042562"(hormone binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060427"(lung connective tissue development)|go:"GO:0060658"(nipple morphogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR008112(Relaxin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR023415|interpro:IPR032675|interpro:IPR036055|rcsb pdb:2JM4|rcsb pdb:2M7P|reactome:R-HSA-418555|reactome:R-HSA-444821|reactome:R-HSA-9660821|mint:MINT-8042722(identity)	intact:EBI-1642831(isoform-parent)|ensembl:ENSG00000113448(gene)|ensembl:ENST00000360047(transcript)|mint:MINT-8042728(identity)	-	function:Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP|comment:mint	isoform-comment:Contains a phosphoserine at position 54. Activated by phosphorylation at Ser-53. Mutagenesis of Ser-54 abolishes activation.|comment:mint	figure legend:f6b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/10/04	2014/10/16	rogid:8flEswbzhb+rQGfn16DgFOLTJlg9606	rogid:SCJsnMndW2xYbXz1n1TPl76wwis9606	intact-crc:89A2113BF6BFB95F|rigid:7olAdx0g0FY/iKoGuLEMPGRkzVQ	false	glutathione s tranferase tag:?-?(MINT-8042723)|binding-associated region:673-703(MINT-8042736)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HBX9	uniprotkb:P32121	intact:EBI-8088969|uniprotkb:Q3KU24|uniprotkb:Q3KU25|uniprotkb:Q3KU26|uniprotkb:Q2M215|intact:MINT-231156|uniprotkb:B4DTV2|uniprotkb:B4DHD1|ensembl:ENSP00000303248	intact:EBI-714559|uniprotkb:Q0Z8D3|uniprotkb:Q2PP19|uniprotkb:Q6ICT3|uniprotkb:Q8N7Y2|uniprotkb:Q9UEQ6|uniprotkb:B7WPL3|uniprotkb:B5B0C0|uniprotkb:D3DTK2|intact:EBI-28974065|ensembl:ENSP00000269260|uniprotkb:B4DLW0|uniprotkb:H0Y688	psi-mi:rxfp1_human(display_long)|uniprotkb:RXFP1(gene name)|psi-mi:RXFP1(display_short)|uniprotkb:LGR7(gene name synonym)|uniprotkb:Relaxin family peptide receptor 1(gene name synonym)|uniprotkb:Leucine-rich repeat-containing G-protein coupled receptor 7(gene name synonym)	psi-mi:arrb2_human(display_long)|uniprotkb:Arrestin beta-2(gene name synonym)|uniprotkb:ARRB2(gene name)|psi-mi:ARRB2(display_short)|uniprotkb:ARB2(gene name synonym)|uniprotkb:ARR2(gene name synonym)|uniprotkb:Non-visual arrestin-3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Halls et al. (2010)	pubmed:20664520|imex:IM-15121|mint:MINT-8041780|doi:10.1038/emboj.2010.168	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8095785|mint:MINT-8042714|imex:IM-15121-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067647.2|refseq:NP_001240657.1|refseq:NP_001240658.1|ensembl:ENSG00000171509(gene)|ensembl:ENST00000307765(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007567"(parturition)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0042562"(hormone binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060427"(lung connective tissue development)|go:"GO:0060658"(nipple morphogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR008112(Relaxin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR023415|interpro:IPR032675|interpro:IPR036055|rcsb pdb:2JM4|rcsb pdb:2M7P|reactome:R-HSA-418555|reactome:R-HSA-444821|reactome:R-HSA-9660821|mint:MINT-8042722(identity)	ensembl:ENSP00000269260|ensembl:ENST00000346341|ensembl:ENSP00000341895|ensembl:ENST00000381488|ensembl:ENSP00000370898|ensembl:ENST00000412477|ensembl:ENSP00000403701|ensembl:ENSG00000141480(gene)|ensembl:ENST00000269260(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|interpro:IPR017864|go:"GO:0005634"(nucleus)|mint:P32121|reactome:R-HSA-2122948|reactome:R-HSA-418555|reactome:R-HSA-456926|reactome:R-HSA-5099900|reactome:R-HSA-5635838|reactome:R-HSA-5674135|reactome:R-HSA-5689880|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9649948|reactome:R-HSA-9656223|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031859"(platelet