#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P39900	uniprotkb:P15502-2	intact:EBI-7881912|uniprotkb:B2R9X8|uniprotkb:B7ZLF6|intact:MINT-7709562|uniprotkb:Q2M1L9|ensembl:ENSP00000458585	intact:EBI-7882008|intact:MINT-7709520|ensembl:ENSP00000252034	psi-mi:mmp12_human(display_long)|uniprotkb:MMP12(gene name)|psi-mi:MMP12(display_short)|uniprotkb:HME(gene name synonym)|uniprotkb:Matrix metalloproteinase-12(gene name synonym)|uniprotkb:Macrophage elastase(gene name synonym)	psi-mi:p15502-2(display_long)|uniprotkb:ELN(gene name)|psi-mi:ELN(display_short)|uniprotkb:Tropoelastin(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Heinz et al. (2010)	pubmed:20345904|imex:IM-15692|mint:MINT-7709230|mint:fj-10-0016|doi:10.1111/j.1742-4658.2010.07616	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7881906|mint:MINT-7709289|imex:IM-15692-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002417.2|rcsb pdb:2OXZ|rcsb pdb:2POJ|rcsb pdb:2W0D|rcsb pdb:2WO8|rcsb pdb:2WO9|rcsb pdb:2WOA|rcsb pdb:1UTT|rcsb pdb:1UTZ|rcsb pdb:1Y93|rcsb pdb:1YCM|rcsb pdb:2Z2D|rcsb pdb:3BA0|rcsb pdb:3EHX|rcsb pdb:3EHY|rcsb pdb:3F15|rcsb pdb:1Z3J|rcsb pdb:3F16|rcsb pdb:3F17|rcsb pdb:3F18|rcsb pdb:3F19|rcsb pdb:3F1A|rcsb pdb:2HU6|rcsb pdb:3LIK|rcsb pdb:3LIL|rcsb pdb:3LIR|rcsb pdb:3LJG|rcsb pdb:3LK8|rcsb pdb:3LKA|rcsb pdb:3N2U|rcsb pdb:3N2V|rcsb pdb:3NX7|rcsb pdb:2JXY|rcsb pdb:3RTS|rcsb pdb:3RTT|rcsb pdb:3TS4|rcsb pdb:3TSK|rcsb pdb:3UVC|rcsb pdb:4EFS|rcsb pdb:2K2G|rcsb pdb:4GQL|rcsb pdb:4GR0|rcsb pdb:4GR3|rcsb pdb:4GR8|rcsb pdb:4GUY|rcsb pdb:4H30|rcsb pdb:2K9C|rcsb pdb:4H49|rcsb pdb:4H76|rcsb pdb:4H84|rcsb pdb:4I03|rcsb pdb:4IJO|rcsb pdb:2KRJ|rcsb pdb:5CXA|rcsb pdb:5CZM|rcsb pdb:5D2B|rcsb pdb:5D3C|rcsb pdb:5I0L|rcsb pdb:5I2Z|rcsb pdb:5I3M|rcsb pdb:5I43|rcsb pdb:5I4O|rcsb pdb:5L79|rcsb pdb:5L7F|rcsb pdb:2MLR|rcsb pdb:2MLS|rcsb pdb:2N8R|rcsb pdb:2OXU|rcsb pdb:2OXW|rcsb pdb:5LAB|rcsb pdb:5N5J|rcsb pdb:5N5K|rcsb pdb:6EKN|rcsb pdb:6ELA|rcsb pdb:6ENM|rcsb pdb:6EOX|rcsb pdb:6RD0|rcsb pdb:6RLY|reactome:R-HSA-1442490|reactome:R-HSA-1474228|ensembl:ENSG00000262406(gene)|ensembl:ENST00000571244(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006508"(proteolysis)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048286"(lung alveolus development)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0060054"(positive regulation of epithelial cell proliferation involved in wound healing)|go:"GO:0060309"(elastin catabolic process)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0060435"(bronchiole development)|go:"GO:0098586"(cellular response to virus)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904905"(negative regulation of endothelial cell-matrix adhesion via fibronectin)|interpro:IPR000585(Hemopexin)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR018486|interpro:IPR018487|interpro:IPR021158|interpro:IPR021190|interpro:IPR024079|interpro:IPR033739|interpro:IPR036365|interpro:IPR036375|rcsb pdb:1JIZ|rcsb pdb:1JK3|rcsb pdb:1OS2|rcsb pdb:1OS9|rcsb pdb:1RMZ|rcsb pdb:1ROS|mint:MINT-7709620(identity)	intact:EBI-1222108(isoform-parent)|ensembl:ENSG00000049540(gene)|ensembl:ENST00000252034(transcript)|mint:MINT-7709291(identity)	-	comment:mint	comment:mint	comment:homomint|comment:mint|figure legend:t1 t2 t3 t4 f2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/02/12	2014/10/16	rogid:gnXtCJ/ZitEoWEiC0OLVAjcEfDU9606	rogid:o23L3ivLVgzAoimUtThecDN/QS49606	intact-crc:36FEA46A130DF202|rigid:lYCuuXRulL6e7TYEiBiNS72mDL0	false	binding-associated region:84-255(MINT-7709621)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15502-2	uniprotkb:P14780	intact:EBI-7882008|intact:MINT-7709520|ensembl:ENSP00000252034	intact:EBI-1382326|uniprotkb:Q3LR70|uniprotkb:Q8N725|uniprotkb:Q9H4Z1|uniprotkb:B2R7V9|uniprotkb:Q9UCJ9|uniprotkb:Q9UCL1|uniprotkb:Q9UDK2|ensembl:ENSP00000361405	psi-mi:p15502-2(display_long)|uniprotkb:ELN(gene name)|psi-mi:ELN(display_short)|uniprotkb:Tropoelastin(gene name synonym)	psi-mi:mmp9_human(display_long)|uniprotkb:MMP9(gene name)|psi-mi:MMP9(display_short)|uniprotkb:CLG4B(gene name synonym)|uniprotkb:92 kDa type IV collagenase(gene name synonym)|uniprotkb:92 kDa gelatinase(gene name synonym)|uniprotkb:Gelatinase B(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Heinz