#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q03164-PRO_0000390950 uniprotkb:Q92794 intact:EBI-2638616 intact:EBI-948013|intact:EBI-1048839|uniprotkb:Q76L81|ensembl:ENSP00000265713|ensembl:ENSP00000380136 psi-mi:q03164-pro_0000390950(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym) psi-mi:kat6a_human(display_long)|uniprotkb:KAT6A(gene name)|psi-mi:KAT6A(display_short)|uniprotkb:MOZ(gene name synonym)|uniprotkb:RUNXBP2(gene name synonym)|uniprotkb:ZNF220(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3(gene name synonym)|uniprotkb:Runt-related transcription factor-binding protein 2(gene name synonym)|uniprotkb:Monocytic leukemia zinc finger protein(gene name synonym)|uniprotkb:Zinc finger protein 220(gene name synonym)|uniprotkb:MYST3(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Paggetti et al. (2010) imex:IM-15115|pubmed:20581860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1262"(I2D) intact:EBI-2927085|imex:IM-15115-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-591370(chain-parent) refseq:NP_006757.2|ensembl:ENSP00000265713|ensembl:ENSP00000380136|refseq:XP_016869352.1|refseq:XP_016869353.1|ensembl:ENSG00000083168(gene)|ensembl:ENST00000265713(transcript)|ensembl:ENST00000396930(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006323"(DNA packaging)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070776"(MOZ/MORF histone acetyltransferase complex)|go:"GO:0090398"(cellular senescence)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR005818(Histone H1/H5)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR019787|interpro:IPR031280|interpro:IPR036388|interpro:IPR036390|interpro:IPR040706|mint:Q92794|rcsb pdb:1M36|rcsb pdb:2LN0|rcsb pdb:2OZU|rcsb pdb:2RC4|rcsb pdb:3V43|rcsb pdb:4LJN|rcsb pdb:4LK9|rcsb pdb:4LKA|rcsb pdb:4LLB|rcsb pdb:5B75|rcsb pdb:5B76|rcsb pdb:5B77|rcsb pdb:5B78|rcsb pdb:6LSB|reactome:R-HSA-3214847|reactome:R-HSA-6804758 go:"GO:0005634"(nucleus) comment:Amino acids 2719 � 3969. An C-terminal cleavage product of 180 kDa, identifier Q03164-PRO_0000390950. Short name is p180.|chain-seq-start:2719|chain-seq-end:3969 - figure legend:Fig. 1a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2010/09/14 2014/10/16 rogid:eI+u9uVhnzVAB4k4fks1BqNFDw09606 rogid:jPgi03a1G13Lv1IjZOz9vz1FvcY9606 intact-crc:268D4B1385D91DD0|rigid:VNKZoovB0m8iJvRTZVuOMzCScjk false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q92794 uniprotkb:Q03164-PRO_0000390950 intact:EBI-948013|intact:EBI-1048839|uniprotkb:Q76L81|ensembl:ENSP00000265713|ensembl:ENSP00000380136 intact:EBI-2638616 psi-mi:kat6a_human(display_long)|uniprotkb:KAT6A(gene name)|psi-mi:KAT6A(display_short)|uniprotkb:MOZ(gene name synonym)|uniprotkb:RUNXBP2(gene name synonym)|uniprotkb:ZNF220(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3(gene name synonym)|uniprotkb:Runt-related transcription factor-binding protein 2(gene name synonym)|uniprotkb:Monocytic leukemia zinc finger protein(gene name synonym)|uniprotkb:Zinc finger protein 220(gene name synonym)|uniprotkb:MYST3(gene name synonym) psi-mi:q03164-pro_0000390950(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Paggetti et al. (2010) imex:IM-15115|pubmed:20581860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1262"(I2D) intact:EBI-2927105|imex:IM-15115-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006757.2|ensembl:ENSP00000265713|ensembl:ENSP00000380136|refseq:XP_016869352.1|refseq:XP_016869353.1|ensembl:ENSG00000083168(gene)|ensembl:ENST00000265713(transcript)|ensembl:ENST00000396930(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006323"(DNA packaging)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070776"(MOZ/MORF histone acetyltransferase complex)|go:"GO:0090398"(cellular senescence)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR005818(Histone H1/H5)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR019787|interpro:IPR031280|interpro:IPR036388|interpro:IPR036390|interpro:IPR040706|mint:Q92794|rcsb pdb:1M36|rcsb pdb:2LN0|rcsb pdb:2OZU|rcsb pdb:2RC4|rcsb pdb:3V43|rcsb pdb:4LJN|rcsb pdb:4LK9|rcsb pdb:4LKA|rcsb pdb:4LLB|rcsb pdb:5B75|rcsb pdb:5B76|rcsb pdb:5B77|rcsb pdb:5B78|rcsb pdb:6LSB|reactome:R-HSA-3214847|reactome:R-HSA-6804758 intact:EBI-591370(chain-parent) go:"GO:0005634"(nucleus) - comment:Amino acids 2719 � 3969. An C-terminal cleavage product of 180 kDa, identifier Q03164-PRO_0000390950. Short name is p180.|chain-seq-start:2719|chain-seq-end:3969 figure legend:Fig. 1b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.) - 2010/09/14 2014/10/16 rogid:jPgi03a1G13Lv1IjZOz9vz1FvcY9606 rogid:eI+u9uVhnzVAB4k4fks1BqNFDw09606 intact-crc:2A6887D5A09A4865|rigid:VNKZoovB0m8iJvRTZVuOMzCScjk false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q92794 uniprotkb:P61964 intact:EBI-948013|intact:EBI-1048839|uniprotkb:Q76L81|ensembl:ENSP00000265713|ensembl:ENSP00000380136 intact:EBI-540834|uniprotkb:Q91VA5|uniprotkb:Q9NWX7|uniprotkb:Q9UGP9|intact:EBI-28992503|ensembl:ENSP00000351446|intact:EBI-5774097 psi-mi:kat6a_human(display_long)|uniprotkb:KAT6A(gene name)|psi-mi:KAT6A(display_short)|uniprotkb:MOZ(gene name synonym)|uniprotkb:RUNXBP2(gene name synonym)|uniprotkb:ZNF220(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3(gene name synonym)|uniprotkb:Runt-related transcription factor-binding protein 2(gene name synonym)|uniprotkb:Monocytic leukemia zinc finger protein(gene name synonym)|uniprotkb:Zinc finger protein 220(gene name synonym)|uniprotkb:MYST3(gene name synonym) psi-mi:wdr5_human(display_long)|uniprotkb:BMP2-induced 3-kb gene protein(gene name synonym)|uniprotkb:WDR5(gene name)|psi-mi:WDR5(display_short)|uniprotkb:BIG3(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Paggetti et al. (2010) imex:IM-15115|pubmed:20581860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1262"(I2D) intact:EBI-2927266|imex:IM-15115-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006757.2|ensembl:ENSP00000265713|ensembl:ENSP00000380136|refseq:XP_016869352.1|refseq:XP_016869353.1|ensembl:ENSG00000083168(gene)|ensembl:ENST00000265713(transcript)|ensembl:ENST00000396930(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006323"(DNA packaging)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070776"(MOZ/MORF histone acetyltransferase complex)|go:"GO:0090398"(cellular senescence)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR005818(Histone H1/H5)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR019787|interpro:IPR031280|interpro:IPR036388|interpro:IPR036390|interpro:IPR040706|mint:Q92794|rcsb pdb:1M36|rcsb pdb:2LN0|rcsb pdb:2OZU|rcsb pdb:2RC4|rcsb pdb:3V43|rcsb pdb:4LJN|rcsb pdb:4LK9|rcsb pdb:4LKA|rcsb pdb:4LLB|rcsb pdb:5B75|rcsb pdb:5B76|rcsb pdb:5B77|rcsb pdb:5B78|rcsb pdb:6LSB|reactome:R-HSA-3214847|reactome:R-HSA-6804758 refseq:NP_060058.1|refseq:NP_438172.1|rcsb pdb:4GMB|rcsb pdb:4IA9|rcsb pdb:4O45|rcsb pdb:4QL1|rcsb pdb:4Y7R|rcsb pdb:5EAL|rcsb pdb:5EAM|rcsb pdb:5EAP|rcsb pdb:5EAR|rcsb pdb:5M23|rcsb pdb:5M25|rcsb pdb:5SXM|rcsb pdb:5VFC|rcsb pdb:6BYN|rcsb pdb:6D9X|rcsb pdb:6DAI|rcsb pdb:6DAK|rcsb pdb:6DAR|rcsb pdb:6DAS|rcsb pdb:6DY7|rcsb pdb:6DYA|rcsb pdb:6E1Y|rcsb pdb:6E1Z|rcsb pdb:6E22|rcsb pdb:6E23|rcsb pdb:6IAM|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6OFZ|rcsb pdb:6OI0|rcsb pdb:6OI1|rcsb pdb:6OI2|rcsb pdb:6OI3|rcsb pdb:6PG3|rcsb pdb:6PG4|rcsb pdb:6PG5|rcsb pdb:6PG6|rcsb pdb:6PG7|rcsb pdb:6PG8|rcsb pdb:6PG9|rcsb pdb:6PGA|rcsb pdb:6PGB|rcsb pdb:6PGC|rcsb pdb:6PGD|rcsb pdb:6PGE|rcsb pdb:6PGF|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U5M|rcsb pdb:6U5Y|rcsb pdb:6U6W|rcsb pdb:6U80|rcsb pdb:6U8B|rcsb pdb:6U8L|rcsb pdb:6U8O|rcsb pdb:6UCS|rcsb pdb:6UFX|rcsb pdb:6UHY|rcsb pdb:6UHZ|rcsb pdb:6UIF|rcsb pdb:6UIK|rcsb pdb:6UJ4|rcsb pdb:6UJH|rcsb pdb:6UJJ|rcsb pdb:6UJL|rcsb pdb:6UOZ|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WJQ|rcsb pdb:7DNO|reactome:R-HSA-3214841|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5617472|reactome:R-HSA-8936459|reactome:R-HSA-8951664|ensembl:ENSG00000196363(gene)|ensembl:ENST00000358625(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0001501"(skeletal system development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P61964|rcsb pdb:2CNX|rcsb pdb:2CO0|rcsb pdb:2G99|rcsb pdb:2G9A|rcsb pdb:2GNQ|rcsb pdb:2H13|rcsb pdb:2H14|rcsb pdb:2H68|rcsb pdb:2H6K|rcsb pdb:2H6N|rcsb pdb:2H6Q|rcsb pdb:2H9L|rcsb pdb:2H9M|rcsb pdb:2H9N|rcsb pdb:2H9P|rcsb pdb:2O9K|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3MXX|rcsb pdb:3N0D|rcsb pdb:3N0E|rcsb pdb:3P4F|rcsb pdb:3PSL|rcsb pdb:3SMR|rcsb pdb:3UR4|rcsb pdb:3UVK|rcsb pdb:3UVL|rcsb pdb:3UVM|rcsb pdb:3UVN|rcsb pdb:3UVO|rcsb pdb:4A7J|rcsb pdb:4CY1|rcsb pdb:4CY2|rcsb pdb:4ERQ|rcsb pdb:4ERY|rcsb pdb:4ERZ|rcsb pdb:4ES0|rcsb pdb:4ESG|rcsb pdb:4EWR|rcsb pdb:4GM3|rcsb pdb:4GM8|rcsb pdb:4GM9|ensembl:ENSP00000351446|refseq:XP_005272220.1|dip:DIP-29223N go:"GO:0005634"(nucleus) - - figure legend:Fig. 4a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.) - 2010/09/14 2014/10/16 rogid:jPgi03a1G13Lv1IjZOz9vz1FvcY9606 rogid:MNq7yCtkHPFRGiq1fP5TAwcGUAU9606 intact-crc:69A43E2BB0264B2B|rigid:76v+57OxmlWBBWiuBJO4z4nVVRw false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q03164-PRO_0000390950 uniprotkb:Q92794 intact:EBI-2638616 intact:EBI-948013|intact:EBI-1048839|uniprotkb:Q76L81|ensembl:ENSP00000265713|ensembl:ENSP00000380136 psi-mi:q03164-pro_0000390950(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym) psi-mi:kat6a_human(display_long)|uniprotkb:KAT6A(gene name)|psi-mi:KAT6A(display_short)|uniprotkb:MOZ(gene name synonym)|uniprotkb:RUNXBP2(gene name synonym)|uniprotkb:ZNF220(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3(gene name synonym)|uniprotkb:Runt-related transcription factor-binding protein 2(gene name synonym)|uniprotkb:Monocytic leukemia zinc finger protein(gene name synonym)|uniprotkb:Zinc finger protein 220(gene name synonym)|uniprotkb:MYST3(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Paggetti et al. (2010) imex:IM-15115|pubmed:20581860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1262"(I2D) intact:EBI-2927109|imex:IM-15115-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-591370(chain-parent) refseq:NP_006757.2|ensembl:ENSP00000265713|ensembl:ENSP00000380136|refseq:XP_016869352.1|refseq:XP_016869353.1|ensembl:ENSG00000083168(gene)|ensembl:ENST00000265713(transcript)|ensembl:ENST00000396930(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006323"(DNA packaging)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070776"(MOZ/MORF histone acetyltransferase complex)|go:"GO:0090398"(cellular senescence)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR005818(Histone H1/H5)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR019787|interpro:IPR031280|interpro:IPR036388|interpro:IPR036390|interpro:IPR040706|mint:Q92794|rcsb pdb:1M36|rcsb pdb:2LN0|rcsb pdb:2OZU|rcsb pdb:2RC4|rcsb pdb:3V43|rcsb pdb:4LJN|rcsb pdb:4LK9|rcsb pdb:4LKA|rcsb pdb:4LLB|rcsb pdb:5B75|rcsb pdb:5B76|rcsb pdb:5B77|rcsb pdb:5B78|rcsb pdb:6LSB|reactome:R-HSA-3214847|reactome:R-HSA-6804758 go:"GO:0005634"(nucleus) comment:Amino acids 2719 � 3969. An C-terminal cleavage product of 180 kDa, identifier Q03164-PRO_0000390950. Short name is p180.