activating factor receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0005829"(cytosol)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0005886"(plasma membrane)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:0007212"(dopamine receptor signaling pathway)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|go:"GO:0007420"(brain development)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|go:"GO:0007628"(adult walking behavior)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|refseq:NP_004304.1|refseq:NP_945355.1|refseq:NP_001316993.1|refseq:NP_001244259.1|refseq:NP_001244260.1|refseq:NP_001244257.1|refseq:NP_001244258.1|dip:DIP-40089N|mint:MINT-8042726(identity)	-	function:Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP|comment:mint	-	figure legend:f6b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/10/04	2014/10/16	rogid:8flEswbzhb+rQGfn16DgFOLTJlg9606	rogid:MY34flMH9cdhPtMLGYOQtoQyr2U9606	intact-crc:89A2113BF6BFB95F|rigid:7olAdx0g0FY/iKoGuLEMPGRkzVQ	false	glutathione s tranferase tag:?-?(MINT-8042723)|binding-associated region:673-703(MINT-8042736)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HBX9	uniprotkb:P24588	intact:EBI-8088969|uniprotkb:Q3KU24|uniprotkb:Q3KU25|uniprotkb:Q3KU26|uniprotkb:Q2M215|intact:MINT-231156|uniprotkb:B4DTV2|uniprotkb:B4DHD1|ensembl:ENSP00000303248	intact:EBI-703640|uniprotkb:A2RRB8|ensembl:ENSP00000315615|ensembl:ENSP00000378207	psi-mi:rxfp1_human(display_long)|uniprotkb:RXFP1(gene name)|psi-mi:RXFP1(display_short)|uniprotkb:LGR7(gene name synonym)|uniprotkb:Relaxin family peptide receptor 1(gene name synonym)|uniprotkb:Leucine-rich repeat-containing G-protein coupled receptor 7(gene name synonym)	psi-mi:akap5_human(display_long)|uniprotkb:A-kinase anchor protein 79 kDa(gene name synonym)|uniprotkb:cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein(gene name synonym)|uniprotkb:H21(gene name synonym)|uniprotkb:AKAP5(gene name)|psi-mi:AKAP5(display_short)|uniprotkb:AKAP79(gene name synonym)	psi-mi:"MI:0096"(pull down)	Halls et al. (2010)	pubmed:20664520|imex:IM-15121|mint:MINT-8041780|doi:10.1038/emboj.2010.168	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8095871|mint:MINT-8042760|imex:IM-15121-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067647.2|refseq:NP_001240657.1|refseq:NP_001240658.1|ensembl:ENSG00000171509(gene)|ensembl:ENST00000307765(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007567"(parturition)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0042562"(hormone binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060427"(lung connective tissue development)|go:"GO:0060658"(nipple morphogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR008112(Relaxin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR023415|interpro:IPR032675|interpro:IPR036055|rcsb pdb:2JM4|rcsb pdb:2M7P|reactome:R-HSA-418555|reactome:R-HSA-444821|reactome:R-HSA-9660821|mint:MINT-8042762(identity)	refseq:NP_004848.3|dip:DIP-186N|ensembl:ENSG00000179841(gene)|ensembl:ENST00000320636(transcript)|ensembl:ENST00000394718(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098837"(postsynaptic recycling endosome)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905751"(positive regulation of endosome to plasma membrane