#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P03243-1	uniprotkb:F1M589	intact:EBI-1927377	intact:EBI-2941391|ensembl:ENSRNOP00000042091	psi-mi:p03243-1(display_long)|uniprotkb:E1B protein, large T-antigen(gene name synonym)|uniprotkb:E1B-495R(gene name synonym)|uniprotkb:E1B-55K(isoform synonym)	psi-mi:f1m589_rat(display_long)|uniprotkb:Pml(gene name)|psi-mi:Pml(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Wimmer et al. (2010)	pubmed:20639899|imex:IM-15171	taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1262"(I2D)	intact:EBI-6915358|imex:IM-15171-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1561361(isoform-parent)	ensembl:ENSRNOG00000008400(gene)|ensembl:ENSRNOT00000043434(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007569"(cell aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009411"(response to UV)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010522"(regulation of calcium ion transport into cytosol)|go:"GO:0010761"(fibroblast migration)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016605"(PML body)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030578"(PML body organization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034097"(response to cytokine)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090398"(cellular senescence)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0140037"(sumo-dependent protein binding)|go:"GO:1902187"|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000779"(regulation of double-strand break repair)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR021978|reactome:R-RNO-3108214|reactome:R-RNO-3232142|reactome:R-RNO-6804758|reactome:R-RNO-8934593|reactome:R-RNO-8948747|interpro:IPR017907|rgd:1562602	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig. 1a,b|agonist:Leptomycin B|comment:E1B-55K-wt accumulates in several bright stained nuclear aggregates clearly colocalizing with endogenous PML.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10114(rat-ab120)|taxid:10114(Rat AB120)	-	2010/10/18	2015/07/27	rogid:lSLIL2jDqtrteFfHliHdDPGlFHw28285	rogid:Fa7SMSqxTesNRQOBWFACBxiTYq410116	intact-crc:F3A50723983F3BAB|rigid:SqSkNoKxJKfR9dSQAq0PyKYj+3g	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P03243-1	uniprotkb:F1M589	intact:EBI-1927377	intact:EBI-2941391|ensembl:ENSRNOP00000042091	psi-mi:p03243-1(display_long)|uniprotkb:E1B protein, large T-antigen(gene name synonym)|uniprotkb:E1B-495R(gene name synonym)|uniprotkb:E1B-55K(isoform synonym)	psi-mi:f1m589_rat(display_long)|uniprotkb:Pml(gene name)|psi-mi:Pml(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Wimmer et al. (2010)	pubmed:20639899|imex:IM-15171	taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1262"(I2D)	intact:EBI-2936239|imex:IM-15171-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1561361(isoform-parent)	ensembl:ENSRNOG00000008400(gene)|ensembl:ENSRNOT00000043434(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007569"(cell aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009411"(response to UV)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010522"(regulation of calcium ion transport into cytosol)|go:"GO:0010761"(fibroblast migration)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016605"(PML body)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030578"(PML body organization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034097"(response to cytokine)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090398"(cellular senescence)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0140037"(sumo-dependent protein binding)|go:"GO:1902187"|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000779"(regulation of double-strand break repair)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR021978|reactome:R-RNO-3108214|reactome:R-RNO-3232142|reactome:R-RNO-6804758|reactome:R-RNO-8934593|reactome:R-RNO-8948747|interpro:IPR017907|rgd:1562602	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig. 1a,b|agonist:Leptomycin B|comment:E1B-55K-wt accumulates in several bright stained nuclear aggregates clearly colocalizing with endogenous PML.