#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8IZQ1 uniprotkb:Q9H1Y0 intact:EBI-1569256|uniprotkb:Q4W5K5|uniprotkb:Q6P0Q5|uniprotkb:Q8N1T2|uniprotkb:Q8NAV6|uniprotkb:Q96BS7|uniprotkb:Q96D33|uniprotkb:Q96N85|uniprotkb:Q9Y2J7|ensembl:ENSP00000295888 intact:EBI-1047414|uniprotkb:O60875|uniprotkb:Q5JVR2|uniprotkb:Q68DI4|uniprotkb:Q9H2B8|uniprotkb:Q9HCZ7|ensembl:ENSP00000343313|ensembl:ENSP00000358072 psi-mi:wdfy3_human(display_long)|uniprotkb:Autophagy-linked FYVE protein(gene name synonym)|uniprotkb:WDFY3(gene name)|psi-mi:WDFY3(display_short)|uniprotkb:KIAA0993(gene name synonym) psi-mi:atg5_human(display_long)|uniprotkb:APG5-like(gene name synonym)|uniprotkb:Apoptosis-specific protein(gene name synonym)|uniprotkb:ATG5(gene name)|psi-mi:ATG5(display_short)|uniprotkb:APG5L(gene name synonym)|uniprotkb:ASP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2935292|imex:IM-20521-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055806.2|refseq:XP_011530065.1|refseq:XP_011530067.1|ensembl:ENSG00000163625(gene)|ensembl:ENST00000295888(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR036322|interpro:IPR036372|mint:Q8IZQ1|rcsb pdb:3WIM|rcsb pdb:6W9N refseq:NP_001273035.1|refseq:NP_001273036.1|refseq:NP_001273037.1|refseq:NP_001273040.1|refseq:NP_004840.1|dip:DIP-29758N|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009620"(response to fungus)|go:"GO:0016020"(membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0035973"(aggrephagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0048840"(otolith development)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060047"(heart contraction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR007239(Autophagy protein 5)|interpro:IPR042526|interpro:IPR042527|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:4TQ1|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8934903|reactome:R-HSA-936440|ensembl:ENSG00000057663(gene)|ensembl:ENST00000343245(transcript)|ensembl:ENST00000369076(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002718"(regulation of cytokine production involved in immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006501"(C-terminal protein lipidation) - - - figure legend:Fig 4B.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2010/10/13 2014/10/16 rogid:yVIfhD/TU9JhrQR8WCChT4Jpi8c9606 rogid:YqK4btJDQmY/dGxrmYxQmL+iAzc9606 intact-crc:E52648D727C310D5|rigid:82ryasy2E7Y2VhXu400syk+WlLQ false sufficient binding region:2981-3526(IPR011046)|fluorophore:?-? myc tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P42858 uniprotkb:O94817 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 intact:EBI-746742|uniprotkb:Q6PJV2|ensembl:ENSP00000425107 psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:atg12_human(display_long)|uniprotkb:Autophagy-related protein 12(gene name synonym)|uniprotkb:ATG12(gene name)|psi-mi:ATG12(display_short)|uniprotkb:APG12(gene name synonym)|uniprotkb:APG12L(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2935599|imex:IM-20521-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8934903|reactome:R-HSA-936440|refseq:NP_004698.3|ensembl:ENSG00000145782(gene)|ensembl:ENST00000509910(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006501"(C-terminal protein lipidation)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0044804"(autophagy of nucleus)|interpro:IPR007242(Autophagy protein 12)|interpro:IPR029071|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|refseq:NP_001264712.1|dip:DIP-46466N - - - figure legend:Fig 4F.|caution:"The Htt sequence is stated to be \"exon1\", but the exact amino acid numbers are not given."|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2010/10/13 2014/10/16 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 rogid:V+K93xoWUNtOTJk4k03IP+Q+HfA9606 intact-crc:6FF5D26247F4AF47|rigid:wiUWv1IcJCL0QHW4dq5Uu3rNWkM false cyan fluorescent protein tag:c-c|sufficient binding region:1-170..170 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P42858 uniprotkb:Q676U5 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 intact:EBI-535909|uniprotkb:Q6IPN1|uniprotkb:Q6UXW4|uniprotkb:Q6ZVZ5|uniprotkb:Q8NCY2|uniprotkb:Q96JV5|uniprotkb:Q9H619|uniprotkb:A3EXK9|uniprotkb:A3EXL0|uniprotkb:B6ZDH0|ensembl:ENSP00000375872|ensembl:ENSP00000487542 psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:a16l1_human(display_long)|uniprotkb:APG16-like 1(gene name synonym)|uniprotkb:UNQ9393/PRO34307(orf name)|uniprotkb:ATG16L1(gene name)|psi-mi:ATG16L1(display_short)|uniprotkb:APG16L(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2935599|imex:IM-20521-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N refseq:NP_001177195.1|refseq:NP_001177196.1|refseq:NP_060444.3|refseq:NP_110430.5|refseq:NP_942593.2|dip:DIP-27552N|dip:DIP-50290N|ensembl:ENSG00000085978(gene)|ensembl:ENSG00000281089(gene)|ensembl:ENST00000392017(transcript)|ensembl:ENST00000625501(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0098792"(xenophagy)|go:"GO:0120095"(vacuole-isolation membrane contact site)|interpro:IPR001680(WD40 repeat)|interpro:IPR013923(Autophagy protein 16)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q676U5|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|rcsb pdb:5NUV|rcsb pdb:5ZYX|reactome:R-HSA-1632852 - - - figure legend:Fig 4F.|caution:"The Htt sequence is stated to be \"exon1\", but the exact amino acid numbers are not given."|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2010/10/13 2014/10/16 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 rogid:rLwpmIwMwd/GgPJA+7OKYTnn73E9606 intact-crc:6FF5D26247F4AF47|rigid:wiUWv1IcJCL0QHW4dq5Uu3rNWkM false cyan fluorescent protein tag:c-c|sufficient binding region:1-170..170 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P42858 uniprotkb:Q8IZQ1 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 intact:EBI-1569256|uniprotkb:Q4W5K5|uniprotkb:Q6P0Q5|uniprotkb:Q8N1T2|uniprotkb:Q8NAV6|uniprotkb:Q96BS7|uniprotkb:Q96D33|uniprotkb:Q96N85|uniprotkb:Q9Y2J7|ensembl:ENSP00000295888 psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:wdfy3_human(display_long)|uniprotkb:Autophagy-linked FYVE protein(gene name synonym)|uniprotkb:WDFY3(gene name)|psi-mi:WDFY3(display_short)|uniprotkb:KIAA0993(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2935627|imex:IM-20521-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N refseq:NP_055806.2|refseq:XP_011530065.1|refseq:XP_011530067.1|ensembl:ENSG00000163625(gene)|ensembl:ENST00000295888(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR036322|interpro:IPR036372|mint:Q8IZQ1|rcsb pdb:3WIM|rcsb pdb:6W9N - - - figure legend:Fig 5A.|caution:"The Htt sequence is stated to be \"exon1\", but the exact amino acid numbers are not given."|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2010/10/13 2014/10/16 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 rogid:yVIfhD/TU9JhrQR8WCChT4Jpi8c9606 intact-crc:1B37E040537723DF|rigid:97vhWCh75bInNtq2UyiD0QYn78U false cyan fluorescent protein tag:c-c|sufficient binding region:1-130..130 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P42858 uniprotkb:Q13501 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 intact:EBI-307104|uniprotkb:Q13446|uniprotkb:Q9BUV7|uniprotkb:Q9BVS6|uniprotkb:Q9UEU1|uniprotkb:A6NFN7|uniprotkb:B2R661|uniprotkb:B3KUW5|intact:EBI-28976133|ensembl:ENSP00000374455 psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:sqstm_human(display_long)|uniprotkb:SQSTM1(gene name)|psi-mi:SQSTM1(display_short)|uniprotkb:ORCA(gene name synonym)|uniprotkb:OSIL(gene name synonym)|uniprotkb:Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa(gene name synonym)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym)|uniprotkb:EBI3-associated protein of 60 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2935627|imex:IM-20521-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N ensembl:ENST00000360718|ensembl:ENSP00000353944|ensembl:ENSP00000374455|ensembl:ENSG00000161011(gene)|ensembl:ENST00000389805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016197"(endosomal transport)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR033741|go:"GO:0044753"(amphisome)|interpro:IPR034866|interpro:IPR043145|mint:Q13501|rcsb pdb:1Q02|rcsb pdb:2JY7|rcsb pdb:2JY8|rcsb pdb:2K0B|rcsb pdb:2KNV|go:"GO:0044754"(autolysosome)|rcsb pdb:4MJS|rcsb pdb:4UF8|rcsb pdb:4UF9|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:5YP7|rcsb pdb:5YP8|rcsb pdb:5YPA|rcsb pdb:5YPB|rcsb pdb:5YPC|rcsb pdb:5YPE|rcsb pdb:5YPF|rcsb pdb:5YPG|rcsb pdb:5YPH|rcsb pdb:6JM4|rcsb pdb:6KHZ|rcsb pdb:6MJ7|rcsb pdb:6TGY|rcsb pdb:6TH3|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-5205685|reactome:R-HSA-9020702|reactome:R-HSA-9664873|refseq:NP_001135770.1|refseq:NP_001135771.1|refseq:NP_003891.1|dip:DIP-34443N|refseq:XP_016865499.1 - - - figure legend:Fig 5A.|caution:"The Htt sequence is stated to be \"exon1\", but the exact amino acid numbers are not given."|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2010/10/13 2014/10/16 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 rogid:paIcBLmyiv1+D9QMym5MY3yc8MI9606 intact-crc:1B37E040537723DF|rigid:97vhWCh75bInNtq2UyiD0QYn78U false cyan fluorescent protein tag:c-c|sufficient binding region:1-130..130 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P42858 uniprotkb:Q9H1Y0 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 intact:EBI-1047414|uniprotkb:O60875|uniprotkb:Q5JVR2|uniprotkb:Q68DI4|uniprotkb:Q9H2B8|uniprotkb:Q9HCZ7|ensembl:ENSP00000343313|ensembl:ENSP00000358072 psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:atg5_human(display_long)|uniprotkb:APG5-like(gene name synonym)|uniprotkb:Apoptosis-specific protein(gene name synonym)|uniprotkb:ATG5(gene name)|psi-mi:ATG5(display_short)|uniprotkb:APG5L(gene name synonym)|uniprotkb:ASP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2935627|imex:IM-20521-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N refseq:NP_001273035.1|refseq:NP_001273036.1|refseq:NP_001273037.1|refseq:NP_001273040.1|refseq:NP_004840.1|dip:DIP-29758N|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009620"(response to fungus)|go:"GO:0016020"(membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0035973"(aggrephagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0048840"(otolith development)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060047"(heart contraction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR007239(Autophagy protein 5)|interpro:IPR042526|interpro:IPR042527|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:4TQ1|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8934903|reactome:R-HSA-936440|ensembl:ENSG00000057663(gene)|ensembl:ENST00000343245(transcript)|ensembl:ENST00000369076(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002718"(regulation of cytokine production involved in immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006501"(C-terminal protein lipidation) - - - figure legend:Fig 5A.|caution:"The Htt sequence is stated to be \"exon1\", but the exact amino acid numbers are not given."|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2010/10/13 2014/10/16 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 rogid:YqK4btJDQmY/dGxrmYxQmL+iAzc9606 intact-crc:1B37E040537723DF|rigid:97vhWCh75bInNtq2UyiD0QYn78U false cyan fluorescent protein tag:c-c|sufficient binding region:1-130..130 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P42858 uniprotkb:Q9GZQ8 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 intact:EBI-373144|uniprotkb:Q6NW02|intact:EBI-28979688|ensembl:ENSP00000268607|ensembl:ENSP00000498476 psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:mlp3b_human(display_long)|uniprotkb:MAP1LC3B(gene name)|psi-mi:MAP1LC3B(display_short)|uniprotkb:MAP1ALC3(gene name synonym)|uniprotkb:Microtubule-associated protein 1 light chain 3 beta(gene name synonym)|uniprotkb:MAP1A/MAP1B light chain 3 B(gene name synonym)|uniprotkb:MAP1 light chain 3-like protein 2(gene name synonym)|uniprotkb:Autophagy-related protein LC3 B(gene name synonym)|uniprotkb:Autophagy-related ubiquitin-like modifier LC3 B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2935627|imex:IM-20521-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N ensembl:ENSP00000268607|ensembl:ENSP00000498476|refseq:NP_073729.1|ensembl:ENSG00000140941(gene)|ensembl:ENST00000268607(transcript)|ensembl:ENST00000650688(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0008017"(microtubule binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0012505"(endomembrane system)|go:"GO:0016236"(macroautophagy)|go:"GO:0031090"(organelle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0097001"(ceramide binding)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR004241("Light chain 3 (LC3)")|interpro:IPR029071|mint:Q9GZQ8|rcsb pdb:1V49|rcsb pdb:2LUE|rcsb pdb:2N9X|rcsb pdb:2ZJD|rcsb pdb:3VTU|rcsb pdb:3VTV|rcsb pdb:3VTW|rcsb pdb:3WAO|rcsb pdb:3X0W|rcsb pdb:4WAA|rcsb pdb:5D94|rcsb pdb:5DCN|rcsb pdb:5GMV|rcsb pdb:5MS2|rcsb pdb:5MS5|rcsb pdb:5MS6|rcsb pdb:5V4K|rcsb pdb:5W9A|rcsb pdb:5XAC|rcsb pdb:5XAD|rcsb pdb:5XAE|rcsb pdb:6J04|rcsb pdb:6LAN|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8854214|reactome:R-HSA-8934903|reactome:R-HSA-9664873|reactome:R-HSA-9679504|reactome:R-HSA-9694676|dip:DIP-29760N - - - figure legend:Fig 5A.