#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P25713	uniprotkb:P02766	intact:EBI-8084264|intact:MINT-7905812|uniprotkb:Q2V574|ensembl:ENSP00000200691	intact:EBI-711909|ensembl:ENSP00000237014|ensembl:ENSP00000497927|uniprotkb:Q6IB96|uniprotkb:Q9UBZ6|uniprotkb:Q9UCM9|uniprotkb:Q549C7	psi-mi:mt3_human(display_long)|uniprotkb:MT3(gene name)|psi-mi:MT3(display_short)|uniprotkb:Metallothionein-III(gene name synonym)|uniprotkb:Growth inhibitory factor(gene name synonym)|uniprotkb:GIFB(gene name synonym)	psi-mi:tthy_human(display_long)|uniprotkb:Prealbumin(gene name synonym)|uniprotkb:TBPA(gene name synonym)|uniprotkb:ATTR(gene name synonym)|uniprotkb:TTR(gene name)|psi-mi:TTR(display_short)|uniprotkb:PALB(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Martinho et al. (2010)	pubmed:20646067|imex:IM-15603|mint:MINT-7905802|doi:10.1111/j.1742-4658.2010.07749	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8084258|mint:MINT-7905838|imex:IM-15603-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005945.1|go:"GO:0032095"(regulation of response to food)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044242"(cellular lipid catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055073"(cadmium ion homeostasis)|go:"GO:0060049"(regulation of protein glycosylation)|go:"GO:0060547"(negative regulation of necrotic cell death)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071294"(cellular response to zinc ion)|ensembl:ENSG00000087250(gene)|ensembl:ENST00000200691(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005507"(copper ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006707"(cholesterol catabolic process)|go:"GO:0006829"(zinc ion transport)|go:"GO:0006875"(cellular metal ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097214"(positive regulation of lysosomal membrane permeability)|go:"GO:0097450"(astrocyte end-foot)|go:"GO:2000117"(negative regulation of cysteine-type endopeptidase activity)|go:"GO:2000296"(negative regulation of hydrogen peroxide catabolic process)|go:"GO:2000376"(positive regulation of oxygen metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000006(Metallothionein, vertebrate)|interpro:IPR003019(Metallothionein superfamily, eukaryotic)|interpro:IPR017854(Metallothionein superfamily)|interpro:IPR018064|interpro:IPR023587|mint:P25713|rcsb pdb:2F5H|rcsb pdb:2FJ4|rcsb pdb:2FJ5|reactome:R-HSA-5661231|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016209"(antioxidant activity)|go:"GO:0016234"(inclusion body)|go:"GO:0016570"(histone modification)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|mint:MINT-7905841(identity)	rcsb pdb:3GLZ|rcsb pdb:3GPS|rcsb pdb:3GRB|rcsb pdb:3GRG|rcsb pdb:3GS0|rcsb pdb:3GS4|rcsb pdb:3GS7|rcsb pdb:3HJ0|rcsb pdb:3I9A|rcsb pdb:3I9I|rcsb pdb:3I9P|rcsb pdb:3IMR|rcsb pdb:3IMS|rcsb pdb:3IMT|rcsb pdb:3IMU|rcsb pdb:3IMV|rcsb pdb:3IMW|rcsb pdb:3IPB|rcsb pdb:3IPE|rcsb pdb:3KGS|rcsb pdb:3KGT|rcsb pdb:3KGU|rcsb pdb:3M1O|rcsb pdb:3NEE|rcsb pdb:3NEO|rcsb pdb:3NES|rcsb pdb:3NEX|rcsb pdb:3NG5|rcsb pdb:3OZK|rcsb pdb:3OZL|rcsb pdb:3FCB|rcsb pdb:3P3R|rcsb pdb:3P3S|rcsb pdb:3P3T|rcsb pdb:3P3U|rcsb pdb:3SSG|rcsb pdb:3TCT|rcsb pdb:3TFB|rcsb pdb:3U2I|rcsb pdb:3U2J|rcsb pdb:3W3B|rcsb pdb:4ABQ|rcsb pdb:4ABU|rcsb pdb:4ABV|rcsb pdb:4ABW|rcsb pdb:4AC2|rcsb pdb:4AC4|rcsb pdb:4ACT|rcsb pdb:4ANK|rcsb pdb:4D7B|rcsb pdb:4DER|rcsb pdb:4DES|rcsb pdb:4DET|rcsb pdb:4DEU|rcsb pdb:4DEW|rcsb pdb:4FI6|rcsb pdb:4FI7|rcsb pdb:4FI8|rcsb pdb:4HIQ|rcsb pdb:4HIS|rcsb pdb:4HJS|rcsb pdb:4HJT|rcsb pdb:4HJU|rcsb pdb:4I85|rcsb pdb:4I87|rcsb pdb:4IIZ|rcsb pdb:4IK6|rcsb pdb:4IK7|rcsb pdb:4IKI|rcsb pdb:4IKJ|rcsb pdb:4IKK|rcsb pdb:4IKL|rcsb pdb:4KY2|rcsb pdb:4L1S|rcsb pdb:4L1T|rcsb pdb:4MAS|rcsb pdb:4MRB|rcsb pdb:4MRC|rcsb pdb:4N85|rcsb pdb:4N86|rcsb pdb:4N87|rcsb pdb:4PM1|rcsb pdb:4PME|rcsb pdb:4PMF|rcsb pdb:4PVL|rcsb pdb:4PVM|rcsb pdb:4PVN|rcsb pdb:4I89|rcsb pdb:4PWE|rcsb pdb:4PWF|rcsb pdb:4PWG|rcsb pdb:4TLK|rcsb pdb:4TLS|rcsb pdb:4TLT|rcsb pdb:4TLU|rcsb pdb:4TM9|rcsb pdb:4TNE|rcsb pdb:4PWH|rcsb pdb:4TNF|rcsb pdb:4TNG|rcsb pdb:4TQ8|rcsb pdb:4TQH|rcsb pdb:4TQI|rcsb pdb:4TQP|rcsb pdb:4PWI|rcsb pdb:4PWJ|rcsb pdb:4PWK|rcsb pdb:4QRF|rcsb pdb:4WNJ|rcsb pdb:4WNS|rcsb pdb:4QXV|rcsb pdb:4QYA|rcsb pdb:4WO0|rcsb pdb:4TKW|rcsb pdb:4TL4|rcsb pdb:4TL5|rcsb pdb:4Y9B|rcsb pdb:4Y9C|rcsb pdb:4Y9E|rcsb pdb:4Y9F|rcsb pdb:4Y9G|rcsb pdb:4YDM|rcsb pdb:4YDN|rcsb pdb:5A6I|rcsb pdb:5AKS|rcsb pdb:5AKT|rcsb pdb:5AKV|rcsb pdb:5AL0|rcsb pdb:5AYT|rcsb pdb:5BOJ|rcsb pdb:5CLX|rcsb pdb:5CLY|rcsb pdb:5CLZ|rcsb pdb:5CM1|rcsb pdb:5AL8|rcsb pdb:5CN3|rcsb pdb:5CNH|rcsb pdb:5CR1|rcsb pdb:5DEJ|rcsb pdb:5DWP|rcsb pdb:5E23|rcsb pdb:5E4A|rcsb pdb:5E4O|rcsb pdb:5EN3|rcsb pdb:5EZP|rcsb pdb:5FO2|rcsb pdb:5FW6|rcsb pdb:5FW7|rcsb pdb:5FW8|rcsb pdb:5H0V|rcsb