et al. (2010)	pubmed:20345904|imex:IM-15692|mint:MINT-7709230|mint:fj-10-0016|doi:10.1111/j.1742-4658.2010.07616	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7882083|mint:MINT-7709668|imex:IM-15692-3	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222108(isoform-parent)|ensembl:ENSG00000049540(gene)|ensembl:ENST00000252034(transcript)|mint:MINT-7709674(identity)	refseq:NP_004985.2|dip:DIP-29518N|ensembl:ENSG00000100985(gene)|ensembl:ENST00000372330(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006508"(proteolysis)|go:"GO:0007566"(embryo implantation)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000697"(negative regulation of epithelial cell differentiation involved in kidney development)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001258"(negative regulation of cation channel activity)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR000585(Hemopexin)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018486|interpro:IPR018487|interpro:IPR021158|interpro:IPR021190|interpro:IPR024079|interpro:IPR028688|interpro:IPR033739|go:"GO:1900122"(positive regulation of receptor binding)|interpro:IPR036365|interpro:IPR036375|interpro:IPR036943|mint:P14780|rcsb pdb:1GKC|rcsb pdb:1GKD|rcsb pdb:1ITV|rcsb pdb:1L6J|rcsb pdb:1LKG|rcsb pdb:2OVX|rcsb pdb:2OVZ|rcsb pdb:2OW0|rcsb pdb:2OW1|rcsb pdb:2OW2|rcsb pdb:4H1Q|rcsb pdb:4H2E|rcsb pdb:4H3X|rcsb pdb:4H82|rcsb pdb:4HMA|rcsb pdb:4JIJ|rcsb pdb:4JQG|rcsb pdb:4WZV|rcsb pdb:4XCT|rcsb pdb:5CUH|rcsb pdb:5I12|rcsb pdb:5TH6|rcsb pdb:5TH9|rcsb pdb:5UE3|rcsb pdb:5UE4|rcsb pdb:6ESM|reactome:R-HSA-1433557|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-2022090|reactome:R-HSA-3928665|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-9009391|mint:MINT-7709670(identity)	-	comment:mint	-	comment:homomint|comment:mint|figure legend:t1 t2 t3 t4 f2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/02/12	2014/10/16	rogid:o23L3ivLVgzAoimUtThecDN/QS49606	rogid:0PnzH1KPp4SKRWfRGotPA2eSHZk9606	intact-crc:3425ACB232F717DF|rigid:seWG03VOFdRNduJIjnUGoB/7haE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15502-2	uniprotkb:P09237	intact:EBI-7882008|intact:MINT-7709520|ensembl:ENSP00000252034	intact:EBI-6595344|ensembl:ENSP00000260227|uniprotkb:Q9BTK9	psi-mi:p15502-2(display_long)|uniprotkb:ELN(gene name)|psi-mi:ELN(display_short)|uniprotkb:Tropoelastin(gene name synonym)	psi-mi:mmp7_human(display_long)|uniprotkb:MMP7(gene name)|psi-mi:MMP7(display_short)|uniprotkb:MPSL1(gene name synonym)|uniprotkb:Matrin(gene name synonym)|uniprotkb:Matrix metalloproteinase-7(gene name synonym)|uniprotkb:PUMP1(gene name synonym)|uniprotkb:Pump-1 protease(gene name synonym)|uniprotkb:Uterine metalloproteinase(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Heinz et al. (2010)	pubmed:20345904|imex:IM-15692|mint:MINT-7709230|mint:fj-10-0016|doi:10.1111/j.1742-4658.2010.07616	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7882068|mint:MINT-7709630|imex:IM-15692-2	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1222108(isoform-parent)|ensembl:ENSG00000049540(gene)|ensembl:ENST00000252034(transcript)|mint:MINT-7709632(identity)	ensembl:ENSG00000137673(gene)|ensembl:ENST00000260227(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007568"(aging)|go:"GO:0008201"(heparin binding)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0044849"(estrous cycle)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR021158|interpro:IPR021190|interpro:IPR024079|interpro:IPR028707|interpro:IPR033739|interpro:IPR036365|rcsb pdb:1MMP|rcsb pdb:1MMQ|rcsb pdb:1MMR|rcsb pdb:2DDY|rcsb pdb:2MZE|rcsb pdb:2MZH|rcsb pdb:2MZI|rcsb pdb:2Y6C|rcsb pdb:2Y6D|rcsb pdb:5UE2|rcsb pdb:5UE5|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-2022090|reactome:R-HSA-9009391|refseq:NP_002414.1|mint:MINT-7709634(identity)	-	comment:mint	-	comment:homomint|comment:mint|figure legend:t1 t2 t3 t4 f2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/02/12	2014/10/16	rogid:o23L3ivLVgzAoimUtThecDN/QS49606	rogid:Y2dg8oVA+l4R+n6oL2pWyv4WOJs9606	intact-crc:C55502B145EE44E4|rigid:k+Qq9XY2Z7mWTwyFGYK6ia+Arg8	false	-	binding-associated region:78-250(MINT-7709635)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)