#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P80204	uniprotkb:Q9Z340	intact:EBI-2899234	intact:EBI-349441|ensembl:ENSRNOP00000048964	psi-mi:tgfr1_rat(display_long)|uniprotkb:Tgfbr1(gene name)|psi-mi:Tgfbr1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)	psi-mi:pard3_rat(display_long)|uniprotkb:Pard3(gene name)|psi-mi:Pard3(display_short)|uniprotkb:Par3(gene name synonym)|uniprotkb:Atypical PKC isotype-specific-interacting protein(gene name synonym)|uniprotkb:Atypical PKC-specific-binding protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yi et al. (2010)	imex:IM-14952|pubmed:20603020	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2899229|imex:IM-14952-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048565"(digestive tract development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|refseq:XP_006238092.2|rgd:3852|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR000333(Activin type II receptor)|reactome:R-RNO-2173788|reactome:R-RNO-2173789|reactome:R-RNO-2173791|reactome:R-RNO-5689880	rgd:620374|refseq:NP_112514.1|ensembl:ENSRNOG00000032437(gene)|ensembl:ENSRNOT00000042623(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003383"(apical constriction)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032970"(regulation of actin filament-based process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033269"(internode region of axon)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043296"(apical junction complex)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045177"(apical part of cell)|go:"GO:0005912"(adherens junction)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0090162"(establishment of epithelial cell polarity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR021922|interpro:IPR036034|rcsb pdb:2K1Z|rcsb pdb:2K20|rcsb pdb:2NS5|rcsb pdb:2OGP|rcsb pdb:3ZEE|rcsb pdb:4DC2|rcsb pdb:4I6P|rcsb pdb:6JUE|reactome:R-RNO-2173791|reactome:R-RNO-420029|dip:DIP-33271N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 6E.|comment:Both Par6 and Par3 coimmunoprecipitated with TBR1 from E18 rat forebrain lysates, indicating that TBR1 and Par3/Par6 form a biochemical complex in developing brain.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-embryonic_forebrain)|taxid:10116(Rattus norvegicus embryonic forebrain)	-	2010/07/28	2014/10/16	rogid:jWHHsCqbR7534bJHrAPRv6mXRQM10116	rogid:pCIhxZdK3JRmJvgDmVgEtDI7fjc10116	intact-crc:D1B84F20ACB3817E|rigid:wHZm5Qoshwf2kIk6w9Ale96dDds	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P80204	uniprotkb:Q6B4M5	intact:EBI-2899234	intact:EBI-2899276|uniprotkb:Q4U4X0|uniprotkb:Q6B4M6	psi-mi:tgfr1_rat(display_long)|uniprotkb:Tgfbr1(gene name)|psi-mi:Tgfbr1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)	psi-mi:par6a_rat(display_long)|uniprotkb:Pard6a(gene name)|psi-mi:Pard6a(display_short)|uniprotkb:Par-6a(gene name synonym)|uniprotkb:Par6a(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yi et al. (2010)	imex:IM-14952|pubmed:20603020	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2899229|imex:IM-14952-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048565"(digestive tract development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|refseq:XP_006238092.2|rgd:3852|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR000333(Activin type II receptor)|reactome:R-RNO-2173788|reactome:R-RNO-2173789|reactome:R-RNO-2173791|reactome:R-RNO-5689880	go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045177"(apical part of cell)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034872|interpro:IPR036034|reactome:R-RNO-9013148|reactome:R-RNO-9013149|rgd:1303273|dip:DIP-46160N|reactome:R-RNO-2173791|reactome:R-RNO-420029|reactome:R-RNO-4608870	psi-mi:"MI:0469"(intact)	-	"mimix:comment":not sure about protein subtype, an alpha form was given by me	figure legend:Fig 6E.|comment:Both Par6 and Par3 coimmunoprecipitated with TBR1 from E18 rat forebrain lysates, indicating that TBR1 and Par3/Par6 form a biochemical complex in developing brain.