pdb:5H0W|rcsb pdb:5H0X|rcsb pdb:5H0Y|rcsb pdb:5H0Z|rcsb pdb:5HJG|rcsb pdb:5IHH|rcsb pdb:5JID|rcsb pdb:5JIM|rcsb pdb:5JIQ|rcsb pdb:5K1J|rcsb pdb:5K1N|rcsb pdb:5L4F|rcsb pdb:5L4I|rcsb pdb:5L4M|rcsb pdb:5LLL|rcsb pdb:5LLV|rcsb pdb:5N5Q|rcsb pdb:5N62|rcsb pdb:5N7C|rcsb pdb:5NFE|rcsb pdb:5NFW|rcsb pdb:5OQ0|rcsb pdb:5TTR|rcsb pdb:5TZL|rcsb pdb:5U48|rcsb pdb:5U49|rcsb pdb:5U4A|rcsb pdb:5U4B|rcsb pdb:5U4C|rcsb pdb:5U4D|rcsb pdb:5U4E|rcsb pdb:5U4F|rcsb pdb:5U4G|rcsb pdb:6D0W|rcsb pdb:6E6Z|rcsb pdb:6E70|rcsb pdb:6E71|rcsb pdb:5L4J|rcsb pdb:6E72|rcsb pdb:6E73|rcsb pdb:6E74|rcsb pdb:6E75|rcsb pdb:6E76|rcsb pdb:6E77|rcsb pdb:6E78|rcsb pdb:6EP1|rcsb pdb:6FFT|rcsb pdb:6FWD|rcsb pdb:6FXU|rcsb pdb:6FZL|rcsb pdb:6GR7|rcsb pdb:6GRP|rcsb pdb:6IMX|rcsb pdb:6IMY|rcsb pdb:6KGB|rcsb pdb:6R66|rcsb pdb:6R67|rcsb pdb:6R68|rcsb pdb:6R6I|rcsb pdb:6SDZ|rcsb pdb:6SUG|rcsb pdb:6SUH|rcsb pdb:6TI9|rcsb pdb:6TJN|rcsb pdb:6TXV|rcsb pdb:6TXW|rcsb pdb:6U0Q|rcsb pdb:6XTK|rcsb pdb:7ACU|reactome:R-HSA-2453864|reactome:R-HSA-2453902|reactome:R-HSA-3000171|reactome:R-HSA-6798695|reactome:R-HSA-975634|reactome:R-HSA-977225|ensembl:ENST00000237014(transcript)|ensembl:ENST00000649620(transcript)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006144"(purine nucleobase metabolic process)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042572"(retinol metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070324"(thyroid hormone binding)|go:"GO:0070327"(thyroid hormone transport)|interpro:IPR000895(Transthyretin)|interpro:IPR023416|interpro:IPR023418|interpro:IPR023419|interpro:IPR030178|interpro:IPR036817|mint:P02766|rcsb pdb:1BM7|rcsb pdb:1BMZ|rcsb pdb:1BZ8|rcsb pdb:1BZD|rcsb pdb:1BZE|rcsb pdb:1DVQ|rcsb pdb:1DVS|rcsb pdb:1DVT|rcsb pdb:1DVU|rcsb pdb:1DVX|rcsb pdb:1DVY|rcsb pdb:1DVZ|rcsb pdb:1E3F|rcsb pdb:1E4H|ensembl:ENSG00000118271(gene)|rcsb pdb:1E5A|rcsb pdb:1ETA|rcsb pdb:1ETB|rcsb pdb:1F41|rcsb pdb:1F64|rcsb pdb:1F86|rcsb pdb:1FH2|rcsb pdb:1FHN|rcsb pdb:1G1O|rcsb pdb:1GKO|rcsb pdb:1ICT|rcsb pdb:1III|rcsb pdb:1IIK|rcsb pdb:1IJN|rcsb pdb:1QAB|rcsb pdb:1QWH|rcsb pdb:1RLB|rcsb pdb:1SOK|rcsb pdb:1SOQ|rcsb pdb:1THA|rcsb pdb:1THC|rcsb pdb:1TLM|rcsb pdb:1TSH|rcsb pdb:1TT6|rcsb pdb:1TTA|rcsb pdb:1TTB|rcsb pdb:2F7I|rcsb pdb:2F8I|rcsb pdb:2FBR|rcsb pdb:2FLM|rcsb pdb:1TTC|rcsb pdb:2G3X|rcsb pdb:2G3Z|rcsb pdb:2G4E|rcsb pdb:2G4G|rcsb pdb:2G5U|rcsb pdb:2G9K|rcsb pdb:2GAB|rcsb pdb:2H4E|rcsb pdb:2M5N|rcsb pdb:2NBO|rcsb pdb:2NBP|rcsb pdb:2NOY|rcsb pdb:2PAB|rcsb pdb:2QEL|rcsb pdb:2QGB|rcsb pdb:2QGC|rcsb pdb:2QGD|rcsb pdb:1TTR|rcsb pdb:1TYR|rcsb pdb:1TZ8|rcsb pdb:1U21|rcsb pdb:2QGE|rcsb pdb:2ROX|rcsb pdb:2ROY|rcsb pdb:2TRH|rcsb pdb:2TRY|rcsb pdb:2WQA|rcsb pdb:3A4D|rcsb pdb:3A4E|rcsb pdb:3A4F|rcsb pdb:3B56|rcsb pdb:3BSZ|rcsb pdb:3BT0|rcsb pdb:3CBR|rcsb pdb:3CFM|rcsb pdb:3CFN|rcsb pdb:1X7S|rcsb pdb:1X7T|rcsb pdb:3CFQ|rcsb pdb:3CFT|rcsb pdb:3CN0|rcsb pdb:3CN1|rcsb pdb:3CN2|rcsb pdb:3CN3|rcsb pdb:3CN4|rcsb pdb:3CXF|rcsb pdb:3D2T|rcsb pdb:3D7P|rcsb pdb:3DGD|rcsb pdb:3DID|rcsb pdb:1Y1D|rcsb pdb:1Z7J|rcsb pdb:1ZCR|rcsb pdb:1ZD6|rcsb pdb:2B14|rcsb pdb:2B15|rcsb pdb:2B16|rcsb pdb:2B77|rcsb pdb:2B9A|rcsb pdb:3DJR|rcsb pdb:3DJS|rcsb pdb:3DJT|rcsb pdb:3DJZ|rcsb pdb:3DK0|rcsb pdb:3DK2|rcsb pdb:3DO4|rcsb pdb:3ESN|rcsb pdb:3ESO|rcsb pdb:3ESP|rcsb pdb:3FC8|refseq:NP_000362.1|dip:DIP-1083N|mint:MINT-7905840(identity)	-	comment:mint	-	comment:homomint|comment:mint|figure legend:no f|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2010/06/16	2014/10/16	rogid:boXnLIFfdXqcbPDK1gECwC+g7OM9606	rogid:VwPs2NgicC89f7Ehgf4d6uE9DuU9606	intact-crc:B144B6978810C91F|rigid:T1gKkRAaZeuL8ek0gChY5r23GJg	false	fusion protein:?-?(MINT-7905850)	fusion protein:?-?(MINT-7905846)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25713	uniprotkb:P02766	intact:EBI-8084264|intact:MINT-7905812|uniprotkb:Q2V574|ensembl:ENSP00000200691	intact:EBI-711909|ensembl:ENSP00000237014|ensembl:ENSP00000497927|uniprotkb:Q6IB96|uniprotkb:Q9UBZ6|uniprotkb:Q9UCM9|uniprotkb:Q549C7	psi-mi:mt3_human(display_long)|uniprotkb:MT3(gene name)|psi-mi:MT3(display_short)|uniprotkb:Metallothionein-III(gene name synonym)|uniprotkb:Growth inhibitory factor(gene name synonym)|uniprotkb:GIFB(gene name synonym)	psi-mi:tthy_human(display_long)|uniprotkb:Prealbumin(gene name synonym)|uniprotkb:TBPA(gene name synonym)|uniprotkb:ATTR(gene name synonym)|uniprotkb:TTR(gene name)|psi-mi:TTR(display_short)|uniprotkb:PALB(gene name synonym)	psi-mi:"MI:0440"(saturation binding)	Martinho et al. (2010)	pubmed:20646067|imex:IM-15603|mint:MINT-7905802|doi:10.1111/j.1742-4658.2010.07749	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8084352|mint:MINT-7905857|imex:IM-15603-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005945.1|go:"GO:0032095"(regulation of response to