|caution:"The Htt sequence is stated to be \"exon1\", but the exact amino acid numbers are not given."|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2010/10/13 2014/10/16 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 rogid:yUk3FGI9csW9DNlqWkewtqM2VN09606 intact-crc:1B37E040537723DF|rigid:97vhWCh75bInNtq2UyiD0QYn78U false cyan fluorescent protein tag:c-c|sufficient binding region:1-130..130 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P42858 uniprotkb:Q9GZQ8 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 intact:EBI-373144|uniprotkb:Q6NW02|intact:EBI-28979688|ensembl:ENSP00000268607|ensembl:ENSP00000498476 psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:mlp3b_human(display_long)|uniprotkb:MAP1LC3B(gene name)|psi-mi:MAP1LC3B(display_short)|uniprotkb:MAP1ALC3(gene name synonym)|uniprotkb:Microtubule-associated protein 1 light chain 3 beta(gene name synonym)|uniprotkb:MAP1A/MAP1B light chain 3 B(gene name synonym)|uniprotkb:MAP1 light chain 3-like protein 2(gene name synonym)|uniprotkb:Autophagy-related protein LC3 B(gene name synonym)|uniprotkb:Autophagy-related ubiquitin-like modifier LC3 B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2935663|imex:IM-20521-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N ensembl:ENSP00000268607|ensembl:ENSP00000498476|refseq:NP_073729.1|ensembl:ENSG00000140941(gene)|ensembl:ENST00000268607(transcript)|ensembl:ENST00000650688(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0008017"(microtubule binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0012505"(endomembrane system)|go:"GO:0016236"(macroautophagy)|go:"GO:0031090"(organelle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0097001"(ceramide binding)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR004241("Light chain 3 (LC3)")|interpro:IPR029071|mint:Q9GZQ8|rcsb pdb:1V49|rcsb pdb:2LUE|rcsb pdb:2N9X|rcsb pdb:2ZJD|rcsb pdb:3VTU|rcsb pdb:3VTV|rcsb pdb:3VTW|rcsb pdb:3WAO|rcsb pdb:3X0W|rcsb pdb:4WAA|rcsb pdb:5D94|rcsb pdb:5DCN|rcsb pdb:5GMV|rcsb pdb:5MS2|rcsb pdb:5MS5|rcsb pdb:5MS6|rcsb pdb:5V4K|rcsb pdb:5W9A|rcsb pdb:5XAC|rcsb pdb:5XAD|rcsb pdb:5XAE|rcsb pdb:6J04|rcsb pdb:6LAN|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8854214|reactome:R-HSA-8934903|reactome:R-HSA-9664873|reactome:R-HSA-9679504|reactome:R-HSA-9694676|dip:DIP-29760N - - - figure legend:Fig 5A, 5D.|caution:"The Htt sequence is stated to be \"exon1\", but the exact amino acid numbers are not given."|comment:"Alfie knockdown (si-Alfy) diminished the interaction with Atg5, and a diminished amount of LC3 was present in the complex."|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2010/10/13 2014/10/16 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 rogid:yUk3FGI9csW9DNlqWkewtqM2VN09606 intact-crc:813477E4A5BD0124|rigid:97vhWCh75bInNtq2UyiD0QYn78U false cyan fluorescent protein tag:c-c|sufficient binding region:1-170..170 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P42858 uniprotkb:Q8IZQ1 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 intact:EBI-1569256|uniprotkb:Q4W5K5|uniprotkb:Q6P0Q5|uniprotkb:Q8N1T2|uniprotkb:Q8NAV6|uniprotkb:Q96BS7|uniprotkb:Q96D33|uniprotkb:Q96N85|uniprotkb:Q9Y2J7|ensembl:ENSP00000295888 psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:wdfy3_human(display_long)|uniprotkb:Autophagy-linked FYVE protein(gene name synonym)|uniprotkb:WDFY3(gene name)|psi-mi:WDFY3(display_short)|uniprotkb:KIAA0993(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2935663|imex:IM-20521-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N refseq:NP_055806.2|refseq:XP_011530065.1|refseq:XP_011530067.1|ensembl:ENSG00000163625(gene)|ensembl:ENST00000295888(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR036322|interpro:IPR036372|mint:Q8IZQ1|rcsb pdb:3WIM|rcsb pdb:6W9N - - - figure legend:Fig 5A, 5D.|caution:"The Htt sequence is stated to be \"exon1\", but the exact amino acid numbers are not given."|comment:"Alfie knockdown (si-Alfy) diminished the interaction with Atg5, and a diminished amount of LC3 was present in the complex."|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2010/10/13 2014/10/16 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 rogid:yVIfhD/TU9JhrQR8WCChT4Jpi8c9606 intact-crc:813477E4A5BD0124|rigid:97vhWCh75bInNtq2UyiD0QYn78U false cyan fluorescent protein tag:c-c|sufficient binding region:1-170..170 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P42858 uniprotkb:Q13501 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 intact:EBI-307104|uniprotkb:Q13446|uniprotkb:Q9BUV7|uniprotkb:Q9BVS6|uniprotkb:Q9UEU1|uniprotkb:A6NFN7|uniprotkb:B2R661|uniprotkb:B3KUW5|intact:EBI-28976133|ensembl:ENSP00000374455 psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:sqstm_human(display_long)|uniprotkb:SQSTM1(gene name)|psi-mi:SQSTM1(display_short)|uniprotkb:ORCA(gene name synonym)|uniprotkb:OSIL(gene name synonym)|uniprotkb:Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa(gene name synonym)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym)|uniprotkb:EBI3-associated protein of 60 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2935663|imex:IM-20521-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N ensembl:ENST00000360718|ensembl:ENSP00000353944|ensembl:ENSP00000374455|ensembl:ENSG00000161011(gene)|ensembl:ENST00000389805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016197"(endosomal transport)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR033741|go:"GO:0044753"(amphisome)|interpro:IPR034866|interpro:IPR043145|mint:Q13501|rcsb pdb:1Q02|rcsb pdb:2JY7|rcsb pdb:2JY8|rcsb pdb:2K0B|rcsb pdb:2KNV|go:"GO:0044754"(autolysosome)|rcsb pdb:4MJS|rcsb pdb:4UF8|rcsb pdb:4UF9|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:5YP7|rcsb pdb:5YP8|rcsb pdb:5YPA|rcsb pdb:5YPB|rcsb pdb:5YPC|rcsb pdb:5YPE|rcsb pdb:5YPF|rcsb pdb:5YPG|rcsb pdb:5YPH|rcsb pdb:6JM4|rcsb pdb:6KHZ|rcsb pdb:6MJ7|rcsb pdb:6TGY|rcsb pdb:6TH3|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-5205685|reactome:R-HSA-9020702|reactome:R-HSA-9664873|refseq:NP_001135770.1|refseq:NP_001135771.1|refseq:NP_003891.1|dip:DIP-34443N|refseq:XP_016865499.1 - - - figure legend:Fig 5A, 5D.|caution:"The Htt sequence is stated to be \"exon1\", but the exact amino acid numbers are not given."|comment:"Alfie knockdown (si-Alfy) diminished the interaction with Atg5, and a diminished amount of LC3 was present in the complex."|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2010/10/13 2014/10/16 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 rogid:paIcBLmyiv1+D9QMym5MY3yc8MI9606 intact-crc:813477E4A5BD0124|rigid:97vhWCh75bInNtq2UyiD0QYn78U false cyan fluorescent protein tag:c-c|sufficient binding region:1-170..170 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P42858 uniprotkb:Q9H1Y0 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 intact:EBI-1047414|uniprotkb:O60875|uniprotkb:Q5JVR2|uniprotkb:Q68DI4|uniprotkb:Q9H2B8|uniprotkb:Q9HCZ7|ensembl:ENSP00000343313|ensembl:ENSP00000358072 psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:atg5_human(display_long)|uniprotkb:APG5-like(gene name synonym)|uniprotkb:Apoptosis-specific protein(gene name synonym)|uniprotkb:ATG5(gene name)|psi-mi:ATG5(display_short)|uniprotkb:APG5L(gene name synonym)|uniprotkb:ASP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2935663|imex:IM-20521-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N refseq:NP_001273035.1|refseq:NP_001273036.1|refseq:NP_001273037.1|refseq:NP_001273040.1|refseq:NP_004840.1|dip:DIP-29758N|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009620"(response to fungus)|go:"GO:0016020"(membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0035973"(aggrephagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0048840"(otolith development)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060047"(heart contraction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR007239(Autophagy protein 5)|interpro:IPR042526|interpro:IPR042527|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:4TQ1|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8934903|reactome:R-HSA-936440|ensembl:ENSG00000057663(gene)|ensembl:ENST00000343245(transcript)|ensembl:ENST00000369076(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002718"(regulation of cytokine production involved in immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006501"(C-terminal protein lipidation) - - - figure legend:Fig 5A, 5D.|caution:"The Htt sequence is stated to be \"exon1\", but the exact amino acid numbers are not given."|comment:"Alfie knockdown (si-Alfy) diminished the interaction with Atg5, and a diminished amount of LC3 was present in the complex."|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2010/10/13 2014/10/16 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 rogid:YqK4btJDQmY/dGxrmYxQmL+iAzc9606 intact-crc:813477E4A5BD0124|rigid:97vhWCh75bInNtq2UyiD0QYn78U false cyan fluorescent protein tag:c-c|sufficient binding region:1-170..170 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IZQ1 uniprotkb:P42858 intact:EBI-1569256|uniprotkb:Q4W5K5|uniprotkb:Q6P0Q5|uniprotkb:Q8N1T2|uniprotkb:Q8NAV6|uniprotkb:Q96BS7|uniprotkb:Q96D33|uniprotkb:Q96N85|uniprotkb:Q9Y2J7|ensembl:ENSP00000295888 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 psi-mi:wdfy3_human(display_long)|uniprotkb:Autophagy-linked FYVE protein(gene name synonym)|uniprotkb:WDFY3(gene name)|psi-mi:WDFY3(display_short)|uniprotkb:KIAA0993(gene name synonym) psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2935738|imex:IM-20521-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055806.2|refseq:XP_011530065.1|refseq:XP_011530067.1|ensembl:ENSG00000163625(gene)|ensembl:ENST00000295888(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR036322|interpro:IPR036372|mint:Q8IZQ1|rcsb pdb:3WIM|rcsb pdb:6W9N ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N - - - figure legend:Fig 5B.|caution:"The Htt sequence is stated to be \"exon1\", but the exact amino acid numbers are not given. The image legend states the c-terminal sequence of Alfy is aa 2543-3527, but the protein ends at aa 3526."|comment:Both the N- and C-terminal fragments of Alfy can interact with the polyQ protein.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2010/10/13 2014/10/16 rogid:yVIfhD/TU9JhrQR8WCChT4Jpi8c9606 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 intact-crc:EBD6E1D850813277|rigid:oRbN0FizZPRo7b7BHtWvEzcUUtM false sufficient binding region:1-1271|myc tag:?-?|sufficient binding region:2543-3526 cyan fluorescent protein tag:c-c|sufficient binding region:1-170..170 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q14596 uniprotkb:P42858 intact:EBI-742698|uniprotkb:Q13173|uniprotkb:Q15026|uniprotkb:Q96GB6|uniprotkb:Q9NRF7|uniprotkb:Q5J7Q8|intact:EBI-2859623|ensembl:ENSP00000343479|ensembl:ENSP00000466667 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 psi-mi:nbr1_human(display_long)|uniprotkb:Neighbor of BRCA1 gene 1 protein(gene name synonym)|uniprotkb:Membrane component chromosome 17 surface marker 2(gene name synonym)|uniprotkb:Protein 1A1-3B(gene name synonym)|uniprotkb:NBR1(gene name)|psi-mi:NBR1(display_short)|uniprotkb:1A13B(gene name synonym)|uniprotkb:KIAA0049(gene name synonym)|uniprotkb:M17S2(gene name synonym)|uniprotkb:Cell migration-inducing gene 19 protein(gene name synonym)|uniprotkb:MIG19(orf name) psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2936092|imex:IM-20521-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005890.2|refseq:NP_114068.1|ensembl:ENST00000341165(transcript)|ensembl:ENST00000590996(transcript)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016604"(nuclear body)|ensembl:ENSG00000188554(gene)|refseq:XP_011523115.1|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0031430"(M band)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0051019"(mitogen-activated protein kinase binding)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR032350|interpro:IPR033513|interpro:IPR034852|interpro:IPR043145|mint:Q14596|rcsb pdb:1WJ6|rcsb pdb:2BKF|rcsb pdb:2CP8|rcsb pdb:2G4S|rcsb pdb:2L8J|rcsb pdb:2MGW|rcsb pdb:2MJ5|rcsb pdb:4OLE|reactome:R-HSA-9664873|refseq:NP_001278500.1|refseq:NP_001278501.1|refseq:XP_016880131.1 ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N - - - figure legend:Fig 5G.