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10114(rat-ab115)|taxid:10114(Rattus AB115)	-	2010/10/18	2015/07/27	rogid:lSLIL2jDqtrteFfHliHdDPGlFHw28285	rogid:Fa7SMSqxTesNRQOBWFACBxiTYq410116	intact-crc:6FF24D3525908D89|rigid:SqSkNoKxJKfR9dSQAq0PyKYj+3g	false	mutation:83-83,91-91,87-87	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P03243-1	uniprotkb:F1M589	intact:EBI-1927377	intact:EBI-2941391|ensembl:ENSRNOP00000042091	psi-mi:p03243-1(display_long)|uniprotkb:E1B protein, large T-antigen(gene name synonym)|uniprotkb:E1B-495R(gene name synonym)|uniprotkb:E1B-55K(isoform synonym)	psi-mi:f1m589_rat(display_long)|uniprotkb:Pml(gene name)|psi-mi:Pml(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wimmer et al. (2010)	pubmed:20639899|imex:IM-15171	taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-6915435|imex:IM-15171-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1561361(isoform-parent)	ensembl:ENSRNOG00000008400(gene)|ensembl:ENSRNOT00000043434(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007569"(cell aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009411"(response to UV)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010522"(regulation of calcium ion transport into cytosol)|go:"GO:0010761"(fibroblast migration)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016605"(PML body)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030578"(PML body organization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034097"(response to cytokine)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090398"(cellular senescence)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0140037"(sumo-dependent protein binding)|go:"GO:1902187"|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000779"(regulation of double-strand break repair)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR021978|reactome:R-RNO-3108214|reactome:R-RNO-3232142|reactome:R-RNO-6804758|reactome:R-RNO-8934593|reactome:R-RNO-8948747|interpro:IPR017907|rgd:1562602	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10114(rat-ab120)|taxid:10114(Rat AB120)	-	2010/10/18	2015/07/27	rogid:lSLIL2jDqtrteFfHliHdDPGlFHw28285	rogid:Fa7SMSqxTesNRQOBWFACBxiTYq410116	intact-crc:6246A7CE9AED0159|rigid:SqSkNoKxJKfR9dSQAq0PyKYj+3g	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P03243-1	uniprotkb:F1M589	intact:EBI-1927377	intact:EBI-2941391|ensembl:ENSRNOP00000042091	psi-mi:p03243-1(display_long)|uniprotkb:E1B protein, large T-antigen(gene name synonym)|uniprotkb:E1B-495R(gene name synonym)|uniprotkb:E1B-55K(isoform synonym)	psi-mi:f1m589_rat(display_long)|uniprotkb:Pml(gene name)|psi-mi:Pml(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wimmer et al. (2010)	pubmed:20639899|imex:IM-15171	taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-6915432|imex:IM-15171-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1561361(isoform-parent)	ensembl:ENSRNOG00000008400(gene)|ensembl:ENSRNOT00000043434(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007569"(cell aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009411"(response to UV)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010522"(regulation of calcium ion transport into cytosol)|go:"GO:0010761"(fibroblast migration)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016605"(PML body)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030578"(PML body organization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034097"(response to cytokine)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090398"(cellular senescence)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0140037"(sumo-dependent protein binding)|go:"GO:1902187"|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000779"(regulation