protein transport)|interpro:IPR001573(Protein kinase A anchoring region)|interpro:IPR042375|mint:P24588|rcsb pdb:2H9R|rcsb pdb:3LL8|rcsb pdb:5NIN|reactome:R-HSA-381676|reactome:R-HSA-399719|reactome:R-HSA-9010642|mint:MINT-8042772(identity)	-	function:Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP|comment:mint	-	figure legend:f6c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/10/04	2014/10/16	rogid:8flEswbzhb+rQGfn16DgFOLTJlg9606	rogid:sprVt4+r5Bkdl+FVefWWqs783y09606	intact-crc:68A52436E3418249|rigid:DVFUxduEapiqI16bmLVJ5kuevhM	false	binding-associated region:673-703(MINT-8042765)|glutathione s tranferase tag:?-?(MINT-8042763)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HBX9	uniprotkb:P17612	intact:EBI-8088969|uniprotkb:Q3KU24|uniprotkb:Q3KU25|uniprotkb:Q3KU26|uniprotkb:Q2M215|intact:MINT-231156|uniprotkb:B4DTV2|uniprotkb:B4DHD1|ensembl:ENSP00000303248	intact:EBI-476586|uniprotkb:Q32P54|uniprotkb:Q9H2Y0|uniprotkb:Q9NRB4|uniprotkb:Q9NRH9|ensembl:ENSP00000309591|ensembl:ENSP00000499940	psi-mi:rxfp1_human(display_long)|uniprotkb:RXFP1(gene name)|psi-mi:RXFP1(display_short)|uniprotkb:LGR7(gene name synonym)|uniprotkb:Relaxin family peptide receptor 1(gene name synonym)|uniprotkb:Leucine-rich repeat-containing G-protein coupled receptor 7(gene name synonym)	psi-mi:kapca_human(display_long)|uniprotkb:PRKACA(gene name)|psi-mi:PRKACA(display_short)|uniprotkb:PKACA(gene name synonym)	psi-mi:"MI:0096"(pull down)	Halls et al. (2010)	pubmed:20664520|imex:IM-15121|mint:MINT-8041780|doi:10.1038/emboj.2010.168	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8095830|mint:MINT-8042744|imex:IM-15121-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067647.2|refseq:NP_001240657.1|refseq:NP_001240658.1|ensembl:ENSG00000171509(gene)|ensembl:ENST00000307765(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007567"(parturition)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0042562"(hormone binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060427"(lung connective tissue development)|go:"GO:0060658"(nipple morphogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR008112(Relaxin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR023415|interpro:IPR032675|interpro:IPR036055|rcsb pdb:2JM4|rcsb pdb:2M7P|reactome:R-HSA-418555|reactome:R-HSA-444821|reactome:R-HSA-9660821|mint:MINT-8042746(identity)	refseq:NP_002721.1|refseq:NP_997401.1|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|ensembl:ENSG00000072062(gene)|ensembl:ENSG00000288516(gene)|ensembl:ENST00000308677(transcript)|ensembl:ENST00000673550(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001843"(neural tube closure)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0036126"(sperm flagellum)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0048240"(sperm capacitation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070613"(regulation of protein processing)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097546"(ciliary base)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|go:"GO:0046827"(positive regulation of protein export from nucleus)|rcsb pdb:5IZJ|rcsb pdb:5J5X|rcsb pdb:5N23|rcsb pdb:5UZK|rcsb pdb:6BYR|rcsb pdb:6BYS|rcsb pdb:6C0U|rcsb pdb:6FRX|rcsb pdb:6NO7|rcsb pdb:6QJ7|rcsb pdb:6WJF|rcsb pdb:6WJG|reactome:R-HSA-111931|reactome:R-HSA-163358|reactome:R-HSA-163560|reactome:R-HSA-163615|reactome:R-HSA-164378|reactome:R-HSA-180024|reactome:R-HSA-2565942|reactome:R-HSA-380259|rcsb