food)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044242"(cellular lipid catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055073"(cadmium ion homeostasis)|go:"GO:0060049"(regulation of protein glycosylation)|go:"GO:0060547"(negative regulation of necrotic cell death)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071294"(cellular response to zinc ion)|ensembl:ENSG00000087250(gene)|ensembl:ENST00000200691(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005507"(copper ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006707"(cholesterol catabolic process)|go:"GO:0006829"(zinc ion transport)|go:"GO:0006875"(cellular metal ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097214"(positive regulation of lysosomal membrane permeability)|go:"GO:0097450"(astrocyte end-foot)|go:"GO:2000117"(negative regulation of cysteine-type endopeptidase activity)|go:"GO:2000296"(negative regulation of hydrogen peroxide catabolic process)|go:"GO:2000376"(positive regulation of oxygen metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000006(Metallothionein, vertebrate)|interpro:IPR003019(Metallothionein superfamily, eukaryotic)|interpro:IPR017854(Metallothionein superfamily)|interpro:IPR018064|interpro:IPR023587|mint:P25713|rcsb pdb:2F5H|rcsb pdb:2FJ4|rcsb pdb:2FJ5|reactome:R-HSA-5661231|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016209"(antioxidant activity)|go:"GO:0016234"(inclusion body)|go:"GO:0016570"(histone modification)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|mint:MINT-7905860(identity)	rcsb pdb:3GLZ|rcsb pdb:3GPS|rcsb pdb:3GRB|rcsb pdb:3GRG|rcsb pdb:3GS0|rcsb pdb:3GS4|rcsb pdb:3GS7|rcsb pdb:3HJ0|rcsb pdb:3I9A|rcsb pdb:3I9I|rcsb pdb:3I9P|rcsb pdb:3IMR|rcsb pdb:3IMS|rcsb pdb:3IMT|rcsb pdb:3IMU|rcsb pdb:3IMV|rcsb pdb:3IMW|rcsb pdb:3IPB|rcsb pdb:3IPE|rcsb pdb:3KGS|rcsb pdb:3KGT|rcsb pdb:3KGU|rcsb pdb:3M1O|rcsb pdb:3NEE|rcsb pdb:3NEO|rcsb pdb:3NES|rcsb pdb:3NEX|rcsb pdb:3NG5|rcsb pdb:3OZK|rcsb pdb:3OZL|rcsb pdb:3FCB|rcsb pdb:3P3R|rcsb pdb:3P3S|rcsb pdb:3P3T|rcsb pdb:3P3U|rcsb pdb:3SSG|rcsb pdb:3TCT|rcsb pdb:3TFB|rcsb pdb:3U2I|rcsb pdb:3U2J|rcsb pdb:3W3B|rcsb pdb:4ABQ|rcsb pdb:4ABU|rcsb pdb:4ABV|rcsb pdb:4ABW|rcsb pdb:4AC2|rcsb pdb:4AC4|rcsb pdb:4ACT|rcsb pdb:4ANK|rcsb pdb:4D7B|rcsb pdb:4DER|rcsb pdb:4DES|rcsb pdb:4DET|rcsb pdb:4DEU|rcsb pdb:4DEW|rcsb pdb:4FI6|rcsb pdb:4FI7|rcsb pdb:4FI8|rcsb pdb:4HIQ|rcsb pdb:4HIS|rcsb pdb:4HJS|rcsb pdb:4HJT|rcsb pdb:4HJU|rcsb pdb:4I85|rcsb pdb:4I87|rcsb pdb:4IIZ|rcsb pdb:4IK6|rcsb pdb:4IK7|rcsb pdb:4IKI|rcsb pdb:4IKJ|rcsb pdb:4IKK|rcsb pdb:4IKL|rcsb pdb:4KY2|rcsb pdb:4L1S|rcsb pdb:4L1T|rcsb pdb:4MAS|rcsb pdb:4MRB|rcsb pdb:4MRC|rcsb pdb:4N85|rcsb pdb:4N86|rcsb pdb:4N87|rcsb pdb:4PM1|rcsb pdb:4PME|rcsb pdb:4PMF|rcsb pdb:4PVL|rcsb pdb:4PVM|rcsb pdb:4PVN|rcsb pdb:4I89|rcsb pdb:4PWE|rcsb pdb:4PWF|rcsb pdb:4PWG|rcsb pdb:4TLK|rcsb pdb:4TLS|rcsb pdb:4TLT|rcsb pdb:4TLU|rcsb pdb:4TM9|rcsb pdb:4TNE|rcsb pdb:4PWH|rcsb pdb:4TNF|rcsb pdb:4TNG|rcsb pdb:4TQ8|rcsb pdb:4TQH|rcsb pdb:4TQI|rcsb pdb:4TQP|rcsb pdb:4PWI|rcsb pdb:4PWJ|rcsb pdb:4PWK|rcsb pdb:4QRF|rcsb pdb:4WNJ|rcsb pdb:4WNS|rcsb pdb:4QXV|rcsb pdb:4QYA|rcsb pdb:4WO0|rcsb pdb:4TKW|rcsb pdb:4TL4|rcsb pdb:4TL5|rcsb pdb:4Y9B|rcsb pdb:4Y9C|rcsb pdb:4Y9E|rcsb pdb:4Y9F|rcsb pdb:4Y9G|rcsb pdb:4YDM|rcsb pdb:4YDN|rcsb pdb:5A6I|rcsb pdb:5AKS|rcsb pdb:5AKT|rcsb pdb:5AKV|rcsb pdb:5AL0|rcsb pdb:5AYT|rcsb pdb:5BOJ|rcsb pdb:5CLX|rcsb pdb:5CLY|rcsb pdb:5CLZ|rcsb pdb:5CM1|rcsb pdb:5AL8|rcsb pdb:5CN3|rcsb pdb:5CNH|rcsb pdb:5CR1|rcsb pdb:5DEJ|rcsb pdb:5DWP|rcsb pdb:5E23|rcsb pdb:5E4A|rcsb pdb:5E4O|rcsb pdb:5EN3|rcsb pdb:5EZP|rcsb pdb:5FO2|rcsb pdb:5FW6|rcsb pdb:5FW7|rcsb pdb:5FW8|rcsb pdb:5H0V|rcsb pdb:5H0W|rcsb pdb:5H0X|rcsb pdb:5H0Y|rcsb pdb:5H0Z|rcsb pdb:5HJG|rcsb pdb:5IHH|rcsb pdb:5JID|rcsb pdb:5JIM|rcsb pdb:5JIQ|rcsb pdb:5K1J|rcsb pdb:5K1N|rcsb pdb:5L4F|rcsb pdb:5L4I|rcsb pdb:5L4M|rcsb pdb:5LLL|rcsb pdb:5LLV|rcsb pdb:5N5Q|rcsb pdb:5N62|rcsb pdb:5N7C|rcsb pdb:5NFE|rcsb pdb:5NFW|rcsb pdb:5OQ0|rcsb pdb:5TTR|rcsb pdb:5TZL|rcsb pdb:5U48|rcsb pdb:5U49|rcsb pdb:5U4A|rcsb pdb:5U4B|rcsb pdb:5U4C|rcsb pdb:5U4D|rcsb pdb:5U4E|rcsb pdb:5U4F|rcsb pdb:5U4G|rcsb pdb:6D0W|rcsb pdb:6E6Z|rcsb pdb:6E70|rcsb pdb:6E71|rcsb pdb:5L4J|rcsb pdb:6E72|rcsb pdb:6E73|rcsb pdb:6E74|rcsb pdb:6E75|rcsb pdb:6E76|rcsb pdb:6E77|rcsb pdb:6E78|rcsb pdb:6EP1|rcsb pdb:6FFT|rcsb pdb:6FWD|rcsb pdb:6FXU|rcsb pdb:6FZL|rcsb pdb:6GR7|rcsb pdb:6GRP|rcsb pdb:6IMX|rcsb pdb:6IMY|rcsb pdb:6KGB|rcsb pdb:6R66|rcsb pdb:6R67|rcsb pdb:6R68|rcsb pdb:6R6I|rcsb pdb:6SDZ|rcsb pdb:6SUG|rcsb pdb:6SUH|rcsb pdb:6TI9|rcsb pdb:6TJN|rcsb pdb:6TXV|rcsb pdb:6TXW|rcsb pdb:6U0Q|rcsb pdb:6XTK|rcsb pdb:7ACU|reactome:R-HSA-2453864|reactome:R-HSA-2453902|reactome:R-HSA-3000171|reactome:R-HSA-6798695|reactome:R-HSA-975634|reactome:R-HSA-977225|ensembl:ENST00000237014(transcript)|ensembl:ENST00000649620(transcript)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006144"(purine