of double-strand break repair)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR021978|reactome:R-RNO-3108214|reactome:R-RNO-3232142|reactome:R-RNO-6804758|reactome:R-RNO-8934593|reactome:R-RNO-8948747|interpro:IPR017907|rgd:1562602	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1d|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10114(rat-ab120)|taxid:10114(Rat AB120)	-	2010/10/18	2015/07/27	rogid:lSLIL2jDqtrteFfHliHdDPGlFHw28285	rogid:Fa7SMSqxTesNRQOBWFACBxiTYq410116	intact-crc:C6D9EE465FA23645|rigid:SqSkNoKxJKfR9dSQAq0PyKYj+3g	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P03243-1	uniprotkb:F1M589	intact:EBI-1927377	intact:EBI-2941391|ensembl:ENSRNOP00000042091	psi-mi:p03243-1(display_long)|uniprotkb:E1B protein, large T-antigen(gene name synonym)|uniprotkb:E1B-495R(gene name synonym)|uniprotkb:E1B-55K(isoform synonym)	psi-mi:f1m589_rat(display_long)|uniprotkb:Pml(gene name)|psi-mi:Pml(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wimmer et al. (2010)	pubmed:20639899|imex:IM-15171	taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-2941414|imex:IM-15171-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1561361(isoform-parent)	ensembl:ENSRNOG00000008400(gene)|ensembl:ENSRNOT00000043434(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007569"(cell aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009411"(response to UV)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010522"(regulation of calcium ion transport into cytosol)|go:"GO:0010761"(fibroblast migration)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016605"(PML body)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030578"(PML body organization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034097"(response to cytokine)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090398"(cellular senescence)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0140037"(sumo-dependent protein binding)|go:"GO:1902187"|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000779"(regulation of double-strand break repair)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR021978|reactome:R-RNO-3108214|reactome:R-RNO-3232142|reactome:R-RNO-6804758|reactome:R-RNO-8934593|reactome:R-RNO-8948747|interpro:IPR017907|rgd:1562602	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10114(rat-ab115)|taxid:10114(Rattus AB115)	-	2010/10/18	2015/07/27	rogid:lSLIL2jDqtrteFfHliHdDPGlFHw28285	rogid:Fa7SMSqxTesNRQOBWFACBxiTYq410116	intact-crc:A1C29B260A0CBC70|rigid:SqSkNoKxJKfR9dSQAq0PyKYj+3g	false	mutation:83-83,87-87,91-91	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P03243-1	uniprotkb:F1M589	intact:EBI-1927377	intact:EBI-2941391|ensembl:ENSRNOP00000042091	psi-mi:p03243-1(display_long)|uniprotkb:E1B protein, large T-antigen(gene name synonym)|uniprotkb:E1B-495R(gene name synonym)|uniprotkb:E1B-55K(isoform synonym)	psi-mi:f1m589_rat(display_long)|uniprotkb:Pml(gene name)|psi-mi:Pml(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wimmer et al. (2010)	pubmed:20639899|imex:IM-15171	taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-2941418|imex:IM-15171-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1561361(isoform-parent)	ensembl:ENSRNOG00000008400(gene)|ensembl:ENSRNOT00000043434(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007569"(cell aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009411"(response to UV)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010522"(regulation of calcium ion transport into cytosol)|go:"GO:0010761"(fibroblast migration)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016605"(PML body)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030578"(PML body organization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034097"(response to cytokine)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090398"(cellular