|caution:"The Htt sequence is stated to be \"exon1\", but the exact amino acid numbers are not given."|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2010/10/13 2014/10/16 rogid:rRlRq4sK4fkVQCliQ68/MIEOX6g9606 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 intact-crc:D3CD6207AC6557F1|rigid:zHwu5KTC1Ei7+HNt2YlFJTpgZhk false - cyan fluorescent protein tag:c-c|sufficient binding region:1-130..130 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q14596 uniprotkb:P42858 intact:EBI-742698|uniprotkb:Q13173|uniprotkb:Q15026|uniprotkb:Q96GB6|uniprotkb:Q9NRF7|uniprotkb:Q5J7Q8|intact:EBI-2859623|ensembl:ENSP00000343479|ensembl:ENSP00000466667 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 psi-mi:nbr1_human(display_long)|uniprotkb:Neighbor of BRCA1 gene 1 protein(gene name synonym)|uniprotkb:Membrane component chromosome 17 surface marker 2(gene name synonym)|uniprotkb:Protein 1A1-3B(gene name synonym)|uniprotkb:NBR1(gene name)|psi-mi:NBR1(display_short)|uniprotkb:1A13B(gene name synonym)|uniprotkb:KIAA0049(gene name synonym)|uniprotkb:M17S2(gene name synonym)|uniprotkb:Cell migration-inducing gene 19 protein(gene name synonym)|uniprotkb:MIG19(orf name) psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2936102|imex:IM-20521-16 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005890.2|refseq:NP_114068.1|ensembl:ENST00000341165(transcript)|ensembl:ENST00000590996(transcript)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016604"(nuclear body)|ensembl:ENSG00000188554(gene)|refseq:XP_011523115.1|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0031430"(M band)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0051019"(mitogen-activated protein kinase binding)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR032350|interpro:IPR033513|interpro:IPR034852|interpro:IPR043145|mint:Q14596|rcsb pdb:1WJ6|rcsb pdb:2BKF|rcsb pdb:2CP8|rcsb pdb:2G4S|rcsb pdb:2L8J|rcsb pdb:2MGW|rcsb pdb:2MJ5|rcsb pdb:4OLE|reactome:R-HSA-9664873|refseq:NP_001278500.1|refseq:NP_001278501.1|refseq:XP_016880131.1 ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N - - - figure legend:Fig 5G.|caution:"The Htt sequence is stated to be \"exon1\", but the exact amino acid numbers are not given. The image legend states the c-terminal sequence of Alfy is aa 2543-3527, but the protein ends at aa 3526."|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2010/10/13 2014/10/16 rogid:rRlRq4sK4fkVQCliQ68/MIEOX6g9606 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 intact-crc:8424284EA352CC8D|rigid:zHwu5KTC1Ei7+HNt2YlFJTpgZhk false - cyan fluorescent protein tag:c-c|sufficient binding region:1-170..170 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P37840 uniprotkb:Q9H1Y0 intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4 intact:EBI-1047414|uniprotkb:O60875|uniprotkb:Q5JVR2|uniprotkb:Q68DI4|uniprotkb:Q9H2B8|uniprotkb:Q9HCZ7|ensembl:ENSP00000343313|ensembl:ENSP00000358072 psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym) psi-mi:atg5_human(display_long)|uniprotkb:APG5-like(gene name synonym)|uniprotkb:Apoptosis-specific protein(gene name synonym)|uniprotkb:ATG5(gene name)|psi-mi:ATG5(display_short)|uniprotkb:APG5L(gene name synonym)|uniprotkb:ASP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2938214|imex:IM-20521-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N refseq:NP_001273035.1|refseq:NP_001273036.1|refseq:NP_001273037.1|refseq:NP_001273040.1|refseq:NP_004840.1|dip:DIP-29758N|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009620"(response to fungus)|go:"GO:0016020"(membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0035973"(aggrephagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0048840"(otolith development)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060047"(heart contraction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR007239(Autophagy protein 5)|interpro:IPR042526|interpro:IPR042527|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:4TQ1|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8934903|reactome:R-HSA-936440|ensembl:ENSG00000057663(gene)|ensembl:ENST00000343245(transcript)|ensembl:ENST00000369076(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002718"(regulation of cytokine production involved in immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006501"(C-terminal protein lipidation) - - - figure legend:Fig S6E.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2010/10/13 2014/10/16 rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606 rogid:YqK4btJDQmY/dGxrmYxQmL+iAzc9606 intact-crc:23B88CF037EC1911|rigid:KnkW9evY88AB+LDMRfzj2EPjmlg false cyan fluorescent protein tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P37840 uniprotkb:Q8IZQ1 intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4 intact:EBI-1569256|uniprotkb:Q4W5K5|uniprotkb:Q6P0Q5|uniprotkb:Q8N1T2|uniprotkb:Q8NAV6|uniprotkb:Q96BS7|uniprotkb:Q96D33|uniprotkb:Q96N85|uniprotkb:Q9Y2J7|ensembl:ENSP00000295888 psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym) psi-mi:wdfy3_human(display_long)|uniprotkb:Autophagy-linked FYVE protein(gene name synonym)|uniprotkb:WDFY3(gene name)|psi-mi:WDFY3(display_short)|uniprotkb:KIAA0993(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2938214|imex:IM-20521-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N refseq:NP_055806.2|refseq:XP_011530065.1|refseq:XP_011530067.1|ensembl:ENSG00000163625(gene)|ensembl:ENST00000295888(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR036322|interpro:IPR036372|mint:Q8IZQ1|rcsb pdb:3WIM|rcsb pdb:6W9N - - - figure legend:Fig S6E.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2010/10/13 2014/10/16 rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606 rogid:yVIfhD/TU9JhrQR8WCChT4Jpi8c9606 intact-crc:23B88CF037EC1911|rigid:KnkW9evY88AB+LDMRfzj2EPjmlg false cyan fluorescent protein tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P37840 uniprotkb:Q9GZQ8 intact:EBI-985879|uniprotkb:Q13701|uniprotkb:Q4JHI3|uniprotkb:Q6IAU6|ensembl:ENSP00000338345|ensembl:ENSP00000378437|ensembl:ENSP00000378442|ensembl:ENSP00000422238|ensembl:ENSP00000426955|ensembl:ENSP00000500990|uniprotkb:A8K2A4 intact:EBI-373144|uniprotkb:Q6NW02|intact:EBI-28979688|ensembl:ENSP00000268607|ensembl:ENSP00000498476 psi-mi:syua_human(display_long)|uniprotkb:Non-A beta component of AD amyloid(gene name synonym)|uniprotkb:Non-A4 component of amyloid precursor(gene name synonym)|uniprotkb:SNCA(gene name)|psi-mi:SNCA(display_short)|uniprotkb:NACP(gene name synonym)|uniprotkb:PARK1(gene name synonym) psi-mi:mlp3b_human(display_long)|uniprotkb:MAP1LC3B(gene name)|psi-mi:MAP1LC3B(display_short)|uniprotkb:MAP1ALC3(gene name synonym)|uniprotkb:Microtubule-associated protein 1 light chain 3 beta(gene name synonym)|uniprotkb:MAP1A/MAP1B light chain 3 B(gene name synonym)|uniprotkb:MAP1 light chain 3-like protein 2(gene name synonym)|uniprotkb:Autophagy-related protein LC3 B(gene name synonym)|uniprotkb:Autophagy-related ubiquitin-like modifier LC3 B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2938214|imex:IM-20521-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011530510.1|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010517"(regulation of phospholipase activity)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016234"(inclusion body)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000145335(gene)|ensembl:ENST00000336904(transcript)|ensembl:ENST00000394986(transcript)|ensembl:ENST00000394991(transcript)|ensembl:ENST00000506244(transcript)|ensembl:ENST00000508895(transcript)|ensembl:ENST00000673718(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000149"(SNARE binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0003779"(actin binding)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006638"(neutral lipid metabolic process)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-977225|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032769"(negative regulation of monooxygenase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035543"(positive regulation of SNARE complex assembly)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0042393"(histone binding)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042493"|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050808"(synapse organization)|go:"GO:0050812"(regulation of acyl-CoA biosynthetic process)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051585"(negative regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051622"(negative regulation of norepinephrine uptake)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0098794"(postsynapse)|go:"GO:0099512"(supramolecular fiber)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|rcsb pdb:6LRQ|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902957"(negative regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903284"(positive regulation of glutathione peroxidase activity)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1904307"(response to desipramine)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001058(Synuclein)|interpro:IPR002460(Alpha-synuclein)|mint:P37840|rcsb pdb:1XQ8|rcsb pdb:2JN5|rcsb pdb:2KKW|rcsb pdb:2M55|rcsb pdb:2N0A|rcsb pdb:2X6M|rcsb pdb:6OSJ|rcsb pdb:6OSL|rcsb pdb:3Q25|rcsb pdb:3Q26|rcsb pdb:3Q27|rcsb pdb:3Q28|rcsb pdb:3Q29|rcsb pdb:6OSM|rcsb pdb:6PEO|rcsb pdb:6PES|rcsb pdb:4BXL|rcsb pdb:6RT0|rcsb pdb:6RTB|rcsb pdb:4R0U|rcsb pdb:6SST|rcsb pdb:6SSX|rcsb pdb:6UFR|rcsb pdb:6XYO|rcsb pdb:6XYP|rcsb pdb:6XYQ|rcsb pdb:4R0W|rcsb pdb:7C1D|rcsb pdb:7NCA|rcsb pdb:4RIK|rcsb pdb:4RIL|rcsb pdb:4ZNN|rcsb pdb:5CRW|rcsb pdb:6A6B|rcsb pdb:6CT7|rcsb pdb:6CU7|rcsb pdb:6CU8|rcsb pdb:6FLT|rcsb pdb:7NCG|rcsb pdb:6H6B|rcsb pdb:6I42|rcsb pdb:6L1T|rcsb pdb:6L1U|rcsb pdb:6L4S|rcsb pdb:7NCH|rcsb pdb:7NCI|rcsb pdb:7NCJ|rcsb pdb:7NCK|refseq:NP_000336.1|refseq:NP_001139526.1|refseq:NP_001139527.1|refseq:NP_009292.1|refseq:XP_016864051.1|refseq:XP_016864052.1|dip:DIP-35354N ensembl:ENSP00000268607|ensembl:ENSP00000498476|refseq:NP_073729.1|ensembl:ENSG00000140941(gene)|ensembl:ENST00000268607(transcript)|ensembl:ENST00000650688(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0008017"(microtubule binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0012505"(endomembrane system)|go:"GO:0016236"(macroautophagy)|go:"GO:0031090"(organelle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0097001"(ceramide binding)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR004241("Light chain 3 (LC3)")|interpro:IPR029071|mint:Q9GZQ8|rcsb pdb:1V49|rcsb pdb:2LUE|rcsb pdb:2N9X|rcsb pdb:2ZJD|rcsb pdb:3VTU|rcsb pdb:3VTV|rcsb pdb:3VTW|rcsb pdb:3WAO|rcsb pdb:3X0W|rcsb pdb:4WAA|rcsb pdb:5D94|rcsb pdb:5DCN|rcsb pdb:5GMV|rcsb pdb:5MS2|rcsb pdb:5MS5|rcsb pdb:5MS6|rcsb pdb:5V4K|rcsb pdb:5W9A|rcsb pdb:5XAC|rcsb pdb:5XAD|rcsb pdb:5XAE|rcsb pdb:6J04|rcsb pdb:6LAN|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8854214|reactome:R-HSA-8934903|reactome:R-HSA-9664873|reactome:R-HSA-9679504|reactome:R-HSA-9694676|dip:DIP-29760N - - - figure legend:Fig S6E.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2010/10/13 2014/10/16 rogid:q1l6uBs2lmhJEnVV56QYNhqlF+E9606 rogid:yUk3FGI9csW9DNlqWkewtqM2VN09606 intact-crc:23B88CF037EC1911|rigid:KnkW9evY88AB+LDMRfzj2EPjmlg false cyan fluorescent protein tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P42858 uniprotkb:Q8IZQ1 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 intact:EBI-1569256|uniprotkb:Q4W5K5|uniprotkb:Q6P0Q5|uniprotkb:Q8N1T2|uniprotkb:Q8NAV6|uniprotkb:Q96BS7|uniprotkb:Q96D33|uniprotkb:Q96N85|uniprotkb:Q9Y2J7|ensembl:ENSP00000295888 psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:wdfy3_human(display_long)|uniprotkb:Autophagy-linked FYVE protein(gene name synonym)|uniprotkb:WDFY3(gene name)|psi-mi:WDFY3(display_short)|uniprotkb:KIAA0993(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-2935311|imex:IM-20521-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N refseq:NP_055806.2|refseq:XP_011530065.1|refseq:XP_011530067.1|ensembl:ENSG00000163625(gene)|ensembl:ENST00000295888(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR036322|interpro:IPR036372|mint:Q8IZQ1|rcsb pdb:3WIM|rcsb pdb:6W9N go:"GO:0005829"(cytosol) - - figure legend:Fig 2B.