nucleobase metabolic process)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042572"(retinol metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070324"(thyroid hormone binding)|go:"GO:0070327"(thyroid hormone transport)|interpro:IPR000895(Transthyretin)|interpro:IPR023416|interpro:IPR023418|interpro:IPR023419|interpro:IPR030178|interpro:IPR036817|mint:P02766|rcsb pdb:1BM7|rcsb pdb:1BMZ|rcsb pdb:1BZ8|rcsb pdb:1BZD|rcsb pdb:1BZE|rcsb pdb:1DVQ|rcsb pdb:1DVS|rcsb pdb:1DVT|rcsb pdb:1DVU|rcsb pdb:1DVX|rcsb pdb:1DVY|rcsb pdb:1DVZ|rcsb pdb:1E3F|rcsb pdb:1E4H|ensembl:ENSG00000118271(gene)|rcsb pdb:1E5A|rcsb pdb:1ETA|rcsb pdb:1ETB|rcsb pdb:1F41|rcsb pdb:1F64|rcsb pdb:1F86|rcsb pdb:1FH2|rcsb pdb:1FHN|rcsb pdb:1G1O|rcsb pdb:1GKO|rcsb pdb:1ICT|rcsb pdb:1III|rcsb pdb:1IIK|rcsb pdb:1IJN|rcsb pdb:1QAB|rcsb pdb:1QWH|rcsb pdb:1RLB|rcsb pdb:1SOK|rcsb pdb:1SOQ|rcsb pdb:1THA|rcsb pdb:1THC|rcsb pdb:1TLM|rcsb pdb:1TSH|rcsb pdb:1TT6|rcsb pdb:1TTA|rcsb pdb:1TTB|rcsb pdb:2F7I|rcsb pdb:2F8I|rcsb pdb:2FBR|rcsb pdb:2FLM|rcsb pdb:1TTC|rcsb pdb:2G3X|rcsb pdb:2G3Z|rcsb pdb:2G4E|rcsb pdb:2G4G|rcsb pdb:2G5U|rcsb pdb:2G9K|rcsb pdb:2GAB|rcsb pdb:2H4E|rcsb pdb:2M5N|rcsb pdb:2NBO|rcsb pdb:2NBP|rcsb pdb:2NOY|rcsb pdb:2PAB|rcsb pdb:2QEL|rcsb pdb:2QGB|rcsb pdb:2QGC|rcsb pdb:2QGD|rcsb pdb:1TTR|rcsb pdb:1TYR|rcsb pdb:1TZ8|rcsb pdb:1U21|rcsb pdb:2QGE|rcsb pdb:2ROX|rcsb pdb:2ROY|rcsb pdb:2TRH|rcsb pdb:2TRY|rcsb pdb:2WQA|rcsb pdb:3A4D|rcsb pdb:3A4E|rcsb pdb:3A4F|rcsb pdb:3B56|rcsb pdb:3BSZ|rcsb pdb:3BT0|rcsb pdb:3CBR|rcsb pdb:3CFM|rcsb pdb:3CFN|rcsb pdb:1X7S|rcsb pdb:1X7T|rcsb pdb:3CFQ|rcsb pdb:3CFT|rcsb pdb:3CN0|rcsb pdb:3CN1|rcsb pdb:3CN2|rcsb pdb:3CN3|rcsb pdb:3CN4|rcsb pdb:3CXF|rcsb pdb:3D2T|rcsb pdb:3D7P|rcsb pdb:3DGD|rcsb pdb:3DID|rcsb pdb:1Y1D|rcsb pdb:1Z7J|rcsb pdb:1ZCR|rcsb pdb:1ZD6|rcsb pdb:2B14|rcsb pdb:2B15|rcsb pdb:2B16|rcsb pdb:2B77|rcsb pdb:2B9A|rcsb pdb:3DJR|rcsb pdb:3DJS|rcsb pdb:3DJT|rcsb pdb:3DJZ|rcsb pdb:3DK0|rcsb pdb:3DK2|rcsb pdb:3DO4|rcsb pdb:3ESN|rcsb pdb:3ESO|rcsb pdb:3ESP|rcsb pdb:3FC8|refseq:NP_000362.1|dip:DIP-1083N|mint:MINT-7905859(identity)	-	comment:mint	-	figure legend:f1|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:373.7x10^-9(molar)	2010/06/16	2014/10/16	rogid:boXnLIFfdXqcbPDK1gECwC+g7OM9606	rogid:VwPs2NgicC89f7Ehgf4d6uE9DuU9606	intact-crc:6DB4659C2A981ECE|rigid:T1gKkRAaZeuL8ek0gChY5r23GJg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02767	uniprotkb:P05067	intact:EBI-6675014|ensembl:ENSRNOP00000022113|uniprotkb:Q547K9	intact:EBI-77613|uniprotkb:P09000|uniprotkb:P78438|uniprotkb:Q13764|uniprotkb:Q13778|uniprotkb:Q13793|ensembl:ENSP00000284981|intact:EBI-28985182|uniprotkb:Q6GSC0|uniprotkb:Q8WZ99|uniprotkb:Q9UC33|uniprotkb:Q9UCC8|uniprotkb:Q9UCD1|uniprotkb:Q9UQ58|uniprotkb:Q16011|uniprotkb:Q16014|uniprotkb:Q16019|uniprotkb:Q16020|uniprotkb:Q9BT38|uniprotkb:Q9UCA9|uniprotkb:Q9UCB6|uniprotkb:B4DII8|uniprotkb:B2R5V1|uniprotkb:D3DSD1|uniprotkb:D3DSD2|uniprotkb:D3DSD3	psi-mi:tthy_rat(display_long)|uniprotkb:Ttr(gene name)|psi-mi:Ttr(display_short)|uniprotkb:Tt(gene name synonym)|uniprotkb:Prealbumin(gene name synonym)|uniprotkb:TBPA(gene name synonym)	psi-mi:a4_human(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)	psi-mi:"MI:0440"(saturation binding)	Martinho et al. (2010)	pubmed:20646067|imex:IM-15603|mint:MINT-7905802|doi:10.1111/j.1742-4658.2010.07749	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8084365|mint:MINT-7905930|imex:IM-15603-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000016275(gene)|ensembl:ENSRNOT00000022113(transcript)|go:"GO:0005179"(hormone activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006144"(purine nucleobase metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042403"(thyroid hormone metabolic process)|go:"GO:0042562"(hormone binding)|go:"GO:0042572"(retinol metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070324"(thyroid hormone binding)|go:"GO:0070327"(thyroid hormone transport)|interpro:IPR000895(Transthyretin)|interpro:IPR023416|interpro:IPR023418|interpro:IPR023419|interpro:IPR030178|interpro:IPR036817|mint:P02767|rcsb pdb:1GKE|rcsb pdb:1IE4|rcsb pdb:1KGI|rcsb pdb:1KGJ|rcsb pdb:1RVS|rcsb pdb:2M5K|rcsb pdb:2M5M|rcsb pdb:3ZPK|reactome:R-RNO-2453902|reactome:R-RNO-3000171|reactome:R-RNO-6798695|reactome:R-RNO-975634|refseq:XP_006254519.1|refseq:NP_036813.2|rgd:3916|mint:MINT-7905933(identity)	go:"GO:0097645"(amylin binding)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0106003"(amyloid-beta complex)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:1900122"(positive regulation of receptor binding)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903048"(regulation