|chain-seq-start:2719|chain-seq-end:3969 - figure legend:Fig. 1c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-pbmc)|taxid:9606(Human Peripheral Blood Mononuclear cell) - 2010/09/14 2014/10/16 rogid:eI+u9uVhnzVAB4k4fks1BqNFDw09606 rogid:jPgi03a1G13Lv1IjZOz9vz1FvcY9606 intact-crc:DD37D2CE1DFD9581|rigid:VNKZoovB0m8iJvRTZVuOMzCScjk false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q03164-PRO_0000390950 uniprotkb:Q92794 intact:EBI-2638616 intact:EBI-948013|intact:EBI-1048839|uniprotkb:Q76L81|ensembl:ENSP00000265713|ensembl:ENSP00000380136 psi-mi:q03164-pro_0000390950(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym) psi-mi:kat6a_human(display_long)|uniprotkb:KAT6A(gene name)|psi-mi:KAT6A(display_short)|uniprotkb:MOZ(gene name synonym)|uniprotkb:RUNXBP2(gene name synonym)|uniprotkb:ZNF220(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3(gene name synonym)|uniprotkb:Runt-related transcription factor-binding protein 2(gene name synonym)|uniprotkb:Monocytic leukemia zinc finger protein(gene name synonym)|uniprotkb:Zinc finger protein 220(gene name synonym)|uniprotkb:MYST3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Paggetti et al. (2010) imex:IM-15115|pubmed:20581860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1262"(I2D) intact:EBI-2927127|imex:IM-15115-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-591370(chain-parent) refseq:NP_006757.2|ensembl:ENSP00000265713|ensembl:ENSP00000380136|refseq:XP_016869352.1|refseq:XP_016869353.1|ensembl:ENSG00000083168(gene)|ensembl:ENST00000265713(transcript)|ensembl:ENST00000396930(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006323"(DNA packaging)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070776"(MOZ/MORF histone acetyltransferase complex)|go:"GO:0090398"(cellular senescence)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR005818(Histone H1/H5)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR019787|interpro:IPR031280|interpro:IPR036388|interpro:IPR036390|interpro:IPR040706|mint:Q92794|rcsb pdb:1M36|rcsb pdb:2LN0|rcsb pdb:2OZU|rcsb pdb:2RC4|rcsb pdb:3V43|rcsb pdb:4LJN|rcsb pdb:4LK9|rcsb pdb:4LKA|rcsb pdb:4LLB|rcsb pdb:5B75|rcsb pdb:5B76|rcsb pdb:5B77|rcsb pdb:5B78|rcsb pdb:6LSB|reactome:R-HSA-3214847|reactome:R-HSA-6804758 psi-mi:"MI:0469"(intact) comment:Amino acids 2719 � 3969. An C-terminal cleavage product of 180 kDa, identifier Q03164-PRO_0000390950. Short name is p180.|chain-seq-start:2719|chain-seq-end:3969 - figure legend:Fig. 1d|antibodies:Monoclonal antibody used was generated against residues 856-870 of MOZ|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2010/09/14 2014/10/16 rogid:eI+u9uVhnzVAB4k4fks1BqNFDw09606 rogid:jPgi03a1G13Lv1IjZOz9vz1FvcY9606 intact-crc:D2D433E7E8D5758E|rigid:VNKZoovB0m8iJvRTZVuOMzCScjk false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q03164-PRO_0000390950 uniprotkb:Q92794 intact:EBI-2638616 intact:EBI-948013|intact:EBI-1048839|uniprotkb:Q76L81|ensembl:ENSP00000265713|ensembl:ENSP00000380136 psi-mi:q03164-pro_0000390950(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym) psi-mi:kat6a_human(display_long)|uniprotkb:KAT6A(gene name)|psi-mi:KAT6A(display_short)|uniprotkb:MOZ(gene name synonym)|uniprotkb:RUNXBP2(gene name synonym)|uniprotkb:ZNF220(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3(gene name synonym)|uniprotkb:Runt-related transcription factor-binding protein 2(gene name synonym)|uniprotkb:Monocytic leukemia zinc finger protein(gene name synonym)|uniprotkb:Zinc finger protein 220(gene name synonym)|uniprotkb:MYST3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Paggetti et al. (2010) imex:IM-15115|pubmed:20581860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1262"(I2D) intact:EBI-2927144|imex:IM-15115-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-591370(chain-parent) refseq:NP_006757.2|ensembl:ENSP00000265713|ensembl:ENSP00000380136|refseq:XP_016869352.1|refseq:XP_016869353.1|ensembl:ENSG00000083168(gene)|ensembl:ENST00000265713(transcript)|ensembl:ENST00000396930(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006323"(DNA packaging)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070776"(MOZ/MORF histone acetyltransferase complex)|go:"GO:0090398"(cellular senescence)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR005818(Histone H1/H5)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR019787|interpro:IPR031280|interpro:IPR036388|interpro:IPR036390|interpro:IPR040706|mint:Q92794|rcsb pdb:1M36|rcsb pdb:2LN0|rcsb pdb:2OZU|rcsb pdb:2RC4|rcsb pdb:3V43|rcsb pdb:4LJN|rcsb pdb:4LK9|rcsb pdb:4LKA|rcsb pdb:4LLB|rcsb pdb:5B75|rcsb pdb:5B76|rcsb pdb:5B77|rcsb pdb:5B78|rcsb pdb:6LSB|reactome:R-HSA-3214847|reactome:R-HSA-6804758 psi-mi:"MI:0469"(intact) comment:Amino acids 2719 � 3969. An C-terminal cleavage product of 180 kDa, identifier Q03164-PRO_0000390950. Short name is p180.|chain-seq-start:2719|chain-seq-end:3969 - figure legend:Fig. 1e|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2010/09/14 2014/10/16 rogid:eI+u9uVhnzVAB4k4fks1BqNFDw09606 rogid:jPgi03a1G13Lv1IjZOz9vz1FvcY9606 intact-crc:8DA2B601E2194414|rigid:VNKZoovB0m8iJvRTZVuOMzCScjk false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q03164-PRO_0000390950 uniprotkb:Q92794 intact:EBI-2638616 intact:EBI-948013|intact:EBI-1048839|uniprotkb:Q76L81|ensembl:ENSP00000265713|ensembl:ENSP00000380136 psi-mi:q03164-pro_0000390950(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym) psi-mi:kat6a_human(display_long)|uniprotkb:KAT6A(gene name)|psi-mi:KAT6A(display_short)|uniprotkb:MOZ(gene name synonym)|uniprotkb:RUNXBP2(gene name synonym)|uniprotkb:ZNF220(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3(gene name synonym)|uniprotkb:Runt-related transcription factor-binding protein 2(gene name synonym)|uniprotkb:Monocytic leukemia zinc finger protein(gene name synonym)|uniprotkb:Zinc finger protein 220(gene name synonym)|uniprotkb:MYST3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Paggetti et al. (2010) imex:IM-15115|pubmed:20581860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1262"(I2D) intact:EBI-2927155|imex:IM-15115-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-591370(chain-parent) refseq:NP_006757.2|ensembl:ENSP00000265713|ensembl:ENSP00000380136|refseq:XP_016869352.1|refseq:XP_016869353.1|ensembl:ENSG00000083168(gene)|ensembl:ENST00000265713(transcript)|ensembl:ENST00000396930(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006323"(DNA packaging)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070776"(MOZ/MORF histone acetyltransferase complex)|go:"GO:0090398"(cellular senescence)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR005818(Histone H1/H5)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR019787|interpro:IPR031280|interpro:IPR036388|interpro:IPR036390|interpro:IPR040706|mint:Q92794|rcsb pdb:1M36|rcsb pdb:2LN0|rcsb pdb:2OZU|rcsb pdb:2RC4|rcsb pdb:3V43|rcsb pdb:4LJN|rcsb pdb:4LK9|rcsb pdb:4LKA|rcsb pdb:4LLB|rcsb pdb:5B75|rcsb pdb:5B76|rcsb pdb:5B77|rcsb pdb:5B78|rcsb pdb:6LSB|reactome:R-HSA-3214847|reactome:R-HSA-6804758 psi-mi:"MI:0469"(intact) comment:Amino acids 2719 � 3969. An C-terminal cleavage product of 180 kDa, identifier Q03164-PRO_0000390950. Short name is p180.|chain-seq-start:2719|chain-seq-end:3969 - figure legend:Fig. 1f|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2010/09/14 2014/10/16 rogid:eI+u9uVhnzVAB4k4fks1BqNFDw09606 rogid:jPgi03a1G13Lv1IjZOz9vz1FvcY9606 intact-crc:E5362AAF59A2244F|rigid:VNKZoovB0m8iJvRTZVuOMzCScjk false ha tag:?