#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8IZP0	uniprotkb:P27986	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8049189|mint:MINT-7907815|imex:IM-15587-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7907816(identity)|uniprotkb:Q8IZP0(original identifier)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N|mint:MINT-7907823(identity)|uniprotkb:P27986(original identifier)	-	-	-	comment:homomint|comment:domino|comment:mint|figure legend:sf3 f3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:120.9x10^-9(molar)	2010/06/18	2014/10/16	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	intact-crc:A4E7A4E87E76A785|rigid:r1E+4dzf+zR4uakYicQRz1hXNVE	false	mutation disrupting interaction:213-213(MINT-7908644)|phosphorylated residue:213-213(MINT-7907821)|binding-associated region:207-220(MINT-7907819)	binding-associated region:333-428(MINT-7907826)|glutathione s tranferase tag:?-?(MINT-7907829)	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)
uniprotkb:P27986	uniprotkb:Q8IZP0	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8049223|mint:MINT-7907832|imex:IM-15587-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N|mint:MINT-7907840(identity)|uniprotkb:P27986(original identifier)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7907833(identity)|uniprotkb:Q8IZP0(original identifier)	-	-	-	comment:homomint|comment:domino|comment:mint|figure legend:sf3 f3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:606.3x10^-9(molar)	2010/06/18	2014/10/16	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	intact-crc:EE68FAE71942EC0E|rigid:r1E+4dzf+zR4uakYicQRz1hXNVE	false	binding-associated region:624-718(MINT-7907843)|glutathione s tranferase tag:?-?(MINT-7907846)	phosphorylated residue:213-213(MINT-7907838)|binding-associated region:207-220(MINT-7907836)|mutation disrupting interaction:213-213(MINT-7908637)	-	-	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:P27986	uniprotkb:Q8IZP0	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8049257|mint:MINT-7907848|imex:IM-15587-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N|mint:MINT-7907856(identity)|uniprotkb:P27986(original identifier)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7907849(identity)|uniprotkb:Q8IZP0(original identifier)	-	-	-	comment:homomint|comment:domino|comment:mint|figure legend:f1b sf1 sf3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:134.8x10^-9(molar)	2010/06/18	2014/10/16	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	intact-crc:30D92E02D0EF0010|rigid:r1E+4dzf+zR4uakYicQRz1hXNVE	false	glutathione s tranferase tag:?-?(MINT-7907862)|binding-associated region:333-718(MINT-7907859)	phosphorylated residue:213-213(MINT-7907854)|binding-associated region:207-220(MINT-7907852)|mutation disrupting interaction:213-213(MINT-7908633)	-	-	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:P27986	uniprotkb:Q8IZP0	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8049291|mint:MINT-7907865|imex:IM-15587-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N|mint:MINT-7907873(identity)|uniprotkb:P27986(original identifier)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7907866(identity)|uniprotkb:Q8IZP0(original identifier)	-	-	-	comment:homomint|comment:domino|comment:mint|figure legend:sf3 f3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:109.7x10^-9(molar)	2010/06/18	2014/10/16	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	intact-crc:4B27BB425DD9D1B7|rigid:r1E+4dzf+zR4uakYicQRz1hXNVE	false	glutathione s tranferase tag:?-?(MINT-7907879)|binding-associated region:333-428(MINT-7907876)	binding-associated region:412-425(MINT-7907869)|phosphorylated residue:421-421(MINT-7907871)	-	-	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:P27986	uniprotkb:Q8IZP0	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8049337|mint:MINT-7907881|imex:IM-15587-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N|mint:MINT-7907889(identity)|uniprotkb:P27986(original identifier)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7907882(identity)|uniprotkb:Q8IZP0(original identifier)	-	-	-	comment:homomint|comment:domino|comment:mint|figure legend:f1b sf1 sf3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:240.6x10^-9(molar)	2010/06/18	2014/10/16	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	intact-crc:06094A8C5EE9AFBA|rigid:r1E+4dzf+zR4uakYicQRz1hXNVE	false	glutathione s tranferase tag:?-?(MINT-7907895)|binding-associated region:333-718(MINT-7907892)	binding-associated region:412-425(MINT-7907885)|phosphorylated residue:421-421(MINT-7907887)	-	-	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q8IZP0	uniprotkb:P27986	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8049366|mint:MINT-7907897|imex:IM-15587-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7907898(identity)|uniprotkb:Q8IZP0(original identifier)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N|mint:MINT-7907905(identity)|uniprotkb:P27986(original identifier)	-	-	-	comment:homomint|comment:domino|comment:mint|figure legend:sf3 f3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:184.7x10^-9(molar)	2010/06/18	2014/10/16	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	intact-crc:BAF7587274500CAA|rigid:r1E+4dzf+zR4uakYicQRz1hXNVE	false	binding-associated region:493-508(MINT-7907901)|phosphorylated residue:506-506(MINT-7907903)	binding-associated region:333-428(MINT-7907908)|glutathione s tranferase tag:?-?(MINT-7907911)	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)
uniprotkb:Q8IZP0	uniprotkb:P27986	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8049432|mint:MINT-7907929|imex:IM-15587-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7907930(identity)|uniprotkb:Q8IZP0(original identifier)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N|mint:MINT-7907937(identity)|uniprotkb:P27986(original identifier)	-	-	-	comment:homomint|figure legend:sf3|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	intact-crc:F8A90150666B9049|rigid:r1E+4dzf+zR4uakYicQRz1hXNVE	false	phosphorylated residue:506-506(MINT-7907935)|binding-associated region:493-508(MINT-7907933)	binding-associated region:333-718(MINT-7907940)|glutathione s tranferase tag:?-?(MINT-7907943)	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)
uniprotkb:P27986	uniprotkb:Q8IZP0	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8049395|mint:MINT-7907913|imex:IM-15587-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N|mint:MINT-7907921(identity)|uniprotkb:P27986(original identifier)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7907914(identity)|uniprotkb:Q8IZP0(original identifier)	-	-	-	comment:homomint|comment:domino|comment:mint|figure legend:sf3 f3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:495.2x10^-9(molar)	2010/06/18	2014/10/16	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	intact-crc:F1BEB67D10454721|rigid:r1E+4dzf+zR4uakYicQRz1hXNVE	false	binding-associated region:624-718(MINT-7907924)|glutathione s tranferase tag:?-?(MINT-7907927)	binding-associated region:493-508(MINT-7907917)|phosphorylated residue:506-506(MINT-7907919)	-	-	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q8IZP0	uniprotkb:P06241	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	intact:EBI-515315|uniprotkb:Q16248|uniprotkb:Q5R3A6|uniprotkb:Q5R3A7|uniprotkb:Q8N5D7|uniprotkb:B5BU57|intact:EBI-2561531|uniprotkb:E1P557|uniprotkb:H0UI48|ensembl:ENSP00000346671|ensembl:ENSP00000357656	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:fyn_human(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)|uniprotkb:Src-like kinase(gene name synonym)|uniprotkb:FYN(gene name)|psi-mi:FYN(display_short)|uniprotkb:Proto-oncogene Syn(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8049509|mint:MINT-7907962|imex:IM-15587-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7907963(identity)|uniprotkb:Q8IZP0(original identifier)	refseq:XP_005266947.1|refseq:XP_005266949.1|refseq:NP_002028.1|refseq:NP_694592.1|refseq:NP_694593.1|refseq:XP_016866139.1|refseq:XP_016866140.1|refseq:XP_016866141.1|refseq:XP_016866142.1|refseq:XP_016866143.1|dip:DIP-33876N|ensembl:ENSG00000010810(gene)|ensembl:ENST00000354650(transcript)|ensembl:ENST00000368667(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001764"(neuron migration)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0003015"(heart process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007612"(learning)|go:"GO:0007631"(feeding behavior)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|interpro:IPR036028|interpro:IPR036860|mint:P06241|rcsb pdb:1A0N|rcsb pdb:1AOT|rcsb pdb:1AOU|rcsb pdb:1AVZ|rcsb pdb:1AZG|rcsb pdb:1EFN|rcsb pdb:1FYN|rcsb pdb:1G83|rcsb pdb:1M27|rcsb pdb:1NYF|rcsb pdb:1NYG|rcsb pdb:1SHF|rcsb pdb:1ZBJ|rcsb pdb:2DQ7|rcsb pdb:2MQI|rcsb pdb:2MRJ|rcsb pdb:2MRK|rcsb pdb:3H0F|rcsb pdb:3H0H|rcsb pdb:3H0I|rcsb pdb:3UA6|rcsb pdb:3UA7|rcsb pdb:4D8D|rcsb pdb:4EIK|rcsb pdb:4U17|rcsb pdb:4U1P|rcsb pdb:4ZNX|rcsb pdb:5ZAU|rcsb pdb:6EDF|rcsb pdb:6IPY|rcsb pdb:6IPZ|reactome:R-HSA-114604|reactome:R-HSA-1227986|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-399956|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5621480|reactome:R-HSA-5621575|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-75892|reactome:R-HSA-8866376|reactome:R-HSA-9032500|reactome:R-HSA-9032759|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9706374|reactome:R-HSA-983695|reactome:R-HSA-9670439|mint:MINT-7907970(identity)|uniprotkb:P06241(original identifier)	-	-	-	comment:homomint|comment:domino|comment:mint|figure legend:sf1 f1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:108.2x10^-9(molar)	2010/06/18	2014/10/16	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	rogid:GM5wIXENkJgPKwHN+UZBIqUfH6U9606	intact-crc:52381F8F9A479C08|rigid:FD10fpghstuE4//wJkv4NjZrmPs	false	phosphorylated residue:421-421(MINT-7907968)|binding-associated region:207-220(MINT-7907966)	glutathione s tranferase tag:?-?(MINT-7907976)|binding-associated region:149-246(MINT-7907973)	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)
