#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O00470	uniprotkb:P40424	intact:EBI-1210694|uniprotkb:A8MV50|ensembl:ENSP00000272369	intact:EBI-301611|uniprotkb:Q5T488|ensembl:ENSP00000405890|uniprotkb:B4DSC1|uniprotkb:F5H4U9	psi-mi:meis1_human(display_long)|uniprotkb:MEIS1(gene name)|psi-mi:MEIS1(display_short)	psi-mi:pbx1_human(display_long)|uniprotkb:PBX1(gene name)|psi-mi:PBX1(display_short)|uniprotkb:PRL(gene name synonym)|uniprotkb:Homeobox protein PBX1(gene name synonym)|uniprotkb:Homeobox protein PRL(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2010)	imex:IM-14346|pubmed:20541704	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2879874|imex:IM-14346-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002389.1|ensembl:ENSG00000143995(gene)|ensembl:ENST00000272369(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001654"(eye development)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR001356(Homeobox)|interpro:IPR008422(Coprinus cinereus mating-type protein)|interpro:IPR009057(Homeodomain-like)|interpro:IPR032453|rcsb pdb:4XRS|rcsb pdb:5EGO|reactome:R-HSA-5617472	refseq:NP_001191892.1|refseq:NP_002576.1|go:"GO:0007420"(brain development)|go:"GO:0007548"(sex differentiation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0048666"(neuron development)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR005542(PBX)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|rcsb pdb:1B72|go:"GO:0005634"(nucleus)|rcsb pdb:1PUF|reactome:R-HSA-452723|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006694"(steroid biosynthetic process)|reactome:R-HSA-5617472|reactome:R-HSA-9013508|ensembl:ENSG00000185630(gene)|ensembl:ENST00000420696(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0003677"(DNA binding)|refseq:XP_005245286.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 5A.|antagonist:SB216763 - a GSK-3 inhibitor.|comment:"Transfected exogenous CREB in 293T cells and endogenous CREB in (murine) AML cells transformed by HOXA9/MEIS1 coprecipitated with MEIS1.  GSK-3 inhibitor treatment markedly reduced MEIS1-CREB coimmunoprecipitation, but not interaction of MEIS1 with its dimerization partner PBX1b."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/06/24	2020/10/21	rogid:X2N9fFxk9ZD7VQHf1oWkxJAtzsc9606	rogid:YViNj+q9A6e+VCAkMUQowMzvowE9606	intact-crc:1B63136E42E8CF28|rigid:NVlyU4PjtkLWqyOPAYZWLUGK8QI	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00470	uniprotkb:P16220	intact:EBI-1210694|uniprotkb:A8MV50|ensembl:ENSP00000272369	intact:EBI-711855|uniprotkb:P21934|uniprotkb:Q9UMA7|intact:EBI-28970080|ensembl:ENSP00000236995|ensembl:ENSP00000405539|uniprotkb:Q6V963	psi-mi:meis1_human(display_long)|uniprotkb:MEIS1(gene name)|psi-mi:MEIS1(display_short)	psi-mi:creb1_human(display_long)|uniprotkb:CREB1(gene name)|psi-mi:CREB1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2010)	imex:IM-14346|pubmed:20541704	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2879874|imex:IM-14346-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002389.1|ensembl:ENSG00000143995(gene)|ensembl:ENST00000272369(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001654"(eye development)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR001356(Homeobox)|interpro:IPR008422(Coprinus cinereus mating-type protein)|interpro:IPR009057(Homeodomain-like)|interpro:IPR032453|rcsb pdb:4XRS|rcsb pdb:5EGO|reactome:R-HSA-5617472	go:"GO:0000791"(euchromatin)|ensembl:ENSG00000118260(gene)|ensembl:ENST00000353267(transcript)|ensembl:ENST00000430624(transcript)|go:"GO:0000785"(chromatin)|ensembl:ENSP00000236995|ensembl:ENSP00000405539|ensembl:ENST00000432329|ensembl:ENSP00000387699|refseq:NP_004370.1|refseq:NP_604391.1|refseq:XP_011508947.1|dip:DIP-765N|refseq:XP_011508949.1|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007568"(aging)|go:"GO:0007595"(lactation)|go:"GO:0007613"(memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008542"(visual learning)|go:"GO:0010033"(response to organic substance)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0014823"(response to activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030424"(axon)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032916"(positive regulation of transforming growth factor beta3 production)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033762"(response to glucagon)|go:"GO:0034670"(chemotaxis to arachidonic acid)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035094"(response to nicotine)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0055025"(positive regulation of cardiac muscle tissue development)|go:"GO:0060251"(regulation of glial cell proliferation)|go:"GO:0060430"(lung saccule development)|go:"GO:0060509"(type I pneumocyte differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990589"(ATF4-CREB1 transcription factor complex)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001630("cAMP response element binding (CREB) protein")|interpro:IPR003102(Coactivator CBP, pKID)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029802|mint:P16220|rcsb pdb:2LXT|rcsb pdb:5ZK1|rcsb pdb:5ZKO|reactome:R-HSA-111931|reactome:R-HSA-111932|reactome:R-HSA-198693|reactome:R-HSA-199920|reactome:R-HSA-2151201|reactome:R-HSA-2197563|reactome:R-HSA-375165|reactome:R-HSA-400253|reactome:R-HSA-442720|reactome:R-HSA-442729|reactome:R-HSA-442742|reactome:R-HSA-5674400|reactome:R-HSA-881907|reactome:R-HSA-9022692|reactome:R-HSA-9022699|reactome:R-HSA-9022702|reactome:R-HSA-9022707|reactome:R-HSA-9031628|reactome:R-HSA-9609690|reactome:R-HSA-9616222|reactome:R-HSA-9634638|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-9707616	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 5A.|antagonist:SB216763 - a GSK-3 inhibitor.|comment:"Transfected exogenous CREB in 293T cells and endogenous CREB in (murine) AML cells transformed by HOXA9/MEIS1 coprecipitated with MEIS1.  GSK-3 inhibitor treatment markedly reduced MEIS1-CREB coimmunoprecipitation, but not interaction of MEIS1 with its dimerization partner PBX1b."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/06/24	2020/10/21	rogid:X2N9fFxk9ZD7VQHf1oWkxJAtzsc9606	rogid:+gDlECcpJ4ma+wfUc19mIXyACKU9606	intact-crc:1B63136E42E8CF28|rigid:NVlyU4PjtkLWqyOPAYZWLUGK8QI	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00470	uniprotkb:Q92793	intact:EBI-1210694|uniprotkb:A8MV50|ensembl:ENSP00000272369	intact:EBI-81215|ensembl:ENSP00000262367|uniprotkb:O00147|uniprotkb:Q16376|uniprotkb:D3DUC9|uniprotkb:Q4LE28	psi-mi:meis1_human(display_long)|uniprotkb:MEIS1(gene name)|psi-mi:MEIS1(display_short)	psi-mi:cbp_human(display_long)|uniprotkb:CREBBP(gene name)|psi-mi:CREBBP(display_short)|uniprotkb:CBP(gene name synonym)|uniprotkb:Histone lysine acetyltransferase CREBBP(gene name synonym)|uniprotkb:Protein-lysine acetyltransferase CREBBP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2010)	imex:IM-14346|pubmed:20541704	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2879982|imex:IM-14346-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002389.1|ensembl:ENSG00000143995(gene)|ensembl:ENST00000272369(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001654"(eye development)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR001356(Homeobox)|interpro:IPR008422(Coprinus cinereus mating-type protein)|interpro:IPR009057(Homeodomain-like)|interpro:IPR032453|rcsb pdb:4XRS|rcsb pdb:5EGO|reactome:R-HSA-5617472	ensembl:ENSG00000005339(gene)|ensembl:ENST00000262367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000785"(chromatin)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006473"(protein acetylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0018076"(N-terminal peptidyl-lysine acetylation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0034212"(peptide N-acetyltransferase activity)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042592"(homeostatic process)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043426"(MRF binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061733"(peptide-lysine-N-acetyltransferase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1990258"(histone glutamine methylation)|interpro:IPR000197(Zinc finger, TAZ-type)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR001487(Bromodomain)|interpro:IPR003101(Coactivator CBP, KIX)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010303(Protein of unknown function DUF902, CREBbp)|rcsb pdb:1WO7|rcsb pdb:1ZOQ|rcsb pdb:2D82|rcsb pdb:2KJE|rcsb pdb:2KWF|rcsb pdb:2L84|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013178(H3K56 histone acetylation protein, RTT109)|interpro:IPR014744(Nuclear receptor coactivator, CREB-bp-like, interlocking)|interpro:IPR018359|interpro:IPR031162|interpro:IPR035898|interpro:IPR036427|interpro:IPR036529|interpro:IPR037073|interpro:IPR038547|interpro:IPR043145|mint:Q92793|rcsb pdb:1JSP|rcsb pdb:1LIQ|rcsb pdb:1RDT|rcsb pdb:1WO3|rcsb pdb:1WO4|rcsb pdb:1WO5|rcsb pdb:1WO6|rcsb pdb:2L85|rcsb pdb:2LXT|rcsb pdb:2LXS|rcsb pdb:3DWY|rcsb pdb:2N1A|rcsb pdb:3P1C|rcsb pdb:3P1D|refseq:NP_001073315.1|refseq:NP_004371.2|rcsb pdb:3P1E|rcsb pdb:3P1F|rcsb pdb:2RNY|rcsb pdb:6AY3|rcsb pdb:6AY5|rcsb pdb:6DMK|rcsb pdb:6ES5|rcsb pdb:6ES6|rcsb pdb:6ES7|rcsb pdb:6SQM|rcsb pdb:6FQO|rcsb pdb:6SXX|rcsb pdb:6YIJ|rcsb pdb:6YIK|rcsb pdb:6YIL|rcsb pdb:6YIM|rcsb pdb:6FQT|rcsb pdb:7CO1|rcsb pdb:7JFL|rcsb pdb:7JFM|reactome:R-HSA-1234158|rcsb pdb:6FQU|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-1912408|rcsb pdb:6FR0|rcsb pdb:6FRF|rcsb pdb:6M64|rcsb pdb:6QST|reactome:R-HSA-1989781|reactome:R-HSA-201722|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-2644606|rcsb pdb:6SQE|rcsb pdb:6SQF|reactome:R-HSA-2894862|reactome:R-HSA-3134973|reactome:R-HSA-3214847|reactome:R-HSA-3371568|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-5617472|reactome:R-HSA-5621575|reactome:R-HSA-6803204|reactome:R-HSA-8866907|reactome:R-HSA-8939246|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|reactome:R-HSA-9018519|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-9614657|rcsb pdb:3SVH|rcsb pdb:4A9K|rcsb pdb:4N3W|rcsb pdb:4N4F|rcsb pdb:4NR4|rcsb pdb:4NR5|rcsb pdb:4NR6|rcsb pdb:4NR7|rcsb pdb:4NYV|rcsb pdb:4NYW|rcsb pdb:4NYX|rcsb pdb:4OUF|rcsb pdb:4TQN|rcsb pdb:4TS8|rcsb pdb:4WHU|rcsb pdb:4YK0|rcsb pdb:5CGP|rcsb pdb:5DBM|rcsb pdb:5EIC|rcsb pdb:5ENG|rcsb pdb:5EP7|rcsb pdb:5GH9|rcsb pdb:5H85|rcsb pdb:5I83|rcsb pdb:5I86|rcsb pdb:5I89|rcsb pdb:5I8B|rcsb pdb:5I8G|rcsb pdb:5J0D|rcsb pdb:5JEM|rcsb pdb:5KTU|rcsb pdb:5KTW|rcsb pdb:5KTX|rcsb pdb:5LPJ|rcsb pdb:5LPL|rcsb pdb:5MME|rcsb pdb:5MMG|rcsb pdb:5MPK|rcsb pdb:5MPN|rcsb pdb:5MPZ|rcsb pdb:5MQE|rcsb pdb:5MQG|rcsb pdb:5MQK|rcsb pdb:5NLK|rcsb pdb:5NRW|rcsb pdb:5NU3|rcsb pdb:5OWK|rcsb pdb:5SVH|rcsb pdb:5TB6|rcsb pdb:5W0E|rcsb pdb:5W0F|rcsb pdb:5W0L|rcsb pdb:5W0Q|rcsb pdb:5XXH|rcsb pdb:6ALB|rcsb pdb:6ALC|rcsb pdb:6AXQ|reactome:R-HSA-9707564|reactome:R-HSA-9707616|reactome:R-HSA-9617629|dip:DIP-952N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 5D.|antagonist:SB216763 - a GSK-3 inhibitor.|comment:MEIS1 also coprecipitated the CREB coactivators CBP and TORC, which was markedly reduced by GSK-3 inhibition.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/06/24	2020/10/21	rogid:X2N9fFxk9ZD7VQHf1oWkxJAtzsc9606	rogid:WWX7TFIpcDwoR5f5Sm1eQ6nma1E9606	intact-crc:F5D19BE632B5A489|rigid:+x2F/AczYNrZrcgQ/tBUapZZ6Y0	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00470	uniprotkb:P16220	intact:EBI-1210694|uniprotkb:A8MV50|ensembl:ENSP00000272369	intact:EBI-711855|uniprotkb:P21934|uniprotkb:Q9UMA7|intact:EBI-28970080|ensembl:ENSP00000236995|ensembl:ENSP00000405539|uniprotkb:Q6V963	psi-mi:meis1_human(display_long)|uniprotkb:MEIS1(gene name)|psi-mi:MEIS1(display_short)	psi-mi:creb1_human(display_long)|uniprotkb:CREB1(gene name)|psi-mi:CREB1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2010)	imex:IM-14346|pubmed:20541704	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2879982|imex:IM-14346-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002389.1|ensembl:ENSG00000143995(gene)|ensembl:ENST00000272369(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001654"(eye development)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR001356(Homeobox)|interpro:IPR008422(Coprinus cinereus mating-type protein)|interpro:IPR009057(Homeodomain-like)|interpro:IPR032453|rcsb pdb:4XRS|rcsb pdb:5EGO|reactome:R-HSA-5617472	go:"GO:0000791"(euchromatin)|ensembl:ENSG00000118260(gene)|ensembl:ENST00000353267(transcript)|ensembl:ENST00000430624(transcript)|go:"GO:0000785"(chromatin)|ensembl:ENSP00000236995|ensembl:ENSP00000405539|ensembl:ENST00000432329|ensembl:ENSP00000387699|refseq:NP_004370.1|refseq:NP_604391.1|refseq:XP_011508947.1|dip:DIP-765N|refseq:XP_011508949.1|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007568"(aging)|go:"GO:0007595"(lactation)|go:"GO:0007613"(memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008542"(visual learning)|go:"GO:0010033"(response to organic substance)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0014823"(response to activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030424"(axon)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032916"(positive regulation of transforming growth factor beta3 production)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033762"(response to glucagon)|go:"GO:0034670"(chemotaxis to arachidonic acid)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035094"(response to nicotine)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0055025"(positive regulation of cardiac muscle tissue development)|go:"GO:0060251"(regulation of glial cell proliferation)|go:"GO:0060430"(lung saccule development)|go:"GO:0060509"(type I pneumocyte differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990589"(ATF4-CREB1 transcription factor complex)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001630("cAMP response element binding (CREB) protein")|interpro:IPR003102(Coactivator CBP, pKID)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029802|mint:P16220|rcsb pdb:2LXT|rcsb pdb:5ZK1|rcsb pdb:5ZKO|reactome:R-HSA-111931|reactome:R-HSA-111932|reactome:R-HSA-198693|reactome:R-HSA-199920|reactome:R-HSA-2151201|reactome:R-HSA-2197563|reactome:R-HSA-375165|reactome:R-HSA-400253|reactome:R-HSA-442720|reactome:R-HSA-442729|reactome:R-HSA-442742|reactome:R-HSA-5674400|reactome:R-HSA-881907|reactome:R-HSA-9022692|reactome:R-HSA-9022699|reactome:R-HSA-9022702|reactome:R-HSA-9022707|reactome:R-HSA-9031628|reactome:R-HSA-9609690|reactome:R-HSA-9616222|reactome:R-HSA-9634638|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-9707616	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 5D.|antagonist:SB216763 - a GSK-3 inhibitor.|comment:MEIS1 also coprecipitated the CREB coactivators CBP and TORC, which was markedly reduced by GSK-3 inhibition.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/06/24	2020/10/21	rogid:X2N9fFxk9ZD7VQHf1oWkxJAtzsc9606	rogid:+gDlECcpJ4ma+wfUc19mIXyACKU9606	intact-crc:F5D19BE632B5A489|rigid:+x2F/AczYNrZrcgQ/tBUapZZ6Y0	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92793	uniprotkb:P16220	intact:EBI-81215|ensembl:ENSP00000262367|uniprotkb:O00147|uniprotkb:Q16376|uniprotkb:D3DUC9|uniprotkb:Q4LE28	intact:EBI-711855|uniprotkb:P21934|uniprotkb:Q9UMA7|intact:EBI-28970080|ensembl:ENSP00000236995|ensembl:ENSP00000405539|uniprotkb:Q6V963	psi-mi:cbp_human(display_long)|uniprotkb:CREBBP(gene name)|psi-mi:CREBBP(display_short)|uniprotkb:CBP(gene name synonym)|uniprotkb:Histone lysine acetyltransferase CREBBP(gene name synonym)|uniprotkb:Protein-lysine acetyltransferase CREBBP(gene name synonym)	psi-mi:creb1_human(display_long)|uniprotkb:CREB1(gene name)|psi-mi:CREB1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2010)	imex:IM-14346|pubmed:20541704	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2880014|imex:IM-14346-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000005339(gene)|ensembl:ENST00000262367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000785"(chromatin)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006473"(protein acetylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0018076"(N-terminal peptidyl-lysine acetylation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0034212"(peptide N-acetyltransferase activity)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042592"(homeostatic process)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043426"(MRF binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061733"(peptide-lysine-N-acetyltransferase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1990258"(histone glutamine methylation)|interpro:IPR000197(Zinc finger, TAZ-type)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR001487(Bromodomain)|interpro:IPR003101(Coactivator CBP, KIX)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010303(Protein of unknown function DUF902, CREBbp)|rcsb pdb:1WO7|rcsb pdb:1ZOQ|rcsb pdb:2D82|rcsb pdb:2KJE|rcsb pdb:2KWF|rcsb pdb:2L84|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013178(H3K56 histone acetylation protein, RTT109)|interpro:IPR014744(Nuclear receptor coactivator, CREB-bp-like, interlocking)|interpro:IPR018359|interpro:IPR031162|interpro:IPR035898|interpro:IPR036427|interpro:IPR036529|interpro:IPR037073|interpro:IPR038547|interpro:IPR043145|mint:Q92793|rcsb pdb:1JSP|rcsb pdb:1LIQ|rcsb pdb:1RDT|rcsb pdb:1WO3|rcsb pdb:1WO4|rcsb pdb:1WO5|rcsb pdb:1WO6|rcsb pdb:2L85|rcsb pdb:2LXT|rcsb pdb:2LXS|rcsb pdb:3DWY|rcsb pdb:2N1A|rcsb pdb:3P1C|rcsb pdb:3P1D|refseq:NP_001073315.1|refseq:NP_004371.2|rcsb pdb:3P1E|rcsb pdb:3P1F|rcsb pdb:2RNY|rcsb pdb:6AY3|rcsb pdb:6AY5|rcsb pdb:6DMK|rcsb pdb:6ES5|rcsb pdb:6ES6|rcsb pdb:6ES7|rcsb pdb:6SQM|rcsb pdb:6FQO|rcsb pdb:6SXX|rcsb pdb:6YIJ|rcsb pdb:6YIK|rcsb pdb:6YIL|rcsb pdb:6YIM|rcsb pdb:6FQT|rcsb pdb:7CO1|rcsb pdb:7JFL|rcsb pdb:7JFM|reactome:R-HSA-1234158|rcsb pdb:6FQU|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-1912408|rcsb pdb:6FR0|rcsb pdb:6FRF|rcsb pdb:6M64|rcsb pdb:6QST|reactome:R-HSA-1989781|reactome:R-HSA-201722|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-2644606|rcsb pdb:6SQE|rcsb pdb:6SQF|reactome:R-HSA-2894862|reactome:R-HSA-3134973|reactome:R-HSA-3214847|reactome:R-HSA-3371568|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-5617472|reactome:R-HSA-5621575|reactome:R-HSA-6803204|reactome:R-HSA-8866907|reactome:R-HSA-8939246|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|reactome:R-HSA-9018519|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-9614657|rcsb pdb:3SVH|rcsb pdb:4A9K|rcsb pdb:4N3W|rcsb pdb:4N4F|rcsb pdb:4NR4|rcsb pdb:4NR5|rcsb pdb:4NR6|rcsb pdb:4NR7|rcsb pdb:4NYV|rcsb pdb:4NYW|rcsb pdb:4NYX|rcsb pdb:4OUF|rcsb pdb:4TQN|rcsb pdb:4TS8|rcsb pdb:4WHU|rcsb pdb:4YK0|rcsb pdb:5CGP|rcsb pdb:5DBM|rcsb pdb:5EIC|rcsb pdb:5ENG|rcsb pdb:5EP7|rcsb pdb:5GH9|rcsb pdb:5H85|rcsb pdb:5I83|rcsb pdb:5I86|rcsb pdb:5I89|rcsb pdb:5I8B|rcsb pdb:5I8G|rcsb pdb:5J0D|rcsb pdb:5JEM|rcsb pdb:5KTU|rcsb pdb:5KTW|rcsb pdb:5KTX|rcsb pdb:5LPJ|rcsb pdb:5LPL|rcsb pdb:5MME|rcsb pdb:5MMG|rcsb pdb:5MPK|rcsb pdb:5MPN|rcsb pdb:5MPZ|rcsb pdb:5MQE|rcsb pdb:5MQG|rcsb pdb:5MQK|rcsb pdb:5NLK|rcsb pdb:5NRW|rcsb pdb:5NU3|rcsb pdb:5OWK|rcsb pdb:5SVH|rcsb pdb:5TB6|rcsb pdb:5W0E|rcsb pdb:5W0F|rcsb pdb:5W0L|rcsb pdb:5W0Q|rcsb pdb:5XXH|rcsb pdb:6ALB|rcsb pdb:6ALC|rcsb pdb:6AXQ|reactome:R-HSA-9707564|reactome:R-HSA-9707616|reactome:R-HSA-9617629|dip:DIP-952N	go:"GO:0000791"(euchromatin)|ensembl:ENSG00000118260(gene)|ensembl:ENST00000353267(transcript)|ensembl:ENST00000430624(transcript)|go:"GO:0000785"(chromatin)|ensembl:ENSP00000236995|ensembl:ENSP00000405539|ensembl:ENST00000432329|ensembl:ENSP00000387699|refseq:NP_004370.1|refseq:NP_604391.1|refseq:XP_011508947.1|dip:DIP-765N|refseq:XP_011508949.1|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007568"(aging)|go:"GO:0007595"(lactation)|go:"GO:0007613"(memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008542"(visual learning)|go:"GO:0010033"(response to organic substance)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0014823"(response to activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030424"(axon)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032916"(positive regulation of transforming growth factor beta3 production)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033762"(response to glucagon)|go:"GO:0034670"(chemotaxis to arachidonic acid)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035094"(response to nicotine)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0055025"(positive regulation of cardiac muscle tissue development)|go:"GO:0060251"(regulation of glial cell proliferation)|go:"GO:0060430"(lung saccule development)|go:"GO:0060509"(type I pneumocyte differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990589"(ATF4-CREB1 transcription factor complex)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001630("cAMP response element binding (CREB) protein")|interpro:IPR003102(Coactivator CBP, pKID)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029802|mint:P16220|rcsb pdb:2LXT|rcsb pdb:5ZK1|rcsb pdb:5ZKO|reactome:R-HSA-111931|reactome:R-HSA-111932|reactome:R-HSA-198693|reactome:R-HSA-199920|reactome:R-HSA-2151201|reactome:R-HSA-2197563|reactome:R-HSA-375165|reactome:R-HSA-400253|reactome:R-HSA-442720|reactome:R-HSA-442729|reactome:R-HSA-442742|reactome:R-HSA-5674400|reactome:R-HSA-881907|reactome:R-HSA-9022692|reactome:R-HSA-9022699|reactome:R-HSA-9022702|reactome:R-HSA-9022707|reactome:R-HSA-9031628|reactome:R-HSA-9609690|reactome:R-HSA-9616222|reactome:R-HSA-9634638|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-9707616	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 5F.|antagonist:SB216763 - a GSK-3 inhibitor.|comment:CBP coIP was dependent on the presence of CREB, and abrogated in the CREB phosphorylation mutants, or by GSK-3 inhibition.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/06/24	2020/10/21	rogid:WWX7TFIpcDwoR5f5Sm1eQ6nma1E9606	rogid:+gDlECcpJ4ma+wfUc19mIXyACKU9606	intact-crc:164D4490FBB155CF|rigid:rFk7BKFDfxY2ya6bj2+PNVZeML4	false	-	flag tag:?-?|mutation decreasing interaction:115-115|mutation decreasing interaction:119-119	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00470	uniprotkb:P16220	intact:EBI-1210694|uniprotkb:A8MV50|ensembl:ENSP00000272369	intact:EBI-711855|uniprotkb:P21934|uniprotkb:Q9UMA7|intact:EBI-28970080|ensembl:ENSP00000236995|ensembl:ENSP00000405539|uniprotkb:Q6V963	psi-mi:meis1_human(display_long)|uniprotkb:MEIS1(gene name)|psi-mi:MEIS1(display_short)	psi-mi:creb1_human(display_long)|uniprotkb:CREB1(gene name)|psi-mi:CREB1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2010)	imex:IM-14346|pubmed:20541704	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2889314|imex:IM-14346-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002389.1|ensembl:ENSG00000143995(gene)|ensembl:ENST00000272369(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001654"(eye development)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR001356(Homeobox)|interpro:IPR008422(Coprinus cinereus mating-type protein)|interpro:IPR009057(Homeodomain-like)|interpro:IPR032453|rcsb pdb:4XRS|rcsb pdb:5EGO|reactome:R-HSA-5617472	go:"GO:0000791"(euchromatin)|ensembl:ENSG00000118260(gene)|ensembl:ENST00000353267(transcript)|ensembl:ENST00000430624(transcript)|go:"GO:0000785"(chromatin)|ensembl:ENSP00000236995|ensembl:ENSP00000405539|ensembl:ENST00000432329|ensembl:ENSP00000387699|refseq:NP_004370.1|refseq:NP_604391.1|refseq:XP_011508947.1|dip:DIP-765N|refseq:XP_011508949.1|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007568"(aging)|go:"GO:0007595"(lactation)|go:"GO:0007613"(memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008542"(visual learning)|go:"GO:0010033"(response to organic substance)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0014823"(response to activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030424"(axon)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032916"(positive regulation of transforming growth factor beta3 production)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033762"(response to glucagon)|go:"GO:0034670"(chemotaxis to arachidonic acid)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035094"(response to nicotine)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0055025"(positive regulation of cardiac muscle tissue development)|go:"GO:0060251"(regulation of glial cell proliferation)|go:"GO:0060430"(lung saccule development)|go:"GO:0060509"(type I pneumocyte differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990589"(ATF4-CREB1 transcription factor complex)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001630("cAMP response element binding (CREB) protein")|interpro:IPR003102(Coactivator CBP, pKID)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029802|mint:P16220|rcsb pdb:2LXT|rcsb pdb:5ZK1|rcsb pdb:5ZKO|reactome:R-HSA-111931|reactome:R-HSA-111932|reactome:R-HSA-198693|reactome:R-HSA-199920|reactome:R-HSA-2151201|reactome:R-HSA-2197563|reactome:R-HSA-375165|reactome:R-HSA-400253|reactome:R-HSA-442720|reactome:R-HSA-442729|reactome:R-HSA-442742|reactome:R-HSA-5674400|reactome:R-HSA-881907|reactome:R-HSA-9022692|reactome:R-HSA-9022699|reactome:R-HSA-9022702|reactome:R-HSA-9022707|reactome:R-HSA-9031628|reactome:R-HSA-9609690|reactome:R-HSA-9616222|reactome:R-HSA-9634638|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-9707616	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 5H.|comment:MEIS1/CREB association depends on TORC2.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/06/24	2020/10/21	rogid:X2N9fFxk9ZD7VQHf1oWkxJAtzsc9606	rogid:+gDlECcpJ4ma+wfUc19mIXyACKU9606	intact-crc:6B9F7D6D17423767|rigid:7GxkeDge9ZJGXRXeSRWDWOHKGfQ	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00470	uniprotkb:Q01147	intact:EBI-1210694|uniprotkb:A8MV50|ensembl:ENSP00000272369	intact:EBI-2291098|ensembl:ENSMUSP00000084624|ensembl:ENSMUSP00000139995	psi-mi:meis1_human(display_long)|uniprotkb:MEIS1(gene name)|psi-mi:MEIS1(display_short)	psi-mi:creb1_mouse(display_long)|uniprotkb:Creb1(gene name)|psi-mi:Creb1(display_short)|uniprotkb:Creb-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2010)	imex:IM-14346|pubmed:20541704	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2879898|imex:IM-14346-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002389.1|ensembl:ENSG00000143995(gene)|ensembl:ENST00000272369(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001654"(eye development)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR001356(Homeobox)|interpro:IPR008422(Coprinus cinereus mating-type protein)|interpro:IPR009057(Homeodomain-like)|interpro:IPR032453|rcsb pdb:4XRS|rcsb pdb:5EGO|reactome:R-HSA-5617472	refseq:NP_034082.1|refseq:NP_598589.2|refseq:XP_006495713.1|refseq:XP_006495714.1|refseq:XP_017169569.1|refseq:XP_017169588.1|ensembl:ENSMUSG00000025958(gene)|ensembl:ENSMUST00000087366(transcript)|ensembl:ENSMUST00000185594(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007568"(aging)|go:"GO:0007595"(lactation)|go:"GO:0007613"(memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008542"(visual learning)|go:"GO:0010033"(response to organic substance)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0014823"(response to activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030424"(axon)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030879"(mammary gland development)|go:"GO:0032916"(positive regulation of transforming growth factor beta3 production)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033762"(response to glucagon)|go:"GO:0034670"(chemotaxis to arachidonic acid)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035094"(response to nicotine)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0055025"(positive regulation of cardiac muscle tissue development)|go:"GO:0060251"(regulation of glial cell proliferation)|go:"GO:0060428"(lung epithelium development)|go:"GO:0060430"(lung saccule development)|go:"GO:0060509"(type I pneumocyte differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990589"(ATF4-CREB1 transcription factor complex)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001630("cAMP response element binding (CREB) protein")|interpro:IPR003102(Coactivator CBP, pKID)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029802|mint:Q01147|rcsb pdb:1DH3|reactome:R-MMU-198693|reactome:R-MMU-199920|reactome:R-MMU-375165|reactome:R-MMU-442742|reactome:R-MMU-881907|reactome:R-MMU-9031628|reactome:R-MMU-9634638|go:"GO:0010629"(negative regulation of gene expression)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 5A.|antagonist:SB216763 - a GSK-3 inhibitor.|comment:"Transfected exogenous CREB in 293T cells and endogenous CREB in (murine) AML cells transformed by HOXA9/MEIS1 coprecipitated with MEIS1.  GSK-3 inhibitor treatment markedly reduced MEIS1-CREB coimmunoprecipitation, but not interaction of MEIS1 with its dimerization partner PBX1b."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-aml)|taxid:10090("Mus musculus: Acute Myeloid Leukemia cells")	-	2010/06/24	2020/10/21	rogid:X2N9fFxk9ZD7VQHf1oWkxJAtzsc9606	rogid:6UiE0TrylgLe0B/KEEHdAgbFW6g10090	intact-crc:EFA73D765B306996|rigid:2r5/OFsQSJZhs3GvQ1fUbF//JdU	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00470	uniprotkb:P16220	intact:EBI-1210694|uniprotkb:A8MV50|ensembl:ENSP00000272369	intact:EBI-711855|uniprotkb:P21934|uniprotkb:Q9UMA7|intact:EBI-28970080|ensembl:ENSP00000236995|ensembl:ENSP00000405539|uniprotkb:Q6V963	psi-mi:meis1_human(display_long)|uniprotkb:MEIS1(gene name)|psi-mi:MEIS1(display_short)	psi-mi:creb1_human(display_long)|uniprotkb:CREB1(gene name)|psi-mi:CREB1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2010)	imex:IM-14346|pubmed:20541704	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2879898|imex:IM-14346-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002389.1|ensembl:ENSG00000143995(gene)|ensembl:ENST00000272369(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001654"(eye development)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR001356(Homeobox)|interpro:IPR008422(Coprinus cinereus mating-type protein)|interpro:IPR009057(Homeodomain-like)|interpro:IPR032453|rcsb pdb:4XRS|rcsb pdb:5EGO|reactome:R-HSA-5617472	go:"GO:0000791"(euchromatin)|ensembl:ENSG00000118260(gene)|ensembl:ENST00000353267(transcript)|ensembl:ENST00000430624(transcript)|go:"GO:0000785"(chromatin)|ensembl:ENSP00000236995|ensembl:ENSP00000405539|ensembl:ENST00000432329|ensembl:ENSP00000387699|refseq:NP_004370.1|refseq:NP_604391.1|refseq:XP_011508947.1|dip:DIP-765N|refseq:XP_011508949.1|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007568"(aging)|go:"GO:0007595"(lactation)|go:"GO:0007613"(memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008542"(visual learning)|go:"GO:0010033"(response to organic substance)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0014823"(response to activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030424"(axon)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032916"(positive regulation of transforming growth factor beta3 production)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033762"(response to glucagon)|go:"GO:0034670"(chemotaxis to arachidonic acid)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035094"(response to nicotine)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0055025"(positive regulation of cardiac muscle tissue development)|go:"GO:0060251"(regulation of glial cell proliferation)|go:"GO:0060430"(lung saccule development)|go:"GO:0060509"(type I pneumocyte differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990589"(ATF4-CREB1 transcription factor complex)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001630("cAMP response element binding (CREB) protein")|interpro:IPR003102(Coactivator CBP, pKID)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029802|mint:P16220|rcsb pdb:2LXT|rcsb pdb:5ZK1|rcsb pdb:5ZKO|reactome:R-HSA-111931|reactome:R-HSA-111932|reactome:R-HSA-198693|reactome:R-HSA-199920|reactome:R-HSA-2151201|reactome:R-HSA-2197563|reactome:R-HSA-375165|reactome:R-HSA-400253|reactome:R-HSA-442720|reactome:R-HSA-442729|reactome:R-HSA-442742|reactome:R-HSA-5674400|reactome:R-HSA-881907|reactome:R-HSA-9022692|reactome:R-HSA-9022699|reactome:R-HSA-9022702|reactome:R-HSA-9022707|reactome:R-HSA-9031628|reactome:R-HSA-9609690|reactome:R-HSA-9616222|reactome:R-HSA-9634638|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-9707616	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 5A.|antagonist:SB216763 - a GSK-3 inhibitor.|comment:"Transfected exogenous CREB in 293T cells and endogenous CREB in (murine) AML cells transformed by HOXA9/MEIS1 coprecipitated with MEIS1.  GSK-3 inhibitor treatment markedly reduced MEIS1-CREB coimmunoprecipitation, but not interaction of MEIS1 with its dimerization partner PBX1b."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-aml)|taxid:10090("Mus musculus: Acute Myeloid Leukemia cells")	-	2010/06/24	2020/10/21	rogid:X2N9fFxk9ZD7VQHf1oWkxJAtzsc9606	rogid:+gDlECcpJ4ma+wfUc19mIXyACKU9606	intact-crc:EFA73D765B306996|rigid:2r5/OFsQSJZhs3GvQ1fUbF//JdU	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O00470	uniprotkb:P16220	intact:EBI-1210694|uniprotkb:A8MV50|ensembl:ENSP00000272369	intact:EBI-711855|uniprotkb:P21934|uniprotkb:Q9UMA7|intact:EBI-28970080|ensembl:ENSP00000236995|ensembl:ENSP00000405539|uniprotkb:Q6V963	psi-mi:meis1_human(display_long)|uniprotkb:MEIS1(gene name)|psi-mi:MEIS1(display_short)	psi-mi:creb1_human(display_long)|uniprotkb:CREB1(gene name)|psi-mi:CREB1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2010)	imex:IM-14346|pubmed:20541704	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2879928|imex:IM-14346-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002389.1|ensembl:ENSG00000143995(gene)|ensembl:ENST00000272369(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001654"(eye development)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR001356(Homeobox)|interpro:IPR008422(Coprinus cinereus mating-type protein)|interpro:IPR009057(Homeodomain-like)|interpro:IPR032453|rcsb pdb:4XRS|rcsb pdb:5EGO|reactome:R-HSA-5617472	go:"GO:0000791"(euchromatin)|ensembl:ENSG00000118260(gene)|ensembl:ENST00000353267(transcript)|ensembl:ENST00000430624(transcript)|go:"GO:0000785"(chromatin)|ensembl:ENSP00000236995|ensembl:ENSP00000405539|ensembl:ENST00000432329|ensembl:ENSP00000387699|refseq:NP_004370.1|refseq:NP_604391.1|refseq:XP_011508947.1|dip:DIP-765N|refseq:XP_011508949.1|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007568"(aging)|go:"GO:0007595"(lactation)|go:"GO:0007613"(memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008542"(visual learning)|go:"GO:0010033"(response to organic substance)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0014823"(response to activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030424"(axon)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032916"(positive regulation of transforming growth factor beta3 production)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033762"(response to glucagon)|go:"GO:0034670"(chemotaxis to arachidonic acid)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035094"(response to nicotine)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0055025"(positive regulation of cardiac muscle tissue development)|go:"GO:0060251"(regulation of glial cell proliferation)|go:"GO:0060430"(lung saccule development)|go:"GO:0060509"(type I pneumocyte differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990589"(ATF4-CREB1 transcription factor complex)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001630("cAMP response element binding (CREB) protein")|interpro:IPR003102(Coactivator CBP, pKID)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029802|mint:P16220|rcsb pdb:2LXT|rcsb pdb:5ZK1|rcsb pdb:5ZKO|reactome:R-HSA-111931|reactome:R-HSA-111932|reactome:R-HSA-198693|reactome:R-HSA-199920|reactome:R-HSA-2151201|reactome:R-HSA-2197563|reactome:R-HSA-375165|reactome:R-HSA-400253|reactome:R-HSA-442720|reactome:R-HSA-442729|reactome:R-HSA-442742|reactome:R-HSA-5674400|reactome:R-HSA-881907|reactome:R-HSA-9022692|reactome:R-HSA-9022699|reactome:R-HSA-9022702|reactome:R-HSA-9022707|reactome:R-HSA-9031628|reactome:R-HSA-9609690|reactome:R-HSA-9616222|reactome:R-HSA-9634638|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-9707616	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 5B.|antagonist:SB216763 - a GSK-3 inhibitor.|comment:GSK3-dependent association of endogenous CREB and MEIS1 was observed in coprecipitation studies of the human MLL leukemia cell line MV411.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mv4-11)|taxid:9606(Human MV4-11, Acute Monocytic Leukemia cell line)	-	2010/06/24	2020/10/21	rogid:X2N9fFxk9ZD7VQHf1oWkxJAtzsc9606	rogid:+gDlECcpJ4ma+wfUc19mIXyACKU9606	intact-crc:274F74E5B6BD24E5|rigid:7GxkeDge9ZJGXRXeSRWDWOHKGfQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16220	uniprotkb:O00470	intact:EBI-711855|uniprotkb:P21934|uniprotkb:Q9UMA7|intact:EBI-28970080|ensembl:ENSP00000236995|ensembl:ENSP00000405539|uniprotkb:Q6V963	intact:EBI-1210694|uniprotkb:A8MV50|ensembl:ENSP00000272369	psi-mi:creb1_human(display_long)|uniprotkb:CREB1(gene name)|psi-mi:CREB1(display_short)	psi-mi:meis1_human(display_long)|uniprotkb:MEIS1(gene name)|psi-mi:MEIS1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2010)	imex:IM-14346|pubmed:20541704	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2879952|imex:IM-14346-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000791"(euchromatin)|ensembl:ENSG00000118260(gene)|ensembl:ENST00000353267(transcript)|ensembl:ENST00000430624(transcript)|go:"GO:0000785"(chromatin)|ensembl:ENSP00000236995|ensembl:ENSP00000405539|ensembl:ENST00000432329|ensembl:ENSP00000387699|refseq:NP_004370.1|refseq:NP_604391.1|refseq:XP_011508947.1|dip:DIP-765N|refseq:XP_011508949.1|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007568"(aging)|go:"GO:0007595"(lactation)|go:"GO:0007613"(memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008542"(visual learning)|go:"GO:0010033"(response to organic substance)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0014823"(response to activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030424"(axon)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032916"(positive regulation of transforming growth factor beta3 production)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033762"(response to glucagon)|go:"GO:0034670"(chemotaxis to arachidonic acid)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035094"(response to nicotine)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0055025"(positive regulation of cardiac muscle tissue development)|go:"GO:0060251"(regulation of glial cell proliferation)|go:"GO:0060430"(lung saccule development)|go:"GO:0060509"(type I pneumocyte differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990589"(ATF4-CREB1 transcription factor complex)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001630("cAMP response element binding (CREB) protein")|interpro:IPR003102(Coactivator CBP, pKID)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029802|mint:P16220|rcsb pdb:2LXT|rcsb pdb:5ZK1|rcsb pdb:5ZKO|reactome:R-HSA-111931|reactome:R-HSA-111932|reactome:R-HSA-198693|reactome:R-HSA-199920|reactome:R-HSA-2151201|reactome:R-HSA-2197563|reactome:R-HSA-375165|reactome:R-HSA-400253|reactome:R-HSA-442720|reactome:R-HSA-442729|reactome:R-HSA-442742|reactome:R-HSA-5674400|reactome:R-HSA-881907|reactome:R-HSA-9022692|reactome:R-HSA-9022699|reactome:R-HSA-9022702|reactome:R-HSA-9022707|reactome:R-HSA-9031628|reactome:R-HSA-9609690|reactome:R-HSA-9616222|reactome:R-HSA-9634638|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-9707616	refseq:NP_002389.1|ensembl:ENSG00000143995(gene)|ensembl:ENST00000272369(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001654"(eye development)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR001356(Homeobox)|interpro:IPR008422(Coprinus cinereus mating-type protein)|interpro:IPR009057(Homeodomain-like)|interpro:IPR032453|rcsb pdb:4XRS|rcsb pdb:5EGO|reactome:R-HSA-5617472	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 5C.|antagonist:SB216763 - a GSK-3 inhibitor.|comment:Transfected exogenous CREB in 293T cells coprecipitated with MEIS1, but  CREB mutants S129A and S133A did not coimmunoprecipitate with MEIS1.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/06/24	2020/10/21	rogid:+gDlECcpJ4ma+wfUc19mIXyACKU9606	rogid:X2N9fFxk9ZD7VQHf1oWkxJAtzsc9606	intact-crc:E2278C776488001F|rigid:7GxkeDge9ZJGXRXeSRWDWOHKGfQ	false	flag tag:?-?|mutation decreasing interaction:115-115|mutation decreasing interaction:119-119	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O00470	uniprotkb:Q6UUV9	intact:EBI-1210694|uniprotkb:A8MV50|ensembl:ENSP00000272369	intact:EBI-1644259|uniprotkb:A6NMG5|uniprotkb:O75114|uniprotkb:Q6Y3A3|uniprotkb:Q7LDZ2|uniprotkb:Q8IUL3|uniprotkb:Q8IZ34|uniprotkb:Q8IZL1|uniprotkb:Q8N6W3|uniprotkb:Q96AI8|uniprotkb:Q9H801|ensembl:ENSP00000323332	psi-mi:meis1_human(display_long)|uniprotkb:MEIS1(gene name)|psi-mi:MEIS1(display_short)	psi-mi:crtc1_human(display_long)|uniprotkb:CRTC1(gene name)|psi-mi:CRTC1(display_short)|uniprotkb:KIAA0616(gene name synonym)|uniprotkb:MECT1(gene name synonym)|uniprotkb:TORC1(gene name synonym)|uniprotkb:WAMTP1(gene name synonym)|uniprotkb:Transducer of regulated cAMP response element-binding protein 1(gene name synonym)|uniprotkb:Mucoepidermoid carcinoma translocated protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2010)	imex:IM-14346|pubmed:20541704	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2879998|imex:IM-14346-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002389.1|ensembl:ENSG00000143995(gene)|ensembl:ENST00000272369(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001654"(eye development)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR001356(Homeobox)|interpro:IPR008422(Coprinus cinereus mating-type protein)|interpro:IPR009057(Homeodomain-like)|interpro:IPR032453|rcsb pdb:4XRS|rcsb pdb:5EGO|reactome:R-HSA-5617472	refseq:NP_001091952.1|refseq:NP_056136.2|ensembl:ENSG00000105662(gene)|ensembl:ENST00000321949(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007613"(memory)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016604"(nuclear body)|go:"GO:0030425"(dendrite)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1902631"(negative regulation of membrane hyperpolarization)|interpro:IPR024783|interpro:IPR024784|interpro:IPR024785|interpro:IPR024786|rcsb pdb:7D8H|rcsb pdb:7D8P|rcsb pdb:7D9V|reactome:R-HSA-2151201|reactome:R-HSA-400253|reactome:R-HSA-9707616	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 5E.|antagonist:SB216763 - a GSK-3 inhibitor.|comment:MEIS1 also coprecipitated the CREB coactivators CBP and TORC, which was markedly reduced by GSK-3 inhibition.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/06/24	2020/10/21	rogid:X2N9fFxk9ZD7VQHf1oWkxJAtzsc9606	rogid:9CSi8BoJZJGZUiXqKRyO6947oL09606	intact-crc:492E13AC9CA530BA|rigid:WvVlmGPNh2TAXpk2/MSSVKwgCe8	false	ha tag:?-?	v5 tag:?-?|his tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O00470	uniprotkb:P16220	intact:EBI-1210694|uniprotkb:A8MV50|ensembl:ENSP00000272369	intact:EBI-711855|uniprotkb:P21934|uniprotkb:Q9UMA7|intact:EBI-28970080|ensembl:ENSP00000236995|ensembl:ENSP00000405539|uniprotkb:Q6V963	psi-mi:meis1_human(display_long)|uniprotkb:MEIS1(gene name)|psi-mi:MEIS1(display_short)	psi-mi:creb1_human(display_long)|uniprotkb:CREB1(gene name)|psi-mi:CREB1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2010)	imex:IM-14346|pubmed:20541704	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2879998|imex:IM-14346-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002389.1|ensembl:ENSG00000143995(gene)|ensembl:ENST00000272369(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001654"(eye development)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR001356(Homeobox)|interpro:IPR008422(Coprinus cinereus mating-type protein)|interpro:IPR009057(Homeodomain-like)|interpro:IPR032453|rcsb pdb:4XRS|rcsb pdb:5EGO|reactome:R-HSA-5617472	go:"GO:0000791"(euchromatin)|ensembl:ENSG00000118260(gene)|ensembl:ENST00000353267(transcript)|ensembl:ENST00000430624(transcript)|go:"GO:0000785"(chromatin)|ensembl:ENSP00000236995|ensembl:ENSP00000405539|ensembl:ENST00000432329|ensembl:ENSP00000387699|refseq:NP_004370.1|refseq:NP_604391.1|refseq:XP_011508947.1|dip:DIP-765N|refseq:XP_011508949.1|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007568"(aging)|go:"GO:0007595"(lactation)|go:"GO:0007613"(memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008542"(visual learning)|go:"GO:0010033"(response to organic substance)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0014823"(response to activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030424"(axon)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032916"(positive regulation of transforming growth factor beta3 production)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033762"(response to glucagon)|go:"GO:0034670"(chemotaxis to arachidonic acid)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035094"(response to nicotine)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0055025"(positive regulation of cardiac muscle tissue development)|go:"GO:0060251"(regulation of glial cell proliferation)|go:"GO:0060430"(lung saccule development)|go:"GO:0060509"(type I pneumocyte differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990589"(ATF4-CREB1 transcription factor complex)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001630("cAMP response element binding (CREB) protein")|interpro:IPR003102(Coactivator CBP, pKID)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029802|mint:P16220|rcsb pdb:2LXT|rcsb pdb:5ZK1|rcsb pdb:5ZKO|reactome:R-HSA-111931|reactome:R-HSA-111932|reactome:R-HSA-198693|reactome:R-HSA-199920|reactome:R-HSA-2151201|reactome:R-HSA-2197563|reactome:R-HSA-375165|reactome:R-HSA-400253|reactome:R-HSA-442720|reactome:R-HSA-442729|reactome:R-HSA-442742|reactome:R-HSA-5674400|reactome:R-HSA-881907|reactome:R-HSA-9022692|reactome:R-HSA-9022699|reactome:R-HSA-9022702|reactome:R-HSA-9022707|reactome:R-HSA-9031628|reactome:R-HSA-9609690|reactome:R-HSA-9616222|reactome:R-HSA-9634638|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-9707616	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 5E.|antagonist:SB216763 - a GSK-3 inhibitor.|comment:MEIS1 also coprecipitated the CREB coactivators CBP and TORC, which was markedly reduced by GSK-3 inhibition.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/06/24	2020/10/21	rogid:X2N9fFxk9ZD7VQHf1oWkxJAtzsc9606	rogid:+gDlECcpJ4ma+wfUc19mIXyACKU9606	intact-crc:492E13AC9CA530BA|rigid:WvVlmGPNh2TAXpk2/MSSVKwgCe8	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P16220	uniprotkb:O00470	intact:EBI-711855|uniprotkb:P21934|uniprotkb:Q9UMA7|intact:EBI-28970080|ensembl:ENSP00000236995|ensembl:ENSP00000405539|uniprotkb:Q6V963	intact:EBI-1210694|uniprotkb:A8MV50|ensembl:ENSP00000272369	psi-mi:creb1_human(display_long)|uniprotkb:CREB1(gene name)|psi-mi:CREB1(display_short)	psi-mi:meis1_human(display_long)|uniprotkb:MEIS1(gene name)|psi-mi:MEIS1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2010)	imex:IM-14346|pubmed:20541704	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2889326|imex:IM-14346-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000791"(euchromatin)|ensembl:ENSG00000118260(gene)|ensembl:ENST00000353267(transcript)|ensembl:ENST00000430624(transcript)|go:"GO:0000785"(chromatin)|ensembl:ENSP00000236995|ensembl:ENSP00000405539|ensembl:ENST00000432329|ensembl:ENSP00000387699|refseq:NP_004370.1|refseq:NP_604391.1|refseq:XP_011508947.1|dip:DIP-765N|refseq:XP_011508949.1|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007568"(aging)|go:"GO:0007595"(lactation)|go:"GO:0007613"(memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008542"(visual learning)|go:"GO:0010033"(response to organic substance)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0014823"(response to activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030424"(axon)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032916"(positive regulation of transforming growth factor beta3 production)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033762"(response to glucagon)|go:"GO:0034670"(chemotaxis to arachidonic acid)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035094"(response to nicotine)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0055025"(positive regulation of cardiac muscle tissue development)|go:"GO:0060251"(regulation of glial cell proliferation)|go:"GO:0060430"(lung saccule development)|go:"GO:0060509"(type I pneumocyte differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990589"(ATF4-CREB1 transcription factor complex)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001630("cAMP response element binding (CREB) protein")|interpro:IPR003102(Coactivator CBP, pKID)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029802|mint:P16220|rcsb pdb:2LXT|rcsb pdb:5ZK1|rcsb pdb:5ZKO|reactome:R-HSA-111931|reactome:R-HSA-111932|reactome:R-HSA-198693|reactome:R-HSA-199920|reactome:R-HSA-2151201|reactome:R-HSA-2197563|reactome:R-HSA-375165|reactome:R-HSA-400253|reactome:R-HSA-442720|reactome:R-HSA-442729|reactome:R-HSA-442742|reactome:R-HSA-5674400|reactome:R-HSA-881907|reactome:R-HSA-9022692|reactome:R-HSA-9022699|reactome:R-HSA-9022702|reactome:R-HSA-9022707|reactome:R-HSA-9031628|reactome:R-HSA-9609690|reactome:R-HSA-9616222|reactome:R-HSA-9634638|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-9707616	refseq:NP_002389.1|ensembl:ENSG00000143995(gene)|ensembl:ENST00000272369(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001654"(eye development)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR001356(Homeobox)|interpro:IPR008422(Coprinus cinereus mating-type protein)|interpro:IPR009057(Homeodomain-like)|interpro:IPR032453|rcsb pdb:4XRS|rcsb pdb:5EGO|reactome:R-HSA-5617472	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig 5I.|comment:Deletion of the MEIS1 C terminus  abrogates MEIS1 transcriptional activation and association with CREB.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/06/24	2020/10/21	rogid:+gDlECcpJ4ma+wfUc19mIXyACKU9606	rogid:X2N9fFxk9ZD7VQHf1oWkxJAtzsc9606	intact-crc:BB101FAF496F877A|rigid:7GxkeDge9ZJGXRXeSRWDWOHKGfQ	false	flag tag:?-?	ha tag:?-?|necessary binding region:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
ensembl:ENSMUSG00000021250	uniprotkb:P16220	intact:EBI-2889367	intact:EBI-711855|uniprotkb:P21934|uniprotkb:Q9UMA7|intact:EBI-28970080|ensembl:ENSP00000236995|ensembl:ENSP00000405539|uniprotkb:Q6V963	psi-mi:fos_mouse_gene(display_short)|psi-mi:ENSMUSG00000021250(display_long)	psi-mi:creb1_human(display_long)|uniprotkb:CREB1(gene name)|psi-mi:CREB1(display_short)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Wang et al. (2010)	imex:IM-14346|pubmed:20541704	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2889356|imex:IM-14346-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	go:"GO:0000791"(euchromatin)|ensembl:ENSG00000118260(gene)|ensembl:ENST00000353267(transcript)|ensembl:ENST00000430624(transcript)|go:"GO:0000785"(chromatin)|ensembl:ENSP00000236995|ensembl:ENSP00000405539|ensembl:ENST00000432329|ensembl:ENSP00000387699|refseq:NP_004370.1|refseq:NP_604391.1|refseq:XP_011508947.1|dip:DIP-765N|refseq:XP_011508949.1|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007568"(aging)|go:"GO:0007595"(lactation)|go:"GO:0007613"(memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008361"(regulation of cell size)|go:"GO:0008542"(visual learning)|go:"GO:0010033"(response to organic substance)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0014823"(response to activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030424"(axon)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032916"(positive regulation of transforming growth factor beta3 production)|go:"GO:0033363"(secretory granule organization)|go:"GO:0033762"(response to glucagon)|go:"GO:0034670"(chemotaxis to arachidonic acid)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035094"(response to nicotine)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0055025"(positive regulation of cardiac muscle tissue development)|go:"GO:0060251"(regulation of glial cell proliferation)|go:"GO:0060430"(lung saccule development)|go:"GO:0060509"(type I pneumocyte differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990589"(ATF4-CREB1 transcription factor complex)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001630("cAMP response element binding (CREB) protein")|interpro:IPR003102(Coactivator CBP, pKID)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029802|mint:P16220|rcsb pdb:2LXT|rcsb pdb:5ZK1|rcsb pdb:5ZKO|reactome:R-HSA-111931|reactome:R-HSA-111932|reactome:R-HSA-198693|reactome:R-HSA-199920|reactome:R-HSA-2151201|reactome:R-HSA-2197563|reactome:R-HSA-375165|reactome:R-HSA-400253|reactome:R-HSA-442720|reactome:R-HSA-442729|reactome:R-HSA-442742|reactome:R-HSA-5674400|reactome:R-HSA-881907|reactome:R-HSA-9022692|reactome:R-HSA-9022699|reactome:R-HSA-9022702|reactome:R-HSA-9022707|reactome:R-HSA-9031628|reactome:R-HSA-9609690|reactome:R-HSA-9616222|reactome:R-HSA-9634638|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-9707616	-	-	-	figure legend:Fig 6D.|antagonist:SB216763 - a GSK-3 inhibitor.|comment:In HOXA9/MEIS1 transformed myeloid progenitors, chromatin IP of the FOS promoter showed MEIS1 and CREB occupancy, which was reduced by GSK-3 inhibition.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-myeloid_progenitors)|taxid:10090(Mouse myeloid progenitor cells)	-	2010/06/24	2020/10/21	-	rogid:+gDlECcpJ4ma+wfUc19mIXyACKU9606	intact-crc:4DD7B9904FF30361	false	-	-	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
uniprotkb:O00470	ensembl:ENSMUSG00000021250	intact:EBI-1210694|uniprotkb:A8MV50|ensembl:ENSP00000272369	intact:EBI-2889367	psi-mi:meis1_human(display_long)|uniprotkb:MEIS1(gene name)|psi-mi:MEIS1(display_short)	psi-mi:fos_mouse_gene(display_short)|psi-mi:ENSMUSG00000021250(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Wang et al. (2010)	imex:IM-14346|pubmed:20541704	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2889370|imex:IM-14346-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_002389.1|ensembl:ENSG00000143995(gene)|ensembl:ENST00000272369(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001654"(eye development)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR001356(Homeobox)|interpro:IPR008422(Coprinus cinereus mating-type protein)|interpro:IPR009057(Homeodomain-like)|interpro:IPR032453|rcsb pdb:4XRS|rcsb pdb:5EGO|reactome:R-HSA-5617472	-	-	-	-	figure legend:Fig 6D.|antagonist:SB216763 - a GSK-3 inhibitor.|comment:In HOXA9/MEIS1 transformed myeloid progenitors, chromatin IP of the FOS promoter showed MEIS1 and CREB occupancy, which was reduced by GSK-3 inhibition.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-myeloid_progenitors)|taxid:10090(Mouse myeloid progenitor cells)	-	2010/06/24	2014/10/16	rogid:X2N9fFxk9ZD7VQHf1oWkxJAtzsc9606	-	intact-crc:DFCE5BBFC5078E0A	false	ha tag:?-?	-	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)