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-embryonic_forebrain)|taxid:10116(Rattus norvegicus embryonic forebrain)	-	2010/07/28	2014/10/16	rogid:jWHHsCqbR7534bJHrAPRv6mXRQM10116	rogid:klcLP478a2W+MQWfA/bOUWqLEJU10116	intact-crc:D1B84F20ACB3817E|rigid:wHZm5Qoshwf2kIk6w9Ale96dDds	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61330	uniprotkb:Q62312	intact:EBI-774820|uniprotkb:Q6NZJ4|uniprotkb:Q7TSJ5|ensembl:ENSMUSP00000083707	intact:EBI-2899332|ensembl:ENSMUSP00000062333|uniprotkb:Q63947	psi-mi:cntn2_mouse(display_long)|uniprotkb:Axonin-1(gene name synonym)|uniprotkb:Axonal glycoprotein TAG-1(gene name synonym)|uniprotkb:Transient axonal glycoprotein 1(gene name synonym)|uniprotkb:Cntn2(gene name)|psi-mi:Cntn2(display_short)|uniprotkb:Tax(gene name synonym)	psi-mi:tgfr2_mouse(display_long)|uniprotkb:Tgfbr2(gene name)|psi-mi:Tgfbr2(display_short)|uniprotkb:Transforming growth factor-beta receptor type II(gene name synonym)|uniprotkb:TGF-beta type II receptor(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Yi et al. (2010)	imex:IM-14952|pubmed:20603020	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2899324|imex:IM-14952-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_796103.2|refseq:XP_006529425.1|ensembl:ENSMUSG00000053024(gene)|ensembl:ENSMUST00000086521(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0005886"(plasma membrane)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007612"(learning)|go:"GO:0007628"(adult walking behavior)|go:"GO:0009986"(cell surface)|go:"GO:0010769"(regulation of cell morphogenesis involved in differentiation)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0021853"(cerebral cortex GABAergic interneuron migration)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0031133"(regulation of axon diameter)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0033268"(node of Ranvier)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043621"(protein self-association)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0045163"(clustering of voltage-gated potassium channels)|go:"GO:0045202"(synapse)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048710"(regulation of astrocyte differentiation)|go:"GO:0060168"(positive regulation of adenosine receptor signaling pathway)|go:"GO:0071205"(protein localization to juxtaparanode region of axon)|go:"GO:0071206"(establishment of protein localization to juxtaparanode region of axon)|go:"GO:0097090"(presynaptic membrane organization)|go:"GO:0099025"(anchored component of postsynaptic membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:5E7L	go:"GO:0003430"(growth plate cartilage chondrocyte growth)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005026"(transforming growth factor beta receptor activity, type II)|go:"GO:0005524"(ATP binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030324"(lung development)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043235"(receptor complex)|go:"GO:0043415"(positive regulation of skeletal muscle tissue regeneration)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046332"(SMAD binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001947"(heart looping)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002651"(positive regulation of tolerance induction to self antigen)|go:"GO:0002663"(positive regulation of B cell tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003274"(endocardial cushion fusion)|ensembl:ENSMUSG00000032440(gene)|ensembl:ENSMUST00000061101(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:1990428"(miRNA transport)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015013(Transforming growth factor beta receptor 2 ectodomain)|interpro:IPR017194(Transforming growth factor-beta receptor, type II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q62312|reactome:R-MMU-2173788|reactome:R-MMU-2173789|reactome:R-MMU-2173791|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:0048185"(activin binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048565"(digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060433"(bronchus development)|go:"GO:0060434"(bronchus morphogenesis)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0062009"(secondary palate development)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905317"(inferior endocardial cushion morphogenesis)|go:"GO:0046872"(metal ion binding)|refseq:NP_033397.3|dip:DIP-44605N	go:"GO:0030424"(axon)	-	-	comment:"Simultaneously labelling of the cortex with an antibody for TBR2 and TAG1, (a marker of corticofugal axons) showed coincident immunoreactivity between TBR2 and TAG1."|figure legend:Fig 1 E+F.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neocortex)|taxid:10090(Mus musculus Neocortex)	-	2010/07/28	2014/10/16	rogid:p7ltfg6M5FhP58FVZo1iT1HKTwg10090	rogid:zO622M93E590ht8MhEJYcOigw2E10090	intact-crc:BF0496A1C35FC34D|rigid:sZsCuhXpgnN4DZtLO+qMKo57gmw	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q6P5H2	uniprotkb:Q64729	intact:EBI-2899462|ensembl:ENSMUSP00000088493|uniprotkb:A1E2I2|uniprotkb:Q80X00|uniprotkb:Q8BPH7|uniprotkb:Q9CV43|uniprotkb:Q9R0C4	intact:EBI-2899393|ensembl:ENSMUSP00000007757|uniprotkb:A2AJN0	psi-mi:nest_mouse(display_long)|uniprotkb:Nes(gene name)|psi-mi:Nes(display_short)	psi-mi:tgfr1_mouse(display_long)|uniprotkb:Tgfbr1(gene