of acetylcholine-gated cation channel activity)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904022"(positive regulation of G protein-coupled receptor internalization)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044304"(main axon)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|ensembl:ENST00000346798(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSG00000142192(gene)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001878"(response to yeast)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001967"(suckling behavior)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007155"(cell adhesion)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0006897"(endocytosis)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007617"(mating behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0008201"(heparin binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0009987"(cellular process)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048669"(collateral sprouting in absence of injury)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050808"(synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050867"(positive regulation of cell activation)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050890"(cognition)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051124"(synaptic assembly at neuromuscular junction)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014005"(microglia development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016358"(dendrite development)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019899"(enzyme binding)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030424"(axon)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0030549"(acetylcholine receptor activator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0031904"(endosome lumen)|go:"GO:0051233"(spindle midzone)|go:"GO:0061903"(positive regulation of 1-phosphatidylinositol-3-kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071874"(cellular response to norepinephrine stimulus)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097449"(astrocyte projection)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051563"(smooth endoplasmic reticulum calcium ion homeostasis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:1904399"(heparan sulfate binding)|rcsb pdb:2LZ4|rcsb pdb:2M4J|rcsb pdb:2M9R|rcsb pdb:2M9S|rcsb pdb:2MGT|rcsb pdb:2MJ1|rcsb pdb:2MPZ|rcsb pdb:2MVX|rcsb pdb:2MXU|rcsb pdb:2NAO|interpro:IPR036880|interpro:IPR037071|rcsb pdb:2OTK|rcsb pdb:2R0W|rcsb pdb:2WK3|rcsb pdb:2Y29|mint:P05067|rcsb pdb:1AAP|rcsb pdb:1AMB|rcsb pdb:1AMC|rcsb pdb:1AML|rcsb pdb:1BA4|rcsb pdb:1BA6|rcsb pdb:1BJB|rcsb pdb:1BJC|rcsb pdb:1BRC|rcsb pdb:1CA0|rcsb pdb:1HZ3|rcsb pdb:1IYT|rcsb pdb:1MWP|rcsb pdb:1OWT|rcsb pdb:1QCM|rcsb pdb:1QWP|rcsb pdb:1QXC|rcsb pdb:1QYT|rcsb pdb:1TAW|rcsb pdb:1TKN|rcsb pdb:1UO7|rcsb pdb:1UO8|rcsb pdb:1UOA|rcsb pdb:1UOI|rcsb pdb:1X11|rcsb pdb:1Z0Q|rcsb pdb:1ZE7|rcsb pdb:1ZE9|rcsb pdb:1ZJD|rcsb pdb:2BEG|rcsb pdb:2BOM|rcsb pdb:2BP4|rcsb pdb:2FJZ|rcsb pdb:2FK1|rcsb pdb:2FK2|rcsb pdb:2FK3|rcsb pdb:2FKL|rcsb pdb:2FMA|rcsb pdb:2G47|rcsb pdb:2IPU|rcsb pdb:2LFM|rcsb pdb:2LLM|rcsb pdb:2LMN|rcsb pdb:2LMO|rcsb pdb:2LMP|rcsb pdb:2LMQ|rcsb pdb:2LNQ|rcsb pdb:2LOH|rcsb pdb:2LP1|rcsb pdb:2LZ3|rcsb pdb:2Y2A|rcsb pdb:2Y3J|rcsb pdb:2Y3K|rcsb pdb:2Y3L|rcsb pdb:3AYU|rcsb pdb:3BAE|rcsb pdb:3BKJ|rcsb pdb:3DXC|rcsb pdb:3DXD|rcsb pdb:3DXE|rcsb pdb:3GCI|rcsb pdb:3IFL|rcsb pdb:3IFN|rcsb pdb:3IFO|rcsb pdb:3IFP|rcsb pdb:3JQ5|rcsb pdb:3JQL|rcsb pdb:3JTI|rcsb pdb:3KTM|rcsb pdb:3L33|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904591"(positive regulation of protein import)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1905893"(positive regulation of cellular response to thapsigargin)|go:"GO:1905896"(positive regulation of cellular response to tunicamycin)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1905945"(regulation of response to calcium ion)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:1990761"(growth cone lamellipodium)|go:"GO:1990777"(lipoprotein particle)|go:"GO:1990812"(growth cone filopodium)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR008154(Amyloidogenic glycoprotein, extracellular)|interpro:IPR008155(Amyloidogenic glycoprotein, core)|interpro:IPR011178(Amyloidogenic glycoprotein, copper-binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013803(Amyloidogenic glycoprotein, amyloid-beta peptide)|interpro:IPR015849(Amyloidogenic glycoprotein, heparin-binding)|interpro:IPR019543|interpro:IPR019744|interpro:IPR019745|interpro:IPR020901|interpro:IPR024329|interpro:IPR028866|interpro:IPR036176|interpro:IPR036454|interpro:IPR036669|rcsb pdb:5HOY|rcsb pdb:5KK3|rcsb