#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q63373-3 uniprotkb:Q8N0W4 intact:EBI-20994045 intact:EBI-2862707|uniprotkb:Q9ULG0|uniprotkb:Q6UX10|ensembl:ENSP00000275857|ensembl:ENSP00000370482|ensembl:ENSP00000370483|ensembl:ENSP00000370485 psi-mi:q63373-3(display_long)|uniprotkb:Neurexin I-beta(gene name synonym)|uniprotkb:Beta-4B5A(isoform synonym)|uniprotkb:Nrxn1(gene name)|psi-mi:Nrxn1(display_short) psi-mi:nlgnx_human(display_long)|uniprotkb:NLGN4X(gene name)|psi-mi:NLGN4X(display_short)|uniprotkb:KIAA1260(gene name synonym)|uniprotkb:NLGN4(gene name synonym)|uniprotkb:HNLX(gene name synonym)|uniprotkb:UNQ365/PRO701(orf name) psi-mi:"MI:0114"(x-ray crystallography) Leone et al. (2010) pubmed:20543817|imex:IM-15017|mint:MINT-7988457|doi:10.1038/emboj.2010.123 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8017482|mint:MINT-7988463|imex:IM-15017-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1780696(isoform-parent)|mint:MINT-7988466(identity) refseq:XP_011543849.1|refseq:XP_011543850.1|refseq:XP_006724567.1|refseq:XP_016885179.1|refseq:XP_016885180.1|refseq:XP_016885181.1|refseq:XP_016885182.1|refseq:NP_065793.1|refseq:NP_851849.1|refseq:NP_001269074.1|refseq:NP_001269075.1|refseq:XP_005274621.1|refseq:XP_005274622.1|refseq:XP_005274623.1|go:"GO:0098985"(asymmetric, glutamatergic, excitatory synapse)|go:"GO:0099054"(presynapse assembly)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030025|rcsb pdb:2WQZ|rcsb pdb:2XB6|rcsb pdb:3BE8|reactome:R-HSA-6794361|ensembl:ENSG00000146938(gene)|ensembl:ENST00000275857(transcript)|ensembl:ENST00000381092(transcript)|ensembl:ENST00000381093(transcript)|ensembl:ENST00000381095(transcript)|go:"GO:0003360"(brainstem development)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0021549"(cerebellum development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0031404"(chloride ion binding)|go:"GO:0035176"(social behavior)|go:"GO:0035265"(organ growth)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045202"(synapse)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060076"(excitatory synapse)|go:"GO:0071625"(vocalization behavior)|go:"GO:0089717"(spanning component of membrane)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098793"(presynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098983"(symmetric, GABA-ergic, inhibitory synapse)|mint:MINT-7988465(identity) - comment:"Stoichiometry: 1.2" comment:"Stoichiometry: 2.1" comment:mint|figure legend:f1 t1 t2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/08/03 2022/01/21 rogid:voabMMncKJwjAiQ4kdUcGukdtUw10116 rogid:7PtRrX28usbCkTHxS8QfWEgDEn49606 intact-crc:880CD431E0EA7115|rigid:GYDCp0waGqOmIPmT7kDMdCuueu4 false binding-associated region:81-258(MINT-7988469) binding-associated region:44-619(MINT-7988473) 1 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q63373-3 uniprotkb:Q8N0W4 intact:EBI-20994045 intact:EBI-2862707|uniprotkb:Q9ULG0|uniprotkb:Q6UX10|ensembl:ENSP00000275857|ensembl:ENSP00000370482|ensembl:ENSP00000370483|ensembl:ENSP00000370485 psi-mi:q63373-3(display_long)|uniprotkb:Neurexin I-beta(gene name synonym)|uniprotkb:Beta-4B5A(isoform synonym)|uniprotkb:Nrxn1(gene name)|psi-mi:Nrxn1(display_short) psi-mi:nlgnx_human(display_long)|uniprotkb:NLGN4X(gene name)|psi-mi:NLGN4X(display_short)|uniprotkb:KIAA1260(gene name synonym)|uniprotkb:NLGN4(gene name synonym)|uniprotkb:HNLX(gene name synonym)|uniprotkb:UNQ365/PRO701(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Leone et al. (2010) pubmed:20543817|imex:IM-15017|mint:MINT-7988457|doi:10.1038/emboj.2010.123 