name)|psi-mi:Tgfbr1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:ESK2(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Yi et al. (2010)	imex:IM-14952|pubmed:20603020	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2899451|cell ontology:"CL:0000681"|imex:IM-14952-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUST00000090973(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030844"(positive regulation of intermediate filament depolymerization)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0048858"(cell projection morphogenesis)|ensembl:ENSMUSG00000004891(gene)|go:"GO:0072089"(stem cell proliferation)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR018039|interpro:IPR031211|interpro:IPR039008|refseq:NP_057910.3	ensembl:ENSMUSG00000007613(gene)|ensembl:ENSMUST00000007757(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0007399"(nervous system development)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0007507"(heart development)|go:"GO:0005524"(ATP binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q64729|reactome:R-MMU-2173788|reactome:R-MMU-2173789|reactome:R-MMU-2173791|reactome:R-MMU-5689880|refseq:NP_033396.1|refseq:NP_001299797.1|refseq:NP_001299798.1|dip:DIP-42262N	go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0045177"(apical part of cell)|go:"GO:0044225"(apical pole of neuron)	-	-	comment:Both TBR1 and TBR2 are highly expressed throughout the mouse neocortex, including nestin-positive radial glial progenitors. Both receptor types are present at apical domains of radial glia.|figure legend:Fig 1 A+B.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neocortex)|taxid:10090(Mus musculus Neocortex)	-	2010/07/28	2014/10/16	rogid:c9UQwTSScUEP6n41WzoQiEzEyN410090	rogid:FVbLT2jZx3h9oz+W89A7vrzJLGY10090	intact-crc:AEC6ADDB589E0D05|rigid:HiGdYsce4HU3y2yzhBIKdA0vLng	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q6P5H2	uniprotkb:Q62312	intact:EBI-2899462|ensembl:ENSMUSP00000088493|uniprotkb:A1E2I2|uniprotkb:Q80X00|uniprotkb:Q8BPH7|uniprotkb:Q9CV43|uniprotkb:Q9R0C4	intact:EBI-2899332|ensembl:ENSMUSP00000062333|uniprotkb:Q63947	psi-mi:nest_mouse(display_long)|uniprotkb:Nes(gene name)|psi-mi:Nes(display_short)	psi-mi:tgfr2_mouse(display_long)|uniprotkb:Tgfbr2(gene name)|psi-mi:Tgfbr2(display_short)|uniprotkb:Transforming growth factor-beta receptor type II(gene name synonym)|uniprotkb:TGF-beta type II receptor(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Yi et al. (2010)	imex:IM-14952|pubmed:20603020	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2899451|cell ontology:"CL:0000681"|imex:IM-14952-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUST00000090973(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030844"(positive regulation of intermediate filament depolymerization)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0048858"(cell projection morphogenesis)|ensembl:ENSMUSG00000004891(gene)|go:"GO:0072089"(stem cell proliferation)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR018039|interpro:IPR031211|interpro:IPR039008|refseq:NP_057910.3	go:"GO:0003430"(growth plate cartilage chondrocyte growth)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005026"(transforming growth factor beta receptor activity, type II)|go:"GO:0005524"(ATP binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030324"(lung development)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043235"(receptor complex)|go:"GO:0043415"(positive regulation of skeletal muscle tissue regeneration)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046332"(SMAD binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001947"(heart looping)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002651"(positive regulation of tolerance induction to self antigen)|go:"GO:0002663"(positive regulation of B cell tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003274"(endocardial cushion fusion)|ensembl:ENSMUSG00000032440(gene)|ensembl:ENSMUST00000061101(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:1990428"(miRNA transport)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015013(Transforming growth factor beta receptor 2 ectodomain)|interpro:IPR017194(Transforming growth factor-beta receptor, type II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q62312|reactome:R-MMU-2173788|reactome:R-MMU-2173789|reactome:R-MMU-2173791|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:0048185"(activin binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048565"(digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060433"(bronchus development)|go:"GO:0060434"(bronchus morphogenesis)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0062009"(secondary palate development)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905317"(inferior endocardial cushion morphogenesis)|go:"GO:0046872"(metal ion binding)|refseq:NP_033397.3|dip:DIP-44605N	go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0045177"(apical part of cell)|go:"GO:0044225"(apical pole of neuron)	-	-	comment:Both TBR1 and TBR2 are highly expressed throughout the mouse neocortex, including nestin-positive radial glial progenitors. Both receptor types are present at apical domains of radial glia.|figure legend:Fig 1 A+B.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neocortex)|taxid:10090(Mus musculus Neocortex)	-	2010/07/28	2014/10/16	rogid:c9UQwTSScUEP6n41WzoQiEzEyN410090	rogid:zO622M93E590ht8MhEJYcOigw2E10090	intact-crc:AEC6ADDB589E0D05|rigid:HiGdYsce4HU3y2yzhBIKdA0vLng	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q62312	uniprotkb:Q64729	intact:EBI-2899332|ensembl:ENSMUSP00000062333|uniprotkb:Q63947	intact:EBI-2899393|ensembl:ENSMUSP00000007757|uniprotkb:A2AJN0	psi-mi:tgfr2_mouse(display_long)|uniprotkb:Tgfbr2(gene name)|psi-mi:Tgfbr2(display_short)|uniprotkb:Transforming growth factor-beta receptor type II(gene name synonym)|uniprotkb:TGF-beta type II receptor(gene name synonym)	psi-mi:tgfr1_mouse(display_long)|uniprotkb:Tgfbr1(gene name)|psi-mi:Tgfbr1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:ESK2(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Yi et al. (2010)	imex:IM-14952|pubmed:20603020	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2899495|imex:IM-14952-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003430"(growth plate cartilage chondrocyte growth)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005026"(transforming growth factor beta receptor activity, type II)|go:"GO:0005524"(ATP binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030324"(lung development)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043235"(receptor complex)|go:"GO:0043415"(positive regulation of skeletal muscle tissue regeneration)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046332"(SMAD binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001947"(heart looping)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002651"(positive regulation of tolerance induction to self antigen)|go:"GO:0002663"(positive regulation of B cell tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003274"(endocardial cushion fusion)|ensembl:ENSMUSG00000032440(gene)|ensembl:ENSMUST00000061101(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:1990428"(miRNA transport)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015013(Transforming growth factor beta receptor 2 ectodomain)|interpro:IPR017194(Transforming growth factor-beta receptor, type II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q62312|reactome:R-MMU-2173788|reactome:R-MMU-2173789|reactome:R-MMU-2173791|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:0048185"(activin binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048565"(digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060433"(bronchus development)|go:"GO:0060434"(bronchus morphogenesis)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0062009"(secondary palate development)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905317"(inferior endocardial cushion morphogenesis)|go:"GO:0046872"(metal ion binding)|refseq:NP_033397.3|dip:DIP-44605N	ensembl:ENSMUSG00000007613(gene)|ensembl:ENSMUST00000007757(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0007399"(nervous system development)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0007507"(heart development)|go:"GO:0005524"(ATP binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q64729|reactome:R-MMU-2173788|reactome:R-MMU-2173789|reactome:R-MMU-2173791|reactome:R-MMU-5689880|refseq:NP_033396.1|refseq:NP_001299797.1|refseq:NP_001299798.1|dip:DIP-42262N	go:"GO:0043025"(neuronal cell body)	-	-	comment:"Both TBR1 and TBR2 were found in the cell bodies of layer 6 neurons, and diffuse TBR1 labeling was found within the intermediate zone (IZ) of the cortical wall."|figure legend:Fig 1 C+D.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neocortex)|taxid:10090(Mus musculus Neocortex)	-	2010/07/28	2014/10/16	rogid:zO622M93E590ht8MhEJYcOigw2E10090	rogid:FVbLT2jZx3h9oz+W89A7vrzJLGY10090	intact-crc:11DEC1AFD63C53F9|rigid:Z0DOdB0y7dDFpuNi5aORgZAB18k	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P80204	uniprotkb:P38438	intact:EBI-2899234	intact:EBI-2899543|ensembl:ENSRNOP00000035501	psi-mi:tgfr1_rat(display_long)|uniprotkb:Tgfbr1(gene name)|psi-mi:Tgfbr1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)	psi-mi:tgfr2_rat(display_long)|uniprotkb:Tgfbr2(gene name)|psi-mi:Tgfbr2(display_short)|uniprotkb:Transforming growth factor-beta receptor type II(gene name synonym)|uniprotkb:TGF-beta type II receptor(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Yi et al. (2010)	imex:IM-14952|pubmed:20603020	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2899539|imex:IM-14952-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048565"(digestive tract development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|refseq:XP_006238092.2|rgd:3852|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR000333(Activin type II receptor)|reactome:R-RNO-2173788|reactome:R-RNO-2173789|reactome:R-RNO-2173791|reactome:R-RNO-5689880	go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060433"(bronchus development)|go:"GO:0060434"(bronchus morphogenesis)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0062009"(secondary palate development)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905317"(inferior endocardial cushion morphogenesis)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990428"(miRNA transport)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015013(Transforming growth factor beta receptor 2 ectodomain)|interpro:IPR017194(Transforming growth factor-beta receptor, type II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-RNO-2173788|reactome:R-RNO-2173789|reactome:R-RNO-2173791|go:"GO:0050431"(transforming growth factor beta binding)|ensembl:ENSRNOG00000013265(gene)|ensembl:ENSRNOT00000037883(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001947"(heart looping)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002651"(positive regulation of tolerance induction to self antigen)|go:"GO:0002663"(positive regulation of B cell tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003274"(endocardial cushion fusion)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0003430"(growth plate cartilage chondrocyte growth)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005026"(transforming growth factor beta receptor activity, type II)|go:"GO:0005524"(ATP binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030324"(lung development)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043235"(receptor complex)|go:"GO:0043415"(positive regulation of skeletal muscle tissue regeneration)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046332"(SMAD binding)|go:"GO:0009749"(response to glucose)|go:"GO:0046872"(metal ion binding)|go:"GO:0048185"(activin binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048565"(digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|rgd:69651|refseq:NP_112394.3	go:"GO:0043005"(neuron projection)|go:"GO:0044295"(axonal growth cone)	-	-	comment:"Punctate distribution of TBR1 and TBR2 at the tips of all neurites can be seen in stage 2 cells prior to polarization.  By stage 3 (DIV4), TBR1and TBR2 were enriched within the within the growth cone of the axon and largely absent from dendrites."|figure legend:Fig 3 D-F.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-hippocampus)|taxid:10116(Rattus norvegicus hippocampal neurons)	-	2010/07/28	2014/10/16	rogid:jWHHsCqbR7534bJHrAPRv6mXRQM10116	rogid:bil36RLvdfS+tJU/0QjLX8jQ14010116	intact-crc:6EA04C9B793547DB|rigid:wLAw3wLHVtoFEMXSxdwi9iza2aE	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q6B4M5	uniprotkb:P80204	intact:EBI-2899276|uniprotkb:Q4U4X0|uniprotkb:Q6B4M6	intact:EBI-2899234	psi-mi:par6a_rat(display_long)|uniprotkb:Pard6a(gene name)|psi-mi:Pard6a(display_short)|uniprotkb:Par-6a(gene name synonym)|uniprotkb:Par6a(gene name synonym)	psi-mi:tgfr1_rat(display_long)|uniprotkb:Tgfbr1(gene name)|psi-mi:Tgfbr1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Yi et al. (2010)	imex:IM-14952|pubmed:20603020	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2899616|imex:IM-14952-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045177"(apical part of cell)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034872|interpro:IPR036034|reactome:R-RNO-9013148|reactome:R-RNO-9013149|rgd:1303273|dip:DIP-46160N|reactome:R-RNO-2173791|reactome:R-RNO-420029|reactome:R-RNO-4608870	go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048565"(digestive tract development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|refseq:XP_006238092.2|rgd:3852|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR000333(Activin type II receptor)|reactome:R-RNO-2173788|reactome:R-RNO-2173789|reactome:R-RNO-2173791|reactome:R-RNO-5689880	go:"GO:0030426"(growth cone)|go:"GO:0043005"(neuron projection)|go:"GO:0030175"(filopodium)	"mimix:comment":not sure about protein subtype, an alpha form was given by me	-	comment:In dissociated hippocampal neurons, surface TBR1 and Par6 colocalize in discrete punctate clusters within growth cones of undifferentiated neurites, particularly within filopodial protrusions.