#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99LM3	uniprotkb:P58772	intact:EBI-8073484|intact:MINT-7966054|ensembl:ENSMUSP00000028471	intact:EBI-7906242|uniprotkb:P02558|uniprotkb:P46902|intact:MINT-1500045|uniprotkb:P99034	psi-mi:smtl1_mouse(display_long)|uniprotkb:Calponin homology-associated smooth muscle protein(gene name synonym)|uniprotkb:Smtnl1(gene name)|psi-mi:Smtnl1(display_short)	psi-mi:tpm1_rabit(display_long)|uniprotkb:TPM1(gene name)|psi-mi:TPM1(display_short)|uniprotkb:TPMA(gene name synonym)|uniprotkb:Tropomyosin-1(gene name synonym)|uniprotkb:Alpha-tropomyosin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ulke-Lemée et al. (2010)	pubmed:20627103|imex:IM-15597|mint:MINT-7966037|doi:10.1016/j.febslet.2010.07.012	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8073478|mint:MINT-7966073|imex:IM-15597-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077192.1|refseq:XP_006500172.1|ensembl:ENSMUSG00000027077(gene)|ensembl:ENSMUST00000028471(transcript)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0014823"(response to activity)|go:"GO:0017020"(myosin phosphatase regulator activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0031941"(filamentous actin)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042493"|go:"GO:0043292"(contractile fiber)|go:"GO:0043621"(protein self-association)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0051401"(CH domain binding)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR036872|rcsb pdb:2JV9|rcsb pdb:2K3S|mint:MINT-7966077(identity)	refseq:NP_001099158.1|dip:DIP-46098N|rcsb pdb:4A7F|rcsb pdb:4A7H|rcsb pdb:4A7L|go:"GO:0005737"(cytoplasm)|go:"GO:0005884"(actin filament)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0031013"(troponin I binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051015"(actin filament binding)|interpro:IPR000533(Tropomyosin)|rcsb pdb:2D3E|rcsb pdb:2EFR|rcsb pdb:2EFS|rcsb pdb:2TMA|rcsb pdb:2W49|rcsb pdb:2W4U|rcsb pdb:2Z5H|rcsb pdb:2Z5I|mint:MINT-7966076(identity)	-	comment:mint	function:Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments|comment:mint	figure legend:f2|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/07/07	2014/10/16	rogid:4CsKqotycSLo1/ZPQA7BJtM19+E10090	rogid:d/imATvus0XZvr7i//2MtbXZ7Pw9986	intact-crc:1E8E390D2463AA14|rigid:/EJRnKercp4TfsbBx9I2Rp/v/gM	false	binding-associated region:346-459(MINT-7966086)|glutathione s tranferase tag:?-?(MINT-7966083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q99LM3	uniprotkb:P58776	intact:EBI-8073484|intact:MINT-7966054|ensembl:ENSMUSP00000028471	intact:EBI-8073508|intact:MINT-7966042|uniprotkb:P02560	psi-mi:smtl1_mouse(display_long)|uniprotkb:Calponin homology-associated smooth muscle protein(gene name synonym)|uniprotkb:Smtnl1(gene name)|psi-mi:Smtnl1(display_short)	psi-mi:tpm2_rabit(display_long)|uniprotkb:TPM2(gene name)|psi-mi:TPM2(display_short)|uniprotkb:Tropomyosin-2(gene name synonym)|uniprotkb:Beta-tropomyosin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ulke-Lemée et al. (2010)	pubmed:20627103|imex:IM-15597|mint:MINT-7966037|doi:10.1016/j.febslet.2010.07.012	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8073478|mint:MINT-7966073|imex:IM-15597-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077192.1|refseq:XP_006500172.1|ensembl:ENSMUSG00000027077(gene)|ensembl:ENSMUST00000028471(transcript)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0014823"(response to activity)|go:"GO:0017020"(myosin phosphatase regulator activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0031941"(filamentous actin)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042493"|go:"GO:0043292"(contractile fiber)|go:"GO:0043621"(protein self-association)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0051401"(CH domain binding)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR036872|rcsb pdb:2JV9|rcsb pdb:2K3S|mint:MINT-7966077(identity)	refseq:XP_017194790.1|interpro:IPR000533(Tropomyosin)|go:"GO:0005737"(cytoplasm)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051015"(actin filament binding)|mint:MINT-7966075(identity)	-	comment:mint	comment:mint	figure legend:f2|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/07/07	2014/10/16	rogid:4CsKqotycSLo1/ZPQA7BJtM19+E10090	rogid:1tQz/rVgRBdZs8ZldhnRA5OqaPc9986	intact-crc:1E8E390D2463AA14|rigid:/EJRnKercp4TfsbBx9I2Rp/v/gM	false	binding-associated region:346-459(MINT-7966086)|glutathione s tranferase tag:?-?(MINT-7966083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q99LM3	uniprotkb:P04268	intact:EBI-8073484|intact:MINT-7966054|ensembl:ENSMUSP00000028471	intact:EBI-8073544|uniprotkb:P02559|uniprotkb:P49436|uniprotkb:P08942|uniprotkb:P18441|uniprotkb:P49438|uniprotkb:Q540N4|uniprotkb:P18442|intact:UNK-6021497|uniprotkb:P49439	psi-mi:smtl1_mouse(display_long)|uniprotkb:Calponin homology-associated smooth muscle protein(gene name synonym)|uniprotkb:Smtnl1(gene name)|psi-mi:Smtnl1(display_short)	psi-mi:tpm1_chick(display_long)|uniprotkb:TPM1(gene name)|psi-mi:TPM1(display_short)|uniprotkb:Tropomyosin-1(gene name synonym)|uniprotkb:Alpha-tropomyosin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ulke-Lemée et al. (2010)	pubmed:20627103|imex:IM-15597|mint:MINT-7966037|doi:10.1016/j.febslet.2010.07.012	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8073537|mint:MINT-7966090|imex:IM-15597-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077192.1|refseq:XP_006500172.1|ensembl:ENSMUSG00000027077(gene)|ensembl:ENSMUST00000028471(transcript)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0014823"(response to activity)|go:"GO:0017020"(myosin phosphatase regulator activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0031941"(filamentous actin)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042493"|go:"GO:0043292"(contractile fiber)|go:"GO:0043621"(protein self-association)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0051401"(CH domain binding)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR036872|rcsb pdb:2JV9|rcsb pdb:2K3S|mint:MINT-7966096(identity)	refseq:XP_015134260.1|refseq:XP_015134264.1|refseq:XP_015134271.1|interpro:IPR000533(Tropomyosin)|rcsb pdb:3U1A|refseq:NP_990732.1|rcsb pdb:3MUD|rcsb pdb:1IC2|rcsb pdb:3MTU|rcsb pdb:3U1C|reactome:R-GGA-445355|go:"GO:0005737"(cytoplasm)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006936"(muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0060048"(cardiac muscle contraction)|mint:MINT-7966094(identity)	-	comment:mint	function:Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments|comment:mint	figure legend:f3a|comment:homomint|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/07/07	2014/10/16	rogid:4CsKqotycSLo1/ZPQA7BJtM19+E10090	rogid:9L+Pdvpc4y/snwZQKGjKr9is2D09031	intact-crc:0ED8B60100D1C578|rigid:ICLZOU3z0Kpq+xykJU/3V2LNjQY	false	binding-associated region:195-459(MINT-7966097)	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99LM3	uniprotkb:P04268	intact:EBI-8073484|intact:MINT-7966054|ensembl:ENSMUSP00000028471	intact:EBI-8073544|uniprotkb:P02559|uniprotkb:P49436|uniprotkb:P08942|uniprotkb:P18441|uniprotkb:P49438|uniprotkb:Q540N4|uniprotkb:P18442|intact:UNK-6021497|uniprotkb:P49439	psi-mi:smtl1_mouse(display_long)|uniprotkb:Calponin homology-associated smooth muscle protein(gene name synonym)|uniprotkb:Smtnl1(gene name)|psi-mi:Smtnl1(display_short)	psi-mi:tpm1_chick(display_long)|uniprotkb:TPM1(gene name)|psi-mi:TPM1(display_short)|uniprotkb:Tropomyosin-1(gene name synonym)|uniprotkb:Alpha-tropomyosin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ulke-Lemée et al. (2010)	pubmed:20627103|imex:IM-15597|mint:MINT-7966037|doi:10.1016/j.febslet.2010.07.012	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8073604|mint:MINT-7966187|imex:IM-15597-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077192.1|refseq:XP_006500172.1|ensembl:ENSMUSG00000027077(gene)|ensembl:ENSMUST00000028471(transcript)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0014823"(response to activity)|go:"GO:0017020"(myosin phosphatase regulator activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0031941"(filamentous actin)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042493"|go:"GO:0043292"(contractile fiber)|go:"GO:0043621"(protein self-association)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0051401"(CH domain binding)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR036872|rcsb pdb:2JV9|rcsb pdb:2K3S|mint:MINT-7966190(identity)	refseq:XP_015134260.1|refseq:XP_015134264.1|refseq:XP_015134271.1|interpro:IPR000533(Tropomyosin)|rcsb pdb:3U1A|refseq:NP_990732.1|rcsb pdb:3MUD|rcsb pdb:1IC2|rcsb pdb:3MTU|rcsb pdb:3U1C|reactome:R-GGA-445355|go:"GO:0005737"(cytoplasm)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006936"(muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0060048"(cardiac muscle contraction)|mint:MINT-7966195(identity)	-	comment:mint	function:Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments|comment:mint	figure legend:f3d|comment:homomint|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/07/07	2014/10/16	rogid:4CsKqotycSLo1/ZPQA7BJtM19+E10090	rogid:9L+Pdvpc4y/snwZQKGjKr9is2D09031	intact-crc:B78D3A5D7840AF72|rigid:+G10L3+y50ewVvTv4lkRMxu0I1c	false	binding-associated region:346-459(MINT-7966191)	tag:?-?(MINT-7966207)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99LM3	uniprotkb:P19352	intact:EBI-8073484|intact:MINT-7966054|ensembl:ENSMUSP00000028471	intact:EBI-8073611|uniprotkb:P04267|uniprotkb:P19353|intact:MINT-7966140	psi-mi:smtl1_mouse(display_long)|uniprotkb:Calponin homology-associated smooth muscle protein(gene name synonym)|uniprotkb:Smtnl1(gene name)|psi-mi:Smtnl1(display_short)	psi-mi:tpm2_chick(display_long)|uniprotkb:TPM2(gene name)|psi-mi:TPM2(display_short)|uniprotkb:Tropomyosin-2(gene name synonym)|uniprotkb:Beta-tropomyosin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ulke-Lemée et al. (2010)	pubmed:20627103|imex:IM-15597|mint:MINT-7966037|doi:10.1016/j.febslet.2010.07.012	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8073604|mint:MINT-7966187|imex:IM-15597-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077192.1|refseq:XP_006500172.1|ensembl:ENSMUSG00000027077(gene)|ensembl:ENSMUST00000028471(transcript)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0014823"(response to activity)|go:"GO:0017020"(myosin phosphatase regulator activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0031941"(filamentous actin)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042493"|go:"GO:0043292"(contractile fiber)|go:"GO:0043621"(protein self-association)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0051401"(CH domain binding)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR036872|rcsb pdb:2JV9|rcsb pdb:2K3S|mint:MINT-7966190(identity)	refseq:XP_015132746.1|refseq:XP_015132749.1|refseq:XP_015132753.1|rcsb pdb:3U59|interpro:IPR000533(Tropomyosin)|go:"GO:0006936"(muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005884"(actin filament)|mint:MINT-7966197(identity)	-	comment:mint	comment:mint	figure legend:f3d|comment:homomint|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/07/07	2014/10/16	rogid:4CsKqotycSLo1/ZPQA7BJtM19+E10090	rogid:YbOsXCcm8Ao1TcKsn5BAxSOmU6g9031	intact-crc:B78D3A5D7840AF72|rigid:+G10L3+y50ewVvTv4lkRMxu0I1c	false	binding-associated region:346-459(MINT-7966191)	tag:?-?(MINT-7966210)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99LM3	uniprotkb:P04268	intact:EBI-8073484|intact:MINT-7966054|ensembl:ENSMUSP00000028471	intact:EBI-8073544|uniprotkb:P02559|uniprotkb:P49436|uniprotkb:P08942|uniprotkb:P18441|uniprotkb:P49438|uniprotkb:Q540N4|uniprotkb:P18442|intact:UNK-6021497|uniprotkb:P49439	psi-mi:smtl1_mouse(display_long)|uniprotkb:Calponin homology-associated smooth muscle protein(gene name synonym)|uniprotkb:Smtnl1(gene name)|psi-mi:Smtnl1(display_short)	psi-mi:tpm1_chick(display_long)|uniprotkb:TPM1(gene name)|psi-mi:TPM1(display_short)|uniprotkb:Tropomyosin-1(gene name synonym)|uniprotkb:Alpha-tropomyosin(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Ulke-Lemée et al. (2010)	pubmed:20627103|imex:IM-15597|mint:MINT-7966037|doi:10.1016/j.febslet.2010.07.012	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8073656|mint:MINT-7966126|imex:IM-15597-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077192.1|refseq:XP_006500172.1|ensembl:ENSMUSG00000027077(gene)|ensembl:ENSMUST00000028471(transcript)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0014823"(response to activity)|go:"GO:0017020"(myosin phosphatase regulator activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0031941"(filamentous actin)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042493"|go:"GO:0043292"(contractile fiber)|go:"GO:0043621"(protein self-association)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0051401"(CH domain binding)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR036872|rcsb pdb:2JV9|rcsb pdb:2K3S|mint:MINT-7966128(identity)	refseq:XP_015134260.1|refseq:XP_015134264.1|refseq:XP_015134271.1|interpro:IPR000533(Tropomyosin)|rcsb pdb:3U1A|refseq:NP_990732.1|rcsb pdb:3MUD|rcsb pdb:1IC2|rcsb pdb:3MTU|rcsb pdb:3U1C|reactome:R-GGA-445355|go:"GO:0005737"(cytoplasm)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006936"(muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0060048"(cardiac muscle contraction)|mint:MINT-7966135(identity)	-	comment:mint	function:Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments|comment:mint	figure legend:f4|comment:homomint|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.0x10^-6(molar)	2010/07/07	2014/10/16	rogid:4CsKqotycSLo1/ZPQA7BJtM19+E10090	rogid:9L+Pdvpc4y/snwZQKGjKr9is2D09031	intact-crc:0525EBE0B7A1A3C1|rigid:+G10L3+y50ewVvTv4lkRMxu0I1c	false	binding-associated region:346-459(MINT-7966129)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99LM3	uniprotkb:P19352	intact:EBI-8073484|intact:MINT-7966054|ensembl:ENSMUSP00000028471	intact:EBI-8073611|uniprotkb:P04267|uniprotkb:P19353|intact:MINT-7966140	psi-mi:smtl1_mouse(display_long)|uniprotkb:Calponin homology-associated smooth muscle protein(gene name synonym)|uniprotkb:Smtnl1(gene name)|psi-mi:Smtnl1(display_short)	psi-mi:tpm2_chick(display_long)|uniprotkb:TPM2(gene name)|psi-mi:TPM2(display_short)|uniprotkb:Tropomyosin-2(gene name synonym)|uniprotkb:Beta-tropomyosin(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Ulke-Lemée et al. (2010)	pubmed:20627103|imex:IM-15597|mint:MINT-7966037|doi:10.1016/j.febslet.2010.07.012	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8073656|mint:MINT-7966126|imex:IM-15597-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077192.1|refseq:XP_006500172.1|ensembl:ENSMUSG00000027077(gene)|ensembl:ENSMUST00000028471(transcript)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0014823"(response to activity)|go:"GO:0017020"(myosin phosphatase regulator activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0031941"(filamentous actin)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042493"|go:"GO:0043292"(contractile fiber)|go:"GO:0043621"(protein self-association)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0051401"(CH domain binding)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR036872|rcsb pdb:2JV9|rcsb pdb:2K3S|mint:MINT-7966128(identity)	refseq:XP_015132746.1|refseq:XP_015132749.1|refseq:XP_015132753.1|rcsb pdb:3U59|interpro:IPR000533(Tropomyosin)|go:"GO:0006936"(muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005884"(actin filament)|mint:MINT-7966180(identity)	-	comment:mint	comment:mint	figure legend:f4|comment:homomint|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.0x10^-6(molar)	2010/07/07	2014/10/16	rogid:4CsKqotycSLo1/ZPQA7BJtM19+E10090	rogid:YbOsXCcm8Ao1TcKsn5BAxSOmU6g9031	intact-crc:0525EBE0B7A1A3C1|rigid:+G10L3+y50ewVvTv4lkRMxu0I1c	false	binding-associated region:346-459(MINT-7966129)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)