#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q61037	uniprotkb:Q9EP53	intact:EBI-7924402|uniprotkb:Q61007|uniprotkb:Q61008|uniprotkb:P97724|uniprotkb:P97727|uniprotkb:P97725|intact:MINT-5068541|uniprotkb:Q9WUF6|uniprotkb:P97723	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	psi-mi:tsc2_mouse(display_long)|uniprotkb:Tuberous sclerosis 2 protein homolog(gene name synonym)|uniprotkb:Tsc2(gene name)|psi-mi:Tsc2(display_short)	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Miyazaki et al. (2010)	pubmed:20412061|mint:MINT-7712206|doi:10.1111/j.1742-4658.2010.07635|mint:fj-10-0034	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7924397|mint:MINT-7712211	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR018515|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024584|mint:Q61037|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005901"(caveola)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046323"(glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|reactome:R-MMU-1632852|reactome:R-MMU-165181|reactome:R-MMU-198323|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030030"(cell projection organization)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030425"(dendrite)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035176"(social behavior)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043276"(anoikis)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0030426"(growth cone)|interpro:IPR027107|interpro:IPR035974|mint:MINT-7712214(identity)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852|mint:MINT-7712213(identity)	-	function:Implicated as a tumor suppressor. May have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking. Specifically stimulates the intrinsic GTPase activity of the ras-related protein RAP1A and RAB5. Suggesting a possible mechanism for its role in regulating cellular growth|comment:mint	-	figure legend:f1b|comment:mint|partial coverage:partial coverage	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2010/03/01	2014/10/16	rogid:Sw17BM+O0FRiPsuF0+h8V/MedTM10090	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	intact-crc:0717F416027E2645|rigid:xirbvFlTZg7g6IADWa78OtnNEM4	false	phosphorylated residue:1462-1462(MINT-7712233)|phosphorylated residue:939-939(MINT-7712229)	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61037	uniprotkb:Q9EP53	intact:EBI-7924402|uniprotkb:Q61007|uniprotkb:Q61008|uniprotkb:P97724|uniprotkb:P97727|uniprotkb:P97725|intact:MINT-5068541|uniprotkb:Q9WUF6|uniprotkb:P97723	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	psi-mi:tsc2_mouse(display_long)|uniprotkb:Tuberous sclerosis 2 protein homolog(gene name synonym)|uniprotkb:Tsc2(gene name)|psi-mi:Tsc2(display_short)	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Miyazaki et al. (2010)	pubmed:20412061|mint:MINT-7712206|doi:10.1111/j.1742-4658.2010.07635|mint:fj-10-0034	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7924526|mint:MINT-7712236	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR018515|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024584|mint:Q61037|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005901"(caveola)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046323"(glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|reactome:R-MMU-1632852|reactome:R-MMU-165181|reactome:R-MMU-198323|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030030"(cell projection organization)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030425"(dendrite)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035176"(social behavior)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043276"(anoikis)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0030426"(growth cone)|interpro:IPR027107|interpro:IPR035974|mint:MINT-7712238(identity)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852|mint:MINT-7712244(identity)	-	function:Implicated as a tumor suppressor. May have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking. Specifically stimulates the intrinsic GTPase activity of the ras-related protein RAP1A and RAB5. Suggesting a possible mechanism for its role in regulating cellular growth|comment:mint	-	comment:mint|figure legend:f1b; f1c|partial coverage:partial coverage	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2010/03/01	2014/10/16	rogid:Sw17BM+O0FRiPsuF0+h8V/MedTM10090	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	intact-crc:77122193CC57AD6B|rigid:xirbvFlTZg7g6IADWa78OtnNEM4	false	phosphorylated residue:939-939(MINT-7712241)|phosphorylated residue:1462-1462(MINT-7712239)	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61037	uniprotkb:Q9EP53	