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8017527|mint:MINT-7988481|imex:IM-15017-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1780696(isoform-parent)|mint:MINT-7988487(identity) refseq:XP_011543849.1|refseq:XP_011543850.1|refseq:XP_006724567.1|refseq:XP_016885179.1|refseq:XP_016885180.1|refseq:XP_016885181.1|refseq:XP_016885182.1|refseq:NP_065793.1|refseq:NP_851849.1|refseq:NP_001269074.1|refseq:NP_001269075.1|refseq:XP_005274621.1|refseq:XP_005274622.1|refseq:XP_005274623.1|go:"GO:0098985"(asymmetric, glutamatergic, excitatory synapse)|go:"GO:0099054"(presynapse assembly)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030025|rcsb pdb:2WQZ|rcsb pdb:2XB6|rcsb pdb:3BE8|reactome:R-HSA-6794361|ensembl:ENSG00000146938(gene)|ensembl:ENST00000275857(transcript)|ensembl:ENST00000381092(transcript)|ensembl:ENST00000381093(transcript)|ensembl:ENST00000381095(transcript)|go:"GO:0003360"(brainstem development)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0021549"(cerebellum development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0031404"(chloride ion binding)|go:"GO:0035176"(social behavior)|go:"GO:0035265"(organ growth)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045202"(synapse)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060076"(excitatory synapse)|go:"GO:0071625"(vocalization behavior)|go:"GO:0089717"(spanning component of membrane)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098793"(presynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098983"(symmetric, GABA-ergic, inhibitory synapse)|mint:MINT-7988483(identity) - - - comment:mint|figure legend:f3b f3d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.15x10^-7(molar) 2010/08/03 2018/12/03 rogid:voabMMncKJwjAiQ4kdUcGukdtUw10116 rogid:7PtRrX28usbCkTHxS8QfWEgDEn49606 intact-crc:AE064409241CB069|rigid:GYDCp0waGqOmIPmT7kDMdCuueu4 false mutation disrupting interaction:109-109(MINT-7988496)|binding-associated region:81-258(MINT-7988488) binding-associated region:44-619(MINT-7988484) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N0W4 uniprotkb:Q63373-3 intact:EBI-2862707|uniprotkb:Q9ULG0|uniprotkb:Q6UX10|ensembl:ENSP00000275857|ensembl:ENSP00000370482|ensembl:ENSP00000370483|ensembl:ENSP00000370485 intact:EBI-20994045 psi-mi:nlgnx_human(display_long)|uniprotkb:NLGN4X(gene name)|psi-mi:NLGN4X(display_short)|uniprotkb:KIAA1260(gene name synonym)|uniprotkb:NLGN4(gene name synonym)|uniprotkb:HNLX(gene name synonym)|uniprotkb:UNQ365/PRO701(orf name) psi-mi:q63373-3(display_long)|uniprotkb:Neurexin I-beta(gene name synonym)|uniprotkb:Beta-4B5A(isoform synonym)|uniprotkb:Nrxn1(gene name)|psi-mi:Nrxn1(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Leone et al. (2010) pubmed:20543817|imex:IM-15017|mint:MINT-7988457|doi:10.1038/emboj.2010.123 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8017628|mint:MINT-7988518|imex:IM-15017-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011543849.1|refseq:XP_011543850.1|refseq:XP_006724567.1|refseq:XP_016885179.1|refseq:XP_016885180.1|refseq:XP_016885181.1|refseq:XP_016885182.1|refseq:NP_065793.1|refseq:NP_851849.1|refseq:NP_001269074.1|refseq:NP_001269075.1|refseq:XP_005274621.1|refseq:XP_005274622.1|refseq:XP_005274623.1|go:"GO:0098985"(asymmetric, glutamatergic, excitatory synapse)|go:"GO:0099054"(presynapse assembly)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030025|rcsb pdb:2WQZ|rcsb pdb:2XB6|rcsb pdb:3BE8|reactome:R-HSA-6794361|ensembl:ENSG00000146938(gene)|ensembl:ENST00000275857(transcript)|ensembl:ENST00000381092(transcript)|ensembl:ENST00000381093(transcript)|ensembl:ENST00000381095(transcript)|go:"GO:0003360"(brainstem