#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O60313	uniprotkb:Q12983	intact:EBI-1054131|uniprotkb:D3DNW4|ensembl:ENSP00000354429|uniprotkb:E5KLJ5|uniprotkb:E5KLJ6|uniprotkb:E5KLJ7|uniprotkb:E5KLK1|uniprotkb:E5KLK2	intact:EBI-749464|uniprotkb:O14620|uniprotkb:Q96GP0|intact:EBI-28978130|ensembl:ENSP00000357625	psi-mi:opa1_human(display_long)|uniprotkb:Optic atrophy protein 1(gene name synonym)|uniprotkb:OPA1(gene name)|psi-mi:OPA1(display_short)|uniprotkb:KIAA0567(gene name synonym)	psi-mi:bnip3_human(display_long)|uniprotkb:BNIP3(gene name)|psi-mi:BNIP3(display_short)|uniprotkb:NIP3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Landes et al. (2010)	pubmed:20436456|imex:IM-15080|mint:MINT-7906780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-5261035|imex:IM-15080-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056375.2|ensembl:ENSG00000198836(gene)|ensembl:ENST00000361828(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0007601"(visual perception)|go:"GO:0008017"(microtubule binding)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019900"(kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030425"(dendrite)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090102"(cochlea development)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090398"(cellular senescence)|go:"GO:0097749"(membrane tubulation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904643"(response to curcumin)|go:"GO:1905232"(cellular response to L-glutamate)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|interpro:IPR033047|mint:O60313|rcsb pdb:6JTG|reactome:R-HSA-169911|refseq:NP_570844.1|refseq:NP_570846.1|refseq:NP_570847.2|refseq:NP_570850.2|refseq:NP_570849.2	ensembl:ENSP00000357625|refseq:NP_004043.3|dip:DIP-34429N|ensembl:ENSG00000176171(gene)|ensembl:ENST00000368636(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009617"(response to bacterium)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030425"(dendrite)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045837"(negative regulation of membrane potential)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048678"(response to axon injury)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051020"(GTPase binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0051607"(defense response to virus)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071279"(cellular response to cobalt ion)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090649"(response to oxygen-glucose deprivation)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:1902109"(negative regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR010548(BNIP3)|mint:Q12983|rcsb pdb:2J5D|rcsb pdb:2KA1|rcsb pdb:2KA2	-	-	crc64:53967696EDA005E2	figure legend:S1a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/06/18	2017/06/28	rogid:1VmujqR2PEGFIgK9mV+8g57wVb89606	rogid:f+opYD7xO+AbYqLXXC5wh4ZJqIE9606	intact-crc:79A460E6DDCAE1E1|rigid:bCaFux2yxTNeG+C2A1C3FaggsGo	false	sufficient binding region:260-960	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60313	uniprotkb:Q12983	intact:EBI-1054131|uniprotkb:D3DNW4|ensembl:ENSP00000354429|uniprotkb:E5KLJ5|uniprotkb:E5KLJ6|uniprotkb:E5KLJ7|uniprotkb:E5KLK1|uniprotkb:E5KLK2	intact:EBI-749464|uniprotkb:O14620|uniprotkb:Q96GP0|intact:EBI-28978130|ensembl:ENSP00000357625	psi-mi:opa1_human(display_long)|uniprotkb:Optic atrophy protein 1(gene name synonym)|uniprotkb:OPA1(gene name)|psi-mi:OPA1(display_short)|uniprotkb:KIAA0567(gene name synonym)	psi-mi:bnip3_human(display_long)|uniprotkb:BNIP3(gene name)|psi-mi:BNIP3(display_short)|uniprotkb:NIP3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Landes et al. (2010)	pubmed:20436456|imex:IM-15080|mint:MINT-7906780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-5261048|imex:IM-15080-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056375.2|ensembl:ENSG00000198836(gene)|ensembl:ENST00000361828(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0007601"(visual perception)|go:"GO:0008017"(microtubule binding)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019900"(kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030425"(dendrite)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090102"(cochlea development)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090398"(cellular senescence)|go:"GO:0097749"(membrane