#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P27732	uniprotkb:O88871	intact:EBI-8072674|uniprotkb:Q63491|uniprotkb:Q63492|uniprotkb:Q62691|uniprotkb:Q01542|uniprotkb:O09024|intact:MINT-7965882|uniprotkb:O09022|uniprotkb:Q62815|uniprotkb:O09023	intact:EBI-7090239|intact:MINT-1889821|uniprotkb:Q9QWU2|uniprotkb:Q9JK36	psi-mi:cac1d_rat(display_long)|uniprotkb:Cacna1d(gene name)|psi-mi:Cacna1d(display_short)|uniprotkb:Cach3(gene name synonym)|uniprotkb:Cacn4(gene name synonym)|uniprotkb:Cacnl1a2(gene name synonym)|uniprotkb:Cchl1a2(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.3(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 2(gene name synonym)|uniprotkb:Rat brain class D(gene name synonym)	psi-mi:gabr2_rat(display_long)|uniprotkb:Gabbr2(gene name)|psi-mi:Gabbr2(display_short)|uniprotkb:Gpr51(gene name synonym)|uniprotkb:G-protein coupled receptor 51(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Park et al. (2010)	pubmed:20627102|imex:IM-15596|mint:MINT-7965874|doi:10.1016/j.febslet.2010.07.014	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8072668|mint:MINT-7966007|imex:IM-15596-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:70973|refseq:NP_058994.1|dip:DIP-60740N|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904879"(positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005452(Voltage-dependent calcium channel, L-type, alpha-1D subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007613"(memory)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030506"(ankyrin binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060372"(regulation of atrial cardiac muscle cell membrane repolarization)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086007"(voltage-gated calcium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086059"(voltage-gated calcium channel activity involved SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098683"(cochlear hair cell ribbon synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|reactome:R-RNO-422356|mint:MINT-7966010(identity)	mint:O88871|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004965"(G protein-coupled GABA receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0038039"(G protein-coupled receptor heterodimeric complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:1902710"(GABA receptor complex)|reactome:R-RNO-1296041|reactome:R-RNO-418594|reactome:R-RNO-420499|reactome:R-RNO-977444|reactome:R-RNO-997272|go:"GO:0005737"(cytoplasm)|interpro:IPR017978|refseq:NP_113990.1|rgd:619864|interpro:IPR017979|interpro:IPR028082|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR002455(GPCR, family 3, gamma-aminobutyric acid receptor, type B)|interpro:IPR002457(GPCR, family 3, gamma-aminobutyric acid receptor, type B2)|interpro:IPR041689|mint:MINT-7966009(identity)	-	comment:mint	comment:mint|function:"Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception"|comment:homomint	figure legend:f1d|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-hippocampus_neuron)|taxid:10116(Rattus norvegicus)	-	2010/07/07	2014/10/16	rogid:npFTYbblHdrM/cNG4TqjJ/u9kd010116	rogid:2KtIPgSLdOYAmc34lA/U+dOtAow10116	intact-crc:65BBCE1BE04E20E3|rigid:Yrsac1kRf5rhnp1bZqgO1WJHgjs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O88871	uniprotkb:P27732	intact:EBI-7090239|intact:MINT-1889821|uniprotkb:Q9QWU2|uniprotkb:Q9JK36	intact:EBI-8072674|uniprotkb:Q63491|uniprotkb:Q63492|uniprotkb:Q62691|uniprotkb:Q01542|uniprotkb:O09024|intact:MINT-7965882|uniprotkb:O09022|uniprotkb:Q62815|uniprotkb:O09023	psi-mi:gabr2_rat(display_long)|uniprotkb:Gabbr2(gene name)|psi-mi:Gabbr2(display_short)|uniprotkb:Gpr51(gene name synonym)|uniprotkb:G-protein coupled receptor 51(gene name synonym)	psi-mi:cac1d_rat(display_long)|uniprotkb:Cacna1d(gene name)|psi-mi:Cacna1d(display_short)|uniprotkb:Cach3(gene name synonym)|uniprotkb:Cacn4(gene name synonym)|uniprotkb:Cacnl1a2(gene name synonym)|uniprotkb:Cchl1a2(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.3(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 2(gene name synonym)|uniprotkb:Rat brain class D(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Park et al. (2010)	pubmed:20627102|imex:IM-15596|mint:MINT-7965874|doi:10.1016/j.febslet.2010.07.014	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8072727|mint:MINT-7966016|imex:IM-15596-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:O88871|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004965"(G protein-coupled GABA receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0038039"(G protein-coupled receptor heterodimeric complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:1902710"(GABA receptor complex)|reactome:R-RNO-1296041|reactome:R-RNO-418594|reactome:R-RNO-420499|reactome:R-RNO-977444|reactome:R-RNO-997272|go:"GO:0005737"(cytoplasm)|interpro:IPR017978|refseq:NP_113990.1|rgd:619864|interpro:IPR017979|interpro:IPR028082|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR002455(GPCR, family 3, gamma-aminobutyric acid receptor, type B)|interpro:IPR002457(GPCR, family 3, gamma-aminobutyric acid receptor, type B2)|interpro:IPR041689|mint:MINT-7966018(identity)	rgd:70973|refseq:NP_058994.1|dip:DIP-60740N|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904879"(positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005452(Voltage-dependent calcium channel, L-type, alpha-1D subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007613"(memory)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030506"(ankyrin binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060372"(regulation of atrial cardiac muscle cell membrane repolarization)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086007"(voltage-gated calcium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086059"(voltage-gated calcium channel activity involved SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098683"(cochlear hair cell ribbon synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|reactome:R-RNO-422356|mint:MINT-7966020(identity)	-	comment:mint|function:"Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception"|comment:homomint	comment:mint	figure legend:f1e|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-hippocampus_neuron)|taxid:10116(Rattus norvegicus)	-	2010/07/07	2014/10/16	rogid:2KtIPgSLdOYAmc34lA/U+dOtAow10116	rogid:npFTYbblHdrM/cNG4TqjJ/u9kd010116	intact-crc:9914040EF93FD237|rigid:Yrsac1kRf5rhnp1bZqgO1WJHgjs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O88871	uniprotkb:P27732	intact:EBI-7090239|intact:MINT-1889821|uniprotkb:Q9QWU2|uniprotkb:Q9JK36	intact:EBI-8072674|uniprotkb:Q63491|uniprotkb:Q63492|uniprotkb:Q62691|uniprotkb:Q01542|uniprotkb:O09024|intact:MINT-7965882|uniprotkb:O09022|uniprotkb:Q62815|uniprotkb:O09023	psi-mi:gabr2_rat(display_long)|uniprotkb:Gabbr2(gene name)|psi-mi:Gabbr2(display_short)|uniprotkb:Gpr51(gene name synonym)|uniprotkb:G-protein coupled receptor 51(gene name synonym)	psi-mi:cac1d_rat(display_long)|uniprotkb:Cacna1d(gene name)|psi-mi:Cacna1d(display_short)|uniprotkb:Cach3(gene name synonym)|uniprotkb:Cacn4(gene name synonym)|uniprotkb:Cacnl1a2(gene name synonym)|uniprotkb:Cchl1a2(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.3(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 2(gene name synonym)|uniprotkb:Rat brain class D(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Park et al. (2010)	pubmed:20627102|imex:IM-15596|mint:MINT-7965874|doi:10.1016/j.febslet.2010.07.014	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8072765|mint:MINT-7966026|imex:IM-15596-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:O88871|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004965"(G protein-coupled GABA receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0038039"(G protein-coupled receptor heterodimeric complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:1902710"(GABA receptor complex)|reactome:R-RNO-1296041|reactome:R-RNO-418594|reactome:R-RNO-420499|reactome:R-RNO-977444|reactome:R-RNO-997272|go:"GO:0005737"(cytoplasm)|interpro:IPR017978|refseq:NP_113990.1|rgd:619864|interpro:IPR017979|interpro:IPR028082|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR002455(GPCR, family 3, gamma-aminobutyric acid receptor, type B)|interpro:IPR002457(GPCR, family 3, gamma-aminobutyric acid receptor, type B2)|interpro:IPR041689|mint:MINT-7966028(identity)	rgd:70973|refseq:NP_058994.1|dip:DIP-60740N|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904879"(positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005452(Voltage-dependent calcium channel, L-type, alpha-1D subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007613"(memory)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030506"(ankyrin binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060372"(regulation of atrial cardiac muscle cell membrane repolarization)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086007"(voltage-gated calcium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086059"(voltage-gated calcium channel activity involved SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098683"(cochlear hair cell ribbon synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|reactome:R-RNO-422356|mint:MINT-7966030(identity)	go:"GO:0005886"(plasma membrane)	comment:mint|function:"Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception"|comment:homomint	comment:mint	figure legend:f3a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-hippocampus_neuron)|taxid:10116(Rattus norvegicus)	-	2010/07/07	2014/10/16	rogid:2KtIPgSLdOYAmc34lA/U+dOtAow10116	rogid:npFTYbblHdrM/cNG4TqjJ/u9kd010116	intact-crc:29D1EC11DDEB4CD5|rigid:Yrsac1kRf5rhnp1bZqgO1WJHgjs	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P27732	uniprotkb:O88871	intact:EBI-8072674|uniprotkb:Q63491|uniprotkb:Q63492|uniprotkb:Q62691|uniprotkb:Q01542|uniprotkb:O09024|intact:MINT-7965882|uniprotkb:O09022|uniprotkb:Q62815|uniprotkb:O09023	intact:EBI-7090239|intact:MINT-1889821|uniprotkb:Q9QWU2|uniprotkb:Q9JK36	psi-mi:cac1d_rat(display_long)|uniprotkb:Cacna1d(gene name)|psi-mi:Cacna1d(display_short)|uniprotkb:Cach3(gene name synonym)|uniprotkb:Cacn4(gene name synonym)|uniprotkb:Cacnl1a2(gene name synonym)|uniprotkb:Cchl1a2(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.3(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 2(gene name synonym)|uniprotkb:Rat brain class D(gene name synonym)	psi-mi:gabr2_rat(display_long)|uniprotkb:Gabbr2(gene name)|psi-mi:Gabbr2(display_short)|uniprotkb:Gpr51(gene name synonym)|uniprotkb:G-protein coupled receptor 51(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Park et al. (2010)	pubmed:20627102|imex:IM-15596|mint:MINT-7965874|doi:10.1016/j.febslet.2010.07.014	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8072787|mint:MINT-7975667|imex:IM-15596-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:70973|refseq:NP_058994.1|dip:DIP-60740N|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904879"(positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005452(Voltage-dependent calcium channel, L-type, alpha-1D subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007613"(memory)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030506"(ankyrin binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060372"(regulation of atrial cardiac muscle cell membrane repolarization)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086007"(voltage-gated calcium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086059"(voltage-gated calcium channel activity involved SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098683"(cochlear hair cell ribbon synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|reactome:R-RNO-422356|mint:MINT-7975671(identity)	