senescence)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0140037"(sumo-dependent protein binding)|go:"GO:1902187"|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000779"(regulation of double-strand break repair)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR021978|reactome:R-RNO-3108214|reactome:R-RNO-3232142|reactome:R-RNO-6804758|reactome:R-RNO-8934593|reactome:R-RNO-8948747|interpro:IPR017907|rgd:1562602	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1d|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10114(rat-ab115)|taxid:10114(Rattus AB115)	-	2010/10/18	2015/07/27	rogid:lSLIL2jDqtrteFfHliHdDPGlFHw28285	rogid:Fa7SMSqxTesNRQOBWFACBxiTYq410116	intact-crc:1859A6B518A68129|rigid:SqSkNoKxJKfR9dSQAq0PyKYj+3g	false	mutation:83-83,87-87,91-91	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P29590-5	uniprotkb:P03243-1	intact:EBI-304008|ensembl:ENSP00000378567	intact:EBI-1927377	psi-mi:p29590-5(display_long)|uniprotkb:PML(gene name)|psi-mi:PML(display_short)|uniprotkb:MYL(gene name synonym)|uniprotkb:RNF71(gene name synonym)|uniprotkb:TRIM19(gene name synonym)|uniprotkb:RING finger protein 71(gene name synonym)|uniprotkb:Tripartite motif-containing protein 19(gene name synonym)|uniprotkb:PML-IV(isoform synonym)|uniprotkb:PML-X(isoform synonym)|uniprotkb:TRIM19zeta(isoform synonym)|uniprotkb:Promyelocytic leukemia protein(gene name synonym)|uniprotkb:PP8675(gene name synonym)|uniprotkb:E3 SUMO-protein ligase PML(gene name synonym)|uniprotkb:RING-type E3 SUMO transferase PML(gene name synonym)	psi-mi:p03243-1(display_long)|uniprotkb:E1B protein, large T-antigen(gene name synonym)|uniprotkb:E1B-495R(gene name synonym)|uniprotkb:E1B-55K(isoform synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wimmer et al. (2010)	pubmed:20639899|imex:IM-15171	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-2941432|imex:IM-15171-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-295890(pml_human)|ensembl:ENSG00000140464(gene)|ensembl:ENST00000395135(transcript)	intact:EBI-1561361(isoform-parent)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2a, 3a, 5a|comment:Binding of E1B-55K is abolished upon superinfection of H1299 cells with 10f.f.u/cell of wild-type virus H5pg4100.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-h1299)|taxid:9606(Homo sapiens lung lymph node carcinoma)	-	2010/10/18	2014/10/16	rogid:sGzdYcuKdN6Kj34uS498dlF77PY9606	rogid:lSLIL2jDqtrteFfHliHdDPGlFHw28285	intact-crc:F31AD1725FCF95FC|rigid:VTeC2Jfmh9GzketDb8TI1JOorxs	false	flag tag:?-?	mutation disrupting interaction:103-103|mutation disrupting interaction:104-104	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P29590-2	uniprotkb:P03243-1	intact:EBI-303996|ensembl:ENSP00000395576	intact:EBI-1927377	psi-mi:p29590-2(display_long)|uniprotkb:PML(gene name)|psi-mi:PML(display_short)|uniprotkb:MYL(gene name synonym)|uniprotkb:RNF71(gene name synonym)|uniprotkb:TRIM19(gene name synonym)|uniprotkb:RING finger protein 71(gene name synonym)|uniprotkb:Tripartite motif-containing protein 19(gene name synonym)|uniprotkb:PML-2(isoform synonym)|uniprotkb:PML-V(isoform synonym)|uniprotkb:TRIM19beta(isoform synonym)|uniprotkb:Promyelocytic leukemia protein(gene name synonym)|uniprotkb:PP8675(gene name synonym)|uniprotkb:E3 SUMO-protein ligase PML(gene name synonym)|uniprotkb:RING-type E3 SUMO transferase PML(gene name synonym)	psi-mi:p03243-1(display_long)|uniprotkb:E1B protein, large T-antigen(gene name synonym)|uniprotkb:E1B-495R(gene name synonym)|uniprotkb:E1B-55K(isoform synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wimmer et al. (2010)	pubmed:20639899|imex:IM-15171	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-2942015|imex:IM-15171-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-295890(pml_human)|ensembl:ENSG00000140464(gene)|ensembl:ENST00000435786(transcript)|uniprotkb:P29590-2(isoform-parent)	intact:EBI-1561361(isoform-parent)	psi-mi:"MI:0469"(intact)	isoform-comment:"Ref.5 (AAG50181) sequence is in conflict in position: 578:P->A. Contains a phosphoserine at position 565."	