uniprotkb:P00519	uniprotkb:Q8IZP0	intact:EBI-375543|uniprotkb:Q13869|uniprotkb:Q13870|uniprotkb:Q16133|uniprotkb:Q45F09|ensembl:ENSP00000323315|uniprotkb:A3KFJ3|uniprotkb:Q17R61|intact:EBI-1550796	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	psi-mi:abl1_human(display_long)|uniprotkb:Abelson tyrosine-protein kinase 1(gene name synonym)|uniprotkb:ABL1(gene name)|psi-mi:ABL1(display_short)|uniprotkb:ABL(gene name synonym)|uniprotkb:JTK7(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 1(gene name synonym)|uniprotkb:Proto-oncogene c-Abl(gene name synonym)|uniprotkb:p150(gene name synonym)	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8049480|mint:MINT-7907945|imex:IM-15587-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005148.2|refseq:NP_009297.2|ensembl:ENSG00000097007(gene)|ensembl:ENST00000318560(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016301"(kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019905"(syntaxin binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030035"(microspike assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002333"(transitional one stage B cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004515"(nicotinate-nucleotide adenylyltransferase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0038191"(neuropilin binding)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048668"(collateral sprouting)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071103"(DNA conformation change)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072359"(circulatory system development)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090135"(actin filament branching)|go:"GO:0098794"(postsynapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900275"(negative regulation of phospholipase C activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1903053"(regulation of extracellular matrix organization)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015015(F-actin binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR033221|interpro:IPR035837|interpro:IPR036028|interpro:IPR036860|mint:P00519|rcsb pdb:1AB2|rcsb pdb:1ABL|rcsb pdb:2HIW|rcsb pdb:2HYY|rcsb pdb:2HZ0|rcsb pdb:2HZ4|rcsb pdb:2HZI|rcsb pdb:2O88|rcsb pdb:2V7A|rcsb pdb:3CS9|rcsb pdb:3EG0|rcsb pdb:3EG1|rcsb pdb:3EG2|rcsb pdb:3EG3|rcsb pdb:3EGU|rcsb pdb:3K2M|rcsb pdb:3PYY|rcsb pdb:3QRI|rcsb pdb:3QRJ|rcsb pdb:3QRK|rcsb pdb:3T04|rcsb pdb:3UE4|rcsb pdb:3UYO|rcsb pdb:4J9B|rcsb pdb:4J9C|rcsb pdb:4J9D|rcsb pdb:1AWO|rcsb pdb:1BBZ|rcsb pdb:1JU5|rcsb pdb:1OPL|rcsb pdb:1ZZP|rcsb pdb:2ABL|rcsb pdb:2E2B|rcsb pdb:2F4J|rcsb pdb:2FO0|rcsb pdb:4J9E|rcsb pdb:2G1T|rcsb pdb:4J9F|rcsb pdb:2G2F|rcsb pdb:2G2H|rcsb pdb:4J9G|rcsb pdb:2G2I|rcsb pdb:4J9H|rcsb pdb:2GQG|rcsb pdb:4J9I|rcsb pdb:4JJB|rcsb pdb:4JJC|rcsb pdb:4JJD|rcsb pdb:4TWP|rcsb pdb:4WA9|rcsb pdb:4XEY|rcsb pdb:4YC8|rcsb pdb:4ZOG|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5HU9|rcsb pdb:5MO4|rcsb pdb:5NP2|rcsb pdb:5OAZ|rcsb pdb:6AMV|rcsb pdb:6AMW|rcsb pdb:6BL8|rcsb pdb:6NPE|rcsb pdb:6NPU|rcsb pdb:6NPV|rcsb pdb:6XR6|rcsb pdb:6XR7|rcsb pdb:6XRG|rcsb pdb:7CC2|rcsb pdb:7DT2|reactome:R-HSA-2029482|reactome:R-HSA-428890|reactome:R-HSA-525793|reactome:R-HSA-5663213|reactome:R-HSA-5685938|reactome:R-HSA-5693565|reactome:R-HSA-69231|reactome:R-HSA-8939236|reactome:R-HSA-8940973|reactome:R-HSA-9664422|reactome:R-HSA-983231|dip:DIP-1042N|mint:MINT-7907953(identity)|uniprotkb:P00519(original identifier)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7907946(identity)|uniprotkb:Q8IZP0(original identifier)	-	-	-	comment:homomint|comment:domino|comment:mint|figure legend:f1b sf1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1259.0x10^-9(molar)	2010/06/18	2014/10/16	rogid:t7dT+fWrrK2QaWF4U0HQaVgHKUc9606	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	intact-crc:FF4FA51EA6B30127|rigid:WfUmYFFNKQ6IIHK17kcx2uuL2SY	false	binding-associated region:127-217(MINT-7907956)|glutathione s tranferase tag:?-?(MINT-7907959)	phosphorylated residue:213-213(MINT-7907951)|binding-associated region:207-220(MINT-7907949)	-	-	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q8IZP0	uniprotkb:P06239	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	intact:EBI-1348|uniprotkb:P07100|uniprotkb:Q12850|uniprotkb:Q13152|uniprotkb:Q5TDH8|uniprotkb:Q5TDH9|uniprotkb:Q96DW4|uniprotkb:Q9NYT8|ensembl:ENSP00000337825|ensembl:ENSP00000477713|uniprotkb:Q7RTZ3|uniprotkb:D3DPP8	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:lck_human(display_long)|uniprotkb:Protein YT16(gene name synonym)|uniprotkb:Proto-oncogene Lck(gene name synonym)|uniprotkb:T cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:LCK(gene name)|psi-mi:LCK(display_short)|uniprotkb:Lymphocyte cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:p56-LCK(gene name synonym)|uniprotkb:Leukocyte C-terminal Src kinase(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8049840|mint:MINT-7908027|imex:IM-15587-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908028(identity)|uniprotkb:Q8IZP0(original identifier)	refseq:NP_001036236.1|refseq:NP_005347.3|ensembl:ENSG00000182866(gene)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|ensembl:ENST00000336890(transcript)|ensembl:ENST00000619559(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|dip:DIP-553N|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051249"(regulation of lymphocyte activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|mint:P06239|rcsb pdb:1BHF|rcsb pdb:1BHH|rcsb pdb:1CWD|rcsb pdb:1CWE|rcsb pdb:1FBZ|rcsb pdb:1H92|rcsb pdb:1IJR|rcsb pdb:1KIK|rcsb pdb:1LCJ|rcsb pdb:1LCK|rcsb pdb:1LKK|rcsb pdb:1LKL|rcsb pdb:1Q68|rcsb pdb:1Q69|rcsb pdb:1QPC|rcsb pdb:1QPD|rcsb pdb:1QPE|rcsb pdb:1QPJ|rcsb pdb:1X27|rcsb pdb:2IIM|rcsb pdb:2OF2|rcsb pdb:2OF4|rcsb pdb:2OFU|rcsb pdb:2OFV|rcsb pdb:2OG8|rcsb pdb:2PL0|rcsb pdb:2ZM1|rcsb pdb:2ZM4|rcsb pdb:2ZYB|rcsb pdb:3AC1|rcsb pdb:3AC2|rcsb pdb:3AC3|rcsb pdb:3AC4|rcsb pdb:3AC5|rcsb pdb:3AC8|rcsb pdb:3ACJ|rcsb pdb:3ACK|rcsb pdb:3AD4|rcsb pdb:3AD5|rcsb pdb:3AD6|rcsb pdb:3B2W|rcsb pdb:3BRH|rcsb pdb:3BYM|rcsb pdb:3BYO|rcsb pdb:3BYS|rcsb pdb:3BYU|rcsb pdb:3KMM|rcsb pdb:3KXZ|rcsb pdb:3LCK|rcsb pdb:3MPM|rcsb pdb:4C3F|rcsb pdb:4D8K|rcsb pdb:5MTM|rcsb pdb:5MTN|rcsb pdb:6H6A|rcsb pdb:6PDJ|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-167590|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-389948|reactome:R-HSA-6811558|reactome:R-HSA-9013407|reactome:R-HSA-9020558|reactome:R-HSA-9670439|reactome:R-HSA-9706374|mint:MINT-7908035(identity)|uniprotkb:P06239(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	rogid:AIdRYIcSNXmD2ovQiEn9N4CWr/M9606	intact-crc:6948C6F9E12C78DD|rigid:obknMLMkKfB+v+CkrDYM3uuOnUM	false	phosphorylated residue:421-421(MINT-7908033)|binding-associated region:412-425(MINT-7908031)	binding-associated region:127-224(MINT-7908038)|glutathione s tranferase tag:?-?(MINT-7908041)	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)
uniprotkb:Q8IZP0	uniprotkb:P52735	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8049868|mint:MINT-7908043|imex:IM-15587-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908044(identity)|uniprotkb:Q8IZP0(original identifier)	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N|mint:MINT-7908051(identity)|uniprotkb:P52735(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	intact-crc:1564A00499C28C65|rigid:kFiOh7yROZop/IBgjHSFKuZ7hS4	false	binding-associated region:412-425(MINT-7908047)|phosphorylated residue:421-421(MINT-7908049)	glutathione s tranferase tag:?-?(MINT-7908057)|binding-associated region:673-767(MINT-7908054)	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)
uniprotkb:P42685	uniprotkb:Q8IZP0	intact:EBI-1383583|uniprotkb:Q13128|uniprotkb:Q9NTR5|uniprotkb:B4DY49|ensembl:ENSP00000476145	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	psi-mi:frk_human(display_long)|uniprotkb:PTK5(gene name synonym)|uniprotkb:RAK(gene name synonym)|uniprotkb:FYN-related kinase(gene name synonym)|uniprotkb:Nuclear tyrosine protein kinase RAK(gene name synonym)|uniprotkb:FRK(gene name)|psi-mi:FRK(display_short)|uniprotkb:Protein-tyrosine kinase 5(gene name synonym)	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8049896|mint:MINT-7908059|imex:IM-15587-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002022.1|refseq:XP_005266937.1|refseq:XP_005266938.1|refseq:XP_005266939.1|refseq:XP_011533955.1|refseq:XP_011533956.1|refseq:XP_011533957.1|refseq:XP_016866134.1|ensembl:ENST00000606080(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0045087"(innate immune response)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035805|interpro:IPR036028|interpro:IPR036860|mint:P42685|reactome:R-HSA-6798695|reactome:R-HSA-8948751|ensembl:ENSG00000111816(gene)|mint:MINT-7908067(identity)|uniprotkb:P42685(original identifier)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908060(identity)|uniprotkb:Q8IZP0(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:WP3N8FqRu6wIouk2iA0zJ1qmDRw9606	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	intact-crc:115DA6745637D408|rigid:g//wLCIQEnHOgUVJ1uTq+O3+1fc	false	glutathione s tranferase tag:?-?(MINT-7908073)|binding-associated region:116-208(MINT-7908070)	phosphorylated residue:421-421(MINT-7908065)|binding-associated region:412-425(MINT-7908063)	-	-	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:P09769	uniprotkb:Q8IZP0	intact:EBI-1383732|uniprotkb:Q9UIQ3|uniprotkb:D3DPL7|ensembl:ENSP00000363115|ensembl:ENSP00000363116|ensembl:ENSP00000363117|ensembl:ENSP00000382126	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	psi-mi:fgr_human(display_long)|uniprotkb:SRC2(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)|uniprotkb:FGR(gene name)|psi-mi:FGR(display_short)|uniprotkb:p55-Fgr(gene name synonym)|uniprotkb:"Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog"(gene name synonym)|uniprotkb:p58-Fgr(gene name synonym)|uniprotkb:p58c-Fgr(gene name synonym)	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8049924|mint:MINT-7908075|imex:IM-15587-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001036194.1|refseq:NP_001036212.1|refseq:XP_006710515.1|refseq:NP_005239.1|refseq:XP_011539312.1|dip:DIP-1049N|ensembl:ENSG00000000938(gene)|ensembl:ENST00000374003(transcript)|ensembl:ENST00000374004(transcript)|ensembl:ENST00000374005(transcript)|ensembl:ENST00000399173(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009615"(response to virus)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016235"(aggresome)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035693|interpro:IPR036028|interpro:IPR036860|mint:P09769|reactome:R-HSA-2029481|reactome:R-HSA-432142|reactome:R-HSA-6798695|reactome:R-HSA-9664323|reactome:R-HSA-9664422|mint:MINT-7908083(identity)|uniprotkb:P09769(original identifier)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908076(identity)|uniprotkb:Q8IZP0(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:rRgt5ZNh4lZSDL7R3neLMgDna2I9606	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	intact-crc:438FC01491AC5603|rigid:Lmss1ofIyDWwsGvA8V9TiuBT7eQ	false	glutathione s tranferase tag:?-?(MINT-7908089)|binding-associated region:144-241(MINT-7908086)	binding-associated region:412-425(MINT-7908079)|phosphorylated residue:421-421(MINT-7908081)	-	-	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q8IZP0	uniprotkb:P07947	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	intact:EBI-515331|uniprotkb:A6NLB3|uniprotkb:D3DUH1|intact:EBI-28995389|ensembl:ENSP00000324740|ensembl:ENSP00000462468	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:yes_human(display_long)|uniprotkb:p61-Yes(gene name synonym)|uniprotkb:Proto-oncogene c-Yes(gene name synonym)|uniprotkb:YES1(gene name)|psi-mi:YES1(display_short)|uniprotkb:YES(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8049970|mint:MINT-7908091|imex:IM-15587-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908092(identity)|uniprotkb:Q8IZP0(original identifier)	refseq:XP_016881449.1|refseq:NP_005424.1|ensembl:ENSP00000324740|ensembl:ENSP00000462468|dip:DIP-33849N|ensembl:ENSG00000176105(gene)|ensembl:ENST00000314574(transcript)|ensembl:ENST00000584307(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035751|interpro:IPR036028|interpro:IPR036860|mint:P07947|rcsb pdb:2HDA|reactome:R-HSA-1227986|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2682334|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-8940973|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9670439|mint:MINT-7908099(identity)|uniprotkb:P07947(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	rogid:Wo+NWxPVSmF8W6ZHQmTPpg3YuY09606	intact-crc:F5CAA13C983E4FB3|rigid:gb9d+utMOCg2x6Y4GdTvF26ibhk	false	phosphorylated residue:421-421(MINT-7908097)|binding-associated region:412-425(MINT-7908095)	glutathione s tranferase tag:?-?(MINT-7908105)|binding-associated region:158-255(MINT-7908102)	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)