development)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0021549"(cerebellum development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0031404"(chloride ion binding)|go:"GO:0035176"(social behavior)|go:"GO:0035265"(organ growth)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045202"(synapse)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060076"(excitatory synapse)|go:"GO:0071625"(vocalization behavior)|go:"GO:0089717"(spanning component of membrane)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098793"(presynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098983"(symmetric, GABA-ergic, inhibitory synapse)|mint:MINT-7988521(identity) intact:EBI-1780696(isoform-parent)|mint:MINT-7988525(identity) - - - comment:mint|figure legend:f3b f3d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.15x10^-7(molar) 2010/08/03 2018/12/03 rogid:7PtRrX28usbCkTHxS8QfWEgDEn49606 rogid:voabMMncKJwjAiQ4kdUcGukdtUw10116 intact-crc:AB4C67E48E678FB7|rigid:GYDCp0waGqOmIPmT7kDMdCuueu4 false binding-associated region:44-619(MINT-7988522) binding-associated region:81-258(MINT-7988526)|mutation disrupting interaction:206-206(MINT-7988528) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q63373-3 uniprotkb:Q8N0W4 intact:EBI-20994045 intact:EBI-2862707|uniprotkb:Q9ULG0|uniprotkb:Q6UX10|ensembl:ENSP00000275857|ensembl:ENSP00000370482|ensembl:ENSP00000370483|ensembl:ENSP00000370485 psi-mi:q63373-3(display_long)|uniprotkb:Neurexin I-beta(gene name synonym)|uniprotkb:Beta-4B5A(isoform synonym)|uniprotkb:Nrxn1(gene name)|psi-mi:Nrxn1(display_short) psi-mi:nlgnx_human(display_long)|uniprotkb:NLGN4X(gene name)|psi-mi:NLGN4X(display_short)|uniprotkb:KIAA1260(gene name synonym)|uniprotkb:NLGN4(gene name synonym)|uniprotkb:HNLX(gene name synonym)|uniprotkb:UNQ365/PRO701(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Leone et al. (2010) pubmed:20543817|imex:IM-15017|mint:MINT-7988457|doi:10.1038/emboj.2010.123 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8017573|mint:MINT-7988502|imex:IM-15017-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1780696(isoform-parent)|mint:MINT-7988505(identity) refseq:XP_011543849.1|refseq:XP_011543850.1|refseq:XP_006724567.1|refseq:XP_016885179.1|refseq:XP_016885180.1|refseq:XP_016885181.1|refseq:XP_016885182.1|refseq:NP_065793.1|refseq:NP_851849.1|refseq:NP_001269074.1|refseq:NP_001269075.1|refseq:XP_005274621.1|refseq:XP_005274622.1|refseq:XP_005274623.1|go:"GO:0098985"(asymmetric, glutamatergic, excitatory synapse)|go:"GO:0099054"(presynapse assembly)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030025|rcsb pdb:2WQZ|rcsb pdb:2XB6|rcsb pdb:3BE8|reactome:R-HSA-6794361|ensembl:ENSG00000146938(gene)|ensembl:ENST00000275857(transcript)|ensembl:ENST00000381092(transcript)|ensembl:ENST00000381093(transcript)|ensembl:ENST00000381095(transcript)|go:"GO:0003360"(brainstem development)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0021549"(cerebellum development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0031404"(chloride ion binding)|go:"GO:0035176"(social behavior)|go:"GO:0035265"(organ growth)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045202"(synapse)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060076"(excitatory synapse)|go:"GO:0071625"(vocalization behavior)|go:"GO:0089717"(spanning component of membrane)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098793"(presynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098983"(symmetric, GABA-ergic, inhibitory synapse)|mint:MINT-7988511(identity) - - - comment:mint|figure legend:f3b