tubulation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904643"(response to curcumin)|go:"GO:1905232"(cellular response to L-glutamate)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|interpro:IPR033047|mint:O60313|rcsb pdb:6JTG|reactome:R-HSA-169911|refseq:NP_570844.1|refseq:NP_570846.1|refseq:NP_570847.2|refseq:NP_570850.2|refseq:NP_570849.2	ensembl:ENSP00000357625|refseq:NP_004043.3|dip:DIP-34429N|ensembl:ENSG00000176171(gene)|ensembl:ENST00000368636(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009617"(response to bacterium)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030425"(dendrite)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045837"(negative regulation of membrane potential)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048678"(response to axon injury)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051020"(GTPase binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0051607"(defense response to virus)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071279"(cellular response to cobalt ion)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090649"(response to oxygen-glucose deprivation)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:1902109"(negative regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR010548(BNIP3)|mint:Q12983|rcsb pdb:2J5D|rcsb pdb:2KA1|rcsb pdb:2KA2	-	-	crc64:53967696EDA005E2	figure legend:text|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2010/06/18	2017/06/28	rogid:1VmujqR2PEGFIgK9mV+8g57wVb89606	rogid:f+opYD7xO+AbYqLXXC5wh4ZJqIE9606	intact-crc:486070CD8A4459BE|rigid:bCaFux2yxTNeG+C2A1C3FaggsGo	false	sufficient binding region:260-960	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q12983	uniprotkb:O60313	intact:EBI-749464|uniprotkb:O14620|uniprotkb:Q96GP0|intact:EBI-28978130|ensembl:ENSP00000357625	intact:EBI-1054131|uniprotkb:D3DNW4|ensembl:ENSP00000354429|uniprotkb:E5KLJ5|uniprotkb:E5KLJ6|uniprotkb:E5KLJ7|uniprotkb:E5KLK1|uniprotkb:E5KLK2	psi-mi:bnip3_human(display_long)|uniprotkb:BNIP3(gene name)|psi-mi:BNIP3(display_short)|uniprotkb:NIP3(gene name synonym)	psi-mi:opa1_human(display_long)|uniprotkb:Optic atrophy protein 1(gene name synonym)|uniprotkb:OPA1(gene name)|psi-mi:OPA1(display_short)|uniprotkb:KIAA0567(gene name synonym)	psi-mi:"MI:0096"(pull down)	Landes et al. (2010)	pubmed:20436456|imex:IM-15080|mint:MINT-7906780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-5261061|imex:IM-15080-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000357625|refseq:NP_004043.3|dip:DIP-34429N|ensembl:ENSG00000176171(gene)|ensembl:ENST00000368636(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009617"(response to bacterium)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030425"(dendrite)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045837"(negative regulation of membrane potential)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048678"(response to axon injury)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051020"(GTPase binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0051607"(defense response to virus)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071279"(cellular response to cobalt ion)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090649"(response to oxygen-glucose deprivation)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:1902109"(negative regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR010548(BNIP3)|mint:Q12983|rcsb pdb:2J5D|rcsb pdb:2KA1|rcsb pdb:2KA2	refseq:NP_056375.2|ensembl:ENSG00000198836(gene)|ensembl:ENST00000361828(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0007601"(visual perception)|go:"GO:0008017"(microtubule binding)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019900"(kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030425"(dendrite)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090102"(cochlea development)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090398"(cellular senescence)|go:"GO:0097749"(membrane tubulation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904643"(response to curcumin)|go:"GO:1905232"(cellular response to L-glutamate)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|interpro:IPR033047|mint:O60313|rcsb pdb:6JTG|reactome:R-HSA-169911|refseq:NP_570844.1|refseq:NP_570846.1|refseq:NP_570847.2|refseq:NP_570850.2|refseq:NP_570849.2	