pdb:3MVJ|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:3NX8|interpro:IPR044109|rcsb pdb:3OOG|rcsb pdb:3OVV|rcsb pdb:3OWP|rcsb pdb:3OXT|rcsb pdb:3P0M|mint:P17612|rcsb pdb:3POO|rcsb pdb:3VQH|rcsb pdb:4AE6|rcsb pdb:2GU8|rcsb pdb:4AE9|rcsb pdb:4UJ1|rcsb pdb:4UJ2|rcsb pdb:3AGL|rcsb pdb:3AGM|rcsb pdb:3AMA|rcsb pdb:3AMB|rcsb pdb:4UJ9|rcsb pdb:4UJA|rcsb pdb:4UJB|rcsb pdb:4WB5|rcsb pdb:4WB6|rcsb pdb:4WB7|rcsb pdb:3L9L|rcsb pdb:3L9M|rcsb pdb:3L9N|rcsb pdb:4WB8|rcsb pdb:5BX6|rcsb pdb:5BX7|rcsb pdb:5IZF|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-381676|reactome:R-HSA-392517|reactome:R-HSA-422356|reactome:R-HSA-432040|reactome:R-HSA-4420097|reactome:R-HSA-442720|reactome:R-HSA-512988|reactome:R-HSA-5578775|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5610787|reactome:R-HSA-5620912|reactome:R-HSA-5621575|reactome:R-HSA-5687128|reactome:R-HSA-8853659|reactome:R-HSA-8854518|reactome:R-HSA-380320|reactome:R-HSA-8963896|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9634600|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-983231|reactome:R-HSA-9010642|refseq:NP_001291278.1|dip:DIP-33878N|mint:MINT-8042756(identity)	-	function:Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP|comment:mint	-	figure legend:f6b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/10/04	2014/10/16	rogid:8flEswbzhb+rQGfn16DgFOLTJlg9606	rogid:7yhAi67qjSKPIff2dwqjScPXEYM9606	intact-crc:71B5091A8AC7AACC|rigid:7olAdx0g0FY/iKoGuLEMPGRkzVQ	false	glutathione s tranferase tag:?-?(MINT-8042747)|binding-associated region:704-725(MINT-8042749)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HBX9	uniprotkb:Q08499-2	intact:EBI-8088969|uniprotkb:Q3KU24|uniprotkb:Q3KU25|uniprotkb:Q3KU26|uniprotkb:Q2M215|intact:MINT-231156|uniprotkb:B4DTV2|uniprotkb:B4DHD1|ensembl:ENSP00000303248	intact:EBI-8095525|intact:MINT-92306|ensembl:ENSP00000353152	psi-mi:rxfp1_human(display_long)|uniprotkb:RXFP1(gene name)|psi-mi:RXFP1(display_short)|uniprotkb:LGR7(gene name synonym)|uniprotkb:Relaxin family peptide receptor 1(gene name synonym)|uniprotkb:Leucine-rich repeat-containing G-protein coupled receptor 7(gene name synonym)	psi-mi:q08499-2(display_long)|uniprotkb:PDE4D(gene name)|psi-mi:PDE4D(display_short)|uniprotkb:DPDE3(gene name synonym)|uniprotkb:PDE43(gene name synonym)|uniprotkb:hPDE4D3(isoform synonym)	psi-mi:"MI:0096"(pull down)	Halls et al. (2010)	pubmed:20664520|imex:IM-15121|mint:MINT-8041780|doi:10.1038/emboj.2010.168	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8095830|mint:MINT-8042744|imex:IM-15121-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067647.2|refseq:NP_001240657.1|refseq:NP_001240658.1|ensembl:ENSG00000171509(gene)|ensembl:ENST00000307765(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007567"(parturition)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0042562"(hormone binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060427"(lung connective tissue development)|go:"GO:0060658"(nipple morphogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR008112(Relaxin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR023415|interpro:IPR032675|interpro:IPR036055|rcsb pdb:2JM4|rcsb pdb:2M7P|reactome:R-HSA-418555|reactome:R-HSA-444821|reactome:R-HSA-9660821|mint:MINT-8042746(identity)	intact:EBI-1642831(isoform-parent)|ensembl:ENSG00000113448(gene)|ensembl:ENST00000360047(transcript)|mint:MINT-8042754(identity)	-	function:Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP|comment:mint	isoform-comment:Contains a phosphoserine at position 54. Activated by phosphorylation at Ser-53. Mutagenesis of Ser-54 abolishes activation.