-? myc tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q03164-PRO_0000390949 uniprotkb:Q92794 intact:EBI-2610266 intact:EBI-948013|intact:EBI-1048839|uniprotkb:Q76L81|ensembl:ENSP00000265713|ensembl:ENSP00000380136 psi-mi:q03164-pro_0000390949(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym) psi-mi:kat6a_human(display_long)|uniprotkb:KAT6A(gene name)|psi-mi:KAT6A(display_short)|uniprotkb:MOZ(gene name synonym)|uniprotkb:RUNXBP2(gene name synonym)|uniprotkb:ZNF220(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3(gene name synonym)|uniprotkb:Runt-related transcription factor-binding protein 2(gene name synonym)|uniprotkb:Monocytic leukemia zinc finger protein(gene name synonym)|uniprotkb:Zinc finger protein 220(gene name synonym)|uniprotkb:MYST3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Paggetti et al. (2010) imex:IM-15115|pubmed:20581860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1262"(I2D) intact:EBI-2927218|imex:IM-15115-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-591370(chain-parent) refseq:NP_006757.2|ensembl:ENSP00000265713|ensembl:ENSP00000380136|refseq:XP_016869352.1|refseq:XP_016869353.1|ensembl:ENSG00000083168(gene)|ensembl:ENST00000265713(transcript)|ensembl:ENST00000396930(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006323"(DNA packaging)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070776"(MOZ/MORF histone acetyltransferase complex)|go:"GO:0090398"(cellular senescence)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR005818(Histone H1/H5)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR019787|interpro:IPR031280|interpro:IPR036388|interpro:IPR036390|interpro:IPR040706|mint:Q92794|rcsb pdb:1M36|rcsb pdb:2LN0|rcsb pdb:2OZU|rcsb pdb:2RC4|rcsb pdb:3V43|rcsb pdb:4LJN|rcsb pdb:4LK9|rcsb pdb:4LKA|rcsb pdb:4LLB|rcsb pdb:5B75|rcsb pdb:5B76|rcsb pdb:5B77|rcsb pdb:5B78|rcsb pdb:6LSB|reactome:R-HSA-3214847|reactome:R-HSA-6804758 psi-mi:"MI:0469"(intact) comment:Amino acids 1 � 2718. An N-terminal cleavage product of 320 kDa, identifier Q03164- PRO_0000390949. Short name is p320.|chain-seq-start:1|chain-seq-end:2718 - figure legend:Fig. S1a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2010/09/14 2014/10/16 rogid:GZYk2V0wLkKOYBBseAToOGGPT/s9606 rogid:jPgi03a1G13Lv1IjZOz9vz1FvcY9606 intact-crc:8FE1868BFBF766C8|rigid:Py19bHXUEhOa+ClZlNIeKSFU3a0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P61964 uniprotkb:Q92794 intact:EBI-540834|uniprotkb:Q91VA5|uniprotkb:Q9NWX7|uniprotkb:Q9UGP9|intact:EBI-28992503|ensembl:ENSP00000351446|intact:EBI-5774097 intact:EBI-948013|intact:EBI-1048839|uniprotkb:Q76L81|ensembl:ENSP00000265713|ensembl:ENSP00000380136 psi-mi:wdr5_human(display_long)|uniprotkb:BMP2-induced 3-kb gene protein(gene name synonym)|uniprotkb:WDR5(gene name)|psi-mi:WDR5(display_short)|uniprotkb:BIG3(gene name synonym) psi-mi:kat6a_human(display_long)|uniprotkb:KAT6A(gene name)|psi-mi:KAT6A(display_short)|uniprotkb:MOZ(gene name synonym)|uniprotkb:RUNXBP2(gene name synonym)|uniprotkb:ZNF220(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3(gene name synonym)|uniprotkb:Runt-related transcription factor-binding protein 2(gene name synonym)|uniprotkb:Monocytic leukemia zinc finger protein(gene name synonym)|uniprotkb:Zinc finger protein 220(gene name synonym)|uniprotkb:MYST3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Paggetti et al. (2010) imex:IM-15115|pubmed:20581860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1262"(I2D) intact:EBI-2927277|imex:IM-15115-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060058.1|refseq:NP_438172.1|rcsb pdb:4GMB|rcsb pdb:4IA9|rcsb pdb:4O45|rcsb pdb:4QL1|rcsb pdb:4Y7R|rcsb pdb:5EAL|rcsb pdb:5EAM|rcsb pdb:5EAP|rcsb pdb:5EAR|rcsb pdb:5M23|rcsb pdb:5M25|rcsb pdb:5SXM|rcsb pdb:5VFC|rcsb pdb:6BYN|rcsb pdb:6D9X|rcsb pdb:6DAI|rcsb pdb:6DAK|rcsb pdb:6DAR|rcsb pdb:6DAS|rcsb pdb:6DY7|rcsb pdb:6DYA|rcsb pdb:6E1Y|rcsb pdb:6E1Z|rcsb pdb:6E22|rcsb pdb:6E23|rcsb pdb:6IAM|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6OFZ|rcsb pdb:6OI0|rcsb pdb:6OI1|rcsb pdb:6OI2|rcsb pdb:6OI3|rcsb pdb:6PG3|rcsb pdb:6PG4|rcsb pdb:6PG5|rcsb pdb:6PG6|rcsb pdb:6PG7|rcsb pdb:6PG8|rcsb pdb:6PG9|rcsb pdb:6PGA|rcsb pdb:6PGB|rcsb pdb:6PGC|rcsb pdb:6PGD|rcsb pdb:6PGE|rcsb pdb:6PGF|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U5M|rcsb pdb:6U5Y|rcsb pdb:6U6W|rcsb pdb:6U80|rcsb pdb:6U8B|rcsb pdb:6U8L|rcsb pdb:6U8O|rcsb pdb:6UCS|rcsb pdb:6UFX|rcsb pdb:6UHY|rcsb pdb:6UHZ|rcsb pdb:6UIF|rcsb pdb:6UIK|rcsb pdb:6UJ4|rcsb pdb:6UJH|rcsb pdb:6UJJ|rcsb pdb:6UJL|rcsb pdb:6UOZ|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WJQ|rcsb pdb:7DNO|reactome:R-HSA-3214841|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5617472|reactome:R-HSA-8936459|reactome:R-HSA-8951664|ensembl:ENSG00000196363(gene)|ensembl:ENST00000358625(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0001501"(skeletal system development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P61964|rcsb pdb:2CNX|rcsb pdb:2CO0|rcsb pdb:2G99|rcsb pdb:2G9A|rcsb pdb:2GNQ|rcsb pdb:2H13|rcsb pdb:2H14|rcsb pdb:2H68|rcsb pdb:2H6K|rcsb pdb:2H6N|rcsb pdb:2H6Q|rcsb pdb:2H9L|rcsb pdb:2H9M|rcsb pdb:2H9N|rcsb pdb:2H9P|rcsb pdb:2O9K|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3MXX|rcsb pdb:3N0D|rcsb pdb:3N0E|rcsb pdb:3P4F|rcsb pdb:3PSL|rcsb pdb:3SMR|rcsb pdb:3UR4|rcsb pdb:3UVK|rcsb pdb:3UVL|rcsb pdb:3UVM|rcsb pdb:3UVN|rcsb pdb:3UVO|rcsb pdb:4A7J|rcsb pdb:4CY1|rcsb pdb:4CY2|rcsb pdb:4ERQ|rcsb pdb:4ERY|rcsb pdb:4ERZ|rcsb pdb:4ES0|rcsb pdb:4ESG|rcsb pdb:4EWR|rcsb pdb:4GM3|rcsb pdb:4GM8|rcsb pdb:4GM9|ensembl:ENSP00000351446|refseq:XP_005272220.1|dip:DIP-29223N refseq:NP_006757.2|ensembl:ENSP00000265713|ensembl:ENSP00000380136|refseq:XP_016869352.1|refseq:XP_016869353.1|ensembl:ENSG00000083168(gene)|ensembl:ENST00000265713(transcript)|ensembl:ENST00000396930(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006323"(DNA packaging)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070776"(MOZ/MORF histone acetyltransferase complex)|go:"GO:0090398"(cellular senescence)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR005818(Histone H1/H5)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR019787|interpro:IPR031280|interpro:IPR036388|interpro:IPR036390|interpro:IPR040706|mint:Q92794|rcsb pdb:1M36|rcsb pdb:2LN0|rcsb pdb:2OZU|rcsb pdb:2RC4|rcsb pdb:3V43|rcsb pdb:4LJN|rcsb pdb:4LK9|rcsb pdb:4LKA|rcsb pdb:4LLB|rcsb pdb:5B75|rcsb pdb:5B76|rcsb pdb:5B77|rcsb pdb:5B78|rcsb pdb:6LSB|reactome:R-HSA-3214847|reactome:R-HSA-6804758 psi-mi:"MI:0469"(intact) - - figure legend:Fig. 4b|antibodies:Monoclonal antibody used was generated against residues 856-870 of MOZ|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2010/09/14 2014/10/16 rogid:MNq7yCtkHPFRGiq1fP5TAwcGUAU9606 rogid:jPgi03a1G13Lv1IjZOz9vz1FvcY9606 intact-crc:34E749F1F75D2D6F|rigid:76v+57OxmlWBBWiuBJO4z4nVVRw false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q03164-PRO_0000390950 uniprotkb:P61964 intact:EBI-2638616 intact:EBI-540834|uniprotkb:Q91VA5|uniprotkb:Q9NWX7|uniprotkb:Q9UGP9|intact:EBI-28992503|ensembl:ENSP00000351446|intact:EBI-5774097 psi-mi:q03164-pro_0000390950(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym) psi-mi:wdr5_human(display_long)|uniprotkb:BMP2-induced 3-kb gene protein(gene name synonym)|uniprotkb:WDR5(gene name)|psi-mi:WDR5(display_short)|uniprotkb:BIG3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Paggetti et al. (2010) imex:IM-15115|pubmed:20581860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1262"(I2D) intact:EBI-2927281|imex:IM-15115-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-591370(chain-parent) refseq:NP_060058.1|refseq:NP_438172.1|rcsb pdb:4GMB|rcsb pdb:4IA9|rcsb pdb:4O45|rcsb pdb:4QL1|rcsb pdb:4Y7R|rcsb pdb:5EAL|rcsb pdb:5EAM|rcsb pdb:5EAP|rcsb pdb:5EAR|rcsb pdb:5M23|rcsb pdb:5M25|rcsb pdb:5SXM|rcsb pdb:5VFC|rcsb pdb:6BYN|rcsb pdb:6D9X|rcsb pdb:6DAI|rcsb pdb:6DAK|rcsb pdb:6DAR|rcsb pdb:6DAS|rcsb pdb:6DY7|rcsb pdb:6DYA|rcsb pdb:6E1Y|rcsb pdb:6E1Z|rcsb pdb:6E22|rcsb pdb:6E23|rcsb pdb:6IAM|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6OFZ|rcsb pdb:6OI0|rcsb pdb:6OI1|rcsb pdb:6OI2|rcsb pdb:6OI3|rcsb pdb:6PG3|rcsb pdb:6PG4|rcsb pdb:6PG5|rcsb pdb:6PG6|rcsb pdb:6PG7|rcsb pdb:6PG8|rcsb pdb:6PG9|rcsb pdb:6PGA|rcsb pdb:6PGB|rcsb pdb:6PGC|rcsb pdb:6PGD|rcsb pdb:6PGE|rcsb pdb:6PGF|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U5M|rcsb pdb:6U5Y|rcsb pdb:6U6W|rcsb pdb:6U80|rcsb pdb:6U8B|rcsb pdb:6U8L|rcsb pdb:6U8O|rcsb pdb:6UCS|rcsb pdb:6UFX|rcsb pdb:6UHY|rcsb pdb:6UHZ|rcsb pdb:6UIF|rcsb pdb:6UIK|rcsb pdb:6UJ4|rcsb pdb:6UJH|rcsb pdb:6UJJ|rcsb pdb:6UJL|rcsb pdb:6UOZ|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WJQ|rcsb pdb:7DNO|reactome:R-HSA-3214841|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5617472|reactome:R-HSA-8936459|reactome:R-HSA-8951664|ensembl:ENSG00000196363(gene)|ensembl:ENST00000358625(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0001501"(skeletal system development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P61964|rcsb pdb:2CNX|rcsb pdb:2CO0|rcsb pdb:2G99|rcsb pdb:2G9A|rcsb pdb:2GNQ|rcsb pdb:2H13|rcsb pdb:2H14|rcsb pdb:2H68|rcsb pdb:2H6K|rcsb pdb:2H6N|rcsb pdb:2H6Q|rcsb pdb:2H9L|rcsb pdb:2H9M|rcsb pdb:2H9N|rcsb pdb:2H9P|rcsb pdb:2O9K|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3MXX|rcsb pdb:3N0D|rcsb pdb:3N0E|rcsb pdb:3P4F|rcsb pdb:3PSL|rcsb pdb:3SMR|rcsb pdb:3UR4|rcsb pdb:3UVK|rcsb pdb:3UVL|rcsb pdb:3UVM|rcsb pdb:3UVN|rcsb pdb:3UVO|rcsb pdb:4A7J|rcsb pdb:4CY1|rcsb pdb:4CY2|rcsb pdb:4ERQ|rcsb pdb:4ERY|rcsb pdb:4ERZ|rcsb pdb:4ES0|rcsb pdb:4ESG|rcsb pdb:4EWR|rcsb pdb:4GM3|rcsb pdb:4GM8|rcsb pdb:4GM9|ensembl:ENSP00000351446|refseq:XP_005272220.1|dip:DIP-29223N psi-mi:"MI:0469"(intact) comment:Amino acids 2719 � 3969. An C-terminal cleavage product of 180 kDa, identifier Q03164-PRO_0000390950. Short name is p180.