-	figure legend:Fig. 2a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-h1299)|taxid:9606(Homo sapiens lung lymph node carcinoma)	-	2010/10/18	2014/10/16	rogid:+fRuye0ANEW1KaFIUBFhHCMymZ09606	rogid:lSLIL2jDqtrteFfHliHdDPGlFHw28285	intact-crc:79952488C5712E20|rigid:9Ed9QmnL/Az4qnvA2XQz1O60qn0	false	flag tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P29590-1	uniprotkb:P03243-1	intact:EBI-303992|ensembl:ENSP00000268058	intact:EBI-1927377	psi-mi:p29590-1(display_long)|uniprotkb:PML(gene name)|psi-mi:PML(display_short)|uniprotkb:MYL(gene name synonym)|uniprotkb:RNF71(gene name synonym)|uniprotkb:TRIM19(gene name synonym)|uniprotkb:RING finger protein 71(gene name synonym)|uniprotkb:Tripartite motif-containing protein 19(gene name synonym)|uniprotkb:PML-I(isoform synonym)|uniprotkb:TRIM19alpha(isoform synonym)|uniprotkb:Promyelocytic leukemia protein(gene name synonym)|uniprotkb:PP8675(gene name synonym)|uniprotkb:E3 SUMO-protein ligase PML(gene name synonym)|uniprotkb:RING-type E3 SUMO transferase PML(gene name synonym)	psi-mi:p03243-1(display_long)|uniprotkb:E1B protein, large T-antigen(gene name synonym)|uniprotkb:E1B-495R(gene name synonym)|uniprotkb:E1B-55K(isoform synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wimmer et al. (2010)	pubmed:20639899|imex:IM-15171	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-2942021|imex:IM-15171-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-295890(pml_human)|ensembl:ENSG00000140464(gene)|ensembl:ENST00000268058(transcript)	intact:EBI-1561361(isoform-parent)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3a|comment:Specific binding of E1B-55K is observed upon superinfection of H1299 cells with 10f.f.u/cell of wild-type virus H5pg4100.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-h1299)|taxid:9606(Homo sapiens lung lymph node carcinoma)	-	2010/10/18	2014/10/16	rogid:FdAh5Rbyu37luTScMzCopbbwXvk9606	rogid:lSLIL2jDqtrteFfHliHdDPGlFHw28285	intact-crc:D99C61CAF73D4788|rigid:D5eJX0evTPuu65doK10FqIJsMUM	false	flag tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P29590-4	uniprotkb:P03243-1	intact:EBI-304004|ensembl:ENSP00000394642|ensembl:ENSP00000456486	intact:EBI-1927377	psi-mi:p29590-4(display_long)|uniprotkb:PML(gene name)|psi-mi:PML(display_short)|uniprotkb:MYL(gene name synonym)|uniprotkb:RNF71(gene name synonym)|uniprotkb:TRIM19(gene name synonym)|uniprotkb:RING finger protein 71(gene name synonym)|uniprotkb:Tripartite motif-containing protein 19(gene name synonym)|uniprotkb:PML-3B(isoform synonym)|uniprotkb:PML-VI(isoform synonym)|uniprotkb:TRIM19epsilon(isoform synonym)|uniprotkb:Promyelocytic leukemia protein(gene name synonym)|uniprotkb:PP8675(gene name synonym)|uniprotkb:E3 SUMO-protein ligase PML(gene name synonym)|uniprotkb:RING-type E3 SUMO transferase PML(gene name synonym)	psi-mi:p03243-1(display_long)|uniprotkb:E1B protein, large T-antigen(gene name synonym)|uniprotkb:E1B-495R(gene name synonym)|uniprotkb:E1B-55K(isoform synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wimmer et al. (2010)	pubmed:20639899|imex:IM-15171	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-2942030|imex:IM-15171-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-295890(pml_human)|ensembl:ENSG00000140464(gene)|ensembl:ENST00000436891(transcript)|ensembl:ENST00000569965(transcript)	intact:EBI-1561361(isoform-parent)	psi-mi:"MI:0469"(intact)	isoform-comment:Contains a phosphoserine at position 518. Contains a phosphoserine at position 527. Contains a phosphoserine at position 530.	-	figure legend:Fig. 3a|comment:Specific binding of E1B-55K is observed upon superinfection of H1299 cells with 10f.f.u/cell of wild-type virus H5pg4100.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-h1299)|taxid:9606(Homo sapiens lung lymph node carcinoma)	-	2010/10/18	2014/10/16	rogid:7Qv+/MeEQm0nHBnZdudPQApmaQk9606	rogid:lSLIL2jDqtrteFfHliHdDPGlFHw28285	intact-crc:FBDD6234EB07D421|rigid:IIJcF1G+wBH+CEMxeAxno4x2Ivg	false	flag tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P29590-5	uniprotkb:P03243-1	intact:EBI-304008|ensembl:ENSP00000378567	intact:EBI-1927377	psi-mi:p29590-5(display_long)|uniprotkb:PML(gene name)|psi-mi:PML(display_short)|uniprotkb:MYL(gene name synonym)|uniprotkb:RNF71(gene name synonym)|uniprotkb:TRIM19(gene name synonym)|uniprotkb:RING finger protein 71(gene name synonym)|uniprotkb:Tripartite motif-containing protein 19(gene name synonym)|uniprotkb:PML-IV(isoform synonym)|uniprotkb:PML-X(isoform synonym)|uniprotkb:TRIM19zeta(isoform synonym)|uniprotkb:Promyelocytic leukemia protein(gene name synonym)|uniprotkb:PP8675(gene name synonym)|uniprotkb:E3 SUMO-protein ligase PML(gene name synonym)|uniprotkb:RING-type E3 SUMO transferase PML(gene name synonym)	psi-mi:p03243-1(display_long)|uniprotkb:E1B protein, large T-antigen(gene name synonym)|uniprotkb:E1B-495R(gene name synonym)|uniprotkb:E1B-55K(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wimmer et al. (2010)	pubmed:20639899|imex:IM-15171	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-2942052|imex:IM-15171-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-295890(pml_human)|ensembl:ENSG00000140464(gene)|ensembl:ENST00000395135(transcript)	intact:EBI-1561361(isoform-parent)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-h1299)|taxid:9606(Homo sapiens lung lymph node carcinoma)	-	2010/10/18	2014/10/16	rogid:sGzdYcuKdN6Kj34uS498dlF77PY9606	rogid:lSLIL2jDqtrteFfHliHdDPGlFHw28285	intact-crc:2A6B532CE51A0901|rigid:VTeC2Jfmh9GzketDb8TI1JOorxs	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P29590-2	uniprotkb:P03243-1	intact:EBI-303996|ensembl:ENSP00000395576	intact:EBI-1927377	psi-mi:p29590-2(display_long)|uniprotkb:PML(gene name)|psi-mi:PML(display_short)|uniprotkb:MYL(gene name synonym)|uniprotkb:RNF71(gene name synonym)|uniprotkb:TRIM19(gene name synonym)|uniprotkb:RING finger protein 71(gene name synonym)|uniprotkb:Tripartite motif-containing protein 19(gene name synonym)|uniprotkb:PML-2(isoform synonym)|uniprotkb:PML-V(isoform synonym)|uniprotkb:TRIM19beta(isoform synonym)|uniprotkb:Promyelocytic leukemia protein(gene name synonym)|uniprotkb:PP8675(gene name synonym)|uniprotkb:E3 SUMO-protein ligase PML(gene name synonym)|uniprotkb:RING-type E3 SUMO transferase PML(gene name synonym)	psi-mi:p03243-1(display_long)|uniprotkb:E1B protein, large T-antigen(gene name synonym)|uniprotkb:E1B-495R(gene name synonym)|uniprotkb:E1B-55K(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wimmer et al. (2010)	pubmed:20639899|imex:IM-15171	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-2942059|imex:IM-15171-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-295890(pml_human)|ensembl:ENSG00000140464(gene)|ensembl:ENST00000435786(transcript)|uniprotkb:P29590-2(isoform-parent)	intact:EBI-1561361(isoform-parent)	psi-mi:"MI:0469"(intact)	isoform-comment:"Ref.5 (AAG50181) sequence is in conflict in position: 578:P->A. Contains a phosphoserine at position 565."	-	figure legend:Fig. 2b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-h1299)|taxid:9606(Homo sapiens lung lymph node carcinoma)	-	2010/10/18	2014/10/16	rogid:+fRuye0ANEW1KaFIUBFhHCMymZ09606	rogid:lSLIL2jDqtrteFfHliHdDPGlFHw28285	intact-crc:6D61268EBA3AFE0B|rigid:9Ed9QmnL/Az4qnvA2XQz1O60qn0	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P03243-1	uniprotkb:P29590	intact:EBI-1927377	intact:EBI-295890|ensembl:ENSP00000268058|uniprotkb:P29591|uniprotkb:P29592|uniprotkb:P29593|uniprotkb:Q00755|uniprotkb:Q96S41|intact:EBI-779712|intact:EBI-1210702|intact:EBI-870812|uniprotkb:Q15959|uniprotkb:Q59FP9|uniprotkb:Q8WUA0|uniprotkb:Q9BPW2|uniprotkb:Q9BWP7|uniprotkb:Q9BZX6|uniprotkb:Q9BZX7|uniprotkb:Q9BZX8|uniprotkb:Q9BZX9|uniprotkb:Q9BZY0|uniprotkb:Q9BZY2|uniprotkb:Q9BZY3|uniprotkb:E9PBR7	