|caution:"The reference given - Bjorkoy et al. 2005, states the construct used contained Htt amino acids 1-171. However this paper states the Htt sequence was taken from Exon 1 only, which is amino acids 1~90 (including the 21 glutamines residues according to P42858) - this would give a total number of ~140 amino acids used from Htt in this construct, rather than 171."|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2010/10/13 2014/10/16 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 rogid:yVIfhD/TU9JhrQR8WCChT4Jpi8c9606 intact-crc:E8FCA360D730AEDB|rigid:oRbN0FizZPRo7b7BHtWvEzcUUtM false flag tag:?-?|sufficient binding region:1-137..171 - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q8IZQ1 uniprotkb:Q9H1Y0 intact:EBI-1569256|uniprotkb:Q4W5K5|uniprotkb:Q6P0Q5|uniprotkb:Q8N1T2|uniprotkb:Q8NAV6|uniprotkb:Q96BS7|uniprotkb:Q96D33|uniprotkb:Q96N85|uniprotkb:Q9Y2J7|ensembl:ENSP00000295888 intact:EBI-1047414|uniprotkb:O60875|uniprotkb:Q5JVR2|uniprotkb:Q68DI4|uniprotkb:Q9H2B8|uniprotkb:Q9HCZ7|ensembl:ENSP00000343313|ensembl:ENSP00000358072 psi-mi:wdfy3_human(display_long)|uniprotkb:Autophagy-linked FYVE protein(gene name synonym)|uniprotkb:WDFY3(gene name)|psi-mi:WDFY3(display_short)|uniprotkb:KIAA0993(gene name synonym) psi-mi:atg5_human(display_long)|uniprotkb:APG5-like(gene name synonym)|uniprotkb:Apoptosis-specific protein(gene name synonym)|uniprotkb:ATG5(gene name)|psi-mi:ATG5(display_short)|uniprotkb:APG5L(gene name synonym)|uniprotkb:ASP(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-2935414|imex:IM-20521-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055806.2|refseq:XP_011530065.1|refseq:XP_011530067.1|ensembl:ENSG00000163625(gene)|ensembl:ENST00000295888(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR036322|interpro:IPR036372|mint:Q8IZQ1|rcsb pdb:3WIM|rcsb pdb:6W9N refseq:NP_001273035.1|refseq:NP_001273036.1|refseq:NP_001273037.1|refseq:NP_001273040.1|refseq:NP_004840.1|dip:DIP-29758N|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009620"(response to fungus)|go:"GO:0016020"(membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0035973"(aggrephagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0048840"(otolith development)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060047"(heart contraction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR007239(Autophagy protein 5)|interpro:IPR042526|interpro:IPR042527|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:4TQ1|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8934903|reactome:R-HSA-936440|ensembl:ENSG00000057663(gene)|ensembl:ENST00000343245(transcript)|ensembl:ENST00000369076(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002718"(regulation of cytokine production involved in immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006501"(C-terminal protein lipidation) - - - figure legend:Fig 4A panel 1.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2010/10/13 2014/10/16 rogid:yVIfhD/TU9JhrQR8WCChT4Jpi8c9606 rogid:YqK4btJDQmY/dGxrmYxQmL+iAzc9606 intact-crc:7981338346D3189C|rigid:82ryasy2E7Y2VhXu400syk+WlLQ false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P42858 uniprotkb:Q14596 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 intact:EBI-742698|uniprotkb:Q13173|uniprotkb:Q15026|uniprotkb:Q96GB6|uniprotkb:Q9NRF7|uniprotkb:Q5J7Q8|intact:EBI-2859623|ensembl:ENSP00000343479|ensembl:ENSP00000466667 psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:nbr1_human(display_long)|uniprotkb:Neighbor of BRCA1 gene 1 protein(gene name synonym)|uniprotkb:Membrane component chromosome 17 surface marker 2(gene name synonym)|uniprotkb:Protein 1A1-3B(gene name synonym)|uniprotkb:NBR1(gene name)|psi-mi:NBR1(display_short)|uniprotkb:1A13B(gene name synonym)|uniprotkb:KIAA0049(gene name synonym)|uniprotkb:M17S2(gene name synonym)|uniprotkb:Cell migration-inducing gene 19 protein(gene name synonym)|uniprotkb:MIG19(orf name) psi-mi:"MI:0663"(confocal microscopy) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-2936061|imex:IM-20521-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N refseq:NP_005890.2|refseq:NP_114068.1|ensembl:ENST00000341165(transcript)|ensembl:ENST00000590996(transcript)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016604"(nuclear body)|ensembl:ENSG00000188554(gene)|refseq:XP_011523115.1|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0031430"(M band)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0051019"(mitogen-activated protein kinase binding)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR032350|interpro:IPR033513|interpro:IPR034852|interpro:IPR043145|mint:Q14596|rcsb pdb:1WJ6|rcsb pdb:2BKF|rcsb pdb:2CP8|rcsb pdb:2G4S|rcsb pdb:2L8J|rcsb pdb:2MGW|rcsb pdb:2MJ5|rcsb pdb:4OLE|reactome:R-HSA-9664873|refseq:NP_001278500.1|refseq:NP_001278501.1|refseq:XP_016880131.1 - - - figure legend:Fig 5F.|caution:"The Htt sequence is stated to be \"exon1\", but the exact amino acid numbers are not given."|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2010/10/13 2014/10/16 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 rogid:rRlRq4sK4fkVQCliQ68/MIEOX6g9606 intact-crc:DC8AEACF751C0AEC|rigid:lf7uD9VvyTFBtCMR2e8ft+Lw+oE false cyan fluorescent protein tag:c-c|sufficient binding region:1-130..130 - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P42858 uniprotkb:Q13501 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 intact:EBI-307104|uniprotkb:Q13446|uniprotkb:Q9BUV7|uniprotkb:Q9BVS6|uniprotkb:Q9UEU1|uniprotkb:A6NFN7|uniprotkb:B2R661|uniprotkb:B3KUW5|intact:EBI-28976133|ensembl:ENSP00000374455 psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:sqstm_human(display_long)|uniprotkb:SQSTM1(gene name)|psi-mi:SQSTM1(display_short)|uniprotkb:ORCA(gene name synonym)|uniprotkb:OSIL(gene name synonym)|uniprotkb:Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa(gene name synonym)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym)|uniprotkb:EBI3-associated protein of 60 kDa(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-2936061|imex:IM-20521-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N ensembl:ENST00000360718|ensembl:ENSP00000353944|ensembl:ENSP00000374455|ensembl:ENSG00000161011(gene)|ensembl:ENST00000389805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016197"(endosomal transport)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR033741|go:"GO:0044753"(amphisome)|interpro:IPR034866|interpro:IPR043145|mint:Q13501|rcsb pdb:1Q02|rcsb pdb:2JY7|rcsb pdb:2JY8|rcsb pdb:2K0B|rcsb pdb:2KNV|go:"GO:0044754"(autolysosome)|rcsb pdb:4MJS|rcsb pdb:4UF8|rcsb pdb:4UF9|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:5YP7|rcsb pdb:5YP8|rcsb pdb:5YPA|rcsb pdb:5YPB|rcsb pdb:5YPC|rcsb pdb:5YPE|rcsb pdb:5YPF|rcsb pdb:5YPG|rcsb pdb:5YPH|rcsb pdb:6JM4|rcsb pdb:6KHZ|rcsb pdb:6MJ7|rcsb pdb:6TGY|rcsb pdb:6TH3|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-5205685|reactome:R-HSA-9020702|reactome:R-HSA-9664873|refseq:NP_001135770.1|refseq:NP_001135771.1|refseq:NP_003891.1|dip:DIP-34443N|refseq:XP_016865499.1 - - - figure legend:Fig 5F.|caution:"The Htt sequence is stated to be \"exon1\", but the exact amino acid numbers are not given."|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2010/10/13 2014/10/16 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 rogid:paIcBLmyiv1+D9QMym5MY3yc8MI9606 intact-crc:DC8AEACF751C0AEC|rigid:lf7uD9VvyTFBtCMR2e8ft+Lw+oE false cyan fluorescent protein tag:c-c|sufficient binding region:1-130..130 - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P42858 uniprotkb:Q8IZQ1 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 intact:EBI-1569256|uniprotkb:Q4W5K5|uniprotkb:Q6P0Q5|uniprotkb:Q8N1T2|uniprotkb:Q8NAV6|uniprotkb:Q96BS7|uniprotkb:Q96D33|uniprotkb:Q96N85|uniprotkb:Q9Y2J7|ensembl:ENSP00000295888 psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:wdfy3_human(display_long)|uniprotkb:Autophagy-linked FYVE protein(gene name synonym)|uniprotkb:WDFY3(gene name)|psi-mi:WDFY3(display_short)|uniprotkb:KIAA0993(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-2936061|imex:IM-20521-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N refseq:NP_055806.2|refseq:XP_011530065.1|refseq:XP_011530067.1|ensembl:ENSG00000163625(gene)|ensembl:ENST00000295888(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR036322|interpro:IPR036372|mint:Q8IZQ1|rcsb pdb:3WIM|rcsb pdb:6W9N - - - figure legend:Fig 5F.|caution:"The Htt sequence is stated to be \"exon1\", but the exact amino acid numbers are not given."|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2010/10/13 2014/10/16 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 rogid:yVIfhD/TU9JhrQR8WCChT4Jpi8c9606 intact-crc:DC8AEACF751C0AEC|rigid:lf7uD9VvyTFBtCMR2e8ft+Lw+oE false cyan fluorescent protein tag:c-c|sufficient binding region:1-130..130 - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P54253 uniprotkb:Q8IZQ1 intact:EBI-930964|uniprotkb:Q17S02|uniprotkb:Q9UJG2|uniprotkb:Q9Y4J1|ensembl:ENSP00000244769|ensembl:ENSP00000416360 intact:EBI-1569256|uniprotkb:Q4W5K5|uniprotkb:Q6P0Q5|uniprotkb:Q8N1T2|uniprotkb:Q8NAV6|uniprotkb:Q96BS7|uniprotkb:Q96D33|uniprotkb:Q96N85|uniprotkb:Q9Y2J7|ensembl:ENSP00000295888 psi-mi:atx1_human(display_long)|uniprotkb:ATXN1(gene name)|psi-mi:ATXN1(display_short)|uniprotkb:ATX1(gene name synonym)|uniprotkb:SCA1(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 1 protein(gene name synonym) psi-mi:wdfy3_human(display_long)|uniprotkb:Autophagy-linked FYVE protein(gene name synonym)|uniprotkb:WDFY3(gene name)|psi-mi:WDFY3(display_short)|uniprotkb:KIAA0993(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-2938194|imex:IM-20521-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000323.2|refseq:NP_001121636.1|dip:DIP-35353N|ensembl:ENSG00000124788(gene)|ensembl:ENST00000244769(transcript)|ensembl:ENST00000436367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006396"(RNA processing)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016363"(nuclear matrix)|go:"GO:0034046"("poly(G) binding")|go:"GO:0035176"(social behavior)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048856"(anatomical structure development)|go:"GO:0051168"(nuclear export)|interpro:IPR003652(Ataxin, AXH region)|interpro:IPR036096|interpro:IPR040172|interpro:IPR043404|mint:P54253|rcsb pdb:1OA8|rcsb pdb:2M41|rcsb pdb:4APT|rcsb pdb:4AQP|rcsb pdb:4J2J|rcsb pdb:4J2L|rcsb pdb:6QIU refseq:NP_055806.2|refseq:XP_011530065.1|refseq:XP_011530067.1|ensembl:ENSG00000163625(gene)|ensembl:ENST00000295888(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR036322|interpro:IPR036372|mint:Q8IZQ1|rcsb pdb:3WIM|rcsb pdb:6W9N go:"GO:0016604"(nuclear body) - - figure legend:Fig S 2C/D.|comment:"Ataxin1 (Q82) containing the nuclear localisation signal mutation K772T did not colocalize in the nucleus with Alfy, though some cytoplasmic colocalisation can be seen."|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2010/10/13 2014/10/16 rogid:DodgC3h3y3QNOd7da7+XB/MPPfQ9606 rogid:yVIfhD/TU9JhrQR8WCChT4Jpi8c9606 intact-crc:9081C8B3EB3DA9FE|rigid:asaYDtUvlAx897Bm/47GWXpJmhQ false mutation disrupting interaction:771-771|flag tag:?-? - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q8IZQ1 uniprotkb:Q9H1Y0 intact:EBI-1569256|uniprotkb:Q4W5K5|uniprotkb:Q6P0Q5|uniprotkb:Q8N1T2|uniprotkb:Q8NAV6|uniprotkb:Q96BS7|uniprotkb:Q96D33|uniprotkb:Q96N85|uniprotkb:Q9Y2J7|ensembl:ENSP00000295888 intact:EBI-1047414|uniprotkb:O60875|uniprotkb:Q5JVR2|uniprotkb:Q68DI4|uniprotkb:Q9H2B8|uniprotkb:Q9HCZ7|ensembl:ENSP00000343313|ensembl:ENSP00000358072 psi-mi:wdfy3_human(display_long)|uniprotkb:Autophagy-linked FYVE protein(gene name synonym)|uniprotkb:WDFY3(gene name)|psi-mi:WDFY3(display_short)|uniprotkb:KIAA0993(gene name synonym) psi-mi:atg5_human(display_long)|uniprotkb:APG5-like(gene name synonym)|uniprotkb:Apoptosis-specific protein(gene name synonym)|uniprotkb:ATG5(gene name)|psi-mi:ATG5(display_short)|uniprotkb:APG5L(gene name synonym)|uniprotkb:ASP(gene name synonym) psi-mi:"MI:0096"(pull down) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2935437|imex:IM-20521-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055806.2|refseq:XP_011530065.1|refseq:XP_011530067.1|ensembl:ENSG00000163625(gene)|ensembl:ENST00000295888(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR036322|interpro:IPR036372|mint:Q8IZQ1|rcsb pdb:3WIM|rcsb pdb:6W9N refseq:NP_001273035.1|refseq:NP_001273036.1|refseq:NP_001273037.1|refseq:NP_001273040.1|refseq:NP_004840.1|dip:DIP-29758N|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009620"(response to fungus)|go:"GO:0016020"(membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0035973"(aggrephagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0048840"(otolith development)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060047"(heart contraction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR007239(Autophagy protein 5)|interpro:IPR042526|interpro:IPR042527|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:4TQ1|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8934903|reactome:R-HSA-936440|ensembl:ENSG00000057663(gene)|ensembl:ENST00000343245(transcript)|ensembl:ENST00000369076(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002718"(regulation of cytokine production involved in immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006501"(C-terminal protein lipidation) - - - figure legend:Fig 4C.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2010/10/13 2014/10/16 rogid:yVIfhD/TU9JhrQR8WCChT4Jpi8c9606 rogid:YqK4btJDQmY/dGxrmYxQmL+iAzc9606 intact-crc:A795870F7AB70CC3|rigid:82ryasy2E7Y2VhXu400syk+WlLQ false maltose binding protein tag:?-?|sufficient binding region:2888-3526(IPR011046) glutathione s tranferase tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IZQ1 uniprotkb:Q9H1Y0 intact:EBI-1569256|uniprotkb:Q4W5K5|uniprotkb:Q6P0Q5|uniprotkb:Q8N1T2|uniprotkb:Q8NAV6|uniprotkb:Q96BS7|uniprotkb:Q96D33|uniprotkb:Q96N85|uniprotkb:Q9Y2J7|ensembl:ENSP00000295888 intact:EBI-1047414|uniprotkb:O60875|uniprotkb:Q5JVR2|uniprotkb:Q68DI4|uniprotkb:Q9H2B8|uniprotkb:Q9HCZ7|ensembl:ENSP00000343313|ensembl:ENSP00000358072 psi-mi:wdfy3_human(display_long)|uniprotkb:Autophagy-linked FYVE protein(gene name synonym)|uniprotkb:WDFY3(gene name)|psi-mi:WDFY3(display_short)|uniprotkb:KIAA0993(gene name synonym) psi-mi:atg5_human(display_long)|uniprotkb:APG5-like(gene name synonym)|uniprotkb:Apoptosis-specific protein(gene name synonym)|uniprotkb:ATG5(gene name)|psi-mi:ATG5(display_short)|uniprotkb:APG5L(gene name synonym)|uniprotkb:ASP(gene name synonym) psi-mi:"MI:0018"(two hybrid) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2935472|imex:IM-20521-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055806.2|refseq:XP_011530065.1|refseq:XP_011530067.1|ensembl:ENSG00000163625(gene)|ensembl:ENST00000295888(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR036322|interpro:IPR036372|mint:Q8IZQ1|rcsb pdb:3WIM|rcsb pdb:6W9N refseq:NP_001273035.1|refseq:NP_001273036.1|refseq:NP_001273037.1|refseq:NP_001273040.1|refseq:NP_004840.1|dip:DIP-29758N|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009620"(response to fungus)|go:"GO:0016020"(membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0035973"(aggrephagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0048840"(otolith development)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060047"(heart contraction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR007239(Autophagy protein 5)|interpro:IPR042526|interpro:IPR042527|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:4TQ1|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8934903|reactome:R-HSA-936440|ensembl:ENSG00000057663(gene)|ensembl:ENST00000343245(transcript)|ensembl:ENST00000369076(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002718"(regulation of cytokine production involved in immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006501"(C-terminal protein lipidation) - - - figure legend:Fig 4D.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2010/10/13 2014/10/16 rogid:yVIfhD/TU9JhrQR8WCChT4Jpi8c9606 rogid:YqK4btJDQmY/dGxrmYxQmL+iAzc9606 intact-crc:902352253A1F3108|rigid:82ryasy2E7Y2VhXu400syk+WlLQ false sufficient binding region:2981-3526(IPR011046) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99J83 uniprotkb:Q6VNB8 intact:EBI-2911848|ensembl:ENSMUSP00000044769 intact:EBI-2935491|ensembl:ENSMUSP00000052607|uniprotkb:Q8C8H7 psi-mi:atg5_mouse(display_long)|uniprotkb:Atg5(gene name)|psi-mi:Atg5(display_short)|uniprotkb:Apg5l(gene name synonym)|uniprotkb:APG5-like(gene name synonym) psi-mi:wdfy3_mouse(display_long)|uniprotkb:Wdfy3(gene name)|psi-mi:Wdfy3(display_short)|uniprotkb:Beach domain, WD repeat and FYVE domain-containing protein 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2935490|imex:IM-20521-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000038160(gene)|ensembl:ENSMUST00000039286(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002718"(regulation of cytokine production involved in immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006501"(C-terminal protein lipidation)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0009620"(response to fungus)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0035973"(aggrephagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0048840"(otolith development)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060047"(heart contraction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR007239(Autophagy protein 5)|interpro:IPR042526|interpro:IPR042527|mint:Q99J83|reactome:R-MMU-1632852|reactome:R-MMU-5205685|reactome:R-MMU-8934903|refseq:XP_011241410.1|refseq:NP_444299.1|refseq:NP_001300942.1|dip:DIP-46420N ensembl:ENSMUST00000053177(transcript)|go:"GO:0003831"(beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|ensembl:ENSMUSG00000043940(gene)|go:"GO:0046872"(metal ion binding)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036322|interpro:IPR036372|refseq:NP_766470.2 - - - figure legend:Fig 4E.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts) - 2010/10/13 2014/10/16 rogid:XNYb541lnGe1mjdDHei6DNhiNfk10090 rogid:usZZNZVZAzV8ubWsp5y077sivvI10090 intact-crc:40FEDEA1D922338D|rigid:5athTI34oHSzg6u7eSP2FvIFHmQ false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P42858 uniprotkb:Q9CQY1 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 intact:EBI-2911788|uniprotkb:Q3TKE5|uniprotkb:Q9D7Y5|ensembl:ENSMUSP00000038489 psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:atg12_mouse(display_long)|uniprotkb:Atg12(gene name)|psi-mi:Atg12(display_short)|uniprotkb:Apg12(gene name synonym)|uniprotkb:Apg12l(gene name synonym)|uniprotkb:Autophagy-related protein 12(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2936308|imex:IM-20521-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006501"(C-terminal protein lipidation)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0044804"(autophagy of nucleus)|interpro:IPR007242(Autophagy protein 12)|interpro:IPR029071|mint:Q9CQY1|reactome:R-MMU-1632852|reactome:R-MMU-5205685|reactome:R-MMU-8934903|ensembl:ENSMUSG00000032905(gene)|ensembl:ENSMUST00000035648(transcript)|refseq:NP_080493.2|dip:DIP-57729N - - - figure legend:Fig S6B.|caution:"The Htt sequence is stated to be \"exon1\", but the exact amino acid numbers are not given."|comment:Alfy can IP in the presence of polyQ proteins in ATG5 knockout cells.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts) - 2010/10/13 2014/10/16 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 rogid:VPDzzrLDhtPg3TwA3Qbhr5mB0CQ10090 intact-crc:50F5B808A5C9EF63|rigid:2XOdG5bpUcYgOW1/fl8jA2+cvtk false green fluorescent protein tag:?-?|sufficient binding region:1-140..140 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P42858 uniprotkb:Q99J83 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 intact:EBI-2911848|ensembl:ENSMUSP00000044769 psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:atg5_mouse(display_long)|uniprotkb:Atg5(gene name)|psi-mi:Atg5(display_short)|uniprotkb:Apg5l(gene name synonym)|uniprotkb:APG5-like(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2936308|imex:IM-20521-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N ensembl:ENSMUSG00000038160(gene)|ensembl:ENSMUST00000039286(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002718"(regulation of cytokine production involved in immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006501"(C-terminal protein lipidation)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0009620"(response to fungus)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0035973"(aggrephagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0048840"(otolith development)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060047"(heart contraction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR007239(Autophagy protein 5)|interpro:IPR042526|interpro:IPR042527|mint:Q99J83|reactome:R-MMU-1632852|reactome:R-MMU-5205685|reactome:R-MMU-8934903|refseq:XP_011241410.1|refseq:NP_444299.1|refseq:NP_001300942.1|dip:DIP-46420N - - - figure legend:Fig S6B.|caution:"The Htt sequence is stated to be \"exon1\", but the exact amino acid numbers are not given."|comment:Alfy can IP in the presence of polyQ proteins in ATG5 knockout cells.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts) - 2010/10/13 2014/10/16 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 rogid:XNYb541lnGe1mjdDHei6DNhiNfk10090 intact-crc:50F5B808A5C9EF63|rigid:2XOdG5bpUcYgOW1/fl8jA2+cvtk false green fluorescent protein tag:?-?|sufficient binding region:1-140..140 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P42858 uniprotkb:Q6VNB8 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 intact:EBI-2935491|ensembl:ENSMUSP00000052607|uniprotkb:Q8C8H7 psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:wdfy3_mouse(display_long)|uniprotkb:Wdfy3(gene name)|psi-mi:Wdfy3(display_short)|uniprotkb:Beach domain, WD repeat and FYVE domain-containing protein 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2936308|imex:IM-20521-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N ensembl:ENSMUST00000053177(transcript)|go:"GO:0003831"(beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|ensembl:ENSMUSG00000043940(gene)|go:"GO:0046872"(metal ion binding)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036322|interpro:IPR036372|refseq:NP_766470.2 - - - figure legend:Fig S6B.|caution:"The Htt sequence is stated to be \"exon1\", but the exact amino acid numbers are not given."|comment:Alfy can IP in the presence of polyQ proteins in ATG5 knockout cells.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts) - 2010/10/13 2014/10/16 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 rogid:usZZNZVZAzV8ubWsp5y077sivvI10090 intact-crc:50F5B808A5C9EF63|rigid:2XOdG5bpUcYgOW1/fl8jA2+cvtk false green fluorescent protein tag:?-?|sufficient binding region:1-140..140 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P42858 uniprotkb:Q9H1Y0 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 intact:EBI-1047414|uniprotkb:O60875|uniprotkb:Q5JVR2|uniprotkb:Q68DI4|uniprotkb:Q9H2B8|uniprotkb:Q9HCZ7|ensembl:ENSP00000343313|ensembl:ENSP00000358072 psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:atg5_human(display_long)|uniprotkb:APG5-like(gene name synonym)|uniprotkb:Apoptosis-specific protein(gene name synonym)|uniprotkb:ATG5(gene name)|psi-mi:ATG5(display_short)|uniprotkb:APG5L(gene name synonym)|uniprotkb:ASP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2935689|imex:IM-20521-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N refseq:NP_001273035.1|refseq:NP_001273036.1|refseq:NP_001273037.1|refseq:NP_001273040.1|refseq:NP_004840.1|dip:DIP-29758N|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009620"(response to fungus)|go:"GO:0016020"(membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0035973"(aggrephagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0048840"(otolith development)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060047"(heart contraction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR007239(Autophagy protein 5)|interpro:IPR042526|interpro:IPR042527|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:4TQ1|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8934903|reactome:R-HSA-936440|ensembl:ENSG00000057663(gene)|ensembl:ENST00000343245(transcript)|ensembl:ENST00000369076(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002718"(regulation of cytokine production involved in immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006501"(C-terminal protein lipidation) - - - figure legend:Fig 5A.