|chain-seq-start:2719|chain-seq-end:3969 - figure legend:Fig. 4b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2010/09/14 2014/10/16 rogid:eI+u9uVhnzVAB4k4fks1BqNFDw09606 rogid:MNq7yCtkHPFRGiq1fP5TAwcGUAU9606 intact-crc:EF1C118EC3BF9508|rigid:D4StIvTsUfdtg99+bsf1NpyMtKk false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q92794 uniprotkb:Q03164-PRO_0000390950 intact:EBI-948013|intact:EBI-1048839|uniprotkb:Q76L81|ensembl:ENSP00000265713|ensembl:ENSP00000380136 intact:EBI-2638616 psi-mi:kat6a_human(display_long)|uniprotkb:KAT6A(gene name)|psi-mi:KAT6A(display_short)|uniprotkb:MOZ(gene name synonym)|uniprotkb:RUNXBP2(gene name synonym)|uniprotkb:ZNF220(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3(gene name synonym)|uniprotkb:Runt-related transcription factor-binding protein 2(gene name synonym)|uniprotkb:Monocytic leukemia zinc finger protein(gene name synonym)|uniprotkb:Zinc finger protein 220(gene name synonym)|uniprotkb:MYST3(gene name synonym) psi-mi:q03164-pro_0000390950(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Paggetti et al. (2010) imex:IM-15115|pubmed:20581860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1262"(I2D) intact:EBI-2927132|imex:IM-15115-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006757.2|ensembl:ENSP00000265713|ensembl:ENSP00000380136|refseq:XP_016869352.1|refseq:XP_016869353.1|ensembl:ENSG00000083168(gene)|ensembl:ENST00000265713(transcript)|ensembl:ENST00000396930(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006323"(DNA packaging)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070776"(MOZ/MORF histone acetyltransferase complex)|go:"GO:0090398"(cellular senescence)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR005818(Histone H1/H5)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR019787|interpro:IPR031280|interpro:IPR036388|interpro:IPR036390|interpro:IPR040706|mint:Q92794|rcsb pdb:1M36|rcsb pdb:2LN0|rcsb pdb:2OZU|rcsb pdb:2RC4|rcsb pdb:3V43|rcsb pdb:4LJN|rcsb pdb:4LK9|rcsb pdb:4LKA|rcsb pdb:4LLB|rcsb pdb:5B75|rcsb pdb:5B76|rcsb pdb:5B77|rcsb pdb:5B78|rcsb pdb:6LSB|reactome:R-HSA-3214847|reactome:R-HSA-6804758 intact:EBI-591370(chain-parent) psi-mi:"MI:0469"(intact) - comment:Amino acids 2719 � 3969. An C-terminal cleavage product of 180 kDa, identifier Q03164-PRO_0000390950. Short name is p180.|chain-seq-start:2719|chain-seq-end:3969 figure legend:Fig. 1d|antibodies:Monoclonal antibody used was generated against residues 856-870 of MOZ|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.) - 2010/09/14 2014/10/16 rogid:jPgi03a1G13Lv1IjZOz9vz1FvcY9606 rogid:eI+u9uVhnzVAB4k4fks1BqNFDw09606 intact-crc:4DE0D068A46B7360|rigid:VNKZoovB0m8iJvRTZVuOMzCScjk false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q92794 uniprotkb:P61964 intact:EBI-948013|intact:EBI-1048839|uniprotkb:Q76L81|ensembl:ENSP00000265713|ensembl:ENSP00000380136 intact:EBI-540834|uniprotkb:Q91VA5|uniprotkb:Q9NWX7|uniprotkb:Q9UGP9|intact:EBI-28992503|ensembl:ENSP00000351446|intact:EBI-5774097 psi-mi:kat6a_human(display_long)|uniprotkb:KAT6A(gene name)|psi-mi:KAT6A(display_short)|uniprotkb:MOZ(gene name synonym)|uniprotkb:RUNXBP2(gene name synonym)|uniprotkb:ZNF220(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3(gene name synonym)|uniprotkb:Runt-related transcription factor-binding protein 2(gene name synonym)|uniprotkb:Monocytic leukemia zinc finger protein(gene name synonym)|uniprotkb:Zinc finger protein 220(gene name synonym)|uniprotkb:MYST3(gene name synonym) psi-mi:wdr5_human(display_long)|uniprotkb:BMP2-induced 3-kb gene protein(gene name synonym)|uniprotkb:WDR5(gene name)|psi-mi:WDR5(display_short)|uniprotkb:BIG3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Paggetti et al. (2010) imex:IM-15115|pubmed:20581860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1262"(I2D) intact:EBI-2927303|imex:IM-15115-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006757.2|ensembl:ENSP00000265713|ensembl:ENSP00000380136|refseq:XP_016869352.1|refseq:XP_016869353.1|ensembl:ENSG00000083168(gene)|ensembl:ENST00000265713(transcript)|ensembl:ENST00000396930(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006323"(DNA packaging)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070776"(MOZ/MORF histone acetyltransferase complex)|go:"GO:0090398"(cellular senescence)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR005818(Histone H1/H5)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR019787|interpro:IPR031280|interpro:IPR036388|interpro:IPR036390|interpro:IPR040706|mint:Q92794|rcsb pdb:1M36|rcsb pdb:2LN0|rcsb pdb:2OZU|rcsb pdb:2RC4|rcsb pdb:3V43|rcsb pdb:4LJN|rcsb pdb:4LK9|rcsb pdb:4LKA|rcsb pdb:4LLB|rcsb pdb:5B75|rcsb pdb:5B76|rcsb pdb:5B77|rcsb pdb:5B78|rcsb pdb:6LSB|reactome:R-HSA-3214847|reactome:R-HSA-6804758 refseq:NP_060058.1|refseq:NP_438172.1|rcsb pdb:4GMB|rcsb pdb:4IA9|rcsb pdb:4O45|rcsb pdb:4QL1|rcsb pdb:4Y7R|rcsb pdb:5EAL|rcsb pdb:5EAM|rcsb pdb:5EAP|rcsb pdb:5EAR|rcsb pdb:5M23|rcsb pdb:5M25|rcsb pdb:5SXM|rcsb pdb:5VFC|rcsb pdb:6BYN|rcsb pdb:6D9X|rcsb pdb:6DAI|rcsb pdb:6DAK|rcsb pdb:6DAR|rcsb pdb:6DAS|rcsb pdb:6DY7|rcsb pdb:6DYA|rcsb pdb:6E1Y|rcsb pdb:6E1Z|rcsb pdb:6E22|rcsb pdb:6E23|rcsb pdb:6IAM|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6OFZ|rcsb pdb:6OI0|rcsb pdb:6OI1|rcsb pdb:6OI2|rcsb pdb:6OI3|rcsb pdb:6PG3|rcsb pdb:6PG4|rcsb pdb:6PG5|rcsb pdb:6PG6|rcsb pdb:6PG7|rcsb pdb:6PG8|rcsb pdb:6PG9|rcsb pdb:6PGA|rcsb pdb:6PGB|rcsb pdb:6PGC|rcsb pdb:6PGD|rcsb pdb:6PGE|rcsb pdb:6PGF|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U5M|rcsb pdb:6U5Y|rcsb pdb:6U6W|rcsb pdb:6U80|rcsb pdb:6U8B|rcsb pdb:6U8L|rcsb pdb:6U8O|rcsb pdb:6UCS|rcsb pdb:6UFX|rcsb pdb:6UHY|rcsb pdb:6UHZ|rcsb pdb:6UIF|rcsb pdb:6UIK|rcsb pdb:6UJ4|rcsb pdb:6UJH|rcsb pdb:6UJJ|rcsb pdb:6UJL|rcsb pdb:6UOZ|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WJQ|rcsb pdb:7DNO|reactome:R-HSA-3214841|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5617472|reactome:R-HSA-8936459|reactome:R-HSA-8951664|ensembl:ENSG00000196363(gene)|ensembl:ENST00000358625(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0001501"(skeletal system development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P61964|rcsb pdb:2CNX|rcsb pdb:2CO0|rcsb pdb:2G99|rcsb pdb:2G9A|rcsb pdb:2GNQ|rcsb pdb:2H13|rcsb pdb:2H14|rcsb pdb:2H68|rcsb pdb:2H6K|rcsb pdb:2H6N|rcsb pdb:2H6Q|rcsb pdb:2H9L|rcsb pdb:2H9M|rcsb pdb:2H9N|rcsb pdb:2H9P|rcsb pdb:2O9K|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3MXX|rcsb pdb:3N0D|rcsb pdb:3N0E|rcsb pdb:3P4F|rcsb pdb:3PSL|rcsb pdb:3SMR|rcsb pdb:3UR4|rcsb pdb:3UVK|rcsb pdb:3UVL|rcsb pdb:3UVM|rcsb pdb:3UVN|rcsb pdb:3UVO|rcsb pdb:4A7J|rcsb pdb:4CY1|rcsb pdb:4CY2|rcsb pdb:4ERQ|rcsb pdb:4ERY|rcsb pdb:4ERZ|rcsb pdb:4ES0|rcsb pdb:4ESG|rcsb pdb:4EWR|rcsb pdb:4GM3|rcsb pdb:4GM8|rcsb pdb:4GM9|ensembl:ENSP00000351446|refseq:XP_005272220.1|dip:DIP-29223N psi-mi:"MI:0469"(intact) - - figure legend:Fig. 4c|antibodies:Monoclonal antibody used was generated against residues 856-870 of MOZ|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.) - 2010/09/14 2014/10/16 rogid:jPgi03a1G13Lv1IjZOz9vz1FvcY9606 rogid:MNq7yCtkHPFRGiq1fP5TAwcGUAU9606 intact-crc:E5CC537C68330E1A|rigid:76v+57OxmlWBBWiuBJO4z4nVVRw false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P61964 uniprotkb:Q03164-PRO_0000390950 intact:EBI-540834|uniprotkb:Q91VA5|uniprotkb:Q9NWX7|uniprotkb:Q9UGP9|intact:EBI-28992503|ensembl:ENSP00000351446|intact:EBI-5774097 intact:EBI-2638616 psi-mi:wdr5_human(display_long)|uniprotkb:BMP2-induced 3-kb gene protein(gene name synonym)|uniprotkb:WDR5(gene name)|psi-mi:WDR5(display_short)|uniprotkb:BIG3(gene name synonym) psi-mi:q03164-pro_0000390950(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Paggetti et al. (2010) imex:IM-15115|pubmed:20581860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1262"(I2D) intact:EBI-2927307|imex:IM-15115-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060058.1|refseq:NP_438172.1|rcsb pdb:4GMB|rcsb pdb:4IA9|rcsb pdb:4O45|rcsb pdb:4QL1|rcsb pdb:4Y7R|rcsb pdb:5EAL|rcsb pdb:5EAM|rcsb pdb:5EAP|rcsb pdb:5EAR|rcsb pdb:5M23|rcsb pdb:5M25|rcsb pdb:5SXM|rcsb pdb:5VFC|rcsb pdb:6BYN|rcsb pdb:6D9X|rcsb pdb:6DAI|rcsb pdb:6DAK|rcsb pdb:6DAR|rcsb pdb:6DAS|rcsb pdb:6DY7|rcsb pdb:6DYA|rcsb pdb:6E1Y|rcsb pdb:6E1Z|rcsb pdb:6E22|rcsb pdb:6E23|rcsb pdb:6IAM|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6OFZ|rcsb pdb:6OI0|rcsb pdb:6OI1|rcsb pdb:6OI2|rcsb pdb:6OI3|rcsb pdb:6PG3|rcsb pdb:6PG4|rcsb pdb:6PG5|rcsb pdb:6PG6|rcsb pdb:6PG7|rcsb pdb:6PG8|rcsb pdb:6PG9|rcsb pdb:6PGA|rcsb pdb:6PGB|rcsb pdb:6PGC|rcsb pdb:6PGD|rcsb pdb:6PGE|rcsb pdb:6PGF|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U5M|rcsb pdb:6U5Y|rcsb pdb:6U6W|rcsb pdb:6U80|rcsb pdb:6U8B|rcsb pdb:6U8L|rcsb pdb:6U8O|rcsb pdb:6UCS|rcsb pdb:6UFX|rcsb pdb:6UHY|rcsb pdb:6UHZ|rcsb pdb:6UIF|rcsb pdb:6UIK|rcsb pdb:6UJ4|rcsb pdb:6UJH|rcsb pdb:6UJJ|rcsb pdb:6UJL|rcsb pdb:6UOZ|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WJQ|rcsb pdb:7DNO|reactome:R-HSA-3214841|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5617472|reactome:R-HSA-8936459|reactome:R-HSA-8951664|ensembl:ENSG00000196363(gene)|ensembl:ENST00000358625(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0001501"(skeletal system development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P61964|rcsb pdb:2CNX|rcsb pdb:2CO0|rcsb pdb:2G99|rcsb pdb:2G9A|rcsb pdb:2GNQ|rcsb pdb:2H13|rcsb pdb:2H14|rcsb pdb:2H68|rcsb pdb:2H6K|rcsb pdb:2H6N|rcsb pdb:2H6Q|rcsb pdb:2H9L|rcsb pdb:2H9M|rcsb pdb:2H9N|rcsb pdb:2H9P|rcsb pdb:2O9K|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3MXX|rcsb pdb:3N0D|rcsb pdb:3N0E|rcsb pdb:3P4F|rcsb pdb:3PSL|rcsb pdb:3SMR|rcsb pdb:3UR4|rcsb pdb:3UVK|rcsb pdb:3UVL|rcsb pdb:3UVM|rcsb pdb:3UVN|rcsb pdb:3UVO|rcsb pdb:4A7J|rcsb pdb:4CY1|rcsb pdb:4CY2|rcsb pdb:4ERQ|rcsb pdb:4ERY|rcsb pdb:4ERZ|rcsb pdb:4ES0|rcsb pdb:4ESG|rcsb pdb:4EWR|rcsb pdb:4GM3|rcsb pdb:4GM8|rcsb pdb:4GM9|ensembl:ENSP00000351446|refseq:XP_005272220.1|dip:DIP-29223N intact:EBI-591370(chain-parent) psi-mi:"MI:0469"(intact) - comment:Amino acids 2719 � 3969. An C-terminal cleavage product of 180 kDa, identifier Q03164-PRO_0000390950. Short name is p180.