psi-mi:p03243-1(display_long)|uniprotkb:E1B protein, large T-antigen(gene name synonym)|uniprotkb:E1B-495R(gene name synonym)|uniprotkb:E1B-55K(isoform synonym)	psi-mi:pml_human(display_long)|uniprotkb:PML(gene name)|psi-mi:PML(display_short)|uniprotkb:MYL(gene name synonym)|uniprotkb:RNF71(gene name synonym)|uniprotkb:TRIM19(gene name synonym)|uniprotkb:Tripartite motif-containing protein 19(gene name synonym)|uniprotkb:RING finger protein 71(gene name synonym)|uniprotkb:Promyelocytic leukemia protein(gene name synonym)|uniprotkb:PP8675(gene name synonym)|uniprotkb:E3 SUMO-protein ligase PML(gene name synonym)|uniprotkb:RING-type E3 SUMO transferase PML(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Wimmer et al. (2010)	pubmed:20639899|imex:IM-15171	taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1262"(I2D)	intact:EBI-2942074|imex:IM-15171-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1561361(isoform-parent)	ensembl:ENST00000268058(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|ensembl:ENSG00000140464(gene)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006605"(protein targeting)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009411"(response to UV)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010522"(regulation of calcium ion transport into cytosol)|go:"GO:0005829"(cytosol)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016605"(PML body)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030578"(PML body organization)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032183"(SUMO binding)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0010761"(fibroblast migration)|go:"GO:0034097"(response to cytokine)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0032938"(negative regulation of translation in response to oxidative stress)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046332"(SMAD binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0050821"(protein stabilization)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060058"(positive regulation of apoptotic process involved in mammary gland involution)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0090398"(cellular senescence)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0140037"(sumo-dependent protein binding)|go:"GO:1902187"|go:"GO:1904816"(positive regulation of protein localization to chromosome, telomeric region)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|rcsb pdb:2MWX|rcsb pdb:4WJN|rcsb pdb:4WJO|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|rcsb pdb:5YUF|go:"GO:2000779"(regulation of double-strand break repair)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000315(Zinc finger, B-box)|rcsb pdb:6IMQ|rcsb pdb:6UYO|rcsb pdb:6UYP|interpro:IPR001841(Zinc finger, RING-type)|rcsb pdb:6UYQ|rcsb pdb:6UYR|rcsb pdb:6UYS|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|rcsb pdb:6UYT|rcsb pdb:6UYU|rcsb pdb:6UYV|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-6804758|reactome:R-HSA-877300|reactome:R-HSA-8934593|reactome:R-HSA-8948747|reactome:R-HSA-9609690|reactome:R-HSA-9616222|interpro:IPR021978|mint:P29590|rcsb pdb:1BOR|rcsb pdb:2MVW|refseq:NP_002666.1|refseq:NP_150241.2|refseq:NP_150242.1|refseq:NP_150243.2|refseq:NP_150247.2|refseq:NP_150249.1|refseq:NP_150250.2|refseq:NP_150252.1|refseq:NP_150253.2|dip:DIP-33053N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig. 4a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-heparg)|taxid:9606(Homo sapiens hepatoma)	-	2010/10/18	2014/10/16	rogid:lSLIL2jDqtrteFfHliHdDPGlFHw28285	rogid:FdAh5Rbyu37luTScMzCopbbwXvk9606	intact-crc:F807AC2CEAE97377|rigid:D5eJX0evTPuu65doK10FqIJsMUM	false	mutation disrupting interaction:104-104	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P03243-1	uniprotkb:P29590	intact:EBI-1927377	