uniprotkb:Q8IZP0	uniprotkb:P08631	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	intact:EBI-346340|uniprotkb:Q29RX1|uniprotkb:Q2VPE2|uniprotkb:Q504R5|uniprotkb:Q5T7K1|uniprotkb:Q5T7K2|uniprotkb:Q96CC0|uniprotkb:Q9H5Y5|uniprotkb:Q9NUA4|uniprotkb:Q9UMJ5|uniprotkb:B4DQB6|uniprotkb:E1P5M2|uniprotkb:A8K1I1|ensembl:ENSP00000365012	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:hck_human(display_long)|uniprotkb:HCK(gene name)|psi-mi:HCK(display_short)|uniprotkb:Hemopoietic cell kinase(gene name synonym)|uniprotkb:p59-HCK/p60-HCK(gene name synonym)|uniprotkb:Hematopoietic cell kinase(gene name synonym)|uniprotkb:p59Hck(gene name synonym)|uniprotkb:p61Hck(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8049998|mint:MINT-7908107|imex:IM-15587-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908108(identity)|uniprotkb:Q8IZP0(original identifier)	refseq:NP_001165600.1|refseq:NP_001165601.1|refseq:NP_001165602.1|refseq:NP_001165604.1|refseq:NP_002101.2|dip:DIP-1051N|ensembl:ENSG00000101336(gene)|ensembl:ENST00000375852(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002522"(leukocyte migration involved in immune response)|go:"GO:0002758"(innate immune response-activating signal transduction)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007498"(mesoderm development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030133"(transport vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043299"(leukocyte degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0046777"(protein autophosphorylation)|rcsb pdb:3VS3|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0071801"(regulation of podosome assembly)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035851|interpro:IPR036028|interpro:IPR036860|mint:P08631|rcsb pdb:1AD5|rcsb pdb:1BU1|rcsb pdb:1QCF|rcsb pdb:2C0I|rcsb pdb:2C0O|rcsb pdb:2C0T|rcsb pdb:2HCK|rcsb pdb:2HK5|rcsb pdb:2OI3|rcsb pdb:2OJ2|rcsb pdb:3HCK|rcsb pdb:3NHN|rcsb pdb:3RBB|rcsb pdb:3REA|rcsb pdb:3VS4|rcsb pdb:3VS5|rcsb pdb:3REB|rcsb pdb:3VS6|rcsb pdb:3VRY|rcsb pdb:3VRZ|rcsb pdb:3VS0|rcsb pdb:3VS1|rcsb pdb:3VS2|rcsb pdb:3VS7|rcsb pdb:4HCK|rcsb pdb:4LUD|rcsb pdb:4LUE|rcsb pdb:4ORZ|rcsb pdb:4U5W|rcsb pdb:5H09|rcsb pdb:5H0B|rcsb pdb:5H0G|rcsb pdb:5H0H|rcsb pdb:5HCK|rcsb pdb:5H0E|rcsb pdb:5NUH|rcsb pdb:5ZJ6|reactome:R-HSA-164944|reactome:R-HSA-2029481|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9706374|mint:MINT-7908115(identity)|uniprotkb:P08631(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	rogid:0ppUsdZNQdUtoKG6MdfS1bzOgZc9606	intact-crc:7537503F93884B31|rigid:au7DhxiknjfV1d0ntArLxwkOoSQ	false	phosphorylated residue:421-421(MINT-7908113)|binding-associated region:412-425(MINT-7908111)	binding-associated region:144-241(MINT-7908118)|glutathione s tranferase tag:?-?(MINT-7908121)	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)
uniprotkb:Q8IZP0	uniprotkb:P16591	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	intact:EBI-1380661|uniprotkb:B4DSQ2|uniprotkb:B2RCR4|uniprotkb:H2FLB8|ensembl:ENSP00000281092	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:fer_human(display_long)|uniprotkb:Feline encephalitis virus-related kinase FER(gene name synonym)|uniprotkb:Fujinami poultry sarcoma/Feline sarcoma-related protein Fer(gene name synonym)|uniprotkb:FER(gene name)|psi-mi:FER(display_short)|uniprotkb:TYK3(gene name synonym)|uniprotkb:Proto-oncogene c-Fer(gene name synonym)|uniprotkb:Tyrosine kinase 3(gene name synonym)|uniprotkb:p94-Fer(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8050026|mint:MINT-7908123|imex:IM-15587-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908124(identity)|uniprotkb:Q8IZP0(original identifier)	refseq:NP_005237.2|refseq:XP_016864719.1|refseq:XP_016864720.1|refseq:NP_001294957.1|refseq:NP_001294960.1|refseq:NP_001294967.1|refseq:XP_011541573.1|ensembl:ENSG00000151422(gene)|ensembl:ENST00000281092(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033007"(negative regulation of mast cell activation involved in immune response)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:0036119"(response to platelet-derived growth factor)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038109"(Kit signaling pathway)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042995"(cell projection)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050904"(diapedesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016250(Tyrosine-protein kinase, Fes/Fps)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027267|interpro:IPR028539|interpro:IPR031160|interpro:IPR035849|interpro:IPR036860|interpro:IPR037452|mint:P16591|rcsb pdb:2KK6|rcsb pdb:6KC4|reactome:R-HSA-1433557|mint:MINT-7908131(identity)|uniprotkb:P16591(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	rogid:De5RYVRGihPHGxaflmxR8W9jC8M9606	intact-crc:0CC9370CA2E6EAD2|rigid:gCK5gP/t0N+TNvVL7B2DPm1YkY0	false	phosphorylated residue:421-421(MINT-7908129)|binding-associated region:412-425(MINT-7908127)	binding-associated region:460-550(MINT-7908134)|glutathione s tranferase tag:?-?(MINT-7908137)	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)
uniprotkb:Q8IZP0	uniprotkb:O14512	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	intact:EBI-1539606|uniprotkb:A2VCU2|uniprotkb:Q0IJ63|ensembl:ENSP00000480736|ensembl:ENSP00000499750	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:socs7_human(display_long)|uniprotkb:SOCS7(gene name)|psi-mi:SOCS7(display_short)|uniprotkb:NAP4(gene name synonym)|uniprotkb:SOCS6(gene name synonym)|uniprotkb:Nck, Ash and phospholipase C gamma-binding protein(gene name synonym)|uniprotkb:Nck-associated protein 4(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8050071|mint:MINT-7908139|imex:IM-15587-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908140(identity)|uniprotkb:Q8IZP0(original identifier)	refseq:NP_055413.1|ensembl:ENSG00000274211(gene)|ensembl:ENSG00000274229(gene)|ensembl:ENST00000615473(transcript)|ensembl:ENST00000665913(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028423|interpro:IPR035866|interpro:IPR036036|interpro:IPR036860|interpro:IPR037346|mint:MINT-7908147(identity)|uniprotkb:O14512(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	rogid:MbBKOLby106g9tDOvy4FhIG6lgY9606	intact-crc:F4794D06097462D7|rigid:7ZT/qlwY931rwUhR47Ppt2Hjuv8	false	binding-associated region:412-425(MINT-7908143)|phosphorylated residue:421-421(MINT-7908145)	binding-associated region:400-509(MINT-7908150)|glutathione s tranferase tag:?-?(MINT-7908153)	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)
uniprotkb:P06241-2	uniprotkb:Q8IZP0	intact:EBI-8050137|intact:MINT-4990957|ensembl:ENSP00000357667|ensembl:ENSP00000357671|ensembl:ENSP00000440646	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	psi-mi:p06241-2(display_long)|uniprotkb:FYN(gene name)|psi-mi:FYN(display_short)|uniprotkb:Proto-oncogene Syn(gene name synonym)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)|uniprotkb:Src-like kinase(gene name synonym)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:T(isoform synonym)	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8050130|mint:MINT-7908155|imex:IM-15587-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-515315(isoform-parent)|uniprotkb:P06241-2(isoform-parent)|ensembl:ENSG00000010810(gene)|ensembl:ENST00000368678(transcript)|ensembl:ENST00000368682(transcript)|ensembl:ENST00000538466(transcript)|mint:MINT-7908163(identity)|uniprotkb:P06241-2(original identifier)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908156(identity)|uniprotkb:Q8IZP0(original identifier)	-	comment:mint	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:h8VaUfUV70ooukii6EUr1yzeIcg9606	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	intact-crc:BACC32B7D15D445A|rigid:2+kZnrHh5Jyi4TfLtjOPfz+pMss	false	binding-associated region:149-246(MINT-7908166)|glutathione s tranferase tag:?-?(MINT-7908169)	binding-associated region:412-425(MINT-7908159)|phosphorylated residue:421-421(MINT-7908161)	-	-	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:P07332	uniprotkb:Q8IZP0	intact:EBI-1055635|uniprotkb:B4DUD0|uniprotkb:E9PC94|uniprotkb:E9PC95|uniprotkb:Q2VXS7|uniprotkb:Q2VXS8|uniprotkb:Q2VXT0|uniprotkb:Q6GTU5|uniprotkb:B2R6E6|ensembl:ENSP00000331504	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	psi-mi:fes_human(display_long)|uniprotkb:FES(gene name)|psi-mi:FES(display_short)|uniprotkb:FPS(gene name synonym)|uniprotkb:Proto-oncogene c-Fes(gene name synonym)|uniprotkb:Proto-oncogene c-Fps(gene name synonym)|uniprotkb:Feline sarcoma/Fujinami avian sarcoma oncogene homolog(gene name synonym)|uniprotkb:p93c-fes(gene name synonym)	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8050199|mint:MINT-7908171|imex:IM-15587-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001137255.1|refseq:NP_001137256.1|refseq:NP_001137257.1|refseq:NP_001996.1|refseq:XP_005254937.1|refseq:XP_005254939.1|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016250(Tyrosine-protein kinase, Fes/Fps)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027267|interpro:IPR031160|interpro:IPR035849|interpro:IPR036860|mint:P07332|rcsb pdb:1WQU|rcsb pdb:2DCR|rcsb pdb:3BKB|rcsb pdb:3CBL|rcsb pdb:3CD3|rcsb pdb:4DYL|rcsb pdb:4E93|rcsb pdb:6JMF|reactome:R-HSA-1433557|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-399956|ensembl:ENSG00000182511(gene)|ensembl:ENST00000328850(transcript)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|refseq:XP_016877494.1|refseq:XP_016877495.1|refseq:XP_016877496.1|refseq:XP_016877497.1|refseq:XP_016877498.1|refseq:XP_016877499.1|mint:MINT-7908179(identity)|uniprotkb:P07332(original identifier)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908172(identity)|uniprotkb:Q8IZP0(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:jsI2Ytqu7whZlUt7qISAW3W3WqQ9606	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	intact-crc:5267155814438890|rigid:7pzXNp/rhnPNmNIOHB2pRNU95/w	false	glutathione s tranferase tag:?-?(MINT-7908185)|binding-associated region:460-549(MINT-7908182)	phosphorylated residue:421-421(MINT-7908177)|binding-associated region:412-425(MINT-7908175)	-	-	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q8IZP0	uniprotkb:P20936	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8050227|mint:MINT-7908187|imex:IM-15587-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908188(identity)|uniprotkb:Q8IZP0(original identifier)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N|mint:MINT-7908195(identity)|uniprotkb:P20936(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	intact-crc:092502FC91A0759C|rigid:V5ZkhqD2hS3wyFOOz4Ezo2VNX3E	false	phosphorylated residue:421-421(MINT-7908193)|binding-associated region:412-425(MINT-7908191)	binding-associated region:181-441(MINT-7908198)|glutathione s tranferase tag:?-?(MINT-7908201)	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)
uniprotkb:P12931	uniprotkb:Q8IZP0	intact:EBI-621482|intact:EBI-28966850|ensembl:ENSP00000350941|ensembl:ENSP00000362668|ensembl:ENSP00000362680|uniprotkb:Q86VB9|uniprotkb:Q9H5A8|intact:EBI-1383910|uniprotkb:Q76P87|uniprotkb:E1P5V4	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	psi-mi:src_human(display_long)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:SRC1(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8050301|mint:MINT-7908203|imex:IM-15587-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000350941|ensembl:ENST00000373558|ensembl:ENSP00000362659|ensembl:ENSP00000362668|ensembl:ENSP00000362680|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0034332"(adherens junction organization)|ensembl:ENSG00000197122(gene)|ensembl:ENST00000358208(transcript)|ensembl:ENST00000373567(transcript)|ensembl:ENST00000373578(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903997"(positive regulation of non-membrane spanning protein tyrosine kinase activity)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P12931|rcsb pdb:1A07|rcsb pdb:1A08|rcsb pdb:1A09|rcsb pdb:1A1A|rcsb pdb:1A1B|rcsb pdb:1A1C|rcsb pdb:1A1E|rcsb pdb:1FMK|rcsb pdb:1HCS|rcsb pdb:1HCT|rcsb pdb:1KSW|rcsb pdb:1O41|rcsb pdb:1O42|rcsb pdb:1O43|rcsb pdb:1O44|rcsb pdb:1O45|rcsb pdb:1O46|rcsb pdb:1O47|rcsb pdb:1O49|rcsb pdb:1O4A|rcsb pdb:1O4B|rcsb pdb:1O4C|rcsb pdb:1O4D|rcsb pdb:1O4E|rcsb pdb:1O4F|rcsb pdb:1O4G|rcsb pdb:1O4H|rcsb pdb:1O4I|rcsb pdb:1O4J|rcsb pdb:1O4K|rcsb pdb:1O4L|rcsb pdb:1O4M|rcsb pdb:1O4N|rcsb pdb:1O4O|rcsb pdb:1O4P|rcsb pdb:1O4Q|rcsb pdb:1O4R|rcsb pdb:1O48|rcsb pdb:1Y57|rcsb pdb:1YI6|rcsb pdb:1YOJ|rcsb pdb:1YOL|rcsb pdb:1YOM|rcsb pdb:2BDF|rcsb pdb:2BDJ|rcsb pdb:2H8H|rcsb pdb:2SRC|rcsb pdb:3VRO|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:4F59|rcsb pdb:4F5A|rcsb pdb:4F5B|rcsb pdb:4HXJ|rcsb pdb:4K11|rcsb pdb:4MXO|rcsb pdb:4MXX|rcsb pdb:4MXY|rcsb pdb:4MXZ|rcsb pdb:6ATE|rcsb pdb:6C4S|rcsb pdb:6E6E|rcsb pdb:6EHJ|reactome:R-HSA-1227986|reactome:R-HSA-1251985|reactome:R-HSA-1253288|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-171007|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-186763|reactome:R-HSA-191650|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2682334|reactome:R-HSA-354192|reactome:R-HSA-354194|rcsb pdb:1SHD|reactome:R-HSA-372708|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-391160|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418885|reactome:R-HSA-418886|reactome:R-HSA-428542|reactome:R-HSA-430116|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-456926|reactome:R-HSA-5218921|reactome:R-HSA-5607764|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-389513|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-69231|reactome:R-HSA-8853659|reactome:R-HSA-8874081|reactome:R-HSA-8876493|reactome:R-HSA-8934593|reactome:R-HSA-8934903|reactome:R-HSA-8940973|reactome:R-HSA-8941858|reactome:R-HSA-9009391|reactome:R-HSA-9032500|reactome:R-HSA-9603381|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9664323|refseq:NP_005408.1|refseq:NP_938033.1|refseq:XP_011527315.1|refseq:XP_016883513.1|refseq:XP_016883514.1|refseq:XP_016883515.1|refseq:XP_016883516.1|dip:DIP-1059N|mint:MINT-7908211(identity)|uniprotkb:P12931(original identifier)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908204(identity)|uniprotkb:Q8IZP0(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:8INdbX0tGHvmmiPKAw60bvecJAg9606	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	intact-crc:8B61006E9AC051B6|rigid:WZdGp9N/i09Zv9VtB+WTaCp052A	false	glutathione s tranferase tag:?-?(MINT-7908217)|binding-associated region:151-248(MINT-7908214)	binding-associated region:412-425(MINT-7908207)|phosphorylated residue:421-421(MINT-7908209)	-	-	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:P00523	uniprotkb:Q8IZP0	intact:EBI-848039|uniprotkb:Q90992|uniprotkb:Q90993|uniprotkb:Q91343|uniprotkb:Q91345|uniprotkb:Q92013|uniprotkb:Q98915|ensembl:ENSGALP00000049896|ensembl:ENSGALP00000054990|ensembl:ENSGALP00000068298	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	psi-mi:src_chick(display_long)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8050329|mint:MINT-7908219|imex:IM-15587-26	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_990788.2|dip:DIP-449N|refseq:XP_015151834.1|ensembl:ENSGALG00000003855(gene)|ensembl:ENSGALT00000061823(transcript)|ensembl:ENSGALT00000070498(transcript)|ensembl:ENSGALT00000093274(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0020037"(heme binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036035"(osteoclast development)|go:"GO:0045087"(innate immune response)|go:"GO:0045453"(bone resorption)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071253"(connexin binding)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P00523|rcsb pdb:1F1W|rcsb pdb:1F2F|rcsb pdb:1NLO|rcsb pdb:1NLP|rcsb pdb:1P13|rcsb pdb:1PRL|rcsb pdb:1PRM|rcsb pdb:1RLP|rcsb pdb:1RLQ|rcsb pdb:1SRL|rcsb pdb:1SRM|rcsb pdb:2HWO|rcsb pdb:2HWP|rcsb pdb:2OIQ|rcsb pdb:2PTK|rcsb pdb:2QI8|rcsb pdb:2QLQ|rcsb pdb:2QQ7|rcsb pdb:3D7T|rcsb pdb:3D7U|rcsb pdb:3DQW|rcsb pdb:3DQX|rcsb pdb:3EL7|rcsb pdb:3EL8|rcsb pdb:3EN4|rcsb pdb:3EN5|rcsb pdb:3EN6|rcsb pdb:3EN7|rcsb pdb:3F3T|rcsb pdb:3F3U|rcsb pdb:3F3V|rcsb pdb:3F3W|rcsb pdb:3F6X|rcsb pdb:3FJ5|rcsb pdb:3G5D|rcsb pdb:3G6G|rcsb pdb:3G6H|rcsb pdb:3GEQ|rcsb pdb:3LOK|rcsb pdb:3OEZ|rcsb pdb:3OF0|rcsb pdb:3QLF|rcsb pdb:3QLG|rcsb pdb:3SVV|rcsb pdb:3TZ7|rcsb pdb:3TZ8|rcsb pdb:3TZ9|rcsb pdb:3U4W|rcsb pdb:3U51|rcsb pdb:3UQF|rcsb pdb:3UQG|rcsb pdb:4AGW|rcsb pdb:4DGG|rcsb pdb:4FIC|rcsb pdb:4HVU|rcsb pdb:4HVV|rcsb pdb:4HVW|rcsb pdb:4JZ3|rcsb pdb:4JZ4|rcsb pdb:4LE9|rcsb pdb:4LGG|rcsb pdb:4LGH|rcsb pdb:4MCV|rcsb pdb:4O2P|rcsb pdb:4OML|rcsb pdb:4OMM|rcsb pdb:4OMN|rcsb pdb:4OMO|rcsb pdb:4OMP|rcsb pdb:4OMQ|rcsb pdb:4QT7|rcsb pdb:4RTU|rcsb pdb:4RTV|rcsb pdb:4RTW|rcsb pdb:4RTX|rcsb pdb:4RTY|rcsb pdb:4RTZ|rcsb pdb:4U5J|rcsb pdb:4YBJ|rcsb pdb:4YBK|rcsb pdb:5BMM|rcsb pdb:5D10|rcsb pdb:5D11|rcsb pdb:5D12|rcsb pdb:5EC7|rcsb pdb:5ECA|rcsb pdb:5I11|rcsb pdb:5J5S|rcsb pdb:5K9I|rcsb pdb:5OAV|rcsb pdb:5OB0|rcsb pdb:5OB1|rcsb pdb:5OB2|rcsb pdb:5SWH|rcsb pdb:5SYS|rcsb pdb:5T0P|rcsb pdb:5TEH|rcsb pdb:5XP5|rcsb pdb:5XP7|rcsb pdb:6HVE|rcsb pdb:6HVF|rcsb pdb:6L8L|rcsb pdb:6WIW|rcsb pdb:6XVM|rcsb pdb:6XVN|rcsb pdb:6XVO|rcsb pdb:6XX2|rcsb pdb:6XX3|rcsb pdb:6XX4|rcsb pdb:6XX5|reactome:R-GGA-1227986|reactome:R-GGA-1251985|reactome:R-GGA-1253288|reactome:R-GGA-1257604|reactome:R-GGA-1433557|reactome:R-GGA-180292|reactome:R-GGA-186763|reactome:R-GGA-191650|reactome:R-GGA-2029481|reactome:R-GGA-210990|reactome:R-GGA-354192|reactome:R-GGA-354194|reactome:R-GGA-372708|reactome:R-GGA-389356|reactome:R-GGA-389513|reactome:R-GGA-3928662|reactome:R-GGA-3928663|reactome:R-GGA-3928664|reactome:R-GGA-3928665|reactome:R-GGA-418592|reactome:R-GGA-418594|reactome:R-GGA-418885|reactome:R-GGA-430116|reactome:R-GGA-437239|reactome:R-GGA-4420097|reactome:R-GGA-456926|reactome:R-GGA-5218921|reactome:R-GGA-5674135|reactome:R-GGA-6811558|reactome:R-GGA-8853659|reactome:R-GGA-8874081|reactome:R-GGA-8941858|reactome:R-GGA-9009391|mint:MINT-7908227(identity)|uniprotkb:P00523(original identifier)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908220(identity)|uniprotkb:Q8IZP0(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:4zMmRUOi44prLCXBJNuTuFIMkr49031	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	intact-crc:4F9E8BAE11875AE6|rigid:0pkmMVkVQ193Dz3wfvGezbX5awc	false	binding-associated region:148-245(MINT-7908230)|glutathione s tranferase tag:?-?(MINT-7908233)	binding-associated region:412-425(MINT-7908223)|phosphorylated residue:421-421(MINT-7908225)	-	-	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:P07948	uniprotkb:Q8IZP0	intact:EBI-79452|ensembl:ENSP00000428924|uniprotkb:A0AVQ5|intact:EBI-6868890	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	psi-mi:lyn_human(display_long)|uniprotkb:JTK8(gene name synonym)|uniprotkb:Lck/Yes-related novel protein tyrosine kinase(gene name synonym)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)|uniprotkb:LYN(gene name)|psi-mi:LYN(display_short)	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8050357|mint:MINT-7908235|imex:IM-15587-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001104567.1|refseq:NP_002341.1|ensembl:ENSG00000254087(gene)|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983695|reactome:R-HSA-9664323|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|ensembl:ENST00000519728(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016301"(kinase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032868"(response to insulin)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P07948|rcsb pdb:1W1F|rcsb pdb:1WA7|go:"GO:0099091"(postsynaptic specialization, intracellular component)|rcsb pdb:5XY1|rcsb pdb:6NMW|reactome:R-HSA-114604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2454202|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-5621480|rcsb pdb:3A4O|reactome:R-HSA-5621575|reactome:R-HSA-5690714|reactome:R-HSA-69231|reactome:R-HSA-75892|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|reactome:R-HSA-912631|refseq:XP_016868905.1|dip:DIP-1056N|mint:MINT-7908243(identity)|uniprotkb:P07948(original identifier)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908236(identity)|uniprotkb:Q8IZP0(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:SqXPSC+g2ZuGHy6TAPV4HcpXe6U9606	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	intact-crc:5E8BD0531E76E0AA|rigid:lX2tnEDksiB9mnrFZkt53fKA3KQ	false	binding-associated region:129-226(MINT-7908246)|glutathione s tranferase tag:?-?(MINT-7908249)	phosphorylated residue:421-421(MINT-7908241)|binding-associated region:412-425(MINT-7908239)	-	-	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q8IZP0	uniprotkb:P19174	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	intact:EBI-79387|uniprotkb:Q2V575|uniprotkb:B9EGH4|uniprotkb:B7ZLY7|uniprotkb:E1P5W4|intact:EBI-3959906|ensembl:ENSP00000362368	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:plcg1_human(display_long)|uniprotkb:PLC-148(gene name synonym)|uniprotkb:PLC1(gene name synonym)|uniprotkb:Phospholipase C-II(gene name synonym)|uniprotkb:PLCG1(gene name)|psi-mi:PLCG1(display_short)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8050385|mint:MINT-7908251|imex:IM-15587-28	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908252(identity)|uniprotkb:Q8IZP0(original identifier)	refseq:NP_002651.2|refseq:NP_877963.1|dip:DIP-100N|ensembl:ENSG00000124181(gene)|ensembl:ENST00000373271(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042995"(cell projection)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR035724|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P19174|rcsb pdb:1HSQ|rcsb pdb:2HSP|rcsb pdb:4EY0|rcsb pdb:4FBN|rcsb pdb:7NXE|reactome:R-HSA-1169408|reactome:R-HSA-1236382|reactome:R-HSA-1251932|reactome:R-HSA-1489509|reactome:R-HSA-167021|reactome:R-HSA-1855204|reactome:R-HSA-186763|reactome:R-HSA-202433|reactome:R-HSA-2029485|reactome:R-HSA-210990|reactome:R-HSA-212718|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-418890|reactome:R-HSA-5218921|reactome:R-HSA-5637810|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-9026527|reactome:R-HSA-9027277|reactome:R-HSA-9034793|reactome:R-HSA-9664323|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|mint:MINT-7908259(identity)|uniprotkb:P19174(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	rogid:pJsNLrqg3cUj0SdjoyLf+/91yBo9606	intact-crc:FD046C12CE7E647E|rigid:59jUpkmu6seI5A92/faVMmWTUlY	false	binding-associated region:412-425(MINT-7908255)|phosphorylated residue:421-421(MINT-7908257)	binding-associated region:550-851(MINT-7908262)|glutathione s tranferase tag:?-?(MINT-7908265)	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)
uniprotkb:Q13322	uniprotkb:Q8IZP0	intact:EBI-80275|uniprotkb:O00427|uniprotkb:O00701|uniprotkb:O75222|uniprotkb:Q92606|uniprotkb:Q92907|uniprotkb:Q92948|intact:EBI-1760363|ensembl:ENSP00000381793|ensembl:ENSP00000385770|intact:EBI-1965437|uniprotkb:A7VJ95|uniprotkb:A4D258|uniprotkb:A8K0E6|uniprotkb:D3DVM9	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	psi-mi:grb10_human(display_long)|uniprotkb:GRB10(gene name)|psi-mi:GRB10(display_short)|uniprotkb:GRBIR(gene name synonym)|uniprotkb:KIAA0207(gene name synonym)|uniprotkb:GRB10 adapter protein(gene name synonym)|uniprotkb:Insulin receptor-binding protein Grb-IR(gene name synonym)	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8050430|mint:MINT-7908267|imex:IM-15587-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904738"(vascular associated smooth muscle cell migration)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|interpro:IPR029071|interpro:IPR035036|interpro:IPR035037|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:Q13322|rcsb pdb:1NRV|rcsb pdb:3HK0|reactome:R-HSA-1433557|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8853659|reactome:R-HSA-9607240|reactome:R-HSA-9648895|ensembl:ENSG00000106070(gene)|ensembl:ENST00000398812(transcript)|ensembl:ENST00000401949(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010467"(gene expression)|refseq:XP_011513606.1|refseq:XP_011513614.1|refseq:XP_011513618.1|refseq:NP_001001549.1|refseq:NP_001001550.1|refseq:NP_001001555.1|refseq:NP_005302.3|refseq:XP_016867534.1|refseq:XP_016867535.1|refseq:XP_016867552.1|refseq:XP_016867553.1|refseq:XP_016867554.1|refseq:XP_016867555.1|refseq:XP_016867556.1|refseq:XP_016867557.1|dip:DIP-31657N|mint:MINT-7908275(identity)|uniprotkb:Q13322(original identifier)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908268(identity)|uniprotkb:Q8IZP0(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:WBLkjS4iCC2gMTzR3izSFXGrBnk9606	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	intact-crc:372F3630A59E82ED|rigid:xm41lbzC9cw83nS5H0XXRRBbal8	false	binding-associated region:493-574(MINT-7908278)|glutathione s tranferase tag:?-?(MINT-7908281)	binding-associated region:412-425(MINT-7908271)|phosphorylated residue:421-421(MINT-7908273)	-	-	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:P10686	uniprotkb:Q8IZP0	intact:EBI-520788	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	psi-mi:plcg1_rat(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym)|uniprotkb:Plcg1(gene name)|psi-mi:Plcg1(display_short)	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8050524|mint:MINT-7908299|imex:IM-15587-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3347|refseq:NP_037319.1|mint:P10686|dip:DIP-2863N|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009306"(protein secretion)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0009629"(response to gravity)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043278"(response to morphine)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901339"(regulation of store-operated calcium channel activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR035724|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|rcsb pdb:1Y0M|rcsb pdb:1YWO|rcsb pdb:1YWP|rcsb pdb:2FJL|rcsb pdb:3GQI|rcsb pdb:4K44|rcsb pdb:4K45|rcsb pdb:5EG3|rcsb pdb:6PBC|reactome:R-RNO-1169408|reactome:R-RNO-1855204|reactome:R-RNO-186763|reactome:R-RNO-202433|reactome:R-RNO-2029485|reactome:R-RNO-212718|reactome:R-RNO-2424491|reactome:R-RNO-2871796|reactome:R-RNO-2871809|reactome:R-RNO-5218921|reactome:R-RNO-5654219|reactome:R-RNO-5654221|reactome:R-RNO-5654227|reactome:R-RNO-5654228|reactome:R-RNO-8853659|reactome:R-RNO-9026527|reactome:R-RNO-9034793|mint:MINT-7908307(identity)|uniprotkb:P10686(original identifier)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908300(identity)|uniprotkb:Q8IZP0(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:yyBTZCUDTiNhcFMPYEWvf2FhOlo10116	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	intact-crc:C782DE4288B3DF1E|rigid:LKeS4//vQ4S1naW9Tne7tPnQ2zs	false	glutathione s tranferase tag:?-?(MINT-7908312)|binding-associated region:550-851(MINT-7908310)	binding-associated region:412-425(MINT-7908303)|phosphorylated residue:421-421(MINT-7908305)	-	-	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q8IZP0	uniprotkb:Q92569	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8050493|mint:MINT-7908283|imex:IM-15587-30	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908284(identity)|uniprotkb:Q8IZP0(original identifier)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	intact-crc:C65170E2C457A7D8|rigid:o7gAtIfPsqiD1g0MCC6HjJtcZec	false	binding-associated region:412-425(MINT-7908287)|phosphorylated residue:421-421(MINT-7908289)	sufficient binding region:65-452|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IZP0	uniprotkb:P42684	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	intact:EBI-1102694|uniprotkb:Q5T0X6|uniprotkb:Q5W0C5|uniprotkb:B7UEF2|uniprotkb:B7UEF3|uniprotkb:B7UEF4|uniprotkb:B7UEF5|uniprotkb:Q6NZY6|uniprotkb:Q7Z301|ensembl:ENSP00000427562|uniprotkb:A0M8X0	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:abl2_human(display_long)|uniprotkb:Abelson tyrosine-protein kinase 2(gene name synonym)|uniprotkb:ABL2(gene name)|psi-mi:ABL2(display_short)|uniprotkb:ABLL(gene name synonym)|uniprotkb:ARG(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 2(gene name synonym)|uniprotkb:Abelson-related gene protein(gene name synonym)|uniprotkb:Tyrosine-protein kinase ARG(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8050550|mint:MINT-7908314|imex:IM-15587-32	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908315(identity)|uniprotkb:Q8IZP0(original identifier)	ensembl:ENSG00000143322(gene)|ensembl:ENST00000502732(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035640"(exploration behavior)|go:"GO:0051015"(actin filament binding)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:0000287"(magnesium ion binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015015(F-actin binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035837|interpro:IPR036028|interpro:IPR036860|mint:P42684|rcsb pdb:2ECD|rcsb pdb:2KK1|rcsb pdb:2XYN|rcsb pdb:3GVU|rcsb pdb:3HMI|rcsb pdb:3ULR|rcsb pdb:4EIH|rcsb pdb:5NP3|rcsb pdb:5NP5|reactome:R-HSA-428890|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9706369|refseq:NP_001129472.1|refseq:NP_001129473.1|refseq:NP_001161708.1|refseq:NP_001161709.1|refseq:NP_001161710.1|refseq:NP_001161711.1|refseq:NP_005149.4|refseq:NP_009298.1|refseq:XP_005245145.1|dip:DIP-91N|mint:MINT-7908322(identity)|uniprotkb:P42684(original identifier)	-	-	crc64:ED93869BC2B14FAA	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	rogid:ct5SG4m0wewDSllBklIOi48BV7Q9606	intact-crc:23875D4C6C3CA681|rigid:Yn4EbclhUnS4UkYuiPMbIazz6+M	false	phosphorylated residue:421-421(MINT-7908320)|binding-associated region:412-425(MINT-7908318)	glutathione s tranferase tag:?-?(MINT-7908328)|binding-associated region:173-263(MINT-7908325)	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)
uniprotkb:Q8IZP0	uniprotkb:P15498	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	intact:EBI-625518|ensembl:ENSP00000472929|uniprotkb:Q15860|uniprotkb:B4DVK9|uniprotkb:M0QXX6	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:vav_human(display_long)|uniprotkb:VAV1(gene name)|psi-mi:VAV1(display_short)|uniprotkb:VAV(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8050595|mint:MINT-7908330|imex:IM-15587-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908331(identity)|uniprotkb:Q8IZP0(original identifier)	go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0072593"(reactive oxygen species metabolic process)|ensembl:ENSG00000141968(gene)|ensembl:ENST00000602142(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030168"(platelet activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031295"(T cell costimulation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0140031"(phosphorylation-dependent protein binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR028530|interpro:IPR035729|interpro:IPR035730|interpro:IPR035879|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P15498|rcsb pdb:2CRH|rcsb pdb:2LCT|rcsb pdb:2MC1|rcsb pdb:2ROR|rcsb pdb:3BJI|rcsb pdb:3KY9|rcsb pdb:6NEW|rcsb pdb:6NF1|rcsb pdb:6NFA|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2219530|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-389359|reactome:R-HSA-416482|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5218920|reactome:R-HSA-6811558|reactome:R-HSA-8980692|reactome:R-HSA-9013149|reactome:R-HSA-9013408|reactome:R-HSA-9027284|reactome:R-HSA-912631|reactome:R-HSA-9664422|reactome:R-HSA-983695|reactome:R-HSA-9013404|refseq:NP_005419.2|refseq:NP_001245136.1|dip:DIP-1061N|mint:MINT-7908338(identity)|uniprotkb:P15498(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	rogid:bQbV6leh4WHm+d0VGVCMuZtR6pU9606	intact-crc:E864F794E5AD2895|rigid:2TlZXY4489bVlWfXny2H+xhHwUc	false	binding-associated region:412-425(MINT-7908334)|phosphorylated residue:421-421(MINT-7908336)	binding-associated region:671-765(MINT-7908341)|glutathione s tranferase tag:?-?(MINT-7908344)	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)
uniprotkb:Q8IZP0	uniprotkb:P62993	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8050623|mint:MINT-7908346|imex:IM-15587-34	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908347(identity)|uniprotkb:Q8IZP0(original identifier)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|mint:MINT-7908354(identity)|uniprotkb:P62993(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:4CDE78B42168D037|rigid:al0Q2/voYF1smJqSwnTi1Uyroks	false	phosphorylated residue:421-421(MINT-7908352)|binding-associated region:412-425(MINT-7908350)	binding-associated region:60-152(MINT-7908357)|glutathione s tranferase tag:?-?(MINT-7908360)	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)
uniprotkb:Q8IZP0	uniprotkb:Q08881	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	intact:EBI-968552|intact:EBI-5773727|intact:EBI-28978067|ensembl:ENSP00000398655|uniprotkb:Q32ML7|uniprotkb:B2R752	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:itk_human(display_long)|uniprotkb:ITK(gene name)|psi-mi:ITK(display_short)|uniprotkb:EMT(gene name synonym)|uniprotkb:LYK(gene name synonym)|uniprotkb:T-cell-specific kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase Lyk(gene name synonym)|uniprotkb:Kinase EMT(gene name synonym)|uniprotkb:Interleukin-2-inducible T-cell kinase(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8050651|mint:MINT-7908362|imex:IM-15587-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908363(identity)|uniprotkb:Q8IZP0(original identifier)	ensembl:ENSG00000113263(gene)|ensembl:ENST00000422843(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001865"(NK T cell differentiation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042110"(T cell activation)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035583|interpro:IPR036028|interpro:IPR036860|interpro:IPR042785|mint:Q08881|rcsb pdb:1SM2|rcsb pdb:1SNU|rcsb pdb:1SNX|rcsb pdb:2E6I|rcsb pdb:2LMJ|rcsb pdb:2YUQ|rcsb pdb:3MIY|rcsb pdb:3MJ1|rcsb pdb:3MJ2|rcsb pdb:3QGW|rcsb pdb:3QGY|rcsb pdb:3T9T|interpro:IPR001849(Pleckstrin-like)|rcsb pdb:3V5J|rcsb pdb:3V5L|rcsb pdb:3V8T|rcsb pdb:3V8W|rcsb pdb:4HCT|rcsb pdb:4HCU|rcsb pdb:4HCV|rcsb pdb:4KIO|rcsb pdb:4L7S|rcsb pdb:4M0Y|rcsb pdb:4M0Z|rcsb pdb:4M12|rcsb pdb:4M13|rcsb pdb:4M14|rcsb pdb:4M15|rcsb pdb:4MF0|rcsb pdb:4MF1|rcsb pdb:4PP9|rcsb pdb:4PPA|rcsb pdb:4PPB|rcsb pdb:4PPC|rcsb pdb:4PQN|rcsb pdb:4QD6|rcsb pdb:4RFM|reactome:R-HSA-202433|reactome:R-HSA-2871809|refseq:NP_005537.3|ensembl:ENSP00000398655|dip:DIP-29974N|mint:MINT-7908370(identity)|uniprotkb:Q08881(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	rogid:DbmEoJ3gxf6xJrG1Qn4mAXASfw89606	intact-crc:3B83923258D80FA2|rigid:pGXZt+TLzvOEan1qF4+GXB9MV7E	false	phosphorylated residue:421-421(MINT-7908368)|binding-associated region:412-425(MINT-7908366)	glutathione s tranferase tag:?-?(MINT-7908376)|binding-associated region:239-338(MINT-7908373)	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)
uniprotkb:Q9ULV8	uniprotkb:Q8IZP0	intact:EBI-2341018|uniprotkb:Q9Y5Z3|uniprotkb:Q8N1E5|uniprotkb:Q9Y5Z2|intact:EBI-28975910|ensembl:ENSP00000494162	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	psi-mi:cblc_human(display_long)|uniprotkb:CBLC(gene name)|psi-mi:CBLC(display_short)|uniprotkb:CBL3(gene name synonym)|uniprotkb:RNF57(gene name synonym)|uniprotkb:SH3-binding protein CBL-C(gene name synonym)|uniprotkb:SH3-binding protein CBL-3(gene name synonym)|uniprotkb:RING finger protein 57(gene name synonym)|uniprotkb:Signal transduction protein CBL-C(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL-C(gene name synonym)	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8050679|mint:MINT-7908378|imex:IM-15587-36	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000341505|ensembl:ENSP00000340250|ensembl:ENSP00000494162|refseq:NP_001124324.1|refseq:NP_036248.3|ensembl:ENSG00000142273(gene)|ensembl:ENST00000647358(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|rcsb pdb:3OP0|rcsb pdb:3VRN|rcsb pdb:3VRO|rcsb pdb:3VRP|rcsb pdb:3VRQ|rcsb pdb:3VRR|mint:MINT-7908386(identity)|uniprotkb:Q9ULV8(original identifier)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908379(identity)|uniprotkb:Q8IZP0(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:syzTzR6RGJzLv2EpDirSrli4ghs9606	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	intact-crc:5AC27230179A68B3|rigid:V1FVPo9HHHhywi1sRhGCuEJ4oXQ	false	binding-associated region:237-311(MINT-7908389)|glutathione s tranferase tag:?-?(MINT-7908392)	phosphorylated residue:213-213(MINT-7908384)|binding-associated region:207-220(MINT-7908382)	-	-	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:P52735	uniprotkb:Q8IZP0	intact:EBI-297549|ensembl:ENSP00000360916|uniprotkb:A2RUM4|uniprotkb:A8MQ12|uniprotkb:Q5SYV3|uniprotkb:Q5SYV4|uniprotkb:Q5SYV5|uniprotkb:Q6N012|uniprotkb:Q6PIJ9|uniprotkb:Q6Q317|uniprotkb:B6ZDF5	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	psi-mi:vav2_human(display_long)|uniprotkb:VAV2(gene name)|psi-mi:VAV2(display_short)	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8050724|mint:MINT-7908394|imex:IM-15587-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000160293(gene)|ensembl:ENST00000371850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030168"(platelet activation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P52735|rcsb pdb:2DLZ|rcsb pdb:2DM1|rcsb pdb:2LNW|rcsb pdb:2LNX|rcsb pdb:4ROJ|reactome:R-HSA-114604|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2424491|reactome:R-HSA-2871796|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|reactome:R-HSA-2871809|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001127870.1|refseq:NP_003362.2|refseq:XP_005272270.1|dip:DIP-33088N|mint:MINT-7908402(identity)|uniprotkb:P52735(original identifier)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908395(identity)|uniprotkb:Q8IZP0(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:usp18HylJidh6mU3Zf0cAzo5ABM9606	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	intact-crc:7DC124940DE7B96E|rigid:kFiOh7yROZop/IBgjHSFKuZ7hS4	false	glutathione s tranferase tag:?-?(MINT-7908408)|binding-associated region:673-767(MINT-7908405)	binding-associated region:207-220(MINT-7908398)|phosphorylated residue:213-213(MINT-7908400)	-	-	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:P46109	uniprotkb:Q8IZP0	intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short)	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8050752|mint:MINT-7908410|imex:IM-15587-38	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631|mint:MINT-7908418(identity)|uniprotkb:P46109(original identifier)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908411(identity)|uniprotkb:Q8IZP0(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	intact-crc:7652BEA593319BCE|rigid:H02/egZVtM4WlGXFUaP6bgjtwjA	false	glutathione s tranferase tag:?-?(MINT-7908424)|binding-associated region:14-102(MINT-7908421)	binding-associated region:207-220(MINT-7908414)|phosphorylated residue:213-213(MINT-7908416)	-	-	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q8IZP0	uniprotkb:Q13191	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	intact:EBI-744027|uniprotkb:Q63Z43|uniprotkb:A8K9S7|uniprotkb:Q13192|uniprotkb:Q13193|uniprotkb:Q3LIC0|uniprotkb:Q8IVC5|uniprotkb:B7WNM4|intact:EBI-28969458|ensembl:ENSP00000377598|intact:EBI-8051403|intact:MINT-7907019	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:cblb_human(display_long)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:RING finger protein 56(gene name synonym)|uniprotkb:CBLB(gene name)|psi-mi:CBLB(display_short)|uniprotkb:RNF56(gene name synonym)|uniprotkb:Nbla00127(orf name)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8050780|mint:MINT-7908426|imex:IM-15587-39	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908427(identity)|uniprotkb:Q8IZP0(original identifier)	refseq:NP_733762.2|refseq:NP_001308717.1|ensembl:ENSP00000377598|ensembl:ENST00000403724|ensembl:ENSP00000384816|ensembl:ENST00000405772|ensembl:ENSP00000384938|refseq:XP_011511559.1|ensembl:ENSG00000114423(gene)|ensembl:ENST00000394030(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018193"(peptidyl-amino acid modification)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0005829"(cytosol)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:Q13191|rcsb pdb:2AK5|rcsb pdb:2BZ8|rcsb pdb:2DO6|rcsb pdb:2J6F|rcsb pdb:2JNH|rcsb pdb:2LDR|rcsb pdb:2OOA|rcsb pdb:2OOB|rcsb pdb:3PFV|rcsb pdb:3VGO|rcsb pdb:3ZNI|reactome:R-HSA-983168|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|dip:DIP-33091N|mint:MINT-7908434(identity)|uniprotkb:Q13191(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	rogid:cJ5eLH0TMyM6OtmS1sM3rhsrsIk9606	intact-crc:8B78467180CB460C|rigid:S+o0JiFC1uWZVih+fJ4yExpVCsw	false	phosphorylated residue:213-213(MINT-7908432)|binding-associated region:207-220(MINT-7908430)	binding-associated region:259-333(MINT-7908437)|glutathione s tranferase tag:?-?(MINT-7908440)	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)
uniprotkb:P42684	uniprotkb:Q8IZP0	intact:EBI-1102694|uniprotkb:Q5T0X6|uniprotkb:Q5W0C5|uniprotkb:B7UEF2|uniprotkb:B7UEF3|uniprotkb:B7UEF4|uniprotkb:B7UEF5|uniprotkb:Q6NZY6|uniprotkb:Q7Z301|ensembl:ENSP00000427562|uniprotkb:A0M8X0	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	psi-mi:abl2_human(display_long)|uniprotkb:Abelson tyrosine-protein kinase 2(gene name synonym)|uniprotkb:ABL2(gene name)|psi-mi:ABL2(display_short)|uniprotkb:ABLL(gene name synonym)|uniprotkb:ARG(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 2(gene name synonym)|uniprotkb:Abelson-related gene protein(gene name synonym)|uniprotkb:Tyrosine-protein kinase ARG(gene name synonym)	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8050826|mint:MINT-7908442|imex:IM-15587-40	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143322(gene)|ensembl:ENST00000502732(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035640"(exploration behavior)|go:"GO:0051015"(actin filament binding)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:0000287"(magnesium ion binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015015(F-actin binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035837|interpro:IPR036028|interpro:IPR036860|mint:P42684|rcsb pdb:2ECD|rcsb pdb:2KK1|rcsb pdb:2XYN|rcsb pdb:3GVU|rcsb pdb:3HMI|rcsb pdb:3ULR|rcsb pdb:4EIH|rcsb pdb:5NP3|rcsb pdb:5NP5|reactome:R-HSA-428890|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9706369|refseq:NP_001129472.1|refseq:NP_001129473.1|refseq:NP_001161708.1|refseq:NP_001161709.1|refseq:NP_001161710.1|refseq:NP_001161711.1|refseq:NP_005149.4|refseq:NP_009298.1|refseq:XP_005245145.1|dip:DIP-91N|mint:MINT-7908450(identity)|uniprotkb:P42684(original identifier)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908443(identity)|uniprotkb:Q8IZP0(original identifier)	-	crc64:ED93869BC2B14FAA	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:ct5SG4m0wewDSllBklIOi48BV7Q9606	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	intact-crc:4B22D9DCF819938A|rigid:Yn4EbclhUnS4UkYuiPMbIazz6+M	false	glutathione s tranferase tag:?-?(MINT-7908456)|binding-associated region:173-263(MINT-7908453)	phosphorylated residue:213-213(MINT-7908448)|binding-associated region:207-220(MINT-7908446)	-	-	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q8BMC3	uniprotkb:Q8IZP0	intact:EBI-8050872|intact:UNK-5507430|ensembl:ENSMUSP00000020564	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	psi-mi:shc2_mouse(display_long)|uniprotkb:Shc2(gene name)|psi-mi:Shc2(display_short)|uniprotkb:Sck(gene name synonym)|uniprotkb:ShcB(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C2(gene name synonym)|uniprotkb:SHC-transforming protein B(gene name synonym)|uniprotkb:Protein Sck(gene name synonym)|uniprotkb:Protein Sli(gene name synonym)	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8050862|mint:MINT-7908458|imex:IM-15587-41	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001019710.1|ensembl:ENSMUSG00000020312(gene)|ensembl:ENSMUST00000020564(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029591|interpro:IPR035676|interpro:IPR036860|reactome:R-MMU-167044|reactome:R-MMU-4420097|reactome:R-MMU-5673001|mint:MINT-7908466(identity)|uniprotkb:Q8BMC3(original identifier)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908459(identity)|uniprotkb:Q8IZP0(original identifier)	-	function:Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons|comment:mint	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:S3J7hj80iko6iiLYyInoN2dgqU410090	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	intact-crc:44BB3948FB19D955|rigid:Pax4vL/oQVItrCk5BTD0RbLPlFs	false	binding-associated region:478-569(MINT-7908469)|glutathione s tranferase tag:?-?(MINT-7908472)	binding-associated region:207-220(MINT-7908462)|phosphorylated residue:213-213(MINT-7908464)	-	-	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q8IZP0	uniprotkb:O00459	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	intact:EBI-346930|uniprotkb:Q5EAT5|uniprotkb:Q9UPH9|intact:EBI-28974273|ensembl:ENSP00000222254	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:p85b_human(display_long)|uniprotkb:PIK3R2(gene name)|psi-mi:PIK3R2(display_short)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8050961|mint:MINT-7908474|imex:IM-15587-42	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908475(identity)|uniprotkb:Q8IZP0(original identifier)	ensembl:ENSP00000222254|refseq:NP_005018.1|dip:DIP-31811N|ensembl:ENSG00000105647(gene)|ensembl:ENST00000222254(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|rcsb pdb:6OX7|rcsb pdb:6U28|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-186763|reactome:R-HSA-198203|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|mint:O00459|rcsb pdb:2KT1|rcsb pdb:2XS6|rcsb pdb:3MTT|rcsb pdb:3O5Z|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-210993|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9013409|mint:MINT-7908482(identity)|uniprotkb:O00459(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	rogid:Ij0WS0eKPwShgFWQc7OEss7AcAU9606	intact-crc:04A66A524ED07664|rigid:32lTeYdwRdEzU1/Vl5Ey7Aajk5o	false	phosphorylated residue:213-213(MINT-7908480)|binding-associated region:207-220(MINT-7908478)	glutathione s tranferase tag:?-?(MINT-7908488)|binding-associated region:330-716(MINT-7908485)	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)
uniprotkb:Q92569	uniprotkb:Q8IZP0	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8051046|mint:MINT-7908490|imex:IM-15587-43	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908491(identity)|uniprotkb:Q8IZP0(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	intact-crc:F30605AB179C6262|rigid:o7gAtIfPsqiD1g0MCC6HjJtcZec	false	sufficient binding region:65-452|glutathione s tranferase tag:?-?	phosphorylated residue:213-213(MINT-7908496)|binding-associated region:207-220(MINT-7908494)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q8IZP0	uniprotkb:P46108	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8051144|mint:MINT-7908506|imex:IM-15587-44	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908507(identity)|uniprotkb:Q8IZP0(original identifier)	ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422|mint:MINT-7908514(identity)|uniprotkb:P46108(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606	intact-crc:A52BEB9CB261D0D4|rigid:X5eJGqTCuO2tXPO6fz8TiFFUNW8	false	phosphorylated residue:213-213(MINT-7908512)|binding-associated region:207-220(MINT-7908510)	glutathione s tranferase tag:?-?(MINT-7908520)|binding-associated region:13-118(MINT-7908517)	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)
uniprotkb:P15498	uniprotkb:Q8IZP0	intact:EBI-625518|ensembl:ENSP00000472929|uniprotkb:Q15860|uniprotkb:B4DVK9|uniprotkb:M0QXX6	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	psi-mi:vav_human(display_long)|uniprotkb:VAV1(gene name)|psi-mi:VAV1(display_short)|uniprotkb:VAV(gene name synonym)	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8051201|mint:MINT-7908522|imex:IM-15587-45	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0072593"(reactive oxygen species metabolic process)|ensembl:ENSG00000141968(gene)|ensembl:ENST00000602142(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030168"(platelet activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031295"(T cell costimulation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0140031"(phosphorylation-dependent protein binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR028530|interpro:IPR035729|interpro:IPR035730|interpro:IPR035879|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P15498|rcsb pdb:2CRH|rcsb pdb:2LCT|rcsb pdb:2MC1|rcsb pdb:2ROR|rcsb pdb:3BJI|rcsb pdb:3KY9|rcsb pdb:6NEW|rcsb pdb:6NF1|rcsb pdb:6NFA|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2219530|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-389359|reactome:R-HSA-416482|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5218920|reactome:R-HSA-6811558|reactome:R-HSA-8980692|reactome:R-HSA-9013149|reactome:R-HSA-9013408|reactome:R-HSA-9027284|reactome:R-HSA-912631|reactome:R-HSA-9664422|reactome:R-HSA-983695|reactome:R-HSA-9013404|refseq:NP_005419.2|refseq:NP_001245136.1|dip:DIP-1061N|mint:MINT-7908530(identity)|uniprotkb:P15498(original identifier)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908523(identity)|uniprotkb:Q8IZP0(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:bQbV6leh4WHm+d0VGVCMuZtR6pU9606	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	intact-crc:80C1730471881D9E|rigid:2TlZXY4489bVlWfXny2H+xhHwUc	false	binding-associated region:671-765(MINT-7908533)|glutathione s tranferase tag:?-?(MINT-7908536)	phosphorylated residue:213-213(MINT-7908528)|binding-associated region:207-220(MINT-7908526)	-	-	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q8IZP0	uniprotkb:O14512	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	intact:EBI-1539606|uniprotkb:A2VCU2|uniprotkb:Q0IJ63|ensembl:ENSP00000480736|ensembl:ENSP00000499750	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:socs7_human(display_long)|uniprotkb:SOCS7(gene name)|psi-mi:SOCS7(display_short)|uniprotkb:NAP4(gene name synonym)|uniprotkb:SOCS6(gene name synonym)|uniprotkb:Nck, Ash and phospholipase C gamma-binding protein(gene name synonym)|uniprotkb:Nck-associated protein 4(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8051229|mint:MINT-7908538|imex:IM-15587-46	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908539(identity)|uniprotkb:Q8IZP0(original identifier)	refseq:NP_055413.1|ensembl:ENSG00000274211(gene)|ensembl:ENSG00000274229(gene)|ensembl:ENST00000615473(transcript)|ensembl:ENST00000665913(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR028423|interpro:IPR035866|interpro:IPR036036|interpro:IPR036860|interpro:IPR037346|mint:MINT-7908546(identity)|uniprotkb:O14512(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	rogid:MbBKOLby106g9tDOvy4FhIG6lgY9606	intact-crc:9CDCC9969D5157DC|rigid:7ZT/qlwY931rwUhR47Ppt2Hjuv8	false	phosphorylated residue:213-213(MINT-7908544)|binding-associated region:207-220(MINT-7908542)	binding-associated region:400-509(MINT-7908549)|glutathione s tranferase tag:?-?(MINT-7908552)	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)
uniprotkb:P00520	uniprotkb:Q8IZP0	intact:EBI-914519|uniprotkb:P97896|uniprotkb:Q61252|uniprotkb:Q61253|uniprotkb:Q61254|uniprotkb:Q61255|uniprotkb:Q61256|uniprotkb:Q61257|uniprotkb:Q61258|uniprotkb:Q61259|uniprotkb:Q61260|uniprotkb:Q61261|uniprotkb:Q6PCM5|uniprotkb:Q8C1X4|ensembl:ENSMUSP00000028190	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	psi-mi:abl1_mouse(display_long)|uniprotkb:Abl1(gene name)|psi-mi:Abl1(display_short)|uniprotkb:Abl(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 1(gene name synonym)|uniprotkb:Proto-oncogene c-Abl(gene name synonym)|uniprotkb:p150(gene name synonym)|uniprotkb:Abelson tyrosine-protein kinase 1(gene name synonym)	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8051274|mint:MINT-7908554|imex:IM-15587-47	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269974.1|refseq:NP_001269975.1|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016301"(kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030035"(microspike assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0038191"(neuropilin binding)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|ensembl:ENSMUSG00000026842(gene)|ensembl:ENSMUST00000028190(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002333"(transitional one stage B cell differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|refseq:NP_001106174.1|refseq:NP_033724.2|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048668"(collateral sprouting)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071103"(DNA conformation change)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072359"(circulatory system development)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090135"(actin filament branching)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900275"(negative regulation of phospholipase C activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903053"(regulation of extracellular matrix organization)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015015(F-actin binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR033221|interpro:IPR035837|interpro:IPR036028|interpro:IPR036860|mint:P00520|rcsb pdb:1ABO|rcsb pdb:1ABQ|rcsb pdb:1FPU|rcsb pdb:1IEP|rcsb pdb:1M52|rcsb pdb:1OPJ|rcsb pdb:1OPK|rcsb pdb:2HZN|rcsb pdb:2QOH|rcsb pdb:2Z60|rcsb pdb:3DK3|rcsb pdb:3DK6|rcsb pdb:3DK7|rcsb pdb:3IK3|rcsb pdb:3K5V|rcsb pdb:3KF4|rcsb pdb:3KFA|rcsb pdb:3MS9|rcsb pdb:3MSS|rcsb pdb:3OXZ|rcsb pdb:3OY3|rcsb pdb:5IH2|rcsb pdb:6HD4|rcsb pdb:6HD6|reactome:R-MMU-2029482|reactome:R-MMU-428890|reactome:R-MMU-525793|reactome:R-MMU-5663213|reactome:R-MMU-5685938|reactome:R-MMU-5693565|reactome:R-MMU-69231|reactome:R-MMU-8939236|mint:MINT-7908562(identity)|uniprotkb:P00520(original identifier)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908555(identity)|uniprotkb:Q8IZP0(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:Ua709ju5WT1NhOz3n4xzlEBD0Cw10090	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	intact-crc:D9C2AD3412B13768|rigid:NCJOZH0WK7/pqGRnJLBUPp8iJ+s	false	glutathione s tranferase tag:?-?(MINT-7908568)|binding-associated region:121-217(MINT-7908565)	phosphorylated residue:213-213(MINT-7908560)|binding-associated region:207-220(MINT-7908558)	-	-	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q8IZP0	uniprotkb:P35235	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	intact:EBI-397236|uniprotkb:Q3TQ84|uniprotkb:Q64509|uniprotkb:Q6PCL5|ensembl:ENSMUSP00000098333	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:ptn11_mouse(display_long)|uniprotkb:Ptpn11(gene name)|psi-mi:Ptpn11(display_short)|uniprotkb:Protein-tyrosine phosphatase SYP(gene name synonym)|uniprotkb:SH-PTP2(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8051302|mint:MINT-7908570|imex:IM-15587-48	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908571(identity)|uniprotkb:Q8IZP0(original identifier)	refseq:NP_001103462.1|refseq:NP_035332.1|go:"GO:0048609"(multicellular organismal reproductive process)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0048806"(genitalia development)|go:"GO:0048839"(inner ear development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051463"(negative regulation of cortisol secretion)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060325"(face morphogenesis)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0061582"(intestinal epithelial cell migration)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P35235|rcsb pdb:1AYA|rcsb pdb:1AYB|rcsb pdb:1AYC|rcsb pdb:1AYD|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|reactome:R-MMU-1059683|reactome:R-MMU-109704|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|reactome:R-MMU-110056|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|reactome:R-MMU-112411|reactome:R-MMU-114604|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|reactome:R-MMU-1257604|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-210990|reactome:R-MMU-210993|reactome:R-MMU-388841|reactome:R-MMU-389513|reactome:R-MMU-389948|reactome:R-MMU-432142|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-8854691|reactome:R-MMU-8865999|reactome:R-MMU-8934593|reactome:R-MMU-909733|reactome:R-MMU-912694|reactome:R-MMU-936964|reactome:R-MMU-9674555|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654700|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-6811558|reactome:R-MMU-8853659|ensembl:ENSMUSG00000043733(gene)|ensembl:ENSMUST00000100770(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030220"(platelet formation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032528"(microvillus organization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035265"(organ growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|dip:DIP-29669N|mint:MINT-7908578(identity)|uniprotkb:P35235(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2020/01/07	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	rogid:KL26Wt9vwG525fZ5SfvLc71Wsng10090	intact-crc:1A58C0D3F62FDB8F|rigid:dsWerPuoMjxKqD9jGwgMXRJGi58	false	binding-associated region:207-220(MINT-7908574)|phosphorylated residue:213-213(MINT-7908576)	binding-associated region:6-216(MINT-7908581)|glutathione s tranferase tag:?-?(MINT-7908584)	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)
uniprotkb:Q8IZP0	uniprotkb:P20936	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8051330|mint:MINT-7908586|imex:IM-15587-49	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908587(identity)|uniprotkb:Q8IZP0(original identifier)	refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N|mint:MINT-7908594(identity)|uniprotkb:P20936(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606	intact-crc:BCA19268B4957EDB|rigid:V5ZkhqD2hS3wyFOOz4Ezo2VNX3E	false	phosphorylated residue:213-213(MINT-7908592)|binding-associated region:207-220(MINT-7908590)	glutathione s tranferase tag:?-?(MINT-7908600)|binding-associated region:181-441(MINT-7908597)	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)
uniprotkb:Q8IZP0	uniprotkb:O15357	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	intact:EBI-1384248|uniprotkb:Q13577|uniprotkb:Q13578|uniprotkb:B2RTX5|ensembl:ENSP00000298229	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:ship2_human(display_long)|uniprotkb:INPPL1(gene name)|psi-mi:INPPL1(display_short)|uniprotkb:SHIP2(gene name synonym)|uniprotkb:Inositol polyphosphate phosphatase-like protein 1(gene name synonym)|uniprotkb:Protein 51C(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 2(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8051375|mint:MINT-7908602|imex:IM-15587-50	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908603(identity)|uniprotkb:Q8IZP0(original identifier)	ensembl:ENSP00000298229|ensembl:ENST00000538751|ensembl:ENSP00000444619|refseq:NP_001558.3|refseq:XP_011543301.1|dip:DIP-39733N|ensembl:ENSG00000165458(gene)|ensembl:ENST00000298229(transcript)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002376"(immune system process)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0032868"(response to insulin)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0097178"(ruffle assembly)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036691|interpro:IPR036860|mint:O15357|rcsb pdb:2K4P|rcsb pdb:2KSO|rcsb pdb:2MK2|rcsb pdb:3NR8|rcsb pdb:4A9C|rcsb pdb:5OKM|rcsb pdb:5OKN|rcsb pdb:5OKO|rcsb pdb:5OKP|rcsb pdb:6SQU|rcsb pdb:6SRR|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-912526|mint:MINT-7908610(identity)|uniprotkb:O15357(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2014/10/16	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	rogid:FmRJZVZS8n00OVhTEfEo5gxIvG49606	intact-crc:3BCF712914BD953F|rigid:PzeI21f5cpMerBXkYW3V2HmOTXs	false	phosphorylated residue:213-213(MINT-7908608)|binding-associated region:207-220(MINT-7908606)	binding-associated region:21-117(MINT-7908613)|glutathione s tranferase tag:?-?(MINT-7908616)	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)
uniprotkb:Q13191	uniprotkb:Q8IZP0	intact:EBI-744027|uniprotkb:Q63Z43|uniprotkb:A8K9S7|uniprotkb:Q13192|uniprotkb:Q13193|uniprotkb:Q3LIC0|uniprotkb:Q8IVC5|uniprotkb:B7WNM4|intact:EBI-28969458|ensembl:ENSP00000377598|intact:EBI-8051403|intact:MINT-7907019	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	psi-mi:cblb_human(display_long)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:RING finger protein 56(gene name synonym)|uniprotkb:CBLB(gene name)|psi-mi:CBLB(display_short)|uniprotkb:RNF56(gene name synonym)|uniprotkb:Nbla00127(orf name)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym)	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:"MI:0008"(array technology)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8051437|mint:MINT-7908618|imex:IM-15587-51	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_733762.2|refseq:NP_001308717.1|ensembl:ENSP00000377598|ensembl:ENST00000403724|ensembl:ENSP00000384816|ensembl:ENST00000405772|ensembl:ENSP00000384938|refseq:XP_011511559.1|ensembl:ENSG00000114423(gene)|ensembl:ENST00000394030(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018193"(peptidyl-amino acid modification)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0005829"(cytosol)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:Q13191|rcsb pdb:2AK5|rcsb pdb:2BZ8|rcsb pdb:2DO6|rcsb pdb:2J6F|rcsb pdb:2JNH|rcsb pdb:2LDR|rcsb pdb:2OOA|rcsb pdb:2OOB|rcsb pdb:3PFV|rcsb pdb:3VGO|rcsb pdb:3ZNI|reactome:R-HSA-983168|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|dip:DIP-33091N|mint:MINT-7908626(identity)|uniprotkb:B5MC15(original identifier)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908619(identity)|uniprotkb:Q8IZP0(original identifier)	-	-	-	comment:homomint|figure legend:sf1|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2019/10/18	rogid:cJ5eLH0TMyM6OtmS1sM3rhsrsIk9606	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	intact-crc:FA660B204A2A8F76|rigid:S+o0JiFC1uWZVih+fJ4yExpVCsw	false	binding-associated region:?-?(MINT-7908629)|glutathione s tranferase tag:?-?(MINT-7908631)	binding-associated region:207-220(MINT-7908622)|phosphorylated residue:213-213(MINT-7908624)	-	-	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:P26450	uniprotkb:Q8IZP0	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8049654|mint:MINT-7907981|imex:IM-15587-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270|mint:MINT-7907982(identity)|uniprotkb:P26450(original identifier)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7907990(identity)|uniprotkb:Q8IZP0(original identifier)	-	-	-	figure legend:f3a|comment:homomint|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-lncap)|taxid:9606(Human caucasian prostate carcinoma)	-	2010/06/18	2014/10/16	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	intact-crc:6DAE982768BF97D8|rigid:2VDr+/aYR9Iy6qO+P+m+vLxmMTI	false	green fluorescent protein tag:?-?(MINT-7907988)|binding-associated region:333-428(MINT-7907985)	ha tag:?-?(MINT-7907993)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IZP0	uniprotkb:P26450	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8049709|mint:MINT-7907995|imex:IM-15587-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908004(identity)|uniprotkb:Q8IZP0(original identifier)	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270|mint:MINT-7907996(identity)|uniprotkb:P26450(original identifier)	-	-	-	figure legend:f3a|comment:homomint|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-lncap)|taxid:9606(Human caucasian prostate carcinoma)	-	2010/06/18	2014/10/16	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	intact-crc:25CA2C704AC2DBC4|rigid:2VDr+/aYR9Iy6qO+P+m+vLxmMTI	false	ha tag:?-?(MINT-7908007)	binding-associated region:624-718(MINT-7907999)|green fluorescent protein tag:?-?(MINT-7908002)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:P26450	uniprotkb:Q8IZP0	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	intact:EBI-375446|uniprotkb:O15147|uniprotkb:O76049|uniprotkb:O95060|uniprotkb:Q5W070|uniprotkb:Q5W072|uniprotkb:Q8TB63|uniprotkb:Q96S81|uniprotkb:Q9NXZ9|uniprotkb:Q9NYB8|intact:EBI-28968938|ensembl:ENSP00000365312|uniprotkb:A9Z1Y6|uniprotkb:Q5T2R3|uniprotkb:Q5T2R4|uniprotkb:Q5T2R6|uniprotkb:Q5T2R7|uniprotkb:B4DQ58|uniprotkb:Q5T2R9|uniprotkb:B3KX62|uniprotkb:H7BXI6	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:abi1_human(display_long)|uniprotkb:ABI1(gene name)|psi-mi:ABI1(display_short)|uniprotkb:SSH3BP1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Nap1-binding protein(gene name synonym)|uniprotkb:Abl-binding protein 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Dubielecka et al. (2010)	pubmed:20598684|imex:IM-15587|mint:MINT-7907811|doi:10.1016/j.febslet.2010.06.029	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8049785|mint:MINT-7908011|imex:IM-15587-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270|mint:MINT-7908012(identity)|uniprotkb:P26450(original identifier)	refseq:NP_001012768.1|refseq:NP_001012769.1|refseq:NP_001012770.1|refseq:NP_001171590.1|refseq:NP_001171591.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045296"(cadherin binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072673"(lamellipodium morphogenesis)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8IZP0|ensembl:ENST00000376142(transcript)|go:"GO:0001756"(somitogenesis)|ensembl:ENSG00000136754(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|refseq:NP_001171592.1|refseq:NP_001171593.1|refseq:NP_001171594.1|refseq:NP_001171595.1|refseq:NP_005461.2|ensembl:ENST00000346832|ensembl:ENSP00000279599|ensembl:ENST00000359188|ensembl:ENSP00000352114|ensembl:ENST00000376137|ensembl:ENSP00000365307|ensembl:ENST00000376138|ensembl:ENSP00000365308|ensembl:ENST00000376139|ensembl:ENSP00000365309|ensembl:ENST00000376140|ensembl:ENSP00000365310|ensembl:ENSP00000365312|ensembl:ENST00000376166|ensembl:ENSP00000365336|ensembl:ENST00000376170|ensembl:ENSP00000365340|ensembl:ENST00000490841|ensembl:ENSP00000440101|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001171596.1|refseq:NP_001171587.1|dip:DIP-31118N|mint:MINT-7908017(identity)|uniprotkb:Q8IZP0(original identifier)	-	-	-	figure legend:f3c|comment:homomint|comment:domino|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2010/06/18	2014/10/16	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	rogid:mO2D5R8ZlYmsh+fXdJpaHZOssfs9606	intact-crc:BA40B4B4A2F52610|rigid:2VDr+/aYR9Iy6qO+P+m+vLxmMTI	false	glutathione s tranferase tag:?-?(MINT-7908015)	binding-associated region:390-508(MINT-7908020)|his tag:?-?(MINT-7908023)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0705"(anti tag western blot)