|chain-seq-start:2719|chain-seq-end:3969 figure legend:Fig. 4c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-k_562)|taxid:9606(Homo sapiens myeloid leukemia cells.) - 2010/09/14 2014/10/16 rogid:MNq7yCtkHPFRGiq1fP5TAwcGUAU9606 rogid:eI+u9uVhnzVAB4k4fks1BqNFDw09606 intact-crc:BDE9613578FA2F48|rigid:D4StIvTsUfdtg99+bsf1NpyMtKk false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q92794 uniprotkb:Q03164-PRO_0000390950 intact:EBI-948013|intact:EBI-1048839|uniprotkb:Q76L81|ensembl:ENSP00000265713|ensembl:ENSP00000380136 intact:EBI-2638616 psi-mi:kat6a_human(display_long)|uniprotkb:KAT6A(gene name)|psi-mi:KAT6A(display_short)|uniprotkb:MOZ(gene name synonym)|uniprotkb:RUNXBP2(gene name synonym)|uniprotkb:ZNF220(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3(gene name synonym)|uniprotkb:Runt-related transcription factor-binding protein 2(gene name synonym)|uniprotkb:Monocytic leukemia zinc finger protein(gene name synonym)|uniprotkb:Zinc finger protein 220(gene name synonym)|uniprotkb:MYST3(gene name synonym) psi-mi:q03164-pro_0000390950(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Paggetti et al. (2010) imex:IM-15115|pubmed:20581860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1262"(I2D) intact:EBI-2927167|imex:IM-15115-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006757.2|ensembl:ENSP00000265713|ensembl:ENSP00000380136|refseq:XP_016869352.1|refseq:XP_016869353.1|ensembl:ENSG00000083168(gene)|ensembl:ENST00000265713(transcript)|ensembl:ENST00000396930(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006323"(DNA packaging)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070776"(MOZ/MORF histone acetyltransferase complex)|go:"GO:0090398"(cellular senescence)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR005818(Histone H1/H5)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR019787|interpro:IPR031280|interpro:IPR036388|interpro:IPR036390|interpro:IPR040706|mint:Q92794|rcsb pdb:1M36|rcsb pdb:2LN0|rcsb pdb:2OZU|rcsb pdb:2RC4|rcsb pdb:3V43|rcsb pdb:4LJN|rcsb pdb:4LK9|rcsb pdb:4LKA|rcsb pdb:4LLB|rcsb pdb:5B75|rcsb pdb:5B76|rcsb pdb:5B77|rcsb pdb:5B78|rcsb pdb:6LSB|reactome:R-HSA-3214847|reactome:R-HSA-6804758 intact:EBI-591370(chain-parent) psi-mi:"MI:0469"(intact) - comment:Amino acids 2719 � 3969. An C-terminal cleavage product of 180 kDa, identifier Q03164-PRO_0000390950. Short name is p180.|chain-seq-start:2719|chain-seq-end:3969 figure legend:Fig. 1g|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2010/09/14 2014/10/16 rogid:jPgi03a1G13Lv1IjZOz9vz1FvcY9606 rogid:eI+u9uVhnzVAB4k4fks1BqNFDw09606 intact-crc:678BAD8151627B85|rigid:VNKZoovB0m8iJvRTZVuOMzCScjk false myc tag:?-? ha tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q03164-PRO_0000390950 uniprotkb:Q92794 intact:EBI-2638616 intact:EBI-948013|intact:EBI-1048839|uniprotkb:Q76L81|ensembl:ENSP00000265713|ensembl:ENSP00000380136 psi-mi:q03164-pro_0000390950(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym) psi-mi:kat6a_human(display_long)|uniprotkb:KAT6A(gene name)|psi-mi:KAT6A(display_short)|uniprotkb:MOZ(gene name synonym)|uniprotkb:RUNXBP2(gene name synonym)|uniprotkb:ZNF220(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3(gene name synonym)|uniprotkb:Runt-related transcription factor-binding protein 2(gene name synonym)|uniprotkb:Monocytic leukemia zinc finger protein(gene name synonym)|uniprotkb:Zinc finger protein 220(gene name synonym)|uniprotkb:MYST3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Paggetti et al. (2010) imex:IM-15115|pubmed:20581860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1262"(I2D) intact:EBI-2927203|imex:IM-15115-14 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-591370(chain-parent) refseq:NP_006757.2|ensembl:ENSP00000265713|ensembl:ENSP00000380136|refseq:XP_016869352.1|refseq:XP_016869353.1|ensembl:ENSG00000083168(gene)|ensembl:ENST00000265713(transcript)|ensembl:ENST00000396930(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006323"(DNA packaging)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070776"(MOZ/MORF histone acetyltransferase complex)|go:"GO:0090398"(cellular senescence)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR005818(Histone H1/H5)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR019787|interpro:IPR031280|interpro:IPR036388|interpro:IPR036390|interpro:IPR040706|mint:Q92794|rcsb pdb:1M36|rcsb pdb:2LN0|rcsb pdb:2OZU|rcsb pdb:2RC4|rcsb pdb:3V43|rcsb pdb:4LJN|rcsb pdb:4LK9|rcsb pdb:4LKA|rcsb pdb:4LLB|rcsb pdb:5B75|rcsb pdb:5B76|rcsb pdb:5B77|rcsb pdb:5B78|rcsb pdb:6LSB|reactome:R-HSA-3214847|reactome:R-HSA-6804758 psi-mi:"MI:0469"(intact) comment:Amino acids 2719 � 3969. An C-terminal cleavage product of 180 kDa, identifier Q03164-PRO_0000390950. Short name is p180.|chain-seq-start:2719|chain-seq-end:3969 - figure legend:Fig. 1i|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2010/09/14 2014/10/16 rogid:eI+u9uVhnzVAB4k4fks1BqNFDw09606 rogid:jPgi03a1G13Lv1IjZOz9vz1FvcY9606 intact-crc:052E3FC3DD02B093|rigid:VNKZoovB0m8iJvRTZVuOMzCScjk false ha tag:?-? flag tag:?-?|sufficient binding region:353-760 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q92794 uniprotkb:P61964 intact:EBI-948013|intact:EBI-1048839|uniprotkb:Q76L81|ensembl:ENSP00000265713|ensembl:ENSP00000380136 intact:EBI-540834|uniprotkb:Q91VA5|uniprotkb:Q9NWX7|uniprotkb:Q9UGP9|intact:EBI-28992503|ensembl:ENSP00000351446|intact:EBI-5774097 psi-mi:kat6a_human(display_long)|uniprotkb:KAT6A(gene name)|psi-mi:KAT6A(display_short)|uniprotkb:MOZ(gene name synonym)|uniprotkb:RUNXBP2(gene name synonym)|uniprotkb:ZNF220(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3(gene name synonym)|uniprotkb:Runt-related transcription factor-binding protein 2(gene name synonym)|uniprotkb:Monocytic leukemia zinc finger protein(gene name synonym)|uniprotkb:Zinc finger protein 220(gene name synonym)|uniprotkb:MYST3(gene name synonym) psi-mi:wdr5_human(display_long)|uniprotkb:BMP2-induced 3-kb gene protein(gene name synonym)|uniprotkb:WDR5(gene name)|psi-mi:WDR5(display_short)|uniprotkb:BIG3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Paggetti et al. (2010) imex:IM-15115|pubmed:20581860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1262"(I2D) intact:EBI-2927286|imex:IM-15115-16 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006757.2|ensembl:ENSP00000265713|ensembl:ENSP00000380136|refseq:XP_016869352.1|refseq:XP_016869353.1|ensembl:ENSG00000083168(gene)|ensembl:ENST00000265713(transcript)|ensembl:ENST00000396930(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006323"(DNA packaging)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070776"(MOZ/MORF histone acetyltransferase complex)|go:"GO:0090398"(cellular senescence)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR005818(Histone H1/H5)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR019787|interpro:IPR031280|interpro:IPR036388|interpro:IPR036390|interpro:IPR040706|mint:Q92794|rcsb pdb:1M36|rcsb pdb:2LN0|rcsb pdb:2OZU|rcsb pdb:2RC4|rcsb pdb:3V43|rcsb pdb:4LJN|rcsb pdb:4LK9|rcsb pdb:4LKA|rcsb pdb:4LLB|rcsb pdb:5B75|rcsb pdb:5B76|rcsb pdb:5B77|rcsb pdb:5B78|rcsb pdb:6LSB|reactome:R-HSA-3214847|reactome:R-HSA-6804758 refseq:NP_060058.1|refseq:NP_438172.1|rcsb pdb:4GMB|rcsb pdb:4IA9|rcsb pdb:4O45|rcsb pdb:4QL1|rcsb pdb:4Y7R|rcsb pdb:5EAL|rcsb pdb:5EAM|rcsb pdb:5EAP|rcsb pdb:5EAR|rcsb pdb:5M23|rcsb pdb:5M25|rcsb pdb:5SXM|rcsb pdb:5VFC|rcsb pdb:6BYN|rcsb pdb:6D9X|rcsb pdb:6DAI|rcsb pdb:6DAK|rcsb pdb:6DAR|rcsb pdb:6DAS|rcsb pdb:6DY7|rcsb pdb:6DYA|rcsb pdb:6E1Y|rcsb pdb:6E1Z|rcsb pdb:6E22|rcsb pdb:6E23|rcsb pdb:6IAM|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6OFZ|rcsb pdb:6OI0|rcsb pdb:6OI1|rcsb pdb:6OI2|rcsb pdb:6OI3|rcsb pdb:6PG3|rcsb pdb:6PG4|rcsb pdb:6PG5|rcsb pdb:6PG6|rcsb pdb:6PG7|rcsb pdb:6PG8|rcsb pdb:6PG9|rcsb pdb:6PGA|rcsb pdb:6PGB|rcsb pdb:6PGC|rcsb pdb:6PGD|rcsb pdb:6PGE|rcsb pdb:6PGF|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U5M|rcsb pdb:6U5Y|rcsb pdb:6U6W|rcsb pdb:6U80|rcsb pdb:6U8B|rcsb pdb:6U8L|rcsb pdb:6U8O|rcsb pdb:6UCS|rcsb pdb:6UFX|rcsb pdb:6UHY|rcsb pdb:6UHZ|rcsb pdb:6UIF|rcsb pdb:6UIK|rcsb pdb:6UJ4|rcsb pdb:6UJH|rcsb pdb:6UJJ|rcsb pdb:6UJL|rcsb pdb:6UOZ|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WJQ|rcsb pdb:7DNO|reactome:R-HSA-3214841|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5617472|reactome:R-HSA-8936459|reactome:R-HSA-8951664|ensembl:ENSG00000196363(gene)|ensembl:ENST00000358625(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0001501"(skeletal system development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P61964|rcsb pdb:2CNX|rcsb pdb:2CO0|rcsb pdb:2G99|rcsb pdb:2G9A|rcsb pdb:2GNQ|rcsb pdb:2H13|rcsb pdb:2H14|rcsb pdb:2H68|rcsb pdb:2H6K|rcsb pdb:2H6N|rcsb pdb:2H6Q|rcsb pdb:2H9L|rcsb pdb:2H9M|rcsb pdb:2H9N|rcsb pdb:2H9P|rcsb pdb:2O9K|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3MXX|rcsb pdb:3N0D|rcsb pdb:3N0E|rcsb pdb:3P4F|rcsb pdb:3PSL|rcsb pdb:3SMR|rcsb pdb:3UR4|rcsb pdb:3UVK|rcsb pdb:3UVL|rcsb pdb:3UVM|rcsb pdb:3UVN|rcsb pdb:3UVO|rcsb pdb:4A7J|rcsb pdb:4CY1|rcsb pdb:4CY2|rcsb pdb:4ERQ|rcsb pdb:4ERY|rcsb pdb:4ERZ|rcsb pdb:4ES0|rcsb pdb:4ESG|rcsb pdb:4EWR|rcsb pdb:4GM3|rcsb pdb:4GM8|rcsb pdb:4GM9|ensembl:ENSP00000351446|refseq:XP_005272220.1|dip:DIP-29223N psi-mi:"MI:0469"(intact) - - figure legend:Fig. 4d|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2010/09/14 2014/10/16 rogid:jPgi03a1G13Lv1IjZOz9vz1FvcY9606 rogid:MNq7yCtkHPFRGiq1fP5TAwcGUAU9606 intact-crc:494FBFB91C083053|rigid:76v+57OxmlWBBWiuBJO4z4nVVRw false sufficient binding region:1-352|necessary binding region:1409-2004|flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q92794 uniprotkb:Q03164-PRO_0000390950 intact:EBI-948013|intact:EBI-1048839|uniprotkb:Q76L81|ensembl:ENSP00000265713|ensembl:ENSP00000380136 intact:EBI-2638616 psi-mi:kat6a_human(display_long)|uniprotkb:KAT6A(gene name)|psi-mi:KAT6A(display_short)|uniprotkb:MOZ(gene name synonym)|uniprotkb:RUNXBP2(gene name synonym)|uniprotkb:ZNF220(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3(gene name synonym)|uniprotkb:Runt-related transcription factor-binding protein 2(gene name synonym)|uniprotkb:Monocytic leukemia zinc finger protein(gene name synonym)|uniprotkb:Zinc finger protein 220(gene name synonym)|uniprotkb:MYST3(gene name synonym) psi-mi:q03164-pro_0000390950(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Paggetti et al. (2010) imex:IM-15115|pubmed:20581860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1262"(I2D) intact:EBI-2927182|imex:IM-15115-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006757.2|ensembl:ENSP00000265713|ensembl:ENSP00000380136|refseq:XP_016869352.1|refseq:XP_016869353.1|ensembl:ENSG00000083168(gene)|ensembl:ENST00000265713(transcript)|ensembl:ENST00000396930(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006323"(DNA packaging)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070776"(MOZ/MORF histone acetyltransferase complex)|go:"GO:0090398"(cellular senescence)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR005818(Histone H1/H5)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR019787|interpro:IPR031280|interpro:IPR036388|interpro:IPR036390|interpro:IPR040706|mint:Q92794|rcsb pdb:1M36|rcsb pdb:2LN0|rcsb pdb:2OZU|rcsb pdb:2RC4|rcsb pdb:3V43|rcsb pdb:4LJN|rcsb pdb:4LK9|rcsb pdb:4LKA|rcsb pdb:4LLB|rcsb pdb:5B75|rcsb pdb:5B76|rcsb pdb:5B77|rcsb pdb:5B78|rcsb pdb:6LSB|reactome:R-HSA-3214847|reactome:R-HSA-6804758 intact:EBI-591370(chain-parent) psi-mi:"MI:0469"(intact) - comment:Amino acids 2719 � 3969. An C-terminal cleavage product of 180 kDa, identifier Q03164-PRO_0000390950. Short name is p180.|chain-seq-start:2719|chain-seq-end:3969 figure legend:Fig. 1h|antibodies:Monoclonal antibody used was generated against residues 856-870 of MOZ|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-pbmc)|taxid:9606(Human Peripheral Blood Mononuclear cell) - 2010/09/14 2014/10/16 rogid:jPgi03a1G13Lv1IjZOz9vz1FvcY9606 rogid:eI+u9uVhnzVAB4k4fks1BqNFDw09606 intact-crc:342C81E4BF4B5502|rigid:VNKZoovB0m8iJvRTZVuOMzCScjk false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q03164 ensembl:ENSG00000106004 intact:EBI-591370|ensembl:ENSP00000374157|uniprotkb:Q13743|uniprotkb:Q13744|uniprotkb:Q14845|uniprotkb:Q16364|uniprotkb:Q6UBD1|uniprotkb:Q9UMA3|intact:EBI-2614650|uniprotkb:Q59FF2|uniprotkb:Q9UD94|uniprotkb:E9PQG7|uniprotkb:Q9HBJ3 intact:EBI-2927244 psi-mi:kmt2a_human(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym) psi-mi:hoxa5_human_gene(display_short)|psi-mi:ENSG00000106004(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Paggetti et al. (2010) imex:IM-15115|pubmed:20581860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1262"(I2D) intact:EBI-2927240|imex:IM-15115-18 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) go:"GO:2000615"(regulation of histone H3-K9 acetylation)|interpro:IPR001214(SET)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|interpro:IPR036427|interpro:IPR037927|interpro:IPR041958|interpro:IPR042023|interpro:IPR042025|interpro:IPR044133|mint:Q03164|rcsb pdb:2AGH|rcsb pdb:2J2S|rcsb pdb:2JYI|rcsb pdb:2KKF|rcsb pdb:2KU7|rcsb pdb:2KYU|rcsb pdb:2LXS|rcsb pdb:2LXT|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2W5Y|ensembl:ENSG00000118058(gene)|ensembl:ENST00000389506(transcript)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071440"(regulation of histone H3-K14 acetylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|go:"GO:1905642"(negative regulation of DNA methylation)|refseq:NP_001184033.1|refseq:NP_005924.2|ensembl:ENSP00000374157|ensembl:ENST00000534358|ensembl:ENSP00000436786|ensembl:ENST00000649699|ensembl:ENSP00000496927|dip:DIP-29221N|rcsb pdb:2W5Z|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3LQH|rcsb pdb:3LQI|rcsb pdb:3LQJ|rcsb pdb:3P4F|rcsb pdb:3U85|rcsb pdb:3U88|rcsb pdb:4ESG|rcsb pdb:4GQ6|rcsb pdb:4NW3|rcsb pdb:5F5E|rcsb pdb:5F6L|rcsb pdb:5SVH|rcsb pdb:6EMQ|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U9K|rcsb pdb:6U9M|rcsb pdb:6U9N|rcsb pdb:6U9R|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|reactome:R-HSA-3214841|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9616222 - - - - figure legend:Fig. 3b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2010/09/14 2014/10/16 rogid:r9J9pjnLZI7GCBSHYqnmzjv9WvM9606 - intact-crc:AA8318EBCF190255 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q03164 ensembl:ENSG00000122592 intact:EBI-591370|ensembl:ENSP00000374157|uniprotkb:Q13743|uniprotkb:Q13744|uniprotkb:Q14845|uniprotkb:Q16364|uniprotkb:Q6UBD1|uniprotkb:Q9UMA3|intact:EBI-2614650|uniprotkb:Q59FF2|uniprotkb:Q9UD94|uniprotkb:E9PQG7|uniprotkb:Q9HBJ3 intact:EBI-1801907 psi-mi:kmt2a_human(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym) psi-mi:hoxa7_human_gene(display_short)|psi-mi:ENSG00000122592(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Paggetti et al. (2010) imex:IM-15115|pubmed:20581860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1262"(I2D) intact:EBI-2927247|imex:IM-15115-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) go:"GO:2000615"(regulation of histone H3-K9 acetylation)|interpro:IPR001214(SET)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|interpro:IPR036427|interpro:IPR037927|interpro:IPR041958|interpro:IPR042023|interpro:IPR042025|interpro:IPR044133|mint:Q03164|rcsb pdb:2AGH|rcsb pdb:2J2S|rcsb pdb:2JYI|rcsb pdb:2KKF|rcsb pdb:2KU7|rcsb pdb:2KYU|rcsb pdb:2LXS|rcsb pdb:2LXT|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2W5Y|ensembl:ENSG00000118058(gene)|ensembl:ENST00000389506(transcript)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071440"(regulation of histone H3-K14 acetylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|go:"GO:1905642"(negative regulation of DNA methylation)|refseq:NP_001184033.1|refseq:NP_005924.2|ensembl:ENSP00000374157|ensembl:ENST00000534358|ensembl:ENSP00000436786|ensembl:ENST00000649699|ensembl:ENSP00000496927|dip:DIP-29221N|rcsb pdb:2W5Z|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3LQH|rcsb pdb:3LQI|rcsb pdb:3LQJ|rcsb pdb:3P4F|rcsb pdb:3U85|rcsb pdb:3U88|rcsb pdb:4ESG|rcsb pdb:4GQ6|rcsb pdb:4NW3|rcsb pdb:5F5E|rcsb pdb:5F6L|rcsb pdb:5SVH|rcsb pdb:6EMQ|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U9K|rcsb pdb:6U9M|rcsb pdb:6U9N|rcsb pdb:6U9R|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|reactome:R-HSA-3214841|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9616222 - - - - figure legend:Fig. 3b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2010/09/14 2014/10/16 rogid:r9J9pjnLZI7GCBSHYqnmzjv9WvM9606 - intact-crc:E86DACDE9F1181E8 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q03164 ensembl:ENSG00000078399 intact:EBI-591370|ensembl:ENSP00000374157|uniprotkb:Q13743|uniprotkb:Q13744|uniprotkb:Q14845|uniprotkb:Q16364|uniprotkb:Q6UBD1|uniprotkb:Q9UMA3|intact:EBI-2614650|uniprotkb:Q59FF2|uniprotkb:Q9UD94|uniprotkb:E9PQG7|uniprotkb:Q9HBJ3 intact:EBI-1801917 psi-mi:kmt2a_human(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym) psi-mi:hoxa9_human_gene(display_short)|psi-mi:ENSG00000078399(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Paggetti et al. (2010) imex:IM-15115|pubmed:20581860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1262"(I2D) intact:EBI-2927253|imex:IM-15115-20 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) go:"GO:2000615"(regulation of histone H3-K9 acetylation)|interpro:IPR001214(SET)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|interpro:IPR036427|interpro:IPR037927|interpro:IPR041958|interpro:IPR042023|interpro:IPR042025|interpro:IPR044133|mint:Q03164|rcsb pdb:2AGH|rcsb pdb:2J2S|rcsb pdb:2JYI|rcsb pdb:2KKF|rcsb pdb:2KU7|rcsb pdb:2KYU|rcsb pdb:2LXS|rcsb pdb:2LXT|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2W5Y|ensembl:ENSG00000118058(gene)|ensembl:ENST00000389506(transcript)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071440"(regulation of histone H3-K14 acetylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|go:"GO:1905642"(negative regulation of DNA methylation)|refseq:NP_001184033.1|refseq:NP_005924.2|ensembl:ENSP00000374157|ensembl:ENST00000534358|ensembl:ENSP00000436786|ensembl:ENST00000649699|ensembl:ENSP00000496927|dip:DIP-29221N|rcsb pdb:2W5Z|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3LQH|rcsb pdb:3LQI|rcsb pdb:3LQJ|rcsb pdb:3P4F|rcsb pdb:3U85|rcsb pdb:3U88|rcsb pdb:4ESG|rcsb pdb:4GQ6|rcsb pdb:4NW3|rcsb pdb:5F5E|rcsb pdb:5F6L|rcsb pdb:5SVH|rcsb pdb:6EMQ|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U9K|rcsb pdb:6U9M|rcsb pdb:6U9N|rcsb pdb:6U9R|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|reactome:R-HSA-3214841|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9616222 - - - - figure legend:Fig. 3b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2010/09/14 2014/10/16 rogid:r9J9pjnLZI7GCBSHYqnmzjv9WvM9606 - intact-crc:79A5228272E6590C false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q92794 ensembl:ENSG00000106004 intact:EBI-948013|intact:EBI-1048839|uniprotkb:Q76L81|ensembl:ENSP00000265713|ensembl:ENSP00000380136 intact:EBI-2927244 psi-mi:kat6a_human(display_long)|uniprotkb:KAT6A(gene name)|psi-mi:KAT6A(display_short)|uniprotkb:MOZ(gene name synonym)|uniprotkb:RUNXBP2(gene name synonym)|uniprotkb:ZNF220(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3(gene name synonym)|uniprotkb:Runt-related transcription factor-binding protein 2(gene name synonym)|uniprotkb:Monocytic leukemia zinc finger protein(gene name synonym)|uniprotkb:Zinc finger protein 220(gene name synonym)|uniprotkb:MYST3(gene name synonym) psi-mi:hoxa5_human_gene(display_short)|psi-mi:ENSG00000106004(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Paggetti et al. (2010) imex:IM-15115|pubmed:20581860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1262"(I2D) intact:EBI-2935258|imex:IM-15115-24 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) refseq:NP_006757.2|ensembl:ENSP00000265713|ensembl:ENSP00000380136|refseq:XP_016869352.1|refseq:XP_016869353.1|ensembl:ENSG00000083168(gene)|ensembl:ENST00000265713(transcript)|ensembl:ENST00000396930(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006323"(DNA packaging)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070776"(MOZ/MORF histone acetyltransferase complex)|go:"GO:0090398"(cellular senescence)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR005818(Histone H1/H5)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR019787|interpro:IPR031280|interpro:IPR036388|interpro:IPR036390|interpro:IPR040706|mint:Q92794|rcsb pdb:1M36|rcsb pdb:2LN0|rcsb pdb:2OZU|rcsb pdb:2RC4|rcsb pdb:3V43|rcsb pdb:4LJN|rcsb pdb:4LK9|rcsb pdb:4LKA|rcsb pdb:4LLB|rcsb pdb:5B75|rcsb pdb:5B76|rcsb pdb:5B77|rcsb pdb:5B78|rcsb pdb:6LSB|reactome:R-HSA-3214847|reactome:R-HSA-6804758 - - - - figure legend:Fig. 3b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2010/09/14 2014/10/16 rogid:jPgi03a1G13Lv1IjZOz9vz1FvcY9606 - intact-crc:7E0B1641D438C470 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q92794 ensembl:ENSG00000122592 intact:EBI-948013|intact:EBI-1048839|uniprotkb:Q76L81|ensembl:ENSP00000265713|ensembl:ENSP00000380136 intact:EBI-1801907 psi-mi:kat6a_human(display_long)|uniprotkb:KAT6A(gene name)|psi-mi:KAT6A(display_short)|uniprotkb:MOZ(gene name synonym)|uniprotkb:RUNXBP2(gene name synonym)|uniprotkb:ZNF220(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3(gene name synonym)|uniprotkb:Runt-related transcription factor-binding protein 2(gene name synonym)|uniprotkb:Monocytic leukemia zinc finger protein(gene name synonym)|uniprotkb:Zinc finger protein 220(gene name synonym)|uniprotkb:MYST3(gene name synonym) psi-mi:hoxa7_human_gene(display_short)|psi-mi:ENSG00000122592(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Paggetti et al. (2010) imex:IM-15115|pubmed:20581860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1262"(I2D) intact:EBI-2935263|imex:IM-15115-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) refseq:NP_006757.2|ensembl:ENSP00000265713|ensembl:ENSP00000380136|refseq:XP_016869352.1|refseq:XP_016869353.1|ensembl:ENSG00000083168(gene)|ensembl:ENST00000265713(transcript)|ensembl:ENST00000396930(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006323"(DNA packaging)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070776"(MOZ/MORF histone acetyltransferase complex)|go:"GO:0090398"(cellular senescence)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR005818(Histone H1/H5)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR019787|interpro:IPR031280|interpro:IPR036388|interpro:IPR036390|interpro:IPR040706|mint:Q92794|rcsb pdb:1M36|rcsb pdb:2LN0|rcsb pdb:2OZU|rcsb pdb:2RC4|rcsb pdb:3V43|rcsb pdb:4LJN|rcsb pdb:4LK9|rcsb pdb:4LKA|rcsb pdb:4LLB|rcsb pdb:5B75|rcsb pdb:5B76|rcsb pdb:5B77|rcsb pdb:5B78|rcsb pdb:6LSB|reactome:R-HSA-3214847|reactome:R-HSA-6804758 - - - - figure legend:Fig. 3b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2010/09/14 2014/10/16 rogid:jPgi03a1G13Lv1IjZOz9vz1FvcY9606 - intact-crc:2C39C936BAAB7B16 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) ensembl:ENSG00000078399 uniprotkb:Q92794 intact:EBI-1801917 intact:EBI-948013|intact:EBI-1048839|uniprotkb:Q76L81|ensembl:ENSP00000265713|ensembl:ENSP00000380136 psi-mi:hoxa9_human_gene(display_short)|psi-mi:ENSG00000078399(display_long) psi-mi:kat6a_human(display_long)|uniprotkb:KAT6A(gene name)|psi-mi:KAT6A(display_short)|uniprotkb:MOZ(gene name synonym)|uniprotkb:RUNXBP2(gene name synonym)|uniprotkb:ZNF220(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3(gene name synonym)|uniprotkb:Runt-related transcription factor-binding protein 2(gene name synonym)|uniprotkb:Monocytic leukemia zinc finger protein(gene name synonym)|uniprotkb:Zinc finger protein 220(gene name synonym)|uniprotkb:MYST3(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Paggetti et al. (2010) imex:IM-15115|pubmed:20581860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1262"(I2D) intact:EBI-2935268|imex:IM-15115-26 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0250"(gene) psi-mi:"MI:0326"(protein) - refseq:NP_006757.2|ensembl:ENSP00000265713|ensembl:ENSP00000380136|refseq:XP_016869352.1|refseq:XP_016869353.1|ensembl:ENSG00000083168(gene)|ensembl:ENST00000265713(transcript)|ensembl:ENST00000396930(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006323"(DNA packaging)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070776"(MOZ/MORF histone acetyltransferase complex)|go:"GO:0090398"(cellular senescence)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR005818(Histone H1/H5)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR019787|interpro:IPR031280|interpro:IPR036388|interpro:IPR036390|interpro:IPR040706|mint:Q92794|rcsb pdb:1M36|rcsb pdb:2LN0|rcsb pdb:2OZU|rcsb pdb:2RC4|rcsb pdb:3V43|rcsb pdb:4LJN|rcsb pdb:4LK9|rcsb pdb:4LKA|rcsb pdb:4LLB|rcsb pdb:5B75|rcsb pdb:5B76|rcsb pdb:5B77|rcsb pdb:5B78|rcsb pdb:6LSB|reactome:R-HSA-3214847|reactome:R-HSA-6804758 - - - figure legend:Fig. 3b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2010/09/14 2014/10/16 - rogid:jPgi03a1G13Lv1IjZOz9vz1FvcY9606 intact-crc:0AFB68EA335F7CC6 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q03164 ensembl:ENSG00000106004 intact:EBI-591370|ensembl:ENSP00000374157|uniprotkb:Q13743|uniprotkb:Q13744|uniprotkb:Q14845|uniprotkb:Q16364|uniprotkb:Q6UBD1|uniprotkb:Q9UMA3|intact:EBI-2614650|uniprotkb:Q59FF2|uniprotkb:Q9UD94|uniprotkb:E9PQG7|uniprotkb:Q9HBJ3 intact:EBI-2927244 psi-mi:kmt2a_human(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym) psi-mi:hoxa5_human_gene(display_short)|psi-mi:ENSG00000106004(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Paggetti et al. (2010) imex:IM-15115|pubmed:20581860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1262"(I2D) intact:EBI-2930760|imex:IM-15115-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) go:"GO:2000615"(regulation of histone H3-K9 acetylation)|interpro:IPR001214(SET)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|interpro:IPR036427|interpro:IPR037927|interpro:IPR041958|interpro:IPR042023|interpro:IPR042025|interpro:IPR044133|mint:Q03164|rcsb pdb:2AGH|rcsb pdb:2J2S|rcsb pdb:2JYI|rcsb pdb:2KKF|rcsb pdb:2KU7|rcsb pdb:2KYU|rcsb pdb:2LXS|rcsb pdb:2LXT|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2W5Y|ensembl:ENSG00000118058(gene)|ensembl:ENST00000389506(transcript)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071440"(regulation of histone H3-K14 acetylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|go:"GO:1905642"(negative regulation of DNA methylation)|refseq:NP_001184033.1|refseq:NP_005924.2|ensembl:ENSP00000374157|ensembl:ENST00000534358|ensembl:ENSP00000436786|ensembl:ENST00000649699|ensembl:ENSP00000496927|dip:DIP-29221N|rcsb pdb:2W5Z|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3LQH|rcsb pdb:3LQI|rcsb pdb:3LQJ|rcsb pdb:3P4F|rcsb pdb:3U85|rcsb pdb:3U88|rcsb pdb:4ESG|rcsb pdb:4GQ6|rcsb pdb:4NW3|rcsb pdb:5F5E|rcsb pdb:5F6L|rcsb pdb:5SVH|rcsb pdb:6EMQ|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U9K|rcsb pdb:6U9M|rcsb pdb:6U9N|rcsb pdb:6U9R|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|reactome:R-HSA-3214841|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9616222 - - - - figure legend:Fig. 3c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-pbmc)|taxid:9606(Human Peripheral Blood Mononuclear cell) - 2010/09/14 2014/10/16 rogid:r9J9pjnLZI7GCBSHYqnmzjv9WvM9606 - intact-crc:D1AD71E43695CCC0 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q03164 ensembl:ENSG00000122592 intact:EBI-591370|ensembl:ENSP00000374157|uniprotkb:Q13743|uniprotkb:Q13744|uniprotkb:Q14845|uniprotkb:Q16364|uniprotkb:Q6UBD1|uniprotkb:Q9UMA3|intact:EBI-2614650|uniprotkb:Q59FF2|uniprotkb:Q9UD94|uniprotkb:E9PQG7|uniprotkb:Q9HBJ3 intact:EBI-1801907 psi-mi:kmt2a_human(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym) psi-mi:hoxa7_human_gene(display_short)|psi-mi:ENSG00000122592(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Paggetti et al. (2010) imex:IM-15115|pubmed:20581860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1262"(I2D) intact:EBI-2930765|imex:IM-15115-22 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) go:"GO:2000615"(regulation of histone H3-K9 acetylation)|interpro:IPR001214(SET)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|interpro:IPR036427|interpro:IPR037927|interpro:IPR041958|interpro:IPR042023|interpro:IPR042025|interpro:IPR044133|mint:Q03164|rcsb pdb:2AGH|rcsb pdb:2J2S|rcsb pdb:2JYI|rcsb pdb:2KKF|rcsb pdb:2KU7|rcsb pdb:2KYU|rcsb pdb:2LXS|rcsb pdb:2LXT|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2W5Y|ensembl:ENSG00000118058(gene)|ensembl:ENST00000389506(transcript)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071440"(regulation of histone H3-K14 acetylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|go:"GO:1905642"(negative regulation of DNA methylation)|refseq:NP_001184033.1|refseq:NP_005924.2|ensembl:ENSP00000374157|ensembl:ENST00000534358|ensembl:ENSP00000436786|ensembl:ENST00000649699|ensembl:ENSP00000496927|dip:DIP-29221N|rcsb pdb:2W5Z|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3LQH|rcsb pdb:3LQI|rcsb pdb:3LQJ|rcsb pdb:3P4F|rcsb pdb:3U85|rcsb pdb:3U88|rcsb pdb:4ESG|rcsb pdb:4GQ6|rcsb pdb:4NW3|rcsb pdb:5F5E|rcsb pdb:5F6L|rcsb pdb:5SVH|rcsb pdb:6EMQ|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U9K|rcsb pdb:6U9M|rcsb pdb:6U9N|rcsb pdb:6U9R|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|reactome:R-HSA-3214841|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9616222 - - - - figure legend:Fig. 3c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-pbmc)|taxid:9606(Human Peripheral Blood Mononuclear cell) - 2010/09/14 2014/10/16 