#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9HB90	uniprotkb:Q6IAA8	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Sancak et al. (2010)	imex:IM-14294|pubmed:20381137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2650077|imex:IM-14294-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2J|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/04/20	2014/10/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:D282BC819A653F81|rigid:XSH/qzPG2VFQhsh66g56SZ56eX0	false	-	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q5VZM2	uniprotkb:Q9UHA4	intact:EBI-993049|uniprotkb:Q15348|uniprotkb:Q8N3T0|uniprotkb:A8K042|ensembl:ENSP00000262850	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:rragb_human(display_long)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sancak et al. (2010)	imex:IM-14294|pubmed:20381137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2643695|imex:IM-14294-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000083750(gene)|ensembl:ENST00000262850(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|interpro:IPR039397|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|interpro:IPR027417|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032561"(guanyl ribonucleotide binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|refseq:NP_006055.3|refseq:NP_057740.2|dip:DIP-37518N	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/04/20	2014/10/16	rogid:YhR9rFpvxfj0eI6wvvlvLn3IRbs9606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	intact-crc:CDF9FADA7C3DFBA0|rigid:jAO/6EdMekH90RrMQTSztqMvMSo	false	flag tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5VZM2	uniprotkb:Q9Y2Q5	intact:EBI-993049|uniprotkb:Q15348|uniprotkb:Q8N3T0|uniprotkb:A8K042|ensembl:ENSP00000262850	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	psi-mi:rragb_human(display_long)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sancak et al. (2010)	imex:IM-14294|pubmed:20381137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2643695|imex:IM-14294-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000083750(gene)|ensembl:ENST00000262850(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|interpro:IPR039397|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|interpro:IPR027417|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032561"(guanyl ribonucleotide binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|refseq:NP_006055.3|refseq:NP_057740.2|dip:DIP-37518N	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/04/20	2014/10/16	rogid:YhR9rFpvxfj0eI6wvvlvLn3IRbs9606	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	intact-crc:CDF9FADA7C3DFBA0|rigid:jAO/6EdMekH90RrMQTSztqMvMSo	false	flag tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5VZM2	uniprotkb:Q6IAA8	intact:EBI-993049|uniprotkb:Q15348|uniprotkb:Q8N3T0|uniprotkb:A8K042|ensembl:ENSP00000262850	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:rragb_human(display_long)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sancak et al. (2010)	imex:IM-14294|pubmed:20381137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2643695|imex:IM-14294-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000083750(gene)|ensembl:ENST00000262850(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|interpro:IPR039397|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|interpro:IPR027417|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032561"(guanyl ribonucleotide binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|refseq:NP_006055.3|refseq:NP_057740.2|dip:DIP-37518N	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/04/20	2014/10/16	rogid:YhR9rFpvxfj0eI6wvvlvLn3IRbs9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:CDF9FADA7C3DFBA0|rigid:jAO/6EdMekH90RrMQTSztqMvMSo	false	flag tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9NQL2	uniprotkb:Q9Y2Q5	intact:EBI-992949|uniprotkb:Q7L8F9|uniprotkb:Q9NPG0|uniprotkb:A8K184|ensembl:ENSP00000358423	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	psi-mi:rragd_human(display_long)|uniprotkb:RRAGD(gene name)|psi-mi:RRAGD(display_short)	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sancak et al. (2010)	imex:IM-14294|pubmed:20381137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2643735|imex:IM-14294-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|interpro:IPR027417|interpro:IPR039400|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|rcsb pdb:2Q3F|reactome:R-HSA-1632852|go:"GO:0019003"(GDP binding)|go:"GO:0032008"(positive regulation of TOR signaling)|reactome:R-HSA-165159|reactome:R-HSA-166208|go:"GO:0034613"(cellular protein localization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|reactome:R-HSA-380972|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|ensembl:ENSG00000025039(gene)|ensembl:ENST00000369415(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|refseq:NP_067067.1	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/04/20	2014/10/16	rogid:o/eKSagtR5k8XpaXBdpq9S3NiUQ9606	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	intact-crc:47EA943099CDA8DB|rigid:4iwWCig8uSXSVPKzGnylE+CqoD4	false	flag tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9NQL2	uniprotkb:Q9UHA4	intact:EBI-992949|uniprotkb:Q7L8F9|uniprotkb:Q9NPG0|uniprotkb:A8K184|ensembl:ENSP00000358423	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:rragd_human(display_long)|uniprotkb:RRAGD(gene name)|psi-mi:RRAGD(display_short)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sancak et al. (2010)	imex:IM-14294|pubmed:20381137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2643735|imex:IM-14294-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|interpro:IPR027417|interpro:IPR039400|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|rcsb pdb:2Q3F|reactome:R-HSA-1632852|go:"GO:0019003"(GDP binding)|go:"GO:0032008"(positive regulation of TOR signaling)|reactome:R-HSA-165159|reactome:R-HSA-166208|go:"GO:0034613"(cellular protein localization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|reactome:R-HSA-380972|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|ensembl:ENSG00000025039(gene)|ensembl:ENST00000369415(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|refseq:NP_067067.1	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/04/20	2014/10/16	rogid:o/eKSagtR5k8XpaXBdpq9S3NiUQ9606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	intact-crc:47EA943099CDA8DB|rigid:4iwWCig8uSXSVPKzGnylE+CqoD4	false	flag tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9NQL2	uniprotkb:Q6IAA8	intact:EBI-992949|uniprotkb:Q7L8F9|uniprotkb:Q9NPG0|uniprotkb:A8K184|ensembl:ENSP00000358423	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:rragd_human(display_long)|uniprotkb:RRAGD(gene name)|psi-mi:RRAGD(display_short)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sancak et al. (2010)	imex:IM-14294|pubmed:20381137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2643735|imex:IM-14294-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|interpro:IPR027417|interpro:IPR039400|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|rcsb pdb:2Q3F|reactome:R-HSA-1632852|go:"GO:0019003"(GDP binding)|go:"GO:0032008"(positive regulation of TOR signaling)|reactome:R-HSA-165159|reactome:R-HSA-166208|go:"GO:0034613"(cellular protein localization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|reactome:R-HSA-380972|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|ensembl:ENSG00000025039(gene)|ensembl:ENST00000369415(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|refseq:NP_067067.1	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/04/20	2014/10/16	rogid:o/eKSagtR5k8XpaXBdpq9S3NiUQ9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:47EA943099CDA8DB|rigid:4iwWCig8uSXSVPKzGnylE+CqoD4	false	flag tag:?-?	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q9Y2Q5	uniprotkb:Q5VZM2	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	intact:EBI-993049|uniprotkb:Q15348|uniprotkb:Q8N3T0|uniprotkb:A8K042|ensembl:ENSP00000262850	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:rragb_human(display_long)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sancak et al. (2010)	imex:IM-14294|pubmed:20381137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2643871|imex:IM-14294-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	ensembl:ENSG00000083750(gene)|ensembl:ENST00000262850(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|interpro:IPR039397|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|interpro:IPR027417|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032561"(guanyl ribonucleotide binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|refseq:NP_006055.3|refseq:NP_057740.2|dip:DIP-37518N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/04/20	2014/10/16	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rogid:YhR9rFpvxfj0eI6wvvlvLn3IRbs9606	intact-crc:CFA0107C4CCD6B2B|rigid:9Ugofv0yiRWx2r1Yb2ZbeBDJ/Pc	false	flag tag:?-?	glutathione s tranferase tag:?-?|ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y2Q5	uniprotkb:Q9NQL2	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	intact:EBI-992949|uniprotkb:Q7L8F9|uniprotkb:Q9NPG0|uniprotkb:A8K184|ensembl:ENSP00000358423	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:rragd_human(display_long)|uniprotkb:RRAGD(gene name)|psi-mi:RRAGD(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sancak et al. (2010)	imex:IM-14294|pubmed:20381137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2643871|imex:IM-14294-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|interpro:IPR027417|interpro:IPR039400|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|rcsb pdb:2Q3F|reactome:R-HSA-1632852|go:"GO:0019003"(GDP binding)|go:"GO:0032008"(positive regulation of TOR signaling)|reactome:R-HSA-165159|reactome:R-HSA-166208|go:"GO:0034613"(cellular protein localization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|reactome:R-HSA-380972|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|ensembl:ENSG00000025039(gene)|ensembl:ENST00000369415(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|refseq:NP_067067.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/04/20	2014/10/16	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rogid:o/eKSagtR5k8XpaXBdpq9S3NiUQ9606	intact-crc:CFA0107C4CCD6B2B|rigid:9Ugofv0yiRWx2r1Yb2ZbeBDJ/Pc	false	flag tag:?-?	glutathione s tranferase tag:?-?|ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y2Q5	uniprotkb:Q9UHA4	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sancak et al. (2010)	imex:IM-14294|pubmed:20381137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2643871|imex:IM-14294-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/04/20	2014/10/16	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	intact-crc:CFA0107C4CCD6B2B|rigid:9Ugofv0yiRWx2r1Yb2ZbeBDJ/Pc	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y2Q5	uniprotkb:Q6IAA8	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sancak et al. (2010)	imex:IM-14294|pubmed:20381137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2643871|imex:IM-14294-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/04/20	2014/10/16	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:CFA0107C4CCD6B2B|rigid:9Ugofv0yiRWx2r1Yb2ZbeBDJ/Pc	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y2Q5	uniprotkb:Q5VZM2	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	intact:EBI-993049|uniprotkb:Q15348|uniprotkb:Q8N3T0|uniprotkb:A8K042|ensembl:ENSP00000262850	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:rragb_human(display_long)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sancak et al. (2010)	imex:IM-14294|pubmed:20381137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2650000|imex:IM-14294-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	ensembl:ENSG00000083750(gene)|ensembl:ENST00000262850(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|interpro:IPR039397|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|interpro:IPR027417|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032561"(guanyl ribonucleotide binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|refseq:NP_006055.3|refseq:NP_057740.2|dip:DIP-37518N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/04/20	2014/10/16	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rogid:YhR9rFpvxfj0eI6wvvlvLn3IRbs9606	intact-crc:8967BC7A096BF048|rigid:Ualwa/fJxeLTFxG5uAyiQTcc9lk	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y2Q5	uniprotkb:Q9NQL2	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	intact:EBI-992949|uniprotkb:Q7L8F9|uniprotkb:Q9NPG0|uniprotkb:A8K184|ensembl:ENSP00000358423	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:rragd_human(display_long)|uniprotkb:RRAGD(gene name)|psi-mi:RRAGD(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sancak et al. (2010)	imex:IM-14294|pubmed:20381137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2650000|imex:IM-14294-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|interpro:IPR027417|interpro:IPR039400|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|rcsb pdb:2Q3F|reactome:R-HSA-1632852|go:"GO:0019003"(GDP binding)|go:"GO:0032008"(positive regulation of TOR signaling)|reactome:R-HSA-165159|reactome:R-HSA-166208|go:"GO:0034613"(cellular protein localization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|reactome:R-HSA-380972|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|ensembl:ENSG00000025039(gene)|ensembl:ENST00000369415(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|refseq:NP_067067.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/04/20	2014/10/16	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rogid:o/eKSagtR5k8XpaXBdpq9S3NiUQ9606	intact-crc:8967BC7A096BF048|rigid:Ualwa/fJxeLTFxG5uAyiQTcc9lk	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y2Q5	uniprotkb:Q7L523	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sancak et al. (2010)	imex:IM-14294|pubmed:20381137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2650000|imex:IM-14294-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/04/20	2014/10/16	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	intact-crc:8967BC7A096BF048|rigid:Ualwa/fJxeLTFxG5uAyiQTcc9lk	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y2Q5	uniprotkb:Q6IAA8	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sancak et al. (2010)	imex:IM-14294|pubmed:20381137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2650000|imex:IM-14294-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/04/20	2014/10/16	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:8967BC7A096BF048|rigid:Ualwa/fJxeLTFxG5uAyiQTcc9lk	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y2Q5	uniprotkb:Q9UHA4	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sancak et al. (2010)	imex:IM-14294|pubmed:20381137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2650000|imex:IM-14294-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/04/20	2014/10/16	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	intact-crc:8967BC7A096BF048|rigid:Ualwa/fJxeLTFxG5uAyiQTcc9lk	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5VZM2	uniprotkb:Q9NQL2	intact:EBI-993049|uniprotkb:Q15348|uniprotkb:Q8N3T0|uniprotkb:A8K042|ensembl:ENSP00000262850	intact:EBI-992949|uniprotkb:Q7L8F9|uniprotkb:Q9NPG0|uniprotkb:A8K184|ensembl:ENSP00000358423	psi-mi:rragb_human(display_long)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:rragd_human(display_long)|uniprotkb:RRAGD(gene name)|psi-mi:RRAGD(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sancak et al. (2010)	imex:IM-14294|pubmed:20381137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2650026|imex:IM-14294-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000083750(gene)|ensembl:ENST00000262850(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|interpro:IPR039397|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|interpro:IPR027417|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032561"(guanyl ribonucleotide binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|refseq:NP_006055.3|refseq:NP_057740.2|dip:DIP-37518N	go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|interpro:IPR027417|interpro:IPR039400|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|rcsb pdb:2Q3F|reactome:R-HSA-1632852|go:"GO:0019003"(GDP binding)|go:"GO:0032008"(positive regulation of TOR signaling)|reactome:R-HSA-165159|reactome:R-HSA-166208|go:"GO:0034613"(cellular protein localization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|reactome:R-HSA-380972|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|ensembl:ENSG00000025039(gene)|ensembl:ENST00000369415(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|refseq:NP_067067.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/04/20	2014/10/16	rogid:YhR9rFpvxfj0eI6wvvlvLn3IRbs9606	rogid:o/eKSagtR5k8XpaXBdpq9S3NiUQ9606	intact-crc:360C092DBAC5A000|rigid:9Ugofv0yiRWx2r1Yb2ZbeBDJ/Pc	false	glutathione s tranferase tag:?-?|ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5VZM2	uniprotkb:Q9Y2Q5	intact:EBI-993049|uniprotkb:Q15348|uniprotkb:Q8N3T0|uniprotkb:A8K042|ensembl:ENSP00000262850	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	psi-mi:rragb_human(display_long)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sancak et al. (2010)	imex:IM-14294|pubmed:20381137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2650026|imex:IM-14294-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000083750(gene)|ensembl:ENST00000262850(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|interpro:IPR039397|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|interpro:IPR027417|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032561"(guanyl ribonucleotide binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|refseq:NP_006055.3|refseq:NP_057740.2|dip:DIP-37518N	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/04/20	2014/10/16	rogid:YhR9rFpvxfj0eI6wvvlvLn3IRbs9606	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	intact-crc:360C092DBAC5A000|rigid:9Ugofv0yiRWx2r1Yb2ZbeBDJ/Pc	false	glutathione s tranferase tag:?-?|ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5VZM2	uniprotkb:Q6IAA8	intact:EBI-993049|uniprotkb:Q15348|uniprotkb:Q8N3T0|uniprotkb:A8K042|ensembl:ENSP00000262850	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:rragb_human(display_long)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sancak et al. (2010)	imex:IM-14294|pubmed:20381137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2650026|imex:IM-14294-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000083750(gene)|ensembl:ENST00000262850(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|interpro:IPR039397|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|interpro:IPR027417|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032561"(guanyl ribonucleotide binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|refseq:NP_006055.3|refseq:NP_057740.2|dip:DIP-37518N	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/04/20	2014/10/16	rogid:YhR9rFpvxfj0eI6wvvlvLn3IRbs9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:360C092DBAC5A000|rigid:9Ugofv0yiRWx2r1Yb2ZbeBDJ/Pc	false	glutathione s tranferase tag:?-?|ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5VZM2	uniprotkb:Q9UHA4	intact:EBI-993049|uniprotkb:Q15348|uniprotkb:Q8N3T0|uniprotkb:A8K042|ensembl:ENSP00000262850	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:rragb_human(display_long)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sancak et al. (2010)	imex:IM-14294|pubmed:20381137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2650026|imex:IM-14294-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000083750(gene)|ensembl:ENST00000262850(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|interpro:IPR039397|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|interpro:IPR027417|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032561"(guanyl ribonucleotide binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|refseq:NP_006055.3|refseq:NP_057740.2|dip:DIP-37518N	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/04/20	2014/10/16	rogid:YhR9rFpvxfj0eI6wvvlvLn3IRbs9606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	intact-crc:360C092DBAC5A000|rigid:9Ugofv0yiRWx2r1Yb2ZbeBDJ/Pc	false	glutathione s tranferase tag:?-?|ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5VZM2	uniprotkb:Q9UHA4	intact:EBI-993049|uniprotkb:Q15348|uniprotkb:Q8N3T0|uniprotkb:A8K042|ensembl:ENSP00000262850	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:rragb_human(display_long)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sancak et al. (2010)	imex:IM-14294|pubmed:20381137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2650063|imex:IM-14294-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000083750(gene)|ensembl:ENST00000262850(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|interpro:IPR039397|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|interpro:IPR027417|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032561"(guanyl ribonucleotide binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|refseq:NP_006055.3|refseq:NP_057740.2|dip:DIP-37518N	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2I|comment:Endogenous Ragulator coimmunoprecipitates with FLAG-RagB independently of amino acid availability and GTP-loading of RagB.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/04/20	2014/10/16	rogid:YhR9rFpvxfj0eI6wvvlvLn3IRbs9606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	intact-crc:11029E2DC2809E15|rigid:jAO/6EdMekH90RrMQTSztqMvMSo	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5VZM2	uniprotkb:Q9Y2Q5	intact:EBI-993049|uniprotkb:Q15348|uniprotkb:Q8N3T0|uniprotkb:A8K042|ensembl:ENSP00000262850	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	psi-mi:rragb_human(display_long)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sancak et al. (2010)	imex:IM-14294|pubmed:20381137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2650063|imex:IM-14294-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000083750(gene)|ensembl:ENST00000262850(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|interpro:IPR039397|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|interpro:IPR027417|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032561"(guanyl ribonucleotide binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|refseq:NP_006055.3|refseq:NP_057740.2|dip:DIP-37518N	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2I|comment:Endogenous Ragulator coimmunoprecipitates with FLAG-RagB independently of amino acid availability and GTP-loading of RagB.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/04/20	2014/10/16	rogid:YhR9rFpvxfj0eI6wvvlvLn3IRbs9606	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	intact-crc:11029E2DC2809E15|rigid:jAO/6EdMekH90RrMQTSztqMvMSo	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5VZM2	uniprotkb:Q6IAA8	intact:EBI-993049|uniprotkb:Q15348|uniprotkb:Q8N3T0|uniprotkb:A8K042|ensembl:ENSP00000262850	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:rragb_human(display_long)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sancak et al. (2010)	imex:IM-14294|pubmed:20381137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2650063|imex:IM-14294-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000083750(gene)|ensembl:ENST00000262850(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|interpro:IPR039397|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|interpro:IPR027417|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032561"(guanyl ribonucleotide binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|refseq:NP_006055.3|refseq:NP_057740.2|dip:DIP-37518N	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2I|comment:Endogenous Ragulator coimmunoprecipitates with FLAG-RagB independently of amino acid availability and GTP-loading of RagB.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/04/20	2014/10/16	rogid:YhR9rFpvxfj0eI6wvvlvLn3IRbs9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:11029E2DC2809E15|rigid:jAO/6EdMekH90RrMQTSztqMvMSo	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HB90	uniprotkb:Q5VZM2	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-993049|uniprotkb:Q15348|uniprotkb:Q8N3T0|uniprotkb:A8K042|ensembl:ENSP00000262850	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:rragb_human(display_long)|uniprotkb:RRAGB(gene name)|psi-mi:RRAGB(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sancak et al. (2010)	imex:IM-14294|pubmed:20381137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2643682|imex:IM-14294-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	ensembl:ENSG00000083750(gene)|ensembl:ENST00000262850(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|interpro:IPR039397|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|interpro:IPR027417|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032561"(guanyl ribonucleotide binding)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR006762(Gtr1/RagA G protein)|refseq:NP_006055.3|refseq:NP_057740.2|dip:DIP-37518N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/04/20	2014/10/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:YhR9rFpvxfj0eI6wvvlvLn3IRbs9606	intact-crc:40EAC2BEDCDCE5C1|rigid:3eAoAK9M/CiKNUDSqAYbSkUUz70	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HB90	uniprotkb:Q7L523	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sancak et al. (2010)	imex:IM-14294|pubmed:20381137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2643682|imex:IM-14294-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/04/20	2014/10/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	intact-crc:40EAC2BEDCDCE5C1|rigid:3eAoAK9M/CiKNUDSqAYbSkUUz70	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HB90	uniprotkb:Q9Y2Q5	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-2643704|uniprotkb:Q5VY99|uniprotkb:Q5VY97|ensembl:ENSP00000357288|uniprotkb:Q5VY98	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:ltor2_human(display_long)|uniprotkb:LAMTOR2(gene name)|psi-mi:LAMTOR2(display_short)|uniprotkb:MAPBPIP(gene name synonym)|uniprotkb:Late endosomal/lysosomal Mp1-interacting protein(gene name synonym)|uniprotkb:Roadblock domain-containing protein 3(gene name synonym)|uniprotkb:Endosomal adaptor protein p14(gene name synonym)|uniprotkb:HSPC003(orf name)|uniprotkb:ROBLD3(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2(gene name synonym)|uniprotkb:Mitogen-activated protein-binding protein-interacting protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sancak et al. (2010)	imex:IM-14294|pubmed:20381137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2650056|imex:IM-14294-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_054736.1|ensembl:ENSG00000116586(gene)|ensembl:ENST00000368305(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010761"(fibroblast migration)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0150116"(regulation of cell-substrate junction organization)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR037587|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|refseq:NP_001138736.1|dip:DIP-57000N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2F|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/04/20	2014/10/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:3durREyQgqI8N4q7RMVh9drah3s9606	intact-crc:72E8BCD80ABFD7C5|rigid:4kyS2icaq9vW5hm2aHw44Vik2k0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HB90	uniprotkb:Q7L523	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sancak et al. (2010)	imex:IM-14294|pubmed:20381137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2650056|imex:IM-14294-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2F|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/04/20	2014/10/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	intact-crc:72E8BCD80ABFD7C5|rigid:4kyS2icaq9vW5hm2aHw44Vik2k0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HB90	uniprotkb:Q9UHA4	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	intact:EBI-1038192|uniprotkb:Q9H364|uniprotkb:J3KMX4|uniprotkb:B2R4A1|ensembl:ENSP00000424183	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:ltor3_human(display_long)|uniprotkb:MAP2K1IP1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase 1-interacting protein 1(gene name synonym)|uniprotkb:LAMTOR3(gene name)|psi-mi:LAMTOR3(display_short)|uniprotkb:PRO2783(orf name)|uniprotkb:MEK-binding partner 1(gene name synonym)|uniprotkb:MAPKSP1(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase scaffold protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sancak et al. (2010)	imex:IM-14294|pubmed:20381137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2650056|imex:IM-14294-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	refseq:NP_068805.1|ensembl:ENSG00000109270(gene)|ensembl:ENST00000499666(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010008"(endosome membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR015019(Mitogen-activated protein kinase kinase 1 interacting)|rcsb pdb:1SKO|rcsb pdb:2ZL1|rcsb pdb:3CPT|rcsb pdb:5X6U|rcsb pdb:5X6V|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9639288|rcsb pdb:6U62|refseq:NP_001230665.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2F|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/04/20	2014/10/16	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rogid:0QvFsMOMU2EZyUVVVUqBij+gsKw9606	intact-crc:72E8BCD80ABFD7C5|rigid:4kyS2icaq9vW5hm2aHw44Vik2k0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)