intact:EBI-7924402|uniprotkb:Q61007|uniprotkb:Q61008|uniprotkb:P97724|uniprotkb:P97727|uniprotkb:P97725|intact:MINT-5068541|uniprotkb:Q9WUF6|uniprotkb:P97723	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	psi-mi:tsc2_mouse(display_long)|uniprotkb:Tuberous sclerosis 2 protein homolog(gene name synonym)|uniprotkb:Tsc2(gene name)|psi-mi:Tsc2(display_short)	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Miyazaki et al. (2010)	pubmed:20412061|mint:MINT-7712206|doi:10.1111/j.1742-4658.2010.07635|mint:fj-10-0034	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7924574|mint:MINT-7712323	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR018515|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024584|mint:Q61037|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005901"(caveola)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046323"(glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|reactome:R-MMU-1632852|reactome:R-MMU-165181|reactome:R-MMU-198323|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030030"(cell projection organization)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030425"(dendrite)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035176"(social behavior)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043276"(anoikis)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0030426"(growth cone)|interpro:IPR027107|interpro:IPR035974|mint:MINT-7712328(identity)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852|mint:MINT-7712326(identity)	go:"GO:0005829"(cytosol)	function:Implicated as a tumor suppressor. May have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking. Specifically stimulates the intrinsic GTPase activity of the ras-related protein RAP1A and RAB5. Suggesting a possible mechanism for its role in regulating cellular growth|comment:mint	-	figure legend:f2f|comment:mint|partial coverage:partial coverage	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2010/03/01	2014/10/16	rogid:Sw17BM+O0FRiPsuF0+h8V/MedTM10090	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	intact-crc:AA6AD399B4254CAA|rigid:xirbvFlTZg7g6IADWa78OtnNEM4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61037	uniprotkb:Q9EP53	intact:EBI-7924402|uniprotkb:Q61007|uniprotkb:Q61008|uniprotkb:P97724|uniprotkb:P97727|uniprotkb:P97725|intact:MINT-5068541|uniprotkb:Q9WUF6|uniprotkb:P97723	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	psi-mi:tsc2_mouse(display_long)|uniprotkb:Tuberous sclerosis 2 protein homolog(gene name synonym)|uniprotkb:Tsc2(gene name)|psi-mi:Tsc2(display_short)	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Miyazaki et al. (2010)	pubmed:20412061|mint:MINT-7712206|doi:10.1111/j.1742-4658.2010.07635|mint:fj-10-0034	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7924563|mint:MINT-7712313	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR018515|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024584|mint:Q61037|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005901"(caveola)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046323"(glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|reactome:R-MMU-1632852|reactome:R-MMU-165181|reactome:R-MMU-198323|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030030"(cell projection organization)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030425"(dendrite)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035176"(social behavior)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043276"(anoikis)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0030426"(growth cone)|interpro:IPR027107|interpro:IPR035974|mint:MINT-7712315(identity)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852|mint:MINT-7712316(identity)	go:"GO:0005829"(cytosol)	function:Implicated as a tumor suppressor. May have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking. Specifically stimulates the intrinsic GTPase activity of the ras-related protein RAP1A and RAB5. Suggesting a possible mechanism for its role in regulating cellular growth|comment:mint	-	figure legend:f2f|comment:mint|partial coverage:partial coverage	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2010/03/01	2014/10/16	rogid:Sw17BM+O0FRiPsuF0+h8V/MedTM10090	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	intact-crc:AC4E7BBB3C036804|rigid:xirbvFlTZg7g6IADWa78OtnNEM4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8BSK8	uniprotkb:Q9EP53	intact:EBI-646423|uniprotkb:Q5SWG1|uniprotkb:Q8CHX0|ensembl:ENSMUSP00000119715	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	psi-mi:ks6b1_mouse(display_long)|uniprotkb:Ribosomal protein S6 kinase I(gene name synonym)|uniprotkb:p70 ribosomal S6 kinase alpha(gene name synonym)|uniprotkb:70 kDa ribosomal protein S6 kinase 1(gene name synonym)|uniprotkb:Rps6kb1(gene name)|psi-mi:Rps6kb1(display_short)	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Miyazaki et al. (2010)	pubmed:20412061|mint:MINT-7712206|doi:10.1111/j.1742-4658.2010.07635|mint:fj-10-0034	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7924655|mint:MINT-7712399	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107806.1|ensembl:ENSMUSG00000020516(gene)|ensembl:ENSMUST00000154617(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001662"(behavioral fear response)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007281"(germ cell development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007616"(long-term memory)|go:"GO:0009408"(response to heat)|go:"GO:0009611"(response to wounding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009749"(response to glucose)|go:"GO:0009986"(cell surface)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0033762"(response to glucagon)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043201"(response to leucine)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016238(Ribosomal protein S6 kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|reactome:R-MMU-166208|mint:MINT-7712404(identity)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852|mint:MINT-7712402(identity)	go:"GO:0005829"(cytosol)	-	-	figure legend:f5b|comment:homomint|comment:mint|partial coverage:partial coverage	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2010/03/01	2014/10/16	rogid:uJPo7NVO75oHLm1/ZRG3W8uF//s10090	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	intact-crc:CF89140E43B18FD2|rigid:BuBxCvcddKOzz6dbxhXpotmZpVw	false	-	myc tag:?-?(MINT-7712414)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8BSK8	uniprotkb:Q61037	intact:EBI-646423|uniprotkb:Q5SWG1|uniprotkb:Q8CHX0|ensembl:ENSMUSP00000119715	intact:EBI-7924402|uniprotkb:Q61007|uniprotkb:Q61008|uniprotkb:P97724|uniprotkb:P97727|uniprotkb:P97725|intact:MINT-5068541|uniprotkb:Q9WUF6|uniprotkb:P97723	psi-mi:ks6b1_mouse(display_long)|uniprotkb:Ribosomal protein S6 kinase I(gene name synonym)|uniprotkb:p70 ribosomal S6 kinase alpha(gene name synonym)|uniprotkb:70 kDa ribosomal protein S6 kinase 1(gene name synonym)|uniprotkb:Rps6kb1(gene name)|psi-mi:Rps6kb1(display_short)	psi-mi:tsc2_mouse(display_long)|uniprotkb:Tuberous sclerosis 2 protein homolog(gene name synonym)|uniprotkb:Tsc2(gene name)|psi-mi:Tsc2(display_short)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Miyazaki et al. (2010)	pubmed:20412061|mint:MINT-7712206|doi:10.1111/j.1742-4658.2010.07635|mint:fj-10-0034	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7924655|mint:MINT-7712399	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107806.1|ensembl:ENSMUSG00000020516(gene)|ensembl:ENSMUST00000154617(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001662"(behavioral fear response)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007281"(germ cell development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007616"(long-term memory)|go:"GO:0009408"(response to heat)|go:"GO:0009611"(response to wounding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009749"(response to glucose)|go:"GO:0009986"(cell surface)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0033762"(response to glucagon)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043201"(response to leucine)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016238(Ribosomal protein S6 kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|reactome:R-MMU-166208|mint:MINT-7712404(identity)	interpro:IPR018515|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024584|mint:Q61037|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005901"(caveola)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046323"(glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|reactome:R-MMU-1632852|reactome:R-MMU-165181|reactome:R-MMU-198323|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030030"(cell projection organization)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030425"(dendrite)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035176"(social behavior)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043276"(anoikis)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0030426"(growth cone)|interpro:IPR027107|interpro:IPR035974|mint:MINT-7712406(identity)	go:"GO:0005829"(cytosol)	-	function:Implicated as a tumor suppressor. May have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking. Specifically stimulates the intrinsic GTPase activity of the ras-related protein RAP1A and RAB5. Suggesting a possible mechanism for its role in regulating cellular growth|comment:mint	figure legend:f5b|comment:homomint|comment:mint|partial coverage:partial coverage	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2010/03/01	2014/10/16	rogid:uJPo7NVO75oHLm1/ZRG3W8uF//s10090	rogid:Sw17BM+O0FRiPsuF0+h8V/MedTM10090	intact-crc:CF89140E43B18FD2|rigid:BuBxCvcddKOzz6dbxhXpotmZpVw	false	-	flag tag:?-?(MINT-7712409)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8BSK8	uniprotkb:Q9EP53	intact:EBI-646423|uniprotkb:Q5SWG1|uniprotkb:Q8CHX0|ensembl:ENSMUSP00000119715	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	psi-mi:ks6b1_mouse(display_long)|uniprotkb:Ribosomal protein S6 kinase I(gene name synonym)|uniprotkb:p70 ribosomal S6 kinase alpha(gene name synonym)|uniprotkb:70 kDa ribosomal protein S6 kinase 1(gene name synonym)|uniprotkb:Rps6kb1(gene name)|psi-mi:Rps6kb1(display_short)	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Miyazaki et al. (2010)	pubmed:20412061|mint:MINT-7712206|doi:10.1111/j.1742-4658.2010.07635|mint:fj-10-0034	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7924631|mint:MINT-7712277	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107806.1|ensembl:ENSMUSG00000020516(gene)|ensembl:ENSMUST00000154617(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001662"(behavioral fear response)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007281"(germ cell development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007616"(long-term memory)|go:"GO:0009408"(response to heat)|go:"GO:0009611"(response to wounding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009749"(response to glucose)|go:"GO:0009986"(cell surface)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0033762"(response to glucagon)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043201"(response to leucine)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016238(Ribosomal protein S6 kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|reactome:R-MMU-166208|mint:MINT-7712334(identity)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852|mint:MINT-7712279(identity)	go:"GO:0005829"(cytosol)	-	-	comment:homomint|comment:mint|figure legend:f2a f3b|partial coverage:partial coverage	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2010/03/01	2014/10/16	rogid:uJPo7NVO75oHLm1/ZRG3W8uF//s10090	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	intact-crc:A3F3F8A4B92AEFB3|rigid:BuBxCvcddKOzz6dbxhXpotmZpVw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8BSK8	uniprotkb:Q61037	intact:EBI-646423|uniprotkb:Q5SWG1|uniprotkb:Q8CHX0|ensembl:ENSMUSP00000119715	intact:EBI-7924402|uniprotkb:Q61007|uniprotkb:Q61008|uniprotkb:P97724|uniprotkb:P97727|uniprotkb:P97725|intact:MINT-5068541|uniprotkb:Q9WUF6|uniprotkb:P97723	psi-mi:ks6b1_mouse(display_long)|uniprotkb:Ribosomal protein S6 kinase I(gene name synonym)|uniprotkb:p70 ribosomal S6 kinase alpha(gene name synonym)|uniprotkb:70 kDa ribosomal protein S6 kinase 1(gene name synonym)|uniprotkb:Rps6kb1(gene name)|psi-mi:Rps6kb1(display_short)	psi-mi:tsc2_mouse(display_long)|uniprotkb:Tuberous sclerosis 2 protein homolog(gene name synonym)|uniprotkb:Tsc2(gene name)|psi-mi:Tsc2(display_short)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Miyazaki et al. (2010)	pubmed:20412061|mint:MINT-7712206|doi:10.1111/j.1742-4658.2010.07635|mint:fj-10-0034	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7924631|mint:MINT-7712277	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107806.1|ensembl:ENSMUSG00000020516(gene)|ensembl:ENSMUST00000154617(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001662"(behavioral fear response)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007281"(germ cell development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007616"(long-term memory)|go:"GO:0009408"(response to heat)|go:"GO:0009611"(response to wounding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009749"(response to glucose)|go:"GO:0009986"(cell surface)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0033762"(response to glucagon)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043201"(response to leucine)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016238(Ribosomal protein S6 kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|reactome:R-MMU-166208|mint:MINT-7712334(identity)	interpro:IPR018515|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024584|mint:Q61037|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005901"(caveola)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046323"(glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|reactome:R-MMU-1632852|reactome:R-MMU-165181|reactome:R-MMU-198323|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030030"(cell projection organization)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030425"(dendrite)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035176"(social behavior)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043276"(anoikis)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0030426"(growth cone)|interpro:IPR027107|interpro:IPR035974|mint:MINT-7712343(identity)	go:"GO:0005829"(cytosol)	-	function:Implicated as a tumor suppressor. May have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking. Specifically stimulates the intrinsic GTPase activity of the ras-related protein RAP1A and RAB5. Suggesting a possible mechanism for its role in regulating cellular growth|comment:mint	comment:homomint|comment:mint|figure legend:f2a f3b|partial coverage:partial coverage	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2010/03/01	2014/10/16	rogid:uJPo7NVO75oHLm1/ZRG3W8uF//s10090	rogid:Sw17BM+O0FRiPsuF0+h8V/MedTM10090	intact-crc:A3F3F8A4B92AEFB3|rigid:BuBxCvcddKOzz6dbxhXpotmZpVw	false	-	phosphorylated residue:1462-1462(MINT-7712345)|phosphorylated residue:939-939(MINT-7712349)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61037	uniprotkb:Q9EP53	intact:EBI-7924402|uniprotkb:Q61007|uniprotkb:Q61008|uniprotkb:P97724|uniprotkb:P97727|uniprotkb:P97725|intact:MINT-5068541|uniprotkb:Q9WUF6|uniprotkb:P97723	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	psi-mi:tsc2_mouse(display_long)|uniprotkb:Tuberous sclerosis 2 protein homolog(gene name synonym)|uniprotkb:Tsc2(gene name)|psi-mi:Tsc2(display_short)	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Miyazaki et al. (2010)	pubmed:20412061|mint:MINT-7712206|doi:10.1111/j.1742-4658.2010.07635|mint:fj-10-0034	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7924811|mint:MINT-7712483	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR018515|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024584|mint:Q61037|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005901"(caveola)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046323"(glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|reactome:R-MMU-1632852|reactome:R-MMU-165181|reactome:R-MMU-198323|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030030"(cell projection organization)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030425"(dendrite)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035176"(social behavior)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043276"(anoikis)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0030426"(growth cone)|interpro:IPR027107|interpro:IPR035974|mint:MINT-7712486(identity)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852|mint:MINT-7712492(identity)	go:"GO:0005886"(plasma membrane)	function:Implicated as a tumor suppressor. May have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking. Specifically stimulates the intrinsic GTPase activity of the ras-related protein RAP1A and RAB5. Suggesting a possible mechanism for its role in regulating cellular growth|comment:mint	-	figure legend:f5b|comment:mint|partial coverage:partial coverage	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2010/03/01	2014/10/16	rogid:Sw17BM+O0FRiPsuF0+h8V/MedTM10090	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	intact-crc:260CF89EB236F986|rigid:xirbvFlTZg7g6IADWa78OtnNEM4	false	flag tag:?-?(MINT-7712487)	myc tag:?-?(MINT-7712493)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q921J2	uniprotkb:Q9EP53	intact:EBI-7924728|intact:MINT-4611176|ensembl:ENSMUSP00000030787	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	psi-mi:rheb_mouse(display_long)|uniprotkb:Rheb(gene name)|psi-mi:Rheb(display_short)|uniprotkb:Ras homolog enriched in brain(gene name synonym)	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Miyazaki et al. (2010)	pubmed:20412061|mint:MINT-7712206|doi:10.1111/j.1742-4658.2010.07635|mint:fj-10-0034	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7924753|mint:MINT-7712451	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_444305.2|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:2000074"(regulation of type B pancreatic cell development)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR037586|mint:Q921J2|rcsb pdb:4O25|rcsb pdb:4O2L|rcsb pdb:4O2R|reactome:R-MMU-1632852|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8943724|reactome:R-MMU-9639288|ensembl:ENSMUSG00000028945(gene)|ensembl:ENSMUST00000030787(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|mint:MINT-7712459(identity)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852|mint:MINT-7712463(identity)	go:"GO:0005886"(plasma membrane)	function:Not known; binds GTP and exhibits intrinsic GTPase activity|comment:mint	-	comment:homomint|comment:mint|figure legend:f2a|partial coverage:partial coverage	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2010/03/01	2014/10/16	rogid:hWQL1uMB4w4vwGD6IZBHfOx9UaI10090	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	intact-crc:42D7BA334514F7B7|rigid:Fq4F+fiD5PJkWR52VQcF25e1xRU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q921J2	uniprotkb:Q61037	intact:EBI-7924728|intact:MINT-4611176|ensembl:ENSMUSP00000030787	intact:EBI-7924402|uniprotkb:Q61007|uniprotkb:Q61008|uniprotkb:P97724|uniprotkb:P97727|uniprotkb:P97725|intact:MINT-5068541|uniprotkb:Q9WUF6|uniprotkb:P97723	psi-mi:rheb_mouse(display_long)|uniprotkb:Rheb(gene name)|psi-mi:Rheb(display_short)|uniprotkb:Ras homolog enriched in brain(gene name synonym)	psi-mi:tsc2_mouse(display_long)|uniprotkb:Tuberous sclerosis 2 protein homolog(gene name synonym)|uniprotkb:Tsc2(gene name)|psi-mi:Tsc2(display_short)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Miyazaki et al. (2010)	pubmed:20412061|mint:MINT-7712206|doi:10.1111/j.1742-4658.2010.07635|mint:fj-10-0034	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7924753|mint:MINT-7712451	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_444305.2|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:2000074"(regulation of type B pancreatic cell development)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR037586|mint:Q921J2|rcsb pdb:4O25|rcsb pdb:4O2L|rcsb pdb:4O2R|reactome:R-MMU-1632852|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8943724|reactome:R-MMU-9639288|ensembl:ENSMUSG00000028945(gene)|ensembl:ENSMUST00000030787(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|mint:MINT-7712459(identity)	interpro:IPR018515|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024584|mint:Q61037|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005901"(caveola)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046323"(glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|reactome:R-MMU-1632852|reactome:R-MMU-165181|reactome:R-MMU-198323|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030030"(cell projection organization)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030425"(dendrite)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035176"(social behavior)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043276"(anoikis)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0030426"(growth cone)|interpro:IPR027107|interpro:IPR035974|mint:MINT-7712453(identity)	go:"GO:0005886"(plasma membrane)	function:Not known; binds GTP and exhibits intrinsic GTPase activity|comment:mint	function:Implicated as a tumor suppressor. May have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking. Specifically stimulates the intrinsic GTPase activity of the ras-related protein RAP1A and RAB5. Suggesting a possible mechanism for its role in regulating cellular growth|comment:mint	comment:homomint|comment:mint|figure legend:f2a|partial coverage:partial coverage	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2010/03/01	2014/10/16	rogid:hWQL1uMB4w4vwGD6IZBHfOx9UaI10090	rogid:Sw17BM+O0FRiPsuF0+h8V/MedTM10090	intact-crc:42D7BA334514F7B7|rigid:Fq4F+fiD5PJkWR52VQcF25e1xRU	false	-	phosphorylated residue:1462-1462(MINT-7712456)|phosphorylated residue:939-939(MINT-7712454)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9CQV8	uniprotkb:Q61037	intact:EBI-771608|uniprotkb:O70455|uniprotkb:Q3TY33|uniprotkb:Q3UAN6|ensembl:ENSMUSP00000018470	intact:EBI-7924402|uniprotkb:Q61007|uniprotkb:Q61008|uniprotkb:P97724|uniprotkb:P97727|uniprotkb:P97725|intact:MINT-5068541|uniprotkb:Q9WUF6|uniprotkb:P97723	psi-mi:1433b_mouse(display_long)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:Ywhab(gene name)|psi-mi:Ywhab(display_short)	psi-mi:tsc2_mouse(display_long)|uniprotkb:Tuberous sclerosis 2 protein homolog(gene name synonym)|uniprotkb:Tsc2(gene name)|psi-mi:Tsc2(display_short)	psi-mi:"MI:0096"(pull down)	Miyazaki et al. (2010)	pubmed:20412061|mint:MINT-7712206|doi:10.1111/j.1742-4658.2010.07635|mint:fj-10-0034	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7924868|mint:MINT-7712377	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061223.2|refseq:XP_006499972.1|reactome:R-MMU-111447|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-170968|reactome:R-MMU-2028269|reactome:R-MMU-392517|reactome:R-MMU-450385|reactome:R-MMU-450513|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5675221|reactome:R-MMU-75035|reactome:R-MMU-9614399|ensembl:ENSMUSG00000018326(gene)|ensembl:ENSMUST00000018470(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|rcsb pdb:4GNT|rcsb pdb:5F74|rcsb pdb:5WFU|rcsb pdb:5WFX|mint:MINT-7712379(identity)	interpro:IPR018515|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024584|mint:Q61037|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005901"(caveola)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046323"(glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|reactome:R-MMU-1632852|reactome:R-MMU-165181|reactome:R-MMU-198323|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030030"(cell projection organization)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030425"(dendrite)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035176"(social behavior)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043276"(anoikis)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0030426"(growth cone)|interpro:IPR027107|interpro:IPR035974|mint:MINT-7712380(identity)	-	-	function:Implicated as a tumor suppressor. May have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking. Specifically stimulates the intrinsic GTPase activity of the ras-related protein RAP1A and RAB5. Suggesting a possible mechanism for its role in regulating cellular growth|comment:mint	figure legend:f5a|comment:homomint|comment:domino|comment:mint|partial coverage:partial coverage	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/03/01	2014/10/16	rogid:g94luGOxfq+Jbi0ztZ7gbAkp+2A10090	rogid:Sw17BM+O0FRiPsuF0+h8V/MedTM10090	intact-crc:3E4AED4590B73E3E|rigid:ekhY/DFdruEqnDbW1aDiNFT81zE	false	glutathione s tranferase tag:?-?(MINT-7712391)	flag tag:?-?(MINT-7712387)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9CQV8	uniprotkb:Q9EP53	intact:EBI-771608|uniprotkb:O70455|uniprotkb:Q3TY33|uniprotkb:Q3UAN6|ensembl:ENSMUSP00000018470	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	psi-mi:1433b_mouse(display_long)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:Ywhab(gene name)|psi-mi:Ywhab(display_short)	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:"MI:0096"(pull down)	Miyazaki et al. (2010)	pubmed:20412061|mint:MINT-7712206|doi:10.1111/j.1742-4658.2010.07635|mint:fj-10-0034	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7924868|mint:MINT-7712377	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061223.2|refseq:XP_006499972.1|reactome:R-MMU-111447|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-170968|reactome:R-MMU-2028269|reactome:R-MMU-392517|reactome:R-MMU-450385|reactome:R-MMU-450513|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5675221|reactome:R-MMU-75035|reactome:R-MMU-9614399|ensembl:ENSMUSG00000018326(gene)|ensembl:ENSMUST00000018470(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|rcsb pdb:4GNT|rcsb pdb:5F74|rcsb pdb:5WFU|rcsb pdb:5WFX|mint:MINT-7712379(identity)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852|mint:MINT-7712381(identity)	-	-	-	figure legend:f5a|comment:homomint|comment:domino|comment:mint|partial coverage:partial coverage	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/03/01	2014/10/16	rogid:g94luGOxfq+Jbi0ztZ7gbAkp+2A10090	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	intact-crc:3E4AED4590B73E3E|rigid:ekhY/DFdruEqnDbW1aDiNFT81zE	false	glutathione s tranferase tag:?-?(MINT-7712391)	mutation decreasing interaction:939-939(MINT-7712395)|myc tag:?-?(MINT-7712383)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q92574	uniprotkb:P49815	intact:EBI-1047085|uniprotkb:Q5VVN5|intact:EBI-1386638|intact:EBI-28978933|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENSP00000495158|ensembl:ENSP00000496263|uniprotkb:B7Z897	intact:EBI-396587|uniprotkb:O75275|uniprotkb:Q8TAZ1|uniprotkb:A7E2E2|uniprotkb:B4DIQ7|uniprotkb:B4DRN2|uniprotkb:Q4LE71|uniprotkb:C9J378|ensembl:ENSP00000219476|uniprotkb:B4DIL8|uniprotkb:B7Z2B8	psi-mi:tsc1_human(display_long)|uniprotkb:TSC1(gene name)|psi-mi:TSC1(display_short)|uniprotkb:KIAA0243(gene name synonym)|uniprotkb:Tuberous sclerosis 1 protein(gene name synonym)|uniprotkb:TSC(gene name synonym)	psi-mi:tsc2_human(display_long)|uniprotkb:TSC2(gene name)|psi-mi:TSC2(display_short)|uniprotkb:Tuberous sclerosis 2 protein(gene name synonym)|uniprotkb:TSC4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Miyazaki et al. (2010)	pubmed:20412061|mint:MINT-7712206|doi:10.1111/j.1742-4658.2010.07635|mint:fj-10-0034	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7924963|mint:MINT-7712436	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000359.1|refseq:NP_001155898.1|refseq:NP_001155899.1|refseq:XP_011517281.1|ensembl:ENSP00000298552|ensembl:ENSP00000394524|ensembl:ENST00000545250|ensembl:ENSP00000444017|ensembl:ENST00000643072|ensembl:ENSP00000496691|ensembl:ENSP00000495158|ensembl:ENSP00000496263|ensembl:ENSG00000165699(gene)|ensembl:ENST00000298552(transcript)|ensembl:ENST00000440111(transcript)|ensembl:ENST00000643875(transcript)|ensembl:ENST00000646625(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|mint:Q92574|rcsb pdb:4Z6Y|rcsb pdb:5EJC|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8854214|refseq:XP_005272268.1|refseq:XP_006717334.1|refseq:XP_016870585.1|refseq:XP_016870586.1|mint:MINT-7712439(identity)	refseq:NP_000539.2|refseq:NP_001070651.1|refseq:NP_001107854.1|ensembl:ENSG00000103197(gene)|ensembl:ENST00000219476(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006897"(endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0008104"(protein localization)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|refseq:NP_001305756.1|refseq:NP_001305758.1|refseq:NP_001305760.1|refseq:NP_001305761.1|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043276"(anoikis)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:1901525"(negative regulation of mitophagy)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR003913(Tuberin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018515|interpro:IPR024584|interpro:IPR027107|interpro:IPR035974|mint:P49815|rcsb pdb:7DL2|reactome:R-HSA-1632852|reactome:R-HSA-165181|reactome:R-HSA-198323|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-8854214|refseq:XP_005255586.2|refseq:XP_016879105.1|mint:MINT-7712438(identity)	-	-	-	comment:homomint|comment:mint|figure legend:fs2|partial coverage:partial coverage	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/03/01	2014/10/16	rogid:Frpc4GasNNqHfgr9tr7TUPfKZx09606	rogid:II0K3oybyrXfM4GEYMwV2ZyoWwE9606	intact-crc:21DC5FE9AA1AEA44|rigid:FrBXCSnimJENxHO37xNuWWmtagU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9EP53	uniprotkb:Q9CQV8	intact:EBI-1202690|uniprotkb:A2AHW1|uniprotkb:Q3UHF2|uniprotkb:Q7TS92|uniprotkb:Q80U55|uniprotkb:Q924U7|ensembl:ENSMUSP00000109500	intact:EBI-771608|uniprotkb:O70455|uniprotkb:Q3TY33|uniprotkb:Q3UAN6|ensembl:ENSMUSP00000018470	psi-mi:tsc1_mouse(display_long)|uniprotkb:Tsc1(gene name)|psi-mi:Tsc1(display_short)|uniprotkb:Tuberous sclerosis 1 protein homolog(gene name synonym)|uniprotkb:Kiaa0243(gene name synonym)	psi-mi:1433b_mouse(display_long)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:Ywhab(gene name)|psi-mi:Ywhab(display_short)	psi-mi:"MI:0096"(pull down)	Miyazaki et al. (2010)	pubmed:20412061|mint:MINT-7712206|doi:10.1111/j.1742-4658.2010.07635|mint:fj-10-0034	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7925010|mint:MINT-8009927	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011237446.1|refseq:NP_001276504.1|refseq:NP_001276505.1|refseq:NP_075025.2|reactome:R-MMU-165181|reactome:R-MMU-380972|reactome:R-MMU-5628897|reactome:R-MMU-8854214|go:"GO:0006417"(regulation of translation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030426"(growth cone)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033596"(TSC1-TSC2 complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042552"(myelination)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043379"(memory T cell differentiation)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045792"(negative regulation of cell size)|ensembl:ENSMUSG00000026812(gene)|ensembl:ENSMUST00000113869(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005938"(cell cortex)|go:"GO:0006407"(rRNA export from nucleus)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046323"(glucose import)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0101031"(chaperone complex)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|interpro:IPR007483(Hamartin)|interpro:IPR016024(Armadillo-type fold)|reactome:R-MMU-1632852|mint:MINT-8009931(identity)|uniprotkb:Q9EP53(original identifier)	refseq:NP_061223.2|refseq:XP_006499972.1|reactome:R-MMU-111447|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-170968|reactome:R-MMU-2028269|reactome:R-MMU-392517|reactome:R-MMU-450385|reactome:R-MMU-450513|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5675221|reactome:R-MMU-75035|reactome:R-MMU-9614399|ensembl:ENSMUSG00000018326(gene)|ensembl:ENSMUST00000018470(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|rcsb pdb:4GNT|rcsb pdb:5F74|rcsb pdb:5WFU|rcsb pdb:5WFX|mint:MINT-8009928(identity)|uniprotkb:Q9CQV8(original identifier)	-	-	-	comment:homomint|comment:domino|comment:mint|partial coverage:partial coverage	taxid:-3(unknown)|taxid:-3(Unknown)	-	2010/03/01	2014/10/16	rogid:bHzTi+QCBf+QRwYEbNFcrY39c1w10090	rogid:g94luGOxfq+Jbi0ztZ7gbAkp+2A10090	intact-crc:AEE41B05325E437F|rigid:DGgci2PfoBhweh3PGiotaiyq3HA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)