#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P42785	uniprotkb:O60883	intact:EBI-2803892|uniprotkb:B5BU34|uniprotkb:B2R7B7|ensembl:ENSP00000317362|uniprotkb:A8MU24|uniprotkb:B3KRK5	intact:EBI-2927498|ensembl:ENSP00000356251|uniprotkb:Q5SXP7|uniprotkb:Q86VP7|uniprotkb:B2R7M9	psi-mi:pcp_human(display_long)|uniprotkb:PRCP(gene name)|psi-mi:PRCP(display_short)|uniprotkb:PCP(gene name synonym)|uniprotkb:Prolylcarboxypeptidase(gene name synonym)|uniprotkb:Proline carboxypeptidase(gene name synonym)|uniprotkb:Angiotensinase C(gene name synonym)|uniprotkb:Lysosomal carboxypeptidase C(gene name synonym)	psi-mi:g37l1_human(display_long)|uniprotkb:GPR37L1(gene name)|psi-mi:GPR37L1(display_short)|uniprotkb:ETBRLP2(gene name synonym)|uniprotkb:Endothelin B receptor-like protein 2(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Zhao et al. (2010)	imex:IM-15129|pubmed:20517885	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2927529|imex:IM-15129-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005031.1|refseq:NP_955450.2|ensembl:ENSG00000137509(gene)|ensembl:ENST00000313010(transcript)|go:"GO:0002155"(regulation of thyroid hormone mediated signaling pathway)|go:"GO:0002353"(plasma kallikrein-kinin cascade)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0004185"(serine-type carboxypeptidase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0045178"(basal part of cell)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097009"(energy homeostasis)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR008758(Peptidase S28)|interpro:IPR029058|rcsb pdb:3N2Z|reactome:R-HSA-140837|reactome:R-HSA-6798695|interpro:IPR042269|refseq:NP_001306143.1	go:"GO:0060170"(ciliary membrane)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003909(GPR37 orphan receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-375276|reactome:R-HSA-418594|go:"GO:0048712"(negative regulation of astrocyte differentiation)|ensembl:ENSG00000170075(gene)|ensembl:ENST00000367282(transcript)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|go:"GO:0036505"(prosaposin receptor activity)|go:"GO:0042277"(peptide binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|refseq:NP_004758.3	go:"GO:0004185"(serine-type carboxypeptidase activity)	-	-	figure legend:Fig 2.|comment:Stable isotope-labeled Angiotensin III peptide was added as a positive control.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/15	2014/10/16	rogid:R4c0aA6kCFSSBI6jvzdbfoXNHIo9606	rogid:dA1wkFUyot4DrxH+xJhgSjO/gVE9606	intact-crc:05A0E6E236778AB1|rigid:47m6t4ihCnlNXboROOo5rhfvfBY	false	his tag:?-?|sufficient binding region:46-496	identified peptide:67-74	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P42785	uniprotkb:P01019-PRO_0000032459	intact:EBI-2803892|uniprotkb:B5BU34|uniprotkb:B2R7B7|ensembl:ENSP00000317362|uniprotkb:A8MU24|uniprotkb:B3KRK5	intact:EBI-2927577	psi-mi:pcp_human(display_long)|uniprotkb:PRCP(gene name)|psi-mi:PRCP(display_short)|uniprotkb:PCP(gene name synonym)|uniprotkb:Prolylcarboxypeptidase(gene name synonym)|uniprotkb:Proline carboxypeptidase(gene name synonym)|uniprotkb:Angiotensinase C(gene name synonym)|uniprotkb:Lysosomal carboxypeptidase C(gene name synonym)	psi-mi:p01019-pro_0000032459(display_long)|uniprotkb:AGT(gene name)|psi-mi:AGT(display_short)|uniprotkb:SERPINA8(gene name synonym)|uniprotkb:Serpin A8(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Zhao et al. (2010)	imex:IM-15129|pubmed:20517885	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2939543|imex:IM-15129-2	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005031.1|refseq:NP_955450.2|ensembl:ENSG00000137509(gene)|ensembl:ENST00000313010(transcript)|go:"GO:0002155"(regulation of thyroid hormone mediated signaling pathway)|go:"GO:0002353"(plasma kallikrein-kinin cascade)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0004185"(serine-type carboxypeptidase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0045178"(basal part of cell)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097009"(energy homeostasis)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR008758(Peptidase S28)|interpro:IPR029058|rcsb pdb:3N2Z|reactome:R-HSA-140837|reactome:R-HSA-6798695|interpro:IPR042269|refseq:NP_001306143.1	intact:EBI-751728(chain-parent)	go:"GO:0004185"(serine-type carboxypeptidase activity)	-	chain-seq-start:35|chain-seq-end:41	figure legend:Fig 2.|comment:Stable isotope-labeled Angiotensin III peptide was added as a positive control.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/15	2014/10/16	rogid:R4c0aA6kCFSSBI6jvzdbfoXNHIo9606	rogid:bFZEQAk7GJqer1R8daO4K+hXwPQ9606	intact-crc:CAE62AA56E30DB2E|rigid:IS89LqNPHGIiQcLa5wHCIUZC+zU	false	his tag:?-?|sufficient binding region:46-496	15n label:4-4|13c label:4-4	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O60883	uniprotkb:P42785	intact:EBI-2927498|ensembl:ENSP00000356251|uniprotkb:Q5SXP7|uniprotkb:Q86VP7|uniprotkb:B2R7M9	intact:EBI-2803892|uniprotkb:B5BU34|uniprotkb:B2R7B7|ensembl:ENSP00000317362|uniprotkb:A8MU24|uniprotkb:B3KRK5	psi-mi:g37l1_human(display_long)|uniprotkb:GPR37L1(gene name)|psi-mi:GPR37L1(display_short)|uniprotkb:ETBRLP2(gene name synonym)|uniprotkb:Endothelin B receptor-like protein 2(gene name synonym)	psi-mi:pcp_human(display_long)|uniprotkb:PRCP(gene name)|psi-mi:PRCP(display_short)|uniprotkb:PCP(gene name synonym)|uniprotkb:Prolylcarboxypeptidase(gene name synonym)|uniprotkb:Proline carboxypeptidase(gene name synonym)|uniprotkb:Angiotensinase C(gene name synonym)|uniprotkb:Lysosomal carboxypeptidase C(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Zhao et al. (2010)	imex:IM-15129|pubmed:20517885	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2927633|imex:IM-15129-3	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0060170"(ciliary membrane)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003909(GPR37 orphan receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-375276|reactome:R-HSA-418594|go:"GO:0048712"(negative regulation of astrocyte differentiation)|ensembl:ENSG00000170075(gene)|ensembl:ENST00000367282(transcript)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|go:"GO:0036505"(prosaposin receptor activity)|go:"GO:0042277"(peptide binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|refseq:NP_004758.3	refseq:NP_005031.1|refseq:NP_955450.2|ensembl:ENSG00000137509(gene)|ensembl:ENST00000313010(transcript)|go:"GO:0002155"(regulation of thyroid hormone mediated signaling pathway)|go:"GO:0002353"(plasma kallikrein-kinin cascade)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0004185"(serine-type carboxypeptidase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0045178"(basal part of cell)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097009"(energy homeostasis)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR008758(Peptidase S28)|interpro:IPR029058|rcsb pdb:3N2Z|reactome:R-HSA-140837|reactome:R-HSA-6798695|interpro:IPR042269|refseq:NP_001306143.1	go:"GO:0004185"(serine-type carboxypeptidase activity)	-	-	figure legend:Fig 2D.|kinetics:"The apparent second-order rate constant  kcat/KM for PRCP-mediated cleavage was determined to be 2.1E-5 (s-1M-1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/09/15	2014/10/16	rogid:dA1wkFUyot4DrxH+xJhgSjO/gVE9606	rogid:R4c0aA6kCFSSBI6jvzdbfoXNHIo9606	intact-crc:81807D4A8798B7EB|rigid:47m6t4ihCnlNXboROOo5rhfvfBY	false	sufficient binding region:67-74	his tag:?-?|sufficient binding region:46-496	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)