#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P08050	uniprotkb:P08050	intact:EBI-476947|uniprotkb:Q53ZE1|ensembl:ENSRNOP00000001054	intact:EBI-476947|uniprotkb:Q53ZE1|ensembl:ENSRNOP00000001054	psi-mi:cxa1_rat(display_long)|uniprotkb:Gja1(gene name)|psi-mi:Gja1(display_short)|uniprotkb:Cxn-43(gene name synonym)|uniprotkb:Connexin-43(gene name synonym)|uniprotkb:Gap junction 43 kDa heart protein(gene name synonym)	psi-mi:cxa1_rat(display_long)|uniprotkb:Gja1(gene name)|psi-mi:Gja1(display_short)|uniprotkb:Cxn-43(gene name synonym)|uniprotkb:Connexin-43(gene name synonym)|uniprotkb:Gap junction 43 kDa heart protein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Moritani et al. (2010)	pubmed:20608976|imex:IM-15830|mint:MINT-7900665|mint:fj-10-0261.r1	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8061214|mint:MINT-7900670|imex:IM-15830-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032277"(negative regulation of gonadotropin secretion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034634"(glutathione transmembrane transporter activity)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0030165"(PDZ domain binding)|ensembl:ENSRNOT00000001054(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001764"(neuron migration)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|ensembl:ENSRNOG00000000805(gene)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002931"(response to ischemia)|go:"GO:0003104"(positive regulation of glomerular filtration)|go:"GO:0003158"(endothelium development)|go:"GO:0042311"(vasodilation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042908"(xenobiotic transport)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043292"(contractile fiber)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045121"(membrane raft)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045844"(positive regulation of striated muscle tissue development)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046697"(decidualization)|go:"GO:0046849"(bone remodeling)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055077"(gap junction hemi-channel activity)|go:"GO:0055085"(transmembrane transport)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060156"(milk ejection reflex)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0060348"(bone development)|go:"GO:0060371"(regulation of atrial cardiac muscle cell membrane depolarization)|go:"GO:0060373"(regulation of ventricular cardiac muscle cell membrane depolarization)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061337"(cardiac conduction)|go:"GO:0070160"(tight junction)|go:"GO:0071253"(connexin binding)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071467"(cellular response to pH)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0003294"(atrial ventricular junction remodeling)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005243"(gap junction channel activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905332"(positive regulation of morphogenesis of an epithelium)|go:"GO:1905772"(positive regulation of mesodermal cell differentiation)|go:"GO:0140115"(export across plasma membrane)|go:"GO:1905867"(epididymis development)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|go:"GO:2000987"(positive regulation of behavioral fear response)|interpro:IPR000500(Connexins)|go:"GO:1903763"(gap junction channel activity involved in cell communication by electrical coupling)|interpro:IPR002261("Gap junction alpha-1 protein (Cx43)")|interpro:IPR013092(Connexin, N-terminal)|interpro:IPR013124("Gap junction alpha-1 protein (Cx43), C-terminal")|interpro:IPR017990|interpro:IPR019570|interpro:IPR034634|interpro:IPR035091|interpro:IPR038359|mint:P08050|rcsb pdb:1R5S|rcsb pdb:2N8T|rcsb pdb:3CYY|reactome:R-RNO-190840|reactome:R-RNO-190861|reactome:R-RNO-190873|reactome:R-RNO-191650|reactome:R-RNO-196025|reactome:R-RNO-9013406|go:"GO:0005916"(fascia adherens)|go:"GO:0008584"(male gonad development)|go:"GO:0009268"(response to pH)|go:"GO:0005921"(gap junction)|go:"GO:0005922"(connexin complex)|go:"GO:0009749"(response to glucose)|go:"GO:0010232"(vascular transport)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010643"(cell communication by chemical coupling)|go:"GO:0010644"(cell communication by electrical coupling)|go:"GO:0010649"(regulation of cell communication by electrical coupling)|go:"GO:0010652"(positive regulation of cell communication by chemical coupling)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014704"(intercalated disc)|go:"GO:0015075"(ion transmembrane transporter activity)|go:"GO:0015562"(efflux transmembrane transporter activity)|go:"GO:0015631"(tubulin binding)|go:"GO:0015867"(ATP transport)|go:"GO:0016020"(membrane)|go:"GO:0016264"(gap junction assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0006915"(apoptotic process)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0007154"(cell communication)|go:"GO:0030054"(cell junction)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007507"(heart