|comment:mint	figure legend:f6b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/10/04	2014/10/16	rogid:8flEswbzhb+rQGfn16DgFOLTJlg9606	rogid:SCJsnMndW2xYbXz1n1TPl76wwis9606	intact-crc:71B5091A8AC7AACC|rigid:7olAdx0g0FY/iKoGuLEMPGRkzVQ	false	glutathione s tranferase tag:?-?(MINT-8042747)|binding-associated region:704-725(MINT-8042749)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HBX9	uniprotkb:P32121	intact:EBI-8088969|uniprotkb:Q3KU24|uniprotkb:Q3KU25|uniprotkb:Q3KU26|uniprotkb:Q2M215|intact:MINT-231156|uniprotkb:B4DTV2|uniprotkb:B4DHD1|ensembl:ENSP00000303248	intact:EBI-714559|uniprotkb:Q0Z8D3|uniprotkb:Q2PP19|uniprotkb:Q6ICT3|uniprotkb:Q8N7Y2|uniprotkb:Q9UEQ6|uniprotkb:B7WPL3|uniprotkb:B5B0C0|uniprotkb:D3DTK2|intact:EBI-28974065|ensembl:ENSP00000269260|uniprotkb:B4DLW0|uniprotkb:H0Y688	psi-mi:rxfp1_human(display_long)|uniprotkb:RXFP1(gene name)|psi-mi:RXFP1(display_short)|uniprotkb:LGR7(gene name synonym)|uniprotkb:Relaxin family peptide receptor 1(gene name synonym)|uniprotkb:Leucine-rich repeat-containing G-protein coupled receptor 7(gene name synonym)	psi-mi:arrb2_human(display_long)|uniprotkb:Arrestin beta-2(gene name synonym)|uniprotkb:ARRB2(gene name)|psi-mi:ARRB2(display_short)|uniprotkb:ARB2(gene name synonym)|uniprotkb:ARR2(gene name synonym)|uniprotkb:Non-visual arrestin-3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Halls et al. (2010)	pubmed:20664520|imex:IM-15121|mint:MINT-8041780|doi:10.1038/emboj.2010.168	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8095830|mint:MINT-8042744|imex:IM-15121-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067647.2|refseq:NP_001240657.1|refseq:NP_001240658.1|ensembl:ENSG00000171509(gene)|ensembl:ENST00000307765(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007567"(parturition)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0042562"(hormone binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060427"(lung connective tissue development)|go:"GO:0060658"(nipple morphogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR008112(Relaxin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR023415|interpro:IPR032675|interpro:IPR036055|rcsb pdb:2JM4|rcsb pdb:2M7P|reactome:R-HSA-418555|reactome:R-HSA-444821|reactome:R-HSA-9660821|mint:MINT-8042746(identity)	ensembl:ENSP00000269260|ensembl:ENST00000346341|ensembl:ENSP00000341895|ensembl:ENST00000381488|ensembl:ENSP00000370898|ensembl:ENST00000412477|ensembl:ENSP00000403701|ensembl:ENSG00000141480(gene)|ensembl:ENST00000269260(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|interpro:IPR017864|go:"GO:0005634"(nucleus)|mint:P32121|reactome:R-HSA-2122948|reactome:R-HSA-418555|reactome:R-HSA-456926|reactome:R-HSA-5099900|reactome:R-HSA-5635838|reactome:R-HSA-5674135|reactome:R-HSA-5689880|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9649948|reactome:R-HSA-9656223|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031859"(platelet activating factor receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0005829"(cytosol)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0005886"(plasma membrane)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:0007212"(dopamine receptor signaling pathway)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|go:"GO:0007420"(brain development)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|go:"GO:0007628"(adult walking behavior)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|refseq:NP_004304.1|refseq:NP_945355.1|refseq:NP_001316993.1|refseq:NP_001244259.1|refseq:NP_001244260.1|refseq:NP_001244257.1|refseq:NP_001244258.1|dip:DIP-40089N|mint:MINT-8042752(identity)	-	function:Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP|comment:mint	-	figure legend:f6b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/10/04	2014/10/16	rogid:8flEswbzhb+rQGfn16DgFOLTJlg9606	rogid:MY34flMH9cdhPtMLGYOQtoQyr2U9606	intact-crc:71B5091A8AC7AACC|rigid:7olAdx0g0FY/iKoGuLEMPGRkzVQ	false	glutathione s tranferase tag:?-?(MINT-8042747)|binding-associated region:704-725(MINT-8042749)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HBX9	uniprotkb:P24588	intact:EBI-8088969|uniprotkb:Q3KU24|uniprotkb:Q3KU25|uniprotkb:Q3KU26|uniprotkb:Q2M215|intact:MINT-231156|uniprotkb:B4DTV2|uniprotkb:B4DHD1|ensembl:ENSP00000303248	intact:EBI-703640|uniprotkb:A2RRB8|ensembl:ENSP00000315615|ensembl:ENSP00000378207	psi-mi:rxfp1_human(display_long)|uniprotkb:RXFP1(gene name)|psi-mi:RXFP1(display_short)|uniprotkb:LGR7(gene name synonym)|uniprotkb:Relaxin family peptide receptor 1(gene name synonym)|uniprotkb:Leucine-rich repeat-containing G-protein coupled receptor 7(gene name synonym)	psi-mi:akap5_human(display_long)|uniprotkb:A-kinase anchor protein 79 kDa(gene name synonym)|uniprotkb:cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein(gene name synonym)|uniprotkb:H21(gene name synonym)|uniprotkb:AKAP5(gene name)|psi-mi:AKAP5(display_short)|uniprotkb:AKAP79(gene name synonym)	psi-mi:"MI:0096"(pull down)	Halls et al. (2010)	pubmed:20664520|imex:IM-15121|mint:MINT-8041780|doi:10.1038/emboj.2010.168	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8095889|mint:MINT-8042779|imex:IM-15121-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067647.2|refseq:NP_001240657.1|refseq:NP_001240658.1|ensembl:ENSG00000171509(gene)|ensembl:ENST00000307765(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007567"(parturition)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0042562"(hormone binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060427"(lung connective tissue development)|go:"GO:0060658"(nipple morphogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR008112(Relaxin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR023415|interpro:IPR032675|interpro:IPR036055|rcsb pdb:2JM4|rcsb pdb:2M7P|reactome:R-HSA-418555|reactome:R-HSA-444821|reactome:R-HSA-9660821|mint:MINT-8042781(identity)	refseq:NP_004848.3|dip:DIP-186N|ensembl:ENSG00000179841(gene)|ensembl:ENST00000320636(transcript)|ensembl:ENST00000394718(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098837"(postsynaptic recycling endosome)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905751"(positive regulation of endosome to plasma membrane protein transport)|interpro:IPR001573(Protein kinase A anchoring region)|interpro:IPR042375|mint:P24588|rcsb pdb:2H9R|rcsb pdb:3LL8|rcsb pdb:5NIN|reactome:R-HSA-381676|reactome:R-HSA-399719|reactome:R-HSA-9010642|mint:MINT-8042787(identity)	-	function:Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP|comment:mint	-	figure legend:f6c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/10/04	2014/10/16	rogid:8flEswbzhb+rQGfn16DgFOLTJlg9606	rogid:sprVt4+r5Bkdl+FVefWWqs783y09606	intact-crc:8EF3D649E8BAAAF0|rigid:DVFUxduEapiqI16bmLVJ5kuevhM	false	glutathione s tranferase tag:?-?(MINT-8042784)|binding-associated region:726-747(MINT-8042782)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)