pdb:5LFY|rcsb pdb:5LV0|rcsb pdb:5MY4|rcsb pdb:5MYO|rcsb pdb:5MYX|rcsb pdb:5ONP|rcsb pdb:5ONQ|rcsb pdb:5OQV|rcsb pdb:5TXD|rcsb pdb:5VOS|rcsb pdb:5VZY|rcsb pdb:5W3P|rcsb pdb:6CO3|rcsb pdb:6GFI|rcsb pdb:6ITU|rcsb pdb:6IYC|rcsb pdb:6NB9|rcsb pdb:6O4J|rcsb pdb:6OC9|rcsb pdb:6OIZ|rcsb pdb:6RHY|rcsb pdb:6SHS|rcsb pdb:6SZF|rcsb pdb:6TI5|rcsb pdb:6TI6|rcsb pdb:6TI7|rcsb pdb:6W0O|rcsb pdb:6WXM|rcsb pdb:6YHF|rcsb pdb:6YHI|rcsb pdb:6YHO|rcsb pdb:6YHP|rcsb pdb:6YHX|rcsb pdb:7B3J|rcsb pdb:7B3K|rcsb pdb:7JXN|rcsb pdb:7JXO|rcsb pdb:7O1Q|reactome:R-HSA-114608|reactome:R-HSA-3000178|reactome:R-HSA-381426|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-432720|reactome:R-HSA-444473|reactome:R-HSA-445989|reactome:R-HSA-844456|reactome:R-HSA-879415|reactome:R-HSA-8862803|reactome:R-HSA-8957275|reactome:R-HSA-933542|reactome:R-HSA-9609523|reactome:R-HSA-9660826|reactome:R-HSA-977225|rcsb pdb:5AMB|rcsb pdb:5BUO|rcsb pdb:5C67|rcsb pdb:5CSZ|rcsb pdb:5HOW|rcsb pdb:5HOX|rcsb pdb:3L81|rcsb pdb:3MOQ|rcsb pdb:3MXC|rcsb pdb:3MXY|rcsb pdb:3NYJ|rcsb pdb:3NYL|rcsb pdb:3OVJ|rcsb pdb:3OW9|rcsb pdb:3PZZ|rcsb pdb:3Q2X|rcsb pdb:3SV1|rcsb pdb:3U0T|rcsb pdb:3UMH|rcsb pdb:3UMI|rcsb pdb:3UMK|rcsb pdb:4HIX|rcsb pdb:4JFN|rcsb pdb:4M1C|rcsb pdb:4MDR|rcsb pdb:4MVI|rcsb pdb:4MVK|rcsb pdb:4MVL|rcsb pdb:4NGE|rcsb pdb:4OJF|rcsb pdb:4ONF|rcsb pdb:4ONG|rcsb pdb:4PQD|rcsb pdb:4PWQ|rcsb pdb:4XXD|rcsb pdb:5AEF|rcsb pdb:5AM8|refseq:NP_000475.1|refseq:NP_001129601.1|refseq:NP_001129602.1|refseq:NP_001191230.1|refseq:NP_001191231.1|refseq:NP_001191232.1|refseq:NP_958816.1|refseq:NP_958817.1|ensembl:ENSP00000284981|ensembl:ENST00000348990|ensembl:ENSP00000345463|ensembl:ENST00000354192|ensembl:ENSP00000346129|ensembl:ENST00000357903|ensembl:ENSP00000350578|ensembl:ENST00000358918|ensembl:ENSP00000351796|ensembl:ENST00000440126|ensembl:ENSP00000387483|refseq:NP_001129488.1|refseq:NP_001129603.1|dip:DIP-574N|mint:MINT-7905932(identity)	-	-	-	figure legend:f4|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/16	2014/10/16	rogid:36h5MG2Ta1EfNQcgB1d8+GneH4810116	rogid:HatR8w8+mNjtjr7s5+bAwaStpmk9606	intact-crc:255EB4DB0F1002FD|rigid:7amFsL+mKxKmxroFRdoxVxxh+bU	false	-	binding-associated region:1-42(MINT-7905936)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02767	uniprotkb:P37361	intact:EBI-6675014|ensembl:ENSRNOP00000022113|uniprotkb:Q547K9	intact:EBI-1374524|ensembl:ENSRNOP00000025669	psi-mi:tthy_rat(display_long)|uniprotkb:Ttr(gene name)|psi-mi:Ttr(display_short)|uniprotkb:Tt(gene name synonym)|uniprotkb:Prealbumin(gene name synonym)|uniprotkb:TBPA(gene name synonym)	psi-mi:mt3_rat(display_long)|uniprotkb:Mt3(gene name)|psi-mi:Mt3(display_short)|uniprotkb:Metallothionein-III(gene name synonym)|uniprotkb:Growth inhibitory factor(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Martinho et al. (2010)	pubmed:20646067|imex:IM-15603|mint:MINT-7905802|doi:10.1111/j.1742-4658.2010.07749	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8084407|mint:MINT-7905895|imex:IM-15603-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000016275(gene)|ensembl:ENSRNOT00000022113(transcript)|go:"GO:0005179"(hormone activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006144"(purine nucleobase metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042403"(thyroid hormone metabolic process)|go:"GO:0042562"(hormone binding)|go:"GO:0042572"(retinol metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070324"(thyroid hormone binding)|go:"GO:0070327"(thyroid hormone transport)|interpro:IPR000895(Transthyretin)|interpro:IPR023416|interpro:IPR023418|interpro:IPR023419|interpro:IPR030178|interpro:IPR036817|mint:P02767|rcsb pdb:1GKE|rcsb pdb:1IE4|rcsb pdb:1KGI|rcsb pdb:1KGJ|rcsb pdb:1RVS|rcsb pdb:2M5K|rcsb pdb:2M5M|rcsb pdb:3ZPK|reactome:R-RNO-2453902|reactome:R-RNO-3000171|reactome:R-RNO-6798695|reactome:R-RNO-975634|refseq:XP_006254519.1|refseq:NP_036813.2|rgd:3916|mint:MINT-7905897(identity)	rgd:621252|refseq:NP_446420.1|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055073"(cadmium ion homeostasis)|go:"GO:0060049"(regulation of protein glycosylation)|go:"GO:0060547"(negative regulation of necrotic cell death)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097214"(positive regulation of lysosomal membrane permeability)|go:"GO:0097449"(astrocyte projection)|go:"GO:0097450"(astrocyte end-foot)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:2000117"(negative regulation of cysteine-type endopeptidase activity)|go:"GO:2000296"(negative regulation of hydrogen peroxide catabolic process)|go:"GO:2000376"(positive regulation of oxygen metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000006(Metallothionein, vertebrate)|interpro:IPR003019(Metallothionein superfamily, eukaryotic)|interpro:IPR017854(Metallothionein superfamily)|interpro:IPR018064|interpro:IPR023587|mint:P37361|reactome:R-RNO-5661231|ensembl:ENSRNOG00000018958(gene)|ensembl:ENSRNOT00000025669(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005507"(copper ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005840"(ribosome)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006707"(cholesterol catabolic process)|go:"GO:0006829"(zinc ion transport)|go:"GO:0006875"(cellular metal ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014002"(astrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016234"(inclusion body)|go:"GO:0016570"(histone modification)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044242"(cellular lipid catabolic process)|mint:MINT-7905898(identity)	go:"GO:0005783"(endoplasmic reticulum)	-	-	figure legend:f2a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cpec)|taxid:10116(Rattus norvegicus)	-	2010/06/16	2014/10/16	rogid:36h5MG2Ta1EfNQcgB1d8+GneH4810116	rogid:CQUNi1gLHk512lc0gQl6i/7pft010116	intact-crc:1CDABCEEE4CE2F7A|rigid:DI1rBHc3unEvGWv8M0lHsqR45bQ	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P25713	uniprotkb:P02766	intact:EBI-8084264|intact:MINT-7905812|uniprotkb:Q2V574|ensembl:ENSP00000200691	intact:EBI-711909|ensembl:ENSP00000237014|ensembl:ENSP00000497927|uniprotkb:Q6IB96|uniprotkb:Q9UBZ6|uniprotkb:Q9UCM9|uniprotkb:Q549C7	psi-mi:mt3_human(display_long)|uniprotkb:MT3(gene name)|psi-mi:MT3(display_short)|uniprotkb:Metallothionein-III(gene name synonym)|uniprotkb:Growth inhibitory factor(gene name synonym)|uniprotkb:GIFB(gene name synonym)	psi-mi:tthy_human(display_long)|uniprotkb:Prealbumin(gene name synonym)|uniprotkb:TBPA(gene name synonym)|uniprotkb:ATTR(gene name synonym)|uniprotkb:TTR(gene name)|psi-mi:TTR(display_short)|uniprotkb:PALB(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Martinho et al. (2010)	pubmed:20646067|imex:IM-15603|mint:MINT-7905802|doi:10.1111/j.1742-4658.2010.07749	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8084429|mint:MINT-7905914|imex:IM-15603-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005945.1|go:"GO:0032095"(regulation of response to food)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044242"(cellular lipid catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055073"(cadmium ion homeostasis)|go:"GO:0060049"(regulation of protein glycosylation)|go:"GO:0060547"(negative regulation of necrotic cell death)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071294"(cellular response to zinc ion)|ensembl:ENSG00000087250(gene)|ensembl:ENST00000200691(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005507"(copper ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006707"(cholesterol catabolic process)|go:"GO:0006829"(zinc ion transport)|go:"GO:0006875"(cellular metal ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097214"(positive regulation of lysosomal membrane permeability)|go:"GO:0097450"(astrocyte end-foot)|go:"GO:2000117"(negative regulation of cysteine-type endopeptidase activity)|go:"GO:2000296"(negative regulation of hydrogen peroxide catabolic process)|go:"GO:2000376"(positive regulation of oxygen metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000006(Metallothionein, vertebrate)|interpro:IPR003019(Metallothionein superfamily, eukaryotic)|interpro:IPR017854(Metallothionein superfamily)|interpro:IPR018064|interpro:IPR023587|mint:P25713|rcsb pdb:2F5H|rcsb pdb:2FJ4|rcsb pdb:2FJ5|reactome:R-HSA-5661231|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016209"(antioxidant activity)|go:"GO:0016234"(inclusion body)|go:"GO:0016570"(histone modification)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|mint:MINT-7905916(identity)	rcsb pdb:3GLZ|rcsb pdb:3GPS|rcsb pdb:3GRB|rcsb pdb:3GRG|rcsb pdb:3GS0|rcsb pdb:3GS4|rcsb pdb:3GS7|rcsb pdb:3HJ0|rcsb pdb:3I9A|rcsb pdb:3I9I|rcsb pdb:3I9P|rcsb pdb:3IMR|rcsb pdb:3IMS|rcsb pdb:3IMT|rcsb pdb:3IMU|rcsb pdb:3IMV|rcsb pdb:3IMW|rcsb pdb:3IPB|rcsb pdb:3IPE|rcsb pdb:3KGS|rcsb pdb:3KGT|rcsb pdb:3KGU|rcsb pdb:3M1O|rcsb pdb:3NEE|rcsb pdb:3NEO|rcsb pdb:3NES|rcsb pdb:3NEX|rcsb pdb:3NG5|rcsb pdb:3OZK|rcsb pdb:3OZL|rcsb pdb:3FCB|rcsb pdb:3P3R|rcsb pdb:3P3S|rcsb pdb:3P3T|rcsb pdb:3P3U|rcsb pdb:3SSG|rcsb pdb:3TCT|rcsb pdb:3TFB|rcsb pdb:3U2I|rcsb pdb:3U2J|rcsb pdb:3W3B|rcsb pdb:4ABQ|rcsb pdb:4ABU|rcsb pdb:4ABV|rcsb pdb:4ABW|rcsb pdb:4AC2|rcsb pdb:4AC4|rcsb pdb:4ACT|rcsb pdb:4ANK|rcsb pdb:4D7B|rcsb pdb:4DER|rcsb pdb:4DES|rcsb pdb:4DET|rcsb pdb:4DEU|rcsb pdb:4DEW|rcsb pdb:4FI6|rcsb pdb:4FI7|rcsb pdb:4FI8|rcsb pdb:4HIQ|rcsb pdb:4HIS|rcsb pdb:4HJS|rcsb pdb:4HJT|rcsb pdb:4HJU|rcsb pdb:4I85|rcsb pdb:4I87|rcsb pdb:4IIZ|rcsb pdb:4IK6|rcsb pdb:4IK7|rcsb pdb:4IKI|rcsb pdb:4IKJ|rcsb pdb:4IKK|rcsb pdb:4IKL|rcsb pdb:4KY2|rcsb