-	crc64:53967696EDA005E2	-	figure legend:S1b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2017/06/28	rogid:f+opYD7xO+AbYqLXXC5wh4ZJqIE9606	rogid:1VmujqR2PEGFIgK9mV+8g57wVb89606	intact-crc:F690222A44FE8619|rigid:bCaFux2yxTNeG+C2A1C3FaggsGo	false	glutathione s tranferase tag:n-n	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:O60313	uniprotkb:Q12983	intact:EBI-1054131|uniprotkb:D3DNW4|ensembl:ENSP00000354429|uniprotkb:E5KLJ5|uniprotkb:E5KLJ6|uniprotkb:E5KLJ7|uniprotkb:E5KLK1|uniprotkb:E5KLK2	intact:EBI-749464|uniprotkb:O14620|uniprotkb:Q96GP0|intact:EBI-28978130|ensembl:ENSP00000357625	psi-mi:opa1_human(display_long)|uniprotkb:Optic atrophy protein 1(gene name synonym)|uniprotkb:OPA1(gene name)|psi-mi:OPA1(display_short)|uniprotkb:KIAA0567(gene name synonym)	psi-mi:bnip3_human(display_long)|uniprotkb:BNIP3(gene name)|psi-mi:BNIP3(display_short)|uniprotkb:NIP3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Landes et al. (2010)	pubmed:20436456|imex:IM-15080|mint:MINT-7906780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-5261076|imex:IM-15080-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056375.2|ensembl:ENSG00000198836(gene)|ensembl:ENST00000361828(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0007601"(visual perception)|go:"GO:0008017"(microtubule binding)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019900"(kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030425"(dendrite)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090102"(cochlea development)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090398"(cellular senescence)|go:"GO:0097749"(membrane tubulation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904643"(response to curcumin)|go:"GO:1905232"(cellular response to L-glutamate)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|interpro:IPR033047|mint:O60313|rcsb pdb:6JTG|reactome:R-HSA-169911|refseq:NP_570844.1|refseq:NP_570846.1|refseq:NP_570847.2|refseq:NP_570850.2|refseq:NP_570849.2	ensembl:ENSP00000357625|refseq:NP_004043.3|dip:DIP-34429N|ensembl:ENSG00000176171(gene)|ensembl:ENST00000368636(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009617"(response to bacterium)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030425"(dendrite)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045837"(negative regulation of membrane potential)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048678"(response to axon injury)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051020"(GTPase binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0051607"(defense response to virus)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071279"(cellular response to cobalt ion)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090649"(response to oxygen-glucose deprivation)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:1902109"(negative regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR010548(BNIP3)|mint:Q12983|rcsb pdb:2J5D|rcsb pdb:2KA1|rcsb pdb:2KA2	-	-	crc64:53967696EDA005E2	figure legend:S1b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/06/18	2017/06/28	rogid:1VmujqR2PEGFIgK9mV+8g57wVb89606	rogid:f+opYD7xO+AbYqLXXC5wh4ZJqIE9606	intact-crc:E953C5F269619383|rigid:bCaFux2yxTNeG+C2A1C3FaggsGo	false	-	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O60313	uniprotkb:Q12983	intact:EBI-1054131|uniprotkb:D3DNW4|ensembl:ENSP00000354429|uniprotkb:E5KLJ5|uniprotkb:E5KLJ6|uniprotkb:E5KLJ7|uniprotkb:E5KLK1|uniprotkb:E5KLK2	intact:EBI-749464|uniprotkb:O14620|uniprotkb:Q96GP0|intact:EBI-28978130|ensembl:ENSP00000357625	psi-mi:opa1_human(display_long)|uniprotkb:Optic atrophy protein 1(gene name synonym)|uniprotkb:OPA1(gene name)|psi-mi:OPA1(display_short)|uniprotkb:KIAA0567(gene name synonym)	psi-mi:bnip3_human(display_long)|uniprotkb:BNIP3(gene name)|psi-mi:BNIP3(display_short)|uniprotkb:NIP3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Landes et al. (2010)	pubmed:20436456|imex:IM-15080|mint:MINT-7906780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-5261094|imex:IM-15080-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056375.2|ensembl:ENSG00000198836(gene)|ensembl:ENST00000361828(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0007601"(visual perception)|go:"GO:0008017"(microtubule binding)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019900"(kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030425"(dendrite)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090102"(cochlea development)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090398"(cellular senescence)|go:"GO:0097749"(membrane tubulation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904643"(response to curcumin)|go:"GO:1905232"(cellular response to L-glutamate)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|interpro:IPR033047|mint:O60313|rcsb pdb:6JTG|reactome:R-HSA-169911|refseq:NP_570844.1|refseq:NP_570846.1|refseq:NP_570847.2|refseq:NP_570850.2|refseq:NP_570849.2	ensembl:ENSP00000357625|refseq:NP_004043.3|dip:DIP-34429N|ensembl:ENSG00000176171(gene)|ensembl:ENST00000368636(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009617"(response to bacterium)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030425"(dendrite)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045837"(negative regulation of membrane potential)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048678"(response to axon injury)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051020"(GTPase binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0051607"(defense response to virus)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071279"(cellular response to cobalt ion)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090649"(response to oxygen-glucose deprivation)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:1902109"(negative regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR010548(BNIP3)|mint:Q12983|rcsb pdb:2J5D|rcsb pdb:2KA1|rcsb pdb:2KA2	go:"GO:0005739"(mitochondrion)	-	crc64:53967696EDA005E2	figure legend:1a, 1b and S2a left|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2010/06/18	2017/06/28	rogid:1VmujqR2PEGFIgK9mV+8g57wVb89606	rogid:f+opYD7xO+AbYqLXXC5wh4ZJqIE9606	intact-crc:322C0ED47F7F090E|rigid:bCaFux2yxTNeG+C2A1C3FaggsGo	false	-	ha tag:?-?|necessary binding region:229-249	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O60313	uniprotkb:Q12983	intact:EBI-1054131|uniprotkb:D3DNW4|ensembl:ENSP00000354429|uniprotkb:E5KLJ5|uniprotkb:E5KLJ6|uniprotkb:E5KLJ7|uniprotkb:E5KLK1|uniprotkb:E5KLK2	intact:EBI-749464|uniprotkb:O14620|uniprotkb:Q96GP0|intact:EBI-28978130|ensembl:ENSP00000357625	psi-mi:opa1_human(display_long)|uniprotkb:Optic atrophy protein 1(gene name synonym)|uniprotkb:OPA1(gene name)|psi-mi:OPA1(display_short)|uniprotkb:KIAA0567(gene name synonym)	psi-mi:bnip3_human(display_long)|uniprotkb:BNIP3(gene name)|psi-mi:BNIP3(display_short)|uniprotkb:NIP3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Landes et al. (2010)	pubmed:20436456|imex:IM-15080|mint:MINT-7906780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-5261110|imex:IM-15080-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056375.2|ensembl:ENSG00000198836(gene)|ensembl:ENST00000361828(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0007601"(visual perception)|go:"GO:0008017"(microtubule binding)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019900"(kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030425"(dendrite)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090102"(cochlea development)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090398"(cellular senescence)|go:"GO:0097749"(membrane tubulation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904643"(response to curcumin)|go:"GO:1905232"(cellular response to L-glutamate)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|interpro:IPR033047|mint:O60313|rcsb pdb:6JTG|reactome:R-HSA-169911|refseq:NP_570844.1|refseq:NP_570846.1|refseq:NP_570847.2|refseq:NP_570850.2|refseq:NP_570849.2	ensembl:ENSP00000357625|refseq:NP_004043.3|dip:DIP-34429N|ensembl:ENSG00000176171(gene)|ensembl:ENST00000368636(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009617"(response to bacterium)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030425"(dendrite)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045837"(negative regulation of membrane potential)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048678"(response to axon injury)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051020"(GTPase binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0051607"(defense response to virus)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071279"(cellular response to cobalt ion)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090649"(response to oxygen-glucose deprivation)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:1902109"(negative regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR010548(BNIP3)|mint:Q12983|rcsb pdb:2J5D|rcsb pdb:2KA1|rcsb pdb:2KA2	-	-	crc64:53967696EDA005E2	figure legend:S2b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2010/06/18	2017/06/28	rogid:1VmujqR2PEGFIgK9mV+8g57wVb89606	rogid:f+opYD7xO+AbYqLXXC5wh4ZJqIE9606	intact-crc:6D4DCF8C5CC8058B|rigid:bCaFux2yxTNeG+C2A1C3FaggsGo	false	-	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q12983	uniprotkb:O60313	intact:EBI-749464|uniprotkb:O14620|uniprotkb:Q96GP0|intact:EBI-28978130|ensembl:ENSP00000357625	intact:EBI-1054131|uniprotkb:D3DNW4|ensembl:ENSP00000354429|uniprotkb:E5KLJ5|uniprotkb:E5KLJ6|uniprotkb:E5KLJ7|uniprotkb:E5KLK1|uniprotkb:E5KLK2	psi-mi:bnip3_human(display_long)|uniprotkb:BNIP3(gene name)|psi-mi:BNIP3(display_short)|uniprotkb:NIP3(gene name synonym)	psi-mi:opa1_human(display_long)|uniprotkb:Optic atrophy protein 1(gene name synonym)|uniprotkb:OPA1(gene name)|psi-mi:OPA1(display_short)|uniprotkb:KIAA0567(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Landes et al. (2010)	pubmed:20436456|imex:IM-15080|mint:MINT-7906780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-5261140|imex:IM-15080-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000357625|refseq:NP_004043.3|dip:DIP-34429N|ensembl:ENSG00000176171(gene)|ensembl:ENST00000368636(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009617"(response to bacterium)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030425"(dendrite)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045837"(negative regulation of membrane potential)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048678"(response to axon injury)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051020"(GTPase binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0051607"(defense response to virus)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071279"(cellular response to cobalt ion)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090649"(response to oxygen-glucose deprivation)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:1902109"(negative regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR010548(BNIP3)|mint:Q12983|rcsb pdb:2J5D|rcsb pdb:2KA1|rcsb pdb:2KA2	refseq:NP_056375.2|ensembl:ENSG00000198836(gene)|ensembl:ENST00000361828(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0007601"(visual perception)|go:"GO:0008017"(microtubule binding)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019900"(kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030425"(dendrite)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090102"(cochlea development)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090398"(cellular senescence)|go:"GO:0097749"(membrane tubulation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904643"(response to curcumin)|go:"GO:1905232"(cellular response to L-glutamate)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|interpro:IPR033047|mint:O60313|rcsb pdb:6JTG|reactome:R-HSA-169911|refseq:NP_570844.1|refseq:NP_570846.1|refseq:NP_570847.2|refseq:NP_570850.2|refseq:NP_570849.2	go:"GO:0005739"(mitochondrion)	crc64:53967696EDA005E2	-	figure legend:S2c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2010/06/18	2017/06/28	rogid:f+opYD7xO+AbYqLXXC5wh4ZJqIE9606	rogid:1VmujqR2PEGFIgK9mV+8g57wVb89606	intact-crc:AE4863D905F1AB7A|rigid:bCaFux2yxTNeG+C2A1C3FaggsGo	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O60313	uniprotkb:Q12983	intact:EBI-1054131|uniprotkb:D3DNW4|ensembl:ENSP00000354429|uniprotkb:E5KLJ5|uniprotkb:E5KLJ6|uniprotkb:E5KLJ7|uniprotkb:E5KLK1|uniprotkb:E5KLK2	intact:EBI-749464|uniprotkb:O14620|uniprotkb:Q96GP0|intact:EBI-28978130|ensembl:ENSP00000357625	psi-mi:opa1_human(display_long)|uniprotkb:Optic atrophy protein 1(gene name synonym)|uniprotkb:OPA1(gene name)|psi-mi:OPA1(display_short)|uniprotkb:KIAA0567(gene name synonym)	psi-mi:bnip3_human(display_long)|uniprotkb:BNIP3(gene name)|psi-mi:BNIP3(display_short)|uniprotkb:NIP3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Landes et al. (2010)	pubmed:20436456|imex:IM-15080|mint:MINT-7906780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-5261126|imex:IM-15080-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056375.2|ensembl:ENSG00000198836(gene)|ensembl:ENST00000361828(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0007601"(visual perception)|go:"GO:0008017"(microtubule binding)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019900"(kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030425"(dendrite)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090102"(cochlea development)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090398"(cellular senescence)|go:"GO:0097749"(membrane tubulation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904643"(response to curcumin)|go:"GO:1905232"(cellular response to L-glutamate)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|interpro:IPR033047|mint:O60313|rcsb pdb:6JTG|reactome:R-HSA-169911|refseq:NP_570844.1|refseq:NP_570846.1|refseq:NP_570847.2|refseq:NP_570850.2|refseq:NP_570849.2	ensembl:ENSP00000357625|refseq:NP_004043.3|dip:DIP-34429N|ensembl:ENSG00000176171(gene)|ensembl:ENST00000368636(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009617"(response to bacterium)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030425"(dendrite)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045837"(negative regulation of membrane potential)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048678"(response to axon injury)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051020"(GTPase binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0051607"(defense response to virus)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071279"(cellular response to cobalt ion)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090649"(response to oxygen-glucose deprivation)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:1902109"(negative regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR010548(BNIP3)|mint:Q12983|rcsb pdb:2J5D|rcsb pdb:2KA1|rcsb pdb:2KA2	go:"GO:0005739"(mitochondrion)	-	crc64:53967696EDA005E2	figure legend:1a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2010/06/18	2017/06/28	rogid:1VmujqR2PEGFIgK9mV+8g57wVb89606	rogid:f+opYD7xO+AbYqLXXC5wh4ZJqIE9606	intact-crc:4298712C26024AA6|rigid:bCaFux2yxTNeG+C2A1C3FaggsGo	false	-	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O60313	uniprotkb:Q12983	intact:EBI-1054131|uniprotkb:D3DNW4|ensembl:ENSP00000354429|uniprotkb:E5KLJ5|uniprotkb:E5KLJ6|uniprotkb:E5KLJ7|uniprotkb:E5KLK1|uniprotkb:E5KLK2	intact:EBI-749464|uniprotkb:O14620|uniprotkb:Q96GP0|intact:EBI-28978130|ensembl:ENSP00000357625	psi-mi:opa1_human(display_long)|uniprotkb:Optic atrophy protein 1(gene name synonym)|uniprotkb:OPA1(gene name)|psi-mi:OPA1(display_short)|uniprotkb:KIAA0567(gene name synonym)	psi-mi:bnip3_human(display_long)|uniprotkb:BNIP3(gene name)|psi-mi:BNIP3(display_short)|uniprotkb:NIP3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Landes et al. (2010)	pubmed:20436456|imex:IM-15080|mint:MINT-7906780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-5261205|imex:IM-15080-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056375.2|ensembl:ENSG00000198836(gene)|ensembl:ENST00000361828(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0007601"(visual perception)|go:"GO:0008017"(microtubule binding)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019900"(kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030425"(dendrite)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090102"(cochlea development)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090398"(cellular senescence)|go:"GO:0097749"(membrane tubulation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904643"(response to curcumin)|go:"GO:1905232"(cellular response to L-glutamate)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|interpro:IPR033047|mint:O60313|rcsb pdb:6JTG|reactome:R-HSA-169911|refseq:NP_570844.1|refseq:NP_570846.1|refseq:NP_570847.2|refseq:NP_570850.2|refseq:NP_570849.2	ensembl:ENSP00000357625|refseq:NP_004043.3|dip:DIP-34429N|ensembl:ENSG00000176171(gene)|ensembl:ENST00000368636(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009617"(response to bacterium)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030425"(dendrite)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045837"(negative regulation of membrane potential)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048678"(response to axon injury)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051020"(GTPase binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0051607"(defense response to virus)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071279"(cellular response to cobalt ion)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090649"(response to oxygen-glucose deprivation)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:1902109"(negative regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR010548(BNIP3)|mint:Q12983|rcsb pdb:2J5D|rcsb pdb:2KA1|rcsb pdb:2KA2	go:"GO:0005739"(mitochondrion)	-	crc64:53967696EDA005E2	figure legend:S2d|agonist:The interaction requires treatment with CoCl2 to be detected.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2010/06/18	2017/06/28	rogid:1VmujqR2PEGFIgK9mV+8g57wVb89606	rogid:f+opYD7xO+AbYqLXXC5wh4ZJqIE9606	intact-crc:0FCE7018F123D3AE|rigid:bCaFux2yxTNeG+C2A1C3FaggsGo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O60313	uniprotkb:Q12983	intact:EBI-1054131|uniprotkb:D3DNW4|ensembl:ENSP00000354429|uniprotkb:E5KLJ5|uniprotkb:E5KLJ6|uniprotkb:E5KLJ7|uniprotkb:E5KLK1|uniprotkb:E5KLK2	intact:EBI-749464|uniprotkb:O14620|uniprotkb:Q96GP0|intact:EBI-28978130|ensembl:ENSP00000357625	psi-mi:opa1_human(display_long)|uniprotkb:Optic atrophy protein 1(gene name synonym)|uniprotkb:OPA1(gene name)|psi-mi:OPA1(display_short)|uniprotkb:KIAA0567(gene name synonym)	psi-mi:bnip3_human(display_long)|uniprotkb:BNIP3(gene name)|psi-mi:BNIP3(display_short)|uniprotkb:NIP3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Landes et al. (2010)	pubmed:20436456|imex:IM-15080|mint:MINT-7906780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-5261186|imex:IM-15080-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056375.2|ensembl:ENSG00000198836(gene)|ensembl:ENST00000361828(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0007601"(visual perception)|go:"GO:0008017"(microtubule binding)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019900"(kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030425"(dendrite)|go:"GO:0031314"(extrinsic component of mitochondrial inner membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090102"(cochlea development)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090398"(cellular senescence)|go:"GO:0097749"(membrane tubulation)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904643"(response to curcumin)|go:"GO:1905232"(cellular response to L-glutamate)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|interpro:IPR033047|mint:O60313|rcsb pdb:6JTG|reactome:R-HSA-169911|refseq:NP_570844.1|refseq:NP_570846.1|refseq:NP_570847.2|refseq:NP_570850.2|refseq:NP_570849.2	ensembl:ENSP00000357625|refseq:NP_004043.3|dip:DIP-34429N|ensembl:ENSG00000176171(gene)|ensembl:ENST00000368636(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009617"(response to bacterium)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030425"(dendrite)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0035694"(mitochondrial protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045837"(negative regulation of membrane potential)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048678"(response to axon injury)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051020"(GTPase binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0051607"(defense response to virus)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071279"(cellular response to cobalt ion)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090649"(response to oxygen-glucose deprivation)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:1902109"(negative regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR010548(BNIP3)|mint:Q12983|rcsb pdb:2J5D|rcsb pdb:2KA1|rcsb pdb:2KA2	go:"GO:0005739"(mitochondrion)	-	crc64:53967696EDA005E2	figure legend:1c, S2a right and S2d|agonist:The interaction requires hypoxia conditions or treatment with CoCl2 to be detected.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2010/06/18	2017/06/28	rogid:1VmujqR2PEGFIgK9mV+8g57wVb89606	rogid:f+opYD7xO+AbYqLXXC5wh4ZJqIE9606	intact-crc:AAF99796390BE9FB|rigid:bCaFux2yxTNeG+C2A1C3FaggsGo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)