f3d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.15x10^-7(molar) 2010/08/03 2018/12/03 rogid:voabMMncKJwjAiQ4kdUcGukdtUw10116 rogid:7PtRrX28usbCkTHxS8QfWEgDEn49606 intact-crc:489B885F18E5655D|rigid:GYDCp0waGqOmIPmT7kDMdCuueu4 false mutation disrupting interaction:202-202(MINT-7988506)|binding-associated region:81-258(MINT-7988508) binding-associated region:44-619(MINT-7988512) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q63373-3 uniprotkb:Q62765-2 intact:EBI-20994045 intact:EBI-20994039 psi-mi:q63373-3(display_long)|uniprotkb:Neurexin I-beta(gene name synonym)|uniprotkb:Beta-4B5A(isoform synonym)|uniprotkb:Nrxn1(gene name)|psi-mi:Nrxn1(display_short) psi-mi:q62765-2(display_long)|uniprotkb:Neuroligin I(gene name synonym)|uniprotkb:Nlgn1(gene name)|psi-mi:Nlgn1(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Leone et al. (2010) pubmed:20543817|imex:IM-15017|mint:MINT-7988457|doi:10.1038/emboj.2010.123 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8017700|mint:MINT-7988550|imex:IM-15017-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1780696(isoform-parent)|mint:MINT-7988557(identity) intact:EBI-7281118(isoform-parent)|mint:MINT-7988553(identity) - - isoform-comment:No experimental confirmation available. figure legend:f3a f3c|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:4.0x10^-8(molar) 2010/08/03 2018/12/03 rogid:voabMMncKJwjAiQ4kdUcGukdtUw10116 rogid:Nmx72I+D36c9ZpLnzKKLVBvaM8g10116 intact-crc:3BCE19C9FBCACE50|rigid:4joCliOiSCLMgLVUzvVK6S1es6Y false binding-associated region:81-258(MINT-7988560)|mutation decreasing interaction:103-103(MINT-7988558) binding-associated region:46-609(MINT-7988554) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q63373-3 uniprotkb:Q8N0W4 intact:EBI-20994045 intact:EBI-2862707|uniprotkb:Q9ULG0|uniprotkb:Q6UX10|ensembl:ENSP00000275857|ensembl:ENSP00000370482|ensembl:ENSP00000370483|ensembl:ENSP00000370485 psi-mi:q63373-3(display_long)|uniprotkb:Neurexin I-beta(gene name synonym)|uniprotkb:Beta-4B5A(isoform synonym)|uniprotkb:Nrxn1(gene name)|psi-mi:Nrxn1(display_short) psi-mi:nlgnx_human(display_long)|uniprotkb:NLGN4X(gene name)|psi-mi:NLGN4X(display_short)|uniprotkb:KIAA1260(gene name synonym)|uniprotkb:NLGN4(gene name synonym)|uniprotkb:HNLX(gene name synonym)|uniprotkb:UNQ365/PRO701(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Leone et al. (2010) pubmed:20543817|imex:IM-15017|mint:MINT-7988457|doi:10.1038/emboj.2010.123 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8017678|mint:MINT-7988534|imex:IM-15017-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1780696(isoform-parent)|mint:MINT-7988537(identity) refseq:XP_011543849.1|refseq:XP_011543850.1|refseq:XP_006724567.1|refseq:XP_016885179.1|refseq:XP_016885180.1|refseq:XP_016885181.1|refseq:XP_016885182.1|refseq:NP_065793.1|refseq:NP_851849.1|refseq:NP_001269074.1|refseq:NP_001269075.1|refseq:XP_005274621.1|refseq:XP_005274622.1|refseq:XP_005274623.1|go:"GO:0098985"(asymmetric, glutamatergic, excitatory synapse)|go:"GO:0099054"(presynapse assembly)|interpro:IPR000460(Neuroligin)|interpro:IPR002018(Carboxylesterase, type B)|interpro:IPR019819|interpro:IPR029058|interpro:IPR030025|rcsb pdb:2WQZ|rcsb pdb:2XB6|rcsb pdb:3BE8|reactome:R-HSA-6794361|ensembl:ENSG00000146938(gene)|ensembl:ENST00000275857(transcript)|ensembl:ENST00000381092(transcript)|ensembl:ENST00000381093(transcript)|ensembl:ENST00000381095(transcript)|go:"GO:0003360"(brainstem development)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0021549"(cerebellum development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0031404"(chloride ion binding)|go:"GO:0035176"(social behavior)|go:"GO:0035265"(organ growth)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045202"(synapse)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060076"(excitatory synapse)|go:"GO:0071625"(vocalization behavior)|go:"GO:0089717"(spanning component of membrane)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098793"(presynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098983"(symmetric, GABA-ergic, inhibitory synapse)|mint:MINT-7988543(identity) - - - comment:mint|figure legend:f3b f3d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.9x10^-7(molar) 2010/08/03 2018/12/03 rogid:voabMMncKJwjAiQ4kdUcGukdtUw10116 rogid:7PtRrX28usbCkTHxS8QfWEgDEn49606 intact-crc:13540898191EE85F|rigid:GYDCp0waGqOmIPmT7kDMdCuueu4 false binding-associated region:81-258(MINT-7988540)|mutation decreasing interaction:103-103(MINT-7988538) binding-associated region:44-619(MINT-7988544) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q63373-3 uniprotkb:Q62765-2 intact:EBI-20994045 intact:EBI-20994039 psi-mi:q63373-3(display_long)|uniprotkb:Neurexin I-beta(gene name synonym)|uniprotkb:Beta-4B5A(isoform synonym)|uniprotkb:Nrxn1(gene name)|psi-mi:Nrxn1(display_short) psi-mi:q62765-2(display_long)|uniprotkb:Neuroligin I(gene name synonym)|uniprotkb:Nlgn1(gene name)|psi-mi:Nlgn1(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Leone et al. (2010) pubmed:20543817|imex:IM-15017|mint:MINT-7988457|doi:10.1038/emboj.2010.123 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8017759|mint:MINT-7988566|imex:IM-15017-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1780696(isoform-parent)|mint:MINT-7988573(identity) intact:EBI-7281118(isoform-parent)|mint:MINT-7988569(identity) - - isoform-comment:No experimental confirmation available. figure legend:f3a f3c|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:8.3x10^-8(molar) 2010/08/03 2018/12/03 rogid:voabMMncKJwjAiQ4kdUcGukdtUw10116 rogid:Nmx72I+D36c9ZpLnzKKLVBvaM8g10116 intact-crc:E46796EC7A014F35|rigid:4joCliOiSCLMgLVUzvVK6S1es6Y false mutation decreasing interaction:109-109(MINT-7988576)|binding-associated region:81-258(MINT-7988574) binding-associated region:46-609(MINT-7988570) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q63373-3 uniprotkb:Q62765-2 intact:EBI-20994045 intact:EBI-20994039 psi-mi:q63373-3(display_long)|uniprotkb:Neurexin I-beta(gene name synonym)|uniprotkb:Beta-4B5A(isoform synonym)|uniprotkb:Nrxn1(gene name)|psi-mi:Nrxn1(display_short) psi-mi:q62765-2(display_long)|uniprotkb:Neuroligin I(gene name synonym)|uniprotkb:Nlgn1(gene name)|psi-mi:Nlgn1(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Leone et al. (2010) pubmed:20543817|imex:IM-15017|mint:MINT-7988457|doi:10.1038/emboj.2010.123 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8017781|mint:MINT-7988582|imex:IM-15017-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1780696(isoform-parent)|mint:MINT-7988585(identity) intact:EBI-7281118(isoform-parent)|mint:MINT-7988591(identity) - - isoform-comment:No experimental confirmation available. figure legend:f3a f3c|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.05x10^-7(molar) 2010/08/03 2018/12/03 rogid:voabMMncKJwjAiQ4kdUcGukdtUw10116 rogid:Nmx72I+D36c9ZpLnzKKLVBvaM8g10116 intact-crc:C11526BD08CF47C3|rigid:4joCliOiSCLMgLVUzvVK6S1es6Y false binding-associated region:81-258(MINT-7988588)|mutation decreasing interaction:202-202(MINT-7988586) binding-associated region:46-609(MINT-7988592) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q63373-3 uniprotkb:Q62765-2 intact:EBI-20994045 intact:EBI-20994039 psi-mi:q63373-3(display_long)|uniprotkb:Neurexin I-beta(gene name synonym)|uniprotkb:Beta-4B5A(isoform synonym)|uniprotkb:Nrxn1(gene name)|psi-mi:Nrxn1(display_short) psi-mi:q62765-2(display_long)|uniprotkb:Neuroligin I(gene name synonym)|uniprotkb:Nlgn1(gene name)|psi-mi:Nlgn1(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Leone et al. (2010) pubmed:20543817|imex:IM-15017|mint:MINT-7988457|doi:10.1038/emboj.2010.123 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8017803|mint:MINT-7988598|imex:IM-15017-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1780696(isoform-parent)|mint:MINT-7988605(identity) intact:EBI-7281118(isoform-parent)|mint:MINT-7988601(identity) - - isoform-comment:No experimental confirmation available. figure legend:f3a f3c|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.6x10^-8(molar) 2010/08/03 2018/12/03 rogid:voabMMncKJwjAiQ4kdUcGukdtUw10116 rogid:Nmx72I+D36c9ZpLnzKKLVBvaM8g10116 intact-crc:090B31C6584F9803|rigid:4joCliOiSCLMgLVUzvVK6S1es6Y false mutation disrupting interaction:206-206(MINT-7988608)|binding-associated region:81-258(MINT-7988606) binding-associated region:46-609(MINT-7988602) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q62765-2 uniprotkb:Q63373-3 intact:EBI-20994039 intact:EBI-20994045 psi-mi:q62765-2(display_long)|uniprotkb:Neuroligin I(gene name synonym)|uniprotkb:Nlgn1(gene name)|psi-mi:Nlgn1(display_short) psi-mi:q63373-3(display_long)|uniprotkb:Neurexin I-beta(gene name synonym)|uniprotkb:Beta-4B5A(isoform synonym)|uniprotkb:Nrxn1(gene name)|psi-mi:Nrxn1(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Leone et al. (2010) pubmed:20543817|imex:IM-15017|mint:MINT-7988457|doi:10.1038/emboj.2010.123 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8017842|mint:MINT-7988614|imex:IM-15017-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7281118(isoform-parent)|mint:MINT-7988623(identity) intact:EBI-1780696(isoform-parent)|mint:MINT-7988617(identity) - isoform-comment:No experimental confirmation available. - comment:mint|figure legend:f4c sf3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/08/03 2018/12/03 rogid:Nmx72I+D36c9ZpLnzKKLVBvaM8g10116 rogid:voabMMncKJwjAiQ4kdUcGukdtUw10116 intact-crc:0A37844C7DB28A77|rigid:4joCliOiSCLMgLVUzvVK6S1es6Y false mutation disrupting interaction:471-471(MINT-7988632)|binding-associated region:46-609(MINT-7988624) binding-associated region:81-258(MINT-7988620) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q62888-2 uniprotkb:Q63373-3 intact:EBI-20994089 intact:EBI-20994045 psi-mi:q62888-2(display_long)|uniprotkb:Nlgn2(gene name)|psi-mi:Nlgn2(display_short) psi-mi:q63373-3(display_long)|uniprotkb:Neurexin I-beta(gene name synonym)|uniprotkb:Beta-4B5A(isoform synonym)|uniprotkb:Nrxn1(gene name)|psi-mi:Nrxn1(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Leone et al. (2010) pubmed:20543817|imex:IM-15017|mint:MINT-7988457|doi:10.1038/emboj.2010.123 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8017864|mint:MINT-7988637|imex:IM-15017-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-7281302(isoform-parent)|mint:MINT-7988639(identity) intact:EBI-1780696(isoform-parent)|mint:MINT-7988645(identity) - - - figure legend:f4c|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/08/03 2018/12/03 rogid:yvvAOQxgpoOj3iV9MA4M28w/KK010116 rogid:voabMMncKJwjAiQ4kdUcGukdtUw10116 intact-crc:7F5C443D0A44B98C|rigid:EpcMJCBS4B5xy2+atMoWVZue8GY false binding-associated region:65-598(MINT-7988642)|mutation increasing interaction:458-458(MINT-7988640) binding-associated region:81-258(MINT-7988646) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)