|figure legend:Fig 6 C+D.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-hippocampus)|taxid:10116(Rattus norvegicus hippocampal neurons)	-	2010/07/28	2014/10/16	rogid:klcLP478a2W+MQWfA/bOUWqLEJU10116	rogid:jWHHsCqbR7534bJHrAPRv6mXRQM10116	intact-crc:85D9B7DAE109F779|rigid:G44F2s5dVi/Hfcfu5nzy4lfl1HY	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q6P5H2	uniprotkb:Q9Z101	intact:EBI-2899462|ensembl:ENSMUSP00000088493|uniprotkb:A1E2I2|uniprotkb:Q80X00|uniprotkb:Q8BPH7|uniprotkb:Q9CV43|uniprotkb:Q9R0C4	intact:EBI-81732|uniprotkb:Q5RL03|uniprotkb:Q6P8R2|ensembl:ENSMUSP00000090886	psi-mi:nest_mouse(display_long)|uniprotkb:Nes(gene name)|psi-mi:Nes(display_short)	psi-mi:par6a_mouse(display_long)|uniprotkb:Pard6a(gene name)|psi-mi:Pard6a(display_short)|uniprotkb:Par6a(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Yi et al. (2010)	imex:IM-14952|pubmed:20603020	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2899602|cell ontology:"CL:0000681"|imex:IM-14952-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUST00000090973(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030844"(positive regulation of intermediate filament depolymerization)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0048858"(cell projection morphogenesis)|ensembl:ENSMUSG00000004891(gene)|go:"GO:0072089"(stem cell proliferation)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR018039|interpro:IPR031211|interpro:IPR039008|refseq:NP_057910.3	refseq:NP_001040900.1|refseq:NP_062669.2|ensembl:ENSMUSG00000005699(gene)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|ensembl:ENSMUST00000093195(transcript)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034872|interpro:IPR036034|reactome:R-MMU-2173791|reactome:R-MMU-420029|reactome:R-MMU-4608870|reactome:R-MMU-9013148|reactome:R-MMU-9013149|dip:DIP-32553N	go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0045177"(apical part of cell)	-	-	comment:Using antibody labeled brain slices from E18 mouse embryos  both Par6 and TBR1 are enriched within apical domains of radial glia in the VZ.|figure legend:Fig 6 A+B.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neocortex)|taxid:10090(Mus musculus Neocortex)	-	2010/07/28	2014/10/16	rogid:c9UQwTSScUEP6n41WzoQiEzEyN410090	rogid:gmmbxc9dNybdFr3Tf6e8lN5H/vQ10090	intact-crc:5E8C698B16BEE569|rigid:iLk1MBx3gZeEKzjV0hsCnOdNiEM	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q6P5H2	uniprotkb:Q64729	intact:EBI-2899462|ensembl:ENSMUSP00000088493|uniprotkb:A1E2I2|uniprotkb:Q80X00|uniprotkb:Q8BPH7|uniprotkb:Q9CV43|uniprotkb:Q9R0C4	intact:EBI-2899393|ensembl:ENSMUSP00000007757|uniprotkb:A2AJN0	psi-mi:nest_mouse(display_long)|uniprotkb:Nes(gene name)|psi-mi:Nes(display_short)	psi-mi:tgfr1_mouse(display_long)|uniprotkb:Tgfbr1(gene name)|psi-mi:Tgfbr1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:ESK2(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Yi et al. (2010)	imex:IM-14952|pubmed:20603020	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2899602|cell ontology:"CL:0000681"|imex:IM-14952-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUST00000090973(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030844"(positive regulation of intermediate filament depolymerization)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0048858"(cell projection morphogenesis)|ensembl:ENSMUSG00000004891(gene)|go:"GO:0072089"(stem cell proliferation)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR018039|interpro:IPR031211|interpro:IPR039008|refseq:NP_057910.3	ensembl:ENSMUSG00000007613(gene)|ensembl:ENSMUST00000007757(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0007399"(nervous system development)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0007507"(heart development)|go:"GO:0005524"(ATP binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q64729|reactome:R-MMU-2173788|reactome:R-MMU-2173789|reactome:R-MMU-2173791|reactome:R-MMU-5689880|refseq:NP_033396.1|refseq:NP_001299797.1|refseq:NP_001299798.1|dip:DIP-42262N	go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0045177"(apical part of cell)	-	-	comment:Using antibody labeled brain slices from E18 mouse embryos  both Par6 and TBR1 are enriched within apical domains of radial glia in the VZ.|figure legend:Fig 6 A+B.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-neocortex)|taxid:10090(Mus musculus Neocortex)	-	2010/07/28	2014/10/16	rogid:c9UQwTSScUEP6n41WzoQiEzEyN410090	rogid:FVbLT2jZx3h9oz+W89A7vrzJLGY10090	intact-crc:5E8C698B16BEE569|rigid:iLk1MBx3gZeEKzjV0hsCnOdNiEM	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)