#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8BYJ6 uniprotkb:P62259 intact:EBI-7920707|uniprotkb:Q3TAQ5|uniprotkb:Q8BMH6|intact:MINT-4113377|uniprotkb:Q66JU2|uniprotkb:Q6P2M2|uniprotkb:Q5DU23|uniprotkb:Q3T9E8|uniprotkb:Q8BXM2|uniprotkb:Q149C1|uniprotkb:Q149C0 intact:EBI-356480|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q63631|ensembl:ENSMUSP00000070993 psi-mi:tbcd4_mouse(display_long)|uniprotkb:Tbc1d4(gene name)|psi-mi:Tbc1d4(display_short)|uniprotkb:Kiaa0603(gene name synonym)|uniprotkb:Akt substrate of 160 kDa(gene name synonym)|uniprotkb:As160(gene name synonym) psi-mi:1433e_mouse(display_long)|uniprotkb:Ywhae(gene name)|psi-mi:Ywhae(display_short) psi-mi:"MI:0019"(coimmunoprecipitation) Liang et al. (2010) pubmed:20410134|mint:MINT-8009886|doi:10.1091/mbc.E10-01-0042 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7920744|mint:MINT-8009893 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011243304.1|refseq:NP_001074747.2|interpro:IPR021785|refseq:XP_006518822.1|mint:Q8BYJ6|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031339"(negative regulation of vesicle fusion)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035969|mint:MINT-8009897(identity)|uniprotkb:Q8BYJ6(original identifier) ensembl:ENSMUSG00000020849(gene)|ensembl:ENSMUST00000067664(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001764"(neuron migration)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0006605"(protein targeting)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|refseq:NP_033562.3|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62259|reactome:R-MMU-111447|reactome:R-MMU-2028269|reactome:R-MMU-205025|reactome:R-MMU-2565942|reactome:R-MMU-3371453|reactome:R-MMU-3371511|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-8854518|reactome:R-MMU-8876198|mint:MINT-8009894(identity)|uniprotkb:P62259(original identifier) - function:"May act as a GTPase-activating protein for Rab family protein(s)"|comment:mint - comment:homomint|comment:domino|comment:mint taxid:-3(unknown)|taxid:-3(Unknown) - 2010/09/21 2014/10/16 rogid:TK4mm644hBp495pEqT/dwTetRQo10090 rogid:mnuAjdnQZbMFojll2PnV3xFklXQ10090 intact-crc:CDDB644EA9D68003|rigid:Z7rkczX+VpRfusBivDd6vWNNhNw false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8BYJ6 uniprotkb:Q9CQV8 intact:EBI-7920707|uniprotkb:Q3TAQ5|uniprotkb:Q8BMH6|intact:MINT-4113377|uniprotkb:Q66JU2|uniprotkb:Q6P2M2|uniprotkb:Q5DU23|uniprotkb:Q3T9E8|uniprotkb:Q8BXM2|uniprotkb:Q149C1|uniprotkb:Q149C0 intact:EBI-771608|uniprotkb:O70455|uniprotkb:Q3TY33|uniprotkb:Q3UAN6|ensembl:ENSMUSP00000018470 psi-mi:tbcd4_mouse(display_long)|uniprotkb:Tbc1d4(gene name)|psi-mi:Tbc1d4(display_short)|uniprotkb:Kiaa0603(gene name synonym)|uniprotkb:Akt substrate of 160 kDa(gene name synonym)|uniprotkb:As160(gene name synonym) psi-mi:1433b_mouse(display_long)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:Ywhab(gene name)|psi-mi:Ywhab(display_short) psi-mi:"MI:0019"(coimmunoprecipitation) Liang et al. (2010) pubmed:20410134|mint:MINT-8009886|doi:10.1091/mbc.E10-01-0042 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7920757|mint:MINT-8009900 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011243304.1|refseq:NP_001074747.2|interpro:IPR021785|refseq:XP_006518822.1|mint:Q8BYJ6|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031339"(negative regulation of vesicle fusion)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035969|mint:MINT-8009904(identity)|uniprotkb:Q8BYJ6(original identifier) refseq:NP_061223.2|refseq:XP_006499972.1|reactome:R-MMU-111447|reactome:R-MMU-165159|reactome:R-MMU-166208|reactome:R-MMU-170968|reactome:R-MMU-2028269|reactome:R-MMU-392517|reactome:R-MMU-450385|reactome:R-MMU-450513|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5675221|reactome:R-MMU-75035|reactome:R-MMU-9614399|ensembl:ENSMUSG00000018326(gene)|ensembl:ENSMUST00000018470(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006605"(protein targeting)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|rcsb pdb:4GNT|rcsb pdb:5F74|rcsb pdb:5WFU|rcsb pdb:5WFX|mint:MINT-8009901(identity)|uniprotkb:Q9CQV8(original identifier) - function:"May act as a GTPase-activating protein for Rab family protein(s)"|comment:mint - comment:homomint|comment:domino|comment:mint taxid:-3(unknown)|taxid:-3(Unknown) - 2010/09/21 2014/10/16 rogid:TK4mm644hBp495pEqT/dwTetRQo10090 rogid:g94luGOxfq+Jbi0ztZ7gbAkp+2A10090 intact-crc:6C24D37267C71186|rigid:m4W9yBJTsdFhdcB1I+TH5wyKCRU false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8BYJ6 uniprotkb:P62259 intact:EBI-7920707|uniprotkb:Q3TAQ5|uniprotkb:Q8BMH6|intact:MINT-4113377|uniprotkb:Q66JU2|uniprotkb:Q6P2M2|uniprotkb:Q5DU23|uniprotkb:Q3T9E8|uniprotkb:Q8BXM2|uniprotkb:Q149C1|uniprotkb:Q149C0 intact:EBI-356480|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q63631|ensembl:ENSMUSP00000070993 psi-mi:tbcd4_mouse(display_long)|uniprotkb:Tbc1d4(gene name)|psi-mi:Tbc1d4(display_short)|uniprotkb:Kiaa0603(gene name synonym)|uniprotkb:Akt substrate of 160 kDa(gene name synonym)|uniprotkb:As160(gene name synonym) psi-mi:1433e_mouse(display_long)|uniprotkb:Ywhae(gene name)|psi-mi:Ywhae(display_short) psi-mi:"MI:0019"(coimmunoprecipitation) Liang et al. (2010) pubmed:20410134|mint:MINT-8009886|doi:10.1091/mbc.E10-01-0042 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7920787|mint:MINT-8009914 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011243304.1|refseq:NP_001074747.2|interpro:IPR021785|refseq:XP_006518822.1|mint:Q8BYJ6|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031339"(negative regulation of vesicle fusion)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035969|mint:MINT-8009918(identity)|uniprotkb:Q8BYJ6(original identifier) ensembl:ENSMUSG00000020849(gene)|ensembl:ENSMUST00000067664(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001764"(neuron migration)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0006605"(protein targeting)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|refseq:NP_033562.3|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62259|reactome:R-MMU-111447|reactome:R-MMU-2028269|reactome:R-MMU-205025|reactome:R-MMU-2565942|reactome:R-MMU-3371453|reactome:R-MMU-3371511|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-8854518|reactome:R-MMU-8876198|mint:MINT-8009915(identity)|uniprotkb:P62259(original identifier) - function:"May act as a GTPase-activating protein for Rab family protein(s)"|comment:mint - comment:homomint|comment:domino|comment:mint taxid:-3(unknown)|taxid:-3(Unknown) - 2010/09/21 2014/10/16 rogid:TK4mm644hBp495pEqT/dwTetRQo10090 rogid:mnuAjdnQZbMFojll2PnV3xFklXQ10090 intact-crc:6DF4B04B37591D88|rigid:Z7rkczX+VpRfusBivDd6vWNNhNw false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)