mint:O88871|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004965"(G protein-coupled GABA receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0038039"(G protein-coupled receptor heterodimeric complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:1902710"(GABA receptor complex)|reactome:R-RNO-1296041|reactome:R-RNO-418594|reactome:R-RNO-420499|reactome:R-RNO-977444|reactome:R-RNO-997272|go:"GO:0005737"(cytoplasm)|interpro:IPR017978|refseq:NP_113990.1|rgd:619864|interpro:IPR017979|interpro:IPR028082|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR002455(GPCR, family 3, gamma-aminobutyric acid receptor, type B)|interpro:IPR002457(GPCR, family 3, gamma-aminobutyric acid receptor, type B2)|interpro:IPR041689|mint:MINT-7975669(identity)	-	comment:mint	comment:mint|function:"Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception"|comment:homomint	figure legend:f1a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2010/07/07	2014/10/16	rogid:npFTYbblHdrM/cNG4TqjJ/u9kd010116	rogid:2KtIPgSLdOYAmc34lA/U+dOtAow10116	intact-crc:BB83B0BA6F2BF620|rigid:Yrsac1kRf5rhnp1bZqgO1WJHgjs	false	fusion protein:?-?(MINT-7975681)|binding-associated region:1-151(MINT-7975683)	binding-associated region:?-?(MINT-7975688)|fusion protein:?-?(MINT-7975686)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P27732	uniprotkb:O88871	intact:EBI-8072674|uniprotkb:Q63491|uniprotkb:Q63492|uniprotkb:Q62691|uniprotkb:Q01542|uniprotkb:O09024|intact:MINT-7965882|uniprotkb:O09022|uniprotkb:Q62815|uniprotkb:O09023	intact:EBI-7090239|intact:MINT-1889821|uniprotkb:Q9QWU2|uniprotkb:Q9JK36	psi-mi:cac1d_rat(display_long)|uniprotkb:Cacna1d(gene name)|psi-mi:Cacna1d(display_short)|uniprotkb:Cach3(gene name synonym)|uniprotkb:Cacn4(gene name synonym)|uniprotkb:Cacnl1a2(gene name synonym)|uniprotkb:Cchl1a2(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.3(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 2(gene name synonym)|uniprotkb:Rat brain class D(gene name synonym)	psi-mi:gabr2_rat(display_long)|uniprotkb:Gabbr2(gene name)|psi-mi:Gabbr2(display_short)|uniprotkb:Gpr51(gene name synonym)|uniprotkb:G-protein coupled receptor 51(gene name synonym)	psi-mi:"MI:0096"(pull down)	Park et al. (2010)	pubmed:20627102|imex:IM-15596|mint:MINT-7965874|doi:10.1016/j.febslet.2010.07.014	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8072822|mint:MINT-7975691|imex:IM-15596-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:70973|refseq:NP_058994.1|dip:DIP-60740N|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904879"(positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005452(Voltage-dependent calcium channel, L-type, alpha-1D subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007613"(memory)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030506"(ankyrin binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060372"(regulation of atrial cardiac muscle cell membrane repolarization)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086007"(voltage-gated calcium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086059"(voltage-gated calcium channel activity involved SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098683"(cochlear hair cell ribbon synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|reactome:R-RNO-422356|mint:MINT-7975699(identity)	mint:O88871|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004965"(G protein-coupled GABA receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0038039"(G protein-coupled receptor heterodimeric complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:1902710"(GABA receptor complex)|reactome:R-RNO-1296041|reactome:R-RNO-418594|reactome:R-RNO-420499|reactome:R-RNO-977444|reactome:R-RNO-997272|go:"GO:0005737"(cytoplasm)|interpro:IPR017978|refseq:NP_113990.1|rgd:619864|interpro:IPR017979|interpro:IPR028082|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR002455(GPCR, family 3, gamma-aminobutyric acid receptor, type B)|interpro:IPR002457(GPCR, family 3, gamma-aminobutyric acid receptor, type B2)|interpro:IPR041689|mint:MINT-7975693(identity)	-	comment:mint	comment:mint|function:"Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception"|comment:homomint	figure legend:f1b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/07/07	2014/10/16	rogid:npFTYbblHdrM/cNG4TqjJ/u9kd010116	rogid:2KtIPgSLdOYAmc34lA/U+dOtAow10116	intact-crc:DFDB9AFEB20B8B24|rigid:Yrsac1kRf5rhnp1bZqgO1WJHgjs	false	binding-associated region:1-151(MINT-7975700)|glutathione s tranferase tag:?-?(MINT-7975702)	ha tag:?-?(MINT-7975696)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O88871	uniprotkb:P27732	intact:EBI-7090239|intact:MINT-1889821|uniprotkb:Q9QWU2|uniprotkb:Q9JK36	intact:EBI-8072674|uniprotkb:Q63491|uniprotkb:Q63492|uniprotkb:Q62691|uniprotkb:Q01542|uniprotkb:O09024|intact:MINT-7965882|uniprotkb:O09022|uniprotkb:Q62815|uniprotkb:O09023	psi-mi:gabr2_rat(display_long)|uniprotkb:Gabbr2(gene name)|psi-mi:Gabbr2(display_short)|uniprotkb:Gpr51(gene name synonym)|uniprotkb:G-protein coupled receptor 51(gene name synonym)	psi-mi:cac1d_rat(display_long)|uniprotkb:Cacna1d(gene name)|psi-mi:Cacna1d(display_short)|uniprotkb:Cach3(gene name synonym)|uniprotkb:Cacn4(gene name synonym)|uniprotkb:Cacnl1a2(gene name synonym)|uniprotkb:Cchl1a2(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.3(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 2(gene name synonym)|uniprotkb:Rat brain class D(gene name synonym)	psi-mi:"MI:0096"(pull down)	Park et al. (2010)	pubmed:20627102|imex:IM-15596|mint:MINT-7965874|doi:10.1016/j.febslet.2010.07.014	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8072843|mint:MINT-7975712|imex:IM-15596-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:O88871|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004965"(G protein-coupled GABA receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0038039"(G protein-coupled receptor heterodimeric complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:1902710"(GABA receptor complex)|reactome:R-RNO-1296041|reactome:R-RNO-418594|reactome:R-RNO-420499|reactome:R-RNO-977444|reactome:R-RNO-997272|go:"GO:0005737"(cytoplasm)|interpro:IPR017978|refseq:NP_113990.1|rgd:619864|interpro:IPR017979|interpro:IPR028082|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR002455(GPCR, family 3, gamma-aminobutyric acid receptor, type B)|interpro:IPR002457(GPCR, family 3, gamma-aminobutyric acid receptor, type B2)|interpro:IPR041689|mint:MINT-7975714(identity)	rgd:70973|refseq:NP_058994.1|dip:DIP-60740N|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904879"(positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005452(Voltage-dependent calcium channel, L-type, alpha-1D subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007613"(memory)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030506"(ankyrin binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060372"(regulation of atrial cardiac muscle cell membrane repolarization)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086007"(voltage-gated calcium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086059"(voltage-gated calcium channel activity involved SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098683"(cochlear hair cell ribbon synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|reactome:R-RNO-422356|mint:MINT-7975718(identity)	-	comment:mint|function:"Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception"|comment:homomint	comment:mint	figure legend:f1c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/07/07	2014/10/16	rogid:2KtIPgSLdOYAmc34lA/U+dOtAow10116	rogid:npFTYbblHdrM/cNG4TqjJ/u9kd010116	intact-crc:138E56D66372C4BF|rigid:Yrsac1kRf5rhnp1bZqgO1WJHgjs	false	-	binding-associated region:1-151(MINT-7975721)|glutathione s tranferase tag:?-?(MINT-7975719)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P27732	uniprotkb:O75899	intact:EBI-8072674|uniprotkb:Q63491|uniprotkb:Q63492|uniprotkb:Q62691|uniprotkb:Q01542|uniprotkb:O09024|intact:MINT-7965882|uniprotkb:O09022|uniprotkb:Q62815|uniprotkb:O09023	intact:EBI-715469|uniprotkb:O75974|uniprotkb:O75975|uniprotkb:Q5VXZ2|uniprotkb:Q8WX04|uniprotkb:Q9P1R2|uniprotkb:Q9UNR1|uniprotkb:Q9UNS9|ensembl:ENSP00000259455	psi-mi:cac1d_rat(display_long)|uniprotkb:Cacna1d(gene name)|psi-mi:Cacna1d(display_short)|uniprotkb:Cach3(gene name synonym)|uniprotkb:Cacn4(gene name synonym)|uniprotkb:Cacnl1a2(gene name synonym)|uniprotkb:Cchl1a2(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.3(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 2(gene name synonym)|uniprotkb:Rat brain class D(gene name synonym)	psi-mi:gabr2_human(display_long)|uniprotkb:G-protein coupled receptor 51(gene name synonym)|uniprotkb:HG20(gene name synonym)|uniprotkb:GABBR2(gene name)|psi-mi:GABBR2(display_short)|uniprotkb:GPR51(gene name synonym)|uniprotkb:GPRC3B(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Park et al. (2010)	pubmed:20627102|imex:IM-15596|mint:MINT-7965874|doi:10.1016/j.febslet.2010.07.014	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8072870|mint:MINT-7975740|imex:IM-15596-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:70973|refseq:NP_058994.1|dip:DIP-60740N|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904879"(positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005452(Voltage-dependent calcium channel, L-type, alpha-1D subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007613"(memory)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030001"(metal ion transport)|go:"GO:0030018"(Z disc)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030506"(ankyrin binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042383"(sarcolemma)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060372"(regulation of atrial cardiac muscle cell membrane repolarization)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086007"(voltage-gated calcium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086059"(voltage-gated calcium channel activity involved SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098683"(cochlear hair cell ribbon synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|reactome:R-RNO-422356|mint:MINT-7975745(identity)	refseq:NP_005449.5|ensembl:ENSG00000136928(gene)|ensembl:ENST00000259455(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004965"(G protein-coupled GABA receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0038039"(G protein-coupled receptor heterodimeric complex)|go:"GO:0043005"(neuron projection)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0150099"(neuron-glial cell signaling)|go:"GO:1902710"(GABA receptor complex)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR002455(GPCR, family 3, gamma-aminobutyric acid receptor, type B)|interpro:IPR002457(GPCR, family 3, gamma-aminobutyric acid receptor, type B2)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR041689|mint:O75899|rcsb pdb:4F11|rcsb pdb:4F12|rcsb pdb:4MQE|rcsb pdb:4MQF|rcsb pdb:4MR7|rcsb pdb:4MR8|rcsb pdb:4MR9|rcsb pdb:4MRM|rcsb pdb:4MS1|rcsb pdb:4MS3|rcsb pdb:4MS4|rcsb pdb:4PAS|rcsb pdb:6M8R|rcsb pdb:6OCP|rcsb pdb:6UO8|rcsb pdb:6UO9|rcsb pdb:6UOA|rcsb pdb:6VJM|rcsb pdb:6W2X|rcsb pdb:6WIV|rcsb pdb:7C7Q|rcsb pdb:7C7S|rcsb pdb:7CA3|rcsb pdb:7CA5|rcsb pdb:7CUM|rcsb pdb:7EB2|reactome:R-HSA-1296041|reactome:R-HSA-418594|reactome:R-HSA-420499|reactome:R-HSA-977444|reactome:R-HSA-997272|dip:DIP-42851N|mint:MINT-7975743(identity)	go:"GO:0005886"(plasma membrane)	comment:mint	-	figure legend:f2a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/07/07	2014/10/16	rogid:npFTYbblHdrM/cNG4TqjJ/u9kd010116	rogid:vJ8ADZ7mdufBs4z/z0Zy4TzN3Sw9606	intact-crc:49ED663A3D950C3C|rigid:M9Qgs4asLFNKbAgn7HciuR07xis	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)