|caution:"The Htt sequence is stated to be \"exon1\", but the exact amino acid numbers are not given."|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neuron)|taxid:9606(Human neurons) - 2010/10/13 2014/10/16 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 rogid:YqK4btJDQmY/dGxrmYxQmL+iAzc9606 intact-crc:DA257DA4258D0A92|rigid:97vhWCh75bInNtq2UyiD0QYn78U false green fluorescent protein tag:?-?|sufficient binding region:1-140..140 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P42858 uniprotkb:Q13501 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 intact:EBI-307104|uniprotkb:Q13446|uniprotkb:Q9BUV7|uniprotkb:Q9BVS6|uniprotkb:Q9UEU1|uniprotkb:A6NFN7|uniprotkb:B2R661|uniprotkb:B3KUW5|intact:EBI-28976133|ensembl:ENSP00000374455 psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:sqstm_human(display_long)|uniprotkb:SQSTM1(gene name)|psi-mi:SQSTM1(display_short)|uniprotkb:ORCA(gene name synonym)|uniprotkb:OSIL(gene name synonym)|uniprotkb:Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa(gene name synonym)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym)|uniprotkb:EBI3-associated protein of 60 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2935689|imex:IM-20521-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N ensembl:ENST00000360718|ensembl:ENSP00000353944|ensembl:ENSP00000374455|ensembl:ENSG00000161011(gene)|ensembl:ENST00000389805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016197"(endosomal transport)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR033741|go:"GO:0044753"(amphisome)|interpro:IPR034866|interpro:IPR043145|mint:Q13501|rcsb pdb:1Q02|rcsb pdb:2JY7|rcsb pdb:2JY8|rcsb pdb:2K0B|rcsb pdb:2KNV|go:"GO:0044754"(autolysosome)|rcsb pdb:4MJS|rcsb pdb:4UF8|rcsb pdb:4UF9|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:5YP7|rcsb pdb:5YP8|rcsb pdb:5YPA|rcsb pdb:5YPB|rcsb pdb:5YPC|rcsb pdb:5YPE|rcsb pdb:5YPF|rcsb pdb:5YPG|rcsb pdb:5YPH|rcsb pdb:6JM4|rcsb pdb:6KHZ|rcsb pdb:6MJ7|rcsb pdb:6TGY|rcsb pdb:6TH3|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-5205685|reactome:R-HSA-9020702|reactome:R-HSA-9664873|refseq:NP_001135770.1|refseq:NP_001135771.1|refseq:NP_003891.1|dip:DIP-34443N|refseq:XP_016865499.1 - - - figure legend:Fig 5A.|caution:"The Htt sequence is stated to be \"exon1\", but the exact amino acid numbers are not given."|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neuron)|taxid:9606(Human neurons) - 2010/10/13 2014/10/16 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 rogid:paIcBLmyiv1+D9QMym5MY3yc8MI9606 intact-crc:DA257DA4258D0A92|rigid:97vhWCh75bInNtq2UyiD0QYn78U false green fluorescent protein tag:?-?|sufficient binding region:1-140..140 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P42858 uniprotkb:Q9GZQ8 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 intact:EBI-373144|uniprotkb:Q6NW02|intact:EBI-28979688|ensembl:ENSP00000268607|ensembl:ENSP00000498476 psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:mlp3b_human(display_long)|uniprotkb:MAP1LC3B(gene name)|psi-mi:MAP1LC3B(display_short)|uniprotkb:MAP1ALC3(gene name synonym)|uniprotkb:Microtubule-associated protein 1 light chain 3 beta(gene name synonym)|uniprotkb:MAP1A/MAP1B light chain 3 B(gene name synonym)|uniprotkb:MAP1 light chain 3-like protein 2(gene name synonym)|uniprotkb:Autophagy-related protein LC3 B(gene name synonym)|uniprotkb:Autophagy-related ubiquitin-like modifier LC3 B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2935689|imex:IM-20521-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N ensembl:ENSP00000268607|ensembl:ENSP00000498476|refseq:NP_073729.1|ensembl:ENSG00000140941(gene)|ensembl:ENST00000268607(transcript)|ensembl:ENST00000650688(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0008017"(microtubule binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0012505"(endomembrane system)|go:"GO:0016236"(macroautophagy)|go:"GO:0031090"(organelle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0097001"(ceramide binding)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR004241("Light chain 3 (LC3)")|interpro:IPR029071|mint:Q9GZQ8|rcsb pdb:1V49|rcsb pdb:2LUE|rcsb pdb:2N9X|rcsb pdb:2ZJD|rcsb pdb:3VTU|rcsb pdb:3VTV|rcsb pdb:3VTW|rcsb pdb:3WAO|rcsb pdb:3X0W|rcsb pdb:4WAA|rcsb pdb:5D94|rcsb pdb:5DCN|rcsb pdb:5GMV|rcsb pdb:5MS2|rcsb pdb:5MS5|rcsb pdb:5MS6|rcsb pdb:5V4K|rcsb pdb:5W9A|rcsb pdb:5XAC|rcsb pdb:5XAD|rcsb pdb:5XAE|rcsb pdb:6J04|rcsb pdb:6LAN|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8854214|reactome:R-HSA-8934903|reactome:R-HSA-9664873|reactome:R-HSA-9679504|reactome:R-HSA-9694676|dip:DIP-29760N - - - figure legend:Fig 5A.|caution:"The Htt sequence is stated to be \"exon1\", but the exact amino acid numbers are not given."|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neuron)|taxid:9606(Human neurons) - 2010/10/13 2014/10/16 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 rogid:yUk3FGI9csW9DNlqWkewtqM2VN09606 intact-crc:DA257DA4258D0A92|rigid:97vhWCh75bInNtq2UyiD0QYn78U false green fluorescent protein tag:?-?|sufficient binding region:1-140..140 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P42858 uniprotkb:Q8IZQ1 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 intact:EBI-1569256|uniprotkb:Q4W5K5|uniprotkb:Q6P0Q5|uniprotkb:Q8N1T2|uniprotkb:Q8NAV6|uniprotkb:Q96BS7|uniprotkb:Q96D33|uniprotkb:Q96N85|uniprotkb:Q9Y2J7|ensembl:ENSP00000295888 psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:wdfy3_human(display_long)|uniprotkb:Autophagy-linked FYVE protein(gene name synonym)|uniprotkb:WDFY3(gene name)|psi-mi:WDFY3(display_short)|uniprotkb:KIAA0993(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2935689|imex:IM-20521-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N refseq:NP_055806.2|refseq:XP_011530065.1|refseq:XP_011530067.1|ensembl:ENSG00000163625(gene)|ensembl:ENST00000295888(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR036322|interpro:IPR036372|mint:Q8IZQ1|rcsb pdb:3WIM|rcsb pdb:6W9N - - - figure legend:Fig 5A.|caution:"The Htt sequence is stated to be \"exon1\", but the exact amino acid numbers are not given."|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-neuron)|taxid:9606(Human neurons) - 2010/10/13 2014/10/16 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 rogid:yVIfhD/TU9JhrQR8WCChT4Jpi8c9606 intact-crc:DA257DA4258D0A92|rigid:97vhWCh75bInNtq2UyiD0QYn78U false green fluorescent protein tag:?-?|sufficient binding region:1-140..140 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IZQ1 uniprotkb:P42858 intact:EBI-1569256|uniprotkb:Q4W5K5|uniprotkb:Q6P0Q5|uniprotkb:Q8N1T2|uniprotkb:Q8NAV6|uniprotkb:Q96BS7|uniprotkb:Q96D33|uniprotkb:Q96N85|uniprotkb:Q9Y2J7|ensembl:ENSP00000295888 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 psi-mi:wdfy3_human(display_long)|uniprotkb:Autophagy-linked FYVE protein(gene name synonym)|uniprotkb:WDFY3(gene name)|psi-mi:WDFY3(display_short)|uniprotkb:KIAA0993(gene name synonym) psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2935768|imex:IM-20521-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055806.2|refseq:XP_011530065.1|refseq:XP_011530067.1|ensembl:ENSG00000163625(gene)|ensembl:ENST00000295888(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR036322|interpro:IPR036372|mint:Q8IZQ1|rcsb pdb:3WIM|rcsb pdb:6W9N ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N - - - figure legend:Fig 5C.|comment:Immunoprecipitation with Alfy revealed that endogenous Htt comes down with Alfy only in HD patient samples.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-cls)|taxid:9606("Homo sapiens fibroblast cell line (GM03318)") - 2010/10/13 2014/10/16 rogid:yVIfhD/TU9JhrQR8WCChT4Jpi8c9606 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 intact-crc:127575DDDDC1327E|rigid:97vhWCh75bInNtq2UyiD0QYn78U false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IZQ1 uniprotkb:Q13501 intact:EBI-1569256|uniprotkb:Q4W5K5|uniprotkb:Q6P0Q5|uniprotkb:Q8N1T2|uniprotkb:Q8NAV6|uniprotkb:Q96BS7|uniprotkb:Q96D33|uniprotkb:Q96N85|uniprotkb:Q9Y2J7|ensembl:ENSP00000295888 intact:EBI-307104|uniprotkb:Q13446|uniprotkb:Q9BUV7|uniprotkb:Q9BVS6|uniprotkb:Q9UEU1|uniprotkb:A6NFN7|uniprotkb:B2R661|uniprotkb:B3KUW5|intact:EBI-28976133|ensembl:ENSP00000374455 psi-mi:wdfy3_human(display_long)|uniprotkb:Autophagy-linked FYVE protein(gene name synonym)|uniprotkb:WDFY3(gene name)|psi-mi:WDFY3(display_short)|uniprotkb:KIAA0993(gene name synonym) psi-mi:sqstm_human(display_long)|uniprotkb:SQSTM1(gene name)|psi-mi:SQSTM1(display_short)|uniprotkb:ORCA(gene name synonym)|uniprotkb:OSIL(gene name synonym)|uniprotkb:Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa(gene name synonym)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym)|uniprotkb:EBI3-associated protein of 60 kDa(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2935768|imex:IM-20521-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055806.2|refseq:XP_011530065.1|refseq:XP_011530067.1|ensembl:ENSG00000163625(gene)|ensembl:ENST00000295888(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR036322|interpro:IPR036372|mint:Q8IZQ1|rcsb pdb:3WIM|rcsb pdb:6W9N ensembl:ENST00000360718|ensembl:ENSP00000353944|ensembl:ENSP00000374455|ensembl:ENSG00000161011(gene)|ensembl:ENST00000389805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016197"(endosomal transport)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR033741|go:"GO:0044753"(amphisome)|interpro:IPR034866|interpro:IPR043145|mint:Q13501|rcsb pdb:1Q02|rcsb pdb:2JY7|rcsb pdb:2JY8|rcsb pdb:2K0B|rcsb pdb:2KNV|go:"GO:0044754"(autolysosome)|rcsb pdb:4MJS|rcsb pdb:4UF8|rcsb pdb:4UF9|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:5YP7|rcsb pdb:5YP8|rcsb pdb:5YPA|rcsb pdb:5YPB|rcsb pdb:5YPC|rcsb pdb:5YPE|rcsb pdb:5YPF|rcsb pdb:5YPG|rcsb pdb:5YPH|rcsb pdb:6JM4|rcsb pdb:6KHZ|rcsb pdb:6MJ7|rcsb pdb:6TGY|rcsb pdb:6TH3|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-5205685|reactome:R-HSA-9020702|reactome:R-HSA-9664873|refseq:NP_001135770.1|refseq:NP_001135771.1|refseq:NP_003891.1|dip:DIP-34443N|refseq:XP_016865499.1 - - - figure legend:Fig 5C.|comment:Immunoprecipitation with Alfy revealed that endogenous Htt comes down with Alfy only in HD patient samples.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-cls)|taxid:9606("Homo sapiens fibroblast cell line (GM03318)") - 2010/10/13 2014/10/16 rogid:yVIfhD/TU9JhrQR8WCChT4Jpi8c9606 rogid:paIcBLmyiv1+D9QMym5MY3yc8MI9606 intact-crc:127575DDDDC1327E|rigid:97vhWCh75bInNtq2UyiD0QYn78U false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IZQ1 uniprotkb:Q9GZQ8 intact:EBI-1569256|uniprotkb:Q4W5K5|uniprotkb:Q6P0Q5|uniprotkb:Q8N1T2|uniprotkb:Q8NAV6|uniprotkb:Q96BS7|uniprotkb:Q96D33|uniprotkb:Q96N85|uniprotkb:Q9Y2J7|ensembl:ENSP00000295888 intact:EBI-373144|uniprotkb:Q6NW02|intact:EBI-28979688|ensembl:ENSP00000268607|ensembl:ENSP00000498476 psi-mi:wdfy3_human(display_long)|uniprotkb:Autophagy-linked FYVE protein(gene name synonym)|uniprotkb:WDFY3(gene name)|psi-mi:WDFY3(display_short)|uniprotkb:KIAA0993(gene name synonym) psi-mi:mlp3b_human(display_long)|uniprotkb:MAP1LC3B(gene name)|psi-mi:MAP1LC3B(display_short)|uniprotkb:MAP1ALC3(gene name synonym)|uniprotkb:Microtubule-associated protein 1 light chain 3 beta(gene name synonym)|uniprotkb:MAP1A/MAP1B light chain 3 B(gene name synonym)|uniprotkb:MAP1 light chain 3-like protein 2(gene name synonym)|uniprotkb:Autophagy-related protein LC3 B(gene name synonym)|uniprotkb:Autophagy-related ubiquitin-like modifier LC3 B(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2935768|imex:IM-20521-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055806.2|refseq:XP_011530065.1|refseq:XP_011530067.1|ensembl:ENSG00000163625(gene)|ensembl:ENST00000295888(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR036322|interpro:IPR036372|mint:Q8IZQ1|rcsb pdb:3WIM|rcsb pdb:6W9N ensembl:ENSP00000268607|ensembl:ENSP00000498476|refseq:NP_073729.1|ensembl:ENSG00000140941(gene)|ensembl:ENST00000268607(transcript)|ensembl:ENST00000650688(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0008017"(microtubule binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0012505"(endomembrane system)|go:"GO:0016236"(macroautophagy)|go:"GO:0031090"(organelle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0097001"(ceramide binding)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR004241("Light chain 3 (LC3)")|interpro:IPR029071|mint:Q9GZQ8|rcsb pdb:1V49|rcsb pdb:2LUE|rcsb pdb:2N9X|rcsb pdb:2ZJD|rcsb pdb:3VTU|rcsb pdb:3VTV|rcsb pdb:3VTW|rcsb pdb:3WAO|rcsb pdb:3X0W|rcsb pdb:4WAA|rcsb pdb:5D94|rcsb pdb:5DCN|rcsb pdb:5GMV|rcsb pdb:5MS2|rcsb pdb:5MS5|rcsb pdb:5MS6|rcsb pdb:5V4K|rcsb pdb:5W9A|rcsb pdb:5XAC|rcsb pdb:5XAD|rcsb pdb:5XAE|rcsb pdb:6J04|rcsb pdb:6LAN|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8854214|reactome:R-HSA-8934903|reactome:R-HSA-9664873|reactome:R-HSA-9679504|reactome:R-HSA-9694676|dip:DIP-29760N - - - figure legend:Fig 5C.|comment:Immunoprecipitation with Alfy revealed that endogenous Htt comes down with Alfy only in HD patient samples.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-cls)|taxid:9606("Homo sapiens fibroblast cell line (GM03318)") - 2010/10/13 2014/10/16 rogid:yVIfhD/TU9JhrQR8WCChT4Jpi8c9606 rogid:yUk3FGI9csW9DNlqWkewtqM2VN09606 intact-crc:127575DDDDC1327E|rigid:97vhWCh75bInNtq2UyiD0QYn78U false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IZQ1 uniprotkb:Q9H1Y0 intact:EBI-1569256|uniprotkb:Q4W5K5|uniprotkb:Q6P0Q5|uniprotkb:Q8N1T2|uniprotkb:Q8NAV6|uniprotkb:Q96BS7|uniprotkb:Q96D33|uniprotkb:Q96N85|uniprotkb:Q9Y2J7|ensembl:ENSP00000295888 intact:EBI-1047414|uniprotkb:O60875|uniprotkb:Q5JVR2|uniprotkb:Q68DI4|uniprotkb:Q9H2B8|uniprotkb:Q9HCZ7|ensembl:ENSP00000343313|ensembl:ENSP00000358072 psi-mi:wdfy3_human(display_long)|uniprotkb:Autophagy-linked FYVE protein(gene name synonym)|uniprotkb:WDFY3(gene name)|psi-mi:WDFY3(display_short)|uniprotkb:KIAA0993(gene name synonym) psi-mi:atg5_human(display_long)|uniprotkb:APG5-like(gene name synonym)|uniprotkb:Apoptosis-specific protein(gene name synonym)|uniprotkb:ATG5(gene name)|psi-mi:ATG5(display_short)|uniprotkb:APG5L(gene name synonym)|uniprotkb:ASP(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2935768|imex:IM-20521-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055806.2|refseq:XP_011530065.1|refseq:XP_011530067.1|ensembl:ENSG00000163625(gene)|ensembl:ENST00000295888(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR036322|interpro:IPR036372|mint:Q8IZQ1|rcsb pdb:3WIM|rcsb pdb:6W9N refseq:NP_001273035.1|refseq:NP_001273036.1|refseq:NP_001273037.1|refseq:NP_001273040.1|refseq:NP_004840.1|dip:DIP-29758N|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009620"(response to fungus)|go:"GO:0016020"(membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0035973"(aggrephagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0048840"(otolith development)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060047"(heart contraction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR007239(Autophagy protein 5)|interpro:IPR042526|interpro:IPR042527|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:4TQ1|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8934903|reactome:R-HSA-936440|ensembl:ENSG00000057663(gene)|ensembl:ENST00000343245(transcript)|ensembl:ENST00000369076(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002718"(regulation of cytokine production involved in immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006501"(C-terminal protein lipidation) - - - figure legend:Fig 5C.|comment:Immunoprecipitation with Alfy revealed that endogenous Htt comes down with Alfy only in HD patient samples.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-cls)|taxid:9606("Homo sapiens fibroblast cell line (GM03318)") - 2010/10/13 2014/10/16 rogid:yVIfhD/TU9JhrQR8WCChT4Jpi8c9606 rogid:YqK4btJDQmY/dGxrmYxQmL+iAzc9606 intact-crc:127575DDDDC1327E|rigid:97vhWCh75bInNtq2UyiD0QYn78U false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P42858 uniprotkb:O08623 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 intact:EBI-2935892|ensembl:ENSRNOP00000056021|uniprotkb:Q8CH59 psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:sqstm_rat(display_long)|uniprotkb:Sqstm1(gene name)|psi-mi:Sqstm1(display_short)|uniprotkb:Zip(gene name synonym)|uniprotkb:Protein kinase C-zeta-interacting protein(gene name synonym)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2935861|imex:IM-20521-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N ensembl:ENSRNOG00000003147(gene)|ensembl:ENSRNOT00000059255(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR033741|interpro:IPR034866|interpro:IPR043145|mint:O08623|rcsb pdb:2K6Q|rcsb pdb:2KKC|rcsb pdb:2KTR|reactome:R-RNO-205043|reactome:R-RNO-209543|reactome:R-RNO-209560|reactome:R-RNO-5205685|reactome:R-RNO-9020702|reactome:R-RNO-9664873|go:"GO:0098780"(response to mitochondrial depolarisation)|rgd:69287|refseq:NP_787037.2|refseq:NP_853528.1|refseq:XP_006246275.1 - - - figure legend:Fig 5E.|caution:"The Htt sequence is stated to be \"exon1\", but the exact amino acid numbers are not given."|comment:"Alfie knockdown (sh-Alfy) diminished the interaction with Atg5, and a diminished amount of LC3 was present in the complex."|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-neuron)|taxid:10116(Rattus norvegicus neuronal cell) - 2010/10/13 2014/10/16 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 rogid:pKHXjz01l4PLf+w2rdWahLgWEpw10116 intact-crc:1E6FA5A5FE9FC1E2|rigid:OEsMdFBY/hvBoKpQ+SAmJQSui50 false green fluorescent protein tag:?-?|sufficient binding region:1-140..140 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P42858 intact:EBI-2935946 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 - psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:d4a7d8_rat(display_short)|psi-mi:EBI-2935946(display_long)|uniprotkb:Wdfy3(gene name)|psi-mi:Wdfy3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2935861|imex:IM-20521-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N uniprotkb:D4A7D8(uniprot-removed-ac) - - no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. figure legend:Fig 5E.|caution:"The Htt sequence is stated to be \"exon1\", but the exact amino acid numbers are not given."|comment:"Alfie knockdown (sh-Alfy) diminished the interaction with Atg5, and a diminished amount of LC3 was present in the complex."|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-neuron)|taxid:10116(Rattus norvegicus neuronal cell) - 2010/10/13 2014/10/16 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 rogid:sP26Fqsu81fLTQ4KNvmNloVamno10116 intact-crc:1E6FA5A5FE9FC1E2|rigid:OEsMdFBY/hvBoKpQ+SAmJQSui50 false green fluorescent protein tag:?-?|sufficient binding region:1-140..140 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P42858 uniprotkb:Q3MQ06 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 intact:EBI-2935883 psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:atg5_rat(display_long)|uniprotkb:Atg5(gene name)|psi-mi:Atg5(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2935861|imex:IM-20521-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002718"(regulation of cytokine production involved in immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005930"(axoneme)|go:"GO:0006501"(C-terminal protein lipidation)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009620"(response to fungus)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0030424"(axon)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0035973"(aggrephagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060047"(heart contraction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:1902617"(response to fluoride)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:0048840"(otolith development)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR007239(Autophagy protein 5)|rgd:1359580|reactome:R-RNO-1632852|reactome:R-RNO-5205685|reactome:R-RNO-8934903|interpro:IPR042526|interpro:IPR042527 - - - figure legend:Fig 5E.|caution:"The Htt sequence is stated to be \"exon1\", but the exact amino acid numbers are not given."|comment:"Alfie knockdown (sh-Alfy) diminished the interaction with Atg5, and a diminished amount of LC3 was present in the complex."|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-neuron)|taxid:10116(Rattus norvegicus neuronal cell) - 2010/10/13 2014/10/16 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 rogid:NtfLlh6YsenKYc4paZ+fr9t3Bzs10116 intact-crc:1E6FA5A5FE9FC1E2|rigid:OEsMdFBY/hvBoKpQ+SAmJQSui50 false green fluorescent protein tag:?-?|sufficient binding region:1-140..140 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P42858 uniprotkb:Q62625 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 intact:EBI-2935980|ensembl:ENSRNOP00000062130|uniprotkb:Q6XVN7 psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:mlp3b_rat(display_long)|uniprotkb:Map1lc3b(gene name)|psi-mi:Map1lc3b(display_short)|uniprotkb:Map1alc3(gene name synonym)|uniprotkb:Map1lc3(gene name synonym)|uniprotkb:Autophagy-related protein LC3 B(gene name synonym)|uniprotkb:Autophagy-related ubiquitin-like modifier LC3 B(gene name synonym)|uniprotkb:MAP1 light chain 3-like protein 2(gene name synonym)|uniprotkb:MAP1A/MAP1B light chain 3 B(gene name synonym)|uniprotkb:Microtubule-associated protein 1 light chain 3 beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-2935861|imex:IM-20521-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0008017"(microtubule binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0012505"(endomembrane system)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044754"(autolysosome)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR004241("Light chain 3 (LC3)")|interpro:IPR029071|rcsb pdb:1UGM|rcsb pdb:2K6Q|rcsb pdb:2Z0D|rcsb pdb:2Z0E|rcsb pdb:2ZZP|reactome:R-RNO-1632852|reactome:R-RNO-5205685|reactome:R-RNO-8854214|reactome:R-RNO-8934903|reactome:R-RNO-9664873|go:"GO:0000423"(mitophagy)|ensembl:ENSRNOG00000017905(gene)|ensembl:ENSRNOT00000067141(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000422"(autophagy of mitochondrion)|rgd:621315|refseq:NP_074058.2|refseq:XP_017456840.1 - - - figure legend:Fig 5E.|caution:"The Htt sequence is stated to be \"exon1\", but the exact amino acid numbers are not given."|comment:"Alfie knockdown (sh-Alfy) diminished the interaction with Atg5, and a diminished amount of LC3 was present in the complex."|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-neuron)|taxid:10116(Rattus norvegicus neuronal cell) - 2010/10/13 2014/10/16 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 rogid:5KiMxcCBOwyxOHUK7zRN2Yte64g10116 intact-crc:1E6FA5A5FE9FC1E2|rigid:OEsMdFBY/hvBoKpQ+SAmJQSui50 false green fluorescent protein tag:?-?|sufficient binding region:1-140..140 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IZQ1 uniprotkb:P42858 intact:EBI-1569256|uniprotkb:Q4W5K5|uniprotkb:Q6P0Q5|uniprotkb:Q8N1T2|uniprotkb:Q8NAV6|uniprotkb:Q96BS7|uniprotkb:Q96D33|uniprotkb:Q96N85|uniprotkb:Q9Y2J7|ensembl:ENSP00000295888 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 psi-mi:wdfy3_human(display_long)|uniprotkb:Autophagy-linked FYVE protein(gene name synonym)|uniprotkb:WDFY3(gene name)|psi-mi:WDFY3(display_short)|uniprotkb:KIAA0993(gene name synonym) psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-2936142|imex:IM-20521-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055806.2|refseq:XP_011530065.1|refseq:XP_011530067.1|ensembl:ENSG00000163625(gene)|ensembl:ENST00000295888(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR036322|interpro:IPR036372|mint:Q8IZQ1|rcsb pdb:3WIM|rcsb pdb:6W9N ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0005634"(nucleus) - - figure legend:Fig 6A, S7C.|caution:"The Htt sequence is stated to be \"exon1\", but the exact amino acid numbers are not given. The number of glutamines is stated to be 79 on the image, but 72 on the image legend."|comment:Expression of Alfy2981-3526 led to a significant reduction in the aggregate load in the neurons. Overexpression of the full-length 400 kDa Alfy was very difficult to achieve, but in the few cells that were successfully transfected, the frequency of inclusions was fewer, as for Alfy2981-3526.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-brain-cortex)|taxid:10116(Rattus norvegicus brain cortex) - 2010/10/13 2014/10/16 rogid:yVIfhD/TU9JhrQR8WCChT4Jpi8c9606 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 intact-crc:C54F91746136015D|rigid:oRbN0FizZPRo7b7BHtWvEzcUUtM false fluorophore:?-? green fluorescent protein tag:?-?|sufficient binding region:1-150..150 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:P42858 uniprotkb:Q62625 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 intact:EBI-2935980|ensembl:ENSRNOP00000062130|uniprotkb:Q6XVN7 psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:mlp3b_rat(display_long)|uniprotkb:Map1lc3b(gene name)|psi-mi:Map1lc3b(display_short)|uniprotkb:Map1alc3(gene name synonym)|uniprotkb:Map1lc3(gene name synonym)|uniprotkb:Autophagy-related protein LC3 B(gene name synonym)|uniprotkb:Autophagy-related ubiquitin-like modifier LC3 B(gene name synonym)|uniprotkb:MAP1 light chain 3-like protein 2(gene name synonym)|uniprotkb:MAP1A/MAP1B light chain 3 B(gene name synonym)|uniprotkb:Microtubule-associated protein 1 light chain 3 beta(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-2936228|imex:IM-20521-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0008017"(microtubule binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0012505"(endomembrane system)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044754"(autolysosome)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0097352"(autophagosome maturation)|interpro:IPR004241("Light chain 3 (LC3)")|interpro:IPR029071|rcsb pdb:1UGM|rcsb pdb:2K6Q|rcsb pdb:2Z0D|rcsb pdb:2Z0E|rcsb pdb:2ZZP|reactome:R-RNO-1632852|reactome:R-RNO-5205685|reactome:R-RNO-8854214|reactome:R-RNO-8934903|reactome:R-RNO-9664873|go:"GO:0000423"(mitophagy)|ensembl:ENSRNOG00000017905(gene)|ensembl:ENSRNOT00000067141(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000422"(autophagy of mitochondrion)|rgd:621315|refseq:NP_074058.2|refseq:XP_017456840.1 go:"GO:0005829"(cytosol) - - figure legend:Fig S1A.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2010/10/13 2014/10/16 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 rogid:5KiMxcCBOwyxOHUK7zRN2Yte64g10116 intact-crc:609880396B211315|rigid:r/9iWaoc601orDbRm0LSfcngNrU false flag tag:?-?|sufficient binding region:1-171 green fluorescent protein tag:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P42858 uniprotkb:Q8IZQ1 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 intact:EBI-1569256|uniprotkb:Q4W5K5|uniprotkb:Q6P0Q5|uniprotkb:Q8N1T2|uniprotkb:Q8NAV6|uniprotkb:Q96BS7|uniprotkb:Q96D33|uniprotkb:Q96N85|uniprotkb:Q9Y2J7|ensembl:ENSP00000295888 psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:wdfy3_human(display_long)|uniprotkb:Autophagy-linked FYVE protein(gene name synonym)|uniprotkb:WDFY3(gene name)|psi-mi:WDFY3(display_short)|uniprotkb:KIAA0993(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-2936228|imex:IM-20521-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N refseq:NP_055806.2|refseq:XP_011530065.1|refseq:XP_011530067.1|ensembl:ENSG00000163625(gene)|ensembl:ENST00000295888(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR036322|interpro:IPR036372|mint:Q8IZQ1|rcsb pdb:3WIM|rcsb pdb:6W9N go:"GO:0005829"(cytosol) - - figure legend:Fig S1A.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2010/10/13 2014/10/16 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 rogid:yVIfhD/TU9JhrQR8WCChT4Jpi8c9606 intact-crc:609880396B211315|rigid:r/9iWaoc601orDbRm0LSfcngNrU false flag tag:?-?|sufficient binding region:1-171 - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q9H1Y0 uniprotkb:P42858 intact:EBI-1047414|uniprotkb:O60875|uniprotkb:Q5JVR2|uniprotkb:Q68DI4|uniprotkb:Q9H2B8|uniprotkb:Q9HCZ7|ensembl:ENSP00000343313|ensembl:ENSP00000358072 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 psi-mi:atg5_human(display_long)|uniprotkb:APG5-like(gene name synonym)|uniprotkb:Apoptosis-specific protein(gene name synonym)|uniprotkb:ATG5(gene name)|psi-mi:ATG5(display_short)|uniprotkb:APG5L(gene name synonym)|uniprotkb:ASP(gene name synonym) psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-2936271|imex:IM-20521-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273035.1|refseq:NP_001273036.1|refseq:NP_001273037.1|refseq:NP_001273040.1|refseq:NP_004840.1|dip:DIP-29758N|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009620"(response to fungus)|go:"GO:0016020"(membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0035973"(aggrephagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0048840"(otolith development)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060047"(heart contraction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR007239(Autophagy protein 5)|interpro:IPR042526|interpro:IPR042527|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:4TQ1|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8934903|reactome:R-HSA-936440|ensembl:ENSG00000057663(gene)|ensembl:ENST00000343245(transcript)|ensembl:ENST00000369076(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002718"(regulation of cytokine production involved in immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006501"(C-terminal protein lipidation) ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N - - - figure legend:Fig S5A.|caution:"The Htt sequence is stated to be \"exon1\", but the exact amino acid numbers are not given."|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2010/10/13 2014/10/16 rogid:YqK4btJDQmY/dGxrmYxQmL+iAzc9606 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 intact-crc:9EF9B8F2F6534EE5|rigid:+AJyhmi7Qcoqyr48S/htvPACTxI false - cyan fluorescent protein tag:c-c|sufficient binding region:1-170..170 - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q9H1Y0 uniprotkb:Q8IZQ1 intact:EBI-1047414|uniprotkb:O60875|uniprotkb:Q5JVR2|uniprotkb:Q68DI4|uniprotkb:Q9H2B8|uniprotkb:Q9HCZ7|ensembl:ENSP00000343313|ensembl:ENSP00000358072 intact:EBI-1569256|uniprotkb:Q4W5K5|uniprotkb:Q6P0Q5|uniprotkb:Q8N1T2|uniprotkb:Q8NAV6|uniprotkb:Q96BS7|uniprotkb:Q96D33|uniprotkb:Q96N85|uniprotkb:Q9Y2J7|ensembl:ENSP00000295888 psi-mi:atg5_human(display_long)|uniprotkb:APG5-like(gene name synonym)|uniprotkb:Apoptosis-specific protein(gene name synonym)|uniprotkb:ATG5(gene name)|psi-mi:ATG5(display_short)|uniprotkb:APG5L(gene name synonym)|uniprotkb:ASP(gene name synonym) psi-mi:wdfy3_human(display_long)|uniprotkb:Autophagy-linked FYVE protein(gene name synonym)|uniprotkb:WDFY3(gene name)|psi-mi:WDFY3(display_short)|uniprotkb:KIAA0993(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-2936271|imex:IM-20521-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273035.1|refseq:NP_001273036.1|refseq:NP_001273037.1|refseq:NP_001273040.1|refseq:NP_004840.1|dip:DIP-29758N|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009620"(response to fungus)|go:"GO:0016020"(membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0035973"(aggrephagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0048840"(otolith development)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060047"(heart contraction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR007239(Autophagy protein 5)|interpro:IPR042526|interpro:IPR042527|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:4TQ1|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8934903|reactome:R-HSA-936440|ensembl:ENSG00000057663(gene)|ensembl:ENST00000343245(transcript)|ensembl:ENST00000369076(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002718"(regulation of cytokine production involved in immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006501"(C-terminal protein lipidation) refseq:NP_055806.2|refseq:XP_011530065.1|refseq:XP_011530067.1|ensembl:ENSG00000163625(gene)|ensembl:ENST00000295888(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR036322|interpro:IPR036372|mint:Q8IZQ1|rcsb pdb:3WIM|rcsb pdb:6W9N - - - figure legend:Fig S5A.|caution:"The Htt sequence is stated to be \"exon1\", but the exact amino acid numbers are not given."|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2010/10/13 2014/10/16 rogid:YqK4btJDQmY/dGxrmYxQmL+iAzc9606 rogid:yVIfhD/TU9JhrQR8WCChT4Jpi8c9606 intact-crc:9EF9B8F2F6534EE5|rigid:+AJyhmi7Qcoqyr48S/htvPACTxI false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q9H1Y0 uniprotkb:Q8IZQ1 intact:EBI-1047414|uniprotkb:O60875|uniprotkb:Q5JVR2|uniprotkb:Q68DI4|uniprotkb:Q9H2B8|uniprotkb:Q9HCZ7|ensembl:ENSP00000343313|ensembl:ENSP00000358072 intact:EBI-1569256|uniprotkb:Q4W5K5|uniprotkb:Q6P0Q5|uniprotkb:Q8N1T2|uniprotkb:Q8NAV6|uniprotkb:Q96BS7|uniprotkb:Q96D33|uniprotkb:Q96N85|uniprotkb:Q9Y2J7|ensembl:ENSP00000295888 psi-mi:atg5_human(display_long)|uniprotkb:APG5-like(gene name synonym)|uniprotkb:Apoptosis-specific protein(gene name synonym)|uniprotkb:ATG5(gene name)|psi-mi:ATG5(display_short)|uniprotkb:APG5L(gene name synonym)|uniprotkb:ASP(gene name synonym) psi-mi:wdfy3_human(display_long)|uniprotkb:Autophagy-linked FYVE protein(gene name synonym)|uniprotkb:WDFY3(gene name)|psi-mi:WDFY3(display_short)|uniprotkb:KIAA0993(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-2938176|imex:IM-20521-22 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273035.1|refseq:NP_001273036.1|refseq:NP_001273037.1|refseq:NP_001273040.1|refseq:NP_004840.1|dip:DIP-29758N|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009620"(response to fungus)|go:"GO:0016020"(membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0035973"(aggrephagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0048840"(otolith development)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060047"(heart contraction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR007239(Autophagy protein 5)|interpro:IPR042526|interpro:IPR042527|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:4TQ1|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8934903|reactome:R-HSA-936440|ensembl:ENSG00000057663(gene)|ensembl:ENST00000343245(transcript)|ensembl:ENST00000369076(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002718"(regulation of cytokine production involved in immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006501"(C-terminal protein lipidation) refseq:NP_055806.2|refseq:XP_011530065.1|refseq:XP_011530067.1|ensembl:ENSG00000163625(gene)|ensembl:ENST00000295888(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR036322|interpro:IPR036372|mint:Q8IZQ1|rcsb pdb:3WIM|rcsb pdb:6W9N - - - figure legend:Fig 4A panels 2, 4 and 6.|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2010/10/13 2014/10/16 rogid:YqK4btJDQmY/dGxrmYxQmL+iAzc9606 rogid:yVIfhD/TU9JhrQR8WCChT4Jpi8c9606 intact-crc:9195DCB78ECE7C6C|rigid:82ryasy2E7Y2VhXu400syk+WlLQ false - sufficient binding region:2981-3526(IPR011046)|fluorophore:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P42858 uniprotkb:Q8IZQ1 intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184 intact:EBI-1569256|uniprotkb:Q4W5K5|uniprotkb:Q6P0Q5|uniprotkb:Q8N1T2|uniprotkb:Q8NAV6|uniprotkb:Q96BS7|uniprotkb:Q96D33|uniprotkb:Q96N85|uniprotkb:Q9Y2J7|ensembl:ENSP00000295888 psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym) psi-mi:wdfy3_human(display_long)|uniprotkb:Autophagy-linked FYVE protein(gene name synonym)|uniprotkb:WDFY3(gene name)|psi-mi:WDFY3(display_short)|uniprotkb:KIAA0993(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Filimonenko et al. (2010) pubmed:20417604|imex:IM-20521 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-2936290|imex:IM-20521-20 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N refseq:NP_055806.2|refseq:XP_011530065.1|refseq:XP_011530067.1|ensembl:ENSG00000163625(gene)|ensembl:ENST00000295888(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016605"(PML body)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035973"(aggrephagy)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0097635"(extrinsic component of autophagosome membrane)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR023362|interpro:IPR036322|interpro:IPR036372|mint:Q8IZQ1|rcsb pdb:3WIM|rcsb pdb:6W9N go:"GO:0016604"(nuclear body) - - figure legend:Fig S6A.|caution:"The Htt sequence is stated to be \"exon1\", but the exact amino acid numbers are not given."|comment:"Both the N- and C-terminal fragments of Alfy interact with the polyQ protein:The N-terminal fragment completely colocalized with the Htt aggregate, while the C-terminal fragment was only found to decorate the outside of the inclusion."|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2010/10/13 2014/10/16 rogid:KyttHE2o2fORsw6iTh94LB7QShA9606 rogid:yVIfhD/TU9JhrQR8WCChT4Jpi8c9606 intact-crc:4296E1D8219DEC1B|rigid:oRbN0FizZPRo7b7BHtWvEzcUUtM false cyan fluorescent protein tag:c-c|sufficient binding region:1-170..170 sufficient binding region:1-1271|tag:?-?|sufficient binding region:2543-3526 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence)