#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P31483 uniprotkb:Q4VGL6 intact:EBI-1387216|uniprotkb:Q53SS9|uniprotkb:Q96B58|ensembl:ENSP00000401371 intact:EBI-2366263|uniprotkb:Q69Z31|uniprotkb:B2RS13|ensembl:ENSMUSP00000124871 psi-mi:tia1_human(display_long)|uniprotkb:TIA1(gene name)|psi-mi:TIA1(display_short)|uniprotkb:p40-TIA-1(gene name synonym)|uniprotkb:RNA-binding protein TIA-1(gene name synonym)|uniprotkb:T-cell-restricted intracellular antigen-1(gene name synonym) psi-mi:rc3h1_mouse(display_long)|uniprotkb:Rc3h1(gene name)|psi-mi:Rc3h1(display_short)|uniprotkb:Gm551(gene name synonym)|uniprotkb:Kiaa2025(gene name synonym)|uniprotkb:RING finger and C3H zinc finger protein 1(gene name synonym)|uniprotkb:Protein Sanroque(gene name synonym)|uniprotkb:RING finger and CCCH-type zinc finger domain-containing protein 1(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Athanasopoulos et al. (2010) pubmed:20412057|imex:IM-15706|mint:MINT-7711136|mint:fj-09-1483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7921588|mint:MINT-7711163|imex:IM-15706-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071320.2|refseq:NP_071505.2|ensembl:ENSG00000116001(gene)|ensembl:ENST00000433529(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008143"("poly(A) binding")|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0097165"(nuclear stress granule)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034830|interpro:IPR034832|interpro:IPR035979|rcsb pdb:2MJN|rcsb pdb:3BS9|rcsb pdb:5ITH|rcsb pdb:5O2V|rcsb pdb:5O3J|rcsb pdb:6ELD|reactome:R-HSA-6803529|mint:P31483|mint:MINT-7711166(identity) refseq:NP_001020123.1|ensembl:ENSMUSG00000040423(gene)|ensembl:ENSMUST00000161609(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002635"(negative regulation of germinal center formation)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0033962"(P-body assembly)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0042098"(T cell proliferation)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045623"(negative regulation of T-helper cell differentiation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0061470"(T follicular helper cell differentiation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:1900151"(regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1905762"(CCR4-NOT complex binding)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|go:"GO:2000628"(regulation of miRNA metabolic process)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027370|interpro:IPR032671|interpro:IPR036855|interpro:IPR041523|rcsb pdb:4QI0|rcsb pdb:4QI2|rcsb pdb:4TXA|rcsb pdb:5F5F|rcsb pdb:5F5H|rcsb pdb:6TQA|rcsb pdb:6TQB|mint:MINT-7711165(identity) go:"GO:0010494"(cytoplasmic stress granule) - - comment:homomint|comment:mint|figure legend:f1a f4c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2010/02/22 2014/10/16 rogid:d2ecwJo5sjSY6a/By3GM3B5A6PE9606 rogid:MRRQ1OTzvG6aSUot+T7O69K1jxo10090 intact-crc:CF827DE6A05FF6D1|rigid:eidcI8n3D2FGdgaRwMUvdzJxtfc false - binding-associated region:138-377(MINT-7711188) - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P31483 uniprotkb:Q9HBD1 intact:EBI-1387216|uniprotkb:Q53SS9|uniprotkb:Q96B58|ensembl:ENSP00000401371 intact:EBI-2340719|uniprotkb:Q8N3D6|uniprotkb:Q9H5J2|uniprotkb:Q9NWN9|uniprotkb:Q9NXE1|uniprotkb:Q86ST6|uniprotkb:Q5JPD7|uniprotkb:Q9HBD2|uniprotkb:Q96F27|uniprotkb:Q4VXB1|ensembl:ENSP00000349783|ensembl:ENSP00000362774 psi-mi:tia1_human(display_long)|uniprotkb:TIA1(gene name)|psi-mi:TIA1(display_short)|uniprotkb:p40-TIA-1(gene name synonym)|uniprotkb:RNA-binding protein TIA-1(gene name synonym)|uniprotkb:T-cell-restricted intracellular antigen-1(gene name synonym) psi-mi:rc3h2_human(display_long)|uniprotkb:RC3H2(gene name)|psi-mi:RC3H2(display_short)|uniprotkb:MNAB(gene name synonym)|uniprotkb:RNF164(gene name synonym)|uniprotkb:Membrane-associated nucleic acid-binding protein(gene name synonym)|uniprotkb:RING finger protein 164(gene name synonym)|uniprotkb:RING finger and CCCH-type zinc finger domain-containing protein 2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Roquin-2(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Athanasopoulos et al. (2010) pubmed:20412057|imex:IM-15706|mint:MINT-7711136|mint:fj-09-1483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7921653|mint:MINT-7711447|imex:IM-15706-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071320.2|refseq:NP_071505.2|ensembl:ENSG00000116001(gene)|ensembl:ENST00000433529(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008143"("poly(A) binding")|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0097165"(nuclear stress granule)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034830|interpro:IPR034832|interpro:IPR035979|rcsb pdb:2MJN|rcsb pdb:3BS9|rcsb pdb:5ITH|rcsb pdb:5O2V|rcsb pdb:5O3J|rcsb pdb:6ELD|reactome:R-HSA-6803529|mint:P31483|mint:MINT-7711450(identity) refseq:NP_001094058.1|refseq:NP_061323.2|ensembl:ENSG00000056586(gene)|ensembl:ENST00000357244(transcript)|ensembl:ENST00000373670(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0000932"(P-body)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0042098"(T cell proliferation)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060173"(limb development)|go:"GO:0061470"(T follicular helper cell differentiation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|go:"GO:2000628"(regulation of miRNA metabolic process)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027370|interpro:IPR032670|interpro:IPR036855|interpro:IPR041523|rcsb pdb:4Z30|rcsb pdb:4Z31|rcsb pdb:4ZLC|rcsb pdb:4ZLD|mint:MINT-7711452(identity) go:"GO:0010494"(cytoplasmic stress granule) - - figure legend:sf2e|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2010/02/22 2014/10/16 rogid:d2ecwJo5sjSY6a/By3GM3B5A6PE9606 rogid:UThBG9DsQJ7jfnx9xkCBkBKkaT89606 intact-crc:31E6F878E4E6B239|rigid:WgQlXcN/lnTbteL6In8tFVxVP9g false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q4VGL6 uniprotkb:P55884 intact:EBI-2366263|uniprotkb:Q69Z31|uniprotkb:B2RS13|ensembl:ENSMUSP00000124871 intact:EBI-366696|uniprotkb:Q2NL77|uniprotkb:Q9UMF9|uniprotkb:A4D208|ensembl:ENSP00000354125|ensembl:ENSP00000380206 psi-mi:rc3h1_mouse(display_long)|uniprotkb:Rc3h1(gene name)|psi-mi:Rc3h1(display_short)|uniprotkb:Gm551(gene name synonym)|uniprotkb:Kiaa2025(gene name synonym)|uniprotkb:RING finger and C3H zinc finger protein 1(gene name synonym)|uniprotkb:Protein Sanroque(gene name synonym)|uniprotkb:RING finger and CCCH-type zinc finger domain-containing protein 1(gene name synonym) psi-mi:eif3b_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 9(gene name synonym)|uniprotkb:eIF-3-eta(gene name synonym)|uniprotkb:eIF3 p116(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym)|uniprotkb:Prt1 homolog(gene name synonym)|uniprotkb:EIF3B(gene name)|psi-mi:EIF3B(display_short)|uniprotkb:EIF3S9(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Athanasopoulos et al. (2010) pubmed:20412057|imex:IM-15706|mint:MINT-7711136|mint:fj-09-1483 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7921622|mint:MINT-7711176|imex:IM-15706-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001020123.1|ensembl:ENSMUSG00000040423(gene)|ensembl:ENSMUST00000161609(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002635"(negative regulation of germinal center formation)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0033962"(P-body assembly)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0042098"(T cell proliferation)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045623"(negative regulation of T-helper cell differentiation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0061470"(T follicular helper cell differentiation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:1900151"(regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1905762"(CCR4-NOT complex binding)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|go:"GO:2000628"(regulation of miRNA metabolic process)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027370|interpro:IPR032671|interpro:IPR036855|interpro:IPR041523|rcsb pdb:4QI0|rcsb pdb:4QI2|rcsb pdb:4TXA|rcsb pdb:5F5F|rcsb pdb:5F5H|rcsb pdb:6TQA|rcsb pdb:6TQB|mint:MINT-7711181(identity) refseq:NP_001032360.1|refseq:NP_003742.2|refseq:XP_011513901.1|refseq:XP_011513902.1|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|ensembl:ENSG00000106263(gene)|ensembl:ENST00000360876(transcript)|ensembl:ENST00000397011(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR011400(Translation initiation factor eIF-3b)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR013979(Eukaryotic translation initiation factor 2A, central region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR034363|interpro:IPR035979|mint:P55884|rcsb pdb:2KRB|rcsb pdb:2NLW|rcsb pdb:5K1H|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:XP_016868241.1|dip:DIP-31113N|mint:MINT-7711179(identity) go:"GO:0010494"(cytoplasmic stress granule) - - figure legend:f1a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2010/02/22 2014/10/16 rogid:MRRQ1OTzvG6aSUot+T7O69K1jxo10090 rogid:MxQFPvmuOcO/S+4NqzToozWr8K89606 intact-crc:58750E4A47D2912B|rigid:90/arNT0sXChcBQVcwlF7CcSSyk false green fluorescent protein tag:?-?(MINT-7711182) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0422"(immunostaining) uniprotkb:P31483 uniprotkb:Q9NPI6 intact:EBI-1387216|uniprotkb:Q53SS9|uniprotkb:Q96B58|ensembl:ENSP00000401371 intact:EBI-374238|ensembl:ENSP00000476386|uniprotkb:B4DHN9|uniprotkb:U3KQM8 psi-mi:tia1_human(display_long)|uniprotkb:TIA1(gene name)|psi-mi:TIA1(display_short)|uniprotkb:p40-TIA-1(gene name synonym)|uniprotkb:RNA-binding protein TIA-1(gene name synonym)|uniprotkb:T-cell-restricted intracellular antigen-1(gene name synonym) psi-mi:dcp1a_human(display_long)|uniprotkb:DCP1A(gene name)|psi-mi:DCP1A(display_short)|uniprotkb:Transcription factor SMIF(gene name synonym)|uniprotkb:Smad4-interacting transcriptional co-activator(gene name synonym)|uniprotkb:SMIF(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Athanasopoulos et al. (2010) pubmed:20412057|imex:IM-15706|mint:MINT-7711136|mint:fj-09-1483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7921638|mint:MINT-7711192|imex:IM-15706-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071320.2|refseq:NP_071505.2|ensembl:ENSG00000116001(gene)|ensembl:ENST00000433529(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008143"("poly(A) binding")|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0097165"(nuclear stress granule)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034830|interpro:IPR034832|interpro:IPR035979|rcsb pdb:2MJN|rcsb pdb:3BS9|rcsb pdb:5ITH|rcsb pdb:5O2V|rcsb pdb:5O3J|rcsb pdb:6ELD|reactome:R-HSA-6803529|mint:P31483|mint:MINT-7711195(identity) ensembl:ENSG00000272886(gene)|ensembl:ENST00000610213(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q9NPI6|rcsb pdb:2WX3|rcsb pdb:4B6H|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-975957|refseq:NP_060873.4|refseq:NP_001277133.1|refseq:NP_001277136.1|refseq:NP_001277134.1|refseq:NP_001277135.1|dip:DIP-31292N|mint:MINT-7711197(identity) - - - figure legend:f2b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2010/02/22 2018/09/18 rogid:d2ecwJo5sjSY6a/By3GM3B5A6PE9606 rogid:KIg2pPmAEIiig2SXAJNziN91oCY9606 intact-crc:9DB2593F659AE013|rigid:YG5HBa9HpFNys1syq7KlvjmVJUc false green fluorescent protein tag:?-?(MINT-7711203) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q9HBD1 uniprotkb:P31483 intact:EBI-2340719|uniprotkb:Q8N3D6|uniprotkb:Q9H5J2|uniprotkb:Q9NWN9|uniprotkb:Q9NXE1|uniprotkb:Q86ST6|uniprotkb:Q5JPD7|uniprotkb:Q9HBD2|uniprotkb:Q96F27|uniprotkb:Q4VXB1|ensembl:ENSP00000349783|ensembl:ENSP00000362774 intact:EBI-1387216|uniprotkb:Q53SS9|uniprotkb:Q96B58|ensembl:ENSP00000401371 psi-mi:rc3h2_human(display_long)|uniprotkb:RC3H2(gene name)|psi-mi:RC3H2(display_short)|uniprotkb:MNAB(gene name synonym)|uniprotkb:RNF164(gene name synonym)|uniprotkb:Membrane-associated nucleic acid-binding protein(gene name synonym)|uniprotkb:RING finger protein 164(gene name synonym)|uniprotkb:RING finger and CCCH-type zinc finger domain-containing protein 2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Roquin-2(gene name synonym) psi-mi:tia1_human(display_long)|uniprotkb:TIA1(gene name)|psi-mi:TIA1(display_short)|uniprotkb:p40-TIA-1(gene name synonym)|uniprotkb:RNA-binding protein TIA-1(gene name synonym)|uniprotkb:T-cell-restricted intracellular antigen-1(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Athanasopoulos et al. (2010) pubmed:20412057|imex:IM-15706|mint:MINT-7711136|mint:fj-09-1483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7921667|mint:MINT-7711460|imex:IM-15706-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001094058.1|refseq:NP_061323.2|ensembl:ENSG00000056586(gene)|ensembl:ENST00000357244(transcript)|ensembl:ENST00000373670(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0000932"(P-body)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0042098"(T cell proliferation)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060173"(limb development)|go:"GO:0061470"(T follicular helper cell differentiation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|go:"GO:2000628"(regulation of miRNA metabolic process)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027370|interpro:IPR032670|interpro:IPR036855|interpro:IPR041523|rcsb pdb:4Z30|rcsb pdb:4Z31|rcsb pdb:4ZLC|rcsb pdb:4ZLD|mint:MINT-7711463(identity) refseq:NP_071320.2|refseq:NP_071505.2|ensembl:ENSG00000116001(gene)|ensembl:ENST00000433529(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008143"("poly(A) binding")|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0097165"(nuclear stress granule)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034830|interpro:IPR034832|interpro:IPR035979|rcsb pdb:2MJN|rcsb pdb:3BS9|rcsb pdb:5ITH|rcsb pdb:5O2V|rcsb pdb:5O3J|rcsb pdb:6ELD|reactome:R-HSA-6803529|mint:P31483|mint:MINT-7711467(identity) go:"GO:0010494"(cytoplasmic stress granule) - - comment:homomint|comment:mint|figure legend:sf2a sf3f|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2010/02/22 2014/10/16 rogid:UThBG9DsQJ7jfnx9xkCBkBKkaT89606 rogid:d2ecwJo5sjSY6a/By3GM3B5A6PE9606 intact-crc:2BC6E57DBCE59551|rigid:WgQlXcN/lnTbteL6In8tFVxVP9g false binding-associated region:1-443(MINT-7711503) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0422"(immunostaining) uniprotkb:P31483 uniprotkb:O45962 intact:EBI-1387216|uniprotkb:Q53SS9|uniprotkb:Q96B58|ensembl:ENSP00000401371 intact:EBI-317751|uniprotkb:Q93898|uniprotkb:F5GUI8|uniprotkb:G5EDG1|ensemblmetazoa:M142.6a.1 psi-mi:tia1_human(display_long)|uniprotkb:TIA1(gene name)|psi-mi:TIA1(display_short)|uniprotkb:p40-TIA-1(gene name synonym)|uniprotkb:RNA-binding protein TIA-1(gene name synonym)|uniprotkb:T-cell-restricted intracellular antigen-1(gene name synonym) psi-mi:rle1_caeel(display_long)|uniprotkb:rle-1(gene name)|psi-mi:rle-1(display_short)|uniprotkb:RING-type E3 ubiquitin transferase rle-1(gene name synonym)|uniprotkb:M142.6(orf name) psi-mi:"MI:0416"(fluorescence microscopy) Athanasopoulos et al. (2010) pubmed:20412057|imex:IM-15706|mint:MINT-7711136|mint:fj-09-1483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7921683|mint:MINT-7711475|imex:IM-15706-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071320.2|refseq:NP_071505.2|ensembl:ENSG00000116001(gene)|ensembl:ENST00000433529(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008143"("poly(A) binding")|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0097165"(nuclear stress granule)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034830|interpro:IPR034832|interpro:IPR035979|rcsb pdb:2MJN|rcsb pdb:3BS9|rcsb pdb:5ITH|rcsb pdb:5O2V|rcsb pdb:5O3J|rcsb pdb:6ELD|reactome:R-HSA-6803529|mint:P31483|mint:MINT-7711478(identity) refseq:NP_001255093.1|refseq:NP_001255094.1|refseq:NP_001255095.1|wormbase:M142.6a|wormbase:M142.6b|wormbase:M142.6c|ensemblmetazoa:M142.6a.1(transcript)|ensemblmetazoa:WBGene00010923(gene)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009408"(response to heat)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR041523|dip:DIP-24657N|mint:MINT-7711480(identity) go:"GO:0010494"(cytoplasmic stress granule) - - figure legend:sf2b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2010/02/22 2014/10/16 rogid:d2ecwJo5sjSY6a/By3GM3B5A6PE9606 rogid:3d6G2jQFntXr4yxgoSUZnUBnGRU6239 intact-crc:286E0C791626EBFA|rigid:+oEBkfcObZYwPdWswABtNrM3kDM false - green fluorescent protein tag:?-?(MINT-7711481) - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P31483 uniprotkb:Q9VV48 intact:EBI-1387216|uniprotkb:Q53SS9|uniprotkb:Q96B58|ensembl:ENSP00000401371 intact:EBI-138710|ensemblmetazoa:FBpp0075181|ensemblmetazoa:FBpp0303600|ensemblmetazoa:FBpp0305463 psi-mi:tia1_human(display_long)|uniprotkb:TIA1(gene name)|psi-mi:TIA1(display_short)|uniprotkb:p40-TIA-1(gene name synonym)|uniprotkb:RNA-binding protein TIA-1(gene name synonym)|uniprotkb:T-cell-restricted intracellular antigen-1(gene name synonym) psi-mi:q9vv48_drome(display_long)|uniprotkb:roq(gene name)|psi-mi:roq(display_short)|uniprotkb:Dmel\CG16807(gene name synonym)|uniprotkb:"NEST:bs21b12"(gene name synonym)|uniprotkb:Roq(gene name synonym)|uniprotkb:CG16807(orf name)|uniprotkb:Dmel_CG16807(orf name) psi-mi:"MI:0416"(fluorescence microscopy) Athanasopoulos et al. (2010) pubmed:20412057|imex:IM-15706|mint:MINT-7711136|mint:fj-09-1483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7921706|mint:MINT-7711487|imex:IM-15706-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071320.2|refseq:NP_071505.2|ensembl:ENSG00000116001(gene)|ensembl:ENST00000433529(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008143"("poly(A) binding")|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0097165"(nuclear stress granule)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034830|interpro:IPR034832|interpro:IPR035979|rcsb pdb:2MJN|rcsb pdb:3BS9|rcsb pdb:5ITH|rcsb pdb:5O2V|rcsb pdb:5O3J|rcsb pdb:6ELD|reactome:R-HSA-6803529|mint:P31483|mint:MINT-7711494(identity) refseq:NP_648886.1|flybase:FBgn0036621|refseq:NP_001261940.1|refseq:NP_001261941.1|ensemblmetazoa:FBgn0036621(gene)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|ensemblmetazoa:FBtr0075423(transcript)|interpro:IPR036855|ensemblmetazoa:FBtr0331173(transcript)|interpro:IPR041523|rcsb pdb:5LSW|ensemblmetazoa:FBtr0333265(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|mint:MINT-7711490(identity) go:"GO:0010494"(cytoplasmic stress granule) - - comment:homomint|comment:mint|figure legend:sf2c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2010/02/22 2014/10/16 rogid:d2ecwJo5sjSY6a/By3GM3B5A6PE9606 rogid:WgcoFShGg/ZtRJh/HWwHG/irjy47227 intact-crc:B80D5E50BD01719D|rigid:SGU7WSGmZTmhDCrn44Wb08RRRSs false - green fluorescent protein tag:?-?(MINT-7711491) - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0396"(predetermined participant)