intact:EBI-295890|ensembl:ENSP00000268058|uniprotkb:P29591|uniprotkb:P29592|uniprotkb:P29593|uniprotkb:Q00755|uniprotkb:Q96S41|intact:EBI-779712|intact:EBI-1210702|intact:EBI-870812|uniprotkb:Q15959|uniprotkb:Q59FP9|uniprotkb:Q8WUA0|uniprotkb:Q9BPW2|uniprotkb:Q9BWP7|uniprotkb:Q9BZX6|uniprotkb:Q9BZX7|uniprotkb:Q9BZX8|uniprotkb:Q9BZX9|uniprotkb:Q9BZY0|uniprotkb:Q9BZY2|uniprotkb:Q9BZY3|uniprotkb:E9PBR7	psi-mi:p03243-1(display_long)|uniprotkb:E1B protein, large T-antigen(gene name synonym)|uniprotkb:E1B-495R(gene name synonym)|uniprotkb:E1B-55K(isoform synonym)	psi-mi:pml_human(display_long)|uniprotkb:PML(gene name)|psi-mi:PML(display_short)|uniprotkb:MYL(gene name synonym)|uniprotkb:RNF71(gene name synonym)|uniprotkb:TRIM19(gene name synonym)|uniprotkb:Tripartite motif-containing protein 19(gene name synonym)|uniprotkb:RING finger protein 71(gene name synonym)|uniprotkb:Promyelocytic leukemia protein(gene name synonym)|uniprotkb:PP8675(gene name synonym)|uniprotkb:E3 SUMO-protein ligase PML(gene name synonym)|uniprotkb:RING-type E3 SUMO transferase PML(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wimmer et al. (2010)	pubmed:20639899|imex:IM-15171	taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-2942089|imex:IM-15171-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1561361(isoform-parent)	ensembl:ENST00000268058(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|ensembl:ENSG00000140464(gene)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006605"(protein targeting)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009411"(response to UV)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010522"(regulation of calcium ion transport into cytosol)|go:"GO:0005829"(cytosol)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016605"(PML body)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030578"(PML body organization)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032183"(SUMO binding)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0010761"(fibroblast migration)|go:"GO:0034097"(response to cytokine)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0032938"(negative regulation of translation in response to oxidative stress)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046332"(SMAD binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0050821"(protein stabilization)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060058"(positive regulation of apoptotic process involved in mammary gland involution)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0090398"(cellular senescence)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0140037"(sumo-dependent protein binding)|go:"GO:1902187"|go:"GO:1904816"(positive regulation of protein localization to chromosome, telomeric region)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|rcsb pdb:2MWX|rcsb pdb:4WJN|rcsb pdb:4WJO|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|rcsb pdb:5YUF|go:"GO:2000779"(regulation of double-strand break repair)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000315(Zinc finger, B-box)|rcsb pdb:6IMQ|rcsb pdb:6UYO|rcsb pdb:6UYP|interpro:IPR001841(Zinc finger, RING-type)|rcsb pdb:6UYQ|rcsb pdb:6UYR|rcsb pdb:6UYS|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|rcsb pdb:6UYT|rcsb pdb:6UYU|rcsb pdb:6UYV|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-6804758|reactome:R-HSA-877300|reactome:R-HSA-8934593|reactome:R-HSA-8948747|reactome:R-HSA-9609690|reactome:R-HSA-9616222|interpro:IPR021978|mint:P29590|rcsb pdb:1BOR|rcsb pdb:2MVW|refseq:NP_002666.1|refseq:NP_150241.2|refseq:NP_150242.1|refseq:NP_150243.2|refseq:NP_150247.2|refseq:NP_150249.1|refseq:NP_150250.2|refseq:NP_150252.1|refseq:NP_150253.2|dip:DIP-33053N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-heparg)|taxid:9606(Homo sapiens hepatoma)	-	2010/10/18	2014/10/16	rogid:lSLIL2jDqtrteFfHliHdDPGlFHw28285	rogid:FdAh5Rbyu37luTScMzCopbbwXvk9606	intact-crc:BE96A7EBB8BFFD07|rigid:D5eJX0evTPuu65doK10FqIJsMUM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)