rogid:r9J9pjnLZI7GCBSHYqnmzjv9WvM9606 - intact-crc:5C589716529B3F63 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q03164 ensembl:ENSG00000078399 intact:EBI-591370|ensembl:ENSP00000374157|uniprotkb:Q13743|uniprotkb:Q13744|uniprotkb:Q14845|uniprotkb:Q16364|uniprotkb:Q6UBD1|uniprotkb:Q9UMA3|intact:EBI-2614650|uniprotkb:Q59FF2|uniprotkb:Q9UD94|uniprotkb:E9PQG7|uniprotkb:Q9HBJ3 intact:EBI-1801917 psi-mi:kmt2a_human(display_long)|uniprotkb:KMT2A(gene name)|psi-mi:KMT2A(display_short)|uniprotkb:ALL-1(gene name synonym)|uniprotkb:ALL1(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 7(gene name synonym)|uniprotkb:CXXC7(gene name synonym)|uniprotkb:HRX(gene name synonym)|uniprotkb:HTRX(gene name synonym)|uniprotkb:MLL(gene name synonym)|uniprotkb:MLL1(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 1(gene name synonym)|uniprotkb:TRX1(gene name synonym)|uniprotkb:Trithorax-like protein(gene name synonym)|uniprotkb:Zinc finger protein HRX(gene name synonym)|uniprotkb:Cysteine methyltransferase KMT2A(gene name synonym) psi-mi:hoxa9_human_gene(display_short)|psi-mi:ENSG00000078399(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Paggetti et al. (2010) imex:IM-15115|pubmed:20581860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1262"(I2D) intact:EBI-2930770|imex:IM-15115-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) go:"GO:2000615"(regulation of histone H3-K9 acetylation)|interpro:IPR001214(SET)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR003888(FY-rich, N-terminal)|interpro:IPR003889(FY-rich, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016569(Methyltransferase, trithorax)|interpro:IPR019787|interpro:IPR034732|interpro:IPR036427|interpro:IPR037927|interpro:IPR041958|interpro:IPR042023|interpro:IPR042025|interpro:IPR044133|mint:Q03164|rcsb pdb:2AGH|rcsb pdb:2J2S|rcsb pdb:2JYI|rcsb pdb:2KKF|rcsb pdb:2KU7|rcsb pdb:2KYU|rcsb pdb:2LXS|rcsb pdb:2LXT|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2W5Y|ensembl:ENSG00000118058(gene)|ensembl:ENST00000389506(transcript)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044648"(histone H3-K4 dimethylation)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071440"(regulation of histone H3-K14 acetylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097692"(histone H3-K4 monomethylation)|go:"GO:0106363"(protein-cysteine methyltransferase activity)|go:"GO:1905642"(negative regulation of DNA methylation)|refseq:NP_001184033.1|refseq:NP_005924.2|ensembl:ENSP00000374157|ensembl:ENST00000534358|ensembl:ENSP00000436786|ensembl:ENST00000649699|ensembl:ENSP00000496927|dip:DIP-29221N|rcsb pdb:2W5Z|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3LQH|rcsb pdb:3LQI|rcsb pdb:3LQJ|rcsb pdb:3P4F|rcsb pdb:3U85|rcsb pdb:3U88|rcsb pdb:4ESG|rcsb pdb:4GQ6|rcsb pdb:4NW3|rcsb pdb:5F5E|rcsb pdb:5F6L|rcsb pdb:5SVH|rcsb pdb:6EMQ|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U9K|rcsb pdb:6U9M|rcsb pdb:6U9N|rcsb pdb:6U9R|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|reactome:R-HSA-3214841|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9616222 - - - - figure legend:Fig. 3c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-pbmc)|taxid:9606(Human Peripheral Blood Mononuclear cell) - 2010/09/14 2014/10/16 rogid:r9J9pjnLZI7GCBSHYqnmzjv9WvM9606 - intact-crc:0C56D1B191B0DD32 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q92794 ensembl:ENSG00000106004 intact:EBI-948013|intact:EBI-1048839|uniprotkb:Q76L81|ensembl:ENSP00000265713|ensembl:ENSP00000380136 intact:EBI-2927244 psi-mi:kat6a_human(display_long)|uniprotkb:KAT6A(gene name)|psi-mi:KAT6A(display_short)|uniprotkb:MOZ(gene name synonym)|uniprotkb:RUNXBP2(gene name synonym)|uniprotkb:ZNF220(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3(gene name synonym)|uniprotkb:Runt-related transcription factor-binding protein 2(gene name synonym)|uniprotkb:Monocytic leukemia zinc finger protein(gene name synonym)|uniprotkb:Zinc finger protein 220(gene name synonym)|uniprotkb:MYST3(gene name synonym) psi-mi:hoxa5_human_gene(display_short)|psi-mi:ENSG00000106004(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Paggetti et al. (2010) imex:IM-15115|pubmed:20581860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1262"(I2D) intact:EBI-2935273|imex:IM-15115-27 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) refseq:NP_006757.2|ensembl:ENSP00000265713|ensembl:ENSP00000380136|refseq:XP_016869352.1|refseq:XP_016869353.1|ensembl:ENSG00000083168(gene)|ensembl:ENST00000265713(transcript)|ensembl:ENST00000396930(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006323"(DNA packaging)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070776"(MOZ/MORF histone acetyltransferase complex)|go:"GO:0090398"(cellular senescence)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR005818(Histone H1/H5)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR019787|interpro:IPR031280|interpro:IPR036388|interpro:IPR036390|interpro:IPR040706|mint:Q92794|rcsb pdb:1M36|rcsb pdb:2LN0|rcsb pdb:2OZU|rcsb pdb:2RC4|rcsb pdb:3V43|rcsb pdb:4LJN|rcsb pdb:4LK9|rcsb pdb:4LKA|rcsb pdb:4LLB|rcsb pdb:5B75|rcsb pdb:5B76|rcsb pdb:5B77|rcsb pdb:5B78|rcsb pdb:6LSB|reactome:R-HSA-3214847|reactome:R-HSA-6804758 - - - - figure legend:Fig. 3c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-pbmc)|taxid:9606(Human Peripheral Blood Mononuclear cell) - 2010/09/14 2014/10/16 rogid:jPgi03a1G13Lv1IjZOz9vz1FvcY9606 - intact-crc:923330B1948BEAD1 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q92794 ensembl:ENSG00000122592 intact:EBI-948013|intact:EBI-1048839|uniprotkb:Q76L81|ensembl:ENSP00000265713|ensembl:ENSP00000380136 intact:EBI-1801907 psi-mi:kat6a_human(display_long)|uniprotkb:KAT6A(gene name)|psi-mi:KAT6A(display_short)|uniprotkb:MOZ(gene name synonym)|uniprotkb:RUNXBP2(gene name synonym)|uniprotkb:ZNF220(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3(gene name synonym)|uniprotkb:Runt-related transcription factor-binding protein 2(gene name synonym)|uniprotkb:Monocytic leukemia zinc finger protein(gene name synonym)|uniprotkb:Zinc finger protein 220(gene name synonym)|uniprotkb:MYST3(gene name synonym) psi-mi:hoxa7_human_gene(display_short)|psi-mi:ENSG00000122592(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Paggetti et al. (2010) imex:IM-15115|pubmed:20581860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1262"(I2D) intact:EBI-2935278|imex:IM-15115-28 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) refseq:NP_006757.2|ensembl:ENSP00000265713|ensembl:ENSP00000380136|refseq:XP_016869352.1|refseq:XP_016869353.1|ensembl:ENSG00000083168(gene)|ensembl:ENST00000265713(transcript)|ensembl:ENST00000396930(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006323"(DNA packaging)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070776"(MOZ/MORF histone acetyltransferase complex)|go:"GO:0090398"(cellular senescence)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR005818(Histone H1/H5)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR019787|interpro:IPR031280|interpro:IPR036388|interpro:IPR036390|interpro:IPR040706|mint:Q92794|rcsb pdb:1M36|rcsb pdb:2LN0|rcsb pdb:2OZU|rcsb pdb:2RC4|rcsb pdb:3V43|rcsb pdb:4LJN|rcsb pdb:4LK9|rcsb pdb:4LKA|rcsb pdb:4LLB|rcsb pdb:5B75|rcsb pdb:5B76|rcsb pdb:5B77|rcsb pdb:5B78|rcsb pdb:6LSB|reactome:R-HSA-3214847|reactome:R-HSA-6804758 - - - - figure legend:Fig. 3c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-pbmc)|taxid:9606(Human Peripheral Blood Mononuclear cell) - 2010/09/14 2014/10/16 rogid:jPgi03a1G13Lv1IjZOz9vz1FvcY9606 - intact-crc:1FC6D643F0851972 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q92794 ensembl:ENSG00000078399 intact:EBI-948013|intact:EBI-1048839|uniprotkb:Q76L81|ensembl:ENSP00000265713|ensembl:ENSP00000380136 intact:EBI-1801917 psi-mi:kat6a_human(display_long)|uniprotkb:KAT6A(gene name)|psi-mi:KAT6A(display_short)|uniprotkb:MOZ(gene name synonym)|uniprotkb:RUNXBP2(gene name synonym)|uniprotkb:ZNF220(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3(gene name synonym)|uniprotkb:Runt-related transcription factor-binding protein 2(gene name synonym)|uniprotkb:Monocytic leukemia zinc finger protein(gene name synonym)|uniprotkb:Zinc finger protein 220(gene name synonym)|uniprotkb:MYST3(gene name synonym) psi-mi:hoxa9_human_gene(display_short)|psi-mi:ENSG00000078399(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Paggetti et al. (2010) imex:IM-15115|pubmed:20581860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1262"(I2D) intact:EBI-2935283|imex:IM-15115-29 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) refseq:NP_006757.2|ensembl:ENSP00000265713|ensembl:ENSP00000380136|refseq:XP_016869352.1|refseq:XP_016869353.1|ensembl:ENSG00000083168(gene)|ensembl:ENST00000265713(transcript)|ensembl:ENST00000396930(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006323"(DNA packaging)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070776"(MOZ/MORF histone acetyltransferase complex)|go:"GO:0090398"(cellular senescence)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR005818(Histone H1/H5)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR019787|interpro:IPR031280|interpro:IPR036388|interpro:IPR036390|interpro:IPR040706|mint:Q92794|rcsb pdb:1M36|rcsb pdb:2LN0|rcsb pdb:2OZU|rcsb pdb:2RC4|rcsb pdb:3V43|rcsb pdb:4LJN|rcsb pdb:4LK9|rcsb pdb:4LKA|rcsb pdb:4LLB|rcsb pdb:5B75|rcsb pdb:5B76|rcsb pdb:5B77|rcsb pdb:5B78|rcsb pdb:6LSB|reactome:R-HSA-3214847|reactome:R-HSA-6804758 - - - - figure legend:Fig. 3c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-pbmc)|taxid:9606(Human Peripheral Blood Mononuclear cell) - 2010/09/14 2014/10/16 rogid:jPgi03a1G13Lv1IjZOz9vz1FvcY9606 - intact-crc:4FC890E433AEFB23 false - - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr)