#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P30429-2	uniprotkb:P30429-2	intact:EBI-536271|ensemblmetazoa:C35D10.9a.1|ensemblmetazoa:C35D10.9a.2	intact:EBI-536271|ensemblmetazoa:C35D10.9a.1|ensemblmetazoa:C35D10.9a.2	psi-mi:p30429-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:C35D10.9(orf name)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)	psi-mi:p30429-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:C35D10.9(orf name)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Qi et al. (2010)	imex:IM-14139|pubmed:20434985	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2655126|wwpdb:3LQQ|imex:IM-14139-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-494118(ced4_caeel)|ensemblmetazoa:C35D10.9a.1(transcript)|ensemblmetazoa:C35D10.9a.2(transcript)|ensemblmetazoa:WBGene00000418(gene)	intact:EBI-494118(ced4_caeel)|ensemblmetazoa:C35D10.9a.1(transcript)|ensemblmetazoa:C35D10.9a.2(transcript)|ensemblmetazoa:WBGene00000418(gene)	-	isoform-comment:Major transcript.	isoform-comment:Major transcript.	3d-structure:3.55A|3d-r-factors:Rworking 27.5%, Rfree 31.1%|figure legend:Supp. Table 1|3d-structure:The assembly contains eight molecules of CED-4, arranged as a tetramer of an asymmetric dimer. Each CED-4 contains an ATP molecule and a Mg2+  ion, both buried in the assembly and inaccessible to water molecules.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/05/06	2014/10/16	rogid:sSkgk+GyIaamGk8NHz+MAMUxSQc6239	rogid:sSkgk+GyIaamGk8NHz+MAMUxSQc6239	intact-crc:F4939943C60BE707|rigid:WwVvJC/juTiSnxwD2Urmpw3eMwY	false	-	-	8	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9XYF4-PRO_0000004672	uniprotkb:Q9XYF4-PRO_0000004671	intact:EBI-2655150	intact:EBI-2655147	psi-mi:q9xyf4-pro_0000004672(display_long)|uniprotkb:Dronc(gene name)|psi-mi:Dronc(display_short)|uniprotkb:NEDD2-like caspase(gene name synonym)|uniprotkb:Nc(gene name synonym)|uniprotkb:CG8091(orf name)	psi-mi:q9xyf4-pro_0000004671(display_long)|uniprotkb:Dronc(gene name)|psi-mi:Dronc(display_short)|uniprotkb:NEDD2-like caspase(gene name synonym)|uniprotkb:Nc(gene name synonym)|uniprotkb:CG8091(orf name)	psi-mi:"MI:0071"(molecular sieving)	Qi et al. (2010)	imex:IM-14139|pubmed:20434985	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2655142|imex:IM-14139-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-108311(chain-parent)	intact:EBI-108311(chain-parent)	psi-mi:"MI:0469"(intact)	chain-seq-start:321|chain-seq-end:324	chain-seq-start:135|chain-seq-end:320	figure legend:Supp. Fig. 5C|comment:Expression system of Nc not given.|comment:The two chains of mature Nc form a homodimer.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/05/06	2022/01/18	rogid:0Qdpk9LBk2R5GGdf/va0iDpgpLU7227	rogid:CnqZ78csxmSIPMiVAW/StECRL487227	intact-crc:E0CB26EFA60B1FB4|rigid:f6mYbaJe3XhxZcKQ1s66byWkdAM	false	-	-	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42573	uniprotkb:P42573	intact:EBI-494247|uniprotkb:P45435|uniprotkb:Q9GQQ4|uniprotkb:Q9NAQ8|ensemblmetazoa:C48D1.2a.1	intact:EBI-494247|uniprotkb:P45435|uniprotkb:Q9GQQ4|uniprotkb:Q9NAQ8|ensemblmetazoa:C48D1.2a.1	psi-mi:ced3_caeel(display_long)|uniprotkb:ced-3(gene name)|psi-mi:ced-3(display_short)|uniprotkb:Caspase ced-3(gene name synonym)|uniprotkb:C48D1.2(orf name)	psi-mi:ced3_caeel(display_long)|uniprotkb:ced-3(gene name)|psi-mi:ced-3(display_short)|uniprotkb:Caspase ced-3(gene name synonym)|uniprotkb:C48D1.2(orf name)	psi-mi:"MI:0071"(molecular sieving)	Qi et al. (2010)	imex:IM-14139|pubmed:20434985	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2655158|imex:IM-14139-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001255708.1|wormbase:C48D1.2a|reactome:R-CEL-111465|reactome:R-CEL-198323|reactome:R-CEL-264870|reactome:R-CEL-448706|dip:DIP-244N|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0098793"(presynapse)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905845"(positive regulation of cellular response to gamma radiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:4M9R|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|ensemblmetazoa:C48D1.2a.1(transcript)|ensemblmetazoa:WBGene00000417(gene)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|reactome:R-CEL-140342|reactome:R-CEL-351906|reactome:R-CEL-418889	refseq:NP_001255708.1|wormbase:C48D1.2a|reactome:R-CEL-111465|reactome:R-CEL-198323|reactome:R-CEL-264870|reactome:R-CEL-448706|dip:DIP-244N|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0098793"(presynapse)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905845"(positive regulation of cellular response to gamma radiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:4M9R|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|ensemblmetazoa:C48D1.2a.1(transcript)|ensemblmetazoa:WBGene00000417(gene)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|reactome:R-CEL-140342|reactome:R-CEL-351906|reactome:R-CEL-418889	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 5C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/05/06	2014/10/16	rogid:HFfz1WjirXjAkC5PNlCcB2NqcKE6239	rogid:HFfz1WjirXjAkC5PNlCcB2NqcKE6239	intact-crc:D49A563461A9C92E|rigid:XdL/m8q0PSRI88m3vsFxiYYEGoo	false	sufficient binding region:389-503	sufficient binding region:198-374|mutation:358-358	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42573	uniprotkb:P42573	intact:EBI-494247|uniprotkb:P45435|uniprotkb:Q9GQQ4|uniprotkb:Q9NAQ8|ensemblmetazoa:C48D1.2a.1	intact:EBI-494247|uniprotkb:P45435|uniprotkb:Q9GQQ4|uniprotkb:Q9NAQ8|ensemblmetazoa:C48D1.2a.1	psi-mi:ced3_caeel(display_long)|uniprotkb:ced-3(gene name)|psi-mi:ced-3(display_short)|uniprotkb:Caspase ced-3(gene name synonym)|uniprotkb:C48D1.2(orf name)	psi-mi:ced3_caeel(display_long)|uniprotkb:ced-3(gene name)|psi-mi:ced-3(display_short)|uniprotkb:Caspase ced-3(gene name synonym)|uniprotkb:C48D1.2(orf name)	psi-mi:"MI:0071"(molecular sieving)	Qi et al. (2010)	imex:IM-14139|pubmed:20434985	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2655200|imex:IM-14139-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001255708.1|wormbase:C48D1.2a|reactome:R-CEL-111465|reactome:R-CEL-198323|reactome:R-CEL-264870|reactome:R-CEL-448706|dip:DIP-244N|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0098793"(presynapse)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905845"(positive regulation of cellular response to gamma radiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:4M9R|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|ensemblmetazoa:C48D1.2a.1(transcript)|ensemblmetazoa:WBGene00000417(gene)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|reactome:R-CEL-140342|reactome:R-CEL-351906|reactome:R-CEL-418889	refseq:NP_001255708.1|wormbase:C48D1.2a|reactome:R-CEL-111465|reactome:R-CEL-198323|reactome:R-CEL-264870|reactome:R-CEL-448706|dip:DIP-244N|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0098793"(presynapse)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905845"(positive regulation of cellular response to gamma radiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:4M9R|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|ensemblmetazoa:C48D1.2a.1(transcript)|ensemblmetazoa:WBGene00000417(gene)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|reactome:R-CEL-140342|reactome:R-CEL-351906|reactome:R-CEL-418889	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 5D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/05/06	2014/10/16	rogid:HFfz1WjirXjAkC5PNlCcB2NqcKE6239	rogid:HFfz1WjirXjAkC5PNlCcB2NqcKE6239	intact-crc:945D9BC09B0B9A45|rigid:JH3KLBF/bwIWggvdsNCryj2YuoE	false	sufficient binding region:389-503	sufficient binding region:198-374|mutation:358-358	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42573	uniprotkb:P30429-2	intact:EBI-494247|uniprotkb:P45435|uniprotkb:Q9GQQ4|uniprotkb:Q9NAQ8|ensemblmetazoa:C48D1.2a.1	intact:EBI-536271|ensemblmetazoa:C35D10.9a.1|ensemblmetazoa:C35D10.9a.2	psi-mi:ced3_caeel(display_long)|uniprotkb:ced-3(gene name)|psi-mi:ced-3(display_short)|uniprotkb:Caspase ced-3(gene name synonym)|uniprotkb:C48D1.2(orf name)	psi-mi:p30429-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:C35D10.9(orf name)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)	psi-mi:"MI:0071"(molecular sieving)	Qi et al. (2010)	imex:IM-14139|pubmed:20434985	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2655200|imex:IM-14139-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001255708.1|wormbase:C48D1.2a|reactome:R-CEL-111465|reactome:R-CEL-198323|reactome:R-CEL-264870|reactome:R-CEL-448706|dip:DIP-244N|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0098793"(presynapse)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905845"(positive regulation of cellular response to gamma radiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:4M9R|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|ensemblmetazoa:C48D1.2a.1(transcript)|ensemblmetazoa:WBGene00000417(gene)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|reactome:R-CEL-140342|reactome:R-CEL-351906|reactome:R-CEL-418889	intact:EBI-494118(ced4_caeel)|ensemblmetazoa:C35D10.9a.1(transcript)|ensemblmetazoa:C35D10.9a.2(transcript)|ensemblmetazoa:WBGene00000418(gene)	psi-mi:"MI:0469"(intact)	-	isoform-comment:Major transcript.	figure legend:Supp. Fig. 5D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/05/06	2014/10/16	rogid:HFfz1WjirXjAkC5PNlCcB2NqcKE6239	rogid:sSkgk+GyIaamGk8NHz+MAMUxSQc6239	intact-crc:945D9BC09B0B9A45|rigid:JH3KLBF/bwIWggvdsNCryj2YuoE	false	sufficient binding region:389-503	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42573	uniprotkb:P42573	intact:EBI-494247|uniprotkb:P45435|uniprotkb:Q9GQQ4|uniprotkb:Q9NAQ8|ensemblmetazoa:C48D1.2a.1	intact:EBI-494247|uniprotkb:P45435|uniprotkb:Q9GQQ4|uniprotkb:Q9NAQ8|ensemblmetazoa:C48D1.2a.1	psi-mi:ced3_caeel(display_long)|uniprotkb:ced-3(gene name)|psi-mi:ced-3(display_short)|uniprotkb:Caspase ced-3(gene name synonym)|uniprotkb:C48D1.2(orf name)	psi-mi:ced3_caeel(display_long)|uniprotkb:ced-3(gene name)|psi-mi:ced-3(display_short)|uniprotkb:Caspase ced-3(gene name synonym)|uniprotkb:C48D1.2(orf name)	psi-mi:"MI:0027"(cosedimentation)	Qi et al. (2010)	imex:IM-14139|pubmed:20434985	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2655184|imex:IM-14139-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001255708.1|wormbase:C48D1.2a|reactome:R-CEL-111465|reactome:R-CEL-198323|reactome:R-CEL-264870|reactome:R-CEL-448706|dip:DIP-244N|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0098793"(presynapse)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905845"(positive regulation of cellular response to gamma radiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:4M9R|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|ensemblmetazoa:C48D1.2a.1(transcript)|ensemblmetazoa:WBGene00000417(gene)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|reactome:R-CEL-140342|reactome:R-CEL-351906|reactome:R-CEL-418889	refseq:NP_001255708.1|wormbase:C48D1.2a|reactome:R-CEL-111465|reactome:R-CEL-198323|reactome:R-CEL-264870|reactome:R-CEL-448706|dip:DIP-244N|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0098793"(presynapse)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905845"(positive regulation of cellular response to gamma radiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:4M9R|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|ensemblmetazoa:C48D1.2a.1(transcript)|ensemblmetazoa:WBGene00000417(gene)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|reactome:R-CEL-140342|reactome:R-CEL-351906|reactome:R-CEL-418889	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 5D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/05/06	2014/10/16	rogid:HFfz1WjirXjAkC5PNlCcB2NqcKE6239	rogid:HFfz1WjirXjAkC5PNlCcB2NqcKE6239	intact-crc:69D5D8C23AD99386|rigid:XdL/m8q0PSRI88m3vsFxiYYEGoo	false	sufficient binding region:198-374|mutation:358-358	sufficient binding region:389-503	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42573	uniprotkb:P42573	intact:EBI-494247|uniprotkb:P45435|uniprotkb:Q9GQQ4|uniprotkb:Q9NAQ8|ensemblmetazoa:C48D1.2a.1	intact:EBI-494247|uniprotkb:P45435|uniprotkb:Q9GQQ4|uniprotkb:Q9NAQ8|ensemblmetazoa:C48D1.2a.1	psi-mi:ced3_caeel(display_long)|uniprotkb:ced-3(gene name)|psi-mi:ced-3(display_short)|uniprotkb:Caspase ced-3(gene name synonym)|uniprotkb:C48D1.2(orf name)	psi-mi:ced3_caeel(display_long)|uniprotkb:ced-3(gene name)|psi-mi:ced-3(display_short)|uniprotkb:Caspase ced-3(gene name synonym)|uniprotkb:C48D1.2(orf name)	psi-mi:"MI:0401"(biochemical)	Qi et al. (2010)	imex:IM-14139|pubmed:20434985	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2655214|imex:IM-14139-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001255708.1|wormbase:C48D1.2a|reactome:R-CEL-111465|reactome:R-CEL-198323|reactome:R-CEL-264870|reactome:R-CEL-448706|dip:DIP-244N|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0098793"(presynapse)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905845"(positive regulation of cellular response to gamma radiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:4M9R|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|ensemblmetazoa:C48D1.2a.1(transcript)|ensemblmetazoa:WBGene00000417(gene)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|reactome:R-CEL-140342|reactome:R-CEL-351906|reactome:R-CEL-418889	refseq:NP_001255708.1|wormbase:C48D1.2a|reactome:R-CEL-111465|reactome:R-CEL-198323|reactome:R-CEL-264870|reactome:R-CEL-448706|dip:DIP-244N|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0098793"(presynapse)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905845"(positive regulation of cellular response to gamma radiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:4M9R|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|ensemblmetazoa:C48D1.2a.1(transcript)|ensemblmetazoa:WBGene00000417(gene)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|reactome:R-CEL-140342|reactome:R-CEL-351906|reactome:R-CEL-418889	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 5E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/05/06	2014/10/16	rogid:HFfz1WjirXjAkC5PNlCcB2NqcKE6239	rogid:HFfz1WjirXjAkC5PNlCcB2NqcKE6239	intact-crc:F9F0F8BF02245B5F|rigid:JH3KLBF/bwIWggvdsNCryj2YuoE	false	sufficient binding region:198-374|mutation:358-358	sufficient binding region:389-503	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42573	uniprotkb:P30429-2	intact:EBI-494247|uniprotkb:P45435|uniprotkb:Q9GQQ4|uniprotkb:Q9NAQ8|ensemblmetazoa:C48D1.2a.1	intact:EBI-536271|ensemblmetazoa:C35D10.9a.1|ensemblmetazoa:C35D10.9a.2	psi-mi:ced3_caeel(display_long)|uniprotkb:ced-3(gene name)|psi-mi:ced-3(display_short)|uniprotkb:Caspase ced-3(gene name synonym)|uniprotkb:C48D1.2(orf name)	psi-mi:p30429-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:C35D10.9(orf name)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)	psi-mi:"MI:0401"(biochemical)	Qi et al. (2010)	imex:IM-14139|pubmed:20434985	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2655214|imex:IM-14139-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001255708.1|wormbase:C48D1.2a|reactome:R-CEL-111465|reactome:R-CEL-198323|reactome:R-CEL-264870|reactome:R-CEL-448706|dip:DIP-244N|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0098793"(presynapse)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905845"(positive regulation of cellular response to gamma radiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:4M9R|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|ensemblmetazoa:C48D1.2a.1(transcript)|ensemblmetazoa:WBGene00000417(gene)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|reactome:R-CEL-140342|reactome:R-CEL-351906|reactome:R-CEL-418889	intact:EBI-494118(ced4_caeel)|ensemblmetazoa:C35D10.9a.1(transcript)|ensemblmetazoa:C35D10.9a.2(transcript)|ensemblmetazoa:WBGene00000418(gene)	psi-mi:"MI:0469"(intact)	-	isoform-comment:Major transcript.	figure legend:Supp. Fig. 5E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/05/06	2014/10/16	rogid:HFfz1WjirXjAkC5PNlCcB2NqcKE6239	rogid:sSkgk+GyIaamGk8NHz+MAMUxSQc6239	intact-crc:F9F0F8BF02245B5F|rigid:JH3KLBF/bwIWggvdsNCryj2YuoE	false	sufficient binding region:198-374|mutation:358-358	-	1	4	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42573	uniprotkb:P42573	intact:EBI-494247|uniprotkb:P45435|uniprotkb:Q9GQQ4|uniprotkb:Q9NAQ8|ensemblmetazoa:C48D1.2a.1	intact:EBI-494247|uniprotkb:P45435|uniprotkb:Q9GQQ4|uniprotkb:Q9NAQ8|ensemblmetazoa:C48D1.2a.1	psi-mi:ced3_caeel(display_long)|uniprotkb:ced-3(gene name)|psi-mi:ced-3(display_short)|uniprotkb:Caspase ced-3(gene name synonym)|uniprotkb:C48D1.2(orf name)	psi-mi:ced3_caeel(display_long)|uniprotkb:ced-3(gene name)|psi-mi:ced-3(display_short)|uniprotkb:Caspase ced-3(gene name synonym)|uniprotkb:C48D1.2(orf name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Qi et al. (2010)	imex:IM-14139|pubmed:20434985	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2655240|imex:IM-14139-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001255708.1|wormbase:C48D1.2a|reactome:R-CEL-111465|reactome:R-CEL-198323|reactome:R-CEL-264870|reactome:R-CEL-448706|dip:DIP-244N|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0098793"(presynapse)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905845"(positive regulation of cellular response to gamma radiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:4M9R|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|ensemblmetazoa:C48D1.2a.1(transcript)|ensemblmetazoa:WBGene00000417(gene)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|reactome:R-CEL-140342|reactome:R-CEL-351906|reactome:R-CEL-418889	refseq:NP_001255708.1|wormbase:C48D1.2a|reactome:R-CEL-111465|reactome:R-CEL-198323|reactome:R-CEL-264870|reactome:R-CEL-448706|dip:DIP-244N|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0098793"(presynapse)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905845"(positive regulation of cellular response to gamma radiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:4M9R|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|ensemblmetazoa:C48D1.2a.1(transcript)|ensemblmetazoa:WBGene00000417(gene)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|reactome:R-CEL-140342|reactome:R-CEL-351906|reactome:R-CEL-418889	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 5F|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/05/06	2014/10/16	rogid:HFfz1WjirXjAkC5PNlCcB2NqcKE6239	rogid:HFfz1WjirXjAkC5PNlCcB2NqcKE6239	intact-crc:B70F780AA9D07BB4|rigid:JH3KLBF/bwIWggvdsNCryj2YuoE	false	sufficient binding region:198-374|mutation:358-358	sufficient binding region:389-503	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42573	uniprotkb:P30429-2	intact:EBI-494247|uniprotkb:P45435|uniprotkb:Q9GQQ4|uniprotkb:Q9NAQ8|ensemblmetazoa:C48D1.2a.1	intact:EBI-536271|ensemblmetazoa:C35D10.9a.1|ensemblmetazoa:C35D10.9a.2	psi-mi:ced3_caeel(display_long)|uniprotkb:ced-3(gene name)|psi-mi:ced-3(display_short)|uniprotkb:Caspase ced-3(gene name synonym)|uniprotkb:C48D1.2(orf name)	psi-mi:p30429-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:C35D10.9(orf name)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Qi et al. (2010)	imex:IM-14139|pubmed:20434985	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2655240|imex:IM-14139-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001255708.1|wormbase:C48D1.2a|reactome:R-CEL-111465|reactome:R-CEL-198323|reactome:R-CEL-264870|reactome:R-CEL-448706|dip:DIP-244N|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0098793"(presynapse)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905845"(positive regulation of cellular response to gamma radiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:4M9R|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|ensemblmetazoa:C48D1.2a.1(transcript)|ensemblmetazoa:WBGene00000417(gene)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|reactome:R-CEL-140342|reactome:R-CEL-351906|reactome:R-CEL-418889	intact:EBI-494118(ced4_caeel)|ensemblmetazoa:C35D10.9a.1(transcript)|ensemblmetazoa:C35D10.9a.2(transcript)|ensemblmetazoa:WBGene00000418(gene)	psi-mi:"MI:0469"(intact)	-	isoform-comment:Major transcript.	figure legend:Supp. Fig. 5F|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/05/06	2014/10/16	rogid:HFfz1WjirXjAkC5PNlCcB2NqcKE6239	rogid:sSkgk+GyIaamGk8NHz+MAMUxSQc6239	intact-crc:B70F780AA9D07BB4|rigid:JH3KLBF/bwIWggvdsNCryj2YuoE	false	sufficient binding region:198-374|mutation:358-358	-	1	4	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42573	uniprotkb:P42573	intact:EBI-494247|uniprotkb:P45435|uniprotkb:Q9GQQ4|uniprotkb:Q9NAQ8|ensemblmetazoa:C48D1.2a.1	intact:EBI-494247|uniprotkb:P45435|uniprotkb:Q9GQQ4|uniprotkb:Q9NAQ8|ensemblmetazoa:C48D1.2a.1	psi-mi:ced3_caeel(display_long)|uniprotkb:ced-3(gene name)|psi-mi:ced-3(display_short)|uniprotkb:Caspase ced-3(gene name synonym)|uniprotkb:C48D1.2(orf name)	psi-mi:ced3_caeel(display_long)|uniprotkb:ced-3(gene name)|psi-mi:ced-3(display_short)|uniprotkb:Caspase ced-3(gene name synonym)|uniprotkb:C48D1.2(orf name)	psi-mi:"MI:0808"(comigration in sds page)	Qi et al. (2010)	imex:IM-14139|pubmed:20434985	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2655261|imex:IM-14139-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001255708.1|wormbase:C48D1.2a|reactome:R-CEL-111465|reactome:R-CEL-198323|reactome:R-CEL-264870|reactome:R-CEL-448706|dip:DIP-244N|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0098793"(presynapse)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905845"(positive regulation of cellular response to gamma radiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:4M9R|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|ensemblmetazoa:C48D1.2a.1(transcript)|ensemblmetazoa:WBGene00000417(gene)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|reactome:R-CEL-140342|reactome:R-CEL-351906|reactome:R-CEL-418889	refseq:NP_001255708.1|wormbase:C48D1.2a|reactome:R-CEL-111465|reactome:R-CEL-198323|reactome:R-CEL-264870|reactome:R-CEL-448706|dip:DIP-244N|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0098793"(presynapse)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905845"(positive regulation of cellular response to gamma radiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:4M9R|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|ensemblmetazoa:C48D1.2a.1(transcript)|ensemblmetazoa:WBGene00000417(gene)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|reactome:R-CEL-140342|reactome:R-CEL-351906|reactome:R-CEL-418889	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 6A|comment:"Although ced-3 was not visible in a ced-3:ced-4 crystal, subsequent analysis of the crystals showed both proteins to be present."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/05/06	2014/10/16	rogid:HFfz1WjirXjAkC5PNlCcB2NqcKE6239	rogid:HFfz1WjirXjAkC5PNlCcB2NqcKE6239	intact-crc:CEAD98BF42C20AF2|rigid:JH3KLBF/bwIWggvdsNCryj2YuoE	false	sufficient binding region:389-503	sufficient binding region:198-374|mutation:358-358	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P42573	uniprotkb:P30429-2	intact:EBI-494247|uniprotkb:P45435|uniprotkb:Q9GQQ4|uniprotkb:Q9NAQ8|ensemblmetazoa:C48D1.2a.1	intact:EBI-536271|ensemblmetazoa:C35D10.9a.1|ensemblmetazoa:C35D10.9a.2	psi-mi:ced3_caeel(display_long)|uniprotkb:ced-3(gene name)|psi-mi:ced-3(display_short)|uniprotkb:Caspase ced-3(gene name synonym)|uniprotkb:C48D1.2(orf name)	psi-mi:p30429-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:C35D10.9(orf name)|uniprotkb:ced-4(gene name)|psi-mi:ced-4(display_short)	psi-mi:"MI:0808"(comigration in sds page)	Qi et al. (2010)	imex:IM-14139|pubmed:20434985	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2655261|imex:IM-14139-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001255708.1|wormbase:C48D1.2a|reactome:R-CEL-111465|reactome:R-CEL-198323|reactome:R-CEL-264870|reactome:R-CEL-448706|dip:DIP-244N|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0098793"(presynapse)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905845"(positive regulation of cellular response to gamma radiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:4M9R|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|ensemblmetazoa:C48D1.2a.1(transcript)|ensemblmetazoa:WBGene00000417(gene)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|reactome:R-CEL-140342|reactome:R-CEL-351906|reactome:R-CEL-418889	intact:EBI-494118(ced4_caeel)|ensemblmetazoa:C35D10.9a.1(transcript)|ensemblmetazoa:C35D10.9a.2(transcript)|ensemblmetazoa:WBGene00000418(gene)	psi-mi:"MI:0469"(intact)	-	isoform-comment:Major transcript.	figure legend:Supp. Fig. 6A|comment:"Although ced-3 was not visible in a ced-3:ced-4 crystal, subsequent analysis of the crystals showed both proteins to be present."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/05/06	2014/10/16	rogid:HFfz1WjirXjAkC5PNlCcB2NqcKE6239	rogid:sSkgk+GyIaamGk8NHz+MAMUxSQc6239	intact-crc:CEAD98BF42C20AF2|rigid:JH3KLBF/bwIWggvdsNCryj2YuoE	false	sufficient binding region:389-503	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
chebi:"CHEBI:59385"	uniprotkb:P42573	intact:EBI-2655274	intact:EBI-494247|uniprotkb:P45435|uniprotkb:Q9GQQ4|uniprotkb:Q9NAQ8|ensemblmetazoa:C48D1.2a.1	psi-mi:ac-devd-cho(display_short)|psi-mi:"CHEBI:59385"(display_long)	psi-mi:ced3_caeel(display_long)|uniprotkb:ced-3(gene name)|psi-mi:ced-3(display_short)|uniprotkb:Caspase ced-3(gene name synonym)|uniprotkb:C48D1.2(orf name)	psi-mi:"MI:0071"(molecular sieving)	Qi et al. (2010)	imex:IM-14139|pubmed:20434985	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2655281|imex:IM-14139-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001255708.1|wormbase:C48D1.2a|reactome:R-CEL-111465|reactome:R-CEL-198323|reactome:R-CEL-264870|reactome:R-CEL-448706|dip:DIP-244N|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0098793"(presynapse)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905845"(positive regulation of cellular response to gamma radiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:4M9R|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|ensemblmetazoa:C48D1.2a.1(transcript)|ensemblmetazoa:WBGene00000417(gene)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|reactome:R-CEL-140342|reactome:R-CEL-351906|reactome:R-CEL-418889	-	-	-	figure legend:Supp. Fig. 6A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/05/06	2014/10/16	-	rogid:HFfz1WjirXjAkC5PNlCcB2NqcKE6239	intact-crc:F8A10C7BE9AC1937	false	-	his tag:c-c|sufficient binding region:198-503	-	2	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)