development)|go:"GO:0007512"(adult heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008285"(negative regulation of cell population proliferation)|rgd:2690|refseq:NP_036699.1|dip:DIP-34793N|mint:MINT-7900672(identity)	go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032277"(negative regulation of gonadotropin secretion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034634"(glutathione transmembrane transporter activity)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0030165"(PDZ domain binding)|ensembl:ENSRNOT00000001054(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001764"(neuron migration)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|ensembl:ENSRNOG00000000805(gene)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002931"(response to ischemia)|go:"GO:0003104"(positive regulation of glomerular filtration)|go:"GO:0003158"(endothelium development)|go:"GO:0042311"(vasodilation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042908"(xenobiotic transport)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043292"(contractile fiber)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045121"(membrane raft)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045844"(positive regulation of striated muscle tissue development)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046697"(decidualization)|go:"GO:0046849"(bone remodeling)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055077"(gap junction hemi-channel activity)|go:"GO:0055085"(transmembrane transport)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060156"(milk ejection reflex)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0060348"(bone development)|go:"GO:0060371"(regulation of atrial cardiac muscle cell membrane depolarization)|go:"GO:0060373"(regulation of ventricular cardiac muscle cell membrane depolarization)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061337"(cardiac conduction)|go:"GO:0070160"(tight junction)|go:"GO:0071253"(connexin binding)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071467"(cellular response to pH)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0003294"(atrial ventricular junction remodeling)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005243"(gap junction channel activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905332"(positive regulation of morphogenesis of an epithelium)|go:"GO:1905772"(positive regulation of mesodermal cell differentiation)|go:"GO:0140115"(export across plasma membrane)|go:"GO:1905867"(epididymis development)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|go:"GO:2000987"(positive regulation of behavioral fear response)|interpro:IPR000500(Connexins)|go:"GO:1903763"(gap junction channel activity involved in cell communication by electrical coupling)|interpro:IPR002261("Gap junction alpha-1 protein (Cx43)")|interpro:IPR013092(Connexin, N-terminal)|interpro:IPR013124("Gap junction alpha-1 protein (Cx43), C-terminal")|interpro:IPR017990|interpro:IPR019570|interpro:IPR034634|interpro:IPR035091|interpro:IPR038359|mint:P08050|rcsb pdb:1R5S|rcsb pdb:2N8T|rcsb pdb:3CYY|reactome:R-RNO-190840|reactome:R-RNO-190861|reactome:R-RNO-190873|reactome:R-RNO-191650|reactome:R-RNO-196025|reactome:R-RNO-9013406|go:"GO:0005916"(fascia adherens)|go:"GO:0008584"(male gonad development)|go:"GO:0009268"(response to pH)|go:"GO:0005921"(gap junction)|go:"GO:0005922"(connexin complex)|go:"GO:0009749"(response to glucose)|go:"GO:0010232"(vascular transport)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010643"(cell communication by chemical coupling)|go:"GO:0010644"(cell communication by electrical coupling)|go:"GO:0010649"(regulation of cell communication by electrical coupling)|go:"GO:0010652"(positive regulation of cell communication by chemical coupling)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014704"(intercalated disc)|go:"GO:0015075"(ion transmembrane transporter activity)|go:"GO:0015562"(efflux transmembrane transporter activity)|go:"GO:0015631"(tubulin binding)|go:"GO:0015867"(ATP transport)|go:"GO:0016020"(membrane)|go:"GO:0016264"(gap junction assembly)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0006915"(apoptotic process)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0007154"(cell communication)|go:"GO:0030054"(cell junction)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007507"(heart development)|go:"GO:0007512"(adult heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008285"(negative regulation of cell population proliferation)|rgd:2690|refseq:NP_036699.1|dip:DIP-34793N|mint:MINT-7900672(identity)	-	comment:"Stoichiometry: 6.0"	comment:"Stoichiometry: 6.0"	figure legend:f6a|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/07	2014/10/16	rogid:qRGPHCApRj9/xiPxo1KW9D/xE5w10116	rogid:qRGPHCApRj9/xiPxo1KW9D/xE5w10116	intact-crc:BDDC5752B91EBADC|rigid:c+0emDC2iMsqr2FwYNLe52cXHQQ	false	-	-	6	0	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)