#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P18910	uniprotkb:P20020	intact:EBI-7945470|uniprotkb:A1A5N8|intact:UNK-5360342|ensembl:ENSRNOP00000020307	intact:EBI-5279998|uniprotkb:Q12992|uniprotkb:Q12993|uniprotkb:Q13819|uniprotkb:Q13820|uniprotkb:Q13821|uniprotkb:Q16504|uniprotkb:Q93082|ensembl:ENSP00000261173|ensembl:ENSP00000392043	psi-mi:anpra_rat(display_long)|uniprotkb:Atrial natriuretic peptide receptor type A(gene name synonym)|uniprotkb:Guanylate cyclase A(gene name synonym)|uniprotkb:Npr1(gene name)|psi-mi:Npr1(display_short)	psi-mi:at2b1_human(display_long)|uniprotkb:ATP2B1(gene name)|psi-mi:ATP2B1(display_short)|uniprotkb:PMCA1(gene name synonym)|uniprotkb:Plasma membrane calcium ATPase isoform 1(gene name synonym)|uniprotkb:Plasma membrane calcium pump isoform 1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Schröter et al. (2010)	pubmed:20456499|imex:IM-15713|mint:MINT-7713864|mint:fj-10-0082.r1	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7945463|mint:MINT-7713870|imex:IM-15713-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036745.1|rgd:3195|refseq:XP_006232653.1|go:"GO:0006182"(cGMP biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007168"(receptor guanylyl cyclase signaling pathway)|go:"GO:0010753"(positive regulation of cGMP-mediated signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016941"(natriuretic peptide receptor activity)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042562"(hormone binding)|go:"GO:0043235"(receptor complex)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)|interpro:IPR001170(Natriuretic peptide receptor, N-terminal)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR018297|interpro:IPR028082|ensembl:ENSRNOG00000014684(gene)|ensembl:ENSRNOT00000020307(transcript)|go:"GO:0001653"(peptide receptor activity)|go:"GO:0004383"(guanylate cyclase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|rcsb pdb:1DP4|rcsb pdb:1T34|rcsb pdb:3A3K|rcsb pdb:7BRG|rcsb pdb:7BRH|rcsb pdb:7BRI|rcsb pdb:7BRJ|rcsb pdb:7BRK|rcsb pdb:7BRL|reactome:R-RNO-5578768|interpro:IPR029787|mint:MINT-7713872(identity)	refseq:XP_011536709.1|refseq:NP_001001323.1|refseq:NP_001673.2|refseq:XP_016874847.1|reactome:R-HSA-9662360|ensembl:ENSG00000070961(gene)|ensembl:ENST00000261173(transcript)|ensembl:ENST00000428670(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0003407"(neural retina development)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009409"(response to cold)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0034220"(ion transmembrane transport)|interpro:IPR022141|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR030320|interpro:IPR036412|interpro:IPR044492|mint:P20020|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|rcsb pdb:6A69|reactome:R-HSA-418359|reactome:R-HSA-5578775|reactome:R-HSA-936837|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071386"(cellular response to corticosterone stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900076"(regulation of cellular response to insulin stimulus)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905056"(P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:1990034"(calcium ion export across plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|mint:MINT-7713873(identity)	go:"GO:0005886"(plasma membrane)	comment:mint|function:"Receptor for atrial natriuretic peptide (NPPA/ANF). Has guanylate cyclase activity on binding of NPPA/ANF"	-	figure legend:f1c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/03/16	2018/09/18	rogid:9JEcr11NKKmpR8aSLIfXbviexK010116	rogid:kCpUNLYDF38hciXj32D8rXbXULg9606	intact-crc:3406D5FA3FDCFFC1|rigid:Sz2PkOOi+3rbAvbS/wezQ4+6Obw	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P18910	uniprotkb:P20020	intact:EBI-7945470|uniprotkb:A1A5N8|intact:UNK-5360342|ensembl:ENSRNOP00000020307	intact:EBI-5279998|uniprotkb:Q12992|uniprotkb:Q12993|uniprotkb:Q13819|uniprotkb:Q13820|uniprotkb:Q13821|uniprotkb:Q16504|uniprotkb:Q93082|ensembl:ENSP00000261173|ensembl:ENSP00000392043	psi-mi:anpra_rat(display_long)|uniprotkb:Atrial natriuretic peptide receptor type A(gene name synonym)|uniprotkb:Guanylate cyclase A(gene name synonym)|uniprotkb:Npr1(gene name)|psi-mi:Npr1(display_short)	psi-mi:at2b1_human(display_long)|uniprotkb:ATP2B1(gene name)|psi-mi:ATP2B1(display_short)|uniprotkb:PMCA1(gene name synonym)|uniprotkb:Plasma membrane calcium ATPase isoform 1(gene name synonym)|uniprotkb:Plasma membrane calcium pump isoform 1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Schröter et al. (2010)	pubmed:20456499|imex:IM-15713|mint:MINT-7713864|mint:fj-10-0082.r1	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7945535|mint:MINT-7713887|imex:IM-15713-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036745.1|rgd:3195|refseq:XP_006232653.1|go:"GO:0006182"(cGMP biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007168"(receptor guanylyl cyclase signaling pathway)|go:"GO:0010753"(positive regulation of cGMP-mediated signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016941"(natriuretic peptide receptor activity)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042562"(hormone binding)|go:"GO:0043235"(receptor complex)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)|interpro:IPR001170(Natriuretic peptide receptor, N-terminal)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR018297|interpro:IPR028082|ensembl:ENSRNOG00000014684(gene)|ensembl:ENSRNOT00000020307(transcript)|go:"GO:0001653"(peptide receptor activity)|go:"GO:0004383"(guanylate cyclase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|rcsb pdb:1DP4|rcsb pdb:1T34|rcsb pdb:3A3K|rcsb pdb:7BRG|rcsb pdb:7BRH|rcsb pdb:7BRI|rcsb pdb:7BRJ|rcsb pdb:7BRK|rcsb pdb:7BRL|reactome:R-RNO-5578768|interpro:IPR029787|mint:MINT-7713890(identity)	refseq:XP_011536709.1|refseq:NP_001001323.1|refseq:NP_001673.2|refseq:XP_016874847.1|reactome:R-HSA-9662360|ensembl:ENSG00000070961(gene)|ensembl:ENST00000261173(transcript)|ensembl:ENST00000428670(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0003407"(neural retina development)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009409"(response to cold)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0034220"(ion transmembrane transport)|interpro:IPR022141|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR030320|interpro:IPR036412|interpro:IPR044492|mint:P20020|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|rcsb pdb:6A69|reactome:R-HSA-418359|reactome:R-HSA-5578775|reactome:R-HSA-936837|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071386"(cellular response to corticosterone stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900076"(regulation of cellular response to insulin stimulus)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905056"(P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:1990034"(calcium ion export across plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|mint:MINT-7713889(identity)	go:"GO:0005886"(plasma membrane)	comment:mint|function:"Receptor for atrial natriuretic peptide (NPPA/ANF). Has guanylate cyclase activity on binding of NPPA/ANF"	-	figure legend:f1c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/03/16	2018/09/18	rogid:9JEcr11NKKmpR8aSLIfXbviexK010116	rogid:kCpUNLYDF38hciXj32D8rXbXULg9606	intact-crc:C00BC20FBA6AA2B1|rigid:Sz2PkOOi+3rbAvbS/wezQ4+6Obw	false	flag tag:?-?(MINT-7713892)	-	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0422"(immunostaining)