#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q61526	uniprotkb:P70424	intact:EBI-931878|uniprotkb:Q3KQR1|uniprotkb:Q68J64|uniprotkb:Q810U8|uniprotkb:Q8K317|ensembl:ENSMUSP00000080716	intact:EBI-2945468|ensembl:ENSMUSP00000053897|uniprotkb:Q61525|uniprotkb:Q6ZPE0	psi-mi:erbb3_mouse(display_long)|uniprotkb:Erbb3(gene name)|psi-mi:Erbb3(display_short)|uniprotkb:Glial growth factor receptor(gene name synonym)|uniprotkb:Proto-oncogene-like protein c-ErbB-3(gene name synonym)	psi-mi:erbb2_mouse(display_long)|uniprotkb:Erbb2(gene name)|psi-mi:Erbb2(display_short)|uniprotkb:Kiaa3023(gene name synonym)|uniprotkb:Neu(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:p185erbB2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakamoto et al. (2010)	pubmed:20639901|imex:IM-15181	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-2945516|imex:IM-15181-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034283.1|ensembl:ENSMUSG00000018166(gene)|ensembl:ENSMUST00000082059(transcript)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014037"(Schwann cell differentiation)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019838"(growth factor binding)|go:"GO:0021545"(cranial nerve development)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038131"(neuregulin receptor activity)|go:"GO:0038132"(neuregulin binding)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051048"(negative regulation of secretion)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0055025"(positive regulation of cardiac muscle tissue development)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|reactome:R-MMU-1358803	ensembl:ENSMUSG00000062312(gene)|ensembl:ENSMUST00000058295(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010008"(endosome membrane)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043219"(lateral loop)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048678"(response to axon injury)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|reactome:R-MMU-1227986|reactome:R-MMU-1250196|reactome:R-MMU-1257604|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-416572|reactome:R-MMU-5673001|reactome:R-MMU-6785631|reactome:R-MMU-6811558|reactome:R-MMU-8847993|reactome:R-MMU-8863795|reactome:R-MMU-9652282|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|refseq:NP_001003817.1|dip:DIP-40912N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6b|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mammary gland)|taxid:10090(Mus musculus mammary gland)	-	2010/11/18	2014/10/16	rogid:HFP4VR1PpgpvSVSKWkV5iDI8FF010090	rogid:+lOIwIPXJnyC0pwki4J6+7mk1+w10090	intact-crc:0D9FC59C31F1280A|rigid:valzWUuwkCoNmU1gdv5TAhB8CfQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61526	uniprotkb:P70424	intact:EBI-931878|uniprotkb:Q3KQR1|uniprotkb:Q68J64|uniprotkb:Q810U8|uniprotkb:Q8K317|ensembl:ENSMUSP00000080716	intact:EBI-2945468|ensembl:ENSMUSP00000053897|uniprotkb:Q61525|uniprotkb:Q6ZPE0	psi-mi:erbb3_mouse(display_long)|uniprotkb:Erbb3(gene name)|psi-mi:Erbb3(display_short)|uniprotkb:Glial growth factor receptor(gene name synonym)|uniprotkb:Proto-oncogene-like protein c-ErbB-3(gene name synonym)	psi-mi:erbb2_mouse(display_long)|uniprotkb:Erbb2(gene name)|psi-mi:Erbb2(display_short)|uniprotkb:Kiaa3023(gene name synonym)|uniprotkb:Neu(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:p185erbB2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sakamoto et al. (2010)	pubmed:20639901|imex:IM-15181	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-2945520|imex:IM-15181-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034283.1|ensembl:ENSMUSG00000018166(gene)|ensembl:ENSMUST00000082059(transcript)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014037"(Schwann cell differentiation)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019838"(growth factor binding)|go:"GO:0021545"(cranial nerve development)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038131"(neuregulin receptor activity)|go:"GO:0038132"(neuregulin binding)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051048"(negative regulation of secretion)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0055025"(positive regulation of cardiac muscle tissue development)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|reactome:R-MMU-1358803	ensembl:ENSMUSG00000062312(gene)|ensembl:ENSMUST00000058295(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010008"(endosome membrane)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043219"(lateral loop)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048678"(response to axon injury)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|reactome:R-MMU-1227986|reactome:R-MMU-1250196|reactome:R-MMU-1257604|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-416572|reactome:R-MMU-5673001|reactome:R-MMU-6785631|reactome:R-MMU-6811558|reactome:R-MMU-8847993|reactome:R-MMU-8863795|reactome:R-MMU-9652282|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|refseq:NP_001003817.1|dip:DIP-40912N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6b|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mammary gland)|taxid:10090(Mus musculus mammary gland)	-	2010/11/18	2014/10/16	rogid:HFP4VR1PpgpvSVSKWkV5iDI8FF010090	rogid:+lOIwIPXJnyC0pwki4J6+7mk1+w10090	intact-crc:C878518FB867FBCD|rigid:valzWUuwkCoNmU1gdv5TAhB8CfQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)