pdb:4L1S|rcsb pdb:4L1T|rcsb pdb:4MAS|rcsb pdb:4MRB|rcsb pdb:4MRC|rcsb pdb:4N85|rcsb pdb:4N86|rcsb pdb:4N87|rcsb pdb:4PM1|rcsb pdb:4PME|rcsb pdb:4PMF|rcsb pdb:4PVL|rcsb pdb:4PVM|rcsb pdb:4PVN|rcsb pdb:4I89|rcsb pdb:4PWE|rcsb pdb:4PWF|rcsb pdb:4PWG|rcsb pdb:4TLK|rcsb pdb:4TLS|rcsb pdb:4TLT|rcsb pdb:4TLU|rcsb pdb:4TM9|rcsb pdb:4TNE|rcsb pdb:4PWH|rcsb pdb:4TNF|rcsb pdb:4TNG|rcsb pdb:4TQ8|rcsb pdb:4TQH|rcsb pdb:4TQI|rcsb pdb:4TQP|rcsb pdb:4PWI|rcsb pdb:4PWJ|rcsb pdb:4PWK|rcsb pdb:4QRF|rcsb pdb:4WNJ|rcsb pdb:4WNS|rcsb pdb:4QXV|rcsb pdb:4QYA|rcsb pdb:4WO0|rcsb pdb:4TKW|rcsb pdb:4TL4|rcsb pdb:4TL5|rcsb pdb:4Y9B|rcsb pdb:4Y9C|rcsb pdb:4Y9E|rcsb pdb:4Y9F|rcsb pdb:4Y9G|rcsb pdb:4YDM|rcsb pdb:4YDN|rcsb pdb:5A6I|rcsb pdb:5AKS|rcsb pdb:5AKT|rcsb pdb:5AKV|rcsb pdb:5AL0|rcsb pdb:5AYT|rcsb pdb:5BOJ|rcsb pdb:5CLX|rcsb pdb:5CLY|rcsb pdb:5CLZ|rcsb pdb:5CM1|rcsb pdb:5AL8|rcsb pdb:5CN3|rcsb pdb:5CNH|rcsb pdb:5CR1|rcsb pdb:5DEJ|rcsb pdb:5DWP|rcsb pdb:5E23|rcsb pdb:5E4A|rcsb pdb:5E4O|rcsb pdb:5EN3|rcsb pdb:5EZP|rcsb pdb:5FO2|rcsb pdb:5FW6|rcsb pdb:5FW7|rcsb pdb:5FW8|rcsb pdb:5H0V|rcsb pdb:5H0W|rcsb pdb:5H0X|rcsb pdb:5H0Y|rcsb pdb:5H0Z|rcsb pdb:5HJG|rcsb pdb:5IHH|rcsb pdb:5JID|rcsb pdb:5JIM|rcsb pdb:5JIQ|rcsb pdb:5K1J|rcsb pdb:5K1N|rcsb pdb:5L4F|rcsb pdb:5L4I|rcsb pdb:5L4M|rcsb pdb:5LLL|rcsb pdb:5LLV|rcsb pdb:5N5Q|rcsb pdb:5N62|rcsb pdb:5N7C|rcsb pdb:5NFE|rcsb pdb:5NFW|rcsb pdb:5OQ0|rcsb pdb:5TTR|rcsb pdb:5TZL|rcsb pdb:5U48|rcsb pdb:5U49|rcsb pdb:5U4A|rcsb pdb:5U4B|rcsb pdb:5U4C|rcsb pdb:5U4D|rcsb pdb:5U4E|rcsb pdb:5U4F|rcsb pdb:5U4G|rcsb pdb:6D0W|rcsb pdb:6E6Z|rcsb pdb:6E70|rcsb pdb:6E71|rcsb pdb:5L4J|rcsb pdb:6E72|rcsb pdb:6E73|rcsb pdb:6E74|rcsb pdb:6E75|rcsb pdb:6E76|rcsb pdb:6E77|rcsb pdb:6E78|rcsb pdb:6EP1|rcsb pdb:6FFT|rcsb pdb:6FWD|rcsb pdb:6FXU|rcsb pdb:6FZL|rcsb pdb:6GR7|rcsb pdb:6GRP|rcsb pdb:6IMX|rcsb pdb:6IMY|rcsb pdb:6KGB|rcsb pdb:6R66|rcsb pdb:6R67|rcsb pdb:6R68|rcsb pdb:6R6I|rcsb pdb:6SDZ|rcsb pdb:6SUG|rcsb pdb:6SUH|rcsb pdb:6TI9|rcsb pdb:6TJN|rcsb pdb:6TXV|rcsb pdb:6TXW|rcsb pdb:6U0Q|rcsb pdb:6XTK|rcsb pdb:7ACU|reactome:R-HSA-2453864|reactome:R-HSA-2453902|reactome:R-HSA-3000171|reactome:R-HSA-6798695|reactome:R-HSA-975634|reactome:R-HSA-977225|ensembl:ENST00000237014(transcript)|ensembl:ENST00000649620(transcript)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006144"(purine nucleobase metabolic process)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042572"(retinol metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070324"(thyroid hormone binding)|go:"GO:0070327"(thyroid hormone transport)|interpro:IPR000895(Transthyretin)|interpro:IPR023416|interpro:IPR023418|interpro:IPR023419|interpro:IPR030178|interpro:IPR036817|mint:P02766|rcsb pdb:1BM7|rcsb pdb:1BMZ|rcsb pdb:1BZ8|rcsb pdb:1BZD|rcsb pdb:1BZE|rcsb pdb:1DVQ|rcsb pdb:1DVS|rcsb pdb:1DVT|rcsb pdb:1DVU|rcsb pdb:1DVX|rcsb pdb:1DVY|rcsb pdb:1DVZ|rcsb pdb:1E3F|rcsb pdb:1E4H|ensembl:ENSG00000118271(gene)|rcsb pdb:1E5A|rcsb pdb:1ETA|rcsb pdb:1ETB|rcsb pdb:1F41|rcsb pdb:1F64|rcsb pdb:1F86|rcsb pdb:1FH2|rcsb pdb:1FHN|rcsb pdb:1G1O|rcsb pdb:1GKO|rcsb pdb:1ICT|rcsb pdb:1III|rcsb pdb:1IIK|rcsb pdb:1IJN|rcsb pdb:1QAB|rcsb pdb:1QWH|rcsb pdb:1RLB|rcsb pdb:1SOK|rcsb pdb:1SOQ|rcsb pdb:1THA|rcsb pdb:1THC|rcsb pdb:1TLM|rcsb pdb:1TSH|rcsb pdb:1TT6|rcsb pdb:1TTA|rcsb pdb:1TTB|rcsb pdb:2F7I|rcsb pdb:2F8I|rcsb pdb:2FBR|rcsb pdb:2FLM|rcsb pdb:1TTC|rcsb pdb:2G3X|rcsb pdb:2G3Z|rcsb pdb:2G4E|rcsb pdb:2G4G|rcsb pdb:2G5U|rcsb pdb:2G9K|rcsb pdb:2GAB|rcsb pdb:2H4E|rcsb pdb:2M5N|rcsb pdb:2NBO|rcsb pdb:2NBP|rcsb pdb:2NOY|rcsb pdb:2PAB|rcsb pdb:2QEL|rcsb pdb:2QGB|rcsb pdb:2QGC|rcsb pdb:2QGD|rcsb pdb:1TTR|rcsb pdb:1TYR|rcsb pdb:1TZ8|rcsb pdb:1U21|rcsb pdb:2QGE|rcsb pdb:2ROX|rcsb pdb:2ROY|rcsb pdb:2TRH|rcsb pdb:2TRY|rcsb pdb:2WQA|rcsb pdb:3A4D|rcsb pdb:3A4E|rcsb pdb:3A4F|rcsb pdb:3B56|rcsb pdb:3BSZ|rcsb pdb:3BT0|rcsb pdb:3CBR|rcsb pdb:3CFM|rcsb pdb:3CFN|rcsb pdb:1X7S|rcsb pdb:1X7T|rcsb pdb:3CFQ|rcsb pdb:3CFT|rcsb pdb:3CN0|rcsb pdb:3CN1|rcsb pdb:3CN2|rcsb pdb:3CN3|rcsb pdb:3CN4|rcsb pdb:3CXF|rcsb pdb:3D2T|rcsb pdb:3D7P|rcsb pdb:3DGD|rcsb pdb:3DID|rcsb pdb:1Y1D|rcsb pdb:1Z7J|rcsb pdb:1ZCR|rcsb pdb:1ZD6|rcsb pdb:2B14|rcsb pdb:2B15|rcsb pdb:2B16|rcsb pdb:2B77|rcsb pdb:2B9A|rcsb pdb:3DJR|rcsb pdb:3DJS|rcsb pdb:3DJT|rcsb pdb:3DJZ|rcsb pdb:3DK0|rcsb pdb:3DK2|rcsb pdb:3DO4|rcsb pdb:3ESN|rcsb pdb:3ESO|rcsb pdb:3ESP|rcsb pdb:3FC8|refseq:NP_000362.1|dip:DIP-1083N|mint:MINT-7905917(identity)	-	comment:mint	-	figure legend:f3b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2010/06/16	2014/10/16	rogid:boXnLIFfdXqcbPDK1gECwC+g7OM9606	rogid:VwPs2NgicC89f7Ehgf4d6uE9DuU9606	intact-crc:135B540134C5BA9C|rigid:T1gKkRAaZeuL8ek0gChY5r23GJg	false